-- dump date 20120504_144728 -- class Genbank::misc_feature -- table misc_feature_note -- id note 441952000001 chromosomal replication initiation protein; Reviewed; Region: dnaA; PRK00149 441952000002 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 441952000003 Walker A motif; other site 441952000004 ATP binding site [chemical binding]; other site 441952000005 Walker B motif; other site 441952000006 arginine finger; other site 441952000007 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 441952000008 DnaA box-binding interface [nucleotide binding]; other site 441952000009 DNA polymerase III subunit beta; Validated; Region: PRK05643 441952000010 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 441952000011 putative DNA binding surface [nucleotide binding]; other site 441952000012 dimer interface [polypeptide binding]; other site 441952000013 beta-clamp/clamp loader binding surface; other site 441952000014 beta-clamp/translesion DNA polymerase binding surface; other site 441952000015 Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814 441952000016 Transmembrane amino acid transporter protein; Region: Aa_trans; cl15776 441952000017 Stress responsive A/B Barrel Domain; Region: Dabb; cl15807 441952000018 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 441952000019 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 441952000020 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 441952000021 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 441952000022 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 441952000023 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 441952000024 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 441952000025 ATP-grasp domain; Region: ATP-grasp_4; cl03087 441952000026 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 441952000027 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 441952000028 ATP-grasp domain; Region: ATP-grasp_4; cl03087 441952000029 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 441952000030 IMP binding site; other site 441952000031 dimer interface [polypeptide binding]; other site 441952000032 interdomain contacts; other site 441952000033 partial ornithine binding site; other site 441952000034 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 441952000035 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; cl03056 441952000036 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 441952000037 catalytic site [active] 441952000038 subunit interface [polypeptide binding]; other site 441952000039 Histidine phosphatase domain found in histidine acid phosphatases and phytases; contains a His residue which is phosphorylated during the reaction; Region: HP_HAP_like; cd07061 441952000040 catalytic core [active] 441952000041 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl15754 441952000042 dihydroorotase; Reviewed; Region: PRK09236 441952000043 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 441952000044 Dihydroorotase (DHOase), subgroup IIb; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This group contains the archeal members of the DHOase family; Region: DHOase_IIb; cd01318 441952000045 active site 441952000046 Domain of unknown function (DUF4325); Region: DUF4325; pfam14213 441952000047 Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566 441952000048 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 441952000049 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 441952000050 Protein of unknown function (DUF3568); Region: DUF3568; pfam12092 441952000051 Transcriptional regulator [Transcription]; Region: LysR; COG0583 441952000052 Helix-turn-helix domains; Region: HTH; cl00088 441952000053 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 441952000054 dimerization interface [polypeptide binding]; other site 441952000055 SOUL heme-binding protein; Region: SOUL; pfam04832 441952000056 Chorismate mutase type II; Region: CM_2; cl00693 441952000057 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase contains two...; Region: OMP_decarboxylase_like; cd04725 441952000058 active site 441952000059 dimer interface [polypeptide binding]; other site 441952000060 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl09108 441952000061 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl09108 441952000062 phosphate binding site [ion binding]; other site 441952000063 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563 441952000064 putative active site [active] 441952000065 dimerization interface [polypeptide binding]; other site 441952000066 putative tRNAtyr binding site [nucleotide binding]; other site 441952000067 Glycosyl hydrolases family 32 N-terminal domain; Region: Glyco_hydro_32N; pfam00251 441952000068 Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996 441952000069 substrate binding [chemical binding]; other site 441952000070 active site 441952000071 Glycosyl hydrolases family 32 C terminal; Region: Glyco_hydro_32C; pfam08244 441952000072 Nitroreductase family. Members of this family utilize FMN as a cofactor and catalyze reduction of a variety of nitroaromatic compounds, including nitrofurans, nitrobenzens, nitrophenol, nitrobenzoate and quinones by using either NADH or NADPH as a source...; Region: Nitroreductase; cd02136 441952000073 putative FMN binding site [chemical binding]; other site 441952000074 Protein of unknown function (DUF1275); Region: DUF1275; cl01453 441952000075 Transmembrane amino acid transporter protein; Region: Aa_trans; cl15776 441952000076 aromatic amino acid transport protein; Region: araaP; TIGR00837 441952000077 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl15754 441952000078 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635 441952000079 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 441952000080 catalytic residue [active] 441952000081 Fusaric acid resistance protein-like; Region: FUSC_2; cl15844 441952000082 Transcriptional regulator [Transcription]; Region: LysR; COG0583 441952000083 Helix-turn-helix domains; Region: HTH; cl00088 441952000084 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 441952000085 putative effector binding pocket; other site 441952000086 dimerization interface [polypeptide binding]; other site 441952000087 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 441952000088 putative substrate translocation pore; other site 441952000089 drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710 441952000090 Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006 441952000091 dimer interface [polypeptide binding]; other site 441952000092 active site 441952000093 SmpA / OmlA family; Region: SmpA_OmlA; cl01095 441952000094 Ribosomal protein S20; Region: Ribosomal_S20p; cl00384 441952000095 GTP-binding protein LepA; Provisional; Region: PRK05433 441952000096 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 441952000097 G1 box; other site 441952000098 putative GEF interaction site [polypeptide binding]; other site 441952000099 GTP/Mg2+ binding site [chemical binding]; other site 441952000100 Switch I region; other site 441952000101 G2 box; other site 441952000102 G3 box; other site 441952000103 Switch II region; other site 441952000104 G4 box; other site 441952000105 G5 box; other site 441952000106 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 441952000107 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 441952000108 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 441952000109 tRNA methyl transferase; Region: tRNA_Me_trans; pfam03054 441952000110 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 441952000111 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 441952000112 active site 441952000113 catalytic residues [active] 441952000114 metal binding site [ion binding]; metal-binding site 441952000115 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 441952000116 homopentamer interface [polypeptide binding]; other site 441952000117 active site 441952000118 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09311 441952000119 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; cl00336 441952000120 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 441952000121 dimerization interface [polypeptide binding]; other site 441952000122 active site 441952000123 riboflavin synthase subunit alpha; Provisional; Region: PRK09289 441952000124 Lumazine binding domain; Region: Lum_binding; pfam00677 441952000125 Lumazine binding domain; Region: Lum_binding; pfam00677 441952000126 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 441952000127 catalytic motif [active] 441952000128 Zn binding site [ion binding]; other site 441952000129 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cl00161 441952000130 Protein of unknown function (DUF3568); Region: DUF3568; pfam12092 441952000131 Protein of unknown function (DUF3568); Region: DUF3568; pfam12092 441952000132 ClC chloride channel EriC. This domain is found in the EriC chloride transporters that mediate the extreme acid resistance response in eubacteria and archaea. This response allows bacteria to survive in the acidic environments by decarboxylation-linked...; Region: EriC; cd01031 441952000133 Voltage gated chloride channel; Region: Voltage_CLC; pfam00654 441952000134 Cl- selectivity filter; other site 441952000135 Cl- binding residues [ion binding]; other site 441952000136 pore gating glutamate residue; other site 441952000137 dimer interface [polypeptide binding]; other site 441952000138 H+/Cl- coupling transport residue; other site 441952000139 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 441952000140 pyridoxal 5'-phosphate binding site [chemical binding]; other site 441952000141 catalytic residue [active] 441952000142 tryptophan synthase subunit alpha; Provisional; Region: trpA; PRK13111 441952000143 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 441952000144 substrate binding site [chemical binding]; other site 441952000145 active site 441952000146 catalytic residues [active] 441952000147 heterodimer interface [polypeptide binding]; other site 441952000148 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 441952000149 Clp amino terminal domain; Region: Clp_N; pfam02861 441952000150 Clp amino terminal domain; Region: Clp_N; pfam02861 441952000151 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 441952000152 Walker A motif; other site 441952000153 ATP binding site [chemical binding]; other site 441952000154 Walker B motif; other site 441952000155 arginine finger; other site 441952000156 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 441952000157 Walker A motif; other site 441952000158 ATP binding site [chemical binding]; other site 441952000159 Walker B motif; other site 441952000160 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; cl11083 441952000161 N-acetylglucosamine-binding protein A; Reviewed; Region: PRK13211 441952000162 The GH18 (glycosyl hydrolase, family 18) type II chitinases hydrolyze chitin, an abundant polymer of beta-1,4-linked N-acetylglucosamine (GlcNAc) which is a major component of the cell wall of fungi and the exoskeleton of arthropods. Chitinases have...; Region: GH18_chitinase-like; cl10447 441952000163 active site 441952000164 phosphoribosylglycinamide formyltransferase 2; Validated; Region: purT; PRK09288 441952000165 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 441952000166 ATP-grasp domain; Region: ATP-grasp_4; cl03087 441952000167 Ferredoxin [Energy production and conversion]; Region: COG1146 441952000168 4Fe-4S binding domain; Region: Fer4; cl02805 441952000169 Domain of unknown function (DUF3470); Region: DUF3470; pfam11953 441952000170 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 441952000171 putative acyl-acceptor binding pocket; other site 441952000172 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 441952000173 putative acyl-acceptor binding pocket; other site 441952000174 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 441952000175 putative catalytic site [active] 441952000176 putative metal binding site [ion binding]; other site 441952000177 putative phosphate binding site [ion binding]; other site 441952000178 Na+/H+ antiporter 1; Region: Na_H_antiport_1; cl01133 441952000179 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 441952000180 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 441952000181 iron-sulfur cluster [ion binding]; other site 441952000182 [2Fe-2S] cluster binding site [ion binding]; other site 441952000183 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859 441952000184 Galactose mutarotase and related enzymes [Carbohydrate transport and metabolism]; Region: GalM; COG2017 441952000185 Aldose 1-epimerase, similar to Lactococcus lactis lacX; Region: Aldose_epim_lacX; cd09024 441952000186 active site 441952000187 catalytic residues [active] 441952000188 adenylosuccinate lyase; Provisional; Region: PRK07492 441952000189 Adenylsuccinate lyase (ASL)_subgroup 1; Region: Adenylsuccinate_lyase_1; cd01360 441952000190 tetramer interface [polypeptide binding]; other site 441952000191 active site 441952000192 ABC-type bacteriocin/lantibiotic exporters, contain an N-terminal double-glycine peptidase domain [Defense mechanisms]; Region: SunT; COG2274 441952000193 type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843 441952000194 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 441952000195 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 441952000196 Glu-tRNAGln amidotransferase C subunit; Region: Glu-tRNAGln; cl00495 441952000197 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 441952000198 Amidase; Region: Amidase; cl11426 441952000199 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 441952000200 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 441952000201 GatB domain; Region: GatB_Yqey; cl11497 441952000202 Protein of unknown function (DUF3573); Region: DUF3573; pfam12097 441952000203 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 441952000204 putative substrate translocation pore; other site 441952000205 Diaminopimelate decarboxylase [Amino acid transport and metabolism]; Region: LysA; COG0019 441952000206 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme MccE; Region: PLPDE_III_MccE_like; cd06841 441952000207 dimer interface [polypeptide binding]; other site 441952000208 active site 441952000209 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 441952000210 catalytic residues [active] 441952000211 substrate binding site [chemical binding]; other site 441952000212 drug efflux system protein MdtG; Provisional; Region: PRK09874 441952000213 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 441952000214 IucA / IucC family; Region: IucA_IucC; pfam04183 441952000215 Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276 441952000216 ferric uptake regulator; Provisional; Region: fur; PRK09462 441952000217 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 441952000218 metal binding site 2 [ion binding]; metal-binding site 441952000219 putative DNA binding helix; other site 441952000220 metal binding site 1 [ion binding]; metal-binding site 441952000221 dimer interface [polypeptide binding]; other site 441952000222 structural Zn2+ binding site [ion binding]; other site 441952000223 NADH-ubiquinone/plastoquinone oxidoreductase, chain 3; Region: Oxidored_q4; cl00535 441952000224 NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; cl15792 441952000225 Respiratory-chain NADH dehydrogenase, 30 Kd subunit; Region: Complex1_30kDa; cl15771 441952000226 Nickel-dependent hydrogenase; Region: NiFeSe_Hases; cl00417 441952000227 Respiratory-chain NADH dehydrogenase, 49 Kd subunit; Region: Complex1_49kDa; pfam00346 441952000228 Respiratory-chain NADH dehydrogenase 24 Kd subunit; Region: Complex1_24kDa; pfam01257 441952000229 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064 441952000230 putative dimer interface [polypeptide binding]; other site 441952000231 [2Fe-2S] cluster binding site [ion binding]; other site 441952000232 NADH-quinone oxidoreductase, F subunit; Region: nuoF_fam; TIGR01959 441952000233 Respiratory-chain NADH dehydrogenase 51 Kd subunit; Region: Complex1_51K; pfam01512 441952000234 SLBB domain; Region: SLBB; pfam10531 441952000235 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; cl11211 441952000236 NADH dehydrogenase subunit G; Validated; Region: PRK09129 441952000237 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 441952000238 catalytic loop [active] 441952000239 iron binding site [ion binding]; other site 441952000240 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; cl11210 441952000241 MopB_NDH-1_NuoG2: The second domain of the NuoG subunit of the NADH-quinone oxidoreductase/NADH dehydrogenase-1 (NDH-1), found in beta- and gammaproteobacteria. The NDH-1 is the first energy-transducting complex in the respiratory chain and functions as...; Region: MopB_NDH-1_NuoG2; cd02772 441952000242 NADH dehydrogenase; Region: NADHdh; cl00469 441952000243 NADH dehydrogenase subunit I; Provisional; Region: PRK05888 441952000244 4Fe-4S binding domain; Region: Fer4; cl02805 441952000245 4Fe-4S binding domain; Region: Fer4; cl02805 441952000246 NADH:ubiquinone oxidoreductase subunit J; Provisional; Region: PRK06638 441952000247 NADH-ubiquinone/plastoquinone oxidoreductase chain 4L; Region: Oxidored_q2; cl00492 441952000248 NADH:ubiquinone oxidoreductase subunit L; Reviewed; Region: PRK06590 441952000249 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662 441952000250 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; cl14187 441952000251 NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846 441952000252 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; cl14187 441952000253 NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777 441952000254 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; cl14187 441952000255 Membrane fusogenic activity; Region: BMFP; cl01115 441952000256 Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717 441952000257 substrate binding site [chemical binding]; other site 441952000258 active site 441952000259 ribosome maturation protein RimP; Reviewed; Region: PRK00092 441952000260 The eukaryotic Sm and Sm-like (LSm) proteins associate with RNA to form the core domain of the ribonucleoprotein particles involved in a variety of RNA processing events including pre-mRNA splicing, telomere replication, and mRNA degradation. Members of...; Region: Sm_like; cl00259 441952000261 The eukaryotic Sm and Sm-like (LSm) proteins associate with RNA to form the core domain of the ribonucleoprotein particles involved in a variety of RNA processing events including pre-mRNA splicing, telomere replication, and mRNA degradation. Members of...; Region: Sm_like; cl00259 441952000262 Sm1 motif; other site 441952000263 D3 - B interaction site; other site 441952000264 D1 - D2 interaction site; other site 441952000265 Hfq - Hfq interaction site; other site 441952000266 RNA binding pocket [nucleotide binding]; other site 441952000267 Sm2 motif; other site 441952000268 transcription elongation factor NusA; Validated; Region: nusA; PRK09202 441952000269 NusA N-terminal domain; Region: NusA_N; pfam08529 441952000270 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 441952000271 RNA binding site [nucleotide binding]; other site 441952000272 homodimer interface [polypeptide binding]; other site 441952000273 K homology RNA-binding domain, type I. KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains that...; Region: KH-I; cl00098 441952000274 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 441952000275 G-X-X-G motif; other site 441952000276 transcription termination factor NusA, C-terminal duplication; Region: nusA_Cterm_rpt; TIGR01954 441952000277 translation initiation factor IF-2; Validated; Region: infB; PRK05306 441952000278 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 441952000279 translation initiation factor IF-2; Region: IF-2; TIGR00487 441952000280 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 441952000281 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 441952000282 G1 box; other site 441952000283 putative GEF interaction site [polypeptide binding]; other site 441952000284 GTP/Mg2+ binding site [chemical binding]; other site 441952000285 Switch I region; other site 441952000286 G2 box; other site 441952000287 G3 box; other site 441952000288 Switch II region; other site 441952000289 G4 box; other site 441952000290 G5 box; other site 441952000291 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 441952000292 Translation-initiation factor 2; Region: IF-2; pfam11987 441952000293 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 441952000294 Ribosome-binding factor A; Region: RBFA; cl00542 441952000295 histidyl-tRNA synthetase; Region: hisS; TIGR00442 441952000296 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: HisRS-like_core; cd00773 441952000297 dimer interface [polypeptide binding]; other site 441952000298 motif 1; other site 441952000299 active site 441952000300 motif 2; other site 441952000301 motif 3; other site 441952000302 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 441952000303 anticodon binding site; other site 441952000304 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 441952000305 phosphoglycerate transporter family protein; Region: 2A0104; TIGR00881 441952000306 putative substrate translocation pore; other site 441952000307 Predicted ATPase [General function prediction only]; Region: COG1485 441952000308 23S rRNA pseudouridylate synthase C; Provisional; Region: PRK11025 441952000309 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 441952000310 RNA binding surface [nucleotide binding]; other site 441952000311 PseudoU_synth_RsuA/RluD: Pseudouridine synthase, RsuA/RluD family. This group is comprised of eukaryotic, bacterial and archeal proteins similar to eight site specific Escherichia coli pseudouridine synthases: RsuA, RluA, RluB, RluC, RluD, RluE, RluF and...; Region: PseudoU_synth_RluCD_like; cd02869 441952000312 active site 441952000313 Major Facilitator Superfamily; Region: MFS_1; pfam07690 441952000314 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 441952000315 putative substrate translocation pore; other site 441952000316 ATP synthase A chain; Region: ATP-synt_A; cl00413 441952000317 ATP synthase subunit C; Region: ATP-synt_C; cl00466 441952000318 Plant ATP synthase F0; Region: YMF19; cl07975 441952000319 ATP synthase B/B' CF(0); Region: ATP-synt_B; pfam00430 441952000320 Plant ATP synthase F0; Region: YMF19; cl07975 441952000321 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 441952000322 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 441952000323 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; cl15275 441952000324 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 441952000325 beta subunit interaction interface [polypeptide binding]; other site 441952000326 Walker A motif; other site 441952000327 ATP binding site [chemical binding]; other site 441952000328 Walker B motif; other site 441952000329 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 441952000330 ATP synthase; Region: ATP-synt; cl00365 441952000331 F0F1 ATP synthase subunit gamma; Provisional; Region: PRK13422 441952000332 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 441952000333 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; cl15275 441952000334 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 441952000335 alpha subunit interaction interface [polypeptide binding]; other site 441952000336 Walker A motif; other site 441952000337 ATP binding site [chemical binding]; other site 441952000338 Walker B motif; other site 441952000339 inhibitor binding site; inhibition site 441952000340 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 441952000341 F0F1 ATP synthase subunit epsilon; Provisional; Region: atpC; PRK13452 441952000342 ATP synthase, Delta/Epsilon chain, beta-sandwich domain; Region: ATP-synt_DE_N; cl10033 441952000343 The GH18 (glycosyl hydrolase, family 18) type II chitinases hydrolyze chitin, an abundant polymer of beta-1,4-linked N-acetylglucosamine (GlcNAc) which is a major component of the cell wall of fungi and the exoskeleton of arthropods. Chitinases have...; Region: GH18_chitinase-like; cl10447 441952000344 GH18 domain of Chitinase D (ChiD). ChiD, a chitinase found in Bacillus circulans, hydrolyzes the 1,4-beta-linkages of N-acetylglucosamine in chitin and chitodextrins. The domain architecture of ChiD includes a catalytic glycosyl hydrolase family 18; Region: GH18_chitinase_D-like; cd02871 441952000345 putative active site [active] 441952000346 Glycosyl hydrolases family 18; Region: Glyco_hydro_18; pfam00704 441952000347 N-acetylglucosamine-binding protein A; Reviewed; Region: PRK13211 441952000348 Glutaredoxin (GRX) family, PKC-interacting cousin of TRX (PICOT)-like subfamily; composed of PICOT and GRX-PICOT-like proteins. The non-PICOT members of this family contain only the GRX-like domain, whereas PICOT contains an N-terminal TRX-like domain...; Region: GRX_PICOT_like; cd03028 441952000349 putative GSH binding site [chemical binding]; other site 441952000350 catalytic residues [active] 441952000351 superoxide dismutase; Provisional; Region: PRK10543 441952000352 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 441952000353 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 441952000354 muropeptide transporter; Validated; Region: ampG; PRK11010 441952000355 muropeptide transporter; Reviewed; Region: ampG; PRK11902 441952000356 Escherichia coli (Ec) citrate synthase (CS) GltA_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). The overall CS...; Region: EcCS_like; cd06114 441952000357 dimer interface [polypeptide binding]; other site 441952000358 Citrate synthase; Region: Citrate_synt; pfam00285 441952000359 active site 441952000360 citrylCoA binding site [chemical binding]; other site 441952000361 NADH binding [chemical binding]; other site 441952000362 cationic pore residues; other site 441952000363 oxalacetate/citrate binding site [chemical binding]; other site 441952000364 coenzyme A binding site [chemical binding]; other site 441952000365 catalytic triad [active] 441952000366 Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase C (SdhC) subunit; composed of bacterial SdhC and eukaryotic large cytochrome b binding (CybL) proteins. SQR catalyzes the oxidation of succinate to fumarate coupled to the...; Region: SQR_TypeC_SdhC; cd03499 441952000367 Iron-sulfur protein interface; other site 441952000368 proximal quinone binding site [chemical binding]; other site 441952000369 SdhD (CybS) interface [polypeptide binding]; other site 441952000370 proximal heme binding site [chemical binding]; other site 441952000371 Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase D (SdhD) subunit; SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. E. coli SQR, a member of this subfamily, reduces the...; Region: SQR_TypeC_SdhD; cd03494 441952000372 SdhC subunit interface [polypeptide binding]; other site 441952000373 proximal heme binding site [chemical binding]; other site 441952000374 cardiolipin binding site; other site 441952000375 Iron-sulfur protein interface; other site 441952000376 proximal quinone binding site [chemical binding]; other site 441952000377 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK08958 441952000378 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 441952000379 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 441952000380 succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK05950 441952000381 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cl00159 441952000382 2-oxoglutarate dehydrogenase E1 component; Reviewed; Region: sucA; PRK09404 441952000383 Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016 441952000384 TPP-binding site [chemical binding]; other site 441952000385 Pyrimidine (PYR) binding domain of thiamine pyrophosphate (TPP)-dependent enzymes; Region: TPP_enzyme_PYR; cl11410 441952000386 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 441952000387 E3 interaction surface; other site 441952000388 lipoyl attachment site [posttranslational modification]; other site 441952000389 dihydrolipoamide succinyltransferase; Validated; Region: PRK05704 441952000390 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 441952000391 E3 interaction surface; other site 441952000392 lipoyl attachment site [posttranslational modification]; other site 441952000393 e3 binding domain; Region: E3_binding; pfam02817 441952000394 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; cl02008 441952000395 Adenine/guanine phosphoribosyltransferases and related PRPP-binding proteins [Nucleotide transport and metabolism]; Region: Apt; COG0503 441952000396 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 441952000397 active site 441952000398 phosphoglucosamine mutase; Provisional; Region: glmM; PRK14320 441952000399 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 441952000400 active site 441952000401 substrate binding site [chemical binding]; other site 441952000402 metal binding site [ion binding]; metal-binding site 441952000403 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 441952000404 substrate binding site [chemical binding]; other site 441952000405 dimer interface [polypeptide binding]; other site 441952000406 catalytic triad [active] 441952000407 Preprotein translocase SecG subunit; Region: SecG; cl09123 441952000408 HemN family oxidoreductase; Provisional; Region: PRK05660 441952000409 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 441952000410 FeS/SAM binding site; other site 441952000411 HemN C-terminal domain; Region: HemN_C; pfam06969 441952000412 GtrA-like protein; Region: GtrA; cl00971 441952000413 Dyp-type peroxidase family; Region: Dyp_perox; cl01067 441952000414 aconitate hydratase; Validated; Region: PRK09277 441952000415 Aconitase A catalytic domain; Region: AcnA_IRP; cd01586 441952000416 substrate binding site [chemical binding]; other site 441952000417 ligand binding site [chemical binding]; other site 441952000418 Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580 441952000419 substrate binding site [chemical binding]; other site 441952000420 Protein of unknown function (DUF3429); Region: DUF3429; pfam11911 441952000421 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 441952000422 Predicted nucleoside-diphosphate sugar epimerase [General function prediction only]; Region: COG1090 441952000423 NAD(P) binding site [chemical binding]; other site 441952000424 active site 441952000425 sensor protein QseC; Provisional; Region: PRK10337 441952000426 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 441952000427 dimer interface [polypeptide binding]; other site 441952000428 phosphorylation site [posttranslational modification] 441952000429 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 441952000430 ATP binding site [chemical binding]; other site 441952000431 Mg2+ binding site [ion binding]; other site 441952000432 G-X-G motif; other site 441952000433 LD-Carboxypeptidase, a serine protease, includes microcin C7 self immunity protein; Region: Peptidase_S66; cd07025 441952000434 dimer interface [polypeptide binding]; other site 441952000435 catalytic triad [active] 441952000436 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 441952000437 phosphoglycerate transporter family protein; Region: 2A0104; TIGR00881 441952000438 putative substrate translocation pore; other site 441952000439 multidrug efflux protein; Reviewed; Region: PRK09579 441952000440 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 441952000441 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 441952000442 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 441952000443 Disulfide bond formation protein DsbB; Region: DsbB; cl00649 441952000444 tRNA CCA-pyrophosphorylase; Provisional; Region: PRK13296 441952000445 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 441952000446 active site 441952000447 NTP binding site [chemical binding]; other site 441952000448 metal binding triad [ion binding]; metal-binding site 441952000449 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 441952000450 lipid A export permease/ATP-binding protein MsbA; Region: MsbA_lipidA; TIGR02203 441952000451 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 441952000452 MsbA is an essential ABC transporter, closely related to eukaryotic MDR proteins. ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars, ions, peptides, and more complex organic...; Region: ABCC_MsbA; cd03251 441952000453 Walker A/P-loop; other site 441952000454 ATP binding site [chemical binding]; other site 441952000455 Q-loop/lid; other site 441952000456 ABC transporter signature motif; other site 441952000457 Walker B; other site 441952000458 D-loop; other site 441952000459 H-loop/switch region; other site 441952000460 Tetraacyldisaccharide-1-P 4'-kinase; Region: LpxK; cl03652 441952000461 Tetraacyldisaccharide-1-P 4'-kinase [Cell envelope biogenesis, outer membrane]; Region: LpxK; COG1663 441952000462 DNA polymerase I; Provisional; Region: PRK05755 441952000463 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 441952000464 active site 441952000465 metal binding site 1 [ion binding]; metal-binding site 441952000466 putative 5' ssDNA interaction site; other site 441952000467 metal binding site 3; metal-binding site 441952000468 metal binding site 2 [ion binding]; metal-binding site 441952000469 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 441952000470 putative DNA binding site [nucleotide binding]; other site 441952000471 putative metal binding site [ion binding]; other site 441952000472 DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase I and similar bacterial family-A DNA polymerases; Region: DNA_polA_I_Ecoli_like_exo; cd06139 441952000473 active site 441952000474 catalytic site [active] 441952000475 substrate binding site [chemical binding]; other site 441952000476 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 441952000477 active site 441952000478 DNA binding site [nucleotide binding] 441952000479 catalytic site [active] 441952000480 Type III pantothenate kinase; Region: Pan_kinase; cl09130 441952000481 Sulfatase; Region: Sulfatase; cl10460 441952000482 Metalloenzyme superfamily; Region: Metalloenzyme; pfam01676 441952000483 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 441952000484 intersubunit interface [polypeptide binding]; other site 441952000485 active site 441952000486 catalytic residue [active] 441952000487 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 441952000488 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 441952000489 Nucleoside recognition; Region: Gate; cl00486 441952000490 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 441952000491 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 441952000492 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 441952000493 Nucleoside recognition; Region: Gate; cl00486 441952000494 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 441952000495 thymidylate kinase; Validated; Region: tmk; PRK00698 441952000496 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 441952000497 TMP-binding site; other site 441952000498 ATP-binding site [chemical binding]; other site 441952000499 peptide chain release factor 3; Provisional; Region: prfC; PRK00741 441952000500 Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169 441952000501 G1 box; other site 441952000502 putative GEF interaction site [polypeptide binding]; other site 441952000503 GTP/Mg2+ binding site [chemical binding]; other site 441952000504 Switch I region; other site 441952000505 G2 box; other site 441952000506 G3 box; other site 441952000507 Switch II region; other site 441952000508 G4 box; other site 441952000509 G5 box; other site 441952000510 RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689 441952000511 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cl00107 441952000512 putative PEP-CTERM system TPR-repeat lipoprotein; Region: PEP_TPR_lipo; TIGR02917 441952000513 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 441952000514 SRP54-type protein, helical bundle domain; Region: SRP54_N; cl03758 441952000515 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 441952000516 GTP binding site [chemical binding]; other site 441952000517 DNA-dependent helicase II; Provisional; Region: uvrD; PRK11773 441952000518 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 441952000519 Family description; Region: UvrD_C_2; cl15862 441952000520 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 441952000521 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 441952000522 peptide binding site [polypeptide binding]; other site 441952000523 oligopeptide transporter ATP-binding component; Provisional; Region: oppD; PRK09473 441952000524 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 441952000525 Walker A/P-loop; other site 441952000526 ATP binding site [chemical binding]; other site 441952000527 Q-loop/lid; other site 441952000528 ABC transporter signature motif; other site 441952000529 Walker B; other site 441952000530 D-loop; other site 441952000531 H-loop/switch region; other site 441952000532 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 441952000533 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 441952000534 putative substrate translocation pore; other site 441952000535 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 441952000536 putative substrate translocation pore; other site 441952000537 Major Facilitator Superfamily; Region: MFS_1; pfam07690 441952000538 glycerol kinase; Provisional; Region: glpK; PRK00047 441952000539 Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786 441952000540 N- and C-terminal domain interface [polypeptide binding]; other site 441952000541 active site 441952000542 MgATP binding site [chemical binding]; other site 441952000543 catalytic site [active] 441952000544 metal binding site [ion binding]; metal-binding site 441952000545 glycerol binding site [chemical binding]; other site 441952000546 homotetramer interface [polypeptide binding]; other site 441952000547 homodimer interface [polypeptide binding]; other site 441952000548 FBP binding site [chemical binding]; other site 441952000549 protein IIAGlc interface [polypeptide binding]; other site 441952000550 Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578 441952000551 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333 441952000552 amphipathic channel; other site 441952000553 Asn-Pro-Ala signature motifs; other site 441952000554 Mechanosensitive ion channel; Region: MS_channel; pfam00924 441952000555 elongation factor Tu; Reviewed; Region: PRK00049 441952000556 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 441952000557 G1 box; other site 441952000558 GEF interaction site [polypeptide binding]; other site 441952000559 GTP/Mg2+ binding site [chemical binding]; other site 441952000560 Switch I region; other site 441952000561 G2 box; other site 441952000562 G3 box; other site 441952000563 Switch II region; other site 441952000564 G4 box; other site 441952000565 G5 box; other site 441952000566 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 441952000567 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 441952000568 Antibiotic Binding Site [chemical binding]; other site 441952000569 SecE/Sec61-gamma subunits of protein translocation complex; Region: SecE; cl00481 441952000570 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 441952000571 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 441952000572 putative homodimer interface [polypeptide binding]; other site 441952000573 KOW motif; Region: KOW; cl00354 441952000574 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 441952000575 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 441952000576 23S rRNA interface [nucleotide binding]; other site 441952000577 L7/L12 interface [polypeptide binding]; other site 441952000578 putative thiostrepton binding site; other site 441952000579 L25 interface [polypeptide binding]; other site 441952000580 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 441952000581 mRNA/rRNA interface [nucleotide binding]; other site 441952000582 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 441952000583 23S rRNA interface [nucleotide binding]; other site 441952000584 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 441952000585 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 441952000586 core dimer interface [polypeptide binding]; other site 441952000587 peripheral dimer interface [polypeptide binding]; other site 441952000588 L10 interface [polypeptide binding]; other site 441952000589 L11 interface [polypeptide binding]; other site 441952000590 putative EF-Tu interaction site [polypeptide binding]; other site 441952000591 putative EF-G interaction site [polypeptide binding]; other site 441952000592 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl04593 441952000593 DNA-directed RNA polymerase subunit beta'; Provisional; Region: PRK00566 441952000594 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 441952000595 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 441952000596 RPB12 interaction site [polypeptide binding]; other site 441952000597 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl04593 441952000598 RPB11 interaction site [polypeptide binding]; other site 441952000599 RPB12 interaction site [polypeptide binding]; other site 441952000600 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 441952000601 RPB3 interaction site [polypeptide binding]; other site 441952000602 RPB1 interaction site [polypeptide binding]; other site 441952000603 RPB11 interaction site [polypeptide binding]; other site 441952000604 RPB10 interaction site [polypeptide binding]; other site 441952000605 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 441952000606 DNA-directed RNA polymerase, beta' subunit/160 kD subunit [Transcription]; Region: RpoC; COG0086 441952000607 RNA polymerase Rpb1, domain 2; Region: RNA_pol_Rpb1_2; cl11591 441952000608 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 441952000609 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 441952000610 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 441952000611 cleft; other site 441952000612 Rpb1 - Rpb6 interaction site [polypeptide binding]; other site 441952000613 Rpb1 - Rpb5 interaction site [polypeptide binding]; other site 441952000614 DNA-directed RNA polymerase, beta' subunit, predominant form; Region: rpoC_TIGR; TIGR02386 441952000615 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 441952000616 DNA binding site [nucleotide binding] 441952000617 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 441952000618 Protein of unknown function (DUF1049); Region: DUF1049; cl01539 441952000619 UGMP family protein; Validated; Region: PRK09604 441952000620 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl14000 441952000621 The Delta9 Fatty Acid Desaturase (Delta9-FADS)-like CD includes the delta-9 and delta-11 acyl CoA desaturases found in various eukaryotes including vertebrates, insects, higher plants, and fungi. The delta-9 acyl-lipid desaturases are found in a wide...; Region: Delta9-FADS-like; cd03505 441952000622 Di-iron ligands [ion binding]; other site 441952000623 The Delta9 Fatty Acid Desaturase (Delta9-FADS)-like CD includes the delta-9 and delta-11 acyl CoA desaturases found in various eukaryotes including vertebrates, insects, higher plants, and fungi. The delta-9 acyl-lipid desaturases are found in a wide...; Region: Delta9-FADS-like; cd03505 441952000624 S-adenosylmethionine synthetase; Validated; Region: PRK05250 441952000625 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 441952000626 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 441952000627 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 441952000628 Ribosomal protein S16; Region: Ribosomal_S16; cl00368 441952000629 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK14591 441952000630 RimM N-terminal domain; Region: RimM; pfam01782 441952000631 Photosynthetic reaction center (RC) complex, subunit H; RC is an integral membrane protein-pigment complex which catalyzes light-induced reduction of ubiquinone to ubiquinol, generating a transmembrane electrochemical gradient of protons used to produce...; Region: PRCH; cl09959 441952000632 tRNA (Guanine-1)-methyltransferase; Region: tRNA_m1G_MT; cl00407 441952000633 Ribosomal protein L19; Region: Ribosomal_L19; cl00406 441952000634 site-specific tyrosine recombinase XerD; Reviewed; Region: xerD; PRK00283 441952000635 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 441952000636 DNA binding site [nucleotide binding] 441952000637 Int/Topo IB signature motif; other site 441952000638 active site 441952000639 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 441952000640 Diadenosine tetraphosphate (Ap4A) hydrolase is a member of the Nudix hydrolase superfamily. Members of this family are well represented in a variety of prokaryotic and eukaryotic organisms. Phylogenetic analysis reveals two distinct subgroups where plant...; Region: Ap4A_hydrolase_plant_like; cd03671 441952000641 putative active site [active] 441952000642 Ap4A binding site [chemical binding]; other site 441952000643 nudix motif; other site 441952000644 putative metal binding site [ion binding]; other site 441952000645 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474 441952000646 active site 441952000647 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 441952000648 amidase catalytic site [active] 441952000649 Zn binding residues [ion binding]; other site 441952000650 substrate binding site [chemical binding]; other site 441952000651 DNA topoisomerase IV subunit B; Reviewed; Region: PRK05559 441952000652 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 441952000653 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 441952000654 anchoring element; other site 441952000655 dimer interface [polypeptide binding]; other site 441952000656 ATP binding site [chemical binding]; other site 441952000657 Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718 441952000658 active site 441952000659 metal binding site [ion binding]; metal-binding site 441952000660 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 441952000661 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 441952000662 drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710 441952000663 putative substrate translocation pore; other site 441952000664 outer membrane assembly lipoprotein YfgL; Region: assembly_YfgL; TIGR03300 441952000665 Beta-barrel assembly machinery (Bam) complex component B and related proteins; Region: BamB_YfgL; cd10276 441952000666 Trp docking motif [polypeptide binding]; other site 441952000667 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2976 441952000668 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 441952000669 TPR motif; other site 441952000670 binding surface 441952000671 glutamyl-tRNA reductase; Provisional; Region: PRK13940 441952000672 NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213 441952000673 tRNA; other site 441952000674 putative tRNA binding site [nucleotide binding]; other site 441952000675 putative NADP binding site [chemical binding]; other site 441952000676 Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745 441952000677 peptide chain release factor 1; Validated; Region: prfA; PRK00591 441952000678 RF-1 domain; Region: RF-1; cl02875 441952000679 RF-1 domain; Region: RF-1; cl02875 441952000680 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 441952000681 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 441952000682 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 441952000683 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 441952000684 ring oligomerisation interface [polypeptide binding]; other site 441952000685 ATP/Mg binding site [chemical binding]; other site 441952000686 stacking interactions; other site 441952000687 hinge regions; other site 441952000688 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 441952000689 oligomerisation interface [polypeptide binding]; other site 441952000690 mobile loop; other site 441952000691 roof hairpin; other site 441952000692 Predicted membrane protein [Function unknown]; Region: COG4125 441952000693 Bacterial Transmembrane Pair family; Region: BTP; pfam05232 441952000694 Protein of unknown function (DUF328); Region: DUF328; cl01143 441952000695 FinO bacterial conjugation repressor domain; the basic protein FinO is part of the the two component FinOP system which is responsible for repressing bacterial conjugation; the FinOP system represses the transfer (tra) operon of the F-plasmid which...; Region: FinO_conjug_rep; cl15270 441952000696 Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168 441952000697 Cation transport protein; Region: TrkH; cl10514 441952000698 lipoprotein chaperone; Reviewed; Region: lolA; PRK00031 441952000699 Outer membrane lipoprotein carrier protein LolA; Region: LolA; cl01065 441952000700 Domain of unknown function (DUF4117); Region: DUF4117; pfam13491 441952000701 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 441952000702 Ftsk gamma domain; Region: Ftsk_gamma; cl09645 441952000703 PAP2_like_6 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which mainly contains bacterial proteins, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_6; cd03396 441952000704 active site 441952000705 Amino acid transporters [Amino acid transport and metabolism]; Region: LysP; COG0833 441952000706 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2945 441952000707 Bacterial fructose-1,6-bisphosphatase, glpX-encoded. A dimeric enzyme dependent on Mg(2+). glpX-encoded FPBase (FBPase class II) differs from other members of the inositol-phosphatase superfamily by permutation of secondary structure elements. The core...; Region: FBPase_glpX; cd01516 441952000708 putative active site [active] 441952000709 Glycosyltransferases, probably involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG1215 441952000710 CESA_like is the cellulose synthase superfamily; Region: CESA_like; cd06423 441952000711 DXD motif; other site 441952000712 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 441952000713 Domain of unknown function DUF21; Region: DUF21; pfam01595 441952000714 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 441952000715 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 441952000716 multidrug resistance protein D; Provisional; Region: emrD; PRK11652 441952000717 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 441952000718 putative substrate translocation pore; other site 441952000719 HemK family putative methylases; Region: hemK_fam; TIGR00536 441952000720 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 441952000721 S-adenosylmethionine binding site [chemical binding]; other site 441952000722 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 441952000723 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 441952000724 active site 441952000725 HIGH motif; other site 441952000726 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 441952000727 KMSKS motif; other site 441952000728 Anticodon-binding domain of cysteinyl tRNA synthetases; Region: Anticodon_Ia_Cys; cd07963 441952000729 tRNA binding surface [nucleotide binding]; other site 441952000730 anticodon binding site; other site 441952000731 Domain of unknown function (DUF4282); Region: DUF4282; pfam14110 441952000732 Spore germination protein; Region: Spore_permease; cl15802 441952000733 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 441952000734 bifunctional 3-demethylubiquinone-9 3-methyltransferase/ 2-octaprenyl-6-hydroxy phenol methylase; Provisional; Region: PRK05134 441952000735 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 441952000736 VacJ like lipoprotein; Region: VacJ; cl01073 441952000737 Helix-turn-helix domains; Region: HTH; cl00088 441952000738 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 441952000739 short chain dehydrogenase; Validated; Region: PRK06182 441952000740 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 441952000741 NADP binding site [chemical binding]; other site 441952000742 active site 441952000743 steroid binding site; other site 441952000744 putative glutamate/gamma-aminobutyrate antiporter; Region: put_Glu_GABA_T; TIGR03813 441952000745 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 441952000746 Chagasin family peptidase inhibitor I42; Region: Inhibitor_I42; cl02325 441952000747 Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron transfer between NADP(H) and electron carrier proteins such as ferredoxin and flavodoxin. Isoforms of these flavoproteins (i.e. having a non-covalently...; Region: FNR1; cd06195 441952000748 ferredoxin-NADP reductase; Provisional; Region: PRK10926 441952000749 FAD binding pocket [chemical binding]; other site 441952000750 FAD binding motif [chemical binding]; other site 441952000751 phosphate binding motif [ion binding]; other site 441952000752 beta-alpha-beta structure motif; other site 441952000753 NAD binding pocket [chemical binding]; other site 441952000754 Ribosomal protein L31; Region: Ribosomal_L31; cl00377 441952000755 Glutamate-cysteine ligase; Region: Glu_cys_ligase; cl15791 441952000756 Uncharacterized membrane protein, putative virulence factor [General function prediction only]; Region: MviN; COG0728 441952000757 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 441952000758 Uncharacterized P-loop hydrolase UPF0079; Region: UPF0079; cl00520 441952000759 Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285 441952000760 acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654 441952000761 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl15772 441952000762 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 441952000763 active site 441952000764 multimer interface [polypeptide binding]; other site 441952000765 CTP synthetase; Validated; Region: pyrG; PRK05380 441952000766 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 441952000767 Catalytic site [active] 441952000768 active site 441952000769 UTP binding site [chemical binding]; other site 441952000770 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 441952000771 active site 441952000772 putative oxyanion hole; other site 441952000773 catalytic triad [active] 441952000774 Glycosyltransferase sugar-binding region containing DXD motif; Region: Gly_transf_sug; pfam04488 441952000775 heat shock protein 90; Provisional; Region: PRK05218 441952000776 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 441952000777 ATP binding site [chemical binding]; other site 441952000778 Mg2+ binding site [ion binding]; other site 441952000779 G-X-G motif; other site 441952000780 Fumarate hydratase (Fumerase); Region: Fumerase; cl00851 441952000781 Fumarase C-terminus; Region: Fumerase_C; cl00795 441952000782 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 441952000783 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 441952000784 ssDNA binding site; other site 441952000785 generic binding surface II; other site 441952000786 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 441952000787 ATP binding site [chemical binding]; other site 441952000788 putative Mg++ binding site [ion binding]; other site 441952000789 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 441952000790 nucleotide binding region [chemical binding]; other site 441952000791 ATP-binding site [chemical binding]; other site 441952000792 Prokaryotic lipoprotein-attachment site; Region: LPAM_2; cl02361 441952000793 Ribosomal L28 family; Region: Ribosomal_L28; cl00367 441952000794 Ribosomal protein L33; Region: Ribosomal_L33; cl00383 441952000795 septum formation inhibitor; Reviewed; Region: minC; PRK04804 441952000796 Septum formation inhibitor MinC, N-terminal domain; Region: MinC_N; pfam05209 441952000797 Septum formation inhibitor MinC, C-terminal domain; Region: MinC_C; pfam03775 441952000798 Septum formation inhibitor-activating ATPase [Cell division and chromosome partitioning]; Region: MinD; COG2894 441952000799 Bacterial cell division requires the formation of a septum at mid-cell. The site is determined by the min operon products MinC, MinD and MinE. MinC is a nonspecific inhibitor of the septum protein FtsZ. MinE is the supressor of MinC. MinD plays a pivotal...; Region: MinD; cd02036 441952000800 Switch I; other site 441952000801 Switch II; other site 441952000802 Septum formation topological specificity factor MinE; Region: MinE; cl00538 441952000803 ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127 441952000804 ABC (ATP-binding cassette) transport system involved in resistant to organic solvents; ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars, ions, peptides, and more complex...; Region: ABC_Org_Solvent_Resistant; cd03261 441952000805 Walker A/P-loop; other site 441952000806 ATP binding site [chemical binding]; other site 441952000807 Q-loop/lid; other site 441952000808 ABC transporter signature motif; other site 441952000809 Walker B; other site 441952000810 D-loop; other site 441952000811 H-loop/switch region; other site 441952000812 Permease; Region: Permease; cl00510 441952000813 ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463 441952000814 mce related protein; Region: MCE; pfam02470 441952000815 Toluene tolerance, Ttg2; Region: Tol_Tol_Ttg2; cl01074 441952000816 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 441952000817 anti sigma factor interaction site; other site 441952000818 regulatory phosphorylation site [posttranslational modification]; other site 441952000819 BolA-like protein; Region: BolA; cl00386 441952000820 Restriction endonuclease [Defense mechanisms]; Region: COG3587 441952000821 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 441952000822 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 441952000823 ligand binding site [chemical binding]; other site 441952000824 active site 441952000825 UGI interface [polypeptide binding]; other site 441952000826 catalytic site [active] 441952000827 DNA gyrase subunit A; Validated; Region: PRK05560 441952000828 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes in DNA...; Region: TOP4c; cd00187 441952000829 CAP-like domain; other site 441952000830 active site 441952000831 primary dimer interface [polypeptide binding]; other site 441952000832 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 441952000833 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 441952000834 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 441952000835 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 441952000836 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 441952000837 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 441952000838 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447 441952000839 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 441952000840 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 441952000841 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 441952000842 outer membrane protein assembly complex, YaeT protein; Region: OM_YaeT; TIGR03303 441952000843 Surface antigen variable number repeat; Region: Surf_Ag_VNR; cl10520 441952000844 Surface antigen variable number repeat; Region: Surf_Ag_VNR; cl10520 441952000845 Surface antigen variable number repeat; Region: Surf_Ag_VNR; cl10520 441952000846 Surface antigen variable number repeat; Region: Surf_Ag_VNR; cl10520 441952000847 Surface antigen; Region: Bac_surface_Ag; cl03097 441952000848 periplasmic chaperone; Provisional; Region: PRK10780 441952000849 Outer membrane protein (OmpH-like); Region: OmpH; pfam03938 441952000850 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Provisional; Region: lpxD; PRK00892 441952000851 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase, LpxD; Region: LpxD; pfam04613 441952000852 UDP-3-O-acyl-glucosamine N-acyltransferase (LpxD): The enzyme catalyzes the transfer of 3-hydroxymyristic acid or 3-hydroxy-arachidic acid, depending on the organism, from the acyl carrier protein (ACP) to UDP-3-O-acyl-glucosamine to produce UDP-2; Region: LbH_LpxD; cd03352 441952000853 trimer interface [polypeptide binding]; other site 441952000854 active site 441952000855 UDP-GlcNAc binding site [chemical binding]; other site 441952000856 lipid binding site [chemical binding]; lipid-binding site 441952000857 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 441952000858 UDP-N-acetylglucosamine acyltransferase; Provisional; Region: PRK05289 441952000859 UDP-N-acetylglucosamine O-acyltransferase (UDP-GlcNAc acyltransferase): Proteins in this family catalyze the transfer of (R)-3-hydroxymyristic acid from its acyl carrier protein thioester to UDP-GlcNAc. It is the first enzyme in the lipid A biosynthetic...; Region: LbH_UDP-GlcNAc_AT; cd03351 441952000860 active site 441952000861 lipid-A-disaccharide synthase; Reviewed; Region: lpxB; PRK00025 441952000862 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 441952000863 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 441952000864 active site 441952000865 Phosphatidylserine synthase [Lipid metabolism]; Region: PssA; COG1183 441952000866 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 441952000867 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 441952000868 substrate binding pocket [chemical binding]; other site 441952000869 chain length determination region; other site 441952000870 substrate-Mg2+ binding site; other site 441952000871 catalytic residues [active] 441952000872 aspartate-rich region 1; other site 441952000873 active site lid residues [active] 441952000874 aspartate-rich region 2; other site 441952000875 3-deoxy-D-manno-octulosonic-acid transferase; Reviewed; Region: PRK05749 441952000876 3-Deoxy-D-manno-octulosonic-acid transferase (kdotransferase); Region: Glycos_transf_N; pfam04413 441952000877 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 441952000878 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 441952000879 active site 441952000880 dimerization interface [polypeptide binding]; other site 441952000881 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880 441952000882 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 441952000883 DNA-binding transcriptional regulator QseB; Provisional; Region: PRK10336 441952000884 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 441952000885 active site 441952000886 phosphorylation site [posttranslational modification] 441952000887 intermolecular recognition site; other site 441952000888 dimerization interface [polypeptide binding]; other site 441952000889 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 441952000890 DNA binding site [nucleotide binding] 441952000891 signal peptidase I; Provisional; Region: PRK10861 441952000892 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 441952000893 Catalytic site [active] 441952000894 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 441952000895 ribonuclease III; Reviewed; Region: rnc; PRK00102 441952000896 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 441952000897 dimerization interface [polypeptide binding]; other site 441952000898 active site 441952000899 metal binding site [ion binding]; metal-binding site 441952000900 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 441952000901 dsRNA binding site [nucleotide binding]; other site 441952000902 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK05033 441952000903 PseudoU_synth_EcTruB: Pseudouridine synthase, Escherichia coli TruB like. This group consists of bacterial pseudouridine synthases similar to E. coli TruB and Mycobacterium tuberculosis TruB. Pseudouridine synthases catalyze the isomerization of specific...; Region: PseudoU_synth_EcTruB; cd02573 441952000904 RNA binding site [nucleotide binding]; other site 441952000905 active site 441952000906 ribonuclease R; Region: RNase_R; TIGR02063 441952000907 RNB domain; Region: RNB; pfam00773 441952000908 S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase play an important...; Region: S1_RNase_R; cd04471 441952000909 RNA binding site [nucleotide binding]; other site 441952000910 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 441952000911 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 441952000912 NAD(P) binding site [chemical binding]; other site 441952000913 active site 441952000914 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 441952000915 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 441952000916 active site 441952000917 phosphorylation site [posttranslational modification] 441952000918 intermolecular recognition site; other site 441952000919 dimerization interface [polypeptide binding]; other site 441952000920 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 441952000921 DNA binding site [nucleotide binding] 441952000922 TolB amino-terminal domain; Region: TolB_N; cl00639 441952000923 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3014 441952000924 N-Dimethylarginine dimethylaminohydrolase [Amino acid transport and metabolism]; Region: COG1834 441952000925 Amidinotransferase; Region: Amidinotransf; cl12043 441952000926 putative nicotinate phosphoribosyltransferase; Provisional; Region: PRK09198 441952000927 pre-B-cell colony-enhancing factor (PBEF)-like. The mammalian members of this group of nicotinate phosphoribosyltransferases (NAPRTases) were originally identified as genes whose expression is upregulated upon activation in lymphoid cells. In general; Region: PBEF_like; cd01569 441952000928 active site 441952000929 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 441952000930 CoenzymeA binding site [chemical binding]; other site 441952000931 subunit interaction site [polypeptide binding]; other site 441952000932 PHB binding site; other site 441952000933 acetyl-CoA acetyltransferase; Provisional; Region: PRK09052 441952000934 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 441952000935 dimer interface [polypeptide binding]; other site 441952000936 active site 441952000937 Acyl CoA binding protein (ACBP) binds thiol esters of long fatty acids and coenzyme A in a one-to-one binding mode with high specificity and affinity. Acyl-CoAs are important intermediates in fatty lipid synthesis and fatty acid degradation and play a...; Region: ACBP; cl00221 441952000938 acyl-CoA binding pocket [chemical binding]; other site 441952000939 CoA binding site [chemical binding]; other site 441952000940 3-hydroxyacyl-CoA dehydrogenase [Lipid metabolism]; Region: FadB; COG1250 441952000941 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 441952000942 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 441952000943 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 441952000944 substrate binding site [chemical binding]; other site 441952000945 oxyanion hole (OAH) forming residues; other site 441952000946 trimer interface [polypeptide binding]; other site 441952000947 acyl-CoA dehydrogenase; Reviewed; Region: fadE; PRK09463 441952000948 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 441952000949 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 441952000950 active site 441952000951 Domain of unknown function (DUF1974); Region: DUF1974; pfam09317 441952000952 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK08974 441952000953 AMP-binding enzyme; Region: AMP-binding; cl15778 441952000954 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 441952000955 Arsenate Reductase (ArsC) family, ArsC subfamily; arsenic reductases similar to that encoded by arsC on the R733 plasmid of Escherichia coli. E. coli ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], the first step in the...; Region: ArsC_ArsC; cd03034 441952000956 ArsC family; Region: ArsC; pfam03960 441952000957 catalytic residues [active] 441952000958 Monomeric isocitrate dehydrogenase; Region: IDH; cl15383 441952000959 DEAD-like helicases superfamily; Region: DEXDc; smart00487 441952000960 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 441952000961 ATP binding site [chemical binding]; other site 441952000962 putative Mg++ binding site [ion binding]; other site 441952000963 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 441952000964 nucleotide binding region [chemical binding]; other site 441952000965 ATP-binding site [chemical binding]; other site 441952000966 Helicase associated domain (HA2); Region: HA2; cl04503 441952000967 Oligonucleotide/oligosaccharide-binding (OB)-fold; Region: OB_NTP_bind; pfam07717 441952000968 Domain of unknown function (DUF3418); Region: DUF3418; pfam11898 441952000969 Domain of unknown function (DUF3418); Region: DUF3418; pfam11898 441952000970 L,D-transpeptidase catalytic domain; Region: YkuD; cl15405 441952000971 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 441952000972 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 441952000973 DNA binding site [nucleotide binding] 441952000974 active site 441952000975 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 441952000976 mercuric reductase; Validated; Region: PRK06370 441952000977 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 441952000978 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 441952000979 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 441952000980 curved DNA-binding protein CbpA; Provisional; Region: PRK10266 441952000981 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 441952000982 HSP70 interaction site [polypeptide binding]; other site 441952000983 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 441952000984 substrate binding site [polypeptide binding]; other site 441952000985 dimer interface [polypeptide binding]; other site 441952000986 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 441952000987 EamA-like transporter family; Region: EamA; cl01037 441952000988 Phosphoinositide 3-kinase family, accessory domain (PIK domain); PIK domain is conserved in PI3 and PI4-kinases. Its role is unclear, but it has been suggested to be involved in substrate presentation. Phosphoinositide 3-kinases play an important role in...; Region: PI3Ka; cl00271 441952000989 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 441952000990 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 441952000991 synthetase active site [active] 441952000992 NTP binding site [chemical binding]; other site 441952000993 metal binding site [ion binding]; metal-binding site 441952000994 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 441952000995 Domain of unknown function (DUF4124); Region: DUF4124; pfam13511 441952000996 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 441952000997 S-adenosylmethionine binding site [chemical binding]; other site 441952000998 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 441952000999 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 441952001000 DNA binding site [nucleotide binding] 441952001001 Int/Topo IB signature motif; other site 441952001002 active site 441952001003 Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814 441952001004 Transmembrane amino acid transporter protein; Region: Aa_trans; cl15776 441952001005 Preprotein translocase subunit SecB. SecB is a cytoplasmic component of the multisubunit membrane-bound enzyme termed Sec protein translocase, which is the main constituent of the General Secretory (type II) Pathway involved in translocation of nascent...; Region: Translocase_SecB; cl00251 441952001006 SecA binding site; other site 441952001007 Preprotein binding site; other site 441952001008 DNA mismatch repair protein MutS; Provisional; Region: PRK05399 441952001009 MutS domain I; Region: MutS_I; pfam01624 441952001010 MutS family domain IV; Region: MutS_IV; pfam05190 441952001011 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 441952001012 Walker A/P-loop; other site 441952001013 ATP binding site [chemical binding]; other site 441952001014 Q-loop/lid; other site 441952001015 ABC transporter signature motif; other site 441952001016 Walker B; other site 441952001017 D-loop; other site 441952001018 H-loop/switch region; other site 441952001019 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl15772 441952001020 acetyl-CoA carboxylase carboxyltransferase alpha subunit; Provisional; Region: accA; CHL00198 441952001021 N-acetylmuramic acid-6-phosphate etherase; Reviewed; Region: murQ; PRK05441 441952001022 N-acetylmuramic acid 6-phosphate etherase. Members of this family contain the SIS (Sugar ISomerase) domain. The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. The bacterial cell wall sugar N-acetylmuramic acid...; Region: SIS_Etherase; cd05007 441952001023 putative active site [active] 441952001024 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 441952001025 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 441952001026 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 441952001027 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 441952001028 active site 441952001029 HIGH motif; other site 441952001030 dimer interface [polypeptide binding]; other site 441952001031 KMSKS motif; other site 441952001032 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 441952001033 dephospho-CoA kinase; Region: TIGR00152 441952001034 CoA-binding site [chemical binding]; other site 441952001035 ATP-binding [chemical binding]; other site 441952001036 Uncharacterized conserved protein [Function unknown]; Region: COG1565 441952001037 Putative S-adenosyl-L-methionine-dependent methyltransferase; Region: Methyltransf_28; pfam02636 441952001038 pyruvate dehydrogenase subunit E1; Reviewed; Region: aceE; PRK09405 441952001039 Thiamine pyrophosphate (TPP) family, E1 of E. coli PDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the Escherichia coli pyruvate dehydrogenase multienzyme complex (PDC). PDC catalyzes the oxidative...; Region: TPP_E1_EcPDC_like; cd02017 441952001040 dimer interface [polypeptide binding]; other site 441952001041 TPP-binding site [chemical binding]; other site 441952001042 dihydrolipoamide acetyltransferase; Reviewed; Region: PRK11855 441952001043 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 441952001044 E3 interaction surface; other site 441952001045 lipoyl attachment site [posttranslational modification]; other site 441952001046 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 441952001047 E3 interaction surface; other site 441952001048 lipoyl attachment site [posttranslational modification]; other site 441952001049 e3 binding domain; Region: E3_binding; pfam02817 441952001050 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; cl02008 441952001051 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06467 441952001052 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 441952001053 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 441952001054 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 441952001055 Hydrolase of X-linked nucleoside diphosphate N terminal; Region: Nudix_N; pfam12535 441952001056 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_14; cd04672 441952001057 nudix motif; other site 441952001058 Arsenate Reductase (ArsC) family; composed of TRX-fold arsenic reductases and similar proteins including the transcriptional regulator, Spx. ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], using reducing equivalents derived from...; Region: ArsC_family; cd02977 441952001059 ArsC family; Region: ArsC; pfam03960 441952001060 catalytic residue [active] 441952001061 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 441952001062 aspartate 4-decarboxylase; Region: asp_4_decarbox; TIGR03801 441952001063 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 441952001064 pyridoxal 5'-phosphate binding site [chemical binding]; other site 441952001065 homodimer interface [polypeptide binding]; other site 441952001066 catalytic residue [active] 441952001067 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 441952001068 ligand binding site [chemical binding]; other site 441952001069 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; cl11587 441952001070 LytB protein; Region: LYTB; cl00507 441952001071 (E)-4-hydroxy-3-methyl-but-2-enyl pyrophosphate reductase (IPP and DMAPP forming); Region: ispH_lytB; TIGR00216 441952001072 Chorismate mutase (AroH) is one of at least five chorismate-utilizing enzymes present in microorganisms that catalyze the rearrangement of chorismate to prephenic acid, the first committed step in the biosynthesis of aromatic amino acids. In prokaryotes; Region: AroH; cd02185 441952001073 homotrimer interaction site [polypeptide binding]; other site 441952001074 active site 441952001075 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 441952001076 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 441952001077 Biopolymer transport protein ExbD/TolR; Region: ExbD; cl00537 441952001078 TolA protein; Region: tolA_full; TIGR02794 441952001079 tol-pal system beta propeller repeat protein TolB; Region: propeller_TolB; TIGR02800 441952001080 TolB amino-terminal domain; Region: TolB_N; cl00639 441952001081 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 441952001082 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 441952001083 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 441952001084 ligand binding site [chemical binding]; other site 441952001085 short chain dehydrogenase; Provisional; Region: PRK06924 441952001086 carbonyl reductase sniffer-like, classical (c) SDRs; Region: carb_red_sniffer_like_SDR_c; cd05325 441952001087 NADP binding site [chemical binding]; other site 441952001088 homodimer interface [polypeptide binding]; other site 441952001089 active site 441952001090 Protein of unknown function (DUF2805); Region: DUF2805; cl11923 441952001091 Deoxyribodipyrimidine photolyase [DNA replication, recombination, and repair]; Region: PhrB; COG0415 441952001092 DNA photolyase; Region: DNA_photolyase; pfam00875 441952001093 FAD binding domain of DNA photolyase; Region: FAD_binding_7; pfam03441 441952001094 Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385 441952001095 Membrane transport protein; Region: Mem_trans; cl09117 441952001096 Predicted permeases [General function prediction only]; Region: COG0730; cl00498 441952001097 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 441952001098 Transglutaminase-like superfamily; Region: Transglut_core; cl10469 441952001099 Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055 441952001100 Putative anion permease YbiR. Based on sequence similarity, YbiR proteins are predicted to function as anion translocating permeases in eubacteria, archaea and plants. They belong to ArsB/NhaD superfamily of permeases that have been shown to translocate...; Region: YbiR_permease; cd01117 441952001101 transmembrane helices; other site 441952001102 Protein of unknown function (DUF423); Region: DUF423; cl01008 441952001103 Protein of unknown function, DUF393; Region: DUF393; cl01136 441952001104 UbiA prenyltransferase family; Region: UbiA; cl00337 441952001105 UTRA domain; Region: UTRA; cl01230 441952001106 ribonuclease PH; Reviewed; Region: rph; PRK00173 441952001107 Ribonuclease PH; Region: RNase_PH_bact; cd11362 441952001108 hexamer interface [polypeptide binding]; other site 441952001109 active site 441952001110 Peptidase family M48; Region: Peptidase_M48; cl12018 441952001111 LemA family; Region: LemA; cl00742 441952001112 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 441952001113 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 441952001114 dimerization interface [polypeptide binding]; other site 441952001115 putative DNA binding site [nucleotide binding]; other site 441952001116 putative Zn2+ binding site [ion binding]; other site 441952001117 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 441952001118 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 441952001119 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 441952001120 Colicin V production protein; Region: Colicin_V; cl00567 441952001121 DNA repair protein RadA; Provisional; Region: PRK11823 441952001122 Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121 441952001123 Walker A motif/ATP binding site; other site 441952001124 ATP binding site [chemical binding]; other site 441952001125 Walker B motif; other site 441952001126 Subunit ChlI of Mg-chelatase; Region: ChlI; cl12214 441952001127 PilZ domain; Region: PilZ; cl01260 441952001128 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 441952001129 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 441952001130 Tetramer interface [polypeptide binding]; other site 441952001131 active site 441952001132 FMN-binding site [chemical binding]; other site 441952001133 PQ loop repeat; Region: PQ-loop; cl12056 441952001134 PQ loop repeat; Region: PQ-loop; cl12056 441952001135 methionine sulfoxide reductase B; Provisional; Region: PRK00222; cl15841 441952001136 SelR domain; Region: SelR; pfam01641 441952001137 Copper/zinc superoxide dismutase (SOD). superoxide dismutases catalyse the conversion of superoxide radicals to molecular oxygen. Three evolutionarily distinct families of SODs are known, of which the copper/zinc-binding family is one. Defects in the...; Region: Cu-Zn_Superoxide_Dismutase; cd00305 441952001138 E-class dimer interface [polypeptide binding]; other site 441952001139 P-class dimer interface [polypeptide binding]; other site 441952001140 active site 441952001141 Cu2+ binding site [ion binding]; other site 441952001142 Zn2+ binding site [ion binding]; other site 441952001143 Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; cl01132 441952001144 Amino acid transporters [Amino acid transport and metabolism]; Region: LysP; COG0833 441952001145 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 441952001146 S-(hydroxymethyl)glutathione dehydrogenase/class III alcohol dehydrogenase; Region: adh_III_F_hyde; TIGR02818 441952001147 NAD(P) binding site [chemical binding]; other site 441952001148 aspartate aminotransferase; Provisional; Region: PRK07568 441952001149 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 441952001150 pyridoxal 5'-phosphate binding site [chemical binding]; other site 441952001151 homodimer interface [polypeptide binding]; other site 441952001152 catalytic residue [active] 441952001153 Cation efflux family; Region: Cation_efflux; cl00316 441952001154 recombination and repair protein; Provisional; Region: PRK10869 441952001155 RecN ATPase involved in DNA repair; ABC (ATP-binding cassette) transporter nucleotide-binding domain; ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds including sugars, ions, peptides, and...; Region: ABC_RecN; cd03241 441952001156 Walker A/P-loop; other site 441952001157 ATP binding site [chemical binding]; other site 441952001158 Q-loop/lid; other site 441952001159 RecN ATPase involved in DNA repair; ABC (ATP-binding cassette) transporter nucleotide-binding domain; ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds including sugars, ions, peptides, and...; Region: ABC_RecN; cd03241 441952001160 ABC transporter signature motif; other site 441952001161 Walker B; other site 441952001162 D-loop; other site 441952001163 H-loop/switch region; other site 441952001164 Tfp pilus assembly protein, major pilin PilA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilA; COG4969 441952001165 Pilin (bacterial filament); Region: Pilin; pfam00114 441952001166 PAP2_like proteins, Lipid A 1-phosphatase subfamily. Lipid A 1-phosphatase, or LpxE from Francisella novicida selectively dephosphorylates lipid A at the 1-position. Lipid A is the membrane-anchor component of lipopolysaccharides (LPS), the major...; Region: PAP2_lipid_A_1_phosphatase; cd03389 441952001167 active site 441952001168 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14180 441952001169 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 441952001170 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 441952001171 homodimer interface [polypeptide binding]; other site 441952001172 NADP binding site [chemical binding]; other site 441952001173 substrate binding site [chemical binding]; other site 441952001174 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 441952001175 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 441952001176 dimerization interface [polypeptide binding]; other site 441952001177 putative ATP binding site [chemical binding]; other site 441952001178 non-metazoan 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_Sc; cd01414 441952001179 active site 441952001180 ATP binding site [chemical binding]; other site 441952001181 substrate binding site [chemical binding]; other site 441952001182 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 441952001183 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 441952001184 ATP-grasp domain; Region: ATP-grasp_4; cl03087 441952001185 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 441952001186 phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647 441952001187 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 441952001188 active site 441952001189 substrate binding site [chemical binding]; other site 441952001190 cosubstrate binding site; other site 441952001191 catalytic site [active] 441952001192 AIR carboxylase; Region: AIRC; cl00310 441952001193 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 441952001194 ATP-grasp domain; Region: ATP-grasp_4; cl03087 441952001195 Restriction endonuclease; Region: Mrr_cat; cl00516 441952001196 Zn-dependent oligopeptidases [Amino acid transport and metabolism]; Region: Dcp; COG0339 441952001197 Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456 441952001198 active site 441952001199 Zn binding site [ion binding]; other site 441952001200 Mth938-like domain. The members of this family include: Mth938, 2P1, Xcr35, Rpa2829, and several uncharacterized sequences. Mth938 is a hypothetical protein encoded by the Methanobacterium thermoautotrophicum (Mth) genome. This protein crystallizes as a...; Region: Mth938-like; cd00248 441952001201 DNA topoisomerase I; Validated; Region: PRK06599 441952001202 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 441952001203 active site 441952001204 interdomain interaction site; other site 441952001205 putative metal-binding site [ion binding]; other site 441952001206 nucleotide binding site [chemical binding]; other site 441952001207 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 441952001208 domain I; other site 441952001209 DNA binding groove [nucleotide binding] 441952001210 phosphate binding site [ion binding]; other site 441952001211 domain II; other site 441952001212 domain III; other site 441952001213 nucleotide binding site [chemical binding]; other site 441952001214 catalytic site [active] 441952001215 domain IV; other site 441952001216 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 441952001217 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 441952001218 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 441952001219 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 441952001220 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 441952001221 P-loop; other site 441952001222 Magnesium ion binding site [ion binding]; other site 441952001223 ParB-like nuclease domain; Region: ParBc; cl02129 441952001224 KorB domain; Region: KorB; pfam08535 441952001225 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741 441952001226 GMP synthase - Glutamine amidotransferase domain [Nucleotide transport and metabolism]; Region: GuaA; COG0518 441952001227 catalytic triad [active] 441952001228 Fatty acyltransferase-like subfamily of the SGNH hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its...; Region: fatty_acyltransferase_like; cd01846 441952001229 active site 441952001230 catalytic triad [active] 441952001231 oxyanion hole [active] 441952001232 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl15754 441952001233 23S rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: FtsJ; COG0293 441952001234 Signal peptidase (SPase) II; Region: Peptidase_A8; cl00458 441952001235 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743 441952001236 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 441952001237 active site 441952001238 HIGH motif; other site 441952001239 nucleotide binding site [chemical binding]; other site 441952001240 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 441952001241 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 441952001242 active site 441952001243 KMSKS motif; other site 441952001244 Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960 441952001245 tRNA binding surface [nucleotide binding]; other site 441952001246 anticodon binding site; other site 441952001247 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 441952001248 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 441952001249 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 441952001250 active site 441952001251 Riboflavin kinase; Region: Flavokinase; cl03312 441952001252 malate dehydrogenase; Provisional; Region: PRK13529 441952001253 Malic enzyme, N-terminal domain; Region: malic; pfam00390 441952001254 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 441952001255 NAD(P) binding pocket [chemical binding]; other site 441952001256 Protein of unknown function (DUF3573); Region: DUF3573; pfam12097 441952001257 Protein of unknown function (DUF3573); Region: DUF3573; pfam12097 441952001258 GTP-binding protein Der; Reviewed; Region: PRK00093 441952001259 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 441952001260 G1 box; other site 441952001261 GTP/Mg2+ binding site [chemical binding]; other site 441952001262 Switch I region; other site 441952001263 G2 box; other site 441952001264 Switch II region; other site 441952001265 G3 box; other site 441952001266 G4 box; other site 441952001267 G5 box; other site 441952001268 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 441952001269 G1 box; other site 441952001270 GTP/Mg2+ binding site [chemical binding]; other site 441952001271 Switch I region; other site 441952001272 G2 box; other site 441952001273 G3 box; other site 441952001274 Switch II region; other site 441952001275 G4 box; other site 441952001276 G5 box; other site 441952001277 This domain family includes the Enolpyruvate transferase (EPT) family and the RNA 3' phosphate cyclase family (RTPC). These 2 families differ in that EPT is formed by 3 repeats of an alpha-beta structural domain while RTPC has 3 similar repeats with a...; Region: EPT_RTPC-like; cl00288 441952001278 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 441952001279 putative active site [active] 441952001280 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13905 441952001281 FAD binding domain; Region: FAD_binding_4; pfam01565 441952001282 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 441952001283 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 441952001284 biotin biosynthesis protein BioC; Region: BioC; TIGR02072 441952001285 Protein Kinase C Interacting protein related (PKCI): PKCI and related proteins belong to the ubiquitous HIT family of hydrolases that act on alpha-phosphates of ribonucleotides. The members of this subgroup have a conserved HxHxHxx motif (x is a...; Region: PKCI_related; cd01276 441952001286 nucleotide binding site/active site [active] 441952001287 HIT family signature motif; other site 441952001288 catalytic residue [active] 441952001289 Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661 441952001290 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 441952001291 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3165 441952001292 ubiE/COQ5 methyltransferase family; Region: Ubie_methyltran; pfam01209 441952001293 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 441952001294 S-adenosylmethionine binding site [chemical binding]; other site 441952001295 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 441952001296 glucokinase, proteobacterial type; Region: glk; TIGR00749 441952001297 Intracellular septation protein A; Region: IspA; cl01098 441952001298 Telomere recombination; Region: Sua5_yciO_yrdC; cl00305 441952001299 uncharacterized protein, YigZ family; Region: IMPACT_YIGZ; TIGR00257 441952001300 Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205 441952001301 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 441952001302 D-galactonate transporter; Region: 2A0114; TIGR00893 441952001303 putative substrate translocation pore; other site 441952001304 Neurotransmitter-gated ion-channel ligand binding domain; Region: Neur_chan_LBD; pfam02931 441952001305 Uncharacterized homologs of Site-2 protease (S2P), zinc metalloproteases (MEROPS family M50) which cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of the...; Region: S2P-M50_like_1; cd06158 441952001306 active site 441952001307 putative substrate binding region [chemical binding]; other site 441952001308 Phosphatidylserine decarboxylase; Region: PS_Dcarbxylase; cl03656 441952001309 bifunctional nicotinamide mononucleotide adenylyltransferase/ADP-ribose pyrophosphatase; Provisional; Region: PRK05379 441952001310 Nicotinamide/nicotinate mononucleotide adenylyltransferase of bifunctional proteins, also containing a Nudix hydrolase domain; Region: NMNAT_Nudix; cd02168 441952001311 active site 441952001312 (T/H)XGH motif; other site 441952001313 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_15; cd04673 441952001314 nudix motif; other site 441952001315 UDP-N-acetylglucosamine diphosphorylase/glucosamine-1-phosphate N-acetyltransferase; Region: glmU; TIGR01173 441952001316 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 441952001317 Substrate binding site; other site 441952001318 Mg++ binding site; other site 441952001319 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 441952001320 active site 441952001321 substrate binding site [chemical binding]; other site 441952001322 CoA binding site [chemical binding]; other site 441952001323 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 441952001324 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 441952001325 glutaminase active site [active] 441952001326 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 441952001327 dimer interface [polypeptide binding]; other site 441952001328 active site 441952001329 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 441952001330 dimer interface [polypeptide binding]; other site 441952001331 active site 441952001332 Ribosomal protein S21; Region: Ribosomal_S21; cl00529 441952001333 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box protein; Region: CSP_CDS; cd04458 441952001334 DNA-binding site [nucleotide binding]; DNA binding site 441952001335 RNA-binding motif; other site 441952001336 MazG nucleotide pyrophosphohydrolase domain; Region: MazG; cl00345 441952001337 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 441952001338 active site 441952001339 DNA topoisomerase IV subunit A; Validated; Region: PRK05561 441952001340 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes in DNA...; Region: TOP4c; cd00187 441952001341 CAP-like domain; other site 441952001342 active site 441952001343 primary dimer interface [polypeptide binding]; other site 441952001344 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 441952001345 BNR repeat-like domain; Region: BNR_2; pfam13088 441952001346 Sialidases or neuraminidases function to bind and hydrolyze terminal sialic acid residues from various glycoconjugates as well as playing roles in pathogenesis, bacterial nutrition and cellular interactions. They have a six-bladed, beta-propeller fold...; Region: Sialidase; cd00260 441952001347 catalytic site [active] 441952001348 Asp-box motif; other site 441952001349 lytic murein transglycosylase; Provisional; Region: PRK11619 441952001350 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic 'goose-type' lysozymes (GEWL). LTs catalyze...; Region: LT_GEWL; cd00254 441952001351 N-acetyl-D-glucosamine binding site [chemical binding]; other site 441952001352 catalytic residue [active] 441952001353 Predicted membrane protein (DUF2254); Region: DUF2254; pfam10011 441952001354 DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673 441952001355 Bacterial DNA polymerase III alpha subunit; Region: DNA_pol3_alpha; pfam07733 441952001356 Replication protein A, class 2b aminoacyl-tRNA synthetases, and related proteins with oligonucleotide/oligosaccharide (OB) fold; Region: RPA_2b-aaRSs_OBF_like; cl09930 441952001357 generic binding surface II; other site 441952001358 generic binding surface I; other site 441952001359 lipoprotein releasing system, transmembrane protein, LolC/E family; Region: lolCE; TIGR02212 441952001360 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 441952001361 FtsX-like permease family; Region: FtsX; cl15850 441952001362 lipoprotein releasing system, ATP-binding protein; Region: LolD_lipo_ex; TIGR02211 441952001363 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 441952001364 Walker A/P-loop; other site 441952001365 ATP binding site [chemical binding]; other site 441952001366 Q-loop/lid; other site 441952001367 ABC transporter signature motif; other site 441952001368 Walker B; other site 441952001369 D-loop; other site 441952001370 H-loop/switch region; other site 441952001371 glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389 441952001372 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 441952001373 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 441952001374 lipoyl attachment site [posttranslational modification]; other site 441952001375 Glycine cleavage system protein P (pyridoxal-binding), N-terminal domain [Amino acid transport and metabolism]; Region: GcvP; COG0403 441952001376 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 441952001377 tetramer interface [polypeptide binding]; other site 441952001378 pyridoxal 5'-phosphate binding site [chemical binding]; other site 441952001379 catalytic residue [active] 441952001380 Glycine cleavage system protein P (pyridoxal-binding), C-terminal domain [Amino acid transport and metabolism]; Region: GcvP; COG1003 441952001381 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 441952001382 tetramer interface [polypeptide binding]; other site 441952001383 pyridoxal 5'-phosphate binding site [chemical binding]; other site 441952001384 catalytic residue [active] 441952001385 Shikimate 5-dehydrogenase [Amino acid transport and metabolism]; Region: AroE; COG0169 441952001386 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 441952001387 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 441952001388 shikimate binding site; other site 441952001389 NAD(P) binding site [chemical binding]; other site 441952001390 pullulanase, type I; Region: pulA_typeI; TIGR02104 441952001391 Early set domain associated with the catalytic domain of pullulanase (also called dextrinase and alpha-dextrin endo-1,6-alpha glucosidase); Region: E_set_Pullulanase; cd02860 441952001392 Alpha amylase catalytic domain found in Pullulanase (also called dextrinase; alpha-dextrin endo-1,6-alpha glucosidase), limit dextrinase, and related proteins; Region: AmyAc_Pullulanase_LD-like; cd11341 441952001393 Ca binding site [ion binding]; other site 441952001394 active site 441952001395 catalytic site [active] 441952001396 glycogen branching enzyme; Provisional; Region: PRK12313 441952001397 N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855 441952001398 Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322 441952001399 active site 441952001400 catalytic site [active] 441952001401 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; cl02706 441952001402 phosphoglucomutase; Region: PLN02307 441952001403 Phosphoglucomutase 1 (PGM1) catalyzes the bidirectional interconversion of glucose-1-phosphate (G-1-P) and glucose-6-phosphate (G-6-P) via a glucose 1,6-diphosphate intermediate, an important metabolic step in prokaryotes and eukaryotes. In one direction; Region: PGM1; cd03085 441952001404 substrate binding site [chemical binding]; other site 441952001405 dimer interface [polypeptide binding]; other site 441952001406 active site 441952001407 metal binding site [ion binding]; metal-binding site 441952001408 glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK00725 441952001409 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 441952001410 ligand binding site; other site 441952001411 oligomer interface; other site 441952001412 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 441952001413 dimer interface [polypeptide binding]; other site 441952001414 N-terminal domain interface [polypeptide binding]; other site 441952001415 sulfate 1 binding site; other site 441952001416 glycogen synthase; Provisional; Region: glgA; PRK00654 441952001417 This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791 441952001418 ADP-binding pocket [chemical binding]; other site 441952001419 homodimer interface [polypeptide binding]; other site 441952001420 This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300 441952001421 homodimer interface [polypeptide binding]; other site 441952001422 glycogen/starch/alpha-glucan phosphorylases; Region: P_ylase; TIGR02093 441952001423 active site pocket [active] 441952001424 4-alpha-glucanotransferase; Region: Glyco_hydro_77; cl00711 441952001425 Class II Glycyl-tRNA synthetase (GlyRS) alpha subunit core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes and in arabidopsis. It is responsible for the...; Region: GlyRS_alpha_core; cd00733 441952001426 dimer interface [polypeptide binding]; other site 441952001427 motif 1; other site 441952001428 active site 441952001429 motif 2; other site 441952001430 motif 3; other site 441952001431 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 441952001432 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 441952001433 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 441952001434 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 441952001435 Domain of unknown function (DUF4156); Region: DUF4156; pfam13698 441952001436 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 441952001437 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase; Region: murF; TIGR01143 441952001438 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 441952001439 bifunctional aspartokinase I/homoserine dehydrogenase I; Provisional; Region: thrA; PRK09436 441952001440 Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452 441952001441 nucleotide binding site [chemical binding]; other site 441952001442 substrate binding site [chemical binding]; other site 441952001443 ACT domains of the bifunctional enzyme aspartokinase (AK) - homoserine dehydrogenase (HSDH); Region: ACT_AKi-HSDH-ThrA-like_1; cd04921 441952001444 dimer interface [polypeptide binding]; other site 441952001445 putative threonine allosteric regulatory site; other site 441952001446 ACT domains C-terminal to the catalytic domain of aspartokinase (AK; 4-L-aspartate-4-phosphotransferase); Region: ACT_AK-like_2; cd04892 441952001447 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 441952001448 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 441952001449 homoserine kinase; Provisional; Region: PRK01212 441952001450 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 441952001451 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 441952001452 S-adenosylmethionine decarboxylase; Region: AdoMet_dc; cl00687 441952001453 spermidine synthase; Provisional; Region: PRK00811 441952001454 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 441952001455 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Arginine Decarboxylase; Region: PLPDE_III_ADC; cd06830 441952001456 dimer interface [polypeptide binding]; other site 441952001457 active site 441952001458 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 441952001459 catalytic residues [active] 441952001460 substrate binding site [chemical binding]; other site 441952001461 N-carbamolyputrescine amidase; Region: PLN02747 441952001462 N-carbamoylputrescine amidohydrolase (CPA) (class 11 nitrilases); Region: CPA; cd07573 441952001463 putative active site; other site 441952001464 catalytic triad [active] 441952001465 putative dimer interface [polypeptide binding]; other site 441952001466 Escherichia coli YbbF/LpxH and related proteins, metallophosphatase domain; Region: MPP_YbbF-LpxH; cd07398 441952001467 putative active site [active] 441952001468 putative metal binding site [ion binding]; other site 441952001469 orotate phosphoribosyltransferase; Validated; Region: pyrE; PRK00455 441952001470 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 441952001471 active site 441952001472 UDP-N-acetylmuramate:L-alanyl-gamma-D-glutamyl- meso-diaminopimelate ligase; Region: mpl; TIGR01081 441952001473 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 441952001474 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 441952001475 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 441952001476 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 441952001477 dimerization interface [polypeptide binding]; other site 441952001478 putative DNA binding site [nucleotide binding]; other site 441952001479 putative Zn2+ binding site [ion binding]; other site 441952001480 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 441952001481 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_HprK; cl00270 441952001482 Prolyl 4-hydroxylase alpha subunit homologues; Region: P4Hc; smart00702 441952001483 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy; cl15773 441952001484 Flagellin N-methylase; Region: FliB; cl00497 441952001485 RNA binding domain of NusB (N protein-Utilization Substance B) and Sun (also known as RrmB or Fmu) proteins. This family includes two orthologous groups exemplified by the transcription termination factor NusB and the N-terminal domain of the...; Region: NusB_Sun; cl00223 441952001486 putative RNA binding site [nucleotide binding]; other site 441952001487 Predicted amidohydrolase [General function prediction only]; Region: COG0388 441952001488 Xanthomonas campestris XC1258 and related proteins, members of the nitrilase superfamily (putative class 13 nitrilases); Region: Xc-1258_like; cd07575 441952001489 putative active site [active] 441952001490 catalytic triad [active] 441952001491 multimer interface [polypeptide binding]; other site 441952001492 dimer interface [polypeptide binding]; other site 441952001493 Protein of unknown function (DUF3568); Region: DUF3568; pfam12092 441952001494 methionine aminotransferase; Validated; Region: PRK09082 441952001495 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 441952001496 pyridoxal 5'-phosphate binding site [chemical binding]; other site 441952001497 homodimer interface [polypeptide binding]; other site 441952001498 catalytic residue [active] 441952001499 prolyl-tRNA synthetase; Provisional; Region: PRK09194 441952001500 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent formation of...; Region: ProRS_core_prok; cd00779 441952001501 dimer interface [polypeptide binding]; other site 441952001502 motif 1; other site 441952001503 active site 441952001504 motif 2; other site 441952001505 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334 441952001506 putative deacylase active site [active] 441952001507 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it attaches...; Region: class_II_aaRS-like_core; cl00268 441952001508 active site 441952001509 motif 3; other site 441952001510 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 441952001511 anticodon binding site; other site 441952001512 RT_like: Reverse transcriptase (RT, RNA-dependent DNA polymerase)_like family. An RT gene is usually indicative of a mobile element such as a retrotransposon or retrovirus. RTs occur in a variety of mobile elements, including retrotransposons; Region: RT_like; cl02808 441952001513 nucleic acid binding site [nucleotide binding]; other site 441952001514 Disulfide bond formation protein DsbB; Region: DsbB; cl00649 441952001515 Fe-S metabolism associated domain; Region: SufE; cl00951 441952001516 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 441952001517 active site 441952001518 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 441952001519 Sporulation related domain; Region: SPOR; cl10051 441952001520 FeoA domain; Region: FeoA; cl00838 441952001521 SOS-response transcriptional repressors (RecA-mediated autopeptidases) [Transcription / Signal transduction mechanisms]; Region: LexA; COG1974 441952001522 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 441952001523 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 441952001524 Catalytic site [active] 441952001525 EamA-like transporter family; Region: EamA; cl01037 441952001526 Glutamate synthase domain 2 [Amino acid transport and metabolism]; Region: GltB; COG0069 441952001527 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 441952001528 active site 441952001529 FMN binding site [chemical binding]; other site 441952001530 substrate binding site [chemical binding]; other site 441952001531 3Fe-4S cluster binding site [ion binding]; other site 441952001532 Exodeoxyribonuclease V, gamma subunit; Region: Exonuc_V_gamma; pfam04257 441952001533 exonuclease V subunit gamma; Provisional; Region: recC; PRK11069 441952001534 Fusaric acid resistance protein-like; Region: FUSC_2; cl15844 441952001535 Predicted transcriptional regulator containing an HTH domain and an uncharacterized domain shared with the mammalian protein Schlafen [Transcription]; Region: COG2865 441952001536 Divergent AAA domain; Region: AAA_4; pfam04326 441952001537 ATP-dependent DNA helicase recG C-terminal; Region: HATPase_c_4; pfam13749 441952001538 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 441952001539 putative DNA binding site [nucleotide binding]; other site 441952001540 putative Zn2+ binding site [ion binding]; other site 441952001541 exodeoxyribonuclease V, beta subunit; Region: recB; TIGR00609 441952001542 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641 441952001543 exodeoxyribonuclease V, alpha subunit; Region: recD; TIGR01447 441952001544 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 441952001545 Family description; Region: UvrD_C_2; cl15862 441952001546 Type III pantothenate kinase; Region: Pan_kinase; cl09130 441952001547 Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919 441952001548 tetramerization interface [polypeptide binding]; other site 441952001549 active site 441952001550 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 441952001551 pantoate--beta-alanine ligase; Region: panC; TIGR00018 441952001552 active site 441952001553 nucleotide binding site [chemical binding]; other site 441952001554 HIGH motif; other site 441952001555 KMSKS motif; other site 441952001556 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 441952001557 active site 441952001558 oligomerization interface [polypeptide binding]; other site 441952001559 metal binding site [ion binding]; metal-binding site 441952001560 Domain of unknown function (DUF2520); Region: DUF2520; pfam10728 441952001561 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 441952001562 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 441952001563 nucleotide binding pocket [chemical binding]; other site 441952001564 K-X-D-G motif; other site 441952001565 catalytic site [active] 441952001566 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 441952001567 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 441952001568 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 441952001569 Dimer interface [polypeptide binding]; other site 441952001570 BRCT sequence motif; other site 441952001571 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 441952001572 16S rRNA methyltransferase B; Provisional; Region: PRK10901 441952001573 RNA binding domain of NusB (N protein-Utilization Substance B) and Sun (also known as RrmB or Fmu) proteins. This family includes two orthologous groups exemplified by the transcription termination factor NusB and the N-terminal domain of the...; Region: NusB_Sun; cl00223 441952001574 putative RNA binding site [nucleotide binding]; other site 441952001575 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl15754 441952001576 IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639 441952001577 active site 441952001578 dimerization interface [polypeptide binding]; other site 441952001579 putative transporter; Provisional; Region: PRK03699 441952001580 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl15754 441952001581 YCII-related domain; Region: YCII; cl00999 441952001582 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 441952001583 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 441952001584 dimer interface [polypeptide binding]; other site 441952001585 active site 441952001586 Phosphopantetheine attachment site; Region: PP-binding; cl09936 441952001587 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 441952001588 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 441952001589 NAD(P) binding site [chemical binding]; other site 441952001590 homotetramer interface [polypeptide binding]; other site 441952001591 homodimer interface [polypeptide binding]; other site 441952001592 active site 441952001593 Acyl transferase domain; Region: Acyl_transf_1; cl08282 441952001594 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 441952001595 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 441952001596 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 441952001597 dimer interface [polypeptide binding]; other site 441952001598 active site 441952001599 CoA binding pocket [chemical binding]; other site 441952001600 Phosphate acetyl/butaryl transferase; Region: PTA_PTB; cl00390 441952001601 Ribosomal L32p protein family; Region: Ribosomal_L32p; cl09115 441952001602 Uncharacterized ACR, COG1399; Region: DUF177; cl00616 441952001603 transketolase; Reviewed; Region: PRK05899 441952001604 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 441952001605 TPP-binding site [chemical binding]; other site 441952001606 dimer interface [polypeptide binding]; other site 441952001607 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 441952001608 PYR/PP interface [polypeptide binding]; other site 441952001609 dimer interface [polypeptide binding]; other site 441952001610 TPP binding site [chemical binding]; other site 441952001611 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 441952001612 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 441952001613 glyceraldehyde-3-phosphate dehydrogenase, type I; Region: GAPDH-I; TIGR01534 441952001614 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; cl15856 441952001615 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 441952001616 Phosphoglycerate kinase; Region: PGK; pfam00162 441952001617 substrate binding site [chemical binding]; other site 441952001618 hinge regions; other site 441952001619 ADP binding site [chemical binding]; other site 441952001620 catalytic site [active] 441952001621 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl09155 441952001622 pyruvate kinase; Provisional; Region: PRK05826 441952001623 domain interfaces; other site 441952001624 active site 441952001625 hypothetical protein; Provisional; Region: PRK08185 441952001626 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 441952001627 intersubunit interface [polypeptide binding]; other site 441952001628 active site 441952001629 zinc binding site [ion binding]; other site 441952001630 Na+ binding site [ion binding]; other site 441952001631 putrescine transporter ATP-binding subunit; Provisional; Region: potG; PRK11607 441952001632 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 441952001633 Walker A/P-loop; other site 441952001634 ATP binding site [chemical binding]; other site 441952001635 Q-loop/lid; other site 441952001636 ABC transporter signature motif; other site 441952001637 Walker B; other site 441952001638 D-loop; other site 441952001639 H-loop/switch region; other site 441952001640 TOBE domain; Region: TOBE_2; cl01440 441952001641 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 441952001642 dimer interface [polypeptide binding]; other site 441952001643 conserved gate region; other site 441952001644 putative PBP binding loops; other site 441952001645 ABC-ATPase subunit interface; other site 441952001646 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 441952001647 dimer interface [polypeptide binding]; other site 441952001648 conserved gate region; other site 441952001649 putative PBP binding loops; other site 441952001650 ABC-ATPase subunit interface; other site 441952001651 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 441952001652 hinge; other site 441952001653 3-phosphoshikimate 1-carboxyvinyltransferase; Region: aroA; TIGR01356 441952001654 active site 441952001655 RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278 441952001656 RNA/DNA hybrid binding site [nucleotide binding]; other site 441952001657 active site 441952001658 Type I (cytosolic) bacterial L-asparaginase; Region: L-asparaginase_I; cd08963 441952001659 active site 441952001660 homodimer interface [polypeptide binding]; other site 441952001661 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeA; cd00883 441952001662 active site clefts [active] 441952001663 zinc binding site [ion binding]; other site 441952001664 dimer interface [polypeptide binding]; other site 441952001665 1-aminocyclopropane-1-carboxylate deaminase [Amino acid transport and metabolism]; Region: Acd; COG2515 441952001666 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342 441952001667 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 441952001668 catalytic residue [active] 441952001669 Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730 441952001670 Rubredoxin; Region: Rubredoxin; pfam00301 441952001671 iron binding site [ion binding]; other site 441952001672 Uncharacterized conserved protein [Function unknown]; Region: COG0397; cl00428 441952001673 Uncharacterized ACR, YdiU/UPF0061 family; Region: UPF0061; pfam02696 441952001674 Sodium:dicarboxylate symporter family; Region: SDF; cl00573 441952001675 Predicted phosphosugar isomerases [Cell envelope biogenesis, outer membrane]; Region: AgaS; COG2222 441952001676 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 441952001677 dimer interface [polypeptide binding]; other site 441952001678 active site 441952001679 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 441952001680 dimer interface [polypeptide binding]; other site 441952001681 active site 441952001682 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 441952001683 Sugar (and other) transporter; Region: Sugar_tr; pfam00083 441952001684 putative substrate translocation pore; other site 441952001685 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 441952001686 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 441952001687 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366 441952001688 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 441952001689 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 441952001690 Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496 441952001691 Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; cl00650 441952001692 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 441952001693 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 441952001694 X-Prolyl Aminopeptidase 2. E.C. 3.4.11.9. Also known as X-Pro aminopeptidase, proline aminopeptidase, aminopeptidase P, and aminoacylproline aminopeptidase. Catalyses release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP; cd01085 441952001695 active site 441952001696 DNA/RNA non-specific endonuclease; prokaryotic and eukaryotic double- and single-stranded DNA and RNA endonucleases also present in phosphodiesterases. They exists as monomers and homodimers; Region: NUC; cd00091 441952001697 DNA/RNA non-specific endonuclease; Region: Endonuclease_NS; smart00892 441952001698 active site 441952001699 substrate binding site [chemical binding]; other site 441952001700 Mg2+ binding site [ion binding]; other site 441952001701 beta-lactamase TEM; Provisional; Region: PRK15442 441952001702 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 441952001703 VirK protein; Region: VirK; pfam06903 441952001704 apolipoprotein N-acyltransferase; Reviewed; Region: lnt; PRK00302 441952001705 Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571 441952001706 putative active site [active] 441952001707 catalytic triad [active] 441952001708 putative dimer interface [polypeptide binding]; other site 441952001709 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 441952001710 Transporter associated domain; Region: CorC_HlyC; cl08393 441952001711 Uncharacterized protein family UPF0054; Region: UPF0054; cl00402 441952001712 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 441952001713 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 441952001714 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14325 441952001715 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 441952001716 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 441952001717 FeS/SAM binding site; other site 441952001718 TRAM domain; Region: TRAM; cl01282 441952001719 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 441952001720 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 441952001721 thymidine kinase; Provisional; Region: PRK04296 441952001722 trigger factor; Provisional; Region: tig; PRK01490 441952001723 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; cl11587 441952001724 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 441952001725 Clp protease; Region: CLP_protease; pfam00574 441952001726 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 441952001727 oligomer interface [polypeptide binding]; other site 441952001728 active site residues [active] 441952001729 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 441952001730 ClpX C4-type zinc finger; Region: zf-C4_ClpX; cl05964 441952001731 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 441952001732 Walker A motif; other site 441952001733 ATP binding site [chemical binding]; other site 441952001734 Walker B motif; other site 441952001735 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; cl11083 441952001736 ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466 441952001737 Found in ATP-dependent protease La (LON); Region: LON; smart00464 441952001738 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 441952001739 Walker A motif; other site 441952001740 ATP binding site [chemical binding]; other site 441952001741 Walker B motif; other site 441952001742 arginine finger; other site 441952001743 Subunit ChlI of Mg-chelatase; Region: ChlI; cl12214 441952001744 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 441952001745 IHF dimer interface [polypeptide binding]; other site 441952001746 IHF - DNA interface [nucleotide binding]; other site 441952001747 SurA N-terminal domain; Region: SurA_N_3; cl07813 441952001748 PPIC-type PPIASE domain; Region: Rotamase; cl08278 441952001749 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 441952001750 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 441952001751 Hfq, an abundant, ubiquitous RNA-binding protein, functions as a pleiotrophic regulator of RNA metabolism in prokaryotes, required for transcription of some transcripts and degradation of others. Hfq binds small RNA molecules called riboregulators that...; Region: Hfq; cd01716 441952001752 Sm1 motif; other site 441952001753 intra - hexamer interaction site; other site 441952001754 inter - hexamer interaction site [polypeptide binding]; other site 441952001755 nucleotide binding pocket [chemical binding]; other site 441952001756 Sm2 motif; other site 441952001757 GTP-binding protein HflX; Region: GTP_HflX; TIGR03156 441952001758 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 441952001759 HflX GTPase family; Region: HflX; cd01878 441952001760 G1 box; other site 441952001761 GTP/Mg2+ binding site [chemical binding]; other site 441952001762 Switch I region; other site 441952001763 G2 box; other site 441952001764 G3 box; other site 441952001765 Switch II region; other site 441952001766 G4 box; other site 441952001767 G5 box; other site 441952001768 hypothetical protein; Provisional; Region: PRK07588 441952001769 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 441952001770 Band_7_HflK: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfK (High frequency of lysogenization K). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflK; cd03404 441952001771 HflK protein; Region: hflK; TIGR01933 441952001772 FtsH protease regulator HflC; Provisional; Region: PRK11029 441952001773 Band_7_HflC: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfC (High frequency of lysogenization C). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflC; cd03405 441952001774 Low molecular weight phosphatase family; Region: LMWPc; cd00115 441952001775 Low molecular weight phosphotyrosine protein phosphatase; Region: LMWPc; pfam01451 441952001776 active site 441952001777 Predicted GTPase [General function prediction only]; Region: COG0218 441952001778 YihA (EngB) GTPase family; Region: YihA_EngB; cd01876 441952001779 G1 box; other site 441952001780 GTP/Mg2+ binding site [chemical binding]; other site 441952001781 Switch I region; other site 441952001782 G2 box; other site 441952001783 G3 box; other site 441952001784 Switch II region; other site 441952001785 G4 box; other site 441952001786 G5 box; other site 441952001787 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 441952001788 Ligand Binding Site [chemical binding]; other site 441952001789 B3/4 domain; Region: B3_4; cl11458 441952001790 D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK11790 441952001791 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 441952001792 C-terminal ACT (regulatory) domain of D-3-Phosphoglycerate Dehydrogenase (3PGDH) found in fungi and bacteria; Region: ACT_3PGDH; cd04901 441952001793 L-serine binding site [chemical binding]; other site 441952001794 ACT domain interface; other site 441952001795 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 441952001796 dimerization interface [polypeptide binding]; other site 441952001797 active site 441952001798 Prolipoprotein diacylglyceryl transferase; Region: LGT; cl00478 441952001799 ribonuclease E; Reviewed; Region: rne; PRK10811 441952001800 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 441952001801 homodimer interface [polypeptide binding]; other site 441952001802 oligonucleotide binding site [chemical binding]; other site 441952001803 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 441952001804 cysteine desulfurase DndA; Region: DNA_S_dndA; TIGR03235 441952001805 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 441952001806 catalytic residue [active] 441952001807 DNA repair protein RecO; Reviewed; Region: recO; PRK00085 441952001808 Recombination protein O N terminal; Region: RecO_N; cl15812 441952001809 Recombination protein O C terminal; Region: RecO_C; pfam02565 441952001810 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 441952001811 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 441952001812 BolA-like protein; Region: BolA; cl00386 441952001813 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; cl00360 441952001814 Uncharacterized protein family (UPF0149); Region: UPF0149; cl01173 441952001815 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 441952001816 Ubiquinone biosynthesis hydroxylase, UbiH/UbiF/VisC/COQ6 family; Region: Ubi-OHases; TIGR01988 441952001817 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 441952001818 Ubiquinone biosynthesis hydroxylase, UbiH/UbiF/VisC/COQ6 family; Region: Ubi-OHases; TIGR01988 441952001819 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147 441952001820 Queuosine biosynthesis protein; Region: Queuosine_synth; cl00523 441952001821 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 441952001822 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 441952001823 active site 441952001824 motif I; other site 441952001825 motif II; other site 441952001826 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 441952001827 Uncharacterized ACR, YhhQ family COG1738; Region: DUF165; cl00756 441952001828 Trm112p-like protein; Region: Trm112p; cl01066 441952001829 CMP-KDO synthetase catalyzes the activation of KDO which is an essential component of the lipopolysaccharide; Region: CMP-KDO-Synthetase; cd02517 441952001830 Ligand binding site; other site 441952001831 oligomer interface; other site 441952001832 HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the basis...; Region: HIT_like; cl00228 441952001833 galactokinase; Provisional; Region: PRK05322 441952001834 Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509 441952001835 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 441952001836 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 441952001837 galactose-1-phosphate uridylyltransferase; Provisional; Region: PRK11720 441952001838 Galactose-1-phosphate uridyl transferase (GalT): This enzyme plays a key role in galactose metabolism by catalysing the transfer of a uridine 5'-phosphoryl group from UDP-galactose 1-phosphate. The structure of E.coli GalT reveals that the enzyme...; Region: GalT; cd00608 441952001839 dimer interface [polypeptide binding]; other site 441952001840 active site 441952001841 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 441952001842 Sugar (and other) transporter; Region: Sugar_tr; pfam00083 441952001843 putative substrate translocation pore; other site 441952001844 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 441952001845 Sugar (and other) transporter; Region: Sugar_tr; pfam00083 441952001846 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 441952001847 PPIC-type PPIASE domain; Region: Rotamase; cl08278 441952001848 helicase 45; Provisional; Region: PTZ00424 441952001849 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 441952001850 ATP binding site [chemical binding]; other site 441952001851 Mg++ binding site [ion binding]; other site 441952001852 motif III; other site 441952001853 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 441952001854 nucleotide binding region [chemical binding]; other site 441952001855 ATP-binding site [chemical binding]; other site 441952001856 DbpA RNA binding domain; Region: DbpA; pfam03880 441952001857 Guanylate kinase; Region: Guanylate_kin; pfam00625 441952001858 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 441952001859 catalytic site [active] 441952001860 G-X2-G-X-G-K; other site 441952001861 Quinolinate synthetase A protein; Region: NadA; cl00420 441952001862 quinolinate phosphoribosyltransferase; Validated; Region: PRK09016 441952001863 Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572 441952001864 dimerization interface [polypeptide binding]; other site 441952001865 active site 441952001866 L-aspartate oxidase; Provisional; Region: PRK09077 441952001867 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 441952001868 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 441952001869 Chorismate mutase type II; Region: CM_2; cl00693 441952001870 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 441952001871 catalytic residues [active] 441952001872 dimer interface [polypeptide binding]; other site 441952001873 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 441952001874 YjeF-related protein N-terminus; Region: YjeF_N; cl00318 441952001875 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 441952001876 putative substrate binding site [chemical binding]; other site 441952001877 putative ATP binding site [chemical binding]; other site 441952001878 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 441952001879 RNA binding surface [nucleotide binding]; other site 441952001880 Protein of unknown function (DUF2797); Region: DUF2797; pfam10977 441952001881 Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566 441952001882 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 441952001883 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 441952001884 Transcriptional regulator [Transcription]; Region: IclR; COG1414 441952001885 Helix-turn-helix domains; Region: HTH; cl00088 441952001886 Bacterial transcriptional regulator; Region: IclR; pfam01614 441952001887 Lysine 2,3-aminomutase [Amino acid transport and metabolism]; Region: KamA; COG1509 441952001888 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 441952001889 FeS/SAM binding site; other site 441952001890 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box protein; Region: CSP_CDS; cd04458 441952001891 DNA-binding site [nucleotide binding]; DNA binding site 441952001892 RNA-binding motif; other site 441952001893 Ribosomal protein S21; Region: Ribosomal_S21; cl00529 441952001894 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 441952001895 Cation efflux family; Region: Cation_efflux; cl00316 441952001896 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 441952001897 active site 441952001898 tetramer interface; other site 441952001899 EamA-like transporter family; Region: EamA; cl01037 441952001900 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 441952001901 EamA-like transporter family; Region: EamA; cl01037 441952001902 Protein of unknown function (DUF1311); Region: DUF1311; cl01530 441952001903 recombination protein F; Reviewed; Region: recF; PRK00064 441952001904 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 441952001905 Walker A/P-loop; other site 441952001906 ATP binding site [chemical binding]; other site 441952001907 Q-loop/lid; other site 441952001908 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 441952001909 ABC transporter signature motif; other site 441952001910 Walker B; other site 441952001911 D-loop; other site 441952001912 H-loop/switch region; other site 441952001913 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 441952001914 active site 441952001915 glycyl-tRNA synthetase subunit beta; Validated; Region: glyS; PRK01233 441952001916 RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398 441952001917 tetramer (dimer of dimers) interface [polypeptide binding]; other site 441952001918 active site 441952001919 dimer interface [polypeptide binding]; other site 441952001920 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 441952001921 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 441952001922 GidA associated domain 3; Region: GIDA_assoc_3; pfam13932 441952001923 Fusaric acid resistance protein-like; Region: FUSC_2; cl15844 441952001924 Transcriptional regulator [Transcription]; Region: LysR; COG0583 441952001925 Helix-turn-helix domains; Region: HTH; cl00088 441952001926 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 441952001927 putative effector binding pocket; other site 441952001928 dimerization interface [polypeptide binding]; other site 441952001929 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 441952001930 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 441952001931 NAD(P) binding site [chemical binding]; other site 441952001932 active site 441952001933 N-terminal DEDDh 3'-5' exonuclease domain of Escherichia coli exonuclease I and similar proteins; Region: ExoI_N; cd06138 441952001934 active site 441952001935 substrate binding site [chemical binding]; other site 441952001936 catalytic site [active] 441952001937 Exonuclease C-terminal; Region: Exonuc_X-T_C; pfam08411 441952001938 excinuclease ABC subunit B; Provisional; Region: PRK05298 441952001939 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 441952001940 ATP binding site [chemical binding]; other site 441952001941 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 441952001942 nucleotide binding region [chemical binding]; other site 441952001943 ATP-binding site [chemical binding]; other site 441952001944 Ultra-violet resistance protein B; Region: UvrB; pfam12344 441952001945 UvrB/uvrC motif; Region: UVR; pfam02151 441952001946 Restriction endonuclease; Region: Mrr_cat; cl00516 441952001947 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 441952001948 metabolite-proton symporter; Region: 2A0106; TIGR00883 441952001949 A predicted alpha-helical domain with a conserved ER motif; Region: Alpha-E; cl00980 441952001950 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 441952001951 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 441952001952 generic binding surface II; other site 441952001953 generic binding surface I; other site 441952001954 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 441952001955 SmpB-tmRNA interface; other site 441952001956 Coenzyme Q-binding protein COQ10p and similar proteins; Region: COQ10p_like; cd07813 441952001957 putative coenzyme Q binding site [chemical binding]; other site 441952001958 The TGS domain, named after the ThrRS, GTPase, and SpoT/RelA proteins where it occurs, is structurally similar to ubiquitin. TGS is a small domain of about 50 amino acid residues with a predominantly beta-sheet structure. There is no direct information...; Region: TGS; cl15768 441952001959 bifunctional tRNA (mnm(5)s(2)U34)-methyltransferase/FAD-dependent cmnm(5)s(2)U34 oxidoreductase; Reviewed; Region: mnmC; PRK01747 441952001960 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 441952001961 VacJ like lipoprotein; Region: VacJ; cl01073 441952001962 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; cl08040 441952001963 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019 441952001964 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 441952001965 SAM-dependent methyltransferases [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: SmtA; COG0500 441952001966 S-adenosylmethionine binding site [chemical binding]; other site 441952001967 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 441952001968 GTP-binding protein TypA/BipA; Region: TypA_BipA; TIGR01394 441952001969 G1 box; other site 441952001970 putative GEF interaction site [polypeptide binding]; other site 441952001971 GTP/Mg2+ binding site [chemical binding]; other site 441952001972 Switch I region; other site 441952001973 G2 box; other site 441952001974 G3 box; other site 441952001975 Switch II region; other site 441952001976 G4 box; other site 441952001977 G5 box; other site 441952001978 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 441952001979 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 441952001980 HsdM N-terminal domain; Region: HsdM_N; pfam12161 441952001981 N-6 DNA Methylase; Region: N6_Mtase; pfam02384 441952001982 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 441952001983 Sel1 repeat; Region: Sel1; cl02723 441952001984 ribosome biogenesis GTP-binding protein YlqF; Region: GTPase_YlqF; TIGR03596 441952001985 Circularly permuted YlqF GTPase; Region: YlqF; cd01856 441952001986 GTP/Mg2+ binding site [chemical binding]; other site 441952001987 G4 box; other site 441952001988 G5 box; other site 441952001989 G1 box; other site 441952001990 Switch I region; other site 441952001991 G2 box; other site 441952001992 G3 box; other site 441952001993 Switch II region; other site 441952001994 N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820 441952001995 N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854 441952001996 active site 441952001997 dimer interface [polypeptide binding]; other site 441952001998 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl14000 441952001999 Glutamine amidotransferases class-II (Gn-AT)_YafJ-type. YafJ is a glutamine amidotransferase-like protein of unknown function found in prokaryotes, eukaryotes and archaea. YafJ has a conserved structural fold similar to those of other class II...; Region: YafJ; cd01908 441952002000 putative active site [active] 441952002001 putative dimer interface [polypeptide binding]; other site 441952002002 aspartate aminotransferase; Provisional; Region: PRK05764 441952002003 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 441952002004 pyridoxal 5'-phosphate binding site [chemical binding]; other site 441952002005 homodimer interface [polypeptide binding]; other site 441952002006 catalytic residue [active] 441952002007 GTPase Era; Reviewed; Region: era; PRK00089 441952002008 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 441952002009 G1 box; other site 441952002010 GTP/Mg2+ binding site [chemical binding]; other site 441952002011 Switch I region; other site 441952002012 G2 box; other site 441952002013 Switch II region; other site 441952002014 G3 box; other site 441952002015 G4 box; other site 441952002016 G5 box; other site 441952002017 adenylate kinase; Reviewed; Region: adk; PRK00279 441952002018 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 441952002019 AMP-binding site [chemical binding]; other site 441952002020 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 441952002021 Fimbrial assembly protein (PilN); Region: PilN; pfam05137 441952002022 Pilus assembly protein, PilP; Region: PilP; cl01235 441952002023 type IV pilus secretin (or competence protein) PilQ; Region: IV_pilus_PilQ; TIGR02515 441952002024 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 441952002025 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 441952002026 shikimate kinase; Reviewed; Region: aroK; PRK00131 441952002027 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 441952002028 ADP binding site [chemical binding]; other site 441952002029 magnesium binding site [ion binding]; other site 441952002030 putative shikimate binding site; other site 441952002031 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 441952002032 active site 441952002033 dimer interface [polypeptide binding]; other site 441952002034 metal binding site [ion binding]; metal-binding site 441952002035 Flavinator of succinate dehydrogenase; Region: Sdh5; cl01110 441952002036 bifunctional proline dehydrogenase/pyrroline-5-carboxylate dehydrogenase; Reviewed; Region: PRK11904 441952002037 Proline dehydrogenase; Region: Pro_dh; cl03282 441952002038 Delta(1)-pyrroline-5-carboxylate dehydrogenase, PutA; Region: ALDH_PutA-P5CDH; cd07125 441952002039 Glutamate binding site [chemical binding]; other site 441952002040 NAD binding site [chemical binding]; other site 441952002041 catalytic residues [active] 441952002042 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 441952002043 NAD(P) binding site [chemical binding]; other site 441952002044 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 441952002045 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 441952002046 benzoate transport; Region: 2A0115; TIGR00895 441952002047 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 441952002048 putative substrate translocation pore; other site 441952002049 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 441952002050 Flavoprotein; Region: Flavoprotein; cl08021 441952002051 DNA / pantothenate metabolism flavoprotein; Region: DFP; cl04410 441952002052 ChaB; Region: ChaB; cl01887 441952002053 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 441952002054 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 441952002055 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 441952002056 biotin biosynthesis protein BioC; Region: BioC; TIGR02072 441952002057 7-keto-8-aminopelargonate synthetase and related enzymes [Coenzyme metabolism]; Region: BioF; COG0156 441952002058 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 441952002059 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 441952002060 catalytic residue [active] 441952002061 biotin synthase; Region: bioB; TIGR00433 441952002062 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 441952002063 FeS/SAM binding site; other site 441952002064 Biotin and Thiamin Synthesis associated domain; Region: BATS; cl06149 441952002065 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 441952002066 adenosylmethionine-8-amino-7-oxononanoate transaminase; Region: bioA; TIGR00508 441952002067 inhibitor-cofactor binding pocket; inhibition site 441952002068 pyridoxal 5'-phosphate binding site [chemical binding]; other site 441952002069 catalytic residue [active] 441952002070 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 441952002071 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 441952002072 dimer interface [polypeptide binding]; other site 441952002073 glycine-pyridoxal phosphate binding site [chemical binding]; other site 441952002074 active site 441952002075 folate binding site [chemical binding]; other site 441952002076 Protein of unknown function (DUF615); Region: DUF615; cl01147 441952002077 A4GalT_like proteins catalyze the addition of galactose or glucose residues to the lipooligosaccharide (LOS) or lipopolysaccharide (LPS) of the bacterial cell surface; Region: GT8_A4GalT_like; cd04194 441952002078 Glycosyl transferase family 8; Region: Glyco_transf_8; pfam01501 441952002079 Ligand binding site; other site 441952002080 metal-binding site 441952002081 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 441952002082 Linear amide C-N hydrolases, choloylglycine hydrolase family; Region: CBAH; pfam02275 441952002083 Penicillin V acylase (PVA), also known as conjugated bile salt acid hydrolase (CBAH), catalyzes the hydrolysis of penicillin V to yield 6-amino penicillanic acid (6-APA), an important key intermediate of semisynthetic penicillins. PVA has an N-terminal...; Region: Ntn_PVA; cd00542 441952002084 active site 441952002085 dipeptide/tripeptide permease B; Provisional; Region: PRK10207 441952002086 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 441952002087 putative substrate translocation pore; other site 441952002088 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cl11420 441952002089 Antirestriction protein (ArdA); Region: ArdA; cl01953 441952002090 Domain of unknown function (DUF4391); Region: DUF4391; pfam14335 441952002091 Restriction endonuclease [Defense mechanisms]; Region: COG3587 441952002092 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 441952002093 ATP binding site [chemical binding]; other site 441952002094 putative Mg++ binding site [ion binding]; other site 441952002095 Restriction endonuclease [Defense mechanisms]; Region: COG3587 441952002096 RT_Bac_retron_II: Reverse transcriptases (RTs) in bacterial retrotransposons or retrons. The polymerase reaction of this enzyme leads to the production of a unique RNA-DNA complex called msDNA (multicopy single-stranded (ss)DNA) in which a small ssDNA...; Region: RT_Bac_retron_II; cd03487 441952002097 putative active site [active] 441952002098 putative NTP binding site [chemical binding]; other site 441952002099 putative nucleic acid binding site [nucleotide binding]; other site 441952002100 Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; cl01132 441952002101 23S rRNA m(2)G2445 methyltransferase; Provisional; Region: rlmL; PRK11783 441952002102 THUMP domain; Region: THUMP; cl12076 441952002103 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 441952002104 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 441952002105 S-adenosylmethionine binding site [chemical binding]; other site 441952002106 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 441952002107 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 441952002108 putative active site [active] 441952002109 substrate binding site [chemical binding]; other site 441952002110 putative cosubstrate binding site; other site 441952002111 catalytic site [active] 441952002112 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 441952002113 substrate binding site [chemical binding]; other site 441952002114 glutathione synthetase; Provisional; Region: PRK05246 441952002115 Prokaryotic glutathione synthetase, N-terminal domain; Region: GSH-S_N; pfam02951 441952002116 ATP-grasp domain; Region: ATP-grasp_4; cl03087 441952002117 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062 441952002118 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 441952002119 inhibitor-cofactor binding pocket; inhibition site 441952002120 pyridoxal 5'-phosphate binding site [chemical binding]; other site 441952002121 catalytic residue [active] 441952002122 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971 441952002123 beta-D-glucoside glucohydrolase; Provisional; Region: PRK15098 441952002124 Coproporphyrinogen III oxidase; Region: Coprogen_oxidas; cl00433 441952002125 Ribosomal protein S6; Region: Ribosomal_S6; cl00414 441952002126 Ribosomal protein S18; Region: Ribosomal_S18; cl00373 441952002127 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 441952002128 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 441952002129 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 441952002130 replicative DNA helicase; Region: DnaB; TIGR00665 441952002131 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 441952002132 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 441952002133 Walker A motif; other site 441952002134 ATP binding site [chemical binding]; other site 441952002135 Walker B motif; other site 441952002136 DNA binding loops [nucleotide binding] 441952002137 ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK11194 441952002138 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 441952002139 FeS/SAM binding site; other site 441952002140 type IV pilus biogenesis/stability protein PilW; Region: type_IV_pilW; TIGR02521 441952002141 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 441952002142 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 441952002143 RNA binding surface [nucleotide binding]; other site 441952002144 PseudoU_synth_RluB: Pseudouridine synthase, Escherichia coli RluB like. This group is comprised of bacterial and eukaryotic proteins similar to E. coli RluB. Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to...; Region: PseudoU_synth_RluB; cd02556 441952002145 probable active site [active] 441952002146 preprotein translocase subunit SecA; Validated; Region: secA; CHL00122 441952002147 ribosomal-protein-alanine N-acetyltransferase; Provisional; Region: rimI; PRK09491 441952002148 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 441952002149 PQ loop repeat; Region: PQ-loop; cl12056 441952002150 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 441952002151 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 441952002152 substrate binding pocket [chemical binding]; other site 441952002153 chain length determination region; other site 441952002154 substrate-Mg2+ binding site; other site 441952002155 catalytic residues [active] 441952002156 aspartate-rich region 1; other site 441952002157 active site lid residues [active] 441952002158 aspartate-rich region 2; other site 441952002159 Domain amino terminal to FKBP-type peptidyl-prolyl isomerase; Region: FKBP_N; pfam01346 441952002160 FKBP-type peptidyl-prolyl cis-trans isomerases 1 [Posttranslational modification, protein turnover, chaperones]; Region: FkpA; COG0545 441952002161 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; cl11587 441952002162 tRNA 2-thiocytidine biosynthesis protein TtcA; Provisional; Region: PRK10696 441952002163 This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which binds to Adenosine group. This subfamily; Region: Alpha_ANH_like_II; cd01993 441952002164 Ligand Binding Site [chemical binding]; other site 441952002165 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 441952002166 active site 441952002167 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic 'goose-type' lysozymes (GEWL). LTs catalyze...; Region: LT_GEWL; cd00254 441952002168 N-acetyl-D-glucosamine binding site [chemical binding]; other site 441952002169 catalytic residue [active] 441952002170 D-alanyl-D-alanine carboxypeptidase (penicillin-binding protein 4) [Cell envelope biogenesis, outer membrane]; Region: DacB; COG2027 441952002171 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 441952002172 Ribosomal protein S21; Region: Ribosomal_S21; cl00529 441952002173 GatB domain; Region: GatB_Yqey; cl11497 441952002174 CHC2 zinc finger; Region: zf-CHC2; cl15369 441952002175 DNA primase; Validated; Region: dnaG; PRK05667 441952002176 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 441952002177 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 441952002178 active site 441952002179 metal binding site [ion binding]; metal-binding site 441952002180 interdomain interaction site; other site 441952002181 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 441952002182 RNA polymerase sigma factor RpoD; Validated; Region: PRK05658 441952002183 Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979 441952002184 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 441952002185 Sigma-70, non-essential region; Region: Sigma70_ner; pfam04546 441952002186 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 441952002187 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 441952002188 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 441952002189 DNA binding residues [nucleotide binding] 441952002190 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 441952002191 Protein of unknown function (DUF493); Region: DUF493; cl01102 441952002192 D-alanyl-D-alanine carboxypeptidase; Provisional; Region: dacD; PRK11397 441952002193 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 441952002194 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; cl06814 441952002195 Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412 441952002196 dimer interface [polypeptide binding]; other site 441952002197 substrate binding site [chemical binding]; other site 441952002198 metal binding sites [ion binding]; metal-binding site 441952002199 Low specificity phosphatase (HAD superfamily) [General function prediction only]; Region: COG1778 441952002200 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 441952002201 Lipopolysaccharide-assembly, LptC-related; Region: LptC; pfam06835 441952002202 OstA-like protein; Region: OstA; cl00844 441952002203 ABC-type (unclassified) transport system, ATPase component [General function prediction only]; Region: YhbG; COG1137 441952002204 The ABC transporters belonging to the YhbG family are similar to members of the Mj1267_LivG family, which is involved in the transport of branched-chain amino acids. The genes yhbG and yhbN are located in a single operon and may function together in...; Region: ABC_YhbG; cd03218 441952002205 Walker A/P-loop; other site 441952002206 ATP binding site [chemical binding]; other site 441952002207 Q-loop/lid; other site 441952002208 ABC transporter signature motif; other site 441952002209 Walker B; other site 441952002210 D-loop; other site 441952002211 H-loop/switch region; other site 441952002212 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 441952002213 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 441952002214 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 441952002215 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 441952002216 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 441952002217 PseudoU_synth_EcTruA: Pseudouridine synthase, Escherichia coli TruA like. This group consists of eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA, Pseudomonas aeruginosa truA and human pseudouridine synthase-like 1 (PUSL1); Region: PseudoU_synth_EcTruA; cd02570 441952002218 dimerization interface 3.5A [polypeptide binding]; other site 441952002219 active site 441952002220 Amino acid permease; Region: AA_permease_2; pfam13520 441952002221 GMP synthase; Reviewed; Region: guaA; PRK00074 441952002222 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 441952002223 AMP/PPi binding site [chemical binding]; other site 441952002224 candidate oxyanion hole; other site 441952002225 catalytic triad [active] 441952002226 potential glutamine specificity residues [chemical binding]; other site 441952002227 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 441952002228 ATP Binding subdomain [chemical binding]; other site 441952002229 Ligand Binding sites [chemical binding]; other site 441952002230 Dimerization subdomain; other site 441952002231 1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444 441952002232 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 441952002233 TPP-binding site; other site 441952002234 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 441952002235 PYR/PP interface [polypeptide binding]; other site 441952002236 dimer interface [polypeptide binding]; other site 441952002237 TPP binding site [chemical binding]; other site 441952002238 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 441952002239 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 441952002240 putative active site pocket [active] 441952002241 dimerization interface [polypeptide binding]; other site 441952002242 putative catalytic residue [active] 441952002243 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 441952002244 active site 441952002245 oxyanion hole [active] 441952002246 catalytic triad [active] 441952002247 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 441952002248 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 441952002249 classical (c) SDRs; Region: SDR_c; cd05233 441952002250 NAD(P) binding site [chemical binding]; other site 441952002251 active site 441952002252 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 441952002253 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 441952002254 Walker A motif; other site 441952002255 ATP binding site [chemical binding]; other site 441952002256 Walker B motif; other site 441952002257 arginine finger; other site 441952002258 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 441952002259 lysozyme_like domain. This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222 441952002260 Protein of unknown function (DUF2975); Region: DUF2975; pfam11188 441952002261 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 441952002262 Protein of unknown function (DUF2975); Region: DUF2975; pfam11188 441952002263 Bacterial aspartate proteases, retropepsin-like protease family; Region: retropepsin_like_bacteria; cd05483 441952002264 catalytic motif [active] 441952002265 Catalytic residue [active] 441952002266 Cellular and retroviral pepsin-like aspartate proteases; Region: pepsin_retropepsin_like; cl11403 441952002267 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cl11420 441952002268 EamA-like transporter family; Region: EamA; cl01037 441952002269 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 441952002270 EamA-like transporter family; Region: EamA; cl01037 441952002271 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 441952002272 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 441952002273 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 441952002274 dimer interface [polypeptide binding]; other site 441952002275 motif 1; other site 441952002276 active site 441952002277 motif 2; other site 441952002278 motif 3; other site 441952002279 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 441952002280 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 441952002281 putative tRNA-binding site [nucleotide binding]; other site 441952002282 B3/4 domain; Region: B3_4; cl11458 441952002283 tRNA synthetase B5 domain; Region: B5; cl08394 441952002284 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 441952002285 dimer interface [polypeptide binding]; other site 441952002286 motif 1; other site 441952002287 motif 3; other site 441952002288 motif 2; other site 441952002289 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; cl08386 441952002290 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 441952002291 metal binding site 2 [ion binding]; metal-binding site 441952002292 putative DNA binding helix; other site 441952002293 metal binding site 1 [ion binding]; metal-binding site 441952002294 dimer interface [polypeptide binding]; other site 441952002295 structural Zn2+ binding site [ion binding]; other site 441952002296 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 441952002297 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 441952002298 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; cl08458 441952002299 Predicted divalent heavy-metal cations transporter [Inorganic ion transport and metabolism]; Region: COG0428; cl00437 441952002300 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 441952002301 cardiolipin synthetase; Reviewed; Region: PRK12452 441952002302 Putative catalytic domain, repeat 1, of uncharacterized proteins similar to bacterial cardiolipin synthase; Region: PLDc_CLS_unchar1_1; cd09156 441952002303 putative active site [active] 441952002304 catalytic site [active] 441952002305 Putative catalytic domain, repeat 2, of uncharacterized proteins similar to bacterial cardiolipin synthase; Region: PLDc_CLS_unchar1_2; cd09162 441952002306 putative active site [active] 441952002307 catalytic site [active] 441952002308 cell division ATPase MinD, archaeal; Region: minD_arch; TIGR01969 441952002309 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 441952002310 Walker A motif; other site 441952002311 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 441952002312 trimer interface [polypeptide binding]; other site 441952002313 active site 441952002314 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 441952002315 Mechanosensitive ion channel; Region: MS_channel; pfam00924 441952002316 Lipopolysaccharide-assembly; Region: LptE; cl01125 441952002317 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 441952002318 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 441952002319 HIGH motif; other site 441952002320 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 441952002321 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 441952002322 active site 441952002323 KMSKS motif; other site 441952002324 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 441952002325 tRNA binding surface [nucleotide binding]; other site 441952002326 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 441952002327 Domain of Unknown Function with PDB structure (DUF3857); Region: DUF3857; pfam12969 441952002328 Transglutaminase-like superfamily; Region: Transglut_core; cl10469 441952002329 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD includes...; Region: RuvC_resolvase; cl00243 441952002330 Uncharacterized ACR, COG1678; Region: DUF179; cl00731 441952002331 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 441952002332 PAS fold; Region: PAS_4; pfam08448 441952002333 7-keto-8-aminopelargonate synthetase and related enzymes [Coenzyme metabolism]; Region: BioF; COG0156 441952002334 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 441952002335 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 441952002336 catalytic residue [active] 441952002337 Amino acid transporters [Amino acid transport and metabolism]; Region: LysP; COG0833 441952002338 Helix-turn-helix domains; Region: HTH; cl00088 441952002339 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 441952002340 catalytic residues [active] 441952002341 Uncharacterized protein family (UPF0051); Region: UPF0051; cl03223 441952002342 FeS assembly ATPase SufC; Region: sufC; TIGR01978 441952002343 ABC-type transport system involved in Fe-S cluster assembly, ATPase component. Biosynthesis of iron-sulfur clusters (Fe-S) depends on multiprotein systems. The SUF system of E. coli and Erwinia chrysanthemi is important for Fe-S biogenesis under...; Region: ABC_FeS_Assembly; cd03217 441952002344 Walker A/P-loop; other site 441952002345 ATP binding site [chemical binding]; other site 441952002346 Q-loop/lid; other site 441952002347 ABC transporter signature motif; other site 441952002348 Walker B; other site 441952002349 D-loop; other site 441952002350 H-loop/switch region; other site 441952002351 Uncharacterized protein family (UPF0051); Region: UPF0051; cl03223 441952002352 putative ABC transporter; Region: ycf24; CHL00085 441952002353 FeS assembly SUF system regulator, gammaproteobacterial; Region: suf_reg_Xantho; TIGR02944 441952002354 Helix-turn-helix domains; Region: HTH; cl00088 441952002355 potassium transporter peripheral membrane component; Reviewed; Region: trkA; PRK09496 441952002356 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 441952002357 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 441952002358 putative glutamate/gamma-aminobutyrate antiporter; Region: put_Glu_GABA_T; TIGR03813 441952002359 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 441952002360 rRNA binding site [nucleotide binding]; other site 441952002361 predicted 30S ribosome binding site; other site 441952002362 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 441952002363 Predicted permeases [General function prediction only]; Region: COG0730; cl00498 441952002364 signal recognition particle protein; Provisional; Region: PRK10867 441952002365 SRP54-type protein, helical bundle domain; Region: SRP54_N; cl03758 441952002366 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 441952002367 P loop; other site 441952002368 GTP binding site [chemical binding]; other site 441952002369 Signal peptide binding domain; Region: SRP_SPB; pfam02978 441952002370 NeuB family; Region: NeuB; cl00496 441952002371 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 441952002372 Neisseria meningitides Nape-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: Nape_like_AP-endo; cd10281 441952002373 putative active site [active] 441952002374 putative DNA binding site [nucleotide binding]; other site 441952002375 putative phosphate binding site [ion binding]; other site 441952002376 putative catalytic site [active] 441952002377 metal binding site A [ion binding]; metal-binding site 441952002378 putative AP binding site [nucleotide binding]; other site 441952002379 putative metal binding site B [ion binding]; other site 441952002380 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 441952002381 classical (c) SDRs; Region: SDR_c; cd05233 441952002382 NAD(P) binding site [chemical binding]; other site 441952002383 active site 441952002384 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 441952002385 Predicted kinase [General function prediction only]; Region: COG0645 441952002386 2'-5' RNA ligase superfamily; Region: 2_5_RNA_ligase2; pfam13563 441952002387 glutathione reductase; Validated; Region: PRK06116 441952002388 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 441952002389 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 441952002390 Putative heavy-metal-binding; Region: YbjQ_1; cl00426 441952002391 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cl11420 441952002392 dipeptide/tripeptide permease B; Provisional; Region: PRK10207 441952002393 ATP-dependent RNA helicase SrmB; Provisional; Region: PRK11192 441952002394 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 441952002395 ATP binding site [chemical binding]; other site 441952002396 Mg++ binding site [ion binding]; other site 441952002397 motif III; other site 441952002398 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 441952002399 nucleotide binding region [chemical binding]; other site 441952002400 ATP-binding site [chemical binding]; other site 441952002401 GTP cyclohydrolase I; Provisional; Region: PLN03044 441952002402 Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1), 6-pyrovoyl...; Region: TFold; cl00263 441952002403 active site 441952002404 Predicted amidohydrolase [General function prediction only]; Region: COG0388 441952002405 Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cl11424 441952002406 active site 441952002407 catalytic triad [active] 441952002408 dimer interface [polypeptide binding]; other site 441952002409 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 441952002410 Glutamine amidotransferase class-I; Region: GATase; pfam00117 441952002411 glutamine binding [chemical binding]; other site 441952002412 catalytic triad [active] 441952002413 aminodeoxychorismate synthase; Provisional; Region: PRK07508 441952002414 chorismate binding enzyme; Region: Chorismate_bind; cl10555 441952002415 PyridoxaL 5'-Phosphate Dependent Enzymes class IV (PLPDE_IV). This D-amino acid superfamily, one of five classes of PLPDE, consists of branched-chain amino acid aminotransferases (BCAT), D-amino acid transferases (DAAT), and 4-amino-4-deoxychorismate...; Region: PLPDE_IV; cl00224 441952002416 substrate-cofactor binding pocket; other site 441952002417 pyridoxal 5'-phosphate binding site [chemical binding]; other site 441952002418 catalytic residue [active] 441952002419 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 441952002420 AMP-binding enzyme; Region: AMP-binding; cl15778 441952002421 Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1), 6-pyrovoyl...; Region: TFold; cl00263 441952002422 active site 441952002423 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 441952002424 catalytic center binding site [active] 441952002425 ATP binding site [chemical binding]; other site 441952002426 Pterin binding enzymes. This family includes dihydropteroate synthase (DHPS) and cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). DHPS, a...; Region: Pterin_binding; cl00219 441952002427 dihydropteroate synthase; Region: DHPS; TIGR01496 441952002428 substrate binding pocket [chemical binding]; other site 441952002429 dimer interface [polypeptide binding]; other site 441952002430 inhibitor binding site; inhibition site 441952002431 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 441952002432 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 441952002433 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 441952002434 CoenzymeA binding site [chemical binding]; other site 441952002435 subunit interaction site [polypeptide binding]; other site 441952002436 PHB binding site; other site 441952002437 Glycosyltransferase sugar-binding region containing DXD motif; Region: Gly_transf_sug; pfam04488 441952002438 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 441952002439 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 441952002440 23S rRNA binding site [nucleotide binding]; other site 441952002441 L21 binding site [polypeptide binding]; other site 441952002442 L13 binding site [polypeptide binding]; other site 441952002443 Ribosomal protein L35; Region: Ribosomal_L35p; cl00392 441952002444 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 441952002445 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 441952002446 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 441952002447 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413 441952002448 TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667 441952002449 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; cl08469 441952002450 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 441952002451 active site 441952002452 dimer interface [polypeptide binding]; other site 441952002453 motif 1; other site 441952002454 motif 2; other site 441952002455 motif 3; other site 441952002456 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 441952002457 anticodon binding site; other site 441952002458 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 441952002459 lipoyl attachment site [posttranslational modification]; other site 441952002460 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 441952002461 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 441952002462 homodimer interface [polypeptide binding]; other site 441952002463 active site 441952002464 YbaB/EbfC DNA-binding family; Region: YbaB_DNA_bd; cl00494 441952002465 recombination protein RecR; Provisional; Region: PRK13844 441952002466 RecR protein; Region: RecR; pfam02132 441952002467 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 441952002468 putative active site [active] 441952002469 putative metal-binding site [ion binding]; other site 441952002470 tetramer interface [polypeptide binding]; other site 441952002471 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 441952002472 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 441952002473 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 441952002474 synthetase active site [active] 441952002475 NTP binding site [chemical binding]; other site 441952002476 metal binding site [ion binding]; metal-binding site 441952002477 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 441952002478 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 441952002479 Capsule biosynthesis CapC; Region: Caps_synth_CapC; cl14855 441952002480 poly-gamma-glutamate synthase PgsB/CapB; Region: poly_gGlu_PgsB; TIGR04012 441952002481 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 441952002482 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 441952002483 metabolite-proton symporter; Region: 2A0106; TIGR00883 441952002484 putative substrate translocation pore; other site 441952002485 L-Asparaginase type 2. L-Asparaginase hydrolyzes L-asparagine to L-aspartate and ammonia. The proenzyme undergoes an autoproteolytic cleavage into alpha and beta subunits to expose a threonine residue which becomes the N-terminal residue of the beta...; Region: Asparaginase_2; cd04701 441952002486 catalytic nucleophile [active] 441952002487 Type 1 glutamine amidotransferase (GATase1)-like domain found in cyanophycinase; Region: GAT1_cyanophycinase; cd03145 441952002488 proposed catalytic triad [active] 441952002489 active site nucleophile [active] 441952002490 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 441952002491 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 441952002492 substrate binding site [chemical binding]; other site 441952002493 ATP binding site [chemical binding]; other site 441952002494 Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419 441952002495 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 441952002496 motif II; other site 441952002497 This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809 441952002498 Glycosyltransferases, probably involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG1215 441952002499 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 441952002500 active site 441952002501 Glycosyltransferases, probably involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG1215 441952002502 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 441952002503 active site 441952002504 LicD family; Region: LicD; cl01378 441952002505 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 441952002506 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 441952002507 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 441952002508 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 441952002509 active site 441952002510 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 441952002511 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 441952002512 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 441952002513 Walker A/P-loop; other site 441952002514 ATP binding site [chemical binding]; other site 441952002515 Q-loop/lid; other site 441952002516 ABC transporter signature motif; other site 441952002517 Walker B; other site 441952002518 D-loop; other site 441952002519 H-loop/switch region; other site 441952002520 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 441952002521 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_4; cd03795 441952002522 putative ADP-binding pocket [chemical binding]; other site 441952002523 UDP-glucose 4-epimerase; Region: PLN02240 441952002524 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 441952002525 NAD binding site [chemical binding]; other site 441952002526 homodimer interface [polypeptide binding]; other site 441952002527 active site 441952002528 substrate binding site [chemical binding]; other site 441952002529 exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025 441952002530 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 441952002531 Bacterial sugar transferase; Region: Bac_transf; cl00939 441952002532 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 441952002533 ribulose-phosphate 3-epimerase; Region: rpe; TIGR01163 441952002534 substrate binding site [chemical binding]; other site 441952002535 hexamer interface [polypeptide binding]; other site 441952002536 metal binding site [ion binding]; metal-binding site 441952002537 D-arabinose 5-phosphate isomerase; Provisional; Region: PRK10892 441952002538 KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014 441952002539 putative active site [active] 441952002540 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with KpsF/GutQ domains in the API [A5P (D-arabinose 5-phosphate) isomerase] protein. These APIs catalyze the conversion of the pentose pathway...; Region: CBS_pair_KpsF_GutQ_assoc; cd04604 441952002541 Uncharacterized protein conserved in bacteria (DUF2063); Region: DUF2063; cl01262 441952002542 Protein of unknown function (DUF692); Region: DUF692; cl01263 441952002543 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 441952002544 enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK06997 441952002545 Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372 441952002546 NAD binding site [chemical binding]; other site 441952002547 homotetramer interface [polypeptide binding]; other site 441952002548 homodimer interface [polypeptide binding]; other site 441952002549 substrate binding site [chemical binding]; other site 441952002550 active site 441952002551 Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695 441952002552 chaperone protein DnaJ; Provisional; Region: PRK10767 441952002553 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 441952002554 HSP70 interaction site [polypeptide binding]; other site 441952002555 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262 441952002556 substrate binding site [polypeptide binding]; other site 441952002557 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 441952002558 Zn binding sites [ion binding]; other site 441952002559 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 441952002560 dimer interface [polypeptide binding]; other site 441952002561 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 441952002562 Molecular chaperone GrpE (heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: GrpE; COG0576 441952002563 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 441952002564 dimer interface [polypeptide binding]; other site 441952002565 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 441952002566 Membrane-bound lytic murein transglycosylase [Cell envelope biogenesis, outer membrane]; Region: MltA; COG2821 441952002567 MltA specific insert domain; Region: MltA; cl08398 441952002568 3D domain; Region: 3D; cl01439 441952002569 Protoporphyrinogen oxidase [Coenzyme metabolism]; Region: HemY; COG1232 441952002570 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 441952002571 23S rRNA interface [nucleotide binding]; other site 441952002572 L3 interface [polypeptide binding]; other site 441952002573 Ribosomal protein S9/S16; Region: Ribosomal_S9; cl00334 441952002574 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 441952002575 Stringent starvation protein B; Region: SspB; cl01120 441952002576 Sodium:solute symporter family; Region: SSF; cl00456 441952002577 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 441952002578 RNA/DNA hybrid binding site [nucleotide binding]; other site 441952002579 active site 441952002580 tRNA (cytidine/uridine-2'-O-)-methyltransferase TrmJ; Provisional; Region: PRK15114 441952002581 SpoU rRNA Methylase family; Region: SpoU_methylase; cl00362 441952002582 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 441952002583 active site 441952002584 phosphorylation site [posttranslational modification] 441952002585 RaiA ('ribosome-associated inhibitor A', also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal A site; Region: RaiA; cd00552 441952002586 30S subunit binding site; other site 441952002587 tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291 441952002588 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 441952002589 trmE is a tRNA modification GTPase; Region: trmE; cd04164 441952002590 G1 box; other site 441952002591 GTP/Mg2+ binding site [chemical binding]; other site 441952002592 Switch I region; other site 441952002593 G2 box; other site 441952002594 Switch II region; other site 441952002595 G3 box; other site 441952002596 G4 box; other site 441952002597 G5 box; other site 441952002598 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 441952002599 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 441952002600 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 441952002601 dimer interface [polypeptide binding]; other site 441952002602 pyridoxal 5'-phosphate binding site [chemical binding]; other site 441952002603 catalytic residue [active] 441952002604 RNA polymerase beta'' subunit; Reviewed; Region: rpoC2; CHL00117 441952002605 Type VI protein secretion system component VasK [Intracellular trafficking, secretion, and vesicular transport]; Region: IcmF; COG3523 441952002606 Domain of unknown function (DUF4280); Region: DUF4280; pfam14107 441952002607 Uncharacterized protein conserved in bacteria (DUF2077); Region: DUF2077; cl01370 441952002608 Intracellular growth locus C protein; Region: IglC; pfam11550 441952002609 Protein of unknown function (DUF877); Region: DUF877; pfam05943 441952002610 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3517; cl05484 441952002611 Protein of unknown function (DUF770); Region: DUF770; cl01402 441952002612 Uncharacterized protein family (UPF0075); Region: UPF0075; cl04217 441952002613 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 441952002614 NAD synthase; Region: NAD_synthase; pfam02540 441952002615 homodimer interface [polypeptide binding]; other site 441952002616 NAD binding pocket [chemical binding]; other site 441952002617 ATP binding pocket [chemical binding]; other site 441952002618 Mg binding site [ion binding]; other site 441952002619 active-site loop [active] 441952002620 Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538 441952002621 efflux pump membrane protein (multidrug resistance protein A); Region: 8a0101; TIGR00998 441952002622 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 441952002623 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 441952002624 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 441952002625 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 441952002626 putative substrate translocation pore; other site 441952002627 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 441952002628 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 441952002629 Long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07059 441952002630 AMP-binding enzyme; Region: AMP-binding; cl15778 441952002631 dipeptide/tripeptide permease B; Provisional; Region: PRK10207 441952002632 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 441952002633 putative substrate translocation pore; other site 441952002634 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cl11420 441952002635 RNA methyltransferase; Region: Methyltrans_RNA; pfam04452 441952002636 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1385; cl00611 441952002637 Protein of unknown function (DUF445); Region: DUF445; pfam04286 441952002638 ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463 441952002639 mce related protein; Region: MCE; pfam02470 441952002640 ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127 441952002641 ABC (ATP-binding cassette) transport system involved in resistant to organic solvents; ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars, ions, peptides, and more complex...; Region: ABC_Org_Solvent_Resistant; cd03261 441952002642 Walker A/P-loop; other site 441952002643 ATP binding site [chemical binding]; other site 441952002644 Q-loop/lid; other site 441952002645 ABC transporter signature motif; other site 441952002646 Walker B; other site 441952002647 D-loop; other site 441952002648 H-loop/switch region; other site 441952002649 Permease; Region: Permease; cl00510 441952002650 23S rRNA pseudouridine synthase D; Provisional; Region: rluD; PRK11180 441952002651 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 441952002652 RNA binding surface [nucleotide binding]; other site 441952002653 PseudoU_synth_RsuA/RluD: Pseudouridine synthase, RsuA/RluD family. This group is comprised of eukaryotic, bacterial and archeal proteins similar to eight site specific Escherichia coli pseudouridine synthases: RsuA, RluA, RluB, RluC, RluD, RluE, RluF and...; Region: PseudoU_synth_RluCD_like; cd02869 441952002654 active site 441952002655 outer membrane assembly lipoprotein YfiO; Region: OM_YfiO; TIGR03302 441952002656 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 441952002657 Serine-pyruvate aminotransferase/archaeal aspartate aminotransferase [Amino acid transport and metabolism]; Region: COG0075 441952002658 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 441952002659 catalytic residue [active] 441952002660 cytidylate kinase; Provisional; Region: cmk; PRK00023 441952002661 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 441952002662 CMP-binding site; other site 441952002663 The sites determining sugar specificity; other site 441952002664 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 441952002665 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 441952002666 NAD(P) binding site [chemical binding]; other site 441952002667 active site 441952002668 Peroxiredoxin (PRX) family, PRX5-like subfamily; members are similar to the human protein, PRX5, a homodimeric TRX peroxidase, widely expressed in tissues and found cellularly in mitochondria, peroxisomes and the cytosol. The cellular location of PRX5...; Region: PRX5_like; cd03013 441952002669 catalytic triad [active] 441952002670 dimer interface [polypeptide binding]; other site 441952002671 DNA-binding transcriptional regulator OxyR; Provisional; Region: PRK11151 441952002672 Helix-turn-helix domains; Region: HTH; cl00088 441952002673 The C-terminal substrate-binding domain of the LysR-type transcriptional regulator OxyR, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_OxyR; cd08411 441952002674 dimerization interface [polypeptide binding]; other site 441952002675 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 441952002676 Transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this domain superfamily was previously known as DUF156; Region: CsoR-like_DUF156; cd10148 441952002677 putative homotetramer interface [polypeptide binding]; other site 441952002678 putative homodimer interface [polypeptide binding]; other site 441952002679 putative allosteric switch controlling residues; other site 441952002680 putative metal binding site [ion binding]; other site 441952002681 putative homodimer-homodimer interface [polypeptide binding]; other site 441952002682 Domain of unknown function (DUF1338); Region: DUF1338; cl02226 441952002683 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3014 441952002684 D-ala-D-ala dipeptidase; Region: Peptidase_M15; cl00813 441952002685 DNA polymerase III, epsilon subunit, Proteobacterial; Region: dnaQ_proteo; TIGR01406 441952002686 DEDDh 3'-5' exonuclease domain of the epsilon subunit of Escherichia coli DNA polymerase III and similar proteins; Region: DNA_pol_III_epsilon_Ecoli_like; cd06131 441952002687 active site 441952002688 substrate binding site [chemical binding]; other site 441952002689 catalytic site [active] 441952002690 PhnA protein; Region: PhnA; pfam03831 441952002691 peroxidase; Provisional; Region: PRK15000 441952002692 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 441952002693 dimer interface [polypeptide binding]; other site 441952002694 decamer (pentamer of dimers) interface [polypeptide binding]; other site 441952002695 catalytic triad [active] 441952002696 peroxidatic and resolving cysteines [active] 441952002697 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 441952002698 beta-phosphoglucomutase family hydrolase; Region: PGMB-YQAB-SF; TIGR02009 441952002699 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic 'goose-type' lysozymes (GEWL). LTs catalyze...; Region: LT_GEWL; cd00254 441952002700 N-acetyl-D-glucosamine binding site [chemical binding]; other site 441952002701 catalytic residue [active] 441952002702 Demethoxyubiquinone hydroxylase, ferritin-like diiron-binding domain; Region: DMQH; cd01042 441952002703 diiron binding motif [ion binding]; other site 441952002704 malate dehydrogenase; Reviewed; Region: PRK06223 441952002705 L-lactate dehydrogenase-like malate dehydrogenase proteins; Region: LDH-like_MDH; cd01339 441952002706 NAD(P) binding site [chemical binding]; other site 441952002707 dimer interface [polypeptide binding]; other site 441952002708 tetramer (dimer of dimers) interface [polypeptide binding]; other site 441952002709 substrate binding site [chemical binding]; other site 441952002710 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK09102 441952002711 Class I ribonucleotide reductase; Region: RNR_I; cd01679 441952002712 active site 441952002713 dimer interface [polypeptide binding]; other site 441952002714 catalytic residues [active] 441952002715 effector binding site; other site 441952002716 R2 peptide binding site; other site 441952002717 Glutaredoxin (GRX) family, GRX bacterial class 1 and 3 (b_1_3)-like subfamily; composed of bacterial GRXs, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, catalyzing the...; Region: GRX_GRXb_1_3_like; cd03418 441952002718 GSH binding site [chemical binding]; other site 441952002719 catalytic residues [active] 441952002720 bifunctional gluaredoxin/ribonucleoside-diphosphate reductase subunit beta; Provisional; Region: PRK12759 441952002721 Glutaredoxin (GRX) family, GRX bacterial class 1 and 3 (b_1_3)-like subfamily; composed of bacterial GRXs, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, catalyzing the...; Region: GRX_GRXb_1_3_like; cd03418 441952002722 GSH binding site [chemical binding]; other site 441952002723 catalytic residues [active] 441952002724 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 441952002725 dimer interface [polypeptide binding]; other site 441952002726 putative radical transfer pathway; other site 441952002727 diiron center [ion binding]; other site 441952002728 tyrosyl radical; other site 441952002729 Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693 441952002730 Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_2; cd03139 441952002731 conserved cys residue [active] 441952002732 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 441952002733 active site 441952002734 DNA polymerase IV; Validated; Region: PRK02406 441952002735 DNA binding site [nucleotide binding] 441952002736 Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196 441952002737 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 441952002738 Walker A/P-loop; other site 441952002739 ATP binding site [chemical binding]; other site 441952002740 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; cl14958 441952002741 N-6 DNA Methylase; Region: N6_Mtase; pfam02384 441952002742 putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737 441952002743 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 441952002744 FMN binding site [chemical binding]; other site 441952002745 active site 441952002746 catalytic residues [active] 441952002747 substrate binding site [chemical binding]; other site 441952002748 ribosomal protein L11 methyltransferase; Reviewed; Region: prmA; PRK00517 441952002749 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 441952002750 S-adenosylmethionine binding site [chemical binding]; other site 441952002751 Uncharacterized oxidoreductases, Fe-dependent alcohol dehydrogenase family [Energy production and conversion]; Region: COG1979 441952002752 Butanol dehydrogenase catalyzes the conversion of butyraldehyde to butanol with the cofactor NAD(P)H being oxidized in the process; Region: BDH; cd08187 441952002753 dimer interface [polypeptide binding]; other site 441952002754 active site 441952002755 metal binding site [ion binding]; metal-binding site 441952002756 L-lactate dehydrogenase; Provisional; Region: lldD; PRK11197 441952002757 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl09108 441952002758 phosphate binding site [ion binding]; other site 441952002759 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 441952002760 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 441952002761 active site 441952002762 HIGH motif; other site 441952002763 dimer interface [polypeptide binding]; other site 441952002764 KMSKS motif; other site 441952002765 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cl09940 441952002766 lipoate-protein ligase A; Provisional; Region: lplA; PRK03822 441952002767 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 441952002768 Protease HslV and the ATPase/chaperone HslU are part of an ATP-dependent proteolytic system that is the prokaryotic homolog of the proteasome. HslV is a dimer of hexamers (a dodecamer) that forms a central proteolytic chamber with active sites on the...; Region: protease_HslV; cd01913 441952002769 active site 441952002770 HslU subunit interaction site [polypeptide binding]; other site 441952002771 ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201 441952002772 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 441952002773 Walker A motif; other site 441952002774 ATP binding site [chemical binding]; other site 441952002775 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 441952002776 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; cl11083 441952002777 lysyl-tRNA synthetase; Provisional; Region: lysS; PRK02983 441952002778 Ion channel; Region: Ion_trans_2; cl11596 441952002779 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 441952002780 soluble pyridine nucleotide transhydrogenase; Provisional; Region: PRK05249 441952002781 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 441952002782 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 441952002783 Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989 441952002784 Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750 441952002785 Type IV leader peptidase family; Region: Peptidase_A24; cl02077 441952002786 DsbA family, DsbC and DsbG subfamily; V-shaped homodimeric proteins containing a redox active CXXC motif imbedded in a TRX fold. They function as protein disulfide isomerases and chaperones in the bacterial periplasm to correct non-native disulfide bonds...; Region: DsbA_DsbC_DsbG; cd03020 441952002787 dimerization domain [polypeptide binding]; other site 441952002788 dimer interface [polypeptide binding]; other site 441952002789 catalytic residues [active] 441952002790 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 441952002791 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 441952002792 putative active site [active] 441952002793 catalytic residue [active] 441952002794 GTP-binding protein YchF; Reviewed; Region: PRK09601 441952002795 YchF GTPase; Region: YchF; cd01900 441952002796 G1 box; other site 441952002797 GTP/Mg2+ binding site [chemical binding]; other site 441952002798 Switch I region; other site 441952002799 G2 box; other site 441952002800 Switch II region; other site 441952002801 G3 box; other site 441952002802 G4 box; other site 441952002803 G5 box; other site 441952002804 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 441952002805 Putative Mg2+ and Co2+ transporter CorB [Inorganic ion transport and metabolism]; Region: CorB; COG4536 441952002806 Domain of unknown function DUF21; Region: DUF21; pfam01595 441952002807 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 441952002808 Transporter associated domain; Region: CorC_HlyC; cl08393 441952002809 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 441952002810 5S rRNA interface [nucleotide binding]; other site 441952002811 CTC domain interface [polypeptide binding]; other site 441952002812 L16 interface [polypeptide binding]; other site 441952002813 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259 441952002814 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 441952002815 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 441952002816 active site 441952002817 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 441952002818 Major Facilitator Superfamily; Region: MFS_1; pfam07690 441952002819 putative substrate translocation pore; other site 441952002820 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 441952002821 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 441952002822 Nicotinamide mononucleotide transporter; Region: NMN_transporter; cl01256 441952002823 Isochorismatase family; Region: Isochorismatase; pfam00857 441952002824 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cl00220 441952002825 catalytic triad [active] 441952002826 conserved cis-peptide bond; other site 441952002827 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cl00214 441952002828 intersubunit interface [polypeptide binding]; other site 441952002829 active site 441952002830 Zn2+ binding site [ion binding]; other site 441952002831 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 441952002832 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 441952002833 catalytic residue [active] 441952002834 Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG3618 441952002835 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 441952002836 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: COG3264 441952002837 RmuC family; Region: RmuC; pfam02646 441952002838 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 441952002839 RuvA N terminal domain; Region: RuvA_N; pfam01330 441952002840 RuvA, C-terminal domain; Region: RuvA_C; pfam07499 441952002841 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 441952002842 Major Facilitator Superfamily; Region: MFS_1; pfam07690 441952002843 putative substrate translocation pore; other site 441952002844 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD includes...; Region: RuvC_resolvase; cd00529 441952002845 active site 441952002846 putative DNA-binding cleft [nucleotide binding]; other site 441952002847 dimer interface [polypeptide binding]; other site 441952002848 Transcriptional regulator; Region: Transcrip_reg; cl00361 441952002849 isoprenoid biosynthesis protein with amidotransferase-like domain; Provisional; Region: PRK11780 441952002850 Type 1 glutamine amidotransferase (GATase1)-like domain found in zebrafish ES1; Region: GATase1_ES1; cd03133 441952002851 conserved cys residue [active] 441952002852 lipoyl synthase; Provisional; Region: PRK05481 441952002853 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 441952002854 FeS/SAM binding site; other site 441952002855 nonheme-containing ferritins; Region: Nonheme_Ferritin; cd01055 441952002856 Ferritin-like domain; Region: Ferritin; pfam00210 441952002857 ferroxidase diiron center [ion binding]; other site 441952002858 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cl11420 441952002859 Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104 441952002860 glutaredoxin 2; Provisional; Region: PRK10387 441952002861 GST_N family, Glutaredoxin 2 (GRX2) subfamily; composed of bacterial proteins similar to E. coli GRX2, an atypical GRX with a molecular mass of about 24kD, compared with other GRXs which are 9-12kD in size. GRX2 adopts a GST fold containing an N-terminal...; Region: GST_N_GRX2; cd03037 441952002862 C-terminal domain interface [polypeptide binding]; other site 441952002863 GSH binding site (G-site) [chemical binding]; other site 441952002864 catalytic residues [active] 441952002865 putative dimer interface [polypeptide binding]; other site 441952002866 C-terminal, alpha helical domain of Glutaredoxin 2; Region: GST_C_GRX2; cd03199 441952002867 N-terminal domain interface [polypeptide binding]; other site 441952002868 electron transport complex protein RnfB; Provisional; Region: PRK05113 441952002869 Putative Fe-S cluster; Region: FeS; pfam04060 441952002870 4Fe-4S binding domain; Region: Fer4; cl02805 441952002871 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 441952002872 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 441952002873 minor groove reading motif; other site 441952002874 helix-hairpin-helix signature motif; other site 441952002875 substrate binding pocket [chemical binding]; other site 441952002876 active site 441952002877 Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; cl15304 441952002878 Domain of unknown function (DUF1841); Region: DUF1841; pfam08897 441952002879 YccA-like proteins; Region: YccA_like; cd10433 441952002880 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 441952002881 CarD-like/TRCF domain; Region: CarD_CdnL_TRCF; cl00588 441952002882 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 441952002883 ATP binding site [chemical binding]; other site 441952002884 putative Mg++ binding site [ion binding]; other site 441952002885 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 441952002886 nucleotide binding region [chemical binding]; other site 441952002887 ATP-binding site [chemical binding]; other site 441952002888 TRCF domain; Region: TRCF; cl04088 441952002889 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 441952002890 putative valine binding site [chemical binding]; other site 441952002891 dimer interface [polypeptide binding]; other site 441952002892 Dehydratase family; Region: ILVD_EDD; cl00340 441952002893 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 441952002894 non-specific DNA binding site [nucleotide binding]; other site 441952002895 salt bridge; other site 441952002896 sequence-specific DNA binding site [nucleotide binding]; other site 441952002897 HipA N-terminal domain; Region: Couple_hipA; cl11853 441952002898 Toxin module HipA, protein kinase of phosphatidylinositol 3/4-kinase superfamily [General function prediction only]; Region: HipA; COG3550 441952002899 HipA-like N-terminal domain; Region: HipA_N; pfam07805 441952002900 HipA-like C-terminal domain; Region: HipA_C; pfam07804 441952002901 Putative exonuclease, RdgC; Region: RdgC; cl01122 441952002902 putative rhodanese-related sulfurtransferase; Provisional; Region: PRK00142 441952002903 Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YceA, Bacillus subtilis YbfQ, and similar uncharacterized proteins; Region: RHOD_YceA; cd01518 441952002904 active site residue [active] 441952002905 ATP-dependent DNA helicase Rep; Region: rep; TIGR01074 441952002906 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 441952002907 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 441952002908 Family description; Region: UvrD_C_2; cl15862 441952002909 Predicted aminomethyltransferase related to GcvT [General function prediction only]; Region: COG0354 441952002910 folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317 441952002911 Isochorismatase family; Region: Isochorismatase; pfam00857 441952002912 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cl00220 441952002913 catalytic triad [active] 441952002914 conserved cis-peptide bond; other site 441952002915 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 441952002916 Isochorismatase family; Region: Isochorismatase; pfam00857 441952002917 catalytic triad [active] 441952002918 conserved cis-peptide bond; other site 441952002919 transaldolase-like protein; Provisional; Region: PTZ00411 441952002920 Transaldolases including both TalA and TalB; Region: Transaldolase_TalAB; cd00957 441952002921 active site 441952002922 dimer interface [polypeptide binding]; other site 441952002923 catalytic residue [active] 441952002924 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 441952002925 interface (dimer of trimers) [polypeptide binding]; other site 441952002926 Substrate-binding/catalytic site; other site 441952002927 Zn-binding sites [ion binding]; other site 441952002928 Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538 441952002929 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 441952002930 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent formation of...; Region: AlaRS_core; cd00673 441952002931 motif 1; other site 441952002932 active site 441952002933 motif 2; other site 441952002934 motif 3; other site 441952002935 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; cl08469 441952002936 Oligomerisation domain; Region: Oligomerisation; cl00519 441952002937 Domain amino terminal to FKBP-type peptidyl-prolyl isomerase; Region: FKBP_N; pfam01346 441952002938 DsbA family, Com1-like subfamily; composed of proteins similar to Com1, a 27-kDa outer membrane-associated immunoreactive protein originally found in both acute and chronic disease strains of the pathogenic bacteria Coxiella burnetti. It contains a CXXC...; Region: DsbA_Com1_like; cd03023 441952002939 catalytic residues [active] 441952002940 bifunctional methionine sulfoxide reductase B/A protein; Provisional; Region: PRK05550 441952002941 methionine sulfoxide reductase B; Provisional; Region: PRK00222; cl15841 441952002942 Peptide methionine sulfoxide reductase; Region: PMSR; cl00366 441952002943 BCCT family transporter; Region: BCCT; cl00569 441952002944 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 441952002945 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; cl06870 441952002946 SpoU rRNA Methylase family; Region: SpoU_methylase; cl00362 441952002947 The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467 441952002948 Linear amide C-N hydrolases, choloylglycine hydrolase family; Region: CBAH; pfam02275 441952002949 active site 441952002950 CRISPR/Cas system-associated protein Cas2; Region: Cas2_I_II_III; cd09725 441952002951 outer membrane protein A; Reviewed; Region: PRK10808 441952002952 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 441952002953 ligand binding site [chemical binding]; other site 441952002954 ferredoxin; Validated; Region: PRK07118 441952002955 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 441952002956 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 441952002957 active site 441952002958 (T/H)XGH motif; other site 441952002959 Domain of unknown function DUF59; Region: DUF59; cl00941 441952002960 Iron-sulphur cluster biosynthesis; Region: Fe-S_biosyn; cl00400 441952002961 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 441952002962 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 441952002963 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 441952002964 catalytic residue [active] 441952002965 L-serine dehydratase, iron-sulfur-dependent, single chain form; Region: sda_mono; TIGR00720 441952002966 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 441952002967 Serine dehydratase alpha chain; Region: SDH_alpha; cl12120 441952002968 Protein of unknown function DUF45; Region: DUF45; cl00636 441952002969 Prephenate dehydratase [Amino acid transport and metabolism]; Region: PheA; COG0077 441952002970 Prephenate dehydratase; Region: PDT; pfam00800 441952002971 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 441952002972 putative L-Phe binding site [chemical binding]; other site 441952002973 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 441952002974 Alanine racemase [Cell envelope biogenesis, outer membrane]; Region: Alr; COG0787 441952002975 active site 441952002976 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 441952002977 dimer interface [polypeptide binding]; other site 441952002978 substrate binding site [chemical binding]; other site 441952002979 catalytic residues [active] 441952002980 dipeptide/tripeptide permease B; Provisional; Region: PRK10207 441952002981 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cl11420 441952002982 GST_N family, Metaxin subfamily, Metaxin-like proteins; a heterogenous group of proteins, predominantly uncharacterized, with similarity to metaxins and GSTs. Metaxin 1 is a component of a preprotein import complex of the mitochondrial outer membrane. It...; Region: GST_N_Metaxin_like; cd03080 441952002983 putative C-terminal domain interface [polypeptide binding]; other site 441952002984 putative GSH binding site [chemical binding]; other site 441952002985 putative dimer interface [polypeptide binding]; other site 441952002986 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776 441952002987 dimer interface [polypeptide binding]; other site 441952002988 substrate binding pocket (H-site) [chemical binding]; other site 441952002989 C-terminal, alpha helical domain of Metaxin and related proteins; Region: GST_C_Metaxin; cd03193 441952002990 putative N-terminal domain interface [polypeptide binding]; other site 441952002991 Protein of unknown function (DUF3301); Region: DUF3301; pfam11743 441952002992 Integral membrane protein TerC family; Region: TerC; cl10468 441952002993 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 441952002994 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 441952002995 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cl11420 441952002996 RNA polymerase factor sigma-32; Reviewed; Region: PRK06596 441952002997 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 441952002998 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 441952002999 DNA binding residues [nucleotide binding] 441952003000 preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022 441952003001 SecD/SecF GG Motif; Region: Sec_GG; pfam07549 441952003002 Protein export membrane protein; Region: SecD_SecF; cl14618 441952003003 SecD export protein N-terminal TM region; Region: SecD-TM1; cl08136 441952003004 preprotein translocase subunit SecD; Reviewed; Region: secD; PRK05812 441952003005 SecD/SecF GG Motif; Region: Sec_GG; pfam07549 441952003006 Protein export membrane protein; Region: SecD_SecF; cl14618 441952003007 Preprotein translocase subunit; Region: YajC; cl00806 441952003008 Isochorismatase family; Region: Isochorismatase; pfam00857 441952003009 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 441952003010 catalytic triad [active] 441952003011 conserved cis-peptide bond; other site 441952003012 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; cl00409 441952003013 tRNA-guanine transglycosylases, various specificities; Region: tgt_general; TIGR00449 441952003014 Protein of unknown function (DUF3281); Region: DUF3281; pfam11685 441952003015 Protein of unknown function (DUF3281); Region: DUF3281; pfam11685 441952003016 Glycerol-3-phosphate acyltransferase; Region: G3P_acyltransf; cl00410 441952003017 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 441952003018 dimer interface [polypeptide binding]; other site 441952003019 conserved gate region; other site 441952003020 ABC-ATPase subunit interface; other site 441952003021 NMT1-like family; Region: NMT1_2; cl15260 441952003022 Transmembrane amino acid transporter protein; Region: Aa_trans; cl15776 441952003023 aromatic amino acid transport protein; Region: araaP; TIGR00837 441952003024 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 441952003025 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 441952003026 active site residue [active] 441952003027 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 441952003028 active site residue [active] 441952003029 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554 441952003030 homotrimer interaction site [polypeptide binding]; other site 441952003031 zinc binding site [ion binding]; other site 441952003032 CDP-binding sites; other site 441952003033 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 441952003034 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 441952003035 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 441952003036 cyanophycin synthetase; Provisional; Region: PRK14016 441952003037 ATP-grasp domain; Region: ATP-grasp_4; cl03087 441952003038 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 441952003039 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 441952003040 Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615 441952003041 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 441952003042 active site 441952003043 catalytic site [active] 441952003044 type IV-A pilus assembly ATPase PilB; Region: type_IV_pilB; TIGR02538 441952003045 Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157 441952003046 PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129 441952003047 Walker A motif; other site 441952003048 ATP binding site [chemical binding]; other site 441952003049 Walker B motif; other site 441952003050 Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459 441952003051 Type II secretion system (T2SS), protein F; Region: T2SF; cl00906 441952003052 Succinate:quinone oxidoreductase (SQR) and Quinol:fumarate reductase (QFR) family, transmembrane subunits; SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol, while QFR catalyzes the reverse reaction. SQR; Region: SQR_QFR_TM; cl00881 441952003053 Type II secretion system (T2SS), protein F; Region: T2SF; cl00906 441952003054 ferrochelatase; Reviewed; Region: hemH; PRK00035 441952003055 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 441952003056 C-terminal domain interface [polypeptide binding]; other site 441952003057 active site 441952003058 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 441952003059 active site 441952003060 N-terminal domain interface [polypeptide binding]; other site 441952003061 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 441952003062 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 441952003063 GIY-YIG motif/motif A; other site 441952003064 active site 441952003065 catalytic site [active] 441952003066 putative DNA binding site [nucleotide binding]; other site 441952003067 metal binding site [ion binding]; metal-binding site 441952003068 UvrB/uvrC motif; Region: UVR; pfam02151 441952003069 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 441952003070 ribonuclease D; Region: rnd; TIGR01388 441952003071 DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142 441952003072 putative active site [active] 441952003073 catalytic site [active] 441952003074 putative substrate binding site [chemical binding]; other site 441952003075 HRDC domain; Region: HRDC; cl02578 441952003076 drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710 441952003077 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 441952003078 putative substrate translocation pore; other site 441952003079 Uncharacterized protein conserved in bacteria (DUF2237); Region: DUF2237; cl01467 441952003080 Ribosomal L27 protein; Region: Ribosomal_L27; cl00359 441952003081 Ribosomal prokaryotic L21 protein; Region: Ribosomal_L21p; cl00382 441952003082 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 441952003083 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 441952003084 SecA preprotein cross-linking domain; Region: SecA_PP_bind; cl03078 441952003085 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 441952003086 nucleotide binding region [chemical binding]; other site 441952003087 ATP-binding site [chemical binding]; other site 441952003088 hypothetical protein; Provisional; Region: PRK05590 441952003089 SEC-C motif; Region: SEC-C; pfam02810 441952003090 LPP20 lipoprotein; Region: LPP20; cl15824 441952003091 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 441952003092 Uridine phosphorylase [Nucleotide transport and metabolism]; Region: Udp; COG2820 441952003093 ATP-dependent metalloprotease; Reviewed; Region: hflB; PRK10733 441952003094 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 441952003095 Walker A motif; other site 441952003096 ATP binding site [chemical binding]; other site 441952003097 Walker B motif; other site 441952003098 arginine finger; other site 441952003099 Peptidase family M41; Region: Peptidase_M41; pfam01434 441952003100 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 441952003101 The excision repair protein UvrA domain I; Nucleotide excision repair in eubacteria is a process that repairs DNA damage by the removal of a 12-13-mer oligonucleotide containing the lesion. Recognition and cleavage of the damaged DNA is a multistep...; Region: ABC_UvrA_I; cd03270 441952003102 The excision repair protein UvrA domain I; Nucleotide excision repair in eubacteria is a process that repairs DNA damage by the removal of a 12-13-mer oligonucleotide containing the lesion. Recognition and cleavage of the damaged DNA is a multistep...; Region: ABC_UvrA_I; cd03270 441952003103 The excision repair protein UvrA domain II; Nucleotide excision repair in eubacteria is a process that repairs DNA damage by the removal of a 12-13-mer oligonucleotide containing the lesion. Recognition and cleavage of the damaged DNA is a multistep...; Region: ABC_UvrA_II; cd03271 441952003104 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 441952003105 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 441952003106 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 441952003107 Type II transport protein GspH; Region: GspH; pfam12019 441952003108 glucose-6-phosphate isomerase; Reviewed; Region: pgi; PRK00179 441952003109 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 441952003110 active site 441952003111 dimer interface [polypeptide binding]; other site 441952003112 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 441952003113 dimer interface [polypeptide binding]; other site 441952003114 active site 441952003115 Thiamine pyrophosphokinase; Region: TPK; cd07995 441952003116 thiamine pyrophosphokinase; Region: thi_PPkinase; TIGR01378 441952003117 active site 441952003118 dimerization interface [polypeptide binding]; other site 441952003119 thiamine binding site [chemical binding]; other site 441952003120 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 441952003121 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl09108 441952003122 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a key...; Region: CBS_pair_IMPDH; cd04601 441952003123 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of the guanine...; Region: IMPDH; cd00381 441952003124 active site 441952003125 multifunctional aminopeptidase A; Provisional; Region: PRK00913 441952003126 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 441952003127 interface (dimer of trimers) [polypeptide binding]; other site 441952003128 Substrate-binding/catalytic site; other site 441952003129 Zn-binding sites [ion binding]; other site 441952003130 Predicted permeases [General function prediction only]; Region: COG0795; cl12074 441952003131 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 441952003132 Predicted permeases [General function prediction only]; Region: COG0795; cl12074 441952003133 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 441952003134 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 441952003135 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 441952003136 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 441952003137 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 441952003138 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 441952003139 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 441952003140 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl15754 441952003141 Predicted membrane protein [Function unknown]; Region: COG2860 441952003142 UPF0126 domain; Region: UPF0126; pfam03458 441952003143 UPF0126 domain; Region: UPF0126; pfam03458 441952003144 MiaE tRNA-modifying nonheme diiron monooxygenase, ferritin-like diiron-binding domain; Region: MiaE; cd07910 441952003145 active site 441952003146 dinuclear metal binding site [ion binding]; other site 441952003147 dimerization interface [polypeptide binding]; other site 441952003148 Uridine phosphorylase [Nucleotide transport and metabolism]; Region: Udp; COG2820 441952003149 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 441952003150 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 441952003151 active site 441952003152 catalytic motif [active] 441952003153 Zn binding site [ion binding]; other site 441952003154 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 441952003155 FAD binding domain; Region: FAD_binding_4; pfam01565 441952003156 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 441952003157 Sulfatase; Region: Sulfatase; cl10460 441952003158 Phosphoglyceromutase [Carbohydrate transport and metabolism]; Region: GpmI; COG0696 441952003159 seryl-tRNA synthetase; Provisional; Region: PRK05431 441952003160 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 441952003161 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme bound...; Region: SerRS_core; cd00770 441952003162 dimer interface [polypeptide binding]; other site 441952003163 active site 441952003164 motif 1; other site 441952003165 motif 2; other site 441952003166 motif 3; other site 441952003167 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 441952003168 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 441952003169 MatE; Region: MatE; cl10513 441952003170 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 441952003171 cysteine/glutathione ABC transporter membrane/ATP-binding component; Reviewed; Region: PRK11174 441952003172 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 441952003173 Walker A/P-loop; other site 441952003174 ATP binding site [chemical binding]; other site 441952003175 Q-loop/lid; other site 441952003176 ABC transporter signature motif; other site 441952003177 Walker B; other site 441952003178 D-loop; other site 441952003179 H-loop/switch region; other site 441952003180 cysteine/glutathione ABC transporter membrane/ATP-binding component; Reviewed; Region: PRK11160 441952003181 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 441952003182 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 441952003183 Walker A/P-loop; other site 441952003184 ATP binding site [chemical binding]; other site 441952003185 Q-loop/lid; other site 441952003186 ABC transporter signature motif; other site 441952003187 Walker B; other site 441952003188 D-loop; other site 441952003189 H-loop/switch region; other site 441952003190 Sodium:dicarboxylate symporter family; Region: SDF; cl00573 441952003191 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 441952003192 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 441952003193 homotrimer interaction site [polypeptide binding]; other site 441952003194 putative active site [active] 441952003195 ABC-2 type transporter; Region: ABC2_membrane; cl11417 441952003196 Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566 441952003197 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 441952003198 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 441952003199 Glycerophosphodiester phosphodiesterase domain of putative Silicibacter pomeroyi glycerophosphodiester phosphodiesterase and similar proteins; Region: GDPD_SpGDE_like; cd08567 441952003200 active site 441952003201 catalytic site [active] 441952003202 metal binding site [ion binding]; metal-binding site 441952003203 Sugar phosphate permease [Carbohydrate transport and metabolism]; Region: UhpC; COG2271 441952003204 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 441952003205 putative substrate translocation pore; other site 441952003206 Heme-dependent peroxidases similar to plant peroxidases; Region: plant_peroxidase_like; cl00196 441952003207 catalase/hydroperoxidase HPI(I); Provisional; Region: PRK15061 441952003208 heme binding site [chemical binding]; other site 441952003209 C-terminal non-catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_2; cd08200 441952003210 deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional; Region: PRK05318 441952003211 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 441952003212 Zn2+ binding site [ion binding]; other site 441952003213 Mg2+ binding site [ion binding]; other site 441952003214 Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286 441952003215 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 441952003216 metabolite-proton symporter; Region: 2A0106; TIGR00883 441952003217 putative substrate translocation pore; other site 441952003218 5-carboxymethyl-2-hydroxymuconate isomerase (CHMI) is a trimeric enzyme catalyzing the isomerization of the unsaturated ketone 5-(carboxymethyl)-2-hydroxymuconate to 5-(carboxymethyl)-2-oxo-3-hexene-1,6-dionate. This is one step in the...; Region: CHMI; cd00580 441952003219 putative substrate binding pocket [chemical binding]; other site 441952003220 trimer interface [polypeptide binding]; other site 441952003221 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 441952003222 active site 441952003223 The GH18 (glycosyl hydrolase, family 18) type II chitinases hydrolyze chitin, an abundant polymer of beta-1,4-linked N-acetylglucosamine (GlcNAc) which is a major component of the cell wall of fungi and the exoskeleton of arthropods. Chitinases have...; Region: GH18_chitinase-like; cl10447 441952003224 Glyco_18 domain; Region: Glyco_18; smart00636 441952003225 active site 441952003226 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 441952003227 Chitin/cellulose binding domain. Putative carbohydrate binding domain found in many different glycosyl hydrolase enzymes. May occur in tandem arrangements; Region: ChtBD3; cd00036 441952003228 chitin/cellulose binding site [chemical binding]; other site 441952003229 Chitin/cellulose binding domain. Putative carbohydrate binding domain found in many different glycosyl hydrolase enzymes. May occur in tandem arrangements; Region: ChtBD3; cd00036 441952003230 chitin/cellulose binding site [chemical binding]; other site 441952003231 7-keto-8-aminopelargonate synthetase and related enzymes [Coenzyme metabolism]; Region: BioF; COG0156 441952003232 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454 441952003233 substrate-cofactor binding pocket; other site 441952003234 pyridoxal 5'-phosphate binding site [chemical binding]; other site 441952003235 catalytic residue [active] 441952003236 L-threonine 3-dehydrogenase; Validated; Region: tdh; PRK05396 441952003237 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 441952003238 NAD(P) binding site [chemical binding]; other site 441952003239 Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814 441952003240 Transmembrane amino acid transporter protein; Region: Aa_trans; cl15776 441952003241 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 441952003242 substrate binding site; other site 441952003243 dimer interface; other site 441952003244 Septum formation initiator; Region: DivIC; cl11433 441952003245 enolase; Provisional; Region: eno; PRK00077 441952003246 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 441952003247 dimer interface [polypeptide binding]; other site 441952003248 metal binding site [ion binding]; metal-binding site 441952003249 substrate binding pocket [chemical binding]; other site 441952003250 Major Facilitator Superfamily; Region: MFS_1; pfam07690 441952003251 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 441952003252 putative substrate translocation pore; other site 441952003253 Nicotinamide mononucleotide transporter; Region: NMN_transporter; cl01256 441952003254 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 441952003255 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 441952003256 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 441952003257 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 441952003258 23S rRNA m(5)U1939 methyltransferase; Reviewed; Region: rumA; PRK13168 441952003259 TRAM domain; Region: TRAM; cl01282 441952003260 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 441952003261 S-adenosylmethionine binding site [chemical binding]; other site 441952003262 RNA polymerase Rpb6; Region: RNA_pol_Rpb6; cl14651 441952003263 Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage pathway; Region: UMPK; cd02023 441952003264 ATP-binding site [chemical binding]; other site 441952003265 Sugar specificity; other site 441952003266 Pyrimidine base specificity; other site 441952003267 NeuB family; Region: NeuB; cl00496 441952003268 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 441952003269 Iron-sulphur cluster biosynthesis; Region: Fe-S_biosyn; cl00400 441952003270 polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824 441952003271 RNase PH-like 3'-5' exoribonucleases; Region: RNase_PH; cl03114 441952003272 oligomer interface [polypeptide binding]; other site 441952003273 RNA binding site [nucleotide binding]; other site 441952003274 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 441952003275 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 441952003276 RNase E interface [polypeptide binding]; other site 441952003277 trimer interface [polypeptide binding]; other site 441952003278 active site 441952003279 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 441952003280 putative nucleic acid binding region [nucleotide binding]; other site 441952003281 G-X-X-G motif; other site 441952003282 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 441952003283 RNA binding site [nucleotide binding]; other site 441952003284 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 441952003285 16S/18S rRNA binding site [nucleotide binding]; other site 441952003286 S13e-L30e interaction site [polypeptide binding]; other site 441952003287 25S rRNA binding site [nucleotide binding]; other site 441952003288 peptidoglycan synthase FtsI; Provisional; Region: PRK15105 441952003289 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 441952003290 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 441952003291 Septum formation initiator; Region: DivIC; cl11433 441952003292 Predicted S-adenosylmethionine-dependent methyltransferase involved in cell envelope biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG0275 441952003293 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 441952003294 O-succinylbenzoic acid--CoA ligase; Provisional; Region: PRK03640 441952003295 AMP-binding enzyme; Region: AMP-binding; cl15778 441952003296 formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103 441952003297 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 441952003298 DNA binding site [nucleotide binding] 441952003299 catalytic residue [active] 441952003300 H2TH interface [polypeptide binding]; other site 441952003301 putative catalytic residues [active] 441952003302 turnover-facilitating residue; other site 441952003303 intercalation triad [nucleotide binding]; other site 441952003304 8OG recognition residue [nucleotide binding]; other site 441952003305 putative reading head residues; other site 441952003306 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 441952003307 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 441952003308 Glutamine Amidotransferase (GATase_I) involved in pyridoxine biosynthesis; Region: GATase1_PB; cd01749 441952003309 predicted active site [active] 441952003310 catalytic triad [active] 441952003311 pyridoxal 5'-phosphate synthase, synthase subunit Pdx1; Region: TIGR00343 441952003312 PdxS is a subunit of the pyridoxal 5'-phosphate (PLP) synthase, an important enzyme in deoxyxylulose 5-phosphate (DXP)-independent pathway for de novo biosynthesis of PLP, present in some eubacteria, in archaea, fungi, plants, plasmodia, and some...; Region: pdxS; cd04727 441952003313 active site 441952003314 multimer interface [polypeptide binding]; other site 441952003315 DNA gyrase subunit B; Provisional; Region: gyrB; PRK14939 441952003316 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 441952003317 Mg2+ binding site [ion binding]; other site 441952003318 G-X-G motif; other site 441952003319 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 441952003320 anchoring element; other site 441952003321 dimer interface [polypeptide binding]; other site 441952003322 ATP binding site [chemical binding]; other site 441952003323 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 441952003324 active site 441952003325 putative metal-binding site [ion binding]; other site 441952003326 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 441952003327 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cl15777 441952003328 putative active site pocket [active] 441952003329 dimerization interface [polypeptide binding]; other site 441952003330 putative catalytic residue [active] 441952003331 tRNA-dihydrouridine synthase A; Provisional; Region: PRK11815 441952003332 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 441952003333 FMN binding site [chemical binding]; other site 441952003334 active site 441952003335 catalytic residues [active] 441952003336 substrate binding site [chemical binding]; other site 441952003337 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 441952003338 Uncharacterized protein conserved in bacteria (DUF2062); Region: DUF2062; cl01261 441952003339 TIGR03545 family protein; Region: TIGR03545 441952003340 TIGR03545 family protein; Region: TIGR03545 441952003341 succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696 441952003342 ATP-grasp domain; Region: ATP-grasp_4; cl03087 441952003343 CoA-ligase; Region: Ligase_CoA; cl02894 441952003344 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 441952003345 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 441952003346 CoA-ligase; Region: Ligase_CoA; cl02894 441952003347 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 441952003348 ATP-grasp domain; Region: ATP-grasp_4; cl03087 441952003349 Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104 441952003350 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cl11420 441952003351 Glycosylasparaginase catalyzes the hydrolysis of the glycosylamide bond of asparagine-linked glycoproteins. This enzyme is an amidase located inside lysosomes. Mutation of this gene in humans causes a genetic disorder known as aspartylglycosaminuria (AGU)...; Region: Glycosylasparaginase; cd04513 441952003352 active site 441952003353 dimer interface [polypeptide binding]; other site 441952003354 catalytic nucleophile [active] 441952003355 Domain of Unknown Function (DUF1543); Region: DUF1543; pfam07566 441952003356 CutC family; Region: CutC; cl01218 441952003357 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 441952003358 Major Facilitator Superfamily; Region: MFS_1; pfam07690 441952003359 putative substrate translocation pore; other site 441952003360 phosphoglycolate phosphatase; Provisional; Region: PRK13222 441952003361 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 441952003362 motif II; other site 441952003363 thioredoxin reductase; Provisional; Region: PRK10262 441952003364 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 441952003365 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 441952003366 putative substrate translocation pore; other site 441952003367 DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095 441952003368 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 441952003369 ATP binding site [chemical binding]; other site 441952003370 Mg2+ binding site [ion binding]; other site 441952003371 G-X-G motif; other site 441952003372 MutL_Trans_MutL: transducer domain, having a ribosomal S5 domain 2-like fold, found in proteins similar to Escherichia coli MutL. EcMutL belongs to the DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second...; Region: MutL_Trans_MutL; cd03482 441952003373 ATP binding site [chemical binding]; other site 441952003374 MutL C terminal dimerisation domain; Region: MutL_C; cl07336 441952003375 Uncharacterized protein conserved in bacteria (DUF2147); Region: DUF2147; cl01951 441952003376 Uncharacterized protein conserved in bacteria (DUF2147); Region: DUF2147; cl01951 441952003377 GTPase RsgA; Reviewed; Region: PRK00098 441952003378 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 441952003379 RNA binding site [nucleotide binding]; other site 441952003380 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 441952003381 GTPase/Zn-binding domain interface [polypeptide binding]; other site 441952003382 GTP/Mg2+ binding site [chemical binding]; other site 441952003383 G4 box; other site 441952003384 G5 box; other site 441952003385 G1 box; other site 441952003386 Switch I region; other site 441952003387 G2 box; other site 441952003388 G3 box; other site 441952003389 Switch II region; other site 441952003390 Protein of unknown function (DUF3281); Region: DUF3281; pfam11685 441952003391 putrescine transporter subunit: periplasmic-binding component of ABC superfamily; Provisional; Region: PRK10682 441952003392 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 441952003393 putative glutamate/gamma-aminobutyrate antiporter; Region: put_Glu_GABA_T; TIGR03813 441952003394 pheromone autoinducer 2 transporter; Reviewed; Region: tqsA; cl00465 441952003395 single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644 441952003396 DHH family; Region: DHH; pfam01368 441952003397 DHHA1 domain; Region: DHHA1; pfam02272 441952003398 Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340 441952003399 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 441952003400 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it attaches...; Region: class_II_aaRS-like_core; cl00268 441952003401 EF-P lysine aminoacylase GenX; Region: genX; TIGR00462 441952003402 motif 1; other site 441952003403 dimer interface [polypeptide binding]; other site 441952003404 active site 441952003405 motif 2; other site 441952003406 motif 3; other site 441952003407 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 441952003408 Mechanosensitive ion channel; Region: MS_channel; pfam00924 441952003409 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 441952003410 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 441952003411 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 441952003412 ATP-grasp domain; Region: ATP-grasp_4; cl03087 441952003413 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; cl08365 441952003414 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302 441952003415 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 441952003416 carboxyltransferase (CT) interaction site; other site 441952003417 biotinylation site [posttranslational modification]; other site 441952003418 Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466 441952003419 trimer interface [polypeptide binding]; other site 441952003420 active site 441952003421 dimer interface [polypeptide binding]; other site 441952003422 diadenosine tetraphosphatase; Reviewed; Region: apaH; PRK00166 441952003423 Escherichia coli ApaH and related proteins, metallophosphatase domain; Region: MPP_ApaH; cd07422 441952003424 active site 441952003425 metal binding site [ion binding]; metal-binding site 441952003426 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 441952003427 peptidyl-prolyl cis-trans isomerase SurA; Provisional; Region: PRK10770 441952003428 SurA N-terminal domain; Region: SurA_N_3; cl07813 441952003429 PPIC-type PPIASE domain; Region: Rotamase; cl08278 441952003430 PPIC-type PPIASE domain; Region: Rotamase; cl08278 441952003431 Organic solvent tolerance protein; Region: OstA_C; pfam04453 441952003432 Arginyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Region: ArgS; COG0018 441952003433 Arginyl tRNA synthetase N terminal domain; Region: Arg_tRNA_synt_N; cl04104 441952003434 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 441952003435 active site 441952003436 HIGH motif; other site 441952003437 nucleotide binding site [chemical binding]; other site 441952003438 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 441952003439 KMSK motif region; other site 441952003440 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 441952003441 tRNA binding surface [nucleotide binding]; other site 441952003442 anticodon binding site; other site 441952003443 SpoU rRNA Methylase family; Region: SpoU_methylase; cl00362 441952003444 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cd00384 441952003445 dimer interface [polypeptide binding]; other site 441952003446 active site 441952003447 Schiff base residues; other site 441952003448 CRS1 / YhbY (CRM) domain; Region: CRS1_YhbY; cl00663 441952003449 DNA polymerase III, delta subunit; Region: DNA_pol3_delta2; pfam13177 441952003450 DNA polymerase III subunit delta'; Validated; Region: PRK07993 441952003451 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 441952003452 putative inner membrane peptidase; Provisional; Region: PRK11778 441952003453 Peptidase family S49 N-terminal; Region: Peptidase_S49_N; pfam08496 441952003454 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 441952003455 tandem repeat interface [polypeptide binding]; other site 441952003456 oligomer interface [polypeptide binding]; other site 441952003457 active site residues [active] 441952003458 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 441952003459 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 441952003460 C-terminal, alpha helical domain of Stringent starvation protein A; Region: GST_C_SspA; cd03186 441952003461 dimer interface [polypeptide binding]; other site 441952003462 N-terminal domain interface [polypeptide binding]; other site 441952003463 DsrC like protein; Region: DsrC; cl01101 441952003464 Bacterial Fe(2+) trafficking; Region: Iron_traffic; cl01104 441952003465 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl15769 441952003466 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 441952003467 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 441952003468 Ligand binding site; other site 441952003469 Putative Catalytic site; other site 441952003470 DXD motif; other site 441952003471 Endoplasmic reticulum-based factor for assembly of V-ATPase; Region: Vma12; pfam11712 441952003472 YdjC-like protein; Region: YdjC; cl01344 441952003473 Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511 441952003474 UDP-N-acetylmuramoylalanine-D-glutamate ligase [Cell envelope biogenesis, outer membrane]; Region: MurD; COG0771 441952003475 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 441952003476 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 441952003477 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 441952003478 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 441952003479 Mg++ binding site [ion binding]; other site 441952003480 putative catalytic motif [active] 441952003481 putative substrate binding site [chemical binding]; other site 441952003482 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_HprK; cl00270 441952003483 active site 441952003484 metal-binding site [ion binding] 441952003485 nucleotide-binding site [chemical binding]; other site 441952003486 glutaminyl-tRNA synthetase; Provisional; Region: PRK05347 441952003487 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 441952003488 active site 441952003489 HIGH motif; other site 441952003490 nucleotide binding site [chemical binding]; other site 441952003491 catalytic core domain of glutaminyl-tRNA synthetase; Region: GlnRS_core; cd00807 441952003492 KMSKS motif; other site 441952003493 tRNA synthetases class I (E and Q), anti-codon binding domain; Region: tRNA-synt_1c_C; pfam03950 441952003494 ABC transporter ATPase component; Reviewed; Region: PRK11147 441952003495 This family of ATP-binding proteins belongs to a multisubunit transporter involved in drug resistance (BcrA and DrrA), nodulation, lipid transport, and lantibiotic immunity. In bacteria and archaea, these transporters usually include an ATP-binding...; Region: ABC_DR_subfamily_A; cd03230 441952003496 Walker A/P-loop; other site 441952003497 ATP binding site [chemical binding]; other site 441952003498 Q-loop/lid; other site 441952003499 ABC transporter signature motif; other site 441952003500 Walker B; other site 441952003501 D-loop; other site 441952003502 H-loop/switch region; other site 441952003503 ABC transporter; Region: ABC_tran_2; pfam12848 441952003504 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 441952003505 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 441952003506 putative substrate translocation pore; other site 441952003507 Predicted membrane protein [Function unknown]; Region: COG4129 441952003508 Fusaric acid resistance protein-like; Region: FUSC_2; cl15844 441952003509 Protein of unknown function (DUF1275); Region: DUF1275; cl01453 441952003510 Predicted acetyltransferase [General function prediction only]; Region: COG3153 441952003511 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 441952003512 LysE type translocator; Region: LysE; cl00565 441952003513 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK03708 441952003514 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; cl01255 441952003515 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 441952003516 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 441952003517 Ligand binding site; other site 441952003518 Putative Catalytic site; other site 441952003519 DXD motif; other site 441952003520 ABC-2 type transporter; Region: ABC2_membrane; cl11417 441952003521 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 441952003522 The ABCA subfamily mediates the transport of a variety of lipid compounds. Mutations of members of ABCA subfamily are associated with human genetic diseases, such as, familial high-density lipoprotein (HDL) deficiency, neonatal surfactant deficiency; Region: ABC_subfamily_A; cd03263 441952003523 Walker A/P-loop; other site 441952003524 ATP binding site [chemical binding]; other site 441952003525 Q-loop/lid; other site 441952003526 ABC transporter signature motif; other site 441952003527 Walker B; other site 441952003528 D-loop; other site 441952003529 H-loop/switch region; other site 441952003530 Predicted permeases [General function prediction only]; Region: COG0730; cl00498 441952003531 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 441952003532 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 441952003533 active site 441952003534 Ferritin-like domain; Region: Ferritin; pfam00210 441952003535 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657 441952003536 dinuclear metal binding motif [ion binding]; other site 441952003537 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 441952003538 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 441952003539 dimer interface [polypeptide binding]; other site 441952003540 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; cl11613 441952003541 Ppx/GppA phosphatase family; Region: Ppx-GppA; cl15449 441952003542 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 441952003543 catalytic residues [active] 441952003544 transcription termination factor Rho; Provisional; Region: rho; PRK09376 441952003545 Rho termination factor, N-terminal domain; Region: Rho_N; cl06505 441952003546 Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459 441952003547 RNA binding site [nucleotide binding]; other site 441952003548 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128 441952003549 multimer interface [polypeptide binding]; other site 441952003550 Walker A motif; other site 441952003551 ATP binding site [chemical binding]; other site 441952003552 Walker B motif; other site 441952003553 Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109 441952003554 ManB is a bacterial phosphomannomutase (PMM) that catalyzes the conversion of mannose 6-phosphate to mannose-1-phosphate in the second of three steps in the GDP-mannose pathway, in which GDP-D-mannose is synthesized from fructose-6-phosphate. In...; Region: ManB; cd03088 441952003555 active site 441952003556 substrate binding site [chemical binding]; other site 441952003557 metal binding site [ion binding]; metal-binding site 441952003558 mannose-1-phosphate guanylyltransferase/mannose-6-phosphate isomerase; Region: GMP_PMI; TIGR01479 441952003559 GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509 441952003560 Substrate binding site; other site 441952003561 Cupin domain; Region: Cupin_2; cl09118 441952003562 dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088 441952003563 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 441952003564 NAD binding site [chemical binding]; other site 441952003565 substrate binding site [chemical binding]; other site 441952003566 homodimer interface [polypeptide binding]; other site 441952003567 active site 441952003568 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538 441952003569 glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207 441952003570 substrate binding site; other site 441952003571 tetramer interface; other site 441952003572 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 441952003573 active site 441952003574 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 441952003575 MatE; Region: MatE; cl10513 441952003576 hypothetical protein; Provisional; Region: PRK07579 441952003577 Formyltransferase, catalytic core domain; Region: FMT_core; cl00395 441952003578 active site 441952003579 cosubstrate binding site; other site 441952003580 substrate binding site [chemical binding]; other site 441952003581 catalytic site [active] 441952003582 DegT/DnrJ/EryC1/StrS aminotransferase family; Region: DegT_DnrJ_EryC1; pfam01041 441952003583 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 441952003584 inhibitor-cofactor binding pocket; inhibition site 441952003585 pyridoxal 5'-phosphate binding site [chemical binding]; other site 441952003586 catalytic residue [active] 441952003587 Asparagine synthase (glutamine-hydrolyzing) [Amino acid transport and metabolism]; Region: AsnB; COG0367 441952003588 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 441952003589 active site 441952003590 dimer interface [polypeptide binding]; other site 441952003591 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 441952003592 Ligand Binding Site [chemical binding]; other site 441952003593 Molecular Tunnel; other site 441952003594 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 441952003595 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 441952003596 This family is most closely related to the GT1 family of glycosyltransferases. WbnK in Shigella dysenteriae has been shown to be involved in the type 7 O-antigen biosynthesis; Region: GT1_WbnK_like; cd03807 441952003597 putative ADP-binding pocket [chemical binding]; other site 441952003598 Vi polysaccharide biosynthesis protein TviC; Provisional; Region: PRK15181 441952003599 UDP-N-acetylglucosamine 4-epimerase, extended (e) SDRs; Region: UDP_AE_SDR_e; cd05256 441952003600 NAD binding site [chemical binding]; other site 441952003601 substrate binding site [chemical binding]; other site 441952003602 homodimer interface [polypeptide binding]; other site 441952003603 active site 441952003604 Vi polysaccharide biosynthesis protein TviB; Provisional; Region: PRK15182 441952003605 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 441952003606 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 441952003607 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 441952003608 This family is most closely related to the GT1 family of glycosyltransferases. cap1E in Streptococcus pneumoniae is required for the synthesis of type 1 capsular polysaccharides; Region: GT1_cap1E_like; cd03808 441952003609 putative ADP-binding pocket [chemical binding]; other site 441952003610 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 441952003611 NADH(P)-binding; Region: NAD_binding_10; pfam13460 441952003612 NAD(P) binding site [chemical binding]; other site 441952003613 active site 441952003614 Bacterial sugar transferase; Region: Bac_transf; cl00939 441952003615 Predicted nucleoside-diphosphate sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG1086 441952003616 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 441952003617 UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237 441952003618 NAD(P) binding site [chemical binding]; other site 441952003619 homodimer interface [polypeptide binding]; other site 441952003620 substrate binding site [chemical binding]; other site 441952003621 active site 441952003622 glutamate dehydrogenase; Provisional; Region: PRK09414 441952003623 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 441952003624 NAD(P) binding domain of glutamate dehydrogenase, subgroup 2; Region: NAD_bind_2_Glu_DH; cd05313 441952003625 NAD(P) binding site [chemical binding]; other site 441952003626 Glycosyltransferase sugar-binding region containing DXD motif; Region: Gly_transf_sug; pfam04488 441952003627 Ribosomal protein L17; Region: Ribosomal_L17; cl00356 441952003628 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 441952003629 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 441952003630 alphaNTD homodimer interface [polypeptide binding]; other site 441952003631 alphaNTD - beta interaction site [polypeptide binding]; other site 441952003632 alphaNTD - beta' interaction site [polypeptide binding]; other site 441952003633 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; cl11613 441952003634 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 441952003635 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 441952003636 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 441952003637 RNA binding surface [nucleotide binding]; other site 441952003638 Ribosomal protein S11; Region: Ribosomal_S11; cl00332 441952003639 Ribosomal protein S13/S18; Region: Ribosomal_S13; cl00331 441952003640 Ribosomal protein S13 [Translation, ribosomal structure and biogenesis]; Region: RpsM; COG0099 441952003641 Ribosomal protein L36; Region: Ribosomal_L36; cl00380 441952003642 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 441952003643 SecY translocase; Region: SecY; pfam00344 441952003644 Ribosomal protein L18e/L15; Region: Ribosomal_L18e; cl12022 441952003645 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 441952003646 23S rRNA binding site [nucleotide binding]; other site 441952003647 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 441952003648 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 441952003649 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 441952003650 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 441952003651 23S rRNA interface [nucleotide binding]; other site 441952003652 L21e interface [polypeptide binding]; other site 441952003653 5S rRNA interface [nucleotide binding]; other site 441952003654 L27 interface [polypeptide binding]; other site 441952003655 L5 interface [polypeptide binding]; other site 441952003656 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 441952003657 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 441952003658 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 441952003659 Ribosomal protein S8; Region: Ribosomal_S8; cl00330 441952003660 Ribosomal protein S14p/S29e; Region: Ribosomal_S14; cl00355 441952003661 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 441952003662 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 441952003663 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 441952003664 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 441952003665 KOW motif; Region: KOW; cl00354 441952003666 Ribosomal protein L14p/L23e; Region: Ribosomal_L14; cl00328 441952003667 Ribosomal protein S17; Region: Ribosomal_S17; cl00351 441952003668 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 441952003669 23S rRNA interface [nucleotide binding]; other site 441952003670 putative translocon interaction site; other site 441952003671 signal recognition particle (SRP54) interaction site; other site 441952003672 L23 interface [polypeptide binding]; other site 441952003673 trigger factor interaction site; other site 441952003674 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 441952003675 23S rRNA interface [nucleotide binding]; other site 441952003676 5S rRNA interface [nucleotide binding]; other site 441952003677 putative antibiotic binding site [chemical binding]; other site 441952003678 L25 interface [polypeptide binding]; other site 441952003679 L27 interface [polypeptide binding]; other site 441952003680 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 441952003681 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 441952003682 G-X-X-G motif; other site 441952003683 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 441952003684 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 441952003685 putative translocon binding site; other site 441952003686 protein-rRNA interface [nucleotide binding]; other site 441952003687 Ribosomal protein S19; Region: Ribosomal_S19; cl00350 441952003688 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 441952003689 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 441952003690 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 441952003691 Ribosomal protein L23; Region: Ribosomal_L23; cl00326 441952003692 Ribosomal protein L4/L1 family; Region: Ribosomal_L4; cl00325 441952003693 Ribosomal protein L3; Region: Ribosomal_L3; cl00324 441952003694 Ribosomal protein S10p/S20e; Region: Ribosomal_S10; cl00314 441952003695 elongation factor G; Reviewed; Region: PRK00007 441952003696 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 441952003697 G1 box; other site 441952003698 putative GEF interaction site [polypeptide binding]; other site 441952003699 GTP/Mg2+ binding site [chemical binding]; other site 441952003700 Switch I region; other site 441952003701 G2 box; other site 441952003702 G3 box; other site 441952003703 Switch II region; other site 441952003704 G4 box; other site 441952003705 G5 box; other site 441952003706 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 441952003707 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 441952003708 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 441952003709 Ribosomal protein S7p/S5e; Region: Ribosomal_S7; cl00313 441952003710 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 441952003711 S17 interaction site [polypeptide binding]; other site 441952003712 S8 interaction site; other site 441952003713 16S rRNA interaction site [nucleotide binding]; other site 441952003714 streptomycin interaction site [chemical binding]; other site 441952003715 23S rRNA interaction site [nucleotide binding]; other site 441952003716 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 441952003717 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 441952003718 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 441952003719 trimer interface [polypeptide binding]; other site 441952003720 active site 441952003721 Cytidylyltransferase family; Region: CTP_transf_1; cl00347 441952003722 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cl00230 441952003723 Putative undecaprenyl diphosphate synthase; Region: Prenyltransf; pfam01255 441952003724 catalytic residue [active] 441952003725 putative FPP diphosphate binding site; other site 441952003726 putative FPP binding hydrophobic cleft; other site 441952003727 dimer interface [polypeptide binding]; other site 441952003728 putative IPP diphosphate binding site; other site 441952003729 ribosome recycling factor; Reviewed; Region: frr; PRK00083 441952003730 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are 'recycled' and ready for another round of...; Region: RRF; cd00520 441952003731 hinge region; other site 441952003732 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 441952003733 putative nucleotide binding site [chemical binding]; other site 441952003734 uridine monophosphate binding site [chemical binding]; other site 441952003735 homohexameric interface [polypeptide binding]; other site 441952003736 elongation factor Ts; Provisional; Region: tsf; PRK09377 441952003737 Ubiquitin Associated domain. The UBA domain is a commonly occurring sequence motif in some members of the ubiquitination pathway, UV excision repair proteins, and certain protein kinases. Although its specific role is so far unknown, it has been...; Region: UBA; cl00153 441952003738 Elongation factor TS; Region: EF_TS; pfam00889 441952003739 Elongation factor TS; Region: EF_TS; pfam00889 441952003740 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 441952003741 rRNA interaction site [nucleotide binding]; other site 441952003742 S8 interaction site; other site 441952003743 putative laminin-1 binding site; other site 441952003744 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 441952003745 folate binding site [chemical binding]; other site 441952003746 NADP+ binding site [chemical binding]; other site 441952003747 Amidinotransferase; Region: Amidinotransf; cl12043 441952003748 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 441952003749 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 441952003750 HIGH motif; other site 441952003751 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 441952003752 active site 441952003753 KMSKS motif; other site 441952003754 fumarate hydratase; Reviewed; Region: fumC; PRK00485 441952003755 Class II fumarases; Region: Fumarase_classII; cd01362 441952003756 active site 441952003757 tetramer interface [polypeptide binding]; other site 441952003758 NAD(P)H:FMN oxidoreductase family. This domain catalyzes the reduction of flavin, nitrocompound, quinones and azo compounds using NADH or NADPH as an electron donor. The enzyme is a homodimer, and each monomer binds a FMN as co-factor. This family...; Region: NfsB_like_nitroreductase; cd02149 441952003759 dimer interface [polypeptide binding]; other site 441952003760 FMN binding site [chemical binding]; other site 441952003761 L-lactate dehydrogenase; Provisional; Region: lldD; PRK11197 441952003762 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl09108 441952003763 phosphate binding site [ion binding]; other site 441952003764 1-deoxy-D-xylulose-5-phosphate synthase; Region: PLN02225 441952003765 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 441952003766 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 441952003767 HIGH motif; other site 441952003768 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 441952003769 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 441952003770 active site 441952003771 KMSKS motif; other site 441952003772 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 441952003773 tRNA binding surface [nucleotide binding]; other site 441952003774 anticodon binding site; other site 441952003775 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 441952003776 DNA polymerase III chi subunit, HolC; Region: DNA_pol3_chi; cl01106 441952003777 Pyroglutamyl peptidase (PGP) type I, also known as pyrrolidone carboxyl peptidase (pcp) type I: Enzymes responsible for cleaving pyroglutamate (pGlu) from the N-terminal end of specialized proteins. The N-terminal pGlu protects these proteins from...; Region: Peptidase_C15; cd00501 441952003778 putative substrate binding pocket [chemical binding]; other site 441952003779 AC domain interface; other site 441952003780 catalytic triad [active] 441952003781 AB domain interface; other site 441952003782 interchain disulfide; other site 441952003783 Oxygen tolerance; Region: BatD; pfam13584 441952003784 Tetratricopeptide repeat; Region: TPR_16; pfam13432 441952003785 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 441952003786 hypothetical protein; Provisional; Region: PRK13685 441952003787 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 441952003788 metal ion-dependent adhesion site (MIDAS); other site 441952003789 VWA BatA type: Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b...; Region: vWA_BatA_type; cd01467 441952003790 metal ion-dependent adhesion site (MIDAS); other site 441952003791 Domain of unknown function (DUF4381); Region: DUF4381; pfam14316 441952003792 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 441952003793 MoxR-like ATPases [General function prediction only]; Region: COG0714 441952003794 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 441952003795 Protein of unknown function (DUF3568); Region: DUF3568; pfam12092 441952003796 pyridoxamine kinase; Validated; Region: PRK05756 441952003797 Pyridoxal kinase plays a key role in the synthesis of the active coenzyme pyridoxal-5'-phosphate (PLP), by catalyzing the phosphorylation of the precursor vitamin B6 in the presence of Zn2+ and ATP. Mammals are unable to synthesize PLP de novo and...; Region: pyridoxal_pyridoxamine_kinase; cd01173 441952003798 dimer interface [polypeptide binding]; other site 441952003799 pyridoxal binding site [chemical binding]; other site 441952003800 ATP binding site [chemical binding]; other site 441952003801 TIGR01210 family protein; Region: TIGR01210 441952003802 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Provisional; Region: lpxD; PRK00892 441952003803 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase, LpxD; Region: LpxD; pfam04613 441952003804 UDP-3-O-acyl-glucosamine N-acyltransferase (LpxD): The enzyme catalyzes the transfer of 3-hydroxymyristic acid or 3-hydroxy-arachidic acid, depending on the organism, from the acyl carrier protein (ACP) to UDP-3-O-acyl-glucosamine to produce UDP-2; Region: LbH_LpxD; cd03352 441952003805 trimer interface [polypeptide binding]; other site 441952003806 active site 441952003807 UDP-GlcNAc binding site [chemical binding]; other site 441952003808 lipid binding site [chemical binding]; lipid-binding site 441952003809 UbiA prenyltransferase family; Region: UbiA; cl00337 441952003810 Prokaryotic Cytochrome C oxidase subunit IV; Region: COX4_pro; cl01204 441952003811 Ubiquinol oxidase subunit III subfamily. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously...; Region: Ubiquinol_oxidase_III; cd02863 441952003812 Subunit I/III interface [polypeptide binding]; other site 441952003813 Subunit III/IV interface [polypeptide binding]; other site 441952003814 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 441952003815 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 441952003816 D-pathway; other site 441952003817 Putative ubiquinol binding site [chemical binding]; other site 441952003818 Low-spin heme (heme b) binding site [chemical binding]; other site 441952003819 Putative water exit pathway; other site 441952003820 Binuclear center (heme o3/CuB) [ion binding]; other site 441952003821 K-pathway; other site 441952003822 Putative proton exit pathway; other site 441952003823 cytochrome o ubiquinol oxidase subunit II; Region: CyoA; TIGR01433 441952003824 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; cl11412 441952003825 COX Aromatic Rich Motif; Region: COX_ARM; pfam06481 441952003826 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 441952003827 Major Facilitator Superfamily; Region: MFS_1; pfam07690 441952003828 putative substrate translocation pore; other site 441952003829 cytochrome d terminal oxidase subunit 1; Provisional; Region: PRK15097 441952003830 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; cl00562 441952003831 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 441952003832 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 441952003833 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 441952003834 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 441952003835 substrate binding pocket [chemical binding]; other site 441952003836 membrane-bound complex binding site; other site 441952003837 hinge residues; other site 441952003838 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 441952003839 This domain is the catalytic domain of ribonuclease II; Region: RNB; smart00955 441952003840 RNB domain; Region: RNB; pfam00773 441952003841 Phospholipase/Carboxylesterase; Region: Abhydrolase_2; pfam02230 441952003842 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 441952003843 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 441952003844 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cd00494 441952003845 domain interfaces; other site 441952003846 active site 441952003847 CrcB-like protein; Region: CRCB; cl09114 441952003848 Zinc-finger domain; Region: zf-CHCC; cl01821 441952003849 ABC-type anion transport system, duplicated permease component [Inorganic ion transport and metabolism]; Region: COG4986 441952003850 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 441952003851 dimer interface [polypeptide binding]; other site 441952003852 conserved gate region; other site 441952003853 putative PBP binding loops; other site 441952003854 ABC-ATPase subunit interface; other site 441952003855 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 441952003856 NrtD and SsuB are the ATP-binding subunits of the bacterial ABC-type nitrate and sulfonate transport systems, respectively. ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars; Region: ABC_NrtD_SsuB_transporters; cd03293 441952003857 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 441952003858 Walker A/P-loop; other site 441952003859 ATP binding site [chemical binding]; other site 441952003860 Q-loop/lid; other site 441952003861 ABC transporter signature motif; other site 441952003862 Walker B; other site 441952003863 D-loop; other site 441952003864 H-loop/switch region; other site 441952003865 ABC nitrate/sulfonate/bicarbonate family transporter, ATPase subunit; Region: ABC_transp; cl15413 441952003866 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 441952003867 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 441952003868 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 441952003869 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 441952003870 Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645 441952003871 trimer interface [polypeptide binding]; other site 441952003872 putative metal binding site [ion binding]; other site 441952003873 Outer membrane lipoprotein LolB; Region: LolB; pfam03550 441952003874 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: ipk; PRK00343 441952003875 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 441952003876 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859 441952003877 Phosphate transporter family; Region: PHO4; cl00396 441952003878 Phosphate transport regulator (distant homolog of PhoU) [Inorganic ion transport and metabolism]; Region: COG1392 441952003879 Phosphoesterase family; Region: Phosphoesterase; cl15450 441952003880 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 441952003881 Ligand Binding Site [chemical binding]; other site 441952003882 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 441952003883 Ligand Binding Site [chemical binding]; other site 441952003884 N-terminal putative catalytic domain of uncharacterized prokaryotic and archeal HKD family nucleases fused to a DEAD/DEAH box helicase domain; Region: PLDc_N_DEXD_b2; cd09204 441952003885 PLD-like domain; Region: PLDc_2; pfam13091 441952003886 putative homodimer interface [polypeptide binding]; other site 441952003887 putative active site [active] 441952003888 catalytic site [active] 441952003889 DEAD-like helicases superfamily; Region: DEXDc; smart00487 441952003890 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 441952003891 ATP binding site [chemical binding]; other site 441952003892 putative Mg++ binding site [ion binding]; other site 441952003893 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 441952003894 nucleotide binding region [chemical binding]; other site 441952003895 ATP-binding site [chemical binding]; other site 441952003896 Domain of unknown function (DUF3427); Region: DUF3427; pfam11907 441952003897 Alpha-tubulin suppressor and related RCC1 domain-containing proteins [Cell division and chromosome partitioning / Cytoskeleton]; Region: ATS1; COG5184 441952003898 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 441952003899 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 441952003900 Predicted hydrolase of the HAD superfamily [General function prediction only]; Region: COG2179 441952003901 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 441952003902 Predicted methyltransferases [General function prediction only]; Region: COG0313 441952003903 Precorrin-3B methylase [Coenzyme metabolism]; Region: CobJ; cl00304 441952003904 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 441952003905 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 441952003906 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 441952003907 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 441952003908 shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258 441952003909 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 441952003910 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 441952003911 shikimate binding site; other site 441952003912 NAD(P) binding site [chemical binding]; other site 441952003913 Ribosomal protein L34; Region: Ribosomal_L34; cl00370 441952003914 Ribonuclease P; Region: Ribonuclease_P; cl00457 441952003915 Haemolytic domain; Region: Haemolytic; cl00506 441952003916 membrane protein insertase; Provisional; Region: PRK01318 441952003917 60Kd inner membrane protein; Region: 60KD_IMP; cl00489 441952003918 Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279 441952003919 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 441952003920 putative acyl-acceptor binding pocket; other site 441952003921 Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279 441952003922 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 441952003923 putative acyl-acceptor binding pocket; other site 441952003924 elongation factor P; Validated; Region: PRK00529 441952003925 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 441952003926 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 441952003927 RNA binding site [nucleotide binding]; other site 441952003928 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 441952003929 RNA binding site [nucleotide binding]; other site 441952003930 DEDDh 3'-5' exonuclease domain of oligoribonuclease and similar proteins; Region: Orn; cd06135 441952003931 putative active site [active] 441952003932 putative substrate binding site [chemical binding]; other site 441952003933 catalytic site [active] 441952003934 dimer interface [polypeptide binding]; other site 441952003935 pyruvate phosphate dikinase; Provisional; Region: PRK09279 441952003936 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 441952003937 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 441952003938 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; cl01586 441952003939 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl09155 441952003940 Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879 441952003941 ferrous iron transport protein B; Reviewed; Region: feoB; PRK09554 441952003942 G1 box; other site 441952003943 GTP/Mg2+ binding site [chemical binding]; other site 441952003944 Switch I region; other site 441952003945 G2 box; other site 441952003946 G3 box; other site 441952003947 Switch II region; other site 441952003948 G4 box; other site 441952003949 G5 box; other site 441952003950 Nucleoside recognition; Region: Gate; cl00486 441952003951 Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664 441952003952 Nucleoside recognition; Region: Gate; cl00486 441952003953 primosome assembly protein PriA; Validated; Region: PRK05580 441952003954 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 441952003955 ATP binding site [chemical binding]; other site 441952003956 putative Mg++ binding site [ion binding]; other site 441952003957 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 441952003958 Nicotinamide mononucleotide transporter; Region: NMN_transporter; cl01256 441952003959 Virulence factor BrkB; Region: Virul_fac_BrkB; cl07918 441952003960 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 441952003961 Glycine zipper 2TM domain; Region: Rick_17kDa_Anti; cl10470 441952003962 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 441952003963 Major Facilitator Superfamily; Region: MFS_1; pfam07690 441952003964 putative substrate translocation pore; other site 441952003965 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 441952003966 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 441952003967 intersubunit interface [polypeptide binding]; other site 441952003968 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 441952003969 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 441952003970 Walker A/P-loop; other site 441952003971 ATP binding site [chemical binding]; other site 441952003972 Q-loop/lid; other site 441952003973 ABC transporter signature motif; other site 441952003974 Walker B; other site 441952003975 D-loop; other site 441952003976 H-loop/switch region; other site 441952003977 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 441952003978 dimer interface [polypeptide binding]; other site 441952003979 putative PBP binding regions; other site 441952003980 ABC-ATPase subunit interface; other site 441952003981 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 441952003982 active site 441952003983 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 441952003984 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 441952003985 GDP-binding site [chemical binding]; other site 441952003986 ACT binding site; other site 441952003987 IMP binding site; other site 441952003988 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 441952003989 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 441952003990 purine monophosphate binding site [chemical binding]; other site 441952003991 dimer interface [polypeptide binding]; other site 441952003992 putative catalytic residues [active] 441952003993 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 441952003994 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 441952003995 Lipocalin / cytosolic fatty-acid binding protein family; Region: Lipocalin; cl01150 441952003996 DNA polymerase III subunit delta; Reviewed; Region: holA; PRK05574 441952003997 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 441952003998 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 441952003999 glutamine synthetase; Region: PLN02284 441952004000 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 441952004001 Uncharacterized protein family, UPF0114; Region: UPF0114; cl01078 441952004002 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 441952004003 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 441952004004 dimer interface [polypeptide binding]; other site 441952004005 putative anticodon binding site; other site 441952004006 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 441952004007 motif 1; other site 441952004008 active site 441952004009 motif 2; other site 441952004010 motif 3; other site 441952004011 peptide chain release factor 2; Provisional; Region: PRK07342 441952004012 RF-1 domain; Region: RF-1; cl02875 441952004013 RF-1 domain; Region: RF-1; cl02875 441952004014 DNA polymerase III subunits gamma and tau; Provisional; Region: PRK14957 441952004015 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 441952004016 Walker A motif; other site 441952004017 ATP binding site [chemical binding]; other site 441952004018 Walker B motif; other site 441952004019 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 441952004020 arginine finger; other site 441952004021 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 441952004022 UDP-3-O-acyl-N-acetylglucosamine deacetylase [Cell envelope biogenesis, outer membrane]; Region: LpxC; cl00512 441952004023 UDP-3-O-acyl N-acetylglycosamine deacetylase; Region: LpxC; pfam03331 441952004024 cell division protein FtsZ; Validated; Region: PRK09330 441952004025 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 441952004026 nucleotide binding site [chemical binding]; other site 441952004027 SulA interaction site; other site 441952004028 cell division protein FtsA; Region: ftsA; TIGR01174 441952004029 Cell division protein FtsA; Region: FtsA; cl11496 441952004030 Cell division protein FtsA; Region: FtsA; cl11496 441952004031 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 441952004032 Cell division protein FtsQ; Region: FtsQ; pfam03799 441952004033 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 441952004034 nucleoside/Zn binding site; other site 441952004035 dimer interface [polypeptide binding]; other site 441952004036 catalytic motif [active] 441952004037 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06299 441952004038 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 441952004039 RNA binding site [nucleotide binding]; other site 441952004040 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 441952004041 RNA binding site [nucleotide binding]; other site 441952004042 S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists of...; Region: S1_RPS1_repeat_ec3; cd05688 441952004043 RNA binding site [nucleotide binding]; other site 441952004044 S1_RPS1_repeat_ec4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists of...; Region: S1_RPS1_repeat_ec4; cd05689 441952004045 RNA binding site [nucleotide binding]; other site 441952004046 S1_RPS1_repeat_ec5: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists of...; Region: S1_RPS1_repeat_ec5; cd05690 441952004047 RNA binding site [nucleotide binding]; other site 441952004048 S1_RPS1_repeat_ec6: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists of...; Region: S1_RPS1_repeat_ec6; cd05691 441952004049 RNA binding site [nucleotide binding]; other site 441952004050 Telomere recombination; Region: Sua5_yciO_yrdC; cl00305 441952004051 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 441952004052 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LCLAT1-like; Region: LPLAT_LCLAT1-like; cd07990 441952004053 putative acyl-acceptor binding pocket; other site 441952004054 RimK-like ATPgrasp N-terminal domain; Region: RLAN; pfam14401 441952004055 alpha-L-glutamate ligases, RimK family; Region: rimK_fam; TIGR00768 441952004056 ATP-grasp domain; Region: ATP-grasp_4; cl03087 441952004057 NrtD and SsuB are the ATP-binding subunits of the bacterial ABC-type nitrate and sulfonate transport systems, respectively. ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars; Region: ABC_NrtD_SsuB_transporters; cd03293 441952004058 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 441952004059 Walker A/P-loop; other site 441952004060 ATP binding site [chemical binding]; other site 441952004061 Q-loop/lid; other site 441952004062 ABC transporter signature motif; other site 441952004063 Walker B; other site 441952004064 D-loop; other site 441952004065 H-loop/switch region; other site 441952004066 YGGT family; Region: YGGT; cl00508 441952004067 YGGT family; Region: YGGT; cl00508 441952004068 phosphoribosylformylglycinamidine synthase; Provisional; Region: PRK05297 441952004069 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 441952004070 dimerization interface [polypeptide binding]; other site 441952004071 ATP binding site [chemical binding]; other site 441952004072 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 441952004073 dimerization interface [polypeptide binding]; other site 441952004074 ATP binding site [chemical binding]; other site 441952004075 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 441952004076 putative active site [active] 441952004077 catalytic triad [active] 441952004078 amidophosphoribosyltransferase; Provisional; Region: PRK09246 441952004079 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 441952004080 active site 441952004081 tetramer interface [polypeptide binding]; other site 441952004082 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 441952004083 active site 441952004084 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; cl00500 441952004085 type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844 441952004086 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 441952004087 Protein-L-isoaspartate carboxylmethyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: Pcm; COG2518 441952004088 putative protease; Provisional; Region: PRK15452 441952004089 Peptidase family U32; Region: Peptidase_U32; cl03113 441952004090 drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710 441952004091 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 441952004092 putative substrate translocation pore; other site 441952004093 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl15357 441952004094 transmembrane helices; other site 441952004095 Amino acid permease; Region: AA_permease_2; pfam13520 441952004096 Obg family GTPase CgtA; Region: Obg_CgtA; TIGR02729 441952004097 GTP1/OBG; Region: GTP1_OBG; pfam01018 441952004098 Obg GTPase; Region: Obg; cd01898 441952004099 G1 box; other site 441952004100 GTP/Mg2+ binding site [chemical binding]; other site 441952004101 Switch I region; other site 441952004102 G2 box; other site 441952004103 G3 box; other site 441952004104 Switch II region; other site 441952004105 G4 box; other site 441952004106 G5 box; other site 441952004107 Transmembrane amino acid transporter protein; Region: Aa_trans; cl15776 441952004108 aromatic amino acid transport protein; Region: araaP; TIGR00837 441952004109 Osmosensitive K+ channel histidine kinase [Signal transduction mechanisms]; Region: KdpD; COG2205 441952004110 Osmosensitive K+ channel His kinase sensor domain; Region: KdpD; pfam02702 441952004111 USP domain is located between the N-terminal sensor domain and C-terminal catalytic domain of this Osmosensitive K+ channel histidine kinase family. The family of KdpD sensor kinase proteins regulates the kdpFABC operon responsible for potassium...; Region: USP_OKCHK; cd01987 441952004112 Ligand Binding Site [chemical binding]; other site 441952004113 Domain of unknown function (DUF4118); Region: DUF4118; pfam13493 441952004114 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 441952004115 dimer interface [polypeptide binding]; other site 441952004116 phosphorylation site [posttranslational modification] 441952004117 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 441952004118 ATP binding site [chemical binding]; other site 441952004119 Mg2+ binding site [ion binding]; other site 441952004120 G-X-G motif; other site 441952004121 K+-transporting ATPase, c chain; Region: KdpC; cl00944 441952004122 potassium-transporting ATPase subunit B; Provisional; Region: PRK01122 441952004123 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 441952004124 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 441952004125 Potassium-transporting ATPase A subunit; Region: KdpA; cl00903 441952004126 RNA polymerase beta'' subunit; Reviewed; Region: rpoC2; CHL00117 441952004127 Type VI protein secretion system component VasK [Intracellular trafficking, secretion, and vesicular transport]; Region: IcmF; COG3523 441952004128 Domain of unknown function (DUF4280); Region: DUF4280; pfam14107 441952004129 Uncharacterized protein conserved in bacteria (DUF2077); Region: DUF2077; cl01370 441952004130 Intracellular growth locus C protein; Region: IglC; pfam11550 441952004131 Protein of unknown function (DUF877); Region: DUF877; pfam05943 441952004132 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3517; cl05484 441952004133 Protein of unknown function (DUF770); Region: DUF770; cl01402 441952004134 metabolite-proton symporter; Region: 2A0106; TIGR00883 441952004135 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 441952004136 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 441952004137 dimer interface [polypeptide binding]; other site 441952004138 anticodon binding site; other site 441952004139 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of the...; Region: AspRS_core; cd00777 441952004140 homodimer interface [polypeptide binding]; other site 441952004141 motif 1; other site 441952004142 active site 441952004143 motif 2; other site 441952004144 GAD domain; Region: GAD; pfam02938 441952004145 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it attaches...; Region: class_II_aaRS-like_core; cl00268 441952004146 active site 441952004147 motif 3; other site 441952004148 phosphate acetyltransferase; Reviewed; Region: PRK05632 441952004149 DRTGG domain; Region: DRTGG; cl12147 441952004150 Phosphate acetyl/butaryl transferase; Region: PTA_PTB; cl00390 441952004151 propionate/acetate kinase; Provisional; Region: PRK12379 441952004152 Acetokinase family; Region: Acetate_kinase; cl01029 441952004153 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 441952004154 dimer interface [polypeptide binding]; other site 441952004155 ssDNA binding site [nucleotide binding]; other site 441952004156 tetramer (dimer of dimers) interface [polypeptide binding]; other site 441952004157 RecX family; Region: RecX; cl00936 441952004158 recombinase A; Provisional; Region: recA; PRK09354 441952004159 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 441952004160 hexamer interface [polypeptide binding]; other site 441952004161 Walker A motif; other site 441952004162 ATP binding site [chemical binding]; other site 441952004163 Walker B motif; other site 441952004164 Preprotein translocase subunit SecB. SecB is a cytoplasmic component of the multisubunit membrane-bound enzyme termed Sec protein translocase, which is the main constituent of the General Secretory (type II) Pathway involved in translocation of nascent...; Region: Translocase_SecB; cl00251 441952004165 SecA binding site; other site 441952004166 Preprotein binding site; other site 441952004167 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 441952004168 Outer membrane protein (OmpH-like); Region: OmpH; smart00935 441952004169 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 441952004170 signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706 441952004171 tandem repeat interface [polypeptide binding]; other site 441952004172 oligomer interface [polypeptide binding]; other site 441952004173 active site residues [active] 441952004174 Pyruvate decarboxylase and related thiamine pyrophosphate-requiring enzymes [Carbohydrate transport and metabolism / Coenzyme metabolism / General function prediction only]; Region: COG3961 441952004175 Pyrimidine (PYR) binding domain of pyruvate decarboxylase (PDC), indolepyruvate decarboxylase (IPDC) and related proteins; Region: TPP_PYR_PDC_IPDC_like; cd07038 441952004176 dimer interface [polypeptide binding]; other site 441952004177 PYR/PP interface [polypeptide binding]; other site 441952004178 TPP binding site [chemical binding]; other site 441952004179 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; cl00815 441952004180 Thiamine pyrophosphate (TPP) family, PDC_IPDC subfamily, TPP-binding module; composed of proteins similar to pyruvate decarboxylase (PDC) and indolepyruvate decarboxylase (IPDC). PDC, a key enzyme in alcoholic fermentation, catalyzes the conversion of...; Region: TPP_PDC_IPDC; cd02005 441952004181 TPP-binding site [chemical binding]; other site 441952004182 dimer interface [polypeptide binding]; other site 441952004183 putative ABC transporter ATP-binding protein; Reviewed; Region: PRK11819 441952004184 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 441952004185 Walker A/P-loop; other site 441952004186 ATP binding site [chemical binding]; other site 441952004187 Q-loop/lid; other site 441952004188 ABC transporter signature motif; other site 441952004189 Walker B; other site 441952004190 D-loop; other site 441952004191 H-loop/switch region; other site 441952004192 ABC transporter; Region: ABC_tran_2; pfam12848 441952004193 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 441952004194 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 441952004195 metabolite-proton symporter; Region: 2A0106; TIGR00883 441952004196 putative substrate translocation pore; other site 441952004197 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 441952004198 chromosome replication initiation inhibitor protein; Validated; Region: PRK03635 441952004199 Helix-turn-helix domains; Region: HTH; cl00088 441952004200 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 441952004201 dimerization interface [polypeptide binding]; other site 441952004202 aminopeptidase N; Provisional; Region: pepN; PRK14015 441952004203 Peptidase M1 family containing Aminopeptidase N; Region: M1_APN_1; cd09600 441952004204 active site 441952004205 Zn binding site [ion binding]; other site 441952004206 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 441952004207 putative dimer interface [polypeptide binding]; other site 441952004208 bifunctional indole-3-glycerol phosphate synthase/phosphoribosylanthranilate isomerase; Provisional; Region: PRK09427 441952004209 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 441952004210 active site 441952004211 ribulose/triose binding site [chemical binding]; other site 441952004212 phosphate binding site [ion binding]; other site 441952004213 substrate (anthranilate) binding pocket [chemical binding]; other site 441952004214 product (indole) binding pocket [chemical binding]; other site 441952004215 Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are monomeric; Region: PRAI; cd00405 441952004216 active site 441952004217 GyrI-like small molecule binding domain; Region: GyrI-like; cl01368 441952004218 NHLP leader peptide domain; Region: TOMM_pelo; cl15464 441952004219 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 441952004220 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 441952004221 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 441952004222 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 441952004223 Glutamine amidotransferase class-I; Region: GATase; pfam00117 441952004224 glutamine binding [chemical binding]; other site 441952004225 catalytic triad [active] 441952004226 anthranilate synthase component I; Provisional; Region: PRK13564 441952004227 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 441952004228 chorismate binding enzyme; Region: Chorismate_bind; cl10555 441952004229 Helix-turn-helix domains; Region: HTH; cl00088 441952004230 ribonuclease G; Provisional; Region: PRK11712 441952004231 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 441952004232 homodimer interface [polypeptide binding]; other site 441952004233 oligonucleotide binding site [chemical binding]; other site