-- dump date   	20120504_144852
-- class       	Genbank::misc_feature
-- table       	misc_feature_note
-- id	note
326424000001	chromosomal replication initiation protein; Reviewed; Region: dnaA; PRK00149
326424000002	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
326424000003	Walker A motif; other site
326424000004	ATP binding site [chemical binding]; other site
326424000005	Walker B motif; other site
326424000006	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
326424000007	arginine finger; other site
326424000008	C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571
326424000009	DnaA box-binding interface [nucleotide binding]; other site
326424000010	DNA polymerase III subunit beta; Validated; Region: PRK07761
326424000011	Beta clamp domain.  The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria.  The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140
326424000012	putative DNA binding surface [nucleotide binding]; other site
326424000013	dimer interface [polypeptide binding]; other site
326424000014	beta-clamp/clamp loader binding surface; other site
326424000015	beta-clamp/translesion DNA polymerase binding surface; other site
326424000016	recombination protein F; Reviewed; Region: recF; PRK00064
326424000017	RecF is a recombinational DNA repair ATPase that maintains replication in the presence of DNA damage.  When replication is prematurely disrupted by DNA damage, several recF pathway gene products play critical roles processing the arrested replication...; Region: ABC_RecF; cd03242
326424000018	Walker A/P-loop; other site
326424000019	ATP binding site [chemical binding]; other site
326424000020	Q-loop/lid; other site
326424000021	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
326424000022	ABC transporter signature motif; other site
326424000023	Walker B; other site
326424000024	D-loop; other site
326424000025	H-loop/switch region; other site
326424000026	Protein of unknown function (DUF721); Region: DUF721; cl02324
326424000027	DNA gyrase subunit B; Validated; Region: gyrB; PRK05644
326424000028	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
326424000029	Mg2+ binding site [ion binding]; other site
326424000030	G-X-G motif; other site
326424000031	TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822
326424000032	anchoring element; other site
326424000033	dimer interface [polypeptide binding]; other site
326424000034	ATP binding site [chemical binding]; other site
326424000035	TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366
326424000036	active site
326424000037	putative metal-binding site [ion binding]; other site
326424000038	DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986
326424000039	DNA gyrase subunit A; Validated; Region: PRK05560
326424000040	DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes in DNA...; Region: TOP4c; cd00187
326424000041	CAP-like domain; other site
326424000042	active site
326424000043	primary dimer interface [polypeptide binding]; other site
326424000044	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
326424000045	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
326424000046	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
326424000047	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
326424000048	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
326424000049	Transmembrane domain of unknown function (DUF3566); Region: DUF3566; pfam12089
326424000050	RDD family; Region: RDD; cl00746
326424000051	Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487
326424000052	active site
326424000053	catalytic residues [active]
326424000054	metal binding site [ion binding]; metal-binding site
326424000055	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
326424000056	oligosaccharide amylase; Region: oligosac_amyl; TIGR01577
326424000057	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
326424000058	S-adenosylmethionine binding site [chemical binding]; other site
326424000059	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
326424000060	OsmC-like protein; Region: OsmC; cl00767
326424000061	Secretory lipase; Region: LIP; pfam03583
326424000062	SNARE associated Golgi protein; Region: SNARE_assoc; cl00429
326424000063	Nitrogen regulatory protein P-II; Region: P-II; cl00412
326424000064	Nitrogen regulatory protein P-II; Region: P-II; smart00938
326424000065	PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865
326424000066	substrate binding site [chemical binding]; other site
326424000067	AAA-like domain; Region: AAA_10; pfam12846
326424000068	Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600
326424000069	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic 'goose-type' lysozymes (GEWL).  LTs catalyze...; Region: LT_GEWL; cd00254
326424000070	N-acetyl-D-glucosamine binding site [chemical binding]; other site
326424000071	catalytic residue [active]
326424000072	NlpC/P60 family; Region: NLPC_P60; cl11438
326424000073	FAD binding domain; Region: FAD_binding_4; pfam01565
326424000074	FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277
326424000075	Berberine and berberine like; Region: BBE; pfam08031
326424000076	Catalytic domain of Protein Kinases; Region: PKc; cd00180
326424000077	active site
326424000078	ATP binding site [chemical binding]; other site
326424000079	substrate binding site [chemical binding]; other site
326424000080	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
326424000081	substrate binding site [chemical binding]; other site
326424000082	activation loop (A-loop); other site
326424000083	activation loop (A-loop); other site
326424000084	haloacid dehalogenase-like hydrolase family protein; Region: PLN02919
326424000085	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
326424000086	Catalytic domain of Protein Kinases; Region: PKc; cd00180
326424000087	active site
326424000088	ATP binding site [chemical binding]; other site
326424000089	substrate binding site [chemical binding]; other site
326424000090	activation loop (A-loop); other site
326424000091	haloacid dehalogenase-like hydrolase family protein; Region: PLN02919
326424000092	haloacid dehalogenase-like hydrolase family protein; Region: PLN02919
326424000093	NHL repeat; Region: NHL; pfam01436
326424000094	glucose-6-phosphate isomerase; Reviewed; Region: pgi; PRK00179
326424000095	Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015
326424000096	active site
326424000097	dimer interface [polypeptide binding]; other site
326424000098	Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016
326424000099	dimer interface [polypeptide binding]; other site
326424000100	active site
326424000101	Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043
326424000102	anti sigma factor interaction site; other site
326424000103	regulatory phosphorylation site [posttranslational modification]; other site
326424000104	zinc-ribbon domain; Region: zf-ribbon_3; cl11198
326424000105	cyclase homology domain; Region: CHD; cd07302
326424000106	nucleotidyl binding site; other site
326424000107	metal binding site [ion binding]; metal-binding site
326424000108	dimer interface [polypeptide binding]; other site
326424000109	Predicted ATPase [General function prediction only]; Region: COG3899
326424000110	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
326424000111	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
326424000112	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
326424000113	Walker A/P-loop; other site
326424000114	ATP binding site [chemical binding]; other site
326424000115	Q-loop/lid; other site
326424000116	ABC transporter signature motif; other site
326424000117	Walker B; other site
326424000118	D-loop; other site
326424000119	H-loop/switch region; other site
326424000120	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
326424000121	Helix-turn-helix domains; Region: HTH; cl00088
326424000122	Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer,  utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514
326424000123	FMN binding site [chemical binding]; other site
326424000124	dimer interface [polypeptide binding]; other site
326424000125	Major Facilitator Superfamily; Region: MFS_1; pfam07690
326424000126	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
326424000127	putative substrate translocation pore; other site
326424000128	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
326424000129	patatin-related protein; Region: TIGR03607
326424000130	Protein of unknown function (DUF3376); Region: DUF3376; pfam11856
326424000131	Acyl-CoA dehydrogenase N terminal; Region: AcylCoA_DH_N; pfam12418
326424000132	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
326424000133	active site
326424000134	Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806
326424000135	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
326424000136	E3 interaction surface; other site
326424000137	lipoyl attachment site [posttranslational modification]; other site
326424000138	e3 binding domain; Region: E3_binding; pfam02817
326424000139	dihydrolipoamide acetyltransferase; Provisional; Region: PRK14843
326424000140	2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; cl02008
326424000141	Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022
326424000142	Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036
326424000143	alpha subunit interface [polypeptide binding]; other site
326424000144	TPP binding site [chemical binding]; other site
326424000145	heterodimer interface [polypeptide binding]; other site
326424000146	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
326424000147	pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_x; TIGR03181
326424000148	Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000
326424000149	TPP-binding site [chemical binding]; other site
326424000150	tetramer interface [polypeptide binding]; other site
326424000151	heterodimer interface [polypeptide binding]; other site
326424000152	phosphorylation loop region [posttranslational modification]
326424000153	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
326424000154	F420-dependent oxidoreductase, MSMEG_4879 family; Region: F420_MSMEG_4879; TIGR03564
326424000155	Bacterial capsule synthesis protein PGA_cap; Region: PGA_cap; smart00854
326424000156	CapA and related proteins, metallophosphatase domain; Region: MPP_CapA; cd07381
326424000157	putative active site [active]
326424000158	putative metal binding site [ion binding]; other site
326424000159	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153
326424000160	metal binding site 2 [ion binding]; metal-binding site
326424000161	putative DNA binding helix; other site
326424000162	metal binding site 1 [ion binding]; metal-binding site
326424000163	dimer interface [polypeptide binding]; other site
326424000164	structural Zn2+ binding site [ion binding]; other site
326424000165	alanine aminotransferase; Validated; Region: PRK08363
326424000166	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
326424000167	pyridoxal 5'-phosphate binding site [chemical binding]; other site
326424000168	homodimer interface [polypeptide binding]; other site
326424000169	catalytic residue [active]
326424000170	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462
326424000171	ABC-ATPase subunit  interface; other site
326424000172	dimer interface [polypeptide binding]; other site
326424000173	putative PBP binding regions; other site
326424000174	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462
326424000175	ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121
326424000176	ABC component of the metal-type transporters.  This family includes transporters involved in the uptake of various metallic cations such as iron, manganese, and zinc.  The ATPases of this group of transporters are very similar to members of...; Region: ABC_Metallic_Cations; cd03235
326424000177	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
326424000178	ligand binding site [chemical binding]; other site
326424000179	Protein of unknown function (DUF2470); Region: DUF2470; pfam10615
326424000180	Uncharacterized protein conserved in bacteria (DUF2191); Region: DUF2191; cl02270
326424000181	Domain of unknown function (DUF222); Region: DUF222; pfam02720
326424000182	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
326424000183	active site
326424000184	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
326424000185	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
326424000186	active site
326424000187	phosphorylation site [posttranslational modification]
326424000188	intermolecular recognition site; other site
326424000189	dimerization interface [polypeptide binding]; other site
326424000190	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
326424000191	DNA binding residues [nucleotide binding]
326424000192	dimerization interface [polypeptide binding]; other site
326424000193	Reeler-like domain of YcnI and similar proteins; Region: YcnI_like; cd08545
326424000194	Bacterial Ig-like domain; Region: Big_5; cl01012
326424000195	Copper resistance protein D; Region: CopD; cl00563
326424000196	Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149
326424000197	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
326424000198	protein binding site [polypeptide binding]; other site
326424000199	large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567
326424000200	Large-conductance mechanosensitive channel, MscL; Region: MscL; cl00860
326424000201	Poly(3-hydroxybutyrate) depolymerase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: LpqC; COG3509
326424000202	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
326424000203	Deoxyribodipyrimidine photolyase [DNA replication, recombination, and repair]; Region: PhrB; COG0415
326424000204	DNA photolyase; Region: DNA_photolyase; pfam00875
326424000205	FAD binding domain of DNA photolyase; Region: FAD_binding_7; pfam03441
326424000206	Family 4 Uracil-DNA glycosylase (UDG), found exclusively in thermophilic organisms; Region: UDG_F4_TTUDGA_like; cd10030
326424000207	active site
326424000208	Fe-S cluster binding site [ion binding]; other site
326424000209	L,D-transpeptidase catalytic domain; Region: YkuD; cl15405
326424000210	pyridoxamine-phosphate oxidase; Region: pdxH; TIGR00558
326424000211	Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381
326424000212	Pyridoxine 5'-phosphate oxidase C-terminal dimerisation region; Region: PNPOx_C; pfam10590
326424000213	TIR domain; Region: TIR_2; cl15770
326424000214	Citrate synthase (CS), citryl-CoA lyase (CCL), the C-terminal portion of the single-subunit type ATP-citrate lyase (ACL) and the C-terminal portion of the large subunit of the two-subunit type ACL. CS catalyzes the condensation of acetyl coenzyme A; Region: CS_ACL-C_CCL; cl00416
326424000215	Citrate synthase; Region: Citrate_synt; pfam00285
326424000216	oxalacetate binding site [chemical binding]; other site
326424000217	citrylCoA binding site [chemical binding]; other site
326424000218	coenzyme A binding site [chemical binding]; other site
326424000219	catalytic triad [active]
326424000220	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
326424000221	Serine-pyruvate aminotransferase/archaeal aspartate aminotransferase [Amino acid transport and metabolism]; Region: COG0075
326424000222	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
326424000223	catalytic residue [active]
326424000224	Citrate synthase (CS), citryl-CoA lyase (CCL), the C-terminal portion of the single-subunit type ATP-citrate lyase (ACL) and the C-terminal portion of the large subunit of the two-subunit type ACL. CS catalyzes the condensation of acetyl coenzyme A; Region: CS_ACL-C_CCL; cl00416
326424000225	Citrate synthase; Region: Citrate_synt; pfam00285
326424000226	oxalacetate binding site [chemical binding]; other site
326424000227	citrylCoA binding site [chemical binding]; other site
326424000228	coenzyme A binding site [chemical binding]; other site
326424000229	catalytic triad [active]
326424000230	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
326424000231	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
326424000232	active site
326424000233	phosphorylation site [posttranslational modification]
326424000234	intermolecular recognition site; other site
326424000235	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
326424000236	DNA binding residues [nucleotide binding]
326424000237	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585
326424000238	Helix-turn-helix domains; Region: HTH; cl00088
326424000239	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
326424000240	Clp amino terminal domain; Region: Clp_N; pfam02861
326424000241	LigT like Phosphoesterase; Region: LigT_PEase; pfam02834
326424000242	2'-5' RNA ligase; Region: 2_5_ligase; TIGR02258
326424000243	Helix-turn-helix domains; Region: HTH; cl00088
326424000244	Sulfotransferase domain; Region: Sulfotransfer_1; pfam00685
326424000245	Chitin binding domain; Region: Chitin_bind_3; cl03871
326424000246	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075
326424000247	uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083
326424000248	Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; cl00986
326424000249	amidophosphoribosyltransferase; Provisional; Region: PRK07847
326424000250	Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of  glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715
326424000251	active site
326424000252	tetramer interface [polypeptide binding]; other site
326424000253	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
326424000254	active site
326424000255	phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385
326424000256	PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196
326424000257	dimerization interface [polypeptide binding]; other site
326424000258	putative ATP binding site [chemical binding]; other site
326424000259	Protein of unknown function (DUF3073); Region: DUF3073; pfam11273
326424000260	Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812
326424000261	Glutamate/Leucine/Phenylalanine/Valine dehydrogenase; Region: ELFV_dehydrog; pfam00208
326424000262	NAD(P) binding domain of leucine dehydrogenase, phenylalanine dehydrogenase, and valine dehydrogenase; Region: NAD_bind_Leu_Phe_Val_DH; cd01075
326424000263	NAD binding site [chemical binding]; other site
326424000264	Phe binding site; other site
326424000265	Helix-Turn-Helix DNA binding domain of truncated MerR-like proteins; Region: HTH_MerR-trunc; cd04762
326424000266	DNA binding residues [nucleotide binding]
326424000267	Protein of unknown function, DUF488; Region: DUF488; cl01246
326424000268	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761
326424000269	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
326424000270	dimer interface [polypeptide binding]; other site
326424000271	conserved gate region; other site
326424000272	putative PBP binding loops; other site
326424000273	ABC-ATPase subunit interface; other site
326424000274	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
326424000275	ABC transporter signature motif; other site
326424000276	Walker B; other site
326424000277	D-loop; other site
326424000278	H-loop/switch region; other site
326424000279	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761
326424000280	S-adenosyl methyltransferase; Region: Methyltransf_19; pfam04672
326424000281	Leucine carboxyl methyltransferase; Region: LCM; cl01306
326424000282	ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715
326424000283	S-adenosyl methyltransferase; Region: Methyltransf_19; pfam04672
326424000284	Leucine carboxyl methyltransferase; Region: LCM; cl01306
326424000285	RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
326424000286	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
326424000287	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761
326424000288	Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350
326424000289	The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445
326424000290	DNA binding site [nucleotide binding]
326424000291	active site
326424000292	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
326424000293	3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830
326424000294	Bacterial NAD-glutamate dehydrogenase; Region: Bac_GDH; pfam05088
326424000295	Protein of unknown function DUF72; Region: DUF72; cl00777
326424000296	The Class III extradiol dioxygenase, 4,5-DOPA Dioxygenase, catalyzes the incorporation of both atoms of molecular oxygen into 4,5-dihydroxy-phenylalanine; Region: 45_DOPA_Dioxygenase; cd07363
326424000297	putative active site [active]
326424000298	metal binding site [ion binding]; metal-binding site
326424000299	MatE; Region: MatE; cl10513
326424000300	Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+.  Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262
326424000301	Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297
326424000302	intersubunit interface [polypeptide binding]; other site
326424000303	Porphyromonas-type peptidyl-arginine deiminase; Region: PAD_porph; cl01113
326424000304	agmatine deiminase; Region: agmatine_aguA; TIGR03380
326424000305	Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cl11424
326424000306	active site
326424000307	catalytic triad [active]
326424000308	dimer interface [polypeptide binding]; other site
326424000309	Dyp-type peroxidase family; Region: Dyp_perox; cl01067
326424000310	Catalytic domain of Arabidopsis thaliana PI-PLC X domain-containing protein At5g67130 and its uncharacterized homologs; Region: PI-PLCc_At5g67130_like; cd08588
326424000311	putative active site [active]
326424000312	catalytic site [active]
326424000313	Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_2; cd07819
326424000314	putative hydrophobic ligand binding site [chemical binding]; other site
326424000315	B12-dependent methionine synthase; Provisional; Region: metH; PRK09490
326424000316	Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; cl14105
326424000317	MeTr subgroup of pterin binding enzymes. This family includes cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH).  Cobalamin-dependent...; Region: MeTr; cd00740
326424000318	substrate binding pocket [chemical binding]; other site
326424000319	B12 binding domain of methionine synthase. This domain binds methylcobalamin, which it uses as an intermediate methyl carrier from methyltetrahydrofolate (CH3H4folate) to homocysteine (Hcy); Region: methionine_synthase_B12_BD; cd02069
326424000320	B12 binding site [chemical binding]; other site
326424000321	cobalt ligand [ion binding]; other site
326424000322	Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965
326424000323	Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP; cl11399
326424000324	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
326424000325	Helix-turn-helix domains; Region: HTH; cl00088
326424000326	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
326424000327	Major Facilitator Superfamily; Region: MFS_1; pfam07690
326424000328	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
326424000329	Transcriptional regulators [Transcription]; Region: FadR; COG2186
326424000330	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
326424000331	DNA-binding site [nucleotide binding]; DNA binding site
326424000332	FCD domain; Region: FCD; cl11656
326424000333	Transcriptional regulators [Transcription]; Region: FadR; COG2186
326424000334	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
326424000335	DNA-binding site [nucleotide binding]; DNA binding site
326424000336	FCD domain; Region: FCD; cl11656
326424000337	alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289
326424000338	putative NAD(P) binding site [chemical binding]; other site
326424000339	enoyl-CoA hydratase; Provisional; Region: PRK06495
326424000340	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
326424000341	substrate binding site [chemical binding]; other site
326424000342	oxyanion hole (OAH) forming residues; other site
326424000343	trimer interface [polypeptide binding]; other site
326424000344	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
326424000345	CoenzymeA binding site [chemical binding]; other site
326424000346	subunit interaction site [polypeptide binding]; other site
326424000347	PHB binding site; other site
326424000348	Old yellow enzyme (OYE) YqjM-like FMN binding domain. YqjM is involved in the oxidative stress response of Bacillus subtilis.  Like the other OYE members, each monomer of YqjM contains FMN as a non-covalently bound cofactor and uses NADPH as a reducing...; Region: OYE_YqiM_FMN; cd02932
326424000349	active site
326424000350	FMN binding site [chemical binding]; other site
326424000351	substrate binding site [chemical binding]; other site
326424000352	homotetramer interface [polypeptide binding]; other site
326424000353	catalytic residue [active]
326424000354	Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109
326424000355	Helix-turn-helix domains; Region: HTH; cl00088
326424000356	cyclohexanecarboxylate-CoA ligase; Reviewed; Region: PRK13295
326424000357	AMP-binding enzyme; Region: AMP-binding; cl15778
326424000358	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
326424000359	Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2  has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829
326424000360	active site
326424000361	Rubredoxin-like zinc ribbon domain (DUF35_N); Region: DUF35_N; pfam12172
326424000362	DUF35 OB-fold domain; Region: DUF35; pfam01796
326424000363	short chain dehydrogenase; Provisional; Region: PRK08251
326424000364	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
326424000365	NAD(P) binding site [chemical binding]; other site
326424000366	active site
326424000367	enoyl-CoA hydratase; Provisional; Region: PRK09076
326424000368	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
326424000369	substrate binding site [chemical binding]; other site
326424000370	oxyanion hole (OAH) forming residues; other site
326424000371	trimer interface [polypeptide binding]; other site
326424000372	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
326424000373	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
326424000374	NAD(P) binding site [chemical binding]; other site
326424000375	active site
326424000376	Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518
326424000377	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
326424000378	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
326424000379	active site
326424000380	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
326424000381	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
326424000382	active site
326424000383	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
326424000384	Predicted ATPase [General function prediction only]; Region: COG3903
326424000385	ATP-dependent transcriptional regulator [Transcription]; Region: MalT; COG2909
326424000386	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
326424000387	DNA binding residues [nucleotide binding]
326424000388	dimerization interface [polypeptide binding]; other site
326424000389	oxidoreductase, Rxyl_3153 family; Region: Rxyl_3153; TIGR03989
326424000390	Class III alcohol dehydrogenase; Region: Zn_ADH_class_III; cd08279
326424000391	NAD binding site [chemical binding]; other site
326424000392	catalytic Zn binding site [ion binding]; other site
326424000393	substrate binding site [chemical binding]; other site
326424000394	structural Zn binding site [ion binding]; other site
326424000395	NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961
326424000396	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
326424000397	NAD(P) binding site [chemical binding]; other site
326424000398	catalytic residues [active]
326424000399	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; cl12078
326424000400	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
326424000401	ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129
326424000402	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
326424000403	Walker A/P-loop; other site
326424000404	ATP binding site [chemical binding]; other site
326424000405	Q-loop/lid; other site
326424000406	ABC transporter signature motif; other site
326424000407	Walker B; other site
326424000408	D-loop; other site
326424000409	H-loop/switch region; other site
326424000410	This family represents domain II of the carbohydrate uptake proteins that transport only monosaccharides (Monos).  The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and hexoses; Region: ABC_Carb_Monos_II; cd03215
326424000411	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
326424000412	TM-ABC transporter signature motif; other site
326424000413	PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812
326424000414	Antidote-toxin recognition MazE; Region: Antitoxin-MazE; cl00877
326424000415	Uncharacterized protein family (UPF0150); Region: UPF0150; cl00691
326424000416	YcfA-like protein; Region: YcfA; cl00752
326424000417	Predicted site-specific integrase-resolvase [DNA replication, recombination, and repair]; Region: COG2452
326424000418	Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cl02788
326424000419	catalytic nucleophile [active]
326424000420	Domain of unknown function (DUF4407); Region: DUF4407; pfam14362
326424000421	4Fe-4S single cluster domain; Region: Fer4_12; pfam13353
326424000422	anaerobic ribonucleotide reductase-activating protein; Provisional; Region: nrdG; cl15804
326424000423	AAA domain; Region: AAA_22; pfam13401
326424000424	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
326424000425	Walker A motif; other site
326424000426	ATP binding site [chemical binding]; other site
326424000427	Walker B motif; other site
326424000428	arginine finger; other site
326424000429	stage V sporulation protein K; Region: spore_V_K; TIGR02881
326424000430	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
326424000431	Walker A motif; other site
326424000432	ATP binding site [chemical binding]; other site
326424000433	Walker B motif; other site
326424000434	arginine finger; other site
326424000435	stage V sporulation protein K; Region: spore_V_K; TIGR02881
326424000436	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
326424000437	Walker A motif; other site
326424000438	ATP binding site [chemical binding]; other site
326424000439	Walker B motif; other site
326424000440	arginine finger; other site
326424000441	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
326424000442	H-loop/switch region; other site
326424000443	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
326424000444	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
326424000445	Walker A/P-loop; other site
326424000446	ATP binding site [chemical binding]; other site
326424000447	Q-loop/lid; other site
326424000448	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
326424000449	Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141
326424000450	nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095
326424000451	active site
326424000452	FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860
326424000453	non-prolyl cis peptide bond; other site
326424000454	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
326424000455	Helix-turn-helix domains; Region: HTH; cl00088
326424000456	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
326424000457	alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859
326424000458	Helix-turn-helix domains; Region: HTH; cl00088
326424000459	NB-ARC domain; Region: NB-ARC; pfam00931
326424000460	Tetratricopeptide repeat; Region: TPR_12; pfam13424
326424000461	Tetratricopeptide repeat; Region: TPR_12; pfam13424
326424000462	Tetratricopeptide repeat; Region: TPR_12; pfam13424
326424000463	Tetratricopeptide repeat; Region: TPR_12; pfam13424
326424000464	MoxR-like ATPases [General function prediction only]; Region: COG0714
326424000465	DNA helicase, putative; Region: TIGR00376
326424000466	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
326424000467	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
326424000468	Family description; Region: UvrD_C_2; cl15862
326424000469	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
326424000470	ATP binding site [chemical binding]; other site
326424000471	putative Mg++ binding site [ion binding]; other site
326424000472	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
326424000473	nucleotide binding region [chemical binding]; other site
326424000474	ATP-binding site [chemical binding]; other site
326424000475	Domain of unknown function (DUF4333); Region: DUF4333; pfam14230
326424000476	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
326424000477	Bacterial EndoU nuclease; Region: EndoU_bacteria; pfam14436
326424000478	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
326424000479	non-specific DNA binding site [nucleotide binding]; other site
326424000480	salt bridge; other site
326424000481	sequence-specific DNA binding site [nucleotide binding]; other site
326424000482	HipA N-terminal domain; Region: Couple_hipA; cl11853
326424000483	HipA-like N-terminal domain; Region: HipA_N; pfam07805
326424000484	HipA-like C-terminal domain; Region: HipA_C; pfam07804
326424000485	Predicted type IV restriction endonuclease [Defense mechanisms]; Region: COG2810
326424000486	Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; cl14958
326424000487	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
326424000488	Domain of unknown function (DUF1998); Region: DUF1998; pfam09369
326424000489	Putative catalytic domain of uncharacterized phospholipase D-like proteins; Region: PLDc_unchar4; cd09132
326424000490	putative active site [active]
326424000491	putative catalytic site [active]
326424000492	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
326424000493	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
326424000494	Catalytic domain of Protein Kinases; Region: PKc; cd00180
326424000495	active site
326424000496	ATP binding site [chemical binding]; other site
326424000497	substrate binding site [chemical binding]; other site
326424000498	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
326424000499	substrate binding site [chemical binding]; other site
326424000500	activation loop (A-loop); other site
326424000501	activation loop (A-loop); other site
326424000502	Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210
326424000503	UvrD-like helicase C-terminal domain; Region: UvrD_C; pfam13361
326424000504	Putative GTPases (G3E family) [General function prediction only]; Region: COG0523
326424000505	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
326424000506	Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; cl08458
326424000507	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
326424000508	Walker A/P-loop; other site
326424000509	ATP binding site [chemical binding]; other site
326424000510	Q-loop/lid; other site
326424000511	The excision repair protein UvrA domain I; Nucleotide excision repair in eubacteria is a process that repairs DNA damage by the removal of a 12-13-mer oligonucleotide containing the lesion.  Recognition and cleavage of the damaged DNA is a multistep...; Region: ABC_UvrA_I; cd03270
326424000512	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
326424000513	Walker A/P-loop; other site
326424000514	ATP binding site [chemical binding]; other site
326424000515	Q-loop/lid; other site
326424000516	ABC transporter signature motif; other site
326424000517	Walker B; other site
326424000518	D-loop; other site
326424000519	H-loop/switch region; other site
326424000520	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
326424000521	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
326424000522	active site
326424000523	ATP binding site [chemical binding]; other site
326424000524	substrate binding site [chemical binding]; other site
326424000525	activation loop (A-loop); other site
326424000526	Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161
326424000527	putative sugar binding sites [chemical binding]; other site
326424000528	Q-X-W motif; other site
326424000529	Lignostilbene-alpha,beta-dioxygenase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3670
326424000530	Retinal pigment epithelial membrane protein; Region: RPE65; cl10080
326424000531	Survival protein SurE; Region: SurE; cl00448
326424000532	RNA repair, ligase-Pnkp-associating, region of Hen1; Region: Hen1_L; pfam12623
326424000533	3' terminal RNA ribose 2'-O-methyltransferase Hen1; Region: bacter_Hen1; TIGR04074
326424000534	polynucleotide kinase-phosphatase; Region: bacter_Pnkp; TIGR04075
326424000535	Bacillus subtilis PrpE and related proteins, metallophosphatase domain; Region: MPP_PrpE; cd07423
326424000536	active site
326424000537	metal binding site [ion binding]; metal-binding site
326424000538	Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338
326424000539	catalytic residues [active]
326424000540	catalytic nucleophile [active]
326424000541	Recombinase; Region: Recombinase; pfam07508
326424000542	Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408
326424000543	YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259
326424000544	putative active site [active]
326424000545	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
326424000546	DNA-binding site [nucleotide binding]; DNA binding site
326424000547	Transcriptional regulators [Transcription]; Region: PhnF; COG2188
326424000548	UTRA domain; Region: UTRA; cl01230
326424000549	Domain of unknown function (DUF222); Region: DUF222; pfam02720
326424000550	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
326424000551	active site
326424000552	threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK12305
326424000553	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; cl08469
326424000554	Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771
326424000555	active site
326424000556	dimer interface [polypeptide binding]; other site
326424000557	motif 1; other site
326424000558	motif 2; other site
326424000559	motif 3; other site
326424000560	HGTP anticodon binding domain, as found at the C-terminus of histidyl, glycyl, threonyl and prolyl tRNA synthetases, which are classified as a group of class II aminoacyl-tRNA synthetases (aaRS). In aaRSs, the anticodon binding domain is responsible for...; Region: HGTP_anticodon; cl00266
326424000561	anticodon binding site; other site
326424000562	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
326424000563	Radical SAM superfamily; Region: Radical_SAM; pfam04055
326424000564	FeS/SAM binding site; other site
326424000565	Domain of unknown function (DUF4008); Region: DUF4008; cl14869
326424000566	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
326424000567	2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy; cl15773
326424000568	B12 binding domain_like associated with radical SAM domain. This domain shows similarity with B12 (adenosylcobamide) binding domains found in several enzymes, such as glutamate mutase, methionine synthase and methylmalonyl-CoA mutase, but it lacks the...; Region: radical_SAM_B12_BD; cd02068
326424000569	Elongator protein 3, MiaB family, Radical SAM; Region: Elp3; smart00729
326424000570	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
326424000571	FeS/SAM binding site; other site
326424000572	Glutathione synthase/Ribosomal protein S6 modification enzyme (glutaminyl transferase) [Coenzyme metabolism / Translation, ribosomal structure and biogenesis]; Region: RimK; COG0189
326424000573	ATP-grasp domain; Region: ATP-grasp_4; cl03087
326424000574	hypothetical protein; Provisional; Region: PRK08317
326424000575	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
326424000576	DNA-binding transcriptional activator of the SARP family [Signal transduction mechanisms]; Region: DnrI; COG3629
326424000577	Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450
326424000578	Peroxiredoxin (PRX) family, 1-cys PRX subfamily; composed of PRXs containing only one conserved cysteine, which serves as the peroxidatic cysteine. They are homodimeric thiol-specific antioxidant (TSA) proteins that confer a protective role in cells by...; Region: PRX_1cys; cd03016
326424000579	dimer interface [polypeptide binding]; other site
326424000580	decamer (pentamer of dimers) interface [polypeptide binding]; other site
326424000581	catalytic triad [active]
326424000582	N-terminal domain of Fpg (formamidopyrimidine-DNA glycosylase, MutM)_Nei (endonuclease VIII) base-excision repair DNA glycosylases; Region: FpgNei_N; cl03119
326424000583	DNA binding site [nucleotide binding]
326424000584	putative catalytic residues [active]
326424000585	Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831
326424000586	Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827
326424000587	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
326424000588	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
326424000589	active site
326424000590	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
326424000591	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
326424000592	alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859
326424000593	Helix-turn-helix domains; Region: HTH; cl00088
326424000594	Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type e : enzyme
326424000595	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
326424000596	Helix-turn-helix domains; Region: HTH; cl00088
326424000597	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
326424000598	Rhodococcus ruber 6-oxolauric acid dehydrogenase-like and related proteins; Region: ALDH_CddD-AldA-like; cd07089
326424000599	NAD binding site [chemical binding]; other site
326424000600	catalytic residues [active]
326424000601	3-ketoacyl-(acyl-carrier-protein) reductase; Reviewed; Region: PRK12826
326424000602	classical (c) SDRs; Region: SDR_c; cd05233
326424000603	NAD(P) binding site [chemical binding]; other site
326424000604	active site
326424000605	Domain of unknown function (DUF222); Region: DUF222; pfam02720
326424000606	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
326424000607	active site
326424000608	Carboxylesterase type B [Lipid metabolism]; Region: PnbA; COG2272
326424000609	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
326424000610	substrate binding pocket [chemical binding]; other site
326424000611	catalytic triad [active]
326424000612	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
326424000613	classical (c) SDRs; Region: SDR_c; cd05233
326424000614	NAD(P) binding site [chemical binding]; other site
326424000615	active site
326424000616	3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565
326424000617	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
326424000618	NAD(P) binding site [chemical binding]; other site
326424000619	active site
326424000620	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
326424000621	dimerization interface [polypeptide binding]; other site
326424000622	putative DNA binding site [nucleotide binding]; other site
326424000623	putative Zn2+ binding site [ion binding]; other site
326424000624	3-hydroxy-acyl-CoA dehydrogenase; Validated; Region: PRK08268
326424000625	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410
326424000626	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
326424000627	Walker A/P-loop; other site
326424000628	ATP binding site [chemical binding]; other site
326424000629	Q-loop/lid; other site
326424000630	ABC transporter signature motif; other site
326424000631	Walker B; other site
326424000632	D-loop; other site
326424000633	H-loop/switch region; other site
326424000634	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
326424000635	Periplasmic binding protein; Region: Peripla_BP_6; pfam13458
326424000636	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
326424000637	TM-ABC transporter signature motif; other site
326424000638	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
326424000639	TM-ABC transporter signature motif; other site
326424000640	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411
326424000641	The Mj1267/LivG ABC transporter subfamily is involved in the transport of the hydrophobic amino acids leucine, isoleucine and valine.  MJ1267 is a branched-chain amino acid transporter with 29% similarity to both the LivF and LivG components of the E; Region: ABC_Mj1267_LivG_branched; cd03219
326424000642	Walker A/P-loop; other site
326424000643	ATP binding site [chemical binding]; other site
326424000644	Q-loop/lid; other site
326424000645	ABC transporter signature motif; other site
326424000646	Walker B; other site
326424000647	D-loop; other site
326424000648	H-loop/switch region; other site
326424000649	Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154
326424000650	Amidase; Region: Amidase; cl11426
326424000651	Helix-turn-helix domains; Region: HTH; cl00088
326424000652	Bacterial transcriptional activator domain; Region: BTAD; pfam03704
326424000653	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
326424000654	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
326424000655	DNA binding residues [nucleotide binding]
326424000656	dimerization interface [polypeptide binding]; other site
326424000657	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444
326424000658	The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE).  The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257
326424000659	Walker A/P-loop; other site
326424000660	ATP binding site [chemical binding]; other site
326424000661	Q-loop/lid; other site
326424000662	ABC transporter signature motif; other site
326424000663	Walker B; other site
326424000664	D-loop; other site
326424000665	H-loop/switch region; other site
326424000666	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
326424000667	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124
326424000668	The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE).  The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257
326424000669	Walker A/P-loop; other site
326424000670	ATP binding site [chemical binding]; other site
326424000671	Q-loop/lid; other site
326424000672	ABC transporter signature motif; other site
326424000673	Walker B; other site
326424000674	D-loop; other site
326424000675	H-loop/switch region; other site
326424000676	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
326424000677	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173
326424000678	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
326424000679	putative PBP binding loops; other site
326424000680	ABC-ATPase subunit interface; other site
326424000681	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
326424000682	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427
326424000683	The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_15; cd08492
326424000684	Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496
326424000685	drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711
326424000686	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
326424000687	Helix-turn-helix domains; Region: HTH; cl00088
326424000688	Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109
326424000689	Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109
326424000690	3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565
326424000691	classical (c) SDRs; Region: SDR_c; cd05233
326424000692	NAD(P) binding site [chemical binding]; other site
326424000693	active site
326424000694	Erythronolide synthase docking; Region: Docking; pfam08990
326424000695	polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833
326424000696	Beta-ketoacyl synthase; Region: PKS_KS; smart00825
326424000697	active site
326424000698	DNA polymerase III subunits gamma and tau; Validated; Region: PRK07764
326424000699	malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128
326424000700	Acyl transferase domain; Region: Acyl_transf_1; cl08282
326424000701	Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826
326424000702	beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 3, complex (x); Region: KR_3_FAS_SDR_x; cd08956
326424000703	putative NADP binding site [chemical binding]; other site
326424000704	active site
326424000705	Phosphopantetheine attachment site; Region: PP-binding; cl09936
326424000706	Thioesterase; Region: PKS_TE; smart00824
326424000707	Erythronolide synthase docking; Region: Docking; pfam08990
326424000708	polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833
326424000709	Beta-ketoacyl synthase; Region: PKS_KS; smart00825
326424000710	active site
326424000711	malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128
326424000712	Acyl transferase domain; Region: Acyl_transf_1; cl08282
326424000713	Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826
326424000714	beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 3, complex (x); Region: KR_3_FAS_SDR_x; cd08956
326424000715	putative NADP binding site [chemical binding]; other site
326424000716	active site
326424000717	Phosphopantetheine attachment site; Region: PP-binding; cl09936
326424000718	Beta-ketoacyl synthase; Region: PKS_KS; smart00825
326424000719	polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833
326424000720	active site
326424000721	malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128
326424000722	Acyl transferase domain; Region: Acyl_transf_1; cl08282
326424000723	Phosphopantetheine attachment site; Region: PP-binding; cl09936
326424000724	Erythronolide synthase docking; Region: Docking; pfam08990
326424000725	Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321
326424000726	polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833
326424000727	active site
326424000728	Acyl transferase domain; Region: Acyl_transf_1; cl08282
326424000729	Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826
326424000730	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
326424000731	beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 3, complex (x); Region: KR_3_FAS_SDR_x; cd08956
326424000732	putative NADP binding site [chemical binding]; other site
326424000733	active site
326424000734	Phosphopantetheine attachment site; Region: PP-binding; cl09936
326424000735	polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833
326424000736	Beta-ketoacyl synthase; Region: PKS_KS; smart00825
326424000737	active site
326424000738	malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128
326424000739	Acyl transferase domain; Region: Acyl_transf_1; cl08282
326424000740	ketoreductase (KR), subgroup 1, complex (x) SDRs; Region: KR_1_SDR_x; cd08952
326424000741	NADP binding site [chemical binding]; other site
326424000742	active site
326424000743	Phosphopantetheine attachment site; Region: PP-binding; cl09936
326424000744	polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833
326424000745	Beta-ketoacyl synthase; Region: PKS_KS; smart00825
326424000746	active site
326424000747	malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128
326424000748	Acyl transferase domain; Region: Acyl_transf_1; cl08282
326424000749	Phosphopantetheine attachment site; Region: PP-binding; cl09936
326424000750	polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833
326424000751	Beta-ketoacyl synthase; Region: PKS_KS; smart00825
326424000752	active site
326424000753	malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128
326424000754	Acyl transferase domain; Region: Acyl_transf_1; cl08282
326424000755	Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826
326424000756	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
326424000757	enoyl reductase of polyketide synthase; Region: enoyl_red; cd05195
326424000758	Enoylreductase; Region: PKS_ER; smart00829
326424000759	NAD(P) binding site [chemical binding]; other site
326424000760	beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 3, complex (x); Region: KR_3_FAS_SDR_x; cd08956
326424000761	putative NADP binding site [chemical binding]; other site
326424000762	active site
326424000763	Phosphopantetheine attachment site; Region: PP-binding; cl09936
326424000764	kelch-like protein; Provisional; Region: PHA03098
326424000765	Kelch motif; Region: Kelch_1; cl02701
326424000766	Kelch motif; Region: Kelch_1; cl02701
326424000767	ABC transporter transmembrane region; Region: ABC_membrane; cl00549
326424000768	ABC transporter; Region: ABC_tran; pfam00005
326424000769	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
326424000770	Q-loop/lid; other site
326424000771	ABC transporter signature motif; other site
326424000772	Walker B; other site
326424000773	D-loop; other site
326424000774	H-loop/switch region; other site
326424000775	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
326424000776	Major Facilitator Superfamily; Region: MFS_1; pfam07690
326424000777	putative substrate translocation pore; other site
326424000778	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
326424000779	Uncharacterized protein family (UPF0104); Region: UPF0104; cl04219
326424000780	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
326424000781	3-ketoacyl-(acyl-carrier-protein) reductase; Reviewed; Region: PRK12826
326424000782	classical (c) SDRs; Region: SDR_c; cd05233
326424000783	NAD(P) binding site [chemical binding]; other site
326424000784	active site
326424000785	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
326424000786	Helix-turn-helix domains; Region: HTH; cl00088
326424000787	nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095
326424000788	FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860
326424000789	active site
326424000790	non-prolyl cis peptide bond; other site
326424000791	TIGR03086 family protein; Region: TIGR03086
326424000792	uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083
326424000793	Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cl00120
326424000794	amidase; Provisional; Region: PRK06061
326424000795	Amidase; Region: Amidase; cl11426
326424000796	Mechanosensitive ion channel; Region: MS_channel; pfam00924
326424000797	Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455
326424000798	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
326424000799	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl15754
326424000800	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
326424000801	Coenzyme A binding pocket [chemical binding]; other site
326424000802	ribosomal-protein-alanine N-acetyltransferase; Provisional; Region: rimI; PRK09491
326424000803	Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247
326424000804	Transcriptional regulators [Transcription]; Region: GntR; COG1802
326424000805	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
326424000806	DNA-binding site [nucleotide binding]; DNA binding site
326424000807	FCD domain; Region: FCD; cl11656
326424000808	Sodium:solute symporter family; Region: SSF; cl00456
326424000809	Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518
326424000810	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
326424000811	active site
326424000812	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
326424000813	Acyl-CoA dehydrogenase; Region: ACAD; cd00567
326424000814	active site
326424000815	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
326424000816	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
326424000817	catalytic residue [active]
326424000818	propionyl-CoA synthetase; Provisional; Region: prpE; PRK10524
326424000819	Domain of unknown function (DUF3448); Region: DUF3448; pfam11930
326424000820	AMP-binding enzyme; Region: AMP-binding; cl15778
326424000821	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
326424000822	Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804
326424000823	CoA-transferase family III; Region: CoA_transf_3; pfam02515
326424000824	N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247
326424000825	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
326424000826	N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247
326424000827	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
326424000828	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
326424000829	Threonine aldolase [Amino acid transport and metabolism]; Region: GLY1; COG2008
326424000830	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
326424000831	catalytic residue [active]
326424000832	putative luciferase-like monooxygenase, FMN-dependent, CE1758 family; Region: LLM_CE1758_fam; TIGR04036
326424000833	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
326424000834	Helix-turn-helix domains; Region: HTH; cl00088
326424000835	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
326424000836	probable F420-dependent oxidoreductase, Rv3520c family; Region: F420_Rv3520c; TIGR03559
326424000837	Helix-turn-helix domains; Region: HTH; cl00088
326424000838	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
326424000839	putative substrate translocation pore; other site
326424000840	Type I periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type active transport systems that are predicted to be involved in transport of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_7; cd06341
326424000841	Periplasmic binding protein; Region: Peripla_BP_6; pfam13458
326424000842	putative ligand binding site [chemical binding]; other site
326424000843	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883
326424000844	nudix motif; other site
326424000845	ABC transporter transmembrane region; Region: ABC_membrane; cl00549
326424000846	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
326424000847	Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884
326424000848	Walker A/P-loop; other site
326424000849	ATP binding site [chemical binding]; other site
326424000850	Q-loop/lid; other site
326424000851	ABC transporter signature motif; other site
326424000852	Walker B; other site
326424000853	D-loop; other site
326424000854	H-loop/switch region; other site
326424000855	enoyl-CoA hydratase; Provisional; Region: PRK06688
326424000856	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
326424000857	substrate binding site [chemical binding]; other site
326424000858	oxyanion hole (OAH) forming residues; other site
326424000859	trimer interface [polypeptide binding]; other site
326424000860	NADH pyrophosphatase zinc ribbon domain; Region: zf-NADH-PPase; pfam09297
326424000861	NADH pyrophosphatase, a member of the Nudix hydrolase superfamily, catalyzes the cleavage of NADH into reduced nicotinamide mononucleotide (NMNH) and AMP. Like other members of the Nudix family, it requires a divalent cation, such as Mg2+ or Mn2+, for...; Region: NADH_pyrophosphatase; cd03429
326424000862	putative NADH binding site [chemical binding]; other site
326424000863	putative active site [active]
326424000864	nudix motif; other site
326424000865	putative metal binding site [ion binding]; other site
326424000866	S-adenosyl methyltransferase; Region: Methyltransf_19; pfam04672
326424000867	NIPSNAP; Region: NIPSNAP; pfam07978
326424000868	NIPSNAP; Region: NIPSNAP; pfam07978
326424000869	Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer,  utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cd02062
326424000870	FMN binding site [chemical binding]; other site
326424000871	dimer interface [polypeptide binding]; other site
326424000872	Helix-turn-helix domains; Region: HTH; cl00088
326424000873	Helix-turn-helix domains; Region: HTH; cl00088
326424000874	Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909
326424000875	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632
326424000876	Rubredoxin-like zinc ribbon domain (DUF35_N); Region: DUF35_N; pfam12172
326424000877	DUF35 OB-fold domain; Region: DUF35; pfam01796
326424000878	lipid-transfer protein; Provisional; Region: PRK07855
326424000879	Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2  has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829
326424000880	active site
326424000881	Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513
326424000882	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
326424000883	ATP binding site [chemical binding]; other site
326424000884	Mg++ binding site [ion binding]; other site
326424000885	motif III; other site
326424000886	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
326424000887	nucleotide binding region [chemical binding]; other site
326424000888	ATP-binding site [chemical binding]; other site
326424000889	DbpA RNA binding domain; Region: DbpA; pfam03880
326424000890	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
326424000891	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
326424000892	active site
326424000893	Protein of unknown function DUF72; Region: DUF72; cl00777
326424000894	Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638
326424000895	Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938
326424000896	iron-sulfur cluster [ion binding]; other site
326424000897	[2Fe-2S] cluster binding site [ion binding]; other site
326424000898	START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643
326424000899	hydrophobic ligand binding site; other site
326424000900	Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285
326424000901	nucleoside/Zn binding site; other site
326424000902	dimer interface [polypeptide binding]; other site
326424000903	catalytic motif [active]
326424000904	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
326424000905	Helix-turn-helix domains; Region: HTH; cl00088
326424000906	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
326424000907	classical (c) SDRs; Region: SDR_c; cd05233
326424000908	NAD(P) binding site [chemical binding]; other site
326424000909	active site
326424000910	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
326424000911	Helix-turn-helix domains; Region: HTH; cl00088
326424000912	atypical (a) SDRs, subgroup 7; Region: SDR_a7; cd05262
326424000913	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
326424000914	putative NAD(P) binding site [chemical binding]; other site
326424000915	Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409
326424000916	Catalytic domain of Protein Kinases; Region: PKc; cd00180
326424000917	active site
326424000918	ATP binding site [chemical binding]; other site
326424000919	substrate binding site [chemical binding]; other site
326424000920	activation loop (A-loop); other site
326424000921	haloacid dehalogenase-like hydrolase family protein; Region: PLN02919
326424000922	NHL repeat; Region: NHL; pfam01436
326424000923	Catalytic domain of Protein Kinases; Region: PKc; cd00180
326424000924	active site
326424000925	ATP binding site [chemical binding]; other site
326424000926	substrate binding site [chemical binding]; other site
326424000927	activation loop (A-loop); other site
326424000928	haloacid dehalogenase-like hydrolase family protein; Region: PLN02919
326424000929	NHL repeat; Region: NHL; pfam01436
326424000930	Catalytic domain of Protein Kinases; Region: PKc; cd00180
326424000931	active site
326424000932	ATP binding site [chemical binding]; other site
326424000933	substrate binding site [chemical binding]; other site
326424000934	activation loop (A-loop); other site
326424000935	haloacid dehalogenase-like hydrolase family protein; Region: PLN02919
326424000936	NHL repeat; Region: NHL; pfam01436
326424000937	NHL repeat; Region: NHL; pfam01436
326424000938	NHL repeat; Region: NHL; pfam01436
326424000939	DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595
326424000940	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
326424000941	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761
326424000942	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
326424000943	3-hydroxybutyrate dehydrogenase; Region: PHB_DH; TIGR01963
326424000944	NAD(P) binding site [chemical binding]; other site
326424000945	active site
326424000946	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
326424000947	Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243
326424000948	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
326424000949	molybdopterin cofactor binding site; other site
326424000950	Molybdopterin-Binding, C-terminal (MopB_CT) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum-...; Region: MopB_CT; cl09929
326424000951	molybdopterin cofactor binding site; other site
326424000952	ZIP Zinc transporter; Region: Zip; pfam02535
326424000953	Predicted divalent heavy-metal cations transporter [Inorganic ion transport and metabolism]; Region: COG0428; cl00437
326424000954	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
326424000955	DNA binding site [nucleotide binding]
326424000956	active site
326424000957	Int/Topo IB signature motif; other site
326424000958	ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192
326424000959	helicase Cas3; Provisional; Region: PRK09694
326424000960	CRISPR/Cas system-associated protein Cas3''; Region: Cas3''_I; cd09641
326424000961	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
326424000962	CRISPR/Cas system-associated protein Cse1; Region: Cse1_I-E; cl08044
326424000963	CRISPR/Cas system-associated protein Cse2; Region: Cse2_I-E; cd09731
326424000964	CRISPR/Cas system-associated RAMP superfamily protein Cas7; Region: Cas7_I-E; cl09608
326424000965	CRISPR-associated protein (Cas_Cas5); Region: Cas_Cas5d; pfam09704
326424000966	CRISPR/Cas system-associated RAMP superfamily protein Cas5; Region: Cas5_I; cd09693
326424000967	CRISPR/Cas system-associated RAMP superfamily protein Cas6e; Region: Cas6_I-E; cd09727
326424000968	CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-E; cd09719
326424000969	CRISPR/Cas system-associated protein Cas2; Region: Cas2_I-E; cd09755
326424000970	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464
326424000971	Transposase; Region: DDE_Tnp_ISL3; pfam01610
326424000972	NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961
326424000973	Transposase; Region: DDE_Tnp_ISL3; pfam01610
326424000974	TIR domain; Region: TIR_2; cl15770
326424000975	Tetratricopeptide repeat; Region: TPR_10; pfam13374
326424000976	Tetratricopeptide repeat; Region: TPR_10; pfam13374
326424000977	Tetratricopeptide repeat; Region: TPR_10; pfam13374
326424000978	Tetratricopeptide repeat; Region: TPR_10; pfam13374
326424000979	putative PEP-CTERM system TPR-repeat lipoprotein; Region: PEP_TPR_lipo; TIGR02917
326424000980	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
326424000981	binding surface
326424000982	TPR motif; other site
326424000983	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
326424000984	binding surface
326424000985	TPR motif; other site
326424000986	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
326424000987	binding surface
326424000988	TPR motif; other site
326424000989	Transposase, Mutator family; Region: Transposase_mut; pfam00872
326424000990	Integrase core domain; Region: rve; cl01316
326424000991	Integrase core domain; Region: rve_3; cl15866
326424000992	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
326424000993	N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357
326424000994	Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type e : enzyme
326424000995	Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type e : enzyme
326424000996	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
326424000997	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; cl12078
326424000998	Conserved hypothetical ATP binding protein; Region: ATP_bind_1; pfam03029
326424000999	Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882
326424001000	G1 box; other site
326424001001	GTP/Mg2+ binding site [chemical binding]; other site
326424001002	G2 box; other site
326424001003	Switch I region; other site
326424001004	G3 box; other site
326424001005	Switch II region; other site
326424001006	G5 box; other site
326424001007	Protein of unknown function (DUF742); Region: DUF742; pfam05331
326424001008	Roadblock/LC7 domain; Region: Robl_LC7; cl00886
326424001009	Osmosensitive K+ channel histidine kinase [Signal transduction mechanisms]; Region: KdpD; COG2205
326424001010	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
326424001011	ATP binding site [chemical binding]; other site
326424001012	Mg2+ binding site [ion binding]; other site
326424001013	G-X-G motif; other site
326424001014	Ribosomal protein S18; Region: Ribosomal_S18; cl00373
326424001015	Domain of unknown function (DUF4394); Region: DUF4394; pfam14339
326424001016	Transcriptional accessory protein [Transcription]; Region: Tex; COG2183
326424001017	Tex-like protein N-terminal domain; Region: Tex_N; pfam09371
326424001018	Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination.  HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD includes...; Region: RuvC_resolvase; cl00243
326424001019	S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685
326424001020	RNA binding site [nucleotide binding]; other site
326424001021	MEDS: MEthanogen/methylotroph, DcmR Sensory domain; Region: MEDS; pfam14417
326424001022	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075
326424001023	lysozyme_like domain.  This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222
326424001024	START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643
326424001025	Domain of unknown function (DUF4407); Region: DUF4407; pfam14362
326424001026	Protein of unknown function (DUF3618); Region: DUF3618; pfam12277
326424001027	Apolipoprotein A1/A4/E domain; Region: Apolipoprotein; pfam01442
326424001028	Protein of unknown function (DUF1469); Region: DUF1469; cl12095
326424001029	Virulence factor BrkB; Region: Virul_fac_BrkB; cl07918
326424001030	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
326424001031	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
326424001032	AIR synthase-related protein, MSMEG_0567 C-terminal family; Region: MSMEG_0567_Cter; TIGR04050
326424001033	AIR synthase related protein, N-terminal domain; Region: AIRS; pfam00586
326424001034	AIR (aminoimidazole ribonucleotide) synthase related protein. This family includes Hydrogen expression/formation protein HypE, AIR synthases, FGAM (formylglycinamidine ribonucleotide) synthase and Selenophosphate synthetase (SelD). The N-terminal domain...; Region: PurM-like; cl10019
326424001035	MSMEG_0572 family protein; Region: MSMEG_0572_fam; TIGR04044
326424001036	DegT/DnrJ/EryC1/StrS aminotransferase family; Region: DegT_DnrJ_EryC1; pfam01041
326424001037	3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616
326424001038	inhibitor-cofactor binding pocket; inhibition site
326424001039	pyridoxal 5'-phosphate binding site [chemical binding]; other site
326424001040	catalytic residue [active]
326424001041	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
326424001042	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
326424001043	NAD(P) binding site [chemical binding]; other site
326424001044	active site
326424001045	Monogalactosyldiacylglycerol (MGDG) synthase; Region: MGDG_synth; pfam06925
326424001046	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
326424001047	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447
326424001048	nudix motif; other site
326424001049	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447
326424001050	The band 7 domain of flotillin (reggie) like proteins. This group contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin.  Many of these band 7 domain-containing proteins are lipid raft-associated.  Individual proteins of this...; Region: Band_7; cl02525
326424001051	Domain of unknown function (DUF397); Region: DUF397; pfam04149
326424001052	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761
326424001053	Band_7_flotillin: a subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin.  These two proteins are lipid raft-associated.  Individual proteins of...; Region: Band_7_flotillin; cd03399
326424001054	transcriptional activator FtrA; Provisional; Region: ftrA; PRK09393
326424001055	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
326424001056	active site
326424001057	phosphorylation site [posttranslational modification]
326424001058	intermolecular recognition site; other site
326424001059	dimerization interface [polypeptide binding]; other site
326424001060	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
326424001061	dimerization interface [polypeptide binding]; other site
326424001062	DNA binding residues [nucleotide binding]
326424001063	Histidine kinase; Region: HisKA_3; pfam07730
326424001064	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
326424001065	ATP binding site [chemical binding]; other site
326424001066	Mg2+ binding site [ion binding]; other site
326424001067	G-X-G motif; other site
326424001068	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
326424001069	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
326424001070	hypothetical protein; Provisional; Region: PRK07588
326424001071	Helix-turn-helix domains; Region: HTH; cl00088
326424001072	Common central domain of tyrosinase; Region: Tyrosinase; pfam00264
326424001073	Domain of unknown function (DUF427); Region: DUF427; cl00998
326424001074	topology modulation protein; Reviewed; Region: PRK08118
326424001075	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
326424001076	proline iminopeptidase, Neisseria-type subfamily; Region: pro_imino_pep_1; TIGR01249
326424001077	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
326424001078	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
326424001079	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
326424001080	Coenzyme A binding pocket [chemical binding]; other site
326424001081	Helix-turn-helix domains; Region: HTH; cl00088
326424001082	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632
326424001083	active site
326424001084	metal binding site [ion binding]; metal-binding site
326424001085	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
326424001086	alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859
326424001087	Predicted transcriptional regulator [Transcription]; Region: COG2378
326424001088	Helix-turn-helix domains; Region: HTH; cl00088
326424001089	WYL domain; Region: WYL; cl14852
326424001090	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
326424001091	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
326424001092	NAD(P) binding site [chemical binding]; other site
326424001093	active site
326424001094	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761
326424001095	VWA YIEM type: Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b...; Region: VWA_YIEM_type; cd01462
326424001096	metal ion-dependent adhesion site (MIDAS); other site
326424001097	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
326424001098	SWIM zinc finger; Region: SWIM; cl15408
326424001099	Ferric reductase like transmembrane component; Region: Ferric_reduct; cl01043
326424001100	NAD(P) binding domain of  ferredoxin reductase-like proteins catalyze electron transfer between an NAD(P)-binding sub-domain of the alpha/beta class and a discrete (usually N-terminal) domain, which varies in orientation with respect to the NAD(P)...; Region: FNR_like_3; cd06198
326424001101	FAD binding pocket [chemical binding]; other site
326424001102	FAD binding motif [chemical binding]; other site
326424001103	phosphate binding motif [ion binding]; other site
326424001104	beta-alpha-beta structure motif; other site
326424001105	NAD binding pocket [chemical binding]; other site
326424001106	FMN-binding domain; Region: FMN_bind; cl01081
326424001107	ApbE family; Region: ApbE; cl00643
326424001108	PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812
326424001109	putative active site [active]
326424001110	Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; cl09153
326424001111	Helix-turn-helix domains; Region: HTH; cl00088
326424001112	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
326424001113	Epoxide hydrolase N terminus; Region: EHN; pfam06441
326424001114	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
326424001115	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
326424001116	Carboxylesterase family; Region: COesterase; pfam00135
326424001117	substrate binding pocket [chemical binding]; other site
326424001118	catalytic triad [active]
326424001119	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786
326424001120	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786
326424001121	minor groove reading motif; other site
326424001122	helix-hairpin-helix signature motif; other site
326424001123	H+ Antiporter protein; Region: 2A0121; TIGR00900
326424001124	PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812
326424001125	TIR domain; Region: TIR_2; cl15770
326424001126	DNA polymerase III subunits gamma and tau; Validated; Region: PRK07764
326424001127	F420-dependent oxidoreductase, MSMEG_4879 family; Region: F420_MSMEG_4879; TIGR03564
326424001128	N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097
326424001129	Helix-turn-helix domains; Region: HTH; cl00088
326424001130	Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109
326424001131	short chain dehydrogenase; Provisional; Region: PRK06138
326424001132	classical (c) SDRs; Region: SDR_c; cd05233
326424001133	NAD(P) binding site [chemical binding]; other site
326424001134	active site
326424001135	Cupin domain; Region: Cupin_2; cl09118
326424001136	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
326424001137	drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711
326424001138	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
326424001139	Helix-turn-helix domains; Region: HTH; cl00088
326424001140	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
326424001141	Catalytic domain of Protein Kinases; Region: PKc; cd00180
326424001142	active site
326424001143	ATP binding site [chemical binding]; other site
326424001144	substrate binding site [chemical binding]; other site
326424001145	activation loop (A-loop); other site
326424001146	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
326424001147	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
326424001148	S-adenosylmethionine binding site [chemical binding]; other site
326424001149	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
326424001150	putative substrate translocation pore; other site
326424001151	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
326424001152	Helix-turn-helix domains; Region: HTH; cl00088
326424001153	Helix-turn-helix domains; Region: HTH; cl00088
326424001154	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
326424001155	ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116
326424001156	Walker A/P-loop; other site
326424001157	ATP binding site [chemical binding]; other site
326424001158	Q-loop/lid; other site
326424001159	ABC transporter signature motif; other site
326424001160	Walker B; other site
326424001161	D-loop; other site
326424001162	H-loop/switch region; other site
326424001163	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
326424001164	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
326424001165	dimer interface [polypeptide binding]; other site
326424001166	conserved gate region; other site
326424001167	putative PBP binding loops; other site
326424001168	ABC-ATPase subunit interface; other site
326424001169	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl15306
326424001170	substrate binding pocket [chemical binding]; other site
326424001171	membrane-bound complex binding site; other site
326424001172	hinge residues; other site
326424001173	Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175
326424001174	Clavaminic acid synthetase (CAS) -like;  CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cl00184
326424001175	FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121
326424001176	Phosphoenolpyruvate carboxylase [Energy production and conversion]; Region: Ppc; COG2352
326424001177	Phosphoenolpyruvate carboxylase; Region: PEPcase; cl14656
326424001178	Peptidase family M48; Region: Peptidase_M48; cl12018
326424001179	Helix-turn-helix domains; Region: HTH; cl00088
326424001180	Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; cl00562
326424001181	DNA polymerase III subunits gamma and tau; Provisional; Region: PRK12323
326424001182	cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219
326424001183	Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322
326424001184	CAAX protease self-immunity; Region: Abi; cl00558
326424001185	CYTH-like (also known as triphosphate tunnel metalloenzyme (TTM)-like) Phosphatases; Region: CYTH-like_Pase; cd07374
326424001186	putative active site; other site
326424001187	putative metal binding residues [ion binding]; other site
326424001188	signature motif; other site
326424001189	putative triphosphate binding site [ion binding]; other site
326424001190	CHAD domain; Region: CHAD; cl10506
326424001191	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
326424001192	active site
326424001193	catalytic tetrad [active]
326424001194	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box protein; Region: CSP_CDS; cd04458
326424001195	DNA-binding site [nucleotide binding]; DNA binding site
326424001196	RNA-binding motif; other site
326424001197	aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874
326424001198	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
326424001199	Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; cl15856
326424001200	aspartate kinase; Reviewed; Region: PRK06635
326424001201	AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261
326424001202	putative nucleotide binding site [chemical binding]; other site
326424001203	putative catalytic residues [active]
326424001204	putative Mg ion binding site [ion binding]; other site
326424001205	putative aspartate binding site [chemical binding]; other site
326424001206	ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913
326424001207	putative allosteric regulatory site; other site
326424001208	ACT domains of the lysine-sensitive, aspartokinase (AK) isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AKii-LysC-BS-like_2; cd04936
326424001209	putative allosteric regulatory residue; other site
326424001210	Uncharacterized proteins involved in stress response, homologs of TerZ and putative cAMP-binding protein CABP1 [Signal transduction mechanisms]; Region: TerZ; COG2310
326424001211	Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974
326424001212	putative metal binding site [ion binding]; other site
326424001213	Cinnamyl alcohol dehydrogenases (CAD); Region: CAD2; cd08298
326424001214	zinc-binding alcohol dehydrogenase family protein; Region: adh_fam_2; TIGR02822
326424001215	putative NAD(P) binding site [chemical binding]; other site
326424001216	putative substrate binding site [chemical binding]; other site
326424001217	catalytic Zn binding site [ion binding]; other site
326424001218	structural Zn binding site [ion binding]; other site
326424001219	recombination protein RecR; Reviewed; Region: recR; PRK00076
326424001220	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786
326424001221	RecR protein; Region: RecR; pfam02132
326424001222	TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR.  RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025
326424001223	putative active site [active]
326424001224	putative metal-binding site [ion binding]; other site
326424001225	tetramer interface [polypeptide binding]; other site
326424001226	YbaB/EbfC DNA-binding family; Region: YbaB_DNA_bd; cl00494
326424001227	DNA polymerase III, subunit gamma and tau; Region: dnaX_nterm; TIGR02397
326424001228	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
326424001229	Walker A motif; other site
326424001230	ATP binding site [chemical binding]; other site
326424001231	Walker B motif; other site
326424001232	arginine finger; other site
326424001233	DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169
326424001234	DNA polymerase III subunits gamma and tau; Validated; Region: PRK07764
326424001235	DNA polymerase III subunits gamma and tau; Validated; Region: PRK07764
326424001236	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
326424001237	Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161
326424001238	Ricin-type beta-trefoil lectin domain; Region: Ricin_B_lectin; pfam00652
326424001239	putative sugar binding sites [chemical binding]; other site
326424001240	Q-X-W motif; other site
326424001241	S-adenosyl methyltransferase; Region: Methyltransf_19; pfam04672
326424001242	Immunity protein Imm1; Region: Imm1; pfam14430
326424001243	Major Facilitator Superfamily; Region: MFS_1; pfam07690
326424001244	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
326424001245	putative substrate translocation pore; other site
326424001246	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
326424001247	4Fe-4S single cluster domain; Region: Fer4_15; pfam13459
326424001248	Helix-turn-helix domains; Region: HTH; cl00088
326424001249	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
326424001250	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
326424001251	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
326424001252	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
326424001253	Helix-turn-helix domains; Region: HTH; cl00088
326424001254	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
326424001255	active site
326424001256	trehalose synthase; Region: treS_nterm; TIGR02456
326424001257	Alpha amylase catalytic domain found in Trehalose synthetase; Region: AmyAc_TreS; cd11334
326424001258	active site
326424001259	catalytic site [active]
326424001260	short chain dehydrogenase; Provisional; Region: PRK07109
326424001261	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
326424001262	NAD(P) binding site [chemical binding]; other site
326424001263	active site
326424001264	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009
326424001265	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761
326424001266	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
326424001267	N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357
326424001268	TIR domain; Region: TIR_2; cl15770
326424001269	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
326424001270	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567
326424001271	structural tetrad; other site
326424001272	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567
326424001273	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
326424001274	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
326424001275	catalytic residue [active]
326424001276	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
326424001277	NADH(P)-binding; Region: NAD_binding_10; pfam13460
326424001278	NAD(P) binding site [chemical binding]; other site
326424001279	active site
326424001280	Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285
326424001281	nucleoside/Zn binding site; other site
326424001282	dimer interface [polypeptide binding]; other site
326424001283	catalytic motif [active]
326424001284	putative tRNA adenosine deaminase-associated protein; Region: tRNA_deam_assoc; TIGR03941
326424001285	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
326424001286	Domain of unknown function (DUF1727); Region: DUF1727; pfam08353
326424001287	Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750
326424001288	catalytic triad [active]
326424001289	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
326424001290	NlpC/P60 family; Region: NLPC_P60; cl11438
326424001291	Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598
326424001292	magnesium/nickel/cobalt transporter CorA; Provisional; Region: PRK11085; cl00459
326424001293	Domain of unknown function (DUF4139); Region: DUF4139; pfam13598
326424001294	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
326424001295	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
326424001296	active site
326424001297	phosphorylation site [posttranslational modification]
326424001298	intermolecular recognition site; other site
326424001299	dimerization interface [polypeptide binding]; other site
326424001300	Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cl00120
326424001301	CHASE3 domain; Region: CHASE3; cl05000
326424001302	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054
326424001303	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
326424001304	dimer interface [polypeptide binding]; other site
326424001305	phosphorylation site [posttranslational modification]
326424001306	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
326424001307	ATP binding site [chemical binding]; other site
326424001308	Mg2+ binding site [ion binding]; other site
326424001309	G-X-G motif; other site
326424001310	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
326424001311	active site
326424001312	phosphorylation site [posttranslational modification]
326424001313	intermolecular recognition site; other site
326424001314	dimerization interface [polypeptide binding]; other site
326424001315	TIGR03085 family protein; Region: TIGR03085
326424001316	Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily requires a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_26; cd04685
326424001317	nudix motif; other site
326424001318	Glycosyl hydrolase family 26; Region: Glyco_hydro_26; cl09200
326424001319	Interferon-induced transmembrane protein; Region: CD225; pfam04505
326424001320	Interferon-induced transmembrane protein; Region: CD225; pfam04505
326424001321	Cytochrome b (N-terminus)/b6/petB:  Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859
326424001322	formate dehydrogenase, gamma subunit; Region: formate-DH-gamm; TIGR01583
326424001323	Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199
326424001324	Moco binding site; other site
326424001325	metal coordination site [ion binding]; other site
326424001326	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cl02542
326424001327	Interferon-induced transmembrane protein; Region: CD225; pfam04505
326424001328	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
326424001329	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
326424001330	Walker A/P-loop; other site
326424001331	ATP binding site [chemical binding]; other site
326424001332	Q-loop/lid; other site
326424001333	ABC transporter signature motif; other site
326424001334	Walker B; other site
326424001335	D-loop; other site
326424001336	H-loop/switch region; other site
326424001337	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
326424001338	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
326424001339	active site
326424001340	phosphorylation site [posttranslational modification]
326424001341	intermolecular recognition site; other site
326424001342	dimerization interface [polypeptide binding]; other site
326424001343	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
326424001344	DNA binding residues [nucleotide binding]
326424001345	dimerization interface [polypeptide binding]; other site
326424001346	Histidine kinase; Region: HisKA_3; pfam07730
326424001347	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075
326424001348	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
326424001349	active site
326424001350	Acyl ACP desaturase, ferritin-like diiron-binding domain; Region: Acyl_ACP_Desat; cd01050
326424001351	homodimer interface [polypeptide binding]; other site
326424001352	putative substrate binding pocket [chemical binding]; other site
326424001353	diiron center [ion binding]; other site
326424001354	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
326424001355	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
326424001356	active site
326424001357	phosphorylation site [posttranslational modification]
326424001358	intermolecular recognition site; other site
326424001359	dimerization interface [polypeptide binding]; other site
326424001360	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
326424001361	DNA binding site [nucleotide binding]
326424001362	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
326424001363	dimerization interface [polypeptide binding]; other site
326424001364	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
326424001365	dimer interface [polypeptide binding]; other site
326424001366	phosphorylation site [posttranslational modification]
326424001367	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
326424001368	ATP binding site [chemical binding]; other site
326424001369	Mg2+ binding site [ion binding]; other site
326424001370	G-X-G motif; other site
326424001371	Predicted transcriptional regulator [Transcription]; Region: COG2378
326424001372	Helix-turn-helix domains; Region: HTH; cl00088
326424001373	WYL domain; Region: WYL; cl14852
326424001374	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632
326424001375	Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; cl00986
326424001376	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
326424001377	Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174
326424001378	Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120
326424001379	Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174
326424001380	Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120
326424001381	Uncharacterized conserved protein [Function unknown]; Region: COG3268
326424001382	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
326424001383	pyruvate carboxylase; Reviewed; Region: PRK12999
326424001384	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
326424001385	ATP-grasp domain; Region: ATP-grasp_4; cl03087
326424001386	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; cl08365
326424001387	Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937
326424001388	active site
326424001389	catalytic residues [active]
326424001390	metal binding site [ion binding]; metal-binding site
326424001391	homodimer binding site [polypeptide binding]; other site
326424001392	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
326424001393	carboxyltransferase (CT) interaction site; other site
326424001394	biotinylation site [posttranslational modification]; other site
326424001395	dolichyl-phosphate beta-D-mannosyltransferase; Region: PLN02726
326424001396	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
326424001397	active site
326424001398	GtrA-like protein; Region: GtrA; cl00971
326424001399	Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl15769
326424001400	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054
326424001401	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
326424001402	dimer interface [polypeptide binding]; other site
326424001403	phosphorylation site [posttranslational modification]
326424001404	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
326424001405	ATP binding site [chemical binding]; other site
326424001406	Mg2+ binding site [ion binding]; other site
326424001407	G-X-G motif; other site
326424001408	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
326424001409	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
326424001410	active site
326424001411	phosphorylation site [posttranslational modification]
326424001412	intermolecular recognition site; other site
326424001413	dimerization interface [polypeptide binding]; other site
326424001414	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
326424001415	DNA binding site [nucleotide binding]
326424001416	Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dcm; COG0270
326424001417	Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315
326424001418	cofactor binding site; other site
326424001419	DNA binding site [nucleotide binding]
326424001420	substrate interaction site [chemical binding]; other site
326424001421	Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210
326424001422	UvrD-like helicase C-terminal domain; Region: UvrD_C; pfam13361
326424001423	Dienelactone hydrolase family; Region: DLH; pfam01738
326424001424	Molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: DnaK; COG0443
326424001425	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
326424001426	E3 interaction surface; other site
326424001427	lipoyl attachment site [posttranslational modification]; other site
326424001428	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200
326424001429	structural tetrad; other site
326424001430	PQQ-like domain; Region: PQQ_2; pfam13360
326424001431	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
326424001432	active site
326424001433	phosphorylation site [posttranslational modification]
326424001434	intermolecular recognition site; other site
326424001435	Helix-turn-helix domains; Region: HTH; cl00088
326424001436	DNA binding residues [nucleotide binding]
326424001437	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075
326424001438	Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531
326424001439	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057
326424001440	metal ion-dependent adhesion site (MIDAS); other site
326424001441	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
326424001442	N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357
326424001443	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
326424001444	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
326424001445	DoxX; Region: DoxX; cl00976
326424001446	Bacterial capsule synthesis protein PGA_cap; Region: PGA_cap; smart00854
326424001447	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
326424001448	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
326424001449	Helix-turn-helix domains; Region: HTH; cl00088
326424001450	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
326424001451	active site
326424001452	metal binding site [ion binding]; metal-binding site
326424001453	Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467
326424001454	iron-sulfur cluster [ion binding]; other site
326424001455	[2Fe-2S] cluster binding site [ion binding]; other site
326424001456	Protein of unknown function (DUF2795); Region: DUF2795; pfam11387
326424001457	Zinc ribbon domain; Region: CxxC_CxxC_SSSS; cl00993
326424001458	L-asparaginase II; Region: Asparaginase_II; cl01842
326424001459	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
326424001460	HSP70 interaction site [polypeptide binding]; other site
326424001461	CoA-transferase family III; Region: CoA_transf_3; pfam02515
326424001462	ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683
326424001463	Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342
326424001464	dimerization interface [polypeptide binding]; other site
326424001465	ligand binding site [chemical binding]; other site
326424001466	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
326424001467	TM-ABC transporter signature motif; other site
326424001468	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
326424001469	TM-ABC transporter signature motif; other site
326424001470	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411
326424001471	The Mj1267/LivG ABC transporter subfamily is involved in the transport of the hydrophobic amino acids leucine, isoleucine and valine.  MJ1267 is a branched-chain amino acid transporter with 29% similarity to both the LivF and LivG components of the E; Region: ABC_Mj1267_LivG_branched; cd03219
326424001472	Walker A/P-loop; other site
326424001473	ATP binding site [chemical binding]; other site
326424001474	Q-loop/lid; other site
326424001475	ABC transporter signature motif; other site
326424001476	Walker B; other site
326424001477	D-loop; other site
326424001478	H-loop/switch region; other site
326424001479	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410
326424001480	LivF (TM1139) is part of the LIV-I bacterial ABC-type two-component transport system that imports neutral, branched-chain amino acids.  The  E. coli branched-chain amino acid transporter comprises a heterodimer of ABC transporters (LivF and LivG), a...; Region: ABC_TM1139_LivF_branched; cd03224
326424001481	Walker A/P-loop; other site
326424001482	ATP binding site [chemical binding]; other site
326424001483	Q-loop/lid; other site
326424001484	ABC transporter signature motif; other site
326424001485	Walker B; other site
326424001486	D-loop; other site
326424001487	H-loop/switch region; other site
326424001488	Helix-turn-helix domains; Region: HTH; cl00088
326424001489	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
326424001490	FAD binding domain; Region: FAD_binding_4; pfam01565
326424001491	D-arabinono-1,4-lactone oxidase; Region: ALO; cl04370
326424001492	acyl-CoA ligase (AMP-forming), exosortase A-associated; Region: ligase_PEP_1; TIGR03098
326424001493	AMP-binding enzyme; Region: AMP-binding; cl15778
326424001494	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
326424001495	ATP binding site [chemical binding]; other site
326424001496	putative Mg++ binding site [ion binding]; other site
326424001497	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
326424001498	nucleotide binding region [chemical binding]; other site
326424001499	ATP-binding site [chemical binding]; other site
326424001500	ATP-dependent DNA helicase RecQ; Region: recQ; TIGR01389
326424001501	Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300
326424001502	classical (c) SDRs; Region: SDR_c; cd05233
326424001503	NAD(P) binding site [chemical binding]; other site
326424001504	active site
326424001505	Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141
326424001506	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
326424001507	Hypothetical patatin similar to Z1214 protein of Escherichia coli; Region: Pat_hypo_Ecoli_Z1214_like; cd07209
326424001508	active site
326424001509	nucleophile elbow; other site
326424001510	N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357
326424001511	putative acyl-acceptor binding pocket; other site
326424001512	Domain of unknown function (DUF222); Region: DUF222; pfam02720
326424001513	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
326424001514	active site
326424001515	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
326424001516	ligand binding site [chemical binding]; other site
326424001517	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
326424001518	S-adenosylmethionine binding site [chemical binding]; other site
326424001519	Transcriptional regulator [Transcription]; Region: IclR; COG1414
326424001520	Helix-turn-helix domains; Region: HTH; cl00088
326424001521	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
326424001522	Catalytic domain of Protein Kinases; Region: PKc; cd00180
326424001523	active site
326424001524	ATP binding site [chemical binding]; other site
326424001525	substrate binding site [chemical binding]; other site
326424001526	activation loop (A-loop); other site
326424001527	Protein kinase domain; Region: Pkinase; pfam00069
326424001528	Catalytic domain of Protein Kinases; Region: PKc; cd00180
326424001529	active site
326424001530	ATP binding site [chemical binding]; other site
326424001531	substrate binding site [chemical binding]; other site
326424001532	activation loop (A-loop); other site
326424001533	NMT1-like family; Region: NMT1_2; cl15260
326424001534	Thioesterase domains of type I polyketide synthases or non-ribosomal peptide synthetases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3319
326424001535	probable F420-dependent oxidoreductase, MSMEG_3544 family; Region: F420_MSMEG_3544; TIGR03854
326424001536	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
326424001537	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557
326424001538	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
326424001539	NAD(P) binding site [chemical binding]; other site
326424001540	active site
326424001541	3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830
326424001542	classical (c) SDRs; Region: SDR_c; cd05233
326424001543	NAD(P) binding site [chemical binding]; other site
326424001544	active site
326424001545	PAP2_like proteins, Aur1_like subfamily. Yeast Aur1p or Ipc1p is necessary for the addition of inositol phosphate to ceramide, an essential step in yeast sphingolipid synthesis, and is the target of several antifungal compounds such as aureobasidin; Region: PAP2_Aur1_like; cd03386
326424001546	active site
326424001547	Flavin containing amine oxidoreductase; Region: Amino_oxidase; pfam01593
326424001548	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
326424001549	PAS domain S-box; Region: sensory_box; TIGR00229
326424001550	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
326424001551	putative active site [active]
326424001552	heme pocket [chemical binding]; other site
326424001553	PAS domain S-box; Region: sensory_box; TIGR00229
326424001554	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
326424001555	putative active site [active]
326424001556	heme pocket [chemical binding]; other site
326424001557	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
326424001558	dimer interface [polypeptide binding]; other site
326424001559	phosphorylation site [posttranslational modification]
326424001560	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
326424001561	ATP binding site [chemical binding]; other site
326424001562	Mg2+ binding site [ion binding]; other site
326424001563	G-X-G motif; other site
326424001564	Response regulator receiver domain; Region: Response_reg; pfam00072
326424001565	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
326424001566	active site
326424001567	phosphorylation site [posttranslational modification]
326424001568	intermolecular recognition site; other site
326424001569	dimerization interface [polypeptide binding]; other site
326424001570	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
326424001571	Response regulator receiver domain; Region: Response_reg; pfam00072
326424001572	active site
326424001573	phosphorylation site [posttranslational modification]
326424001574	intermolecular recognition site; other site
326424001575	dimerization interface [polypeptide binding]; other site
326424001576	ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192
326424001577	substrate binding site [chemical binding]; other site
326424001578	ATP binding site [chemical binding]; other site
326424001579	PAS domain S-box; Region: sensory_box; TIGR00229
326424001580	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
326424001581	putative active site [active]
326424001582	heme pocket [chemical binding]; other site
326424001583	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
326424001584	metal binding site [ion binding]; metal-binding site
326424001585	active site
326424001586	I-site; other site
326424001587	PAS fold; Region: PAS; pfam00989
326424001588	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
326424001589	putative active site [active]
326424001590	heme pocket [chemical binding]; other site
326424001591	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
326424001592	metal binding site [ion binding]; metal-binding site
326424001593	active site
326424001594	I-site; other site
326424001595	isovaleryl CoA dehydrogenase; Provisional; Region: PRK11561
326424001596	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
326424001597	active site
326424001598	NADPH-dependent FMN reductase; Region: FMN_red; cl00438
326424001599	Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 3011794; Product type e : enzyme
326424001600	Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type e : enzyme
326424001601	Evidence 5 : No homology to any previously reported sequences
326424001602	cystathionine gamma-synthase; Provisional; Region: PRK07811
326424001603	CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614
326424001604	homodimer interface [polypeptide binding]; other site
326424001605	substrate-cofactor binding pocket; other site
326424001606	pyridoxal 5'-phosphate binding site [chemical binding]; other site
326424001607	catalytic residue [active]
326424001608	cystathionine beta-synthase; Region: cysta_beta; TIGR01137
326424001609	CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561
326424001610	dimer interface [polypeptide binding]; other site
326424001611	pyridoxal 5'-phosphate binding site [chemical binding]; other site
326424001612	catalytic residue [active]
326424001613	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the pyridoxal-phosphate (PALP) dependent enzyme domain upstream.   The vitamin B6 complex comprises pyridoxine, pyridoxal, and pyridoxamine, as well...; Region: CBS_pair_PALP_assoc2; cd04609
326424001614	hypothetical protein; Provisional; Region: PRK11770
326424001615	Domain of unknown function (DUF307); Region: DUF307; pfam03733
326424001616	Domain of unknown function (DUF307); Region: DUF307; pfam03733
326424001617	Ferritin-like domain; Region: Ferritin; pfam00210
326424001618	Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657
326424001619	dinuclear metal binding motif [ion binding]; other site
326424001620	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
326424001621	ABC transporter transmembrane region; Region: ABC_membrane; cl00549
326424001622	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
326424001623	Walker A/P-loop; other site
326424001624	ATP binding site [chemical binding]; other site
326424001625	Q-loop/lid; other site
326424001626	ABC transporter signature motif; other site
326424001627	Walker B; other site
326424001628	D-loop; other site
326424001629	H-loop/switch region; other site
326424001630	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
326424001631	ABC transporter transmembrane region; Region: ABC_membrane; cl00549
326424001632	Glucan exporter ATP-binding protein.  In A. tumefaciens cyclic beta-1, 2-glucan must be transported into the periplasmic space to exert its action as a virluence factor.  This subfamily belongs to the MRP-like family and is involved in drug, peptide, and...; Region: ABCC_Glucan_exporter_like; cd03254
326424001633	Walker A/P-loop; other site
326424001634	ATP binding site [chemical binding]; other site
326424001635	Q-loop/lid; other site
326424001636	ABC transporter signature motif; other site
326424001637	Walker B; other site
326424001638	D-loop; other site
326424001639	H-loop/switch region; other site
326424001640	Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; some contain an N-terminal GntR family winged HTH DNA-binding domain; Region: SRPBCC_CalC_Aha1-like_GntR-HTH; cd08893
326424001641	putative hydrophobic ligand binding site [chemical binding]; other site
326424001642	Activation domain of S53 peptidases; Region: Pro-peptidase_S53; cl07889
326424001643	Peptidase domain in the S53 family; Region: Peptidases_S53; cd04056
326424001644	active site
326424001645	catalytic triad [active]
326424001646	calcium binding site [ion binding]; other site
326424001647	Type I periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type active transport systems that are predicted to be involved in transport of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_7; cd06341
326424001648	putative ligand binding site [chemical binding]; other site
326424001649	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
326424001650	TM-ABC transporter signature motif; other site
326424001651	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
326424001652	TM-ABC transporter signature motif; other site
326424001653	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411
326424001654	The Mj1267/LivG ABC transporter subfamily is involved in the transport of the hydrophobic amino acids leucine, isoleucine and valine.  MJ1267 is a branched-chain amino acid transporter with 29% similarity to both the LivF and LivG components of the E; Region: ABC_Mj1267_LivG_branched; cd03219
326424001655	Walker A/P-loop; other site
326424001656	ATP binding site [chemical binding]; other site
326424001657	Q-loop/lid; other site
326424001658	ABC transporter signature motif; other site
326424001659	Walker B; other site
326424001660	D-loop; other site
326424001661	H-loop/switch region; other site
326424001662	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410
326424001663	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
326424001664	Walker A/P-loop; other site
326424001665	ATP binding site [chemical binding]; other site
326424001666	Q-loop/lid; other site
326424001667	ABC transporter signature motif; other site
326424001668	Walker B; other site
326424001669	D-loop; other site
326424001670	H-loop/switch region; other site
326424001671	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
326424001672	CESA_like is  the cellulose synthase superfamily; Region: CESA_like; cd06423
326424001673	DXD motif; other site
326424001674	OpgC protein; Region: OpgC_C; cl00792
326424001675	Acyltransferase family; Region: Acyl_transf_3; pfam01757
326424001676	O-Glycosyl hydrolase family 30; Region: Glyco_hydro_30; pfam02055
326424001677	thiamine biosynthesis protein ThiC; Provisional; Region: PRK09284
326424001678	ThiC-associated domain; Region: ThiC-associated; pfam13667
326424001679	ThiC family; Region: ThiC; cl08031
326424001680	TIR domain; Region: TIR_2; cl15770
326424001681	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761
326424001682	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
326424001683	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
326424001684	Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459
326424001685	catalytic residues [active]
326424001686	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
326424001687	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
326424001688	Walker A motif; other site
326424001689	ATP binding site [chemical binding]; other site
326424001690	Walker B motif; other site
326424001691	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
326424001692	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
326424001693	active site
326424001694	phosphorylation site [posttranslational modification]
326424001695	intermolecular recognition site; other site
326424001696	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
326424001697	dimerization interface [polypeptide binding]; other site
326424001698	DNA binding residues [nucleotide binding]
326424001699	Osmosensitive K+ channel histidine kinase [Signal transduction mechanisms]; Region: KdpD; COG2205
326424001700	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585
326424001701	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075
326424001702	Protein of unknown function, DUF462; Region: DUF462; cl01190
326424001703	PemK-like protein; Region: PemK; cl00995
326424001704	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
326424001705	Ligand Binding Site [chemical binding]; other site
326424001706	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cl11420
326424001707	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cl00062
326424001708	anaerobic ribonucleotide reductase-activating protein; Provisional; Region: nrdG; cl15804
326424001709	4Fe-4S single cluster domain; Region: Fer4_12; pfam13353
326424001710	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
326424001711	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
326424001712	Walker A motif; other site
326424001713	ATP binding site [chemical binding]; other site
326424001714	Walker B motif; other site
326424001715	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; cl11083
326424001716	Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971
326424001717	Catalytic domain of Protein Kinases; Region: PKc; cd00180
326424001718	active site
326424001719	ATP binding site [chemical binding]; other site
326424001720	substrate binding site [chemical binding]; other site
326424001721	activation loop (A-loop); other site
326424001722	Mpr1p, Pad1p N-terminal (MPN) domains; Region: MPN; cl13996
326424001723	Mpr1p, Pad1p N-terminal (MPN) domains; Region: MPN; cl13996
326424001724	Ubiquitin-conjugating enzyme E2, catalytic (UBCc) domain. This is part of the ubiquitin-mediated protein degradation pathway in which a thiol-ester linkage forms between a conserved cysteine and the C-terminus of ubiquitin and complexes with ubiquitin...; Region: UBCc; cl00154
326424001725	ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757
326424001726	ATP binding site [chemical binding]; other site
326424001727	substrate interface [chemical binding]; other site
326424001728	Ubiquitin-like proteins; Region: UBQ; cl00155
326424001729	RES domain; Region: RES; cl02411
326424001730	CHAT domain; Region: CHAT; cl02083
326424001731	CHAT domain; Region: CHAT; cl02083
326424001732	Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161
326424001733	Ricin-type beta-trefoil lectin domain; Region: Ricin_B_lectin; pfam00652
326424001734	putative sugar binding sites [chemical binding]; other site
326424001735	Q-X-W motif; other site
326424001736	Methyltransferase domain; Region: Methyltransf_31; pfam13847
326424001737	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
326424001738	S-adenosylmethionine binding site [chemical binding]; other site
326424001739	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
326424001740	Helix-turn-helix domains; Region: HTH; cl00088
326424001741	DsrE/DsrF-like family; Region: DrsE; cl00672
326424001742	Cupin domain; Region: Cupin_2; cl09118
326424001743	Phosphotransferase enzyme family; Region: APH; pfam01636
326424001744	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
326424001745	Helix-turn-helix domains; Region: HTH; cl00088
326424001746	2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy; cl15773
326424001747	ATP-grasp domain; Region: ATP-grasp_4; cl03087
326424001748	S-adenosyl methyltransferase; Region: Methyltransf_19; pfam04672
326424001749	Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971
326424001750	3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830
326424001751	classical (c) SDRs; Region: SDR_c; cd05233
326424001752	NAD(P) binding site [chemical binding]; other site
326424001753	active site
326424001754	enoyl-CoA hydratase; Provisional; Region: PRK06210
326424001755	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
326424001756	substrate binding site [chemical binding]; other site
326424001757	oxyanion hole (OAH) forming residues; other site
326424001758	trimer interface [polypeptide binding]; other site
326424001759	Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cl00161
326424001760	Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841
326424001761	active site
326424001762	metal binding site [ion binding]; metal-binding site
326424001763	homotetramer interface [polypeptide binding]; other site
326424001764	LysM domain/BON superfamily protein; Provisional; Region: PRK11198
326424001765	DNA polymerase III subunits gamma and tau; Provisional; Region: PRK12323
326424001766	type VII secretion protein EccCa; Region: T7SS_EccC_a; TIGR03924
326424001767	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
326424001768	type VII secretion protein EccCb; Region: T7SS_EccC_b; TIGR03925
326424001769	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
326424001770	RNase II stability modulator; Provisional; Region: PRK10060
326424001771	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
326424001772	metal binding site [ion binding]; metal-binding site
326424001773	active site
326424001774	I-site; other site
326424001775	Domain of unknown function (DUF305); Region: DUF305; cl15795
326424001776	Uncharacterized protein conserved in bacteria (DUF2255); Region: DUF2255; cl01788
326424001777	PII uridylyl-transferase; Provisional; Region: PRK03381
326424001778	GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335
326424001779	C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_ACR-UUR-like_2; cd04899
326424001780	Nitrogen regulatory protein P-II; Region: P-II; cl00412
326424001781	Nitrogen regulatory protein P-II; Region: P-II; smart00938
326424001782	Ammonium Transporter Family; Region: Ammonium_transp; cl03012
326424001783	NlpC/P60 family; Region: NLPC_P60; cl11438
326424001784	Helix-turn-helix domains; Region: HTH; cl00088
326424001785	Helix-turn-helix diphteria tox regulatory element; Region: HTH_DTXR; smart00529
326424001786	Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742
326424001787	Protein of unknown function (DUF3039); Region: DUF3039; pfam11238
326424001788	Malic enzyme [Energy production and conversion]; Region: SfcA; COG0281
326424001789	Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466
326424001790	active site
326424001791	trimer interface [polypeptide binding]; other site
326424001792	dimer interface [polypeptide binding]; other site
326424001793	DegT/DnrJ/EryC1/StrS aminotransferase family; Region: DegT_DnrJ_EryC1; pfam01041
326424001794	3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616
326424001795	inhibitor-cofactor binding pocket; inhibition site
326424001796	pyridoxal 5'-phosphate binding site [chemical binding]; other site
326424001797	catalytic residue [active]
326424001798	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
326424001799	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
326424001800	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; cl11611
326424001801	3-amino-5-hydroxybenoic acid synthesis related protein; Region: AHBA_synth_RP; TIGR01454
326424001802	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
326424001803	motif II; other site
326424001804	Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501
326424001805	NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065
326424001806	shikimate binding site; other site
326424001807	NAD(P) binding site [chemical binding]; other site
326424001808	Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195
326424001809	dimer interface [polypeptide binding]; other site
326424001810	active site
326424001811	metal binding site [ion binding]; metal-binding site
326424001812	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
326424001813	Helix-turn-helix domains; Region: HTH; cl00088
326424001814	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632
326424001815	active site
326424001816	metal binding site [ion binding]; metal-binding site
326424001817	Cupin domain; Region: Cupin_2; cl09118
326424001818	Cupin domain; Region: Cupin_2; cl09118
326424001819	Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726
326424001820	Dehydrogenases (flavoproteins) [Energy production and conversion]; Region: FixC; COG0644
326424001821	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
326424001822	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
326424001823	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076
326424001824	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
326424001825	selenocysteine synthase; Provisional; Region: PRK04311
326424001826	Predicted membrane protein [Function unknown]; Region: COG2119
326424001827	Uncharacterized protein family UPF0016; Region: UPF0016; pfam01169
326424001828	Uncharacterized protein family UPF0016; Region: UPF0016; pfam01169
326424001829	Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043
326424001830	anti sigma factor interaction site; other site
326424001831	regulatory phosphorylation site [posttranslational modification]; other site
326424001832	mycothiol synthase; Region: mycothiol_MshD; TIGR03448
326424001833	N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357
326424001834	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
326424001835	DNA binding site [nucleotide binding]
326424001836	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
326424001837	Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754
326424001838	MoaE interaction surface [polypeptide binding]; other site
326424001839	MoeB interaction surface [polypeptide binding]; other site
326424001840	thiocarboxylated glycine; other site
326424001841	Protein of unknown function (DUF2993); Region: DUF2993; pfam11209
326424001842	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
326424001843	catalytic residues [active]
326424001844	Domain of unknown function (DUF4395); Region: DUF4395; pfam14340
326424001845	Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448
326424001846	Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897
326424001847	active site residue [active]
326424001848	Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449
326424001849	active site residue [active]
326424001850	Protein of unknown function (DUF1416); Region: DUF1416; pfam07210
326424001851	DsrE/DsrF-like family; Region: DrsE; cl00672
326424001852	nitrobindin heme-binding domain; Region: nitrobindin; cd07828
326424001853	heme-binding site [chemical binding]; other site
326424001854	Putative bacterial sensory transduction regulator; Region: YbjN; cl15834
326424001855	UDP-N-acetylglucosamine: 1L-myo-inositol-1-phosphate 1-alpha-D-N-acetylglucosaminyltransferase; Region: mycothiol_MshA; TIGR03449
326424001856	This family is most closely related to the GT1 family of glycosyltransferases. The sucrose-phosphate synthases in this family may be unique to plants and photosynthetic bacteria. This enzyme catalyzes the synthesis of sucrose 6-phosphate from fructose...; Region: GT1_Sucrose_synthase; cd03800
326424001857	putative ADP-binding pocket [chemical binding]; other site
326424001858	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
326424001859	Macro domain, a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ADP-ribose polymerases). Some macro domains recognize poly...; Region: Macro; cl00019
326424001860	ADP-ribose binding site [chemical binding]; other site
326424001861	Protein of unknown function (DUF1269); Region: DUF1269; cl01978
326424001862	Predicted oxidoreductases (related to aryl-alcohol dehydrogenases) [Energy production and conversion]; Region: Tas; COG0667
326424001863	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
326424001864	active site
326424001865	catalytic tetrad [active]
326424001866	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
326424001867	non-specific DNA binding site [nucleotide binding]; other site
326424001868	salt bridge; other site
326424001869	sequence-specific DNA binding site [nucleotide binding]; other site
326424001870	Domain of Unknown Function (DUF349); Region: DUF349; pfam03993
326424001871	Domain of Unknown Function (DUF349); Region: DUF349; pfam03993
326424001872	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427
326424001873	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
326424001874	dimer interface [polypeptide binding]; other site
326424001875	conserved gate region; other site
326424001876	ABC-ATPase subunit interface; other site
326424001877	sulfate ABC transporter, ATP-binding protein; Region: 3a0106s01; TIGR00968
326424001878	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
326424001879	Walker A/P-loop; other site
326424001880	ATP binding site [chemical binding]; other site
326424001881	Q-loop/lid; other site
326424001882	ABC transporter signature motif; other site
326424001883	Walker B; other site
326424001884	D-loop; other site
326424001885	H-loop/switch region; other site
326424001886	Predicted aminomethyltransferase related to GcvT [General function prediction only]; Region: COG0354
326424001887	folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317
326424001888	Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669
326424001889	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
326424001890	catalytic core [active]
326424001891	Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP; cd07040
326424001892	phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135
326424001893	PhoU domain; Region: PhoU; pfam01895
326424001894	PhoU domain; Region: PhoU; pfam01895
326424001895	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
326424001896	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
326424001897	dimer interface [polypeptide binding]; other site
326424001898	phosphorylation site [posttranslational modification]
326424001899	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
326424001900	ATP binding site [chemical binding]; other site
326424001901	Mg2+ binding site [ion binding]; other site
326424001902	G-X-G motif; other site
326424001903	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
326424001904	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
326424001905	active site
326424001906	phosphorylation site [posttranslational modification]
326424001907	intermolecular recognition site; other site
326424001908	dimerization interface [polypeptide binding]; other site
326424001909	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
326424001910	DNA binding site [nucleotide binding]
326424001911	Ppx/GppA phosphatase family; Region: Ppx-GppA; cl15449
326424001912	AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060
326424001913	Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261
326424001914	AP (apurinic/apyrimidinic) site pocket; other site
326424001915	Metal-binding active site; metal-binding site
326424001916	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
326424001917	Trans-aconitate methyltransferase [General function prediction only]; Region: Tam; COG4106
326424001918	S-adenosylmethionine binding site [chemical binding]; other site
326424001919	OpgC protein; Region: OpgC_C; cl00792
326424001920	Acyltransferase family; Region: Acyl_transf_3; pfam01757
326424001921	pyrroline-5-carboxylate reductase; Region: proC; TIGR00112
326424001922	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
326424001923	S-adenosyl-l-methionine hydroxide adenosyltransferase; Region: SAM_adeno_trans; pfam01887
326424001924	Uncharacterized conserved protein [Function unknown]; Region: COG1912
326424001925	UDP-glucose 4 epimerase (G4E), subgroup 3, extended (e) SDRs; Region: UDP_G4E_3_SDR_e; cd05240
326424001926	NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370
326424001927	putative NAD(P) binding site [chemical binding]; other site
326424001928	active site
326424001929	putative substrate binding site [chemical binding]; other site
326424001930	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
326424001931	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: MGAT-like; Region: LPLAT_MGAT-like; cd07987
326424001932	putative acyl-acceptor binding pocket; other site
326424001933	Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560
326424001934	Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391
326424001935	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
326424001936	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761
326424001937	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
326424001938	redox-sensing transcriptional repressor Rex; Provisional; Region: PRK05472
326424001939	Putative DNA-binding protein N-terminus; Region: Put_DNA-bind_N; pfam06971
326424001940	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
326424001941	glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045
326424001942	NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213
326424001943	tRNA; other site
326424001944	putative tRNA binding site [nucleotide binding]; other site
326424001945	putative NADP binding site [chemical binding]; other site
326424001946	Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745
326424001947	porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072
326424001948	Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cl03189
326424001949	active site
326424001950	domain interfaces; other site
326424001951	Precorrin-3B methylase [Coenzyme metabolism]; Region: CobJ; cl00304
326424001952	Precorrin-3B methylase [Coenzyme metabolism]; Region: CobJ; cl00304
326424001953	Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578
326424001954	active site
326424001955	Uroporphyrinogen-III synthase HemD; Region: HEM4; pfam02602
326424001956	Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cd00384
326424001957	dimer interface [polypeptide binding]; other site
326424001958	active site
326424001959	Schiff base residues; other site
326424001960	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
326424001961	metal-binding site [ion binding]
326424001962	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
326424001963	metal-binding site [ion binding]
326424001964	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217
326424001965	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
326424001966	methionyl-tRNA synthetase; Reviewed; Region: PRK11893
326424001967	catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814
326424001968	active site
326424001969	HIGH motif; other site
326424001970	KMSKS motif; other site
326424001971	Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957
326424001972	tRNA binding surface [nucleotide binding]; other site
326424001973	anticodon binding site; other site
326424001974	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
326424001975	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
326424001976	Major Facilitator Superfamily; Region: MFS_1; pfam07690
326424001977	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
326424001978	3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352
326424001979	Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830
326424001980	dimer interface [polypeptide binding]; other site
326424001981	active site
326424001982	CoA binding pocket [chemical binding]; other site
326424001983	glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062
326424001984	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
326424001985	inhibitor-cofactor binding pocket; inhibition site
326424001986	pyridoxal 5'-phosphate binding site [chemical binding]; other site
326424001987	catalytic residue [active]
326424001988	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
326424001989	catalytic core [active]
326424001990	23S rRNA methyltransferase A; Provisional; Region: rrmA; PRK11088
326424001991	23S rRNA methyltransferase A; Provisional; Region: rrmA; PRK11088
326424001992	short chain dehydrogenase; Provisional; Region: PRK06523
326424001993	classical (c) SDRs; Region: SDR_c; cd05233
326424001994	NAD(P) binding site [chemical binding]; other site
326424001995	active site
326424001996	TlpA-like family; composed of  TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966
326424001997	catalytic residues [active]
326424001998	Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788
326424001999	ResB protein required for cytochrome c biosynthesis [Posttranslational modification, protein turnover, chaperones]; Region: ResB; cl09125
326424002000	ResB-like family; Region: ResB; pfam05140
326424002001	Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504
326424002002	3-octaprenyl-4-hydroxybenzoate carboxy-lyase; Region: UbiD; cl00311
326424002003	UbiA prenyltransferase family; Region: UbiA; cl00337
326424002004	aromatic acid decarboxylase; Validated; Region: PRK05920
326424002005	Flavoprotein; Region: Flavoprotein; cl08021
326424002006	putative menaquinone biosynthesis protein, SCO4494 family; Region: mena_SCO4494; TIGR03700
326424002007	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
326424002008	FeS/SAM binding site; other site
326424002009	NMT1-like family; Region: NMT1_2; cl15260
326424002010	Predicted periplasmic solute-binding protein [General function prediction only]; Region: COG1427
326424002011	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761
326424002012	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
326424002013	active site
326424002014	phosphorylation site [posttranslational modification]
326424002015	intermolecular recognition site; other site
326424002016	Sulfite reductase, beta subunit (hemoprotein) [Inorganic ion transport and metabolism]; Region: CysI; COG0155
326424002017	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
326424002018	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
326424002019	This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713
326424002020	Active Sites [active]
326424002021	Precorrin-3B methylase [Coenzyme metabolism]; Region: CobJ; cl00304
326424002022	Tetrapyrrole (Corrin/Porphyrin) Methylases; Region: TP_methylase; pfam00590
326424002023	Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578
326424002024	Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_N; cd03416
326424002025	putative active site [active]
326424002026	Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492
326424002027	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
326424002028	Catalytic domain of Protein Kinases; Region: PKc; cd00180
326424002029	active site
326424002030	ATP binding site [chemical binding]; other site
326424002031	substrate binding site [chemical binding]; other site
326424002032	activation loop (A-loop); other site
326424002033	menaquinone biosynthesis protein, SCO4550 family; Region: mena_SCO4550; TIGR03699
326424002034	Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; cl11412
326424002035	Adenosine deaminase [Nucleotide transport and metabolism]; Region: Add; COG1816
326424002036	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
326424002037	active site
326424002038	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
326424002039	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
326424002040	Dienelactone hydrolase family; Region: DLH; pfam01738
326424002041	geranylgeranyl reductase family; Region: GG-red-SF; TIGR02032
326424002042	NADH-ubiquinone/plastoquinone oxidoreductase, chain 3; Region: Oxidored_q4; cl00535
326424002043	NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; cl15792
326424002044	Respiratory-chain NADH dehydrogenase, 30 Kd subunit; Region: Complex1_30kDa; cl15771
326424002045	Nickel-dependent hydrogenase; Region: NiFeSe_Hases; cl00417
326424002046	Respiratory-chain NADH dehydrogenase, 49 Kd subunit; Region: Complex1_49kDa; pfam00346
326424002047	Respiratory-chain NADH dehydrogenase 24 Kd subunit; Region: Complex1_24kDa; pfam01257
326424002048	TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064
326424002049	putative dimer interface [polypeptide binding]; other site
326424002050	[2Fe-2S] cluster binding site [ion binding]; other site
326424002051	NADH-quinone oxidoreductase, F subunit; Region: nuoF_fam; TIGR01959
326424002052	Respiratory-chain NADH dehydrogenase 51 Kd subunit; Region: Complex1_51K; pfam01512
326424002053	SLBB domain; Region: SLBB; pfam10531
326424002054	NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; cl11211
326424002055	NADH dehydrogenase subunit G; Validated; Region: PRK07860
326424002056	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
326424002057	catalytic loop [active]
326424002058	iron binding site [ion binding]; other site
326424002059	NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; cl11210
326424002060	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
326424002061	molybdopterin cofactor binding site; other site
326424002062	Molybdopterin-Binding, C-terminal (MopB_CT) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum-...; Region: MopB_CT; cl09929
326424002063	molybdopterin cofactor binding site; other site
326424002064	NADH dehydrogenase; Region: NADHdh; cl00469
326424002065	NADH dehydrogenase subunit I; Provisional; Region: PRK05888
326424002066	4Fe-4S binding domain; Region: Fer4; cl02805
326424002067	4Fe-4S binding domain; Region: Fer4; cl02805
326424002068	NADH-ubiquinone/plastoquinone oxidoreductase chain 6; Region: Oxidored_q3; pfam00499
326424002069	NADH-ubiquinone/plastoquinone oxidoreductase chain 4L; Region: Oxidored_q2; cl00492
326424002070	NADH:ubiquinone oxidoreductase subunit L; Reviewed; Region: PRK06590
326424002071	NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662
326424002072	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; cl14187
326424002073	NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846
326424002074	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; cl14187
326424002075	NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777
326424002076	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; cl14187
326424002077	Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142
326424002078	Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685
326424002079	substrate binding pocket [chemical binding]; other site
326424002080	chain length determination region; other site
326424002081	substrate-Mg2+ binding site; other site
326424002082	catalytic residues [active]
326424002083	aspartate-rich region 1; other site
326424002084	active site lid residues [active]
326424002085	aspartate-rich region 2; other site
326424002086	Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629
326424002087	2-oxoacid:acceptor oxidoreductase, alpha subunit; Region: OAFO_sf; TIGR03710
326424002088	Pyruvate ferredoxin/flavodoxin oxidoreductase; Region: POR; cl00546
326424002089	Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034
326424002090	dimer interface [polypeptide binding]; other site
326424002091	PYR/PP interface [polypeptide binding]; other site
326424002092	TPP binding site [chemical binding]; other site
326424002093	substrate binding site [chemical binding]; other site
326424002094	Domain of unknown function (DUF2520); Region: DUF2520; pfam10728
326424002095	Peptidase family M48; Region: Peptidase_M48; cl12018
326424002096	Protein of unknown function (DUF520); Region: DUF520; cl00723
326424002097	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
326424002098	active site
326424002099	GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661
326424002100	putative active site pocket [active]
326424002101	dimerization interface [polypeptide binding]; other site
326424002102	putative catalytic residue [active]
326424002103	Endo-N-acetylmuramidases (muramidases) are lysozymes (also referred to as peptidoglycan hydrolases) that degrade bacterial cell walls by catalyzing the hydrolysis of 1,4-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues; Region: GH25_muramidase; cd00599
326424002104	Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183
326424002105	active site
326424002106	LGFP repeat; Region: LGFP; pfam08310
326424002107	LGFP repeat; Region: LGFP; pfam08310
326424002108	Uncharacterized conserved protein [Function unknown]; Region: COG1615; cl09133
326424002109	Ribosomal protein L33; Region: Ribosomal_L33; cl00383
326424002110	(R)-hydratase [(R)-specific enoyl-CoA hydratase]. Catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway.  The structure of the monomer includes a five-strand antiparallel...; Region: R_hydratase_like; cd03441
326424002111	active site
326424002112	catalytic site [active]
326424002113	The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509
326424002114	active site 2 [active]
326424002115	active site 1 [active]
326424002116	aspartate aminotransferase; Provisional; Region: PRK05764
326424002117	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
326424002118	pyridoxal 5'-phosphate binding site [chemical binding]; other site
326424002119	homodimer interface [polypeptide binding]; other site
326424002120	catalytic residue [active]
326424002121	Evidence 2b : Function of strongly homologous gene; Product type t : transporter
326424002122	transcription antitermination protein NusG; Validated; Region: nusG; PRK05609
326424002123	Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891
326424002124	putative homodimer interface [polypeptide binding]; other site
326424002125	50S ribosomal protein L11; Validated; Region: rplK; PRK00140
326424002126	Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349
326424002127	putative thiostrepton binding site; other site
326424002128	23S rRNA interface [nucleotide binding]; other site
326424002129	L7/L12 interface [polypeptide binding]; other site
326424002130	L25 interface [polypeptide binding]; other site
326424002131	Ribosomal protein L1.  The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA.  In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403
326424002132	mRNA/rRNA interface [nucleotide binding]; other site
326424002133	Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797
326424002134	23S rRNA interface [nucleotide binding]; other site
326424002135	Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site
326424002136	Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387
326424002137	core dimer interface [polypeptide binding]; other site
326424002138	peripheral dimer interface [polypeptide binding]; other site
326424002139	L10 interface [polypeptide binding]; other site
326424002140	L11 interface [polypeptide binding]; other site
326424002141	putative EF-Tu interaction site [polypeptide binding]; other site
326424002142	putative EF-G interaction site [polypeptide binding]; other site
326424002143	DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405
326424002144	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653
326424002145	RPB12 interaction site [polypeptide binding]; other site
326424002146	RPB1 interaction site [polypeptide binding]; other site
326424002147	RPB10 interaction site [polypeptide binding]; other site
326424002148	RPB11 interaction site [polypeptide binding]; other site
326424002149	RPB3 interaction site [polypeptide binding]; other site
326424002150	DNA-directed RNA polymerase subunit beta'; Provisional; Region: PRK00566
326424002151	RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997
326424002152	RNA polymerase Rpb1, domain 2; Region: RNA_pol_Rpb1_2; cl11591
326424002153	RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983
326424002154	RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000
326424002155	Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655
326424002156	Rpb1 (beta') - Rpb6 (omega) interaction site [polypeptide binding]; other site
326424002157	Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site
326424002158	G-loop; other site
326424002159	DNA binding site [nucleotide binding]
326424002160	PseudoU_synth_RsuA/RluD: Pseudouridine synthase, RsuA/RluD family. This group is comprised of eukaryotic, bacterial and archeal proteins similar to eight site specific Escherichia coli pseudouridine synthases: RsuA, RluA, RluB, RluC, RluD, RluE, RluF and...; Region: PseudoU_synth_RluCD_like; cd02869
326424002161	active site
326424002162	PseudoU_synth_RsuA/RluD: Pseudouridine synthase, RsuA/RluD family. This group is comprised of eukaryotic, bacterial and archeal proteins similar to eight site specific Escherichia coli pseudouridine synthases: RsuA, RluA, RluB, RluC, RluD, RluE, RluF and...; Region: PseudoU_synth_RluCD_like; cd02869
326424002163	G:T/U mismatch specific DNA glcosylase (MUG); Region: UDG_F2_MUG; cd10028
326424002164	active site
326424002165	SUMO-1 interface [polypeptide binding]; other site
326424002166	S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368
326424002167	S17 interaction site [polypeptide binding]; other site
326424002168	S8 interaction site; other site
326424002169	16S rRNA interaction site [nucleotide binding]; other site
326424002170	streptomycin interaction site [chemical binding]; other site
326424002171	23S rRNA interaction site [nucleotide binding]; other site
326424002172	aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site
326424002173	Ribosomal protein S7p/S5e; Region: Ribosomal_S7; cl00313
326424002174	elongation factor G; Reviewed; Region: PRK00007
326424002175	Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886
326424002176	G1 box; other site
326424002177	putative GEF interaction site [polypeptide binding]; other site
326424002178	GTP/Mg2+ binding site [chemical binding]; other site
326424002179	Switch I region; other site
326424002180	G2 box; other site
326424002181	G3 box; other site
326424002182	Switch II region; other site
326424002183	G4 box; other site
326424002184	G5 box; other site
326424002185	EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088
326424002186	EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434
326424002187	EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G.  Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713
326424002188	elongation factor Tu; Reviewed; Region: PRK00049
326424002189	Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884
326424002190	G1 box; other site
326424002191	GEF interaction site [polypeptide binding]; other site
326424002192	GTP/Mg2+ binding site [chemical binding]; other site
326424002193	Switch I region; other site
326424002194	G2 box; other site
326424002195	G3 box; other site
326424002196	Switch II region; other site
326424002197	G4 box; other site
326424002198	G5 box; other site
326424002199	EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697
326424002200	Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707
326424002201	Antibiotic Binding Site [chemical binding]; other site
326424002202	Ribosomal protein S10p/S20e; Region: Ribosomal_S10; cl00314
326424002203	Ribosomal protein L3; Region: Ribosomal_L3; cl00324
326424002204	Ribosomal protein L4/L1 family; Region: Ribosomal_L4; cl00325
326424002205	Ribosomal protein L23; Region: Ribosomal_L23; cl00326
326424002206	50S ribosomal protein L2; Validated; Region: rplB; PRK09374
326424002207	Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181
326424002208	Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947
326424002209	Ribosomal protein S19; Region: Ribosomal_S19; cl00350
326424002210	Ribosomal protein L22/L17e.  L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit.  It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336
326424002211	putative translocon binding site; other site
326424002212	protein-rRNA interface [nucleotide binding]; other site
326424002213	30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310
326424002214	K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3  is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel.  The KH...; Region: 30S_S3_KH; cd02412
326424002215	G-X-X-G motif; other site
326424002216	Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189
326424002217	Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433
326424002218	23S rRNA interface [nucleotide binding]; other site
326424002219	5S rRNA interface [nucleotide binding]; other site
326424002220	putative antibiotic binding site [chemical binding]; other site
326424002221	L25 interface [polypeptide binding]; other site
326424002222	L27 interface [polypeptide binding]; other site
326424002223	Ribosomal L29 protein/HIP.  L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals.  L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427
326424002224	putative translocon interaction site; other site
326424002225	23S rRNA interface [nucleotide binding]; other site
326424002226	signal recognition particle (SRP54) interaction site; other site
326424002227	L23 interface [polypeptide binding]; other site
326424002228	trigger factor interaction site; other site
326424002229	Ribosomal protein S17; Region: Ribosomal_S17; cl00351
326424002230	Ribosomal protein L14p/L23e; Region: Ribosomal_L14; cl00328
326424002231	50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004
326424002232	KOW motif; Region: KOW; cl00354
326424002233	50S ribosomal protein L5; Validated; Region: rplE; PRK00010
326424002234	Ribosomal protein L5; Region: Ribosomal_L5; pfam00281
326424002235	ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673
326424002236	Ribosomal protein S14p/S29e; Region: Ribosomal_S14; cl00355
326424002237	Ribosomal protein S8; Region: Ribosomal_S8; cl00330
326424002238	50S ribosomal protein L6; Validated; Region: rplF; PRK05498
326424002239	Ribosomal protein L6; Region: Ribosomal_L6; pfam00347
326424002240	Ribosomal protein L6; Region: Ribosomal_L6; pfam00347
326424002241	Ribosomal L18/L5e:  L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432
326424002242	5S rRNA interface [nucleotide binding]; other site
326424002243	23S rRNA interface [nucleotide binding]; other site
326424002244	L5 interface [polypeptide binding]; other site
326424002245	30S ribosomal protein S5; Validated; Region: rpsE; PRK00550
326424002246	Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333
326424002247	Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719
326424002248	Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658
326424002249	23S rRNA binding site [nucleotide binding]; other site
326424002250	Ribosomal protein L18e/L15; Region: Ribosomal_L18e; cl12022
326424002251	preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204
326424002252	SecY translocase; Region: SecY; pfam00344
326424002253	adenylate kinase; Reviewed; Region: adk; PRK00279
326424002254	Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428
326424002255	AMP-binding site [chemical binding]; other site
326424002256	ATP-AMP (Ap5A)-binding site [chemical binding]; other site
326424002257	Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086
326424002258	active site
326424002259	S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451
326424002260	rRNA binding site [nucleotide binding]; other site
326424002261	predicted 30S ribosome binding site; other site
326424002262	Ribosomal protein L36; Region: Ribosomal_L36; cl00380
326424002263	Ribosomal protein S13/S18; Region: Ribosomal_S13; cl00331
326424002264	Ribosomal protein S11; Region: Ribosomal_S11; cl00332
326424002265	30S ribosomal protein S4; Validated; Region: rpsD; PRK05327
326424002266	Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163
326424002267	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
326424002268	RNA binding surface [nucleotide binding]; other site
326424002269	DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182
326424002270	N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928
326424002271	alphaNTD - beta interaction site [polypeptide binding]; other site
326424002272	alphaNTD homodimer interface [polypeptide binding]; other site
326424002273	alphaNTD - beta' interaction site [polypeptide binding]; other site
326424002274	Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; cl11613
326424002275	Ribosomal protein L17; Region: Ribosomal_L17; cl00356
326424002276	PseudoU_synth_EcTruA: Pseudouridine synthase, Escherichia coli TruA like. This group consists of eukaryotic and bacterial pseudouridine synthases similar to E.  coli TruA, Pseudomonas aeruginosa truA and human pseudouridine synthase-like 1 (PUSL1); Region: PseudoU_synth_EcTruA; cd02570
326424002277	tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021
326424002278	dimerization interface 3.5A [polypeptide binding]; other site
326424002279	active site
326424002280	Ribosomal protein L13.  Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392
326424002281	23S rRNA interface [nucleotide binding]; other site
326424002282	L3 interface [polypeptide binding]; other site
326424002283	Ribosomal protein S9/S16; Region: Ribosomal_S9; cl00334
326424002284	phosphoglucosamine mutase; Provisional; Region: glmM; PRK14318
326424002285	GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802
326424002286	active site
326424002287	substrate binding site [chemical binding]; other site
326424002288	metal binding site [ion binding]; metal-binding site
326424002289	glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331
326424002290	Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans).  The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714
326424002291	glutaminase active site [active]
326424002292	SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008
326424002293	dimer interface [polypeptide binding]; other site
326424002294	active site
326424002295	SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009
326424002296	dimer interface [polypeptide binding]; other site
326424002297	active site
326424002298	SWIM zinc finger; Region: SWIM; cl15408
326424002299	Helix-turn-helix domains; Region: HTH; cl00088
326424002300	4'-phosphopantetheinyl transferase superfamily; Region: ACPS; cl00500
326424002301	YjeF-related protein N-terminus; Region: YjeF_N; cl00318
326424002302	B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171
326424002303	putative ATP binding site [chemical binding]; other site
326424002304	putative substrate binding site [chemical binding]; other site
326424002305	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430
326424002306	alanine racemase; Reviewed; Region: alr; PRK00053
326424002307	dimer interface [polypeptide binding]; other site
326424002308	active site
326424002309	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
326424002310	substrate binding site [chemical binding]; other site
326424002311	catalytic residues [active]
326424002312	serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011
326424002313	Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378
326424002314	dimer interface [polypeptide binding]; other site
326424002315	glycine-pyridoxal phosphate binding site [chemical binding]; other site
326424002316	active site
326424002317	folate binding site [chemical binding]; other site
326424002318	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
326424002319	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
326424002320	Uncharacterized P-loop hydrolase UPF0079; Region: UPF0079; cl00520
326424002321	Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl14000
326424002322	ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575
326424002323	NADPH-dependent FMN reductase; Region: FMN_red; cl00438
326424002324	Helix-turn-helix domains; Region: HTH; cl00088
326424002325	Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320
326424002326	oligomerisation interface [polypeptide binding]; other site
326424002327	mobile loop; other site
326424002328	roof hairpin; other site
326424002329	chaperonin GroEL; Reviewed; Region: groEL; PRK12849
326424002330	GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344
326424002331	ring oligomerisation interface [polypeptide binding]; other site
326424002332	ATP/Mg binding site [chemical binding]; other site
326424002333	stacking interactions; other site
326424002334	hinge regions; other site
326424002335	Transcription factor WhiB; Region: Whib; pfam02467
326424002336	inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567
326424002337	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl09108
326424002338	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a key...; Region: CBS_pair_IMPDH; cd04601
326424002339	IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of the guanine...; Region: IMPDH; cd00381
326424002340	active site
326424002341	inosine 5-monophosphate dehydrogenase; Validated; Region: PRK08649
326424002342	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl09108
326424002343	phosphate binding site [ion binding]; other site
326424002344	Periplasmic binding protein; Region: Peripla_BP_6; pfam13458
326424002345	Type I periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type active transport systems that are predicted to be involved in transport of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_4; cd06337
326424002346	putative ligand binding site [chemical binding]; other site
326424002347	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
326424002348	Protein of unknown function (DUF742); Region: DUF742; pfam05331
326424002349	Roadblock/LC7 domain; Region: Robl_LC7; cl00886
326424002350	Nitrate and nitrite sensing; Region: NIT; pfam08376
326424002351	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
326424002352	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
326424002353	ATP binding site [chemical binding]; other site
326424002354	Mg2+ binding site [ion binding]; other site
326424002355	G-X-G motif; other site
326424002356	GMP synthase; Reviewed; Region: guaA; PRK00074
326424002357	Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742
326424002358	AMP/PPi binding site [chemical binding]; other site
326424002359	candidate oxyanion hole; other site
326424002360	catalytic triad [active]
326424002361	potential glutamine specificity residues [chemical binding]; other site
326424002362	The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997
326424002363	ATP Binding subdomain [chemical binding]; other site
326424002364	Ligand Binding sites [chemical binding]; other site
326424002365	Dimerization subdomain; other site
326424002366	Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342
326424002367	hypothetical protein; Provisional; Region: PRK06815
326424002368	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
326424002369	catalytic residue [active]
326424002370	ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073
326424002371	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
326424002372	Family description; Region: UvrD_C_2; cl15862
326424002373	Predicted acetyltransferases and hydrolases with the alpha/beta hydrolase fold [General function prediction only]; Region: LipA; COG1075
326424002374	Acetyl-CoA carboxylase beta subunit [Lipid metabolism]; Region: AccD; COG0777
326424002375	Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl15772
326424002376	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
326424002377	Catalytic domain of Protein Kinases; Region: PKc; cd00180
326424002378	active site
326424002379	ATP binding site [chemical binding]; other site
326424002380	substrate binding site [chemical binding]; other site
326424002381	activation loop (A-loop); other site
326424002382	Domain of unknown function (DUF4190); Region: DUF4190; pfam13828
326424002383	succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696
326424002384	ATP-grasp domain; Region: ATP-grasp_4; cl03087
326424002385	CoA-ligase; Region: Ligase_CoA; cl02894
326424002386	succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678
326424002387	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
326424002388	CoA-ligase; Region: Ligase_CoA; cl02894
326424002389	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761
326424002390	phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647
326424002391	Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645
326424002392	active site
326424002393	substrate binding site [chemical binding]; other site
326424002394	cosubstrate binding site; other site
326424002395	catalytic site [active]
326424002396	bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881
326424002397	Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal  ATIC formylase domain that formylates...; Region: IMPCH; cd01421
326424002398	purine monophosphate binding site [chemical binding]; other site
326424002399	dimer interface [polypeptide binding]; other site
326424002400	putative catalytic residues [active]
326424002401	AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362
326424002402	AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362
326424002403	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
326424002404	phosphopeptide binding site; other site
326424002405	Helix-turn-helix domains; Region: HTH; cl00088
326424002406	Protein of unknown function (DUF3017); Region: DUF3017; pfam11222
326424002407	Dehydrogenases (flavoproteins) [Energy production and conversion]; Region: FixC; COG0644
326424002408	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
326424002409	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009
326424002410	LigT like Phosphoesterase; Region: LigT_PEase; pfam02834
326424002411	2'-5' RNA ligase superfamily; Region: 2_5_RNA_ligase2; pfam13563
326424002412	Virulence factor BrkB; Region: Virul_fac_BrkB; cl07918
326424002413	D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686
326424002414	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009
326424002415	Protein of unknown function (DUF1003); Region: DUF1003; cl01831
326424002416	Uncharacterized protein conserved in bacteria (DUF2248); Region: DUF2248; pfam10005
326424002417	Uncharacterized protein conserved in bacteria (DUF2248); Region: DUF2248; pfam10005
326424002418	N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357
326424002419	TIR domain; Region: TIR_2; cl15770
326424002420	probable pectinesterase/pectinesterase inhibitor; Region: PLN02217
326424002421	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
326424002422	binding surface
326424002423	TPR motif; other site
326424002424	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
326424002425	ATP binding site [chemical binding]; other site
326424002426	putative Mg++ binding site [ion binding]; other site
326424002427	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
326424002428	nucleotide binding region [chemical binding]; other site
326424002429	ATP-binding site [chemical binding]; other site
326424002430	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cl00159
326424002431	succinate dehydrogenase and fumarate reductase iron-sulfur protein; Region: dhsB; TIGR00384
326424002432	succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK08205
326424002433	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
326424002434	Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910
326424002435	Succinate:quinone oxidoreductase (SQR) Type A subfamily, Succinate dehydrogenase D (SdhD)-like subunit; SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. Members of this subfamily reduce low potential...; Region: SQR_TypeA_SdhD_like; cd03500
326424002436	putative Iron-sulfur protein interface [polypeptide binding]; other site
326424002437	putative proximal heme binding site [chemical binding]; other site
326424002438	putative SdhC-like subunit interface [polypeptide binding]; other site
326424002439	putative distal heme binding site [chemical binding]; other site
326424002440	Succinate:quinone oxidoreductase (SQR) Type A subfamily, Succinate dehydrogenase C (SdhC)-like subunit; SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. Members of this subfamily reduce low potential...; Region: SQR_TypeA_SdhC_like; cd03501
326424002441	putative Iron-sulfur protein interface [polypeptide binding]; other site
326424002442	putative proximal heme binding site [chemical binding]; other site
326424002443	putative SdhD-like interface [polypeptide binding]; other site
326424002444	putative distal heme binding site [chemical binding]; other site
326424002445	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
326424002446	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
326424002447	active site
326424002448	ATP binding site [chemical binding]; other site
326424002449	substrate binding site [chemical binding]; other site
326424002450	activation loop (A-loop); other site
326424002451	Catalytic domain of Protein Kinases; Region: PKc; cd00180
326424002452	active site
326424002453	ATP binding site [chemical binding]; other site
326424002454	substrate binding site [chemical binding]; other site
326424002455	activation loop (A-loop); other site
326424002456	PsbP; Region: PsbP; cl03356
326424002457	Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283
326424002458	active site
326424002459	catalytic motif [active]
326424002460	Zn binding site [ion binding]; other site
326424002461	thymidine phosphorylase; Reviewed; Region: deoA; PRK05820
326424002462	Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885
326424002463	Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591
326424002464	Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; cl06734
326424002465	Adenosine deaminase [Nucleotide transport and metabolism]; Region: Add; COG1816
326424002466	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
326424002467	active site
326424002468	Methyladenine glycosylase; Region: Adenine_glyco; cl01059
326424002469	2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959
326424002470	intersubunit interface [polypeptide binding]; other site
326424002471	active site
326424002472	catalytic residue [active]
326424002473	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
326424002474	active site
326424002475	phosphoglucomutase-2-like protein; Provisional; Region: PTZ00150
326424002476	This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...; Region: PGM2; cd05799
326424002477	active site
326424002478	substrate binding site [chemical binding]; other site
326424002479	metal binding site [ion binding]; metal-binding site
326424002480	Phosphorylase superfamily; Region: PNP_UDP_1; cl00303
326424002481	aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476
326424002482	EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317
326424002483	dimer interface [polypeptide binding]; other site
326424002484	anticodon binding site; other site
326424002485	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it attaches...; Region: class_II_aaRS-like_core; cl00268
326424002486	motif 1; other site
326424002487	dimer interface [polypeptide binding]; other site
326424002488	active site
326424002489	motif 2; other site
326424002490	GAD domain; Region: GAD; pfam02938
326424002491	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it attaches...; Region: class_II_aaRS-like_core; cl00268
326424002492	active site
326424002493	motif 3; other site
326424002494	Glutamate-cysteine ligase family 2(GCS2); Region: GCS2; cl00954
326424002495	carboxylate-amine ligase, YbdK family; Region: gshA_cyan_rel; TIGR02050
326424002496	Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473
326424002497	M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like4; cd08014
326424002498	metal binding site [ion binding]; metal-binding site
326424002499	putative dimer interface [polypeptide binding]; other site
326424002500	GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661
326424002501	putative active site pocket [active]
326424002502	dimerization interface [polypeptide binding]; other site
326424002503	GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cl15777
326424002504	putative catalytic residue [active]
326424002505	flavoprotein disulfide reductase; Reviewed; Region: PRK07845
326424002506	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
326424002507	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
326424002508	Domain of unknown function (DUF222); Region: DUF222; pfam02720
326424002509	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
326424002510	active site
326424002511	Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770
326424002512	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
326424002513	ATP-grasp domain; Region: ATP-grasp_4; cl03087
326424002514	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; cl08365
326424002515	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
326424002516	carboxyltransferase (CT) interaction site; other site
326424002517	biotinylation site [posttranslational modification]; other site
326424002518	Acyl-CoA carboxylase epsilon subunit; Region: ACC_epsilon; pfam13822
326424002519	methylmalonyl-CoA decarboxylase alpha subunit; Region: mmdA; TIGR01117
326424002520	Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl15772
326424002521	Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl15772
326424002522	Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340
326424002523	Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057
326424002524	Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237
326424002525	Bacterial PH domain; Region: DUF304; cl01348
326424002526	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
326424002527	Helix-turn-helix domains; Region: HTH; cl00088
326424002528	GtrA-like protein; Region: GtrA; cl00971
326424002529	Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeD; cd03379
326424002530	active site clefts [active]
326424002531	zinc binding site [ion binding]; other site
326424002532	dimer interface [polypeptide binding]; other site
326424002533	Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004
326424002534	UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984
326424002535	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
326424002536	AMP-binding enzyme; Region: AMP-binding; cl15778
326424002537	Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581
326424002538	LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399
326424002539	G1P_TT_long represents the long form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_long; cd04189
326424002540	glucose-1-phosphate thymidylylransferase, long form; Region: rmlA_long; TIGR01208
326424002541	substrate binding site; other site
326424002542	metal-binding site
326424002543	Oligomer interface; other site
326424002544	Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160
326424002545	Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581
326424002546	LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399
326424002547	dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254
326424002548	RmlD substrate binding domain; Region: RmlD_sub_bind; pfam04321
326424002549	NADP binding site [chemical binding]; other site
326424002550	active site
326424002551	putative substrate binding site [chemical binding]; other site
326424002552	mycofactocin system transcriptional regulator; Region: mycofact_TetR; TIGR03968
326424002553	Helix-turn-helix domains; Region: HTH; cl00088
326424002554	drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711
326424002555	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cl11420
326424002556	This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809
326424002557	Glycosyltransferase Family 4; Region: Glyco_transf_4; pfam13439
326424002558	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
326424002559	Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186
326424002560	Probable Catalytic site; other site
326424002561	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
326424002562	ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134
326424002563	ABC_KpsT_Wzt   The KpsT/Wzt ABC transporter subfamily is involved in extracellular polysaccharide export.  Among the variety of membrane-linked or extracellular polysaccharides excreted by bacteria, only capsular polysaccharides, lipopolysaccharides, and...; Region: ABC_KpsT_Wzt; cd03220
326424002564	Walker A/P-loop; other site
326424002565	ATP binding site [chemical binding]; other site
326424002566	Q-loop/lid; other site
326424002567	ABC transporter signature motif; other site
326424002568	Walker B; other site
326424002569	D-loop; other site
326424002570	H-loop/switch region; other site
326424002571	ABC-2 type transporter; Region: ABC2_membrane; cl11417
326424002572	Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391
326424002573	Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419
326424002574	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
326424002575	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_5; cd07238
326424002576	dimer interface [polypeptide binding]; other site
326424002577	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
326424002578	Catalytic domain of Protein Kinases; Region: PKc; cd00180
326424002579	active site
326424002580	ATP binding site [chemical binding]; other site
326424002581	substrate binding site [chemical binding]; other site
326424002582	activation loop (A-loop); other site
326424002583	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200
326424002584	structural tetrad; other site
326424002585	Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl15769
326424002586	Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110
326424002587	Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647
326424002588	trimer interface [polypeptide binding]; other site
326424002589	active site
326424002590	substrate binding site [chemical binding]; other site
326424002591	CoA binding site [chemical binding]; other site
326424002592	glycosyltransferase, TIGR04182 family; Region: glyco_TIGR04182
326424002593	DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179
326424002594	Ligand binding site; other site
326424002595	Putative Catalytic site; other site
326424002596	DXD motif; other site
326424002597	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
326424002598	Methyltransferase domain; Region: Methyltransf_31; pfam13847
326424002599	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
326424002600	S-adenosylmethionine binding site [chemical binding]; other site
326424002601	This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809
326424002602	This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809
326424002603	Glycosyltransferase Family 4; Region: Glyco_transf_4; pfam13439
326424002604	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
326424002605	Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186
326424002606	Probable Catalytic site; other site
326424002607	metal-binding site
326424002608	NTP_transferases catalyze the transfer of nucleotides onto phosphosugars; Region: NTP_transferase; cd04181
326424002609	Substrate binding site; other site
326424002610	Mg++ binding site; other site
326424002611	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075
326424002612	DNA polymerase III subunit beta; Validated; Region: PRK07761
326424002613	Beta clamp domain.  The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria.  The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140
326424002614	putative DNA binding surface [nucleotide binding]; other site
326424002615	dimer interface [polypeptide binding]; other site
326424002616	beta-clamp/clamp loader binding surface; other site
326424002617	beta-clamp/translesion DNA polymerase binding surface; other site
326424002618	Protein of unknown function (DUF3105); Region: DUF3105; pfam11303
326424002619	F420-0--gamma-glutamyl ligase; Provisional; Region: PRK13294
326424002620	F420-0:Gamma-glutamyl ligase; Region: F420_ligase; cl00644
326424002621	Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer,  utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514
326424002622	dimer interface [polypeptide binding]; other site
326424002623	Family of CofD-like proteins and proteins related to YvcK; Region: CofD_YvcK; cl00425
326424002624	phosphate binding site [ion binding]; other site
326424002625	dimer interface [polypeptide binding]; other site
326424002626	DNA-binding transcriptional repressor AcrR; Provisional; Region: PRK10668
326424002627	Helix-turn-helix domains; Region: HTH; cl00088
326424002628	FO synthase; Reviewed; Region: fbiC; PRK09234
326424002629	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
326424002630	FeS/SAM binding site; other site
326424002631	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
326424002632	FeS/SAM binding site; other site
326424002633	Transcription factor WhiB; Region: Whib; pfam02467
326424002634	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
326424002635	Predicted glycosyltransferases [General function prediction only]; Region: COG1216
326424002636	Phosphomannose isomerase type I; Region: PMI_typeI; cl15429
326424002637	Phosphomannose isomerase type I; Region: PMI_typeI; cl15429
326424002638	Possibl zinc metallo-peptidase; Region: DUF1025; cl01577
326424002639	Protein of unknown function (DUF3499); Region: DUF3499; pfam12005
326424002640	The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a...; Region: PMM_PGM; cd03089
326424002641	phosphomannomutase/phosphoglucomutase; Reviewed; Region: manB; PRK09542
326424002642	active site
326424002643	substrate binding site [chemical binding]; other site
326424002644	metal binding site [ion binding]; metal-binding site
326424002645	Trm112p-like protein; Region: Trm112p; cl01066
326424002646	SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS; cl00389
326424002647	The members of this protein family contain the SIS (Sugar ISomerase) domain and have both the phosphoglucose isomerase (PGI) and the phosphomannose isomerase (PMI) functions. These functions catalyze the reversible reactions of glucose 6-phosphate to...; Region: SIS_PGI_PMI_2; cd05637
326424002648	dimer interface [polypeptide binding]; other site
326424002649	active site
326424002650	RsbT co-antagonist protein rsbRD N-terminal domain; Region: RsbRD_N; pfam14361
326424002651	Sulphate Transporter and Anti-Sigma factor antagonist domain of the 'stressosome' complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041
326424002652	Sulphate Transporter and Anti-Sigma factor antagonist domain of the 'stressosome' complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041
326424002653	Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581
326424002654	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075
326424002655	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075
326424002656	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
326424002657	dimer interface [polypeptide binding]; other site
326424002658	phosphorylation site [posttranslational modification]
326424002659	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
326424002660	ATP binding site [chemical binding]; other site
326424002661	Mg2+ binding site [ion binding]; other site
326424002662	G-X-G motif; other site
326424002663	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
326424002664	active site
326424002665	phosphorylation site [posttranslational modification]
326424002666	intermolecular recognition site; other site
326424002667	dimerization interface [polypeptide binding]; other site
326424002668	Response regulator receiver domain; Region: Response_reg; pfam00072
326424002669	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
326424002670	active site
326424002671	phosphorylation site [posttranslational modification]
326424002672	intermolecular recognition site; other site
326424002673	dimerization interface [polypeptide binding]; other site
326424002674	Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cl00120
326424002675	Transglycosylase; Region: Transgly; cl07896
326424002676	penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074
326424002677	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009
326424002678	Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600
326424002679	DNA binding residues [nucleotide binding]
326424002680	S-adenosyl-L-homocysteine hydrolase; Provisional; Region: PRK05476
326424002681	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
326424002682	oligomerization interface [polypeptide binding]; other site
326424002683	active site
326424002684	NAD+ binding site [chemical binding]; other site
326424002685	RDD family; Region: RDD; cl00746
326424002686	Response regulator of citrate/malate metabolism [Transcription / Signal transduction mechanisms]; Region: CitB; COG4565
326424002687	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
326424002688	active site
326424002689	phosphorylation site [posttranslational modification]
326424002690	intermolecular recognition site; other site
326424002691	dimerization interface [polypeptide binding]; other site
326424002692	3-oxoacyl-(acyl-carrier-protein) synthase [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: FabB; COG0304
326424002693	Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938
326424002694	active site
326424002695	polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833
326424002696	Beta-ketoacyl synthase; Region: PKS_KS; smart00825
326424002697	active site
326424002698	malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128
326424002699	Acyl transferase domain; Region: Acyl_transf_1; cl08282
326424002700	Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826
326424002701	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
326424002702	enoyl reductase of polyketide synthase; Region: enoyl_red; cd05195
326424002703	Enoylreductase; Region: PKS_ER; smart00829
326424002704	NAD(P) binding site [chemical binding]; other site
326424002705	beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 2, complex (x); Region: KR_2_FAS_SDR_x; cd08955
326424002706	putative NADP binding site [chemical binding]; other site
326424002707	active site
326424002708	Phosphopantetheine attachment site; Region: PP-binding; cl09936
326424002709	Integral membrane protein DUF95; Region: DUF95; cl00572
326424002710	Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381
326424002711	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
326424002712	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_19; cd07262
326424002713	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
326424002714	Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933
326424002715	FMN binding site [chemical binding]; other site
326424002716	active site
326424002717	substrate binding site [chemical binding]; other site
326424002718	catalytic residue [active]
326424002719	Domain of unknown function (DUF385); Region: DUF385; cl04387
326424002720	Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721
326424002721	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057
326424002722	MoxR-like ATPases [General function prediction only]; Region: COG0714
326424002723	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
326424002724	Walker A motif; other site
326424002725	ATP binding site [chemical binding]; other site
326424002726	Walker B motif; other site
326424002727	arginine finger; other site
326424002728	Domain of unknown function (DUF4350); Region: DUF4350; pfam14258
326424002729	RaiA ('ribosome-associated inhibitor A', also known as Protein Y (PY), YfiA, and SpotY,  is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal A site; Region: RaiA; cd00552
326424002730	30S subunit binding site; other site
326424002731	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
326424002732	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
326424002733	active site
326424002734	phosphorylation site [posttranslational modification]
326424002735	intermolecular recognition site; other site
326424002736	dimerization interface [polypeptide binding]; other site
326424002737	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
326424002738	DNA binding residues [nucleotide binding]
326424002739	dimerization interface [polypeptide binding]; other site
326424002740	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
326424002741	N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357
326424002742	preprotein translocase subunit SecA; Reviewed; Region: PRK12904
326424002743	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
326424002744	SecA preprotein cross-linking domain; Region: SecA_PP_bind; cl03078
326424002745	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
326424002746	nucleotide binding region [chemical binding]; other site
326424002747	SEC-C motif; Region: SEC-C; pfam02810
326424002748	LysM domain/BON superfamily protein; Provisional; Region: PRK11198
326424002749	Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600
326424002750	SAF domain; Region: SAF; cl00555
326424002751	Flp pilus assembly protein, ATPase CpaE [Intracellular trafficking and secretion]; Region: CpaE; COG4963
326424002752	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
326424002753	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761
326424002754	Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396
326424002755	Uncharacterized conserved protein [Function unknown]; Region: COG3743
326424002756	PAS fold; Region: PAS; pfam00989
326424002757	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
326424002758	putative active site [active]
326424002759	heme pocket [chemical binding]; other site
326424002760	PAS fold; Region: PAS_7; pfam12860
326424002761	Flp pilus assembly protein, ATPase CpaF [Intracellular trafficking and secretion]; Region: CpaF; COG4962
326424002762	Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130
326424002763	ATP binding site [chemical binding]; other site
326424002764	Walker A motif; other site
326424002765	hexamer interface [polypeptide binding]; other site
326424002766	Walker B motif; other site
326424002767	Type II secretion system (T2SS), protein F; Region: T2SF; cl00906
326424002768	Bacterial type II secretion system protein F domain; Region: GSPII_F; cl00906
326424002769	RDD family; Region: RDD; cl00746
326424002770	RNA polymerase sigma-70 factor, sigma-E family; Region: SigE-fam_strep; TIGR02983
326424002771	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
326424002772	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
326424002773	DNA binding residues [nucleotide binding]
326424002774	4-Oxalocrotonate Tautomerase:  Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235
326424002775	active site 1 [active]
326424002776	dimer interface [polypeptide binding]; other site
326424002777	hexamer interface [polypeptide binding]; other site
326424002778	active site 2 [active]
326424002779	Phosphotransferase enzyme family; Region: APH; pfam01636
326424002780	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
326424002781	active site
326424002782	ATP binding site [chemical binding]; other site
326424002783	substrate binding site [chemical binding]; other site
326424002784	Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415
326424002785	Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415
326424002786	Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415
326424002787	Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415
326424002788	Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415
326424002789	Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540
326424002790	Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415
326424002791	Isoprenoid Biosynthesis enzymes, Class 1; Region: Isoprenoid_Biosyn_C1; cl00210
326424002792	substrate binding pocket [chemical binding]; other site
326424002793	substrate-Mg2+ binding site; other site
326424002794	aspartate-rich region 1; other site
326424002795	aspartate-rich region 2; other site
326424002796	Catalytic domain of Protein Kinases; Region: PKc; cd00180
326424002797	active site
326424002798	ATP binding site [chemical binding]; other site
326424002799	substrate binding site [chemical binding]; other site
326424002800	activation loop (A-loop); other site
326424002801	SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450
326424002802	haloacid dehalogenase-like hydrolase family protein; Region: PLN02919
326424002803	NHL repeat; Region: NHL; pfam01436
326424002804	NHL repeat; Region: NHL; pfam01436
326424002805	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
326424002806	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200
326424002807	structural tetrad; other site
326424002808	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200
326424002809	structural tetrad; other site
326424002810	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567
326424002811	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
326424002812	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
326424002813	active site
326424002814	phosphorylation site [posttranslational modification]
326424002815	intermolecular recognition site; other site
326424002816	dimerization interface [polypeptide binding]; other site
326424002817	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
326424002818	DNA binding site [nucleotide binding]
326424002819	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054
326424002820	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
326424002821	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
326424002822	ATP binding site [chemical binding]; other site
326424002823	Mg2+ binding site [ion binding]; other site
326424002824	G-X-G motif; other site
326424002825	NMT1-like family; Region: NMT1_2; cl15260
326424002826	ABC-2 type transporter; Region: ABC2_membrane; cl11417
326424002827	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
326424002828	daunorubicin resistance ABC transporter ATP-binding subunit; Region: drrA; TIGR01188
326424002829	Walker A/P-loop; other site
326424002830	ATP binding site [chemical binding]; other site
326424002831	Q-loop/lid; other site
326424002832	ABC transporter signature motif; other site
326424002833	Walker B; other site
326424002834	D-loop; other site
326424002835	H-loop/switch region; other site
326424002836	Helix-turn-helix domains; Region: HTH; cl00088
326424002837	Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909
326424002838	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
326424002839	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
326424002840	active site
326424002841	ATP binding site [chemical binding]; other site
326424002842	substrate binding site [chemical binding]; other site
326424002843	activation loop (A-loop); other site
326424002844	peptide chain release factor 2; Validated; Region: prfB; PRK00578
326424002845	RF-1 domain; Region: RF-1; cl02875
326424002846	RF-1 domain; Region: RF-1; cl02875
326424002847	Putative catalytic NodB homology domain of PgaB, IcaB, and similar proteins which consist of a deformed (beta/alpha)8 barrel fold with 5- or 6-strands; Region: CE4_NodB_like_5s_6s; cd10918
326424002848	putative active site [active]
326424002849	putative metal binding site [ion binding]; other site
326424002850	bifunctional uroporphyrinogen-III synthetase/response regulator domain protein; Validated; Region: PRK07239
326424002851	Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578
326424002852	active site
326424002853	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
326424002854	DNA binding site [nucleotide binding]
326424002855	nitrite reductase subunit NirD; Provisional; Region: PRK14989
326424002856	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
326424002857	BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; cl01093
326424002858	BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; cl01093
326424002859	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
326424002860	Assimilatory nitrite reductase (NirD) family, Rieske domain; Assimilatory nitrate and nitrite reductases convert nitrate through nitrite to ammonium. Members include bacterial and fungal proteins. The bacterial NirD contains a single Rieske domain while...; Region: Rieske_NirD; cd03529
326424002861	Tetrapyrrole (Corrin/Porphyrin) Methylases; Region: TP_methylase; pfam00590
326424002862	Precorrin-3B methylase [Coenzyme metabolism]; Region: CobJ; cl00304
326424002863	Glycosyl hydrolase family 26; Region: Glyco_hydro_26; cl09200
326424002864	dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606
326424002865	Glucose / Sorbosone dehydrogenase; Region: GSDH; pfam07995
326424002866	Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884
326424002867	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
326424002868	Walker A/P-loop; other site
326424002869	ATP binding site [chemical binding]; other site
326424002870	Q-loop/lid; other site
326424002871	ABC transporter signature motif; other site
326424002872	Walker B; other site
326424002873	D-loop; other site
326424002874	H-loop/switch region; other site
326424002875	Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177
326424002876	FtsX-like permease family; Region: FtsX; cl15850
326424002877	Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294
326424002878	SmpB-tmRNA interface; other site
326424002879	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
326424002880	S-adenosylmethionine binding site [chemical binding]; other site
326424002881	Protein of unknown function (DUF1275); Region: DUF1275; cl01453
326424002882	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632
326424002883	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
326424002884	active site
326424002885	metal binding site [ion binding]; metal-binding site
326424002886	Caspase, interleukin-1 beta converting enzyme (ICE) homologues; Cysteine-dependent aspartate-directed proteases that mediate programmed cell death (apoptosis). Caspases are synthesized as inactive zymogens and activated by proteolysis of the peptide...; Region: CASc; cl00042
326424002887	Domain of unknown function (DUF4379); Region: DUF4379; pfam14311
326424002888	Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277
326424002889	Domain of unknown function (DUF3387); Region: DUF3387; pfam11867
326424002890	Domain of unknown function (DUF3387); Region: DUF3387; pfam11867
326424002891	Nucleotidyltransferase (NT) domain of 2'5'-oligoadenylate (2-5A)synthetase (2-5OAS) and class I CCA-adding enzyme; Region: NT_2-5OAS_ClassI-CCAase; cd05400
326424002892	active site
326424002893	NTP binding site [chemical binding]; other site
326424002894	metal binding triad [ion binding]; metal-binding site
326424002895	Protein of unknown function (DUF1330); Region: DUF1330; cl02288
326424002896	Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109
326424002897	3-ketoacyl-(acyl-carrier-protein) reductase; Reviewed; Region: PRK12826
326424002898	classical (c) SDRs; Region: SDR_c; cd05233
326424002899	NAD(P) binding site [chemical binding]; other site
326424002900	active site
326424002901	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
326424002902	Rhodococcus ruber 6-oxolauric acid dehydrogenase-like and related proteins; Region: ALDH_CddD-AldA-like; cd07089
326424002903	NAD binding site [chemical binding]; other site
326424002904	catalytic residues [active]
326424002905	Response regulator of citrate/malate metabolism [Transcription / Signal transduction mechanisms]; Region: CitB; COG4565
326424002906	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
326424002907	active site
326424002908	phosphorylation site [posttranslational modification]
326424002909	intermolecular recognition site; other site
326424002910	dimerization interface [polypeptide binding]; other site
326424002911	Helix-turn-helix domains; Region: HTH; cl00088
326424002912	Sodium:dicarboxylate symporter family; Region: SDF; cl00573
326424002913	S-adenosyl methyltransferase; Region: Methyltransf_19; pfam04672
326424002914	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
326424002915	S-adenosylmethionine binding site [chemical binding]; other site
326424002916	Transcriptional regulator [Transcription]; Region: LysR; COG0583
326424002917	Helix-turn-helix domains; Region: HTH; cl00088
326424002918	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_6; cd08423
326424002919	putative dimerization interface [polypeptide binding]; other site
326424002920	putative molybdopterin-guanine dinucleotide biosynthesis protein MobB/unknown domain fusion protein; Provisional; Region: PRK14495
326424002921	Hydrolase of X-linked nucleoside diphosphate N terminal; Region: Nudix_N; pfam12535
326424002922	Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_14; cd04672
326424002923	nudix motif; other site
326424002924	HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the basis...; Region: HIT_like; cl00228
326424002925	Dyp-type peroxidase family; Region: Dyp_perox; cl01067
326424002926	Imelysin; Region: Peptidase_M75; cl09159
326424002927	Iron permease FTR1 family; Region: FTR1; cl00475
326424002928	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883
326424002929	nudix motif; other site
326424002930	Predicted enolase-phosphatase [Energy production and conversion]; Region: COG4229
326424002931	Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391
326424002932	Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1791
326424002933	Cupin domain; Region: Cupin_2; cl09118
326424002934	methylthioribose-1-phosphate isomerase; Reviewed; Region: mtnA; PRK05720
326424002935	Predicted translation initiation factor 2B subunit, eIF-2B alpha/beta/delta family [Translation, ribosomal structure and biogenesis]; Region: COG0182; cl00348
326424002936	Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cl00214
326424002937	Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cl00200
326424002938	amphipathic channel; other site
326424002939	Asn-Pro-Ala signature motifs; other site
326424002940	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167
326424002941	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
326424002942	DNA-binding site [nucleotide binding]; DNA binding site
326424002943	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
326424002944	pyridoxal 5'-phosphate binding site [chemical binding]; other site
326424002945	homodimer interface [polypeptide binding]; other site
326424002946	catalytic residue [active]
326424002947	Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cl11424
326424002948	Predicted amidohydrolase [General function prediction only]; Region: COG0388
326424002949	active site
326424002950	catalytic triad [active]
326424002951	dimer interface [polypeptide binding]; other site
326424002952	phenylhydantoinase; Validated; Region: PRK08323
326424002953	D-hydantoinases (D-HYD) also called dihydropyrimidases (DHPase) and related proteins; DHPases are a family of enzymes that catalyze the reversible hydrolytic ring opening of the amide bond in five- or six-membered cyclic diamides, like dihydropyrimidine...; Region: D-HYD; cd01314
326424002954	tetramer interface [polypeptide binding]; other site
326424002955	active site
326424002956	Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085
326424002957	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
326424002958	tetrameric interface [polypeptide binding]; other site
326424002959	NAD binding site [chemical binding]; other site
326424002960	catalytic residues [active]
326424002961	F420-dependent oxidoreductase, CPS_4043 family; Region: F420_CPS_4043; TIGR03842
326424002962	N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097
326424002963	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
326424002964	dimer interface [polypeptide binding]; other site
326424002965	conserved gate region; other site
326424002966	putative PBP binding loops; other site
326424002967	ABC-ATPase subunit interface; other site
326424002968	ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116
326424002969	NrtD and SsuB are the ATP-binding subunits of the bacterial ABC-type nitrate and sulfonate transport systems, respectively.  ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars; Region: ABC_NrtD_SsuB_transporters; cd03293
326424002970	Walker A/P-loop; other site
326424002971	ATP binding site [chemical binding]; other site
326424002972	Q-loop/lid; other site
326424002973	ABC transporter signature motif; other site
326424002974	Walker B; other site
326424002975	D-loop; other site
326424002976	H-loop/switch region; other site
326424002977	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427
326424002978	NMT1/THI5 like; Region: NMT1; pfam09084
326424002979	NMT1-like family; Region: NMT1_2; cl15260
326424002980	hypothetical protein; Provisional; Region: PRK06062
326424002981	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
326424002982	inhibitor-cofactor binding pocket; inhibition site
326424002983	pyridoxal 5'-phosphate binding site [chemical binding]; other site
326424002984	catalytic residue [active]
326424002985	Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409
326424002986	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
326424002987	Helix-turn-helix domains; Region: HTH; cl00088
326424002988	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
326424002989	NAD(P) binding site [chemical binding]; other site
326424002990	active site
326424002991	Trans-Isoprenyl Diphosphate Synthases, head-to-head; Region: Trans_IPPS_HH; cd00683
326424002992	active site lid residues [active]
326424002993	substrate binding pocket [chemical binding]; other site
326424002994	catalytic residues [active]
326424002995	substrate-Mg2+ binding site; other site
326424002996	aspartate-rich region 1; other site
326424002997	aspartate-rich region 2; other site
326424002998	Isoprenoid Biosynthesis enzymes, Class 1; Region: Isoprenoid_Biosyn_C1; cl00210
326424002999	squalene-associated FAD-dependent desaturase; Region: HpnE; TIGR03467
326424003000	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
326424003001	Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685
326424003002	substrate binding pocket [chemical binding]; other site
326424003003	chain length determination region; other site
326424003004	substrate-Mg2+ binding site; other site
326424003005	catalytic residues [active]
326424003006	aspartate-rich region 1; other site
326424003007	active site lid residues [active]
326424003008	aspartate-rich region 2; other site
326424003009	Squalene cyclase (SQCY) domain subgroup 1; found in class II terpene cyclases that have an alpha 6 - alpha 6 barrel fold. Squalene cyclase (SQCY)  and 2,3-oxidosqualene cyclase (OSQCY) are integral membrane proteins that catalyze a cationic cyclization...; Region: SQCY_1; cd02892
326424003010	squalene-hopene cyclase; Region: hopene_cyclase; TIGR01507
326424003011	Active site cavity [active]
326424003012	catalytic acid [active]
326424003013	Phosphorylase superfamily; Region: PNP_UDP_1; cl00303
326424003014	LytB protein; Region: LYTB; cl00507
326424003015	(E)-4-hydroxy-3-methyl-but-2-enyl pyrophosphate reductase (IPP and DMAPP forming); Region: ispH_lytB; TIGR00216
326424003016	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
326424003017	CoenzymeA binding site [chemical binding]; other site
326424003018	subunit interaction site [polypeptide binding]; other site
326424003019	PHB binding site; other site
326424003020	hopanoid biosynthesis associated radical SAM protein HpnH; Region: HpnH; TIGR03470
326424003021	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
326424003022	FeS/SAM binding site; other site
326424003023	Domain of unknown function (DUF3463); Region: DUF3463; pfam11946
326424003024	DNA-binding transcriptional regulator EnvR; Provisional; Region: PRK09975
326424003025	Helix-turn-helix domains; Region: HTH; cl00088
326424003026	hopene-associated glycosyltransferase HpnB; Region: HpnB; TIGR03469
326424003027	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
326424003028	active site
326424003029	UreD urease accessory protein; Region: UreD; cl00530
326424003030	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761
326424003031	Urease accessory protein UreF [Posttranslational modification, protein turnover, chaperones]; Region: UreF; COG0830
326424003032	2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy; cl15773
326424003033	urease subunit alpha; Reviewed; Region: ureC; PRK13206
326424003034	Urease alpha-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, fungi and plants. Their primary role is to allow the use of...; Region: Urease_alpha; cd00375
326424003035	subunit interactions [polypeptide binding]; other site
326424003036	active site
326424003037	flap region; other site
326424003038	Urease beta-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use of...; Region: Urease_beta; cd00407
326424003039	gamma-beta subunit interface [polypeptide binding]; other site
326424003040	alpha-beta subunit interface [polypeptide binding]; other site
326424003041	Urease gamma-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use...; Region: Urease_gamma; cd00390
326424003042	alpha-gamma subunit interface [polypeptide binding]; other site
326424003043	beta-gamma subunit interface [polypeptide binding]; other site
326424003044	NMT1/THI5 like; Region: NMT1; pfam09084
326424003045	ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116
326424003046	NrtD and SsuB are the ATP-binding subunits of the bacterial ABC-type nitrate and sulfonate transport systems, respectively.  ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars; Region: ABC_NrtD_SsuB_transporters; cd03293
326424003047	Walker A/P-loop; other site
326424003048	ATP binding site [chemical binding]; other site
326424003049	Q-loop/lid; other site
326424003050	ABC transporter signature motif; other site
326424003051	Walker B; other site
326424003052	D-loop; other site
326424003053	H-loop/switch region; other site
326424003054	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427
326424003055	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427
326424003056	Adenine deaminase [Nucleotide transport and metabolism]; Region: AdeC; COG1001
326424003057	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
326424003058	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
326424003059	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
326424003060	Predicted transcriptional regulator containing an HTH domain and an uncharacterized domain shared with the mammalian protein Schlafen [Transcription]; Region: COG2865
326424003061	ATP-dependent DNA helicase recG C-terminal; Region: HATPase_c_4; pfam13749
326424003062	Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469
326424003063	[2Fe-2S] cluster binding site [ion binding]; other site
326424003064	START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643
326424003065	hydrophobic ligand binding site; other site
326424003066	FAD binding domain in molybdopterin dehydrogenase; Region: FAD_binding_5; pfam00941
326424003067	CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; cl08390
326424003068	[2Fe-2S] binding domain; Region: Fer2_2; pfam01799
326424003069	xanthine dehydrogenase D subunit; Region: pucD; TIGR03196
326424003070	Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; cl03161
326424003071	Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738
326424003072	allantoinase; Region: allantoinase; TIGR03178
326424003073	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
326424003074	active site
326424003075	putative bifunctional allantoicase/OHCU decarboxylase; Provisional; Region: PRK13797
326424003076	Allantoicase repeat; Region: Allantoicase; pfam03561
326424003077	Allantoicase repeat; Region: Allantoicase; pfam03561
326424003078	OHCU decarboxylase; Region: OHCU_decarbox; cl01251
326424003079	HIUase (5-hydroxyisourate hydrolase) catalyzes the second step in a three-step ureide pathway in which 5-hydroxyisourate (HIU), a product of the uricase (urate oxidase) reaction, is hydrolyzed to 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline (OHCU); Region: TLP_HIUase; cd05822
326424003080	active site
326424003081	homotetramer interface [polypeptide binding]; other site
326424003082	Protein of unknown function (DUF3349); Region: DUF3349; pfam11829
326424003083	Phosphate transporter family; Region: PHO4; cl00396
326424003084	Pyruvate kinase (PK):  Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl09155
326424003085	Helix-turn-helix domains; Region: HTH; cl00088
326424003086	Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909
326424003087	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_22; cd08359
326424003088	putative dimer interface [polypeptide binding]; other site
326424003089	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
326424003090	[FeFe] hydrogenase, group B1/B3; Region: FeFe_hydrog_B1; TIGR04105
326424003091	4Fe-4S binding domain; Region: Fer4; cl02805
326424003092	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
326424003093	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
326424003094	Amidohydrolase; Region: Amidohydro_4; pfam13147
326424003095	active site
326424003096	Helix-turn-helix domains; Region: HTH; cl00088
326424003097	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
326424003098	dimerization interface [polypeptide binding]; other site
326424003099	Bacterioferritin (cytochrome b1) [Inorganic ion transport and metabolism]; Region: Bfr; COG2193
326424003100	Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cl00264
326424003101	dinuclear metal binding motif [ion binding]; other site
326424003102	Adenosine deaminase [Nucleotide transport and metabolism]; Region: Add; COG1816
326424003103	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
326424003104	active site
326424003105	hydroxydechloroatrazine ethylaminohydrolase; Reviewed; Region: PRK08203
326424003106	TRZ/ATZ family contains enzymes from the atrazine degradation pathway and related hydrolases. Atrazine, a chlorinated herbizide, can be catabolized by a variety of different bacteria. The first three steps of the atrazine dehalogenation pathway are...; Region: ATZ_TRZ_like; cd01298
326424003107	active site
326424003108	putative substrate binding pocket [chemical binding]; other site
326424003109	RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; cl06870
326424003110	SpoU rRNA Methylase family; Region: SpoU_methylase; cl00362
326424003111	SpoU rRNA Methylase family; Region: SpoU_methylase; cl00362
326424003112	Protein of unknown function (DUF2752); Region: DUF2752; pfam10825
326424003113	OpgC protein; Region: OpgC_C; cl00792
326424003114	Periplasmic binding protein; Region: Peripla_BP_6; pfam13458
326424003115	Type I periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type active transport systems that are predicted to be involved in transport of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_7; cd06341
326424003116	putative ligand binding site [chemical binding]; other site
326424003117	ABC transporter, ATP-binding subunit, PQQ-dependent alcohol dehydrogenase system; Region: PQQ_ABC_ATP; TIGR03864
326424003118	LivF (TM1139) is part of the LIV-I bacterial ABC-type two-component transport system that imports neutral, branched-chain amino acids.  The  E. coli branched-chain amino acid transporter comprises a heterodimer of ABC transporters (LivF and LivG), a...; Region: ABC_TM1139_LivF_branched; cd03224
326424003119	Walker A/P-loop; other site
326424003120	ATP binding site [chemical binding]; other site
326424003121	Q-loop/lid; other site
326424003122	ABC transporter signature motif; other site
326424003123	Walker B; other site
326424003124	D-loop; other site
326424003125	H-loop/switch region; other site
326424003126	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411
326424003127	The Mj1267/LivG ABC transporter subfamily is involved in the transport of the hydrophobic amino acids leucine, isoleucine and valine.  MJ1267 is a branched-chain amino acid transporter with 29% similarity to both the LivF and LivG components of the E; Region: ABC_Mj1267_LivG_branched; cd03219
326424003128	Walker A/P-loop; other site
326424003129	ATP binding site [chemical binding]; other site
326424003130	Q-loop/lid; other site
326424003131	ABC transporter signature motif; other site
326424003132	Walker B; other site
326424003133	D-loop; other site
326424003134	H-loop/switch region; other site
326424003135	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
326424003136	TM-ABC transporter signature motif; other site
326424003137	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
326424003138	TM-ABC transporter signature motif; other site
326424003139	UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087
326424003140	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
326424003141	NAD(P) binding site [chemical binding]; other site
326424003142	active site
326424003143	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
326424003144	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
326424003145	non-specific DNA binding site [nucleotide binding]; other site
326424003146	salt bridge; other site
326424003147	sequence-specific DNA binding site [nucleotide binding]; other site
326424003148	Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570
326424003149	active site
326424003150	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883
326424003151	nudix motif; other site
326424003152	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447
326424003153	ATP-dependent Clp protease adaptor protein ClpS; Region: ClpS; cl00933
326424003154	Domain of unknown function (DUF2017); Region: DUF2017; pfam09438
326424003155	Mpr1p, Pad1p N-terminal (MPN) domains with catalytic isopeptidase activity (metal-binding); Region: MPN_like; cd08070
326424003156	MPN+ (JAMM) motif; other site
326424003157	Zinc-binding site [ion binding]; other site
326424003158	Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754
326424003159	MoaE interaction surface [polypeptide binding]; other site
326424003160	MoeB interaction surface [polypeptide binding]; other site
326424003161	thiocarboxylated glycine; other site
326424003162	Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031
326424003163	CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561
326424003164	dimer interface [polypeptide binding]; other site
326424003165	pyridoxal 5'-phosphate binding site [chemical binding]; other site
326424003166	catalytic residue [active]
326424003167	NTPase/HAM1.  This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515
326424003168	active site
326424003169	dimerization interface [polypeptide binding]; other site
326424003170	RNase PH-like 3'-5' exoribonucleases; Region: RNase_PH; cl03114
326424003171	oligomer interface [polypeptide binding]; other site
326424003172	RNA binding site [nucleotide binding]; other site
326424003173	Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446
326424003174	Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518
326424003175	3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084
326424003176	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
326424003177	Antibiotic biosynthesis monooxygenase; Region: ABM; cl10022
326424003178	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447
326424003179	nudix motif; other site
326424003180	Helix-turn-helix domains; Region: HTH; cl00088
326424003181	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; cl12078
326424003182	RNA polymerase sigma factor; Provisional; Region: PRK12524
326424003183	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761
326424003184	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
326424003185	Esterase-like activity of phytase; Region: Phytase-like; pfam13449
326424003186	Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415
326424003187	Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540
326424003188	Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540
326424003189	Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415
326424003190	Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415
326424003191	Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540
326424003192	Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415
326424003193	Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415
326424003194	Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540
326424003195	Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415
326424003196	Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017
326424003197	catalytic triad [active]
326424003198	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
326424003199	DoxX; Region: DoxX; cl00976
326424003200	SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968
326424003201	Cu(I) binding site [ion binding]; other site
326424003202	Protein of unknown function (DUF3618); Region: DUF3618; pfam12277
326424003203	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
326424003204	catalytic core [active]
326424003205	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075
326424003206	Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320
326424003207	oligomerisation interface [polypeptide binding]; other site
326424003208	mobile loop; other site
326424003209	roof hairpin; other site
326424003210	Domain of unknown function (DUF4193); Region: DUF4193; pfam13834
326424003211	ATP-dependent transcriptional regulator [Transcription]; Region: MalT; COG2909
326424003212	transcriptional regulator MalT; Provisional; Region: PRK04841
326424003213	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
326424003214	DNA binding residues [nucleotide binding]
326424003215	dimerization interface [polypeptide binding]; other site
326424003216	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
326424003217	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
326424003218	DNA binding residues [nucleotide binding]
326424003219	dimerization interface [polypeptide binding]; other site
326424003220	Dioxygenases related to 2-nitropropane dioxygenase [General function prediction only]; Region: COG2070
326424003221	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl09108
326424003222	phosphate binding site [ion binding]; other site
326424003223	3-oxoacyl-(acyl-carrier-protein) synthase [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: FabB; COG0304
326424003224	polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833
326424003225	active site
326424003226	Acyl transferase domain; Region: Acyl_transf_1; cl08282
326424003227	malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128
326424003228	polyketide-type polyunsaturated fatty acid synthase PfaA; Region: omega_3_PfaA; TIGR02813
326424003229	polyketide-type polyunsaturated fatty acid synthase PfaA; Region: omega_3_PfaA; TIGR02813
326424003230	ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953
326424003231	putative NADP binding site [chemical binding]; other site
326424003232	active site
326424003233	polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833
326424003234	beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150
326424003235	active site
326424003236	Acyl transferase domain; Region: Acyl_transf_1; cl08282
326424003237	polyketide-type polyunsaturated fatty acid synthase PfaA; Region: omega_3_PfaA; TIGR02813
326424003238	Phosphopantetheinyl transferase [Coenzyme metabolism]; Region: Sfp; COG2091
326424003239	4'-phosphopantetheinyl transferase superfamily; Region: ACPS; cl00500
326424003240	Phosphopantetheine attachment site; Region: PP-binding; cl09936
326424003241	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
326424003242	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
326424003243	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
326424003244	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
326424003245	Heme oxygenase catalyzes the rate limiting step in the degradation of heme to bilirubin, it is essential for recycling of iron from heme. Heme is used as a substrate and cofactor for its own degradation to biliverdin, iron, and carbon monoxide. This...; Region: HemeO; cl15243
326424003246	NMT1/THI5 like; Region: NMT1; pfam09084
326424003247	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
326424003248	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
326424003249	dimer interface [polypeptide binding]; other site
326424003250	conserved gate region; other site
326424003251	putative PBP binding loops; other site
326424003252	ABC-ATPase subunit interface; other site
326424003253	ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116
326424003254	NrtD and SsuB are the ATP-binding subunits of the bacterial ABC-type nitrate and sulfonate transport systems, respectively.  ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars; Region: ABC_NrtD_SsuB_transporters; cd03293
326424003255	Walker A/P-loop; other site
326424003256	ATP binding site [chemical binding]; other site
326424003257	Q-loop/lid; other site
326424003258	ABC transporter signature motif; other site
326424003259	Walker B; other site
326424003260	D-loop; other site
326424003261	H-loop/switch region; other site
326424003262	Domain of unknown function (DUF4095); Region: DUF4095; pfam13338
326424003263	Domain of unknown function DUF87; Region: DUF87; pfam01935
326424003264	AAA-like domain; Region: AAA_10; pfam12846
326424003265	L,D-transpeptidase catalytic domain; Region: YkuD; cl15405
326424003266	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
326424003267	Predicted 6-phosphogluconate dehydrogenase [Carbohydrate transport and metabolism]; Region: Gnd; COG1023
326424003268	mercuric reductase; Validated; Region: PRK06370
326424003269	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
326424003270	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
326424003271	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
326424003272	Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578
326424003273	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
326424003274	active site
326424003275	pimeloyl-CoA dehydrogenase, small subunit; Region: pimD_small; TIGR03203
326424003276	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
326424003277	active site
326424003278	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585
326424003279	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075
326424003280	Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578
326424003281	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
326424003282	Helix-turn-helix domains; Region: HTH; cl00088
326424003283	FAD binding domain; Region: FAD_binding_4; pfam01565
326424003284	FAD linked oxidases, C-terminal domain; Region: FAD-oxidase_C; pfam02913
326424003285	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
326424003286	NAD(P) binding site [chemical binding]; other site
326424003287	Protein of unknown function (DUF2993); Region: DUF2993; pfam11209
326424003288	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cl00062
326424003289	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cl00062
326424003290	The Eye Pigment Precursor Transporter (EPP) Family protein; Region: 3a01204; TIGR00955
326424003291	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
326424003292	ABC-2 type transporter; Region: ABC2_membrane; cl11417
326424003293	Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277
326424003294	putative active site [active]
326424003295	Catalytic domain of Protein Kinases; Region: PKc; cd00180
326424003296	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
326424003297	active site
326424003298	ATP binding site [chemical binding]; other site
326424003299	substrate binding site [chemical binding]; other site
326424003300	activation loop (A-loop); other site
326424003301	tol-pal system beta propeller repeat protein TolB; Region: propeller_TolB; TIGR02800
326424003302	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
326424003303	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
326424003304	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
326424003305	active site
326424003306	Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer,  utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514
326424003307	hypothetical protein; Provisional; Region: PRK07877
326424003308	dimer interface [polypeptide binding]; other site
326424003309	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786
326424003310	endonuclease III; Region: ENDO3c; smart00478
326424003311	minor groove reading motif; other site
326424003312	helix-hairpin-helix signature motif; other site
326424003313	active site
326424003314	Superfamily I DNA and RNA helicases [General function prediction only]; Region: COG3973
326424003315	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
326424003316	Superfamily I DNA and RNA helicases [General function prediction only]; Region: COG3973
326424003317	Family description; Region: UvrD_C_2; cl15862
326424003318	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_8; cd07246
326424003319	putative dimer interface [polypeptide binding]; other site
326424003320	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
326424003321	FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277
326424003322	FAD binding domain; Region: FAD_binding_4; pfam01565
326424003323	Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247
326424003324	Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247
326424003325	dolichyl-phosphate beta-D-mannosyltransferase; Region: PLN02726
326424003326	DPM1_like represents putative enzymes similar to eukaryotic DPM1; Region: DPM1_like; cd06442
326424003327	Ligand binding site; other site
326424003328	Putative Catalytic site; other site
326424003329	DXD motif; other site
326424003330	PA14 domain; Region: PA14; cl08459
326424003331	PA14 domain; Region: PA14; cl08459
326424003332	PA14 domain; Region: PA14; cl08459
326424003333	Glyoxal oxidase N-terminus; Region: Glyoxal_oxid_N; pfam07250
326424003334	C-terminal Early set domain associated with the catalytic domain of galactose oxidase; Region: E_set_GO_C; cd02851
326424003335	SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968
326424003336	Cu(I) binding site [ion binding]; other site
326424003337	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
326424003338	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
326424003339	active site
326424003340	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
326424003341	phosphopeptide binding site; other site
326424003342	Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467
326424003343	iron-sulfur cluster [ion binding]; other site
326424003344	[2Fe-2S] cluster binding site [ion binding]; other site
326424003345	aminopeptidase N, Streptomyces lividans type; Region: pepN_strep_liv; TIGR02412
326424003346	Peptidase M1 family containing Aminopeptidase N; Region: M1_APN_3; cd09602
326424003347	Zn binding site [ion binding]; other site
326424003348	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
326424003349	dimerization interface [polypeptide binding]; other site
326424003350	putative DNA binding site [nucleotide binding]; other site
326424003351	putative Zn2+ binding site [ion binding]; other site
326424003352	Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109
326424003353	F420-dependent oxidoreductase, MSMEG_4879 family; Region: F420_MSMEG_4879; TIGR03564
326424003354	Uncharacterized protein family (UPF0014); Region: UPF0014; cl00424
326424003355	Domain of unknown function (DUF385); Region: DUF385; cl04387
326424003356	Protein of unknown function (DUF1006); Region: DUF1006; cl15826
326424003357	Transcription factor zinc-finger; Region: zf-TFIIB; cl01565
326424003358	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
326424003359	substrate binding site [chemical binding]; other site
326424003360	Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane]; Region: Cfa; COG2230
326424003361	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
326424003362	S-adenosylmethionine binding site [chemical binding]; other site
326424003363	Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381
326424003364	Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr; Region: PTPc; cl00053
326424003365	active site
326424003366	Helix-turn-helix domains; Region: HTH; cl00088
326424003367	NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252
326424003368	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
326424003369	Pentapeptide repeats containing protein [Function unknown]; Region: COG1357
326424003370	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
326424003371	UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087
326424003372	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
326424003373	NAD(P) binding site [chemical binding]; other site
326424003374	active site
326424003375	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
326424003376	dimer interface [polypeptide binding]; other site
326424003377	phosphorylation site [posttranslational modification]
326424003378	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
326424003379	ATP binding site [chemical binding]; other site
326424003380	Mg2+ binding site [ion binding]; other site
326424003381	G-X-G motif; other site
326424003382	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
326424003383	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
326424003384	active site
326424003385	phosphorylation site [posttranslational modification]
326424003386	intermolecular recognition site; other site
326424003387	dimerization interface [polypeptide binding]; other site
326424003388	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
326424003389	DNA binding site [nucleotide binding]
326424003390	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
326424003391	active site
326424003392	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
326424003393	Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199
326424003394	Moco binding site; other site
326424003395	metal coordination site [ion binding]; other site
326424003396	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
326424003397	Helix-turn-helix domains; Region: HTH; cl00088
326424003398	FOG: CBS domain [General function prediction only]; Region: COG0517
326424003399	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_9; cd04622
326424003400	Domain of unknown function (DUF1918); Region: DUF1918; pfam08940
326424003401	Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064
326424003402	D-arabinose dehydrogenase; Region: arabinose_DH_like; cd05284
326424003403	NAD binding site [chemical binding]; other site
326424003404	substrate binding site [chemical binding]; other site
326424003405	catalytic Zn binding site [ion binding]; other site
326424003406	structural Zn binding site [ion binding]; other site
326424003407	S-adenosyl methyltransferase; Region: Methyltransf_19; pfam04672
326424003408	PAS domain S-box; Region: sensory_box; TIGR00229
326424003409	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
326424003410	putative active site [active]
326424003411	heme pocket [chemical binding]; other site
326424003412	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
326424003413	metal binding site [ion binding]; metal-binding site
326424003414	active site
326424003415	I-site; other site
326424003416	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
326424003417	long-chain-fatty-acid--CoA ligase; Validated; Region: PRK08276
326424003418	AMP-binding enzyme; Region: AMP-binding; cl15778
326424003419	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
326424003420	enoyl-CoA hydratase; Provisional; Region: PRK06190
326424003421	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
326424003422	substrate binding site [chemical binding]; other site
326424003423	oxyanion hole (OAH) forming residues; other site
326424003424	trimer interface [polypeptide binding]; other site
326424003425	MOSC domain; Region: MOSC; pfam03473
326424003426	START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643
326424003427	hydrophobic ligand binding site; other site
326424003428	Low molecular weight phosphatase family; Region: LMWPc; cl00105
326424003429	Low molecular weight phosphotyrosine protein phosphatase; Region: LMWPc; pfam01451
326424003430	active site
326424003431	Predicted sugar phosphatases of the HAD superfamily [Carbohydrate transport and metabolism]; Region: NagD; COG0647
326424003432	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
326424003433	active site
326424003434	motif I; other site
326424003435	motif II; other site
326424003436	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
326424003437	Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109
326424003438	Helix-turn-helix domains; Region: HTH; cl00088
326424003439	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
326424003440	Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378
326424003441	substrate binding site [chemical binding]; other site
326424003442	oxyanion hole (OAH) forming residues; other site
326424003443	trimer interface [polypeptide binding]; other site
326424003444	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
326424003445	DNA binding residues [nucleotide binding]
326424003446	dimerization interface [polypeptide binding]; other site
326424003447	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
326424003448	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
326424003449	DNA binding residues [nucleotide binding]
326424003450	dimerization interface [polypeptide binding]; other site
326424003451	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
326424003452	Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771
326424003453	Acyl-CoA dehydrogenase; Region: ACAD; cd00567
326424003454	Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109
326424003455	Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109
326424003456	acyl-CoA synthetase; Validated; Region: PRK06188
326424003457	AMP-binding enzyme; Region: AMP-binding; cl15778
326424003458	Flavin Reductases; Region: FlaRed; cl00801
326424003459	NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961
326424003460	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
326424003461	NAD(P) binding site [chemical binding]; other site
326424003462	catalytic residues [active]
326424003463	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
326424003464	Acyl-CoA dehydrogenase; Region: ACAD; cd00567
326424003465	active site
326424003466	3-methylcrotonyl-CoA carboxylase, beta chain; Region: PLN02820
326424003467	Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl15772
326424003468	Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770
326424003469	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
326424003470	ATP-grasp domain; Region: ATP-grasp_4; cl03087
326424003471	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; cl08365
326424003472	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
326424003473	carboxyltransferase (CT) interaction site; other site
326424003474	biotinylation site [posttranslational modification]; other site
326424003475	enoyl-CoA hydratase; Provisional; Region: PRK06494
326424003476	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
326424003477	substrate binding site [chemical binding]; other site
326424003478	oxyanion hole (OAH) forming residues; other site
326424003479	trimer interface [polypeptide binding]; other site
326424003480	Protein of unknown function (DUF1446); Region: DUF1446; pfam07287
326424003481	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
326424003482	active site
326424003483	TOBE domain; Region: TOBE_2; cl01440
326424003484	TOBE domain; Region: TOBE_2; cl01440
326424003485	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
326424003486	NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370
326424003487	NAD(P) binding site [chemical binding]; other site
326424003488	active site
326424003489	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl09108
326424003490	phosphate binding site [ion binding]; other site
326424003491	polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833
326424003492	beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150
326424003493	active site
326424003494	malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128
326424003495	Acyl transferase domain; Region: Acyl_transf_1; cl08282
326424003496	polyketide-type polyunsaturated fatty acid synthase PfaA; Region: omega_3_PfaA; TIGR02813
326424003497	ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953
326424003498	putative NADP binding site [chemical binding]; other site
326424003499	active site
326424003500	Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826
326424003501	Virulence factor BrkB; Region: Virul_fac_BrkB; cl07918
326424003502	ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591
326424003503	FtsX-like permease family; Region: FtsX; cl15850
326424003504	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
326424003505	This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE).  They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255
326424003506	Walker A/P-loop; other site
326424003507	ATP binding site [chemical binding]; other site
326424003508	Q-loop/lid; other site
326424003509	ABC transporter signature motif; other site
326424003510	Walker B; other site
326424003511	D-loop; other site
326424003512	H-loop/switch region; other site
326424003513	NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604
326424003514	alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289
326424003515	putative NAD(P) binding site [chemical binding]; other site
326424003516	CHAT domain; Region: CHAT; pfam12770
326424003517	Rubredoxin-like zinc ribbon domain (DUF35_N); Region: DUF35_N; pfam12172
326424003518	DUF35 OB-fold domain; Region: DUF35; pfam01796
326424003519	lipid-transfer protein; Provisional; Region: PRK07855
326424003520	Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2  has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829
326424003521	active site
326424003522	Predicted aminoglycoside phosphotransferase [General function prediction only]; Region: COG3173
326424003523	Acyl-CoA dehydrogenase (ACAD) 10 and 11, N-terminal domain, and similar proteins. This subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: ACAD10_11_like; cd05154
326424003524	putative active site [active]
326424003525	putative substrate binding site [chemical binding]; other site
326424003526	ATP binding site [chemical binding]; other site
326424003527	Epoxide hydrolase N terminus; Region: EHN; pfam06441
326424003528	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
326424003529	mycofactocin system transcriptional regulator; Region: mycofact_TetR; TIGR03968
326424003530	Helix-turn-helix domains; Region: HTH; cl00088
326424003531	S-adenosyl methyltransferase; Region: Methyltransf_19; pfam04672
326424003532	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl15754
326424003533	S-adenosylmethionine binding site [chemical binding]; other site
326424003534	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
326424003535	Ligand Binding Site [chemical binding]; other site
326424003536	Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053
326424003537	Cation efflux family; Region: Cation_efflux; cl00316
326424003538	chaperonin GroEL; Reviewed; Region: groEL; PRK12849
326424003539	GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344
326424003540	ring oligomerisation interface [polypeptide binding]; other site
326424003541	ATP/Mg binding site [chemical binding]; other site
326424003542	stacking interactions; other site
326424003543	hinge regions; other site
326424003544	This family is most closely related to the GT1 family of glycosyltransferases. ORF704 in E. coli has been shown to be involved in the biosynthesis of O-specific mannose homopolysaccharides; Region: GT1_ecORF704_like; cd03822
326424003545	Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647
326424003546	active site
326424003547	This family is most closely related to the GT1 family of glycosyltransferases. aviGT4 in Streptomyces viridochromogenes has been shown to be involved in biosynthesis of oligosaccharide antibiotic avilamycin A. Inactivation of aviGT4 resulted in a mutant...; Region: GT1_AviGT4_like; cd03802
326424003548	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
326424003549	putative ADP-binding pocket [chemical binding]; other site
326424003550	Cupin domain; Region: Cupin_2; cl09118
326424003551	Helix-turn-helix domains; Region: HTH; cl00088
326424003552	Protein of unknown function (DUF2945); Region: DUF2945; pfam11160
326424003553	Predicted phosphatases [General function prediction only]; Region: Gph; COG0546
326424003554	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
326424003555	motif II; other site
326424003556	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
326424003557	Domain of unknown function (DUF4143); Region: DUF4143; pfam13635
326424003558	Antibiotic biosynthesis monooxygenase; Region: ABM; cl10022
326424003559	glycoside hydrolase family 64: laminaripentaose-producing, beta-1,3-glucanase (LPHase)-like; Region: GH64-LPHase-like; cd09216
326424003560	substrate binding pocket [chemical binding]; other site
326424003561	catalytic residues [active]
326424003562	GIY-YIG nuclease domain superfamily; Region: GIY-YIG_SF; cl15257
326424003563	Clavaminic acid synthetase (CAS) -like;  CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cl00184
326424003564	Uncharacterized protein conserved in archaea [Function unknown]; Region: COG4034
326424003565	Protein of unknown function (DUF1152); Region: DUF1152; pfam06626
326424003566	Transcriptional regulators [Transcription]; Region: PhnF; COG2188
326424003567	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
326424003568	DNA-binding site [nucleotide binding]; DNA binding site
326424003569	UTRA domain; Region: UTRA; cl01230
326424003570	Frankia paralogous domain; Region: Frankia_40_dom; TIGR03917
326424003571	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
326424003572	DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674
326424003573	Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600
326424003574	Frankia paralogous domain; Region: Frankia_40_dom; TIGR03917
326424003575	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
326424003576	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
326424003577	DNA binding site [nucleotide binding]
326424003578	active site
326424003579	Int/Topo IB signature motif; other site
326424003580	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
326424003581	ABC transporter transmembrane region; Region: ABC_membrane; cl00549
326424003582	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
326424003583	Walker A/P-loop; other site
326424003584	ATP binding site [chemical binding]; other site
326424003585	Q-loop/lid; other site
326424003586	ABC transporter signature motif; other site
326424003587	Walker B; other site
326424003588	D-loop; other site
326424003589	H-loop/switch region; other site
326424003590	ABC transporter transmembrane region; Region: ABC_membrane; cl00549
326424003591	ABC-type transport system involved in Fe-S cluster assembly, permease and ATPase components [Posttranslational modification, protein turnover, chaperones]; Region: ATM1; COG5265
326424003592	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
326424003593	Walker A/P-loop; other site
326424003594	ATP binding site [chemical binding]; other site
326424003595	Q-loop/lid; other site
326424003596	ABC transporter signature motif; other site
326424003597	Walker B; other site
326424003598	D-loop; other site
326424003599	H-loop/switch region; other site
326424003600	SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053
326424003601	active site
326424003602	catalytic triad [active]
326424003603	oxyanion hole [active]
326424003604	Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239
326424003605	phospholipase D alpha; Region: PLN02270
326424003606	putative active site [active]
326424003607	catalytic site [active]
326424003608	Catalytic domain, repeat 2, of vertebrate phospholipases, PLD1 and PLD2, and similar proteins; Region: PLDc_vPLD1_2_like_2; cd09105
326424003609	phospholipase D alpha; Region: PLN02270
326424003610	putative active site [active]
326424003611	catalytic site [active]
326424003612	Uncharacterized proteins involved in stress response, homologs of TerZ and putative cAMP-binding protein CABP1 [Signal transduction mechanisms]; Region: TerZ; COG2310
326424003613	Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974
326424003614	putative metal binding site [ion binding]; other site
326424003615	Protein of unknown function (DUF2510); Region: DUF2510; pfam10708
326424003616	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
326424003617	active site
326424003618	Catalytic NodB homology domain of uncharacterized bacterial polysaccharide deacetylases; Region: CE4_NodB_like_3; cd10959
326424003619	NodB motif; other site
326424003620	putative active site [active]
326424003621	putative catalytic site [active]
326424003622	putative Zn binding site [ion binding]; other site
326424003623	Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714
326424003624	Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377
326424003625	tetramer interface [polypeptide binding]; other site
326424003626	active site
326424003627	Mg2+/Mn2+ binding site [ion binding]; other site
326424003628	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
326424003629	NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961
326424003630	NAD(P) binding site [chemical binding]; other site
326424003631	catalytic residues [active]
326424003632	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
326424003633	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
326424003634	active site
326424003635	phosphorylation site [posttranslational modification]
326424003636	intermolecular recognition site; other site
326424003637	dimerization interface [polypeptide binding]; other site
326424003638	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
326424003639	DNA binding residues [nucleotide binding]
326424003640	dimerization interface [polypeptide binding]; other site
326424003641	TIR domain; Region: TIR_2; cl15770
326424003642	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200
326424003643	structural tetrad; other site
326424003644	TIR domain; Region: TIR_2; cl15770
326424003645	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200
326424003646	structural tetrad; other site
326424003647	Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600
326424003648	tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224
326424003649	phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189
326424003650	Int/Topo IB signature motif; other site
326424003651	DEDDh 3'-5' exonuclease domain of oligoribonuclease and similar proteins; Region: Orn; cd06135
326424003652	putative active site [active]
326424003653	putative substrate binding site [chemical binding]; other site
326424003654	catalytic site [active]
326424003655	dimer interface [polypeptide binding]; other site
326424003656	ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466
326424003657	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
326424003658	Subunit ChlI of Mg-chelatase; Region: ChlI; cl12214
326424003659	Pirin-related protein [General function prediction only]; Region: COG1741
326424003660	Cupin domain; Region: Cupin_2; cl09118
326424003661	Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726
326424003662	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
326424003663	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
326424003664	ligand binding site [chemical binding]; other site
326424003665	flexible hinge region; other site
326424003666	Helix-turn-helix domains; Region: HTH; cl00088
326424003667	HipA-like N-terminal domain; Region: HipA_N; pfam07805
326424003668	Protein of unknown function (DUF3037); Region: DUF3037; pfam11236
326424003669	Domain of unknown function (DUF3367); Region: DUF3367; pfam11847
326424003670	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
326424003671	Glycosyltransferase Family 4; Region: Glyco_transf_4; pfam13439
326424003672	GDP-mannose 4,6 dehydratase, extended (e) SDRs; Region: GDP_MD_SDR_e; cd05260
326424003673	GDP-mannose 4,6-dehydratase; Region: PLN02653
326424003674	NADP-binding site; other site
326424003675	homotetramer interface [polypeptide binding]; other site
326424003676	substrate binding site [chemical binding]; other site
326424003677	homodimer interface [polypeptide binding]; other site
326424003678	active site
326424003679	OpgC protein; Region: OpgC_C; cl00792
326424003680	SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053
326424003681	active site
326424003682	catalytic triad [active]
326424003683	oxyanion hole [active]
326424003684	Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl15769
326424003685	OpgC protein; Region: OpgC_C; cl00792
326424003686	30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06676
326424003687	S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec1_hs1; cd05687
326424003688	RNA binding site [nucleotide binding]; other site
326424003689	S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec2_hs2; cd04465
326424003690	RNA binding site [nucleotide binding]; other site
326424003691	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
326424003692	RNA binding site [nucleotide binding]; other site
326424003693	S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists of...; Region: S1_RPS1_repeat_hs4; cd05692
326424003694	RNA binding site [nucleotide binding]; other site
326424003695	Trm112p-like protein; Region: Trm112p; cl01066
326424003696	Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340
326424003697	catalytic residues [active]
326424003698	dimer interface [polypeptide binding]; other site
326424003699	Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305
326424003700	Transglutaminase-like superfamily; Region: Transglut_core; cl10469
326424003701	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
326424003702	NAD(P) binding site [chemical binding]; other site
326424003703	NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370
326424003704	active site
326424003705	Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977
326424003706	AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137
326424003707	conserved cys residue [active]
326424003708	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
326424003709	Domain of unknown function (DUF1772); Region: DUF1772; cl12097
326424003710	Cupin domain; Region: Cupin_2; cl09118
326424003711	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
326424003712	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
326424003713	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
326424003714	active site
326424003715	HIGH motif; other site
326424003716	nucleotide binding site [chemical binding]; other site
326424003717	lysyl-tRNA synthetase; Reviewed; Region: lysK; PRK00750
326424003718	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
326424003719	active site
326424003720	KMSKS motif; other site
326424003721	Glycosyl hydrolase family 26; Region: Glyco_hydro_26; cl09200
326424003722	MatE; Region: MatE; cl10513
326424003723	ABC transporter, ATP-binding subunit, PQQ-dependent alcohol dehydrogenase system; Region: PQQ_ABC_ATP; TIGR03864
326424003724	This family of ATP-binding proteins belongs to a multisubunit transporter involved in drug resistance (BcrA and DrrA), nodulation, lipid transport, and lantibiotic immunity.  In bacteria and archaea, these transporters usually include an ATP-binding...; Region: ABC_DR_subfamily_A; cd03230
326424003725	Walker A/P-loop; other site
326424003726	ATP binding site [chemical binding]; other site
326424003727	Q-loop/lid; other site
326424003728	ABC transporter signature motif; other site
326424003729	Walker B; other site
326424003730	D-loop; other site
326424003731	H-loop/switch region; other site
326424003732	ABC-2 type transporter; Region: ABC2_membrane; cl11417
326424003733	F420-dependent oxidoreductase, G6PDH family; Region: F420_G6P_family; TIGR03557
326424003734	N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097
326424003735	Predicted ATPase [General function prediction only]; Region: COG3910
326424003736	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
326424003737	Walker A/P-loop; other site
326424003738	ATP binding site [chemical binding]; other site
326424003739	ABC transporter signature motif; other site
326424003740	Walker B; other site
326424003741	D-loop; other site
326424003742	H-loop/switch region; other site
326424003743	Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane]; Region: Cfa; COG2230
326424003744	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
326424003745	S-adenosylmethionine binding site [chemical binding]; other site
326424003746	thiamine pyrophosphate protein; Provisional; Region: PRK08273
326424003747	Pyrimidine (PYR) binding domain of POX; Region: TPP_PYR_POX; cd07039
326424003748	PYR/PP interface [polypeptide binding]; other site
326424003749	tetramer interface [polypeptide binding]; other site
326424003750	dimer interface [polypeptide binding]; other site
326424003751	TPP binding site [chemical binding]; other site
326424003752	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; cl00815
326424003753	Thiamine pyrophosphate (TPP) family, Pyruvate oxidase (POX) subfamily, TPP-binding module; composed of proteins similar to Lactobacillus plantarum POX, which plays a key role in controlling acetate production under aerobic conditions. POX decarboxylates...; Region: TPP_POX; cd02014
326424003754	TPP-binding site [chemical binding]; other site
326424003755	Conserved hypothetical protein (DUF2461); Region: DUF2461; cl02374
326424003756	Choline/Carnitine o-acyltransferase; Region: Carn_acyltransf; pfam00755
326424003757	2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy; cl15773
326424003758	Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999
326424003759	Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482
326424003760	2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiH; COG0654
326424003761	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
326424003762	Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882
326424003763	Conserved hypothetical ATP binding protein; Region: ATP_bind_1; pfam03029
326424003764	G1 box; other site
326424003765	GTP/Mg2+ binding site [chemical binding]; other site
326424003766	G2 box; other site
326424003767	Switch I region; other site
326424003768	G3 box; other site
326424003769	Switch II region; other site
326424003770	G4 box; other site
326424003771	G5 box; other site
326424003772	Protein of unknown function (DUF742); Region: DUF742; pfam05331
326424003773	Roadblock/LC7 domain; Region: Robl_LC7; cl00886
326424003774	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
326424003775	ATP binding site [chemical binding]; other site
326424003776	Mg2+ binding site [ion binding]; other site
326424003777	G-X-G motif; other site
326424003778	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
326424003779	substrate binding site [chemical binding]; other site
326424003780	activation loop (A-loop); other site
326424003781	ATP-dependent DNA helicase RecQ; Region: recQ; TIGR01389
326424003782	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
326424003783	ATP binding site [chemical binding]; other site
326424003784	putative Mg++ binding site [ion binding]; other site
326424003785	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
326424003786	nucleotide binding region [chemical binding]; other site
326424003787	ATP-binding site [chemical binding]; other site
326424003788	RQC domain; Region: RQC; cl09632
326424003789	HRDC domain; Region: HRDC; cl02578
326424003790	Catalytic domain of Protein Kinases; Region: PKc; cd00180
326424003791	active site
326424003792	ATP binding site [chemical binding]; other site
326424003793	substrate binding site [chemical binding]; other site
326424003794	activation loop (A-loop); other site
326424003795	hydrogenase expression/formation protein HypE; Region: hypE; TIGR02124
326424003796	HypE (Hydrogenase expression/formation protein). HypE is involved in Ni-Fe hydrogenase biosynthesis.  HypE dehydrates its own carbamoyl moiety in an ATP-dependent process to yield the enzyme thiocyanate. The N-terminal domain of HypE is related to the...; Region: HypE; cd02197
326424003797	dimerization interface [polypeptide binding]; other site
326424003798	ATP binding site [chemical binding]; other site
326424003799	Hydrogenase formation hypA family; Region: HypD; cl12072
326424003800	Hydrogenase maturation factor [Posttranslational modification, protein turnover, chaperones]; Region: HypD; COG0409
326424003801	HupF/HypC family; Region: HupF_HypC; cl00394
326424003802	Acylphosphatase; Region: Acylphosphatase; cl00551
326424003803	[NiFe] hydrogenase maturation protein HypF; Region: hypF; TIGR00143
326424003804	HypF finger; Region: zf-HYPF; pfam07503
326424003805	HypF finger; Region: zf-HYPF; pfam07503
326424003806	Telomere recombination; Region: Sua5_yciO_yrdC; cl00305
326424003807	NHL repeat; Region: NHL; pfam01436
326424003808	Tetratricopeptide repeat; Region: TPR_12; pfam13424
326424003809	Hydrogenase specific C-terminal endopeptidases, also called Hydrogen Maturation Proteases (H2MP). These enzymes belong to the peptidase family M52. Maturation of [FeNi] hydrogenases includes formation of the nickel metallocenter, proteolytic processing...; Region: H2MP; cl00477
326424003810	nickel binding site [ion binding]; other site
326424003811	Nickel-dependent hydrogenase; Region: NiFeSe_Hases; cl00417
326424003812	NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; cl15792
326424003813	Hydrogenase expression/synthesis hypA family; Region: HypA; pfam01155
326424003814	hydrogenase nickel incorporation protein; Provisional; Region: hypA; cl00418
326424003815	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
326424003816	TIR domain; Region: TIR_2; cl15770
326424003817	OpgC protein; Region: OpgC_C; cl00792
326424003818	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
326424003819	Predicted oxidoreductases (related to aryl-alcohol dehydrogenases) [Energy production and conversion]; Region: Tas; COG0667
326424003820	active site
326424003821	catalytic tetrad [active]
326424003822	SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496
326424003823	dimer interface [polypeptide binding]; other site
326424003824	ssDNA binding site [nucleotide binding]; other site
326424003825	tetramer (dimer of dimers) interface [polypeptide binding]; other site
326424003826	Uncharacterized conserved protein [Function unknown]; Region: COG5361
326424003827	Protein of unknown function (DUF1254); Region: DUF1254; cl02257
326424003828	Protein of unknown function (DUF1214); Region: DUF1214; cl08447
326424003829	putative ABC transporter ATP-binding protein; Reviewed; Region: PRK11819
326424003830	ABCF_EF-3  Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth.  EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221
326424003831	ABCF_EF-3  Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth.  EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221
326424003832	ABC transporter; Region: ABC_tran_2; pfam12848
326424003833	ABCF_EF-3  Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth.  EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221
326424003834	Truncated hemoglobins (trHbs) are a family of oxygen-binding heme proteins found in cyanobacteria, eubacteria, unicellular eukaryotes, and plants. The truncated hemoglobins have a characteristic two-over-two alpha helical folding pattern that is distinct...; Region: Trunc_globin; cd00454
326424003835	apolar tunnel; other site
326424003836	heme binding site [chemical binding]; other site
326424003837	dimerization interface [polypeptide binding]; other site
326424003838	Alpha amylase catalytic domain found in oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), trehalose synthase (also called maltose alpha-D-glucosyltransferase), and related proteins; Region: AmyAc_OligoGlu_TS; cd11332
326424003839	active site
326424003840	catalytic site [active]
326424003841	GAF domain; Region: GAF_2; pfam13185
326424003842	GAF domain; Region: GAF; cl15785
326424003843	Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cl00120
326424003844	Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581
326424003845	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075
326424003846	Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702
326424003847	atypical (a) SDRs, subgroup 2; Region: SDR_a2; cd05245
326424003848	putative NAD(P) binding site [chemical binding]; other site
326424003849	putative active site [active]
326424003850	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
326424003851	active site
326424003852	Mechanosensitive ion channel; Region: MS_channel; pfam00924
326424003853	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
326424003854	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
326424003855	active site
326424003856	phosphorylation site [posttranslational modification]
326424003857	intermolecular recognition site; other site
326424003858	dimerization interface [polypeptide binding]; other site
326424003859	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
326424003860	DNA binding site [nucleotide binding]
326424003861	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054
326424003862	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
326424003863	dimer interface [polypeptide binding]; other site
326424003864	phosphorylation site [posttranslational modification]
326424003865	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
326424003866	ATP binding site [chemical binding]; other site
326424003867	Mg2+ binding site [ion binding]; other site
326424003868	G-X-G motif; other site
326424003869	4-alpha-glucanotransferase; Provisional; Region: malQ; PRK11052
326424003870	4-alpha-glucanotransferase; Region: Glyco_hydro_77; cl00711
326424003871	Repair protein; Region: Repair_PSII; cl01535
326424003872	Helix-turn-helix domains; Region: HTH; cl00088
326424003873	drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711
326424003874	aminopeptidase N, Streptomyces lividans type; Region: pepN_strep_liv; TIGR02412
326424003875	Peptidase M1 family containing Aminopeptidase N; Region: M1_APN_3; cd09602
326424003876	Zn binding site [ion binding]; other site
326424003877	pheromone autoinducer 2 transporter; Reviewed; Region: tqsA; cl00465
326424003878	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
326424003879	Ribose/Galactose Isomerase; Region: LacAB_rpiB; cl00485
326424003880	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
326424003881	active site
326424003882	Domain of unknown function (DUF3367); Region: DUF3367; pfam11847
326424003883	Domain of unknown function (DUF3367); Region: DUF3367; pfam11847
326424003884	RyR domain; Region: RyR; pfam02026
326424003885	Condensation domain; Region: Condensation; pfam00668
326424003886	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
326424003887	MatE; Region: MatE; cl10513
326424003888	Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244
326424003889	N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357
326424003890	Protein of unknown function (DUF1778); Region: DUF1778; cl01845
326424003891	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
326424003892	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
326424003893	active site
326424003894	catalytic tetrad [active]
326424003895	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
326424003896	The BcrA subfamily represents ABC transporters involved in peptide antibiotic resistance.  Bacitracin is a dodecapeptide antibiotic produced by B. licheniformis and B. subtilis.  The synthesis of bacitracin is non-ribosomally catalyzed by a multienzyme...; Region: ABC_BcrA_bacitracin_resist; cd03268
326424003897	Walker A/P-loop; other site
326424003898	ATP binding site [chemical binding]; other site
326424003899	Q-loop/lid; other site
326424003900	ABC transporter signature motif; other site
326424003901	Walker B; other site
326424003902	D-loop; other site
326424003903	H-loop/switch region; other site
326424003904	CHASE3 domain; Region: CHASE3; cl05000
326424003905	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054
326424003906	Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cl00120
326424003907	Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cl00120
326424003908	Protein of unknown function (DUF4230); Region: DUF4230; pfam14014
326424003909	Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318
326424003910	AMP-binding enzyme; Region: AMP-binding; cl15778
326424003911	Phosphopantetheine attachment site; Region: PP-binding; cl09936
326424003912	Thioesterase domains of type I polyketide synthases or non-ribosomal peptide synthetases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3319
326424003913	Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071
326424003914	Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain  (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464
326424003915	Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086
326424003916	putative phosphate binding site [ion binding]; other site
326424003917	putative catalytic site [active]
326424003918	active site
326424003919	metal binding site A [ion binding]; metal-binding site
326424003920	DNA binding site [nucleotide binding]
326424003921	putative AP binding site [nucleotide binding]; other site
326424003922	putative metal binding site B [ion binding]; other site
326424003923	Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cl00161
326424003924	Domain of Unknown Function (DUF1206); Region: DUF1206; pfam06724
326424003925	Domain of Unknown Function (DUF1206); Region: DUF1206; pfam06724
326424003926	enterobactin exporter EntS; Provisional; Region: PRK10489
326424003927	glutamine synthetase, type III; Region: gln_synth_III; TIGR03105
326424003928	Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120
326424003929	Glutamine amidotransferases class-II (GATase). The glutaminase domain catalyzes an amide nitrogen transfer from glutamine to the appropriate substrate. In this process, glutamine is hydrolyzed to glutamic acid and ammonia. This domain is related to...; Region: Gn_AT_II; cl00319
326424003930	active site
326424003931	Glutamine amidotransferase domain; Region: GATase_6; pfam13522
326424003932	GXGXG domain. This domain of unknown function is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS),  in subunit C of tungsten formylmethanofuran dehydrogenase (FwdC) and in subunit C of molybdenum formylmethanofuran...; Region: GXGXG; cl00239
326424003933	domain_subunit interface; other site
326424003934	Glutamate synthase (GltS) FMN-binding domain.  GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808
326424003935	Conserved region in glutamate synthase; Region: Glu_synthase; pfam01645
326424003936	active site
326424003937	FMN binding site [chemical binding]; other site
326424003938	substrate binding site [chemical binding]; other site
326424003939	3Fe-4S cluster binding site [ion binding]; other site
326424003940	FAD dependent oxidoreductase; Region: DAO; pfam01266
326424003941	N-methyltryptophan oxidase; Provisional; Region: solA; PRK11259
326424003942	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
326424003943	non-specific DNA binding site [nucleotide binding]; other site
326424003944	salt bridge; other site
326424003945	sequence-specific DNA binding site [nucleotide binding]; other site
326424003946	Cupin domain; Region: Cupin_2; cl09118
326424003947	Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071
326424003948	Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain  (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464
326424003949	putative dimer interface [polypeptide binding]; other site
326424003950	Predicted component of the type VI protein secretion system, contains a FHA domain [Intracellular trafficking, secretion, and vesicular    transport; Signal transduction mechanisms]; Region: COG3456
326424003951	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cl00062
326424003952	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
326424003953	phosphopeptide binding site; other site
326424003954	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
326424003955	ABCG transporters are involved in eye pigment (EP) precursor transport, regulation of lipid-trafficking mechanisms, and pleiotropic drug resistance (DR).  DR is a well-described phenomenon occurring in fungi and shares several similarities with processes...; Region: ABCG_EPDR; cd03213
326424003956	Walker A/P-loop; other site
326424003957	ATP binding site [chemical binding]; other site
326424003958	Q-loop/lid; other site
326424003959	ABC transporter signature motif; other site
326424003960	Walker B; other site
326424003961	D-loop; other site
326424003962	H-loop/switch region; other site
326424003963	ABC-2 type transporter; Region: ABC2_membrane; cl11417
326424003964	Protein of unknown function (DUF962); Region: DUF962; cl01879
326424003965	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
326424003966	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167
326424003967	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
326424003968	DNA-binding site [nucleotide binding]; DNA binding site
326424003969	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
326424003970	pyridoxal 5'-phosphate binding site [chemical binding]; other site
326424003971	homodimer interface [polypeptide binding]; other site
326424003972	catalytic residue [active]
326424003973	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
326424003974	Dihydroorotate dehydrogenase [Nucleotide transport and metabolism]; Region: PyrD; COG0167
326424003975	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl09108
326424003976	phosphate binding site [ion binding]; other site
326424003977	Domain of unknown function (DUF3291); Region: DUF3291; pfam11695
326424003978	L,D-transpeptidase catalytic domain; Region: YkuD; cl15405
326424003979	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
326424003980	trigger factor; Provisional; Region: tig; PRK01490
326424003981	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; cl11587
326424003982	Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698
326424003983	Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017
326424003984	Clp protease; Region: CLP_protease; pfam00574
326424003985	oligomer interface [polypeptide binding]; other site
326424003986	active site residues [active]
326424003987	ATP-dependent Clp protease proteolytic subunit; Reviewed; Region: PRK12553
326424003988	Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017
326424003989	oligomer interface [polypeptide binding]; other site
326424003990	active site residues [active]
326424003991	ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342
326424003992	ClpX C4-type zinc finger; Region: zf-C4_ClpX; cl05964
326424003993	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
326424003994	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
326424003995	Walker A motif; other site
326424003996	ATP binding site [chemical binding]; other site
326424003997	Walker B motif; other site
326424003998	arginine finger; other site
326424003999	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; cl11083
326424004000	folylpolyglutamate synthase/dihydrofolate synthase; Region: folC; TIGR01499
326424004001	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
326424004002	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
326424004003	Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285
326424004004	Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285
326424004005	Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413
326424004006	active site
326424004007	multimer interface [polypeptide binding]; other site
326424004008	rod shape-determining protein MreB; Provisional; Region: PRK13927
326424004009	Actin; An ubiquitous protein involved in the formation of filaments that are a major component of the cytoskeleton. Interaction with myosin provides the basis of muscular contraction and many aspects of cell motility. Each actin protomer binds one...; Region: ACTIN; cl11528
326424004010	ATP binding site [chemical binding]; other site
326424004011	profilin binding site; other site
326424004012	rod shape-determining protein MreC; Provisional; Region: PRK13922
326424004013	rod shape-determining protein MreC; Region: MreC; pfam04085
326424004014	rod shape-determining protein MreD; Region: MreD; cl01087
326424004015	penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423
326424004016	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
326424004017	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009
326424004018	Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511
326424004019	radical SAM family uncharacterized protein; Region: rSAM_fuse_unch; TIGR03960
326424004020	B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293
326424004021	B12 binding site [chemical binding]; other site
326424004022	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
326424004023	FeS/SAM binding site; other site
326424004024	radical SAM-linked protein; Region: sam_1_link_chp; TIGR03936
326424004025	Uncharacterized protein conserved in bacteria (DUF2344); Region: DUF2344; cl02090
326424004026	ribonuclease, Rne/Rng family; Region: RNaseEG; TIGR00757
326424004027	S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453
326424004028	homodimer interface [polypeptide binding]; other site
326424004029	oligonucleotide binding site [chemical binding]; other site
326424004030	Ribosomal prokaryotic L21 protein; Region: Ribosomal_L21p; cl00382
326424004031	Ribosomal L27 protein; Region: Ribosomal_L27; cl00359
326424004032	GTPase CgtA; Reviewed; Region: obgE; PRK12297
326424004033	GTP1/OBG; Region: GTP1_OBG; pfam01018
326424004034	Obg GTPase; Region: Obg; cd01898
326424004035	G1 box; other site
326424004036	GTP/Mg2+ binding site [chemical binding]; other site
326424004037	Switch I region; other site
326424004038	G2 box; other site
326424004039	G3 box; other site
326424004040	Switch II region; other site
326424004041	G4 box; other site
326424004042	G5 box; other site
326424004043	Domain of unknown function (DUF1967); Region: DUF1967; cl07779
326424004044	gamma-glutamyl kinase; Provisional; Region: PRK05429
326424004045	AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242
326424004046	nucleotide binding site [chemical binding]; other site
326424004047	homotetrameric interface [polypeptide binding]; other site
326424004048	putative phosphate binding site [ion binding]; other site
326424004049	putative allosteric binding site; other site
326424004050	PUA domain; Region: PUA; cl00607
326424004051	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
326424004052	Walker A/P-loop; other site
326424004053	ATP binding site [chemical binding]; other site
326424004054	Q-loop/lid; other site
326424004055	SbcCD and other Mre11/Rad50 (MR) complexes are implicated in the metabolism of DNA ends. They cleave ends sealed by hairpin structures and are thought to play a role in removing protein bound to DNA termini; Region: ABC_sbcCD; cd03279
326424004056	ABC transporter signature motif; other site
326424004057	Walker B; other site
326424004058	D-loop; other site
326424004059	H-loop/switch region; other site
326424004060	Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840
326424004061	active site
326424004062	metal binding site [ion binding]; metal-binding site
326424004063	DNA binding site [nucleotide binding]
326424004064	Type 5 capsule protein repressor C-terminal domain; Region: SbcD_C; pfam12320
326424004065	Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079
326424004066	gamma-glutamyl phosphate reductase; Region: proA; TIGR00407
326424004067	putative catalytic cysteine [active]
326424004068	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
326424004069	Walker A motif; other site
326424004070	ATP binding site [chemical binding]; other site
326424004071	Walker B motif; other site
326424004072	arginine finger; other site
326424004073	Protein containing von Willebrand factor type A (vWA) domain [General function prediction only]; Region: CoxE; COG3552
326424004074	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057
326424004075	OpgC protein; Region: OpgC_C; cl00792
326424004076	Acyltransferase family; Region: Acyl_transf_3; pfam01757
326424004077	phosphoglucomutase; Validated; Region: PRK07564
326424004078	The alpha-D-phosphohexomutase superfamily includes several related enzymes that catalyze a reversible intramolecular phosphoryl transfer on their sugar substrates. Members of this family include the phosphoglucomutases (PGM1 and PGM2), phosphoglucosamine...; Region: phosphohexomutase; cl03757
326424004079	active site
326424004080	substrate binding site [chemical binding]; other site
326424004081	metal binding site [ion binding]; metal-binding site
326424004082	nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071
326424004083	Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165
326424004084	active site
326424004085	(T/H)XGH motif; other site
326424004086	Oligomerisation domain; Region: Oligomerisation; cl00519
326424004087	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
326424004088	catalytic core [active]
326424004089	Protein of unknown function (DUF3494); Region: DUF3494; pfam11999
326424004090	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
326424004091	S-adenosylmethionine binding site [chemical binding]; other site
326424004092	Na+/H+ antiporter 1; Region: Na_H_antiport_1; cl01133
326424004093	The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509
326424004094	active site 2 [active]
326424004095	Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat1; cd03444
326424004096	catalytic triad [active]
326424004097	dimer interface [polypeptide binding]; other site
326424004098	AMP-binding enzyme; Region: AMP-binding; cl15778
326424004099	O-succinylbenzoate-CoA ligase; Region: menE; TIGR01923
326424004100	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
326424004101	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
326424004102	PAS domain; Region: PAS_9; pfam13426
326424004103	putative active site [active]
326424004104	heme pocket [chemical binding]; other site
326424004105	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
326424004106	metal binding site [ion binding]; metal-binding site
326424004107	active site
326424004108	I-site; other site
326424004109	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
326424004110	Helix-turn-helix domains; Region: HTH; cl00088
326424004111	Enoylreductase; Region: PKS_ER; smart00829
326424004112	Quinone oxidoreductase (QOR); Region: QOR1; cd08241
326424004113	NAD(P) binding site [chemical binding]; other site
326424004114	Protein of unknown function (DUF2630); Region: DUF2630; pfam10944
326424004115	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
326424004116	short chain dehydrogenase; Provisional; Region: PRK07062
326424004117	NAD(P) binding site [chemical binding]; other site
326424004118	active site
326424004119	Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819
326424004120	This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784
326424004121	active site
326424004122	TDP-binding site; other site
326424004123	acceptor substrate-binding pocket; other site
326424004124	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
326424004125	ligand binding site [chemical binding]; other site
326424004126	flexible hinge region; other site
326424004127	Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852
326424004128	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
326424004129	ATP binding site [chemical binding]; other site
326424004130	Mg2+ binding site [ion binding]; other site
326424004131	G-X-G motif; other site
326424004132	Response regulator receiver domain; Region: Response_reg; pfam00072
326424004133	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
326424004134	active site
326424004135	phosphorylation site [posttranslational modification]
326424004136	intermolecular recognition site; other site
326424004137	dimerization interface [polypeptide binding]; other site
326424004138	thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292
326424004139	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
326424004140	Poly(3-hydroxybutyrate) depolymerase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: LpqC; COG3509
326424004141	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200
326424004142	structural tetrad; other site
326424004143	Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446
326424004144	Uncharacterized subgroup of the nitrilase superfamily (putative class 13 nitrilases); Region: nitrilase_5; cd07583
326424004145	Predicted amidohydrolase [General function prediction only]; Region: COG0388
326424004146	putative active site [active]
326424004147	catalytic triad [active]
326424004148	putative dimer interface [polypeptide binding]; other site
326424004149	Ammonium Transporter Family; Region: Ammonium_transp; cl03012
326424004150	6-phosphofructokinase; Region: PLN02564
326424004151	Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381
326424004152	Helix-turn-helix domains; Region: HTH; cl00088
326424004153	Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909
326424004154	Major Facilitator Superfamily; Region: MFS_1; pfam07690
326424004155	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
326424004156	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
326424004157	Putative sensor; Region: Sensor; pfam13796
326424004158	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585
326424004159	Histidine kinase; Region: HisKA_3; pfam07730
326424004160	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075
326424004161	Mg2+ binding site [ion binding]; other site
326424004162	G-X-G motif; other site
326424004163	PAC2 family; Region: PAC2; cl00847
326424004164	hopanoid-associated sugar epimerase; Region: HpnA; TIGR03466
326424004165	uncharacterized subgroup of aldehyde reductase and flavonoid reductase related proteins, extended (e) SDRs; Region: AR_FR_like_1_SDR_e; cd05228
326424004166	putative NADP binding site [chemical binding]; other site
326424004167	putative substrate binding site [chemical binding]; other site
326424004168	active site
326424004169	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
326424004170	Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581
326424004171	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
326424004172	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
326424004173	active site
326424004174	3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK07819
326424004175	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
326424004176	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
326424004177	Membrane transport protein; Region: Mem_trans; cl09117
326424004178	Alkane hydroxylase is a bacterial, integral-membrane di-iron enzyme that shares a requirement for iron and oxygen for activity similar to that of the non-heme integral-membrane acyl coenzyme A (CoA) desaturases and acyl lipid desaturases. The alk genes...; Region: Alkane-hydroxylase; cd03512
326424004179	Di-iron ligands [ion binding]; other site
326424004180	Peptidase M50B-like; Region: Peptidase_M50B; pfam13398
326424004181	Uncharacterized ACR, COG2135; Region: DUF159; cl03646
326424004182	Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr; Region: PTPc; cl00053
326424004183	Protein of unknown function (DUF1271); Region: DUF1271; cl01443
326424004184	4Fe-4S single cluster domain; Region: Fer4_15; pfam13459
326424004185	YceI-like domain; Region: YceI; cl01001
326424004186	SLBB domain; Region: SLBB; pfam10531
326424004187	Helix-hairpin-helix motif; Region: HHH_3; pfam12836
326424004188	Competence protein; Region: Competence; cl00471
326424004189	Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446
326424004190	hypothetical protein; Reviewed; Region: PRK07914
326424004191	Ribosomal protein S20; Region: Ribosomal_S20p; cl00384
326424004192	GTP-binding protein LepA; Provisional; Region: PRK05433
326424004193	LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890
326424004194	G1 box; other site
326424004195	putative GEF interaction site [polypeptide binding]; other site
326424004196	GTP/Mg2+ binding site [chemical binding]; other site
326424004197	Switch I region; other site
326424004198	G2 box; other site
326424004199	G3 box; other site
326424004200	Switch II region; other site
326424004201	G4 box; other site
326424004202	G5 box; other site
326424004203	lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699
326424004204	lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane.   LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709
326424004205	GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421
326424004206	coproporphyrinogen III oxidase; Validated; Region: PRK05628
326424004207	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
326424004208	FeS/SAM binding site; other site
326424004209	heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082
326424004210	Helix-turn-helix domains; Region: HTH; cl00088
326424004211	HrcA protein C terminal domain; Region: HrcA; pfam01628
326424004212	chaperone protein DnaJ; Provisional; Region: PRK14278
326424004213	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
326424004214	HSP70 interaction site [polypeptide binding]; other site
326424004215	Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719
326424004216	Zn binding sites [ion binding]; other site
326424004217	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747
326424004218	dimer interface [polypeptide binding]; other site
326424004219	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1385; cl00611
326424004220	RNA methyltransferase; Region: Methyltrans_RNA; pfam04452
326424004221	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
326424004222	Uncharacterized protein family UPF0054; Region: UPF0054; cl00402
326424004223	Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253
326424004224	Domain of unknown function DUF21; Region: DUF21; pfam01595
326424004225	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
326424004226	Transporter associated domain; Region: CorC_HlyC; cl08393
326424004227	GTPase Era; Reviewed; Region: era; PRK00089
326424004228	E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163
326424004229	G1 box; other site
326424004230	GTP/Mg2+ binding site [chemical binding]; other site
326424004231	Switch I region; other site
326424004232	G2 box; other site
326424004233	Switch II region; other site
326424004234	G3 box; other site
326424004235	G4 box; other site
326424004236	G5 box; other site
326424004237	K homology RNA-binding domain, type I.  KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains that...; Region: KH-I; cl00098
326424004238	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883
326424004239	nudix motif; other site
326424004240	DNA repair protein RecO; Reviewed; Region: recO; PRK00085
326424004241	Recombination protein O N terminal; Region: RecO_N; cl15812
326424004242	Recombination protein O C terminal; Region: RecO_C; pfam02565
326424004243	Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475
326424004244	Putative undecaprenyl diphosphate synthase; Region: Prenyltransf; pfam01255
326424004245	catalytic residue [active]
326424004246	putative FPP diphosphate  binding site; other site
326424004247	putative FPP binding hydrophobic cleft; other site
326424004248	dimer interface [polypeptide binding]; other site
326424004249	putative IPP diphosphate binding site; other site
326424004250	glycyl-tRNA synthetase; Provisional; Region: PRK14908
326424004251	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it attaches...; Region: class_II_aaRS-like_core; cl00268
326424004252	motif 1; other site
326424004253	dimer interface [polypeptide binding]; other site
326424004254	active site
326424004255	motif 2; other site
326424004256	motif 3; other site
326424004257	glycyl-tRNA synthetase; Provisional; Region: PRK14908
326424004258	YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259
326424004259	putative active site [active]
326424004260	transketolase; Reviewed; Region: PRK05899
326424004261	Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012
326424004262	TPP-binding site [chemical binding]; other site
326424004263	dimer interface [polypeptide binding]; other site
326424004264	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
326424004265	PYR/PP interface [polypeptide binding]; other site
326424004266	dimer interface [polypeptide binding]; other site
326424004267	TPP binding site [chemical binding]; other site
326424004268	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
326424004269	Predicted membrane protein [Function unknown]; Region: COG3428
326424004270	Bacterial PH domain; Region: DUF304; cl01348
326424004271	deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional; Region: PRK03007
326424004272	Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286
326424004273	DNA primase; Validated; Region: dnaG; PRK05667
326424004274	CHC2 zinc finger; Region: zf-CHC2; cl15369
326424004275	DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275
326424004276	TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364
326424004277	active site
326424004278	metal binding site [ion binding]; metal-binding site
326424004279	interdomain interaction site; other site
326424004280	DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410
326424004281	DNA primase DnaG DnaB-binding; Region: DnaG_DnaB_bind; cl07879
326424004282	RNA polymerase sigma factor RpoD; Validated; Region: PRK09210
326424004283	Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979
326424004284	Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140
326424004285	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
326424004286	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
326424004287	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
326424004288	DNA binding residues [nucleotide binding]
326424004289	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
326424004290	S-adenosylmethionine binding site [chemical binding]; other site
326424004291	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
326424004292	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
326424004293	OpgC protein; Region: OpgC_C; cl00792
326424004294	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
326424004295	S-adenosylmethionine binding site [chemical binding]; other site
326424004296	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
326424004297	active site
326424004298	Sortase D (SrtD) is a membrane transpeptidase found in gram-positive bacteria that anchors surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the surface protein substrate is cleaved...; Region: Sortase_D_5; cd05830
326424004299	active site
326424004300	catalytic site [active]
326424004301	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
326424004302	metal binding site [ion binding]; metal-binding site
326424004303	active site
326424004304	I-site; other site
326424004305	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
326424004306	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
326424004307	Low molecular weight phosphatase family; Region: LMWPc; cl00105
326424004308	active site
326424004309	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
326424004310	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
326424004311	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
326424004312	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
326424004313	NAD(P) binding site [chemical binding]; other site
326424004314	active site
326424004315	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
326424004316	Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244
326424004317	MatE; Region: MatE; cl10513
326424004318	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4641
326424004319	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
326424004320	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
326424004321	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
326424004322	active site
326424004323	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
326424004324	Heparinase II/III-like protein; Region: Hepar_II_III; cl15421
326424004325	Heparinase II/III-like protein; Region: Hepar_II_III; cl15421
326424004326	UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511
326424004327	putative metal binding site; other site
326424004328	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
326424004329	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
326424004330	NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370
326424004331	NAD(P) binding site [chemical binding]; other site
326424004332	active site
326424004333	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
326424004334	This family is most closely related to the GT1 family of glycosyltransferases. wbuB in E. coli is involved in the biosynthesis of the O26 O-antigen.  It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase; Region: GT1_wbuB_like; cd03794
326424004335	putative glycosyl transferase; Provisional; Region: PRK10307
326424004336	extended (e) SDRs; Region: SDR_e; cd08946
326424004337	substrate binding site [chemical binding]; other site
326424004338	active site
326424004339	The members of this subfamily catalyze the formation of a phosphodiester bond between a membrane-associated undecaprenyl-phosphate (Und-P) molecule and N-acetylhexosamine 1-phosphate, which is usually donated by a soluble UDP-N-acetylhexosamine precursor; Region: GT_WbpL_WbcO_like; cd06854
326424004340	Mg++ binding site [ion binding]; other site
326424004341	putative catalytic motif [active]
326424004342	putative substrate binding site [chemical binding]; other site
326424004343	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
326424004344	2-desacetyl-2-hydroxyethyl bacteriochlorophyllide and other MDR family members; Region: 2-desacetyl-2-hydroxyethyl_bacteriochlorophyllide_; cd08255
326424004345	putative NAD(P) binding site [chemical binding]; other site
326424004346	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
326424004347	GDP-mannose 4,6-dehydratase; Region: PLN02653
326424004348	GDP-mannose 4,6 dehydratase, extended (e) SDRs; Region: GDP_MD_SDR_e; cd05260
326424004349	NADP-binding site; other site
326424004350	homotetramer interface [polypeptide binding]; other site
326424004351	substrate binding site [chemical binding]; other site
326424004352	homodimer interface [polypeptide binding]; other site
326424004353	active site
326424004354	Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase  family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786
326424004355	UDP-N-acetylglucosamine 2-epimerase; Region: Epimerase_2; pfam02350
326424004356	homodimer interface [polypeptide binding]; other site
326424004357	active site
326424004358	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
326424004359	UDP-N-acetyl-D-mannosaminuronate dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: WecC; COG0677
326424004360	UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984
326424004361	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
326424004362	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
326424004363	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
326424004364	O-antigen polysaccharide polymerase Wzy; Region: O-ag_pol_Wzy; pfam14296
326424004365	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
326424004366	S-adenosylmethionine binding site [chemical binding]; other site
326424004367	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
326424004368	Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647
326424004369	active site
326424004370	trimer interface [polypeptide binding]; other site
326424004371	substrate binding site [chemical binding]; other site
326424004372	CoA binding site [chemical binding]; other site
326424004373	aconitate hydratase; Validated; Region: PRK09277
326424004374	Aconitase catalytic domain; Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: Aconitase; cl00285
326424004375	substrate binding site [chemical binding]; other site
326424004376	Aconitase catalytic domain; Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: Aconitase; cl00285
326424004377	ligand binding site [chemical binding]; other site
326424004378	Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580
326424004379	substrate binding site [chemical binding]; other site
326424004380	Evidence 2b : Function of strongly homologous gene; PubMedId : 10361288; Product type e : enzyme
326424004381	ChaP, an enzyme involved in the biosynthesis of the antitumor agent chartreusin (cha); and similar proteins; Region: ChaP_like; cd08351
326424004382	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
326424004383	metal binding site [ion binding]; metal-binding site
326424004384	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
326424004385	Helix-turn-helix domains; Region: HTH; cl00088
326424004386	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
326424004387	F420-dependent oxidoreductase, MSMEG_4879 family; Region: F420_MSMEG_4879; TIGR03564
326424004388	Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase  family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786
326424004389	active site
326424004390	UDP-N-acetylglucosamine 2-epimerase; Region: Epimerase_2; pfam02350
326424004391	homodimer interface [polypeptide binding]; other site
326424004392	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
326424004393	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
326424004394	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_16; cd07263
326424004395	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
326424004396	IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639
326424004397	active site
326424004398	dimerization interface [polypeptide binding]; other site
326424004399	tRNA synthetases class I (I, L, M and V); Region: tRNA-synt_1; pfam00133
326424004400	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
326424004401	active site
326424004402	HIGH motif; other site
326424004403	nucleotide binding site [chemical binding]; other site
326424004404	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
326424004405	active site
326424004406	KMSKS motif; other site
326424004407	Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020
326424004408	tRNA binding surface [nucleotide binding]; other site
326424004409	anticodon binding site; other site
326424004410	valyl-tRNA synthetase; Reviewed; Region: valS; PRK13208
326424004411	Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020
326424004412	Nitrate/nitrite transporter [Inorganic ion transport and metabolism]; Region: NarK; COG2223
326424004413	RNA polymerase sigma factor SigJ; Provisional; Region: PRK09636
326424004414	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
326424004415	Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645
326424004416	trimer interface [polypeptide binding]; other site
326424004417	putative metal binding site [ion binding]; other site
326424004418	Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557
326424004419	trimer interface [polypeptide binding]; other site
326424004420	active site
326424004421	Protein of unknown function (DUF3710); Region: DUF3710; pfam12502
326424004422	RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488
326424004423	generic binding surface II; other site
326424004424	ssDNA binding site; other site
326424004425	Protein of unknown function (DUF3159); Region: DUF3159; pfam11361
326424004426	K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569
326424004427	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
326424004428	Anion permease ArsB/NhaD.  These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life.  A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl15357
326424004429	K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569
326424004430	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
326424004431	Anion permease ArsB/NhaD.  These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life.  A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl15357
326424004432	Amino acid permease; Region: AA_permease_2; pfam13520
326424004433	SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265
326424004434	SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265
326424004435	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl15754
326424004436	1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444
326424004437	Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007
326424004438	TPP-binding site; other site
326424004439	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
326424004440	PYR/PP interface [polypeptide binding]; other site
326424004441	dimer interface [polypeptide binding]; other site
326424004442	TPP binding site [chemical binding]; other site
326424004443	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
326424004444	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
326424004445	Major Facilitator Superfamily; Region: MFS_1; pfam07690
326424004446	putative substrate translocation pore; other site
326424004447	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
326424004448	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
326424004449	Helix-turn-helix domains; Region: HTH; cl00088
326424004450	Protein of unknown function DUF262; Region: DUF262; cl14890
326424004451	HipA N-terminal domain; Region: Couple_hipA; cl11853
326424004452	HipA-like N-terminal domain; Region: HipA_N; pfam07805
326424004453	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
326424004454	multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadJ; PRK11154
326424004455	substrate binding site [chemical binding]; other site
326424004456	oxyanion hole (OAH) forming residues; other site
326424004457	trimer interface [polypeptide binding]; other site
326424004458	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
326424004459	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
326424004460	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
326424004461	acetyl-CoA acetyltransferases; Region: AcCoA-C-Actrans; TIGR01930
326424004462	dimer interface [polypeptide binding]; other site
326424004463	active site
326424004464	Ribonuclease D [Translation, ribosomal structure and biogenesis]; Region: Rnd; COG0349
326424004465	DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142
326424004466	putative active site [active]
326424004467	catalytic site [active]
326424004468	putative substrate binding site [chemical binding]; other site
326424004469	HRDC domain; Region: HRDC; cl02578
326424004470	Protein of unknown function (DUF3000); Region: DUF3000; pfam11452
326424004471	Domain of unknown function (DUF3817); Region: DUF3817; cl14844
326424004472	Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717
326424004473	substrate binding site [chemical binding]; other site
326424004474	active site
326424004475	protoporphyrinogen oxidase; Reviewed; Region: PRK11883
326424004476	Chlorite dismutase; Region: Chlor_dismutase; cl01280
326424004477	exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025
326424004478	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
326424004479	Bacterial sugar transferase; Region: Bac_transf; cl00939
326424004480	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
326424004481	Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically 'activated' sulfate form important for the assimilation of...; Region: APSK; cd02027
326424004482	ligand-binding site [chemical binding]; other site
326424004483	CysQ, a 3'-Phosphoadenosine-5'-phosphosulfate (PAPS) 3'-phosphatase, is a bacterial member of the inositol monophosphatase family. It has been proposed that CysQ helps control intracellular levels of PAPS, which is an intermediate in cysteine...; Region: CysQ; cd01638
326424004484	active site
326424004485	sulfate adenylyltransferase, small subunit; Region: CysD; TIGR02039
326424004486	This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713
326424004487	Active Sites [active]
326424004488	GTPases - Sulfate adenylate transferase subunit 1 [Inorganic ion transport and metabolism]; Region: CysN; COG2895
326424004489	CysN, together with protein CysD, forms the ATP sulfurylase (ATPS) complex; Region: CysN_ATPS; cd04166
326424004490	CysD dimerization site [polypeptide binding]; other site
326424004491	G1 box; other site
326424004492	putative GEF interaction site [polypeptide binding]; other site
326424004493	GTP/Mg2+ binding site [chemical binding]; other site
326424004494	Switch I region; other site
326424004495	G2 box; other site
326424004496	G3 box; other site
326424004497	Switch II region; other site
326424004498	G4 box; other site
326424004499	G5 box; other site
326424004500	CysN_NodQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NodQ_II; cd03695
326424004501	TCysN_NoDQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NoDQ_III; cd04095
326424004502	Adenylation domain of Mycobacterium tuberculosis LigC-like ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_LigC; cd07905
326424004503	active site
326424004504	DNA binding site [nucleotide binding]
326424004505	The Oligonucleotide/oligosaccharide binding (OB)-fold domain of ATP-dependent DNA ligase LigC is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_LigC; cd07970
326424004506	DNA binding site [nucleotide binding]
326424004507	Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cl00161
326424004508	AFG1-like ATPase; Region: AFG1_ATPase; pfam03969
326424004509	N-terminal Early set domain associated with the catalytic domain of Maltooligosyl trehalose trehalohydrolase (also called Glycosyltrehalose trehalohydrolase) and similar proteins; Region: E_set_MTHase_like_N; cd02853
326424004510	malto-oligosyltrehalose trehalohydrolase; Region: trehalose_TreZ; TIGR02402
326424004511	Alpha amylase catalytic domain found in Glycosyltrehalose trehalohydrolase (also called Maltooligosyl trehalose Trehalohydrolase); Region: AmyAc_GTHase; cd11325
326424004512	catalytic site [active]
326424004513	active site
326424004514	Domain of unknown function (DUF3459); Region: DUF3459; pfam11941
326424004515	maltooligosyl trehalose synthase; Provisional; Region: PRK14511
326424004516	Alpha amylase catalytic domain found in maltooligosyl trehalose synthase (MTSase); Region: AmyAc_MTSase; cd11336
326424004517	active site
326424004518	catalytic site [active]
326424004519	glycogen debranching enzyme GlgX; Region: glgX_debranch; TIGR02100
326424004520	N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856
326424004521	Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326
326424004522	active site
326424004523	catalytic site [active]
326424004524	NfeD-like C-terminal, partner-binding; Region: NfeD; cl00686
326424004525	Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403
326424004526	Protein of unknown function (DUF3145); Region: DUF3145; pfam11343
326424004527	Domain of unknown function (DUF4193); Region: DUF4193; pfam13834
326424004528	Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cl00220
326424004529	Isochorismatase family; Region: Isochorismatase; pfam00857
326424004530	catalytic triad [active]
326424004531	conserved cis-peptide bond; other site
326424004532	Protein of unknown function (DUF3097); Region: DUF3097; pfam11296
326424004533	N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860
326424004534	N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696
326424004535	active site
326424004536	metal binding site [ion binding]; metal-binding site
326424004537	aminodeoxychorismate synthase, component I, clade 2; Region: PabB-clade2; TIGR01824
326424004538	chorismate binding enzyme; Region: Chorismate_bind; cl10555
326424004539	Streptomyces sporulation and cell division protein, SsgA; Region: SsgA; pfam04686
326424004540	FHIT (fragile histidine family): FHIT proteins, related to the HIT family carry a motif HxHxH/Qxx (x, is a hydrophobic amino acid), On the basis of sequence, substrate specificity, structure, evolution and mechanism, HIT proteins are classified into...; Region: FHIT; cd01275
326424004541	nucleotide binding site/active site [active]
326424004542	HIT family signature motif; other site
326424004543	catalytic residue [active]
326424004544	elongation factor G; Reviewed; Region: PRK12740
326424004545	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
326424004546	G1 box; other site
326424004547	GTP/Mg2+ binding site [chemical binding]; other site
326424004548	G2 box; other site
326424004549	Switch I region; other site
326424004550	G3 box; other site
326424004551	Switch II region; other site
326424004552	G4 box; other site
326424004553	EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088
326424004554	EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434
326424004555	EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G.  Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713
326424004556	CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453
326424004557	Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279
326424004558	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984
326424004559	putative acyl-acceptor binding pocket; other site
326424004560	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
326424004561	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
326424004562	pyridoxal 5'-phosphate synthase, synthase subunit Pdx1; Region: TIGR00343
326424004563	PdxS is a subunit of the pyridoxal 5'-phosphate (PLP) synthase, an important enzyme in deoxyxylulose 5-phosphate (DXP)-independent pathway for de novo biosynthesis of PLP,  present in some eubacteria, in archaea, fungi, plants, plasmodia, and some...; Region: pdxS; cd04727
326424004564	active site
326424004565	multimer interface [polypeptide binding]; other site
326424004566	Glutamine Amidotransferase (GATase_I) involved in pyridoxine biosynthesis; Region: GATase1_PB; cd01749
326424004567	imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13143
326424004568	predicted active site [active]
326424004569	catalytic triad [active]
326424004570	Transcriptional regulator; Region: Transcrip_reg; cl00361
326424004571	Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination.  HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD includes...; Region: RuvC_resolvase; cd00529
326424004572	active site
326424004573	putative DNA-binding cleft [nucleotide binding]; other site
326424004574	dimer interface [polypeptide binding]; other site
326424004575	Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116
326424004576	Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080
326424004577	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
326424004578	Walker A motif; other site
326424004579	ATP binding site [chemical binding]; other site
326424004580	Walker B motif; other site
326424004581	arginine finger; other site
326424004582	Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491
326424004583	Preprotein translocase subunit; Region: YajC; cl00806
326424004584	bifunctional preprotein translocase subunit SecD/SecF; Reviewed; Region: PRK13024
326424004585	preprotein translocase subunit SecD; Reviewed; Region: secD; PRK05812
326424004586	Protein export membrane protein; Region: SecD_SecF; cl14618
326424004587	preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022
326424004588	Protein export membrane protein; Region: SecD_SecF; cl14618
326424004589	Adenine/guanine phosphoribosyltransferases and related PRPP-binding proteins [Nucleotide transport and metabolism]; Region: Apt; COG0503
326424004590	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
326424004591	(p)ppGpp synthetase, RelA/SpoT family; Region: spoT_relA; TIGR00691
326424004592	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076
326424004593	Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399
326424004594	synthetase active site [active]
326424004595	NTP binding site [chemical binding]; other site
326424004596	metal binding site [ion binding]; metal-binding site
326424004597	TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668
326424004598	ACT  domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876
326424004599	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076
326424004600	Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399
326424004601	synthetase active site [active]
326424004602	NTP binding site [chemical binding]; other site
326424004603	metal binding site [ion binding]; metal-binding site
326424004604	TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668
326424004605	(p)ppGpp synthetase I/GTP pyrophosphokinase; Provisional; Region: relA; PRK10872
326424004606	ACT  domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876
326424004607	CutA1 divalent ion tolerance protein; Region: CutA1; cl00584
326424004608	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761
326424004609	DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061
326424004610	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
326424004611	ATP binding site [chemical binding]; other site
326424004612	putative Mg++ binding site [ion binding]; other site
326424004613	cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317
326424004614	active site
326424004615	seryl-tRNA synthetase; Provisional; Region: PRK05431
326424004616	Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403
326424004617	Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme bound...; Region: SerRS_core; cd00770
326424004618	dimer interface [polypeptide binding]; other site
326424004619	active site
326424004620	motif 1; other site
326424004621	motif 2; other site
326424004622	motif 3; other site
326424004623	Trans-Isoprenyl Diphosphate Synthases, head-to-head; Region: Trans_IPPS_HH; cd00683
326424004624	active site lid residues [active]
326424004625	substrate binding pocket [chemical binding]; other site
326424004626	catalytic residues [active]
326424004627	substrate-Mg2+ binding site; other site
326424004628	aspartate-rich region 1; other site
326424004629	aspartate-rich region 2; other site
326424004630	Domain of unknown function (DUF222); Region: DUF222; pfam02720
326424004631	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057
326424004632	metal ion-dependent adhesion site (MIDAS); other site
326424004633	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057
326424004634	MoxR-like ATPases [General function prediction only]; Region: COG0714
326424004635	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
326424004636	Walker A motif; other site
326424004637	ATP binding site [chemical binding]; other site
326424004638	Walker B motif; other site
326424004639	arginine finger; other site
326424004640	phytoene desaturase; Region: crtI_fam; TIGR02734
326424004641	Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685
326424004642	substrate binding pocket [chemical binding]; other site
326424004643	chain length determination region; other site
326424004644	substrate-Mg2+ binding site; other site
326424004645	catalytic residues [active]
326424004646	aspartate-rich region 1; other site
326424004647	active site lid residues [active]
326424004648	aspartate-rich region 2; other site
326424004649	Domain of unknown function (DUF4098); Region: DUF4098; pfam13345
326424004650	Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537
326424004651	Methylenetetrahydrofolate reductase; Region: MTHFR; pfam02219
326424004652	FAD binding site [chemical binding]; other site
326424004653	CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453
326424004654	Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199
326424004655	metal coordination site [ion binding]; other site
326424004656	phytoene desaturase; Region: crtI_fam; TIGR02734
326424004657	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
326424004658	active site
326424004659	Protein of unknown function (DUF422); Region: DUF422; cl00991
326424004660	N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357
326424004661	Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052
326424004662	FAD dependent oxidoreductase; Region: DAO; pfam01266
326424004663	Helix-turn-helix domains; Region: HTH; cl00088
326424004664	DNA binding site [nucleotide binding]
326424004665	Bacterial transcriptional activator domain; Region: BTAD; pfam03704
326424004666	NB-ARC domain; Region: NB-ARC; pfam00931
326424004667	Tetratricopeptide repeat; Region: TPR_12; pfam13424
326424004668	Tetratricopeptide repeat; Region: TPR_12; pfam13424
326424004669	DNA Polymerase Y-family; Region: PolY_like; cd03468
326424004670	DNA binding site [nucleotide binding]
326424004671	error-prone DNA polymerase; Validated; Region: dnaE2; PRK05672
326424004672	Bacterial DNA polymerase III alpha subunit; Region: DNA_pol3_alpha; pfam07733
326424004673	DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485
326424004674	generic binding surface II; other site
326424004675	generic binding surface I; other site
326424004676	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
326424004677	S-adenosylmethionine binding site [chemical binding]; other site
326424004678	DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586
326424004679	DNA binding site [nucleotide binding]
326424004680	Transglutaminase-like superfamily; Region: Transglut_core; cl10469
326424004681	Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721
326424004682	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057
326424004683	MoxR-like ATPases [General function prediction only]; Region: COG0714
326424004684	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
326424004685	Walker A motif; other site
326424004686	ATP binding site [chemical binding]; other site
326424004687	Walker B motif; other site
326424004688	arginine finger; other site
326424004689	cell division protein MraZ; Reviewed; Region: PRK00326
326424004690	MraZ protein; Region: MraZ; pfam02381
326424004691	MraZ protein; Region: MraZ; pfam02381
326424004692	Predicted S-adenosylmethionine-dependent methyltransferase involved in cell envelope biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG0275
326424004693	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
326424004694	Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768
326424004695	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
326424004696	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009
326424004697	UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139
326424004698	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
326424004699	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
326424004700	UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase; Region: murF; TIGR01143
326424004701	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
326424004702	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
326424004703	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
326424004704	phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108
326424004705	Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852
326424004706	Mg++ binding site [ion binding]; other site
326424004707	putative catalytic motif [active]
326424004708	putative substrate binding site [chemical binding]; other site
326424004709	UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK01438
326424004710	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
326424004711	Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511
326424004712	undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726
326424004713	MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785
326424004714	active site
326424004715	homodimer interface [polypeptide binding]; other site
326424004716	Domain of unknown function (DUF385); Region: DUF385; cl04387
326424004717	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
326424004718	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
326424004719	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
326424004720	FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes.  FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201
326424004721	nucleotide binding site [chemical binding]; other site
326424004722	SulA interaction site; other site
326424004723	Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496
326424004724	Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; cl00650
326424004725	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261
326424004726	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
326424004727	catalytic residue [active]
326424004728	Protein of unknown function (DUF552); Region: DUF552; cl00775
326424004729	DivIVA domain; Region: DivI1A_domain; TIGR03544
326424004730	isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK06039
326424004731	catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818
326424004732	HIGH motif; other site
326424004733	catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818
326424004734	active site
326424004735	KMSKS motif; other site
326424004736	Anticodon-binding domain of archaeal, bacterial, and eukaryotic cytoplasmic isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_ABEc; cd07961
326424004737	tRNA binding surface [nucleotide binding]; other site
326424004738	anticodon binding site; other site
326424004739	Signal peptidase (SPase) II; Region: Peptidase_A8; cl00458
326424004740	pseudouridine synthase, RluA family; Region: rluA_subfam; TIGR00005
326424004741	PseudoU_synth_RsuA/RluD: Pseudouridine synthase, RsuA/RluD family. This group is comprised of eukaryotic, bacterial and archeal proteins similar to eight site specific Escherichia coli pseudouridine synthases: RsuA, RluA, RluB, RluC, RluD, RluE, RluF and...; Region: PseudoU_synth_RluCD_like; cd02869
326424004742	active site
326424004743	The ABCA subfamily mediates the transport of a variety of lipid compounds.  Mutations of members of ABCA subfamily are associated with human genetic diseases, such as, familial high-density lipoprotein (HDL) deficiency, neonatal surfactant deficiency; Region: ABC_subfamily_A; cd03263
326424004744	daunorubicin resistance ABC transporter ATP-binding subunit; Region: drrA; TIGR01188
326424004745	Walker A/P-loop; other site
326424004746	ATP binding site [chemical binding]; other site
326424004747	Q-loop/lid; other site
326424004748	ABC transporter signature motif; other site
326424004749	Walker B; other site
326424004750	D-loop; other site
326424004751	H-loop/switch region; other site
326424004752	ATP-dependent protease La (LON) domain; Region: LON; pfam02190
326424004753	Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which...; Region: ZnMc; cl00064
326424004754	active site
326424004755	Uncharacterized conserved protein [Function unknown]; Region: COG0327
326424004756	NIF3 (NGG1p interacting factor 3); Region: NIF3; cl15371
326424004757	Zn-ribbon protein, possibly nucleic acid-binding [General function prediction only]; Region: COG1579
326424004758	Putative zinc ribbon domain; Region: DUF164; pfam02591
326424004759	bifunctional RNase H/acid phosphatase; Provisional; Region: PRK07238
326424004760	RNAse HI family that includes Archaeal RNase HI; Region: RNase_HI_archaeal_like; cd09279
326424004761	RNA/DNA hybrid binding site [nucleotide binding]; other site
326424004762	active site
326424004763	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
326424004764	catalytic core [active]
326424004765	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
326424004766	Predicted membrane protein (DUF2306); Region: DUF2306; cl02232
326424004767	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075
326424004768	Helix-turn-helix domains; Region: HTH; cl00088
326424004769	DNA binding residues [nucleotide binding]
326424004770	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
326424004771	Protein kinase domain; Region: Pkinase; pfam00069
326424004772	active site
326424004773	ATP binding site [chemical binding]; other site
326424004774	substrate binding site [chemical binding]; other site
326424004775	activation loop (A-loop); other site
326424004776	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
326424004777	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
326424004778	active site
326424004779	ATP binding site [chemical binding]; other site
326424004780	substrate binding site [chemical binding]; other site
326424004781	activation loop (A-loop); other site
326424004782	Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446
326424004783	mycothiol-dependent formaldehyde dehydrogenase; Region: mycoS_dep_FDH; TIGR03451
326424004784	Class III alcohol dehydrogenase; Region: Zn_ADH_class_III; cd08279
326424004785	NAD binding site [chemical binding]; other site
326424004786	catalytic Zn binding site [ion binding]; other site
326424004787	substrate binding site [chemical binding]; other site
326424004788	structural Zn binding site [ion binding]; other site
326424004789	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
326424004790	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
326424004791	P-loop; other site
326424004792	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
326424004793	Magnesium ion binding site [ion binding]; other site
326424004794	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
326424004795	Magnesium ion binding site [ion binding]; other site
326424004796	Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cd05709
326424004797	active site
326424004798	putative substrate binding region [chemical binding]; other site
326424004799	ScpA/B protein; Region: ScpA_ScpB; cl00598
326424004800	Putative transcriptional regulators (Ypuh-like); Region: DUF387; cl00612
326424004801	16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187
326424004802	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
326424004803	RNA binding surface [nucleotide binding]; other site
326424004804	Pseudouridine synthases  are responsible for the synthesis of pseudouridine from uracil in ribosomal RNA. The RsuA subfamily includes Pseudouridine Synthase similar to Ribosomal small subunit pseudouridine 516 synthase. Most of the proteins in this...; Region: PseudoU_synth_RsuA_like; cd02870
326424004805	active site
326424004806	prephenate dehydrogenase; Validated; Region: PRK06545
326424004807	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
326424004808	ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141
326424004809	cytidylate kinase; Provisional; Region: cmk; PRK00023
326424004810	Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020
326424004811	CMP-binding site; other site
326424004812	The sites determining sugar specificity; other site
326424004813	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
326424004814	putative acyl-acceptor binding pocket; other site
326424004815	GTP-binding protein Der; Reviewed; Region: PRK03003
326424004816	EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894
326424004817	G1 box; other site
326424004818	GTP/Mg2+ binding site [chemical binding]; other site
326424004819	Switch I region; other site
326424004820	G2 box; other site
326424004821	Switch II region; other site
326424004822	G3 box; other site
326424004823	G4 box; other site
326424004824	G5 box; other site
326424004825	EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895
326424004826	G1 box; other site
326424004827	GTP/Mg2+ binding site [chemical binding]; other site
326424004828	Switch I region; other site
326424004829	G2 box; other site
326424004830	G3 box; other site
326424004831	Switch II region; other site
326424004832	G4 box; other site
326424004833	G5 box; other site
326424004834	atypical (a) SDRs, subgroup 7; Region: SDR_a7; cd05262
326424004835	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
326424004836	putative NAD(P) binding site [chemical binding]; other site
326424004837	Helix-turn-helix domains; Region: HTH; cl00088
326424004838	alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859
326424004839	Sortase E (SrtE) is a membrane transpeptidase found in gram-positive bacteria that cleaves surface proteins at a cell sorting motif and catalyzes a transpeptidation reaction in which the surface protein substrate is covalently linked to peptidoglycan for...; Region: Sortase_E; cd05829
326424004840	active site
326424004841	putative catalytic site [active]
326424004842	Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383
326424004843	NlpC/P60 family; Region: NLPC_P60; cl11438
326424004844	CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453
326424004845	Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208
326424004846	NTP_transferases catalyze the transfer of nucleotides onto phosphosugars; Region: NTP_transferase; cd04181
326424004847	active site
326424004848	Substrate binding site; other site
326424004849	Mg++ binding site; other site
326424004850	Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160
326424004851	putative trimer interface [polypeptide binding]; other site
326424004852	putative CoA binding site [chemical binding]; other site
326424004853	phosphoglucosamine mutase; Region: Arch_GlmM; TIGR03990
326424004854	GTP-mannose-1-phosphate guanyltransferase (MPG1 transferase), also known as GDP-mannose pyrophosphorylase, is a bifunctional enzyme with both phosphomannose isomerase (PMI) activity and GDP-mannose phosphorylase (GMP) activity.  The protein contains an...; Region: MPG1_transferase; cd05805
326424004855	Bacterial protein of unknown function (DUF881); Region: DUF881; pfam05949
326424004856	Protein of unknown function (DUF1290); Region: DUF1290; cl01587
326424004857	Bacterial protein of unknown function (DUF881); Region: DUF881; pfam05949
326424004858	Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848
326424004859	lipoyl attachment site [posttranslational modification]; other site
326424004860	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
326424004861	phosphopeptide binding site; other site
326424004862	Helix-Turn-Helix DNA binding domain of MerR-like transcription regulators; Region: HTH_MerR-like; cd00592
326424004863	DNA binding residues [nucleotide binding]
326424004864	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
326424004865	Bifunctional nuclease; Region: DNase-RNase; cl00553
326424004866	Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600
326424004867	DNA binding residues [nucleotide binding]
326424004868	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
326424004869	daunorubicin resistance ABC transporter ATP-binding subunit; Region: drrA; TIGR01188
326424004870	Walker A/P-loop; other site
326424004871	ATP binding site [chemical binding]; other site
326424004872	Q-loop/lid; other site
326424004873	ABC transporter signature motif; other site
326424004874	Walker B; other site
326424004875	D-loop; other site
326424004876	H-loop/switch region; other site
326424004877	ABC-2 type transporter; Region: ABC2_membrane; cl11417
326424004878	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
326424004879	Trehalose-6-Phosphate Synthase (TPS) is a glycosyltransferase that catalyses the synthesis of alpha,alpha-1,1-trehalose-6-phosphate from glucose-6-phosphate using a UDP-glucose donor. It is a key enzyme in the trehalose synthesis pathway. Trehalose is a...; Region: GT1_TPS; cd03788
326424004880	active site
326424004881	homotetramer interface [polypeptide binding]; other site
326424004882	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
326424004883	catalytic core [active]
326424004884	Transcription factor WhiB; Region: Whib; pfam02467
326424004885	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125
326424004886	active site residue [active]
326424004887	Cysteine dioxygenase type I; Region: CDO_I; cl15835
326424004888	GAF domain; Region: GAF_2; pfam13185
326424004889	GAF domain; Region: GAF; cl15785
326424004890	Histidine kinase; Region: HisKA_3; pfam07730
326424004891	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075
326424004892	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
326424004893	active site
326424004894	phosphorylation site [posttranslational modification]
326424004895	intermolecular recognition site; other site
326424004896	dimerization interface [polypeptide binding]; other site
326424004897	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
326424004898	DNA binding residues [nucleotide binding]
326424004899	dimerization interface [polypeptide binding]; other site
326424004900	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
326424004901	Domain of unknown function (DUF222); Region: DUF222; pfam02720
326424004902	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
326424004903	active site
326424004904	Rhomboid family; Region: Rhomboid; cl11446
326424004905	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
326424004906	adenosylmethionine-8-amino-7-oxononanoate transaminase; Region: bioA; TIGR00508
326424004907	inhibitor-cofactor binding pocket; inhibition site
326424004908	pyridoxal 5'-phosphate binding site [chemical binding]; other site
326424004909	catalytic residue [active]
326424004910	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
326424004911	metal binding site [ion binding]; metal-binding site
326424004912	active site
326424004913	I-site; other site
326424004914	Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763
326424004915	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
326424004916	NAD(P) binding pocket [chemical binding]; other site
326424004917	tetracycline repressor protein TetR; Provisional; Region: PRK13756
326424004918	Helix-turn-helix domains; Region: HTH; cl00088
326424004919	Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909
326424004920	Predicted acetyltransferase [General function prediction only]; Region: COG3153
326424004921	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
326424004922	Coenzyme A binding pocket [chemical binding]; other site
326424004923	Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381
326424004924	Predicted transcriptional regulator [Transcription]; Region: COG2378
326424004925	Helix-turn-helix domains; Region: HTH; cl00088
326424004926	WYL domain; Region: WYL; cl14852
326424004927	Protein of unknown function (DUF456); Region: DUF456; cl01069
326424004928	Amidinotransferase; Region: Amidinotransf; cl12043
326424004929	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
326424004930	Helix-turn-helix domains; Region: HTH; cl00088
326424004931	Alpha amylase catalytic domain found in bacterial cyclomaltodextrinases and related proteins; Region: AmyAc_bac_CMD_like; cd11354
326424004932	active site
326424004933	catalytic site [active]
326424004934	formyltetrahydrofolate deformylase; Reviewed; Region: purU; PRK06027
326424004935	N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875
326424004936	Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648
326424004937	putative active site [active]
326424004938	putative substrate binding site [chemical binding]; other site
326424004939	putative cosubstrate binding site; other site
326424004940	catalytic site [active]
326424004941	Phosphopantetheinyl transferase component of siderophore synthetase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntD; COG2977
326424004942	4'-phosphopantetheinyl transferase superfamily; Region: ACPS; cl00500
326424004943	Predicted phosphohydrolases [General function prediction only]; Region: Icc; COG1409
326424004944	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
326424004945	active site
326424004946	metal binding site [ion binding]; metal-binding site
326424004947	Protein of unknown function (DUF1232); Region: DUF1232; cl01318
326424004948	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
326424004949	Uncharacterized proteins involved in stress response, homologs of TerZ and putative cAMP-binding protein CABP1 [Signal transduction mechanisms]; Region: TerZ; COG2310
326424004950	Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974
326424004951	putative metal binding site [ion binding]; other site
326424004952	TIR domain; Region: TIR_2; cl15770
326424004953	TIR domain; Region: TIR_2; cl15770
326424004954	TIR domain; Region: TIR_2; cl15770
326424004955	Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455
326424004956	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
326424004957	P-loop; other site
326424004958	Magnesium ion binding site [ion binding]; other site
326424004959	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
326424004960	Tetratricopeptide repeat; Region: TPR_12; pfam13424
326424004961	Tetratricopeptide repeat; Region: TPR_12; pfam13424
326424004962	Tetratricopeptide repeat; Region: TPR_12; pfam13424
326424004963	Tetratricopeptide repeat; Region: TPR_12; pfam13424
326424004964	3-(3-hydroxyphenyl)propionate hydroxylase; Validated; Region: mhpA; PRK06183
326424004965	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
326424004966	Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109
326424004967	DNA binding residues [nucleotide binding]
326424004968	putative dimer interface [polypeptide binding]; other site
326424004969	Predicted oxidoreductases (related to aryl-alcohol dehydrogenases) [Energy production and conversion]; Region: Tas; COG0667
326424004970	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
326424004971	active site
326424004972	catalytic tetrad [active]
326424004973	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
326424004974	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
326424004975	active site
326424004976	phosphorylation site [posttranslational modification]
326424004977	intermolecular recognition site; other site
326424004978	dimerization interface [polypeptide binding]; other site
326424004979	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
326424004980	DNA binding site [nucleotide binding]
326424004981	cobaltochelatase subunit CobN; Reviewed; Region: cobN; PRK05989
326424004982	CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150
326424004983	CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150
326424004984	precorrin-3B synthase; Region: CobG; TIGR02435
326424004985	Sulfite reductase, beta subunit (hemoprotein) [Inorganic ion transport and metabolism]; Region: CysI; COG0155
326424004986	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
326424004987	Precorrin isomerase [Coenzyme metabolism]; Region: CobH; cl00913
326424004988	Precorrin-8X methylmutase; Region: CbiC; pfam02570
326424004989	Precorrin-3B methylase [Coenzyme metabolism]; Region: CobJ; cl00304
326424004990	Tetrapyrrole (Corrin/Porphyrin) Methylases; Region: TP_methylase; pfam00590
326424004991	Precorrin-3B methylase [Coenzyme metabolism]; Region: CobJ; cl00304
326424004992	Precorrin-6x reductase CbiJ/CobK; Region: CbiJ; cl00922
326424004993	Precorrin-3B methylase [Coenzyme metabolism]; Region: CobJ; cl00304
326424004994	Tetrapyrrole (Corrin/Porphyrin) Methylases; Region: TP_methylase; pfam00590
326424004995	Protein of unknown function (DUF3710); Region: DUF3710; pfam12502
326424004996	Domain of unknown function (DUF1768); Region: DUF1768; cl01271
326424004997	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
326424004998	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
326424004999	Walker A motif; other site
326424005000	ATP binding site [chemical binding]; other site
326424005001	AAA family ATPase, CDC48 subfamily; Region: CDC48; TIGR01243
326424005002	3-methylcrotonyl-CoA carboxylase, beta chain; Region: PLN02820
326424005003	Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl15772
326424005004	acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591
326424005005	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
326424005006	ATP-grasp domain; Region: ATP-grasp_4; cl03087
326424005007	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; cl08365
326424005008	Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770
326424005009	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
326424005010	carboxyltransferase (CT) interaction site; other site
326424005011	biotinylation site [posttranslational modification]; other site
326424005012	EBNA-3B; Provisional; Region: PHA03378
326424005013	TIR domain; Region: TIR_2; cl15770
326424005014	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761
326424005015	Tetratricopeptide repeat; Region: TPR_10; pfam13374
326424005016	Tetratricopeptide repeat; Region: TPR_12; pfam13424
326424005017	Tetratricopeptide repeat; Region: TPR_12; pfam13424
326424005018	Protein of unknown function (DUF3616); Region: DUF3616; pfam12275
326424005019	ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192
326424005020	substrate binding site [chemical binding]; other site
326424005021	ATP binding site [chemical binding]; other site
326424005022	Cupin domain; Region: Cupin_2; cl09118
326424005023	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
326424005024	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
326424005025	Protein of unknown function (DUF2000); Region: DUF2000; cl02074
326424005026	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447
326424005027	nudix motif; other site
326424005028	K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569
326424005029	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
326424005030	Ion channel; Region: Ion_trans_2; cl11596
326424005031	K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569
326424005032	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
326424005033	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
326424005034	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
326424005035	non-specific DNA binding site [nucleotide binding]; other site
326424005036	salt bridge; other site
326424005037	sequence-specific DNA binding site [nucleotide binding]; other site
326424005038	Predicted transcriptional regulator [General function prediction only]; Region: COG3800
326424005039	Domain of unknown function (DUF955); Region: DUF955; cl01076
326424005040	Predicted transcriptional regulator (DUF2083); Region: DUF2083; pfam09856
326424005041	PEP phosphonomutase and related enzymes [Carbohydrate transport and metabolism]; Region: PrpB; COG2513
326424005042	Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377
326424005043	tetramer interface [polypeptide binding]; other site
326424005044	active site
326424005045	Mg2+/Mn2+ binding site [ion binding]; other site
326424005046	malate synthase A; Region: malate_syn_A; TIGR01344
326424005047	Pyruvate kinase (PK):  Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl09155
326424005048	active site
326424005049	NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961
326424005050	AMP-binding enzyme; Region: AMP-binding; cl15778
326424005051	mycofactocin system transcriptional regulator; Region: mycofact_TetR; TIGR03968
326424005052	Helix-turn-helix domains; Region: HTH; cl00088
326424005053	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
326424005054	methyl viologen resistance protein SmvA; Provisional; Region: PRK14995
326424005055	putative substrate translocation pore; other site
326424005056	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
326424005057	acetoin dehydrogenase E2 subunit dihydrolipoyllysine-residue acetyltransferase; Provisional; Region: PRK14875
326424005058	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
326424005059	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
326424005060	active site
326424005061	Predicted acyl esterases [General function prediction only]; Region: COG2936
326424005062	X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; cl08482
326424005063	topology modulation protein; Reviewed; Region: PRK08118
326424005064	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
326424005065	active site
326424005066	Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588
326424005067	dimer interface [polypeptide binding]; other site
326424005068	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
326424005069	drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711
326424005070	putative substrate translocation pore; other site
326424005071	Glutamate synthase domain 2 [Amino acid transport and metabolism]; Region: GltB; COG0069
326424005072	Glutamate synthase (GltS) FMN-binding domain.  GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808
326424005073	active site
326424005074	FMN binding site [chemical binding]; other site
326424005075	substrate binding site [chemical binding]; other site
326424005076	3Fe-4S cluster binding site [ion binding]; other site
326424005077	similar to hypothetical protein; Evidence 5 : No homology to any previously reported sequences
326424005078	Condensation domain; Region: Condensation; pfam00668
326424005079	Citrate synthase; Region: Citrate_synt; pfam00285
326424005080	Citrate synthase (CS), citryl-CoA lyase (CCL), the C-terminal portion of the single-subunit type ATP-citrate lyase (ACL) and the C-terminal portion of the large subunit of the two-subunit type ACL. CS catalyzes the condensation of acetyl coenzyme A; Region: CS_ACL-C_CCL; cl00416
326424005081	oxalacetate binding site [chemical binding]; other site
326424005082	citrylCoA binding site [chemical binding]; other site
326424005083	coenzyme A binding site [chemical binding]; other site
326424005084	catalytic triad [active]
326424005085	Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600
326424005086	DNA binding residues [nucleotide binding]
326424005087	Citrate synthase (CS), citryl-CoA lyase (CCL), the C-terminal portion of the single-subunit type ATP-citrate lyase (ACL) and the C-terminal portion of the large subunit of the two-subunit type ACL. CS catalyzes the condensation of acetyl coenzyme A; Region: CS_ACL-C_CCL; cl00416
326424005088	Citrate synthase; Region: Citrate_synt; pfam00285
326424005089	Citrate synthase (CS), citryl-CoA lyase (CCL), the C-terminal portion of the single-subunit type ATP-citrate lyase (ACL) and the C-terminal portion of the large subunit of the two-subunit type ACL. CS catalyzes the condensation of acetyl coenzyme A; Region: CS_ACL-C_CCL; cl00416
326424005090	oxalacetate binding site [chemical binding]; other site
326424005091	citrylCoA binding site [chemical binding]; other site
326424005092	coenzyme A binding site [chemical binding]; other site
326424005093	catalytic triad [active]
326424005094	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
326424005095	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
326424005096	substrate binding pocket [chemical binding]; other site
326424005097	membrane-bound complex binding site; other site
326424005098	hinge residues; other site
326424005099	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
326424005100	dimer interface [polypeptide binding]; other site
326424005101	conserved gate region; other site
326424005102	ABC-ATPase subunit interface; other site
326424005103	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
326424005104	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
326424005105	Walker A/P-loop; other site
326424005106	ATP binding site [chemical binding]; other site
326424005107	Q-loop/lid; other site
326424005108	ABC transporter signature motif; other site
326424005109	Walker B; other site
326424005110	D-loop; other site
326424005111	H-loop/switch region; other site
326424005112	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761
326424005113	drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711
326424005114	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
326424005115	hydrogenase nickel incorporation protein; Provisional; Region: hypA; cl00418
326424005116	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
326424005117	Putative [NiFe] hydrogenase-specific C-terminal protease. Sequence comparison shows similarity to hydrogenase specific C-terminal endopeptidases, also called Hydrogen Maturation Proteases (H2MP). Maturation of [FeNi] hydrogenases includes formation of...; Region: H2MP_like-1; cd06068
326424005118	nickel binding site [ion binding]; other site
326424005119	NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; cl15792
326424005120	Nickel-dependent hydrogenase; Region: NiFeSe_Hases; cl00417
326424005121	NifU-like domain; Region: NifU; cl00484
326424005122	Hydrogenase maturation factor [Posttranslational modification, protein turnover, chaperones]; Region: HypF; COG0068
326424005123	Acylphosphatase; Region: Acylphosphatase; cl00551
326424005124	HypF finger; Region: zf-HYPF; pfam07503
326424005125	HypF finger; Region: zf-HYPF; pfam07503
326424005126	Telomere recombination; Region: Sua5_yciO_yrdC; cl00305
326424005127	HupF/HypC family; Region: HupF_HypC; cl00394
326424005128	Hydrogenase formation hypA family; Region: HypD; cl12072
326424005129	hydrogenase expression/formation protein HypD; Region: hypD; TIGR00075
326424005130	HypE (Hydrogenase expression/formation protein). HypE is involved in Ni-Fe hydrogenase biosynthesis.  HypE dehydrates its own carbamoyl moiety in an ATP-dependent process to yield the enzyme thiocyanate. The N-terminal domain of HypE is related to the...; Region: HypE; cd02197
326424005131	dimerization interface [polypeptide binding]; other site
326424005132	hydrogenase expression/formation protein HypE; Region: hypE; TIGR02124
326424005133	ATP binding site [chemical binding]; other site
326424005134	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box protein; Region: CSP_CDS; cd04458
326424005135	DNA-binding site [nucleotide binding]; DNA binding site
326424005136	RNA-binding motif; other site
326424005137	Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384
326424005138	Diaminopimelate epimerase; Region: DAP_epimerase; cl14668
326424005139	Diaminopimelate epimerase; Region: DAP_epimerase; cl14668
326424005140	Domain of unknown function (DUF1707); Region: DUF1707; pfam08044
326424005141	Protein of unknown function (DUF4237); Region: DUF4237; pfam14021
326424005142	Peptidase M14-like domain; uncharacterized subfamily; Region: M14-like_6; cd06233
326424005143	putative active site [active]
326424005144	Zn binding site [ion binding]; other site
326424005145	Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452
326424005146	substrate binding site [chemical binding]; other site
326424005147	nucleotide binding site [chemical binding]; other site
326424005148	aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874
326424005149	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
326424005150	Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; cl15856
326424005151	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
326424005152	NAD(P) binding site [chemical binding]; other site
326424005153	active site
326424005154	proposed F420-0 ABC transporter, ATP-binding protein; Region: F420-0_ABC_ATP; TIGR03873
326424005155	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
326424005156	ABC-ATPase subunit  interface; other site
326424005157	dimer interface [polypeptide binding]; other site
326424005158	putative PBP binding regions; other site
326424005159	Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141
326424005160	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
326424005161	Periplasmic binding protein TroA_e.  These proteins are predicted to function as initial receptors in the ABC metal ion uptake in eubacteria and archaea.  They belong to the TroA superfamily of helical backbone metal receptor proteins that share a...; Region: TroA_e; cd01142
326424005162	putative ligand binding residues [chemical binding]; other site
326424005163	Periplasmic binding protein; Region: Peripla_BP_2; pfam01497
326424005164	Galactose mutarotase and related enzymes [Carbohydrate transport and metabolism]; Region: GalM; COG2017
326424005165	Aldose 1-epimerase, similar to Escherichia coli YihR; Region: Aldose_epim_Ec_YihR; cd09022
326424005166	active site
326424005167	catalytic residues [active]
326424005168	NAD(P)H:flavin oxidoreductase-like family 1.  A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes; Region: NADPH_oxidoreductase_1; cd02150
326424005169	putative FMN binding site [chemical binding]; other site
326424005170	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
326424005171	Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer,  utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514
326424005172	FMN binding site [chemical binding]; other site
326424005173	Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer,  utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514
326424005174	dimer interface [polypeptide binding]; other site
326424005175	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
326424005176	active site
326424005177	metal binding site [ion binding]; metal-binding site
326424005178	NADPH-dependent FMN reductase; Region: FMN_red; cl00438
326424005179	Domain of unknown function (DUF1918); Region: DUF1918; pfam08940
326424005180	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
326424005181	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
326424005182	active site
326424005183	phosphorylation site [posttranslational modification]
326424005184	intermolecular recognition site; other site
326424005185	dimerization interface [polypeptide binding]; other site
326424005186	GAF domain; Region: GAF_2; pfam13185
326424005187	GAF domain; Region: GAF; cl15785
326424005188	PAS domain S-box; Region: sensory_box; TIGR00229
326424005189	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
326424005190	putative active site [active]
326424005191	heme pocket [chemical binding]; other site
326424005192	Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852
326424005193	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
326424005194	putative active site [active]
326424005195	heme pocket [chemical binding]; other site
326424005196	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
326424005197	dimer interface [polypeptide binding]; other site
326424005198	phosphorylation site [posttranslational modification]
326424005199	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
326424005200	ATP binding site [chemical binding]; other site
326424005201	Mg2+ binding site [ion binding]; other site
326424005202	G-X-G motif; other site
326424005203	Response regulator receiver domain; Region: Response_reg; pfam00072
326424005204	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
326424005205	active site
326424005206	phosphorylation site [posttranslational modification]
326424005207	intermolecular recognition site; other site
326424005208	dimerization interface [polypeptide binding]; other site
326424005209	Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381
326424005210	enoyl-CoA hydratase; Provisional; Region: PRK08252
326424005211	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
326424005212	substrate binding site [chemical binding]; other site
326424005213	oxyanion hole (OAH) forming residues; other site
326424005214	trimer interface [polypeptide binding]; other site
326424005215	Plasmid stabilisation system protein; Region: Plasmid_stabil; cl11422
326424005216	Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; cl09153
326424005217	oxidoreductase alpha (molybdopterin) subunit; Region: Fdhalpha-like; TIGR01701
326424005218	The MopB_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. These members belong to the molybdopterin_binding (MopB) superfamily of proteins; Region: MopB_ydeP; cd02767
326424005219	putative molybdopterin cofactor binding site [chemical binding]; other site
326424005220	The MopB_CT_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. This CD is of the conserved molybdopterin_binding C-terminal (MopB_CT) region...; Region: MopB_CT_ydeP; cd02787
326424005221	putative molybdopterin cofactor binding site; other site
326424005222	FdhD/NarQ family; Region: FdhD-NarQ; cl00659
326424005223	CYTH-like (also known as triphosphate tunnel metalloenzyme (TTM)-like) Phosphatases; Region: CYTH-like_Pase; cd07374
326424005224	putative active site; other site
326424005225	putative metal binding residues [ion binding]; other site
326424005226	signature motif; other site
326424005227	putative triphosphate binding site [ion binding]; other site
326424005228	CHAD domain; Region: CHAD; cl10506
326424005229	NADPH-dependent FMN reductase; Region: FMN_red; cl00438
326424005230	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
326424005231	probable F420-dependent oxidoreductase, Rv2161c family; Region: F420_Rv2161c; TIGR03619
326424005232	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
326424005233	Helix-turn-helix domains; Region: HTH; cl00088
326424005234	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
326424005235	Helix-turn-helix domains; Region: HTH; cl00088
326424005236	Tannase and feruloyl esterase; Region: Tannase; pfam07519
326424005237	Caspase, interleukin-1 beta converting enzyme (ICE) homologues; Cysteine-dependent aspartate-directed proteases that mediate programmed cell death (apoptosis). Caspases are synthesized as inactive zymogens and activated by proteolysis of the peptide...; Region: CASc; cl00042
326424005238	DNA helicase, putative; Region: TIGR00376
326424005239	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
326424005240	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
326424005241	Family description; Region: UvrD_C_2; cl15862
326424005242	3-ketoacyl-(acyl-carrier-protein) reductase; Reviewed; Region: PRK12826
326424005243	classical (c) SDRs; Region: SDR_c; cd05233
326424005244	NAD(P) binding site [chemical binding]; other site
326424005245	active site
326424005246	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
326424005247	Helix-turn-helix domains; Region: HTH; cl00088
326424005248	hypothetical protein; Provisional; Region: PRK07208
326424005249	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
326424005250	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
326424005251	Helix-turn-helix domains; Region: HTH; cl00088
326424005252	AefR-like transcriptional repressor, C-terminal region; Region: TetR_C_7; pfam14246
326424005253	Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670
326424005254	Domain of unknown function (DUF1707); Region: DUF1707; pfam08044
326424005255	Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_24; cd04683
326424005256	nudix motif; other site
326424005257	Periplasmic binding protein; Region: Peripla_BP_6; pfam13458
326424005258	Type I periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type active transport systems that are predicted to be involved in transport of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_7; cd06341
326424005259	putative ligand binding site [chemical binding]; other site
326424005260	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
326424005261	NAD(P) binding site [chemical binding]; other site
326424005262	active site
326424005263	Helix-turn-helix domains; Region: HTH; cl00088
326424005264	alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859
326424005265	3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084
326424005266	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
326424005267	Protein of unknown function, DUF488; Region: DUF488; cl01246
326424005268	Antibiotic biosynthesis monooxygenase; Region: ABM; cl10022
326424005269	Truncated hemoglobins (trHbs) are a family of oxygen-binding heme proteins found in cyanobacteria, eubacteria, unicellular eukaryotes, and plants. The truncated hemoglobins have a characteristic two-over-two alpha helical folding pattern that is distinct...; Region: Trunc_globin; cd00454
326424005270	apolar tunnel; other site
326424005271	heme binding site [chemical binding]; other site
326424005272	dimerization interface [polypeptide binding]; other site
326424005273	Helix-turn-helix domains; Region: HTH; cl00088
326424005274	Truncated hemoglobins (trHbs) are a family of oxygen-binding heme proteins found in cyanobacteria, eubacteria, unicellular eukaryotes, and plants. The truncated hemoglobins have a characteristic two-over-two alpha helical folding pattern that is distinct...; Region: Trunc_globin; cd00454
326424005275	apolar tunnel; other site
326424005276	heme binding site [chemical binding]; other site
326424005277	dimerization interface [polypeptide binding]; other site
326424005278	Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381
326424005279	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
326424005280	S-adenosylmethionine binding site [chemical binding]; other site
326424005281	putative FMN-dependent luciferase-like monooxygenase, KPN_01858 family; Region: LLM_KPN_01858; TIGR04027
326424005282	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
326424005283	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
326424005284	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
326424005285	Walker A/P-loop; other site
326424005286	ATP binding site [chemical binding]; other site
326424005287	Q-loop/lid; other site
326424005288	ABC transporter signature motif; other site
326424005289	Walker B; other site
326424005290	D-loop; other site
326424005291	H-loop/switch region; other site
326424005292	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
326424005293	ABC transporter transmembrane region; Region: ABC_membrane; cl00549
326424005294	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
326424005295	Walker A/P-loop; other site
326424005296	ATP binding site [chemical binding]; other site
326424005297	Q-loop/lid; other site
326424005298	ABC transporter signature motif; other site
326424005299	Walker B; other site
326424005300	D-loop; other site
326424005301	H-loop/switch region; other site
326424005302	Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094
326424005303	alkanesulfonate monooxygenase, FMNH(2)-dependent; Region: alk_sulf_monoox; TIGR03565
326424005304	dimer interface [polypeptide binding]; other site
326424005305	active site
326424005306	non-prolyl cis peptide bond; other site
326424005307	insertion regions; other site
326424005308	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
326424005309	AAA domain; Region: AAA_28; pfam13521
326424005310	Helix-turn-helix domains; Region: HTH; cl00088
326424005311	SAM-dependent methyltransferases [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: SmtA; COG0500
326424005312	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
326424005313	S-adenosylmethionine binding site [chemical binding]; other site
326424005314	Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064
326424005315	D-arabinose dehydrogenase; Region: arabinose_DH_like; cd05284
326424005316	NAD binding site [chemical binding]; other site
326424005317	substrate binding site [chemical binding]; other site
326424005318	catalytic Zn binding site [ion binding]; other site
326424005319	structural Zn binding site [ion binding]; other site
326424005320	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076
326424005321	Predicted HD superfamily hydrolase involved in NAD metabolism [Coenzyme metabolism]; Region: COG1713
326424005322	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
326424005323	PAS domain; Region: PAS_9; pfam13426
326424005324	putative active site [active]
326424005325	heme pocket [chemical binding]; other site
326424005326	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
326424005327	metal binding site [ion binding]; metal-binding site
326424005328	active site
326424005329	I-site; other site
326424005330	squalene-hopene cyclase; Region: hopene_cyclase; TIGR01507
326424005331	Squalene cyclase (SQCY) domain subgroup 1; found in class II terpene cyclases that have an alpha 6 - alpha 6 barrel fold. Squalene cyclase (SQCY)  and 2,3-oxidosqualene cyclase (OSQCY) are integral membrane proteins that catalyze a cationic cyclization...; Region: SQCY_1; cd02892
326424005332	Active site cavity [active]
326424005333	catalytic acid [active]
326424005334	mycofactocin system transcriptional regulator; Region: mycofact_TetR; TIGR03968
326424005335	Helix-turn-helix domains; Region: HTH; cl00088
326424005336	PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474
326424005337	Integrase core domain; Region: rve; cl01316
326424005338	DDE domain; Region: DDE_Tnp_IS240; pfam13610
326424005339	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585
326424005340	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
326424005341	ATP binding site [chemical binding]; other site
326424005342	Mg2+ binding site [ion binding]; other site
326424005343	G-X-G motif; other site
326424005344	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632
326424005345	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
326424005346	active site
326424005347	metal binding site [ion binding]; metal-binding site
326424005348	Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109
326424005349	Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_7; cd07825
326424005350	putative hydrophobic ligand binding site [chemical binding]; other site
326424005351	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
326424005352	non-specific DNA binding site [nucleotide binding]; other site
326424005353	salt bridge; other site
326424005354	sequence-specific DNA binding site [nucleotide binding]; other site
326424005355	Predicted ATPase [General function prediction only]; Region: COG3903
326424005356	classical (c) SDRs; Region: SDR_c; cd05233
326424005357	NAD(P) binding site [chemical binding]; other site
326424005358	active site
326424005359	SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339
326424005360	SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339
326424005361	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
326424005362	NAD(P) binding site [chemical binding]; other site
326424005363	active site
326424005364	Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804
326424005365	CoA-transferase family III; Region: CoA_transf_3; pfam02515
326424005366	Predicted nucleic-acid-binding protein containing a Zn-ribbon [General function prediction only]; Region: COG1545
326424005367	Rubredoxin-like zinc ribbon domain (DUF35_N); Region: DUF35_N; pfam12172
326424005368	DUF35 OB-fold domain; Region: DUF35; pfam01796
326424005369	acetyl-CoA acetyltransferase; Provisional; Region: PRK08313
326424005370	Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2  has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829
326424005371	active site
326424005372	(R)-hydratase [(R)-specific enoyl-CoA hydratase]. Catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway.  The structure of the monomer includes a five-strand antiparallel...; Region: R_hydratase_like; cd03441
326424005373	active site
326424005374	catalytic site [active]
326424005375	The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509
326424005376	active site 2 [active]
326424005377	active site 1 [active]
326424005378	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
326424005379	Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771
326424005380	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
326424005381	active site
326424005382	Putative acyl-CoA dehydrogenases similar to fadE6, fadE17, and fadE26; Region: ACAD_fadE6_17_26; cd01152
326424005383	pimeloyl-CoA dehydrogenase, large subunit; Region: pimC_large; TIGR03204
326424005384	FAD binding site [chemical binding]; other site
326424005385	substrate binding site [chemical binding]; other site
326424005386	catalytic base [active]
326424005387	acetyl-CoA acetyltransferase; Provisional; Region: PRK07801
326424005388	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
326424005389	dimer interface [polypeptide binding]; other site
326424005390	active site
326424005391	Pyrabactin resistance 1 (PYR1), PYR1-like (PYL), regulatory component of abscisic acid receptors (RCARs), and related proteins; Region: PYR_PYL_RCAR_like; cd07821
326424005392	putative hydrophobic ligand binding site [chemical binding]; other site
326424005393	protein interface [polypeptide binding]; other site
326424005394	gate; other site
326424005395	AMP-binding enzyme; Region: AMP-binding; cl15778
326424005396	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
326424005397	probable F420-dependent oxidoreductase, Rv2161c family; Region: F420_Rv2161c; TIGR03619
326424005398	3-ketoacyl-(acyl-carrier-protein) reductase; Reviewed; Region: PRK12826
326424005399	classical (c) SDRs; Region: SDR_c; cd05233
326424005400	NAD(P) binding site [chemical binding]; other site
326424005401	active site
326424005402	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
326424005403	Helix-turn-helix domains; Region: HTH; cl00088
326424005404	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
326424005405	Domain of unknown function DUF59; Region: DUF59; cl00941
326424005406	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
326424005407	3-ketoacyl-(acyl-carrier-protein) reductase; Reviewed; Region: PRK12826
326424005408	classical (c) SDRs; Region: SDR_c; cd05233
326424005409	NAD(P) binding site [chemical binding]; other site
326424005410	active site
326424005411	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
326424005412	TM-ABC transporter signature motif; other site
326424005413	ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129
326424005414	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
326424005415	Walker A/P-loop; other site
326424005416	ATP binding site [chemical binding]; other site
326424005417	Q-loop/lid; other site
326424005418	ABC transporter signature motif; other site
326424005419	Walker B; other site
326424005420	D-loop; other site
326424005421	H-loop/switch region; other site
326424005422	This family represents domain II of the carbohydrate uptake proteins that transport only monosaccharides (Monos).  The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and hexoses; Region: ABC_Carb_Monos_II; cd03215
326424005423	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
326424005424	Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826
326424005425	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316
326424005426	HTH-like domain; Region: HTH_21; pfam13276
326424005427	Helix-turn-helix domains; Region: HTH; cl00088
326424005428	Bacterial transcriptional activator domain; Region: BTAD; pfam03704
326424005429	NB-ARC domain; Region: NB-ARC; pfam00931
326424005430	Tetratricopeptide repeat; Region: TPR_12; pfam13424
326424005431	Tetratricopeptide repeat; Region: TPR_12; pfam13424
326424005432	ATP-grasp domain; Region: ATP-grasp_4; cl03087
326424005433	Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381
326424005434	crotonyl-CoA reductase; Region: crot-CoA-red; TIGR01751
326424005435	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
326424005436	NAD(P) binding site [chemical binding]; other site
326424005437	MbtH-like protein; Region: MbtH; cl01279
326424005438	Phage integrase, N-terminal SAM-like domain; Region: Phage_integr_N; cl12235
326424005439	Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318
326424005440	AMP-binding enzyme; Region: AMP-binding; cl15778
326424005441	Phosphopantetheine attachment site; Region: PP-binding; cl09936
326424005442	Dehydrogenases (flavoproteins) [Energy production and conversion]; Region: FixC; COG0644
326424005443	peptide synthase; Provisional; Region: PRK12467
326424005444	HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745
326424005445	AMP-binding enzyme; Region: AMP-binding; cl15778
326424005446	non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261
326424005447	AMP-binding enzyme; Region: AMP-binding; cl15778
326424005448	Phosphopantetheine attachment site; Region: PP-binding; cl09936
326424005449	peptide synthase; Provisional; Region: PRK12467
326424005450	HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745
326424005451	AMP-binding enzyme; Region: AMP-binding; cl15778
326424005452	AMP-binding enzyme; Region: AMP-binding; cl15778
326424005453	Phosphopantetheine attachment site; Region: PP-binding; cl09936
326424005454	non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261
326424005455	AMP-binding enzyme; Region: AMP-binding; cl15778
326424005456	Phosphopantetheine attachment site; Region: PP-binding; cl09936
326424005457	Condensation domain; Region: Condensation; pfam00668
326424005458	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
326424005459	HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745
326424005460	AMP-binding enzyme; Region: AMP-binding; cl15778
326424005461	acetyl-CoA synthetase; Provisional; Region: PRK00174
326424005462	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
326424005463	S-adenosylmethionine binding site [chemical binding]; other site
326424005464	Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318
326424005465	enterobactin synthase subunit F; Provisional; Region: entF; PRK10252
326424005466	Phosphopantetheine attachment site; Region: PP-binding; cl09936
326424005467	Predicted thioesterase involved in non-ribosomal peptide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: GrsT; COG3208
326424005468	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
326424005469	daunorubicin resistance ABC transporter ATP-binding subunit; Region: drrA; TIGR01188
326424005470	Walker A/P-loop; other site
326424005471	ATP binding site [chemical binding]; other site
326424005472	Q-loop/lid; other site
326424005473	ABC transporter signature motif; other site
326424005474	Walker B; other site
326424005475	D-loop; other site
326424005476	H-loop/switch region; other site
326424005477	Domain of unknown function (DUF4162); Region: DUF4162; pfam13732
326424005478	ABC-2 type transporter; Region: ABC2_membrane; cl11417
326424005479	2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy; cl15773
326424005480	Phosphopantetheine attachment site; Region: PP-binding; cl09936
326424005481	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; cl12078
326424005482	Predicted thioesterase involved in non-ribosomal peptide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: GrsT; COG3208
326424005483	polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833
326424005484	Beta-ketoacyl synthase; Region: PKS_KS; smart00825
326424005485	active site
326424005486	malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128
326424005487	Acyl transferase domain; Region: Acyl_transf_1; cl08282
326424005488	Phosphopantetheine attachment site; Region: PP-binding; cl09936
326424005489	Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321
326424005490	polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833
326424005491	active site
326424005492	Acyl transferase domain; Region: Acyl_transf_1; cl08282
326424005493	Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826
326424005494	beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 3, complex (x); Region: KR_3_FAS_SDR_x; cd08956
326424005495	putative NADP binding site [chemical binding]; other site
326424005496	active site
326424005497	Phosphopantetheine attachment site; Region: PP-binding; cl09936
326424005498	Erythronolide synthase docking; Region: Docking; pfam08990
326424005499	Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321
326424005500	polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833
326424005501	active site
326424005502	Acyl transferase domain; Region: Acyl_transf_1; cl08282
326424005503	Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826
326424005504	beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 3, complex (x); Region: KR_3_FAS_SDR_x; cd08956
326424005505	enoyl reductase of polyketide synthase; Region: enoyl_red; cd05195
326424005506	Enoylreductase; Region: PKS_ER; smart00829
326424005507	NAD(P) binding site [chemical binding]; other site
326424005508	beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 3, complex (x); Region: KR_3_FAS_SDR_x; cd08956
326424005509	putative NADP binding site [chemical binding]; other site
326424005510	active site
326424005511	Phosphopantetheine attachment site; Region: PP-binding; cl09936
326424005512	polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833
326424005513	3-oxoacyl-acyl carrier protein synthase; Provisional; Region: PTZ00050
326424005514	active site
326424005515	malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128
326424005516	Acyl transferase domain; Region: Acyl_transf_1; cl08282
326424005517	Phosphopantetheine attachment site; Region: PP-binding; cl09936
326424005518	peptide synthase; Provisional; Region: PRK12316
326424005519	AMP-binding enzyme; Region: AMP-binding; cl15778
326424005520	Phosphopantetheine attachment site; Region: PP-binding; cl09936
326424005521	hypothetical protein; Provisional; Region: PRK06834
326424005522	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
326424005523	L-lysine 6-monooxygenase (NADPH-requiring); Region: K_oxygenase; pfam13434
326424005524	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
326424005525	Domain of unknown function (DUF4098); Region: DUF4098; pfam13345
326424005526	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
326424005527	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
326424005528	Pentapeptide repeats containing protein [Function unknown]; Region: COG1357
326424005529	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
326424005530	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
326424005531	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
326424005532	Helix-turn-helix domains; Region: HTH; cl00088
326424005533	prephenate dehydrogenase; Validated; Region: PRK06545
326424005534	ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141
326424005535	Recombinase; Region: Recombinase; pfam07508
326424005536	Evidence 7 : Gene remnant
326424005537	Evidence 7 : Gene remnant
326424005538	Evidence 7 : Gene remnant
326424005539	mycofactocin system glycosyltransferase; Region: actino_glycTran; TIGR03965
326424005540	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
326424005541	active site
326424005542	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
326424005543	S-adenosylmethionine binding site [chemical binding]; other site
326424005544	extended (e) SDRs; Region: SDR_e; cd08946
326424005545	active site
326424005546	radical SAM enzyme, rSAM/lipoprotein system; Region: rSAM_w_lipo; TIGR04133
326424005547	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
326424005548	FeS/SAM binding site; other site
326424005549	Domain of unknown function (DUF4008); Region: DUF4008; cl14869
326424005550	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
326424005551	NAD(P) binding site [chemical binding]; other site
326424005552	active site
326424005553	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
326424005554	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
326424005555	active site
326424005556	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
326424005557	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
326424005558	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
326424005559	DNA binding residues [nucleotide binding]
326424005560	dimerization interface [polypeptide binding]; other site
326424005561	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
326424005562	Epoxide hydrolase N terminus; Region: EHN; pfam06441
326424005563	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
326424005564	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
326424005565	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557
326424005566	Transcriptional regulators [Transcription]; Region: MarR; COG1846
326424005567	Helix-turn-helix domains; Region: HTH; cl00088
326424005568	Helix-turn-helix domains; Region: HTH; cl00088
326424005569	Helix-turn-helix domains; Region: HTH; cl00088
326424005570	ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346
326424005571	Clp amino terminal domain; Region: Clp_N; pfam02861
326424005572	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
326424005573	Walker A motif; other site
326424005574	ATP binding site [chemical binding]; other site
326424005575	Walker B motif; other site
326424005576	arginine finger; other site
326424005577	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
326424005578	Walker A motif; other site
326424005579	ATP binding site [chemical binding]; other site
326424005580	Walker B motif; other site
326424005581	arginine finger; other site
326424005582	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; cl11083
326424005583	MerR HTH family regulatory protein; Region: MerR_2; pfam13591
326424005584	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
326424005585	HSP70 interaction site [polypeptide binding]; other site
326424005586	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747
326424005587	substrate binding site [polypeptide binding]; other site
326424005588	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262
326424005589	dimer interface [polypeptide binding]; other site
326424005590	GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446
326424005591	dimer interface [polypeptide binding]; other site
326424005592	hsp70 (ATPase domain) interactions [polypeptide binding]; other site
326424005593	molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290
326424005594	Domain of unknown function (DUF1931); Region: DUF1931; pfam09123
326424005595	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
326424005596	ligand binding site [chemical binding]; other site
326424005597	thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292
326424005598	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
326424005599	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
326424005600	cyclohexanecarboxylate-CoA ligase; Reviewed; Region: PRK13295
326424005601	AMP-binding enzyme; Region: AMP-binding; cl15778
326424005602	Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804
326424005603	CoA-transferase family III; Region: CoA_transf_3; pfam02515
326424005604	CoA-transferase family III; Region: CoA_transf_3; pfam02515
326424005605	Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804
326424005606	formyl-CoA transferase; Region: oxalate_frc; TIGR03253
326424005607	long-chain-fatty-acid--CoA ligase; Validated; Region: PRK08314
326424005608	AMP-binding enzyme; Region: AMP-binding; cl15778
326424005609	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
326424005610	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
326424005611	putative acyltransferase; Provisional; Region: PRK05790
326424005612	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
326424005613	dimer interface [polypeptide binding]; other site
326424005614	active site
326424005615	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009
326424005616	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
326424005617	active site
326424005618	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
326424005619	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
326424005620	active site
326424005621	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410
326424005622	LivF (TM1139) is part of the LIV-I bacterial ABC-type two-component transport system that imports neutral, branched-chain amino acids.  The  E. coli branched-chain amino acid transporter comprises a heterodimer of ABC transporters (LivF and LivG), a...; Region: ABC_TM1139_LivF_branched; cd03224
326424005623	Walker A/P-loop; other site
326424005624	ATP binding site [chemical binding]; other site
326424005625	Q-loop/lid; other site
326424005626	ABC transporter signature motif; other site
326424005627	Walker B; other site
326424005628	D-loop; other site
326424005629	H-loop/switch region; other site
326424005630	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
326424005631	TM-ABC transporter signature motif; other site
326424005632	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
326424005633	TM-ABC transporter signature motif; other site
326424005634	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411
326424005635	The Mj1267/LivG ABC transporter subfamily is involved in the transport of the hydrophobic amino acids leucine, isoleucine and valine.  MJ1267 is a branched-chain amino acid transporter with 29% similarity to both the LivF and LivG components of the E; Region: ABC_Mj1267_LivG_branched; cd03219
326424005636	Walker A/P-loop; other site
326424005637	ATP binding site [chemical binding]; other site
326424005638	Q-loop/lid; other site
326424005639	ABC transporter signature motif; other site
326424005640	Walker B; other site
326424005641	D-loop; other site
326424005642	H-loop/switch region; other site
326424005643	Periplasmic binding protein; Region: Peripla_BP_6; pfam13458
326424005644	Type I periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type active transport systems that are predicted to be involved in transport of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_7; cd06341
326424005645	putative ligand binding site [chemical binding]; other site
326424005646	cyclohexanecarboxyl-CoA dehydrogenase; Region: cyc_hxne_CoA_dh; TIGR03207
326424005647	Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771
326424005648	Acyl-CoA dehydrogenase, middle domain; Region: Acyl-CoA_dh_M; pfam02770
326424005649	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
326424005650	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
326424005651	Helix-turn-helix domains; Region: HTH; cl00088
326424005652	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
326424005653	enoyl-CoA hydratase; Provisional; Region: PRK06688
326424005654	substrate binding site [chemical binding]; other site
326424005655	oxyanion hole (OAH) forming residues; other site
326424005656	trimer interface [polypeptide binding]; other site
326424005657	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cl15762
326424005658	DUF35 OB-fold domain; Region: DUF35; pfam01796
326424005659	lipid-transfer protein; Provisional; Region: PRK08256
326424005660	Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2  has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829
326424005661	active site
326424005662	cyclohexanecarboxylate-CoA ligase; Reviewed; Region: PRK13295
326424005663	AMP-binding enzyme; Region: AMP-binding; cl15778
326424005664	gamma-glutamyl-gamma-aminobutyraldehyde dehydrogenase; Provisional; Region: PRK09847
326424005665	Rhodococcus ruber 6-oxolauric acid dehydrogenase-like and related proteins; Region: ALDH_CddD-AldA-like; cd07089
326424005666	NAD binding site [chemical binding]; other site
326424005667	catalytic residues [active]
326424005668	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
326424005669	classical (c) SDRs; Region: SDR_c; cd05233
326424005670	NAD(P) binding site [chemical binding]; other site
326424005671	active site
326424005672	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
326424005673	Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2  has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829
326424005674	acetyl-CoA acetyltransferase; Provisional; Region: PRK08142
326424005675	active site
326424005676	Rubredoxin-like zinc ribbon domain (DUF35_N); Region: DUF35_N; pfam12172
326424005677	DUF35 OB-fold domain; Region: DUF35; pfam01796
326424005678	Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804
326424005679	CoA-transferase family III; Region: CoA_transf_3; pfam02515
326424005680	Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804
326424005681	CoA-transferase family III; Region: CoA_transf_3; pfam02515
326424005682	Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752
326424005683	Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396
326424005684	Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378
326424005685	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
326424005686	substrate binding site [chemical binding]; other site
326424005687	oxyanion hole (OAH) forming residues; other site
326424005688	trimer interface [polypeptide binding]; other site
326424005689	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557
326424005690	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
326424005691	NAD(P) binding site [chemical binding]; other site
326424005692	active site
326424005693	Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403
326424005694	active site
326424005695	NTP binding site [chemical binding]; other site
326424005696	metal binding triad [ion binding]; metal-binding site
326424005697	antibiotic binding site [chemical binding]; other site
326424005698	AAA-like domain; Region: AAA_10; pfam12846
326424005699	Domain of unknown function DUF87; Region: DUF87; pfam01935
326424005700	TraM recognition site of TraD and TraG; Region: TraG-D_C; pfam12696
326424005701	Restriction endonuclease; Region: Mrr_cat; cl00516
326424005702	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
326424005703	active site
326424005704	ATP binding site [chemical binding]; other site
326424005705	substrate binding site [chemical binding]; other site
326424005706	activation loop (A-loop); other site
326424005707	Catalytic domain of Protein Kinases; Region: PKc; cd00180
326424005708	active site
326424005709	ATP binding site [chemical binding]; other site
326424005710	substrate binding site [chemical binding]; other site
326424005711	activation loop (A-loop); other site
326424005712	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
326424005713	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
326424005714	Transposase domain (DUF772); Region: DUF772; cl15789
326424005715	Transposase; Region: DEDD_Tnp_IS110; pfam01548
326424005716	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
326424005717	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
326424005718	DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182
326424005719	DNA binding site [nucleotide binding]
326424005720	active site
326424005721	Int/Topo IB signature motif; other site
326424005722	catalytic residues [active]
326424005723	C1 Peptidase family (MEROPS database nomenclature), also referred to as the papain family; composed of two subfamilies of cysteine peptidases (CPs), C1A (papain) and C1B (bleomycin hydrolase). Papain-like enzymes are mostly endopeptidases with some...; Region: Peptidase_C1; cl00298
326424005724	active site
326424005725	Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cl02712
326424005726	Laminarinase, member of the glycosyl hydrolase family 16; Region: GH16_laminarinase_like; cd08023
326424005727	active site
326424005728	catalytic residues [active]
326424005729	Activation domain of S53 peptidases; Region: Pro-peptidase_S53; cd11377
326424005730	peptidase domain interface [polypeptide binding]; other site
326424005731	Peptidase domain in the S53 family; Region: Peptidases_S53; cd04056
326424005732	active site
326424005733	catalytic triad [active]
326424005734	calcium binding site [ion binding]; other site
326424005735	Phage-related minor tail protein; Region: PhageMin_Tail; pfam10145
326424005736	Phage-related protein [Function unknown]; Region: COG5412
326424005737	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic 'goose-type' lysozymes (GEWL).  LTs catalyze...; Region: LT_GEWL; cd00254
326424005738	N-acetyl-D-glucosamine binding site [chemical binding]; other site
326424005739	catalytic residue [active]
326424005740	SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229
326424005741	active site
326424005742	catalytic triad [active]
326424005743	Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of...; Region: LamG; cl00102
326424005744	bifunctional glutamine-synthetase adenylyltransferase/deadenyltransferase; Reviewed; Region: PRK11072
326424005745	hypothetical protein; Provisional; Region: PRK07740
326424005746	cell division protein ZipA; Provisional; Region: PRK03427
326424005747	Protein of unknown function (DUF1360); Region: DUF1360; pfam07098
326424005748	Protein-L-isoaspartate carboxylmethyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: Pcm; COG2518
326424005749	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
326424005750	S-adenosylmethionine binding site [chemical binding]; other site
326424005751	SpaB C-terminal domain; Region: SpaB_C; cl14828
326424005752	Lanthionine synthetase C-like protein; Region: LANC_like; pfam05147
326424005753	LanC-like proteins. LanC is the cyclase enzyme of the lanthionine synthetase. Lanthionine is a lantibiotic, a unique class of peptide antibiotics. They are ribosomally synthesized as a precursor peptide and then post-translationally modified to contain...; Region: LanC_like; cl04955
326424005754	active site
326424005755	zinc binding site [ion binding]; other site
326424005756	Lantibiotic dehydratase, N terminus; Region: Lant_dehyd_N; pfam04737
326424005757	Lantibiotic dehydratase, C terminus; Region: Lant_dehyd_C; pfam04738
326424005758	SpaB C-terminal domain; Region: SpaB_C; cl14828
326424005759	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
326424005760	S-adenosylmethionine binding site [chemical binding]; other site
326424005761	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
326424005762	non-specific DNA binding site [nucleotide binding]; other site
326424005763	salt bridge; other site
326424005764	sequence-specific DNA binding site [nucleotide binding]; other site
326424005765	Adenylyl cyclase (AC) class IV-like, a subgroup of the CYTH-like superfamily; Region: CYTH-like_AC_IV-like; cd07890
326424005766	putative active site [active]
326424005767	putative metal binding residues [ion binding]; other site
326424005768	signature motif; other site
326424005769	putative triphosphate binding site [ion binding]; other site
326424005770	dimer interface [polypeptide binding]; other site
326424005771	Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490
326424005772	putative catalytic site [active]
326424005773	putative phosphate binding site [ion binding]; other site
326424005774	putative metal binding site [ion binding]; other site
326424005775	Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672
326424005776	TMP-binding site; other site
326424005777	Predicted Fe-S oxidoreductases [General function prediction only]; Region: COG0535
326424005778	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
326424005779	FeS/SAM binding site; other site
326424005780	Domain of unknown function (DUF4008); Region: DUF4008; cl14869
326424005781	Transcriptional regulator [Transcription]; Region: LysR; COG0583
326424005782	Helix-turn-helix domains; Region: HTH; cl00088
326424005783	DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127
326424005784	active site
326424005785	substrate binding site [chemical binding]; other site
326424005786	catalytic site [active]
326424005787	S-adenosyl methyltransferase; Region: Methyltransf_19; pfam04672
326424005788	hypothetical protein; Provisional; Region: PRK08317
326424005789	Predicted metal-dependent phosphoesterases (PHP family) [General function prediction only]; Region: COG0613
326424005790	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
326424005791	ligand binding site [chemical binding]; other site
326424005792	flexible hinge region; other site
326424005793	Helix-turn-helix domains; Region: HTH; cl00088
326424005794	ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192
326424005795	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
326424005796	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
326424005797	ligand binding site [chemical binding]; other site
326424005798	flexible hinge region; other site
326424005799	Helix-turn-helix domains; Region: HTH; cl00088
326424005800	imidazoleglycerol-phosphate dehydratase; Validated; Region: hisB; PRK00951
326424005801	Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914
326424005802	putative active site pocket [active]
326424005803	4-fold oligomerization interface [polypeptide binding]; other site
326424005804	metal binding residues [ion binding]; metal-binding site
326424005805	3-fold/trimer interface [polypeptide binding]; other site
326424005806	Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490
326424005807	putative metal binding site [ion binding]; other site
326424005808	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
326424005809	non-specific DNA binding site [nucleotide binding]; other site
326424005810	salt bridge; other site
326424005811	sequence-specific DNA binding site [nucleotide binding]; other site
326424005812	Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1),  6-pyrovoyl...; Region: TFold; cl00263
326424005813	active site
326424005814	4Fe-4S single cluster domain; Region: Fer4_14; pfam13394
326424005815	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
326424005816	FeS/SAM binding site; other site
326424005817	Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1),  6-pyrovoyl...; Region: TFold; cl00263
326424005818	active site
326424005819	Oxygenase domain of the 2OGFeDO superfamily; Region: Tet_JBP; pfam12851
326424005820	Domain of unknown function (DUF932); Region: DUF932; cl12129
326424005821	Domain of unknown function (DUF3560); Region: DUF3560; pfam12083
326424005822	Helix-Turn-Helix DNA binding domain of truncated MerR-like proteins; Region: HTH_MerR-trunc; cd04762
326424005823	DNA binding residues [nucleotide binding]
326424005824	Helix-turn-helix domains; Region: HTH; cl00088
326424005825	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761
326424005826	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
326424005827	Site-specific recombinase XerD [DNA replication, recombination, and repair]; Region: XerD; COG4974
326424005828	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
326424005829	DNA binding site [nucleotide binding]
326424005830	Int/Topo IB signature motif; other site
326424005831	active site
326424005832	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
326424005833	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
326424005834	active site
326424005835	Helix-turn-helix domains; Region: HTH; cl00088
326424005836	Putative peptidoglycan binding domain; Region: PG_binding_1; cl15437
326424005837	Putative peptidoglycan binding domain; Region: PG_binding_1; cl15437
326424005838	Protein of unknown function (DUF2889); Region: DUF2889; pfam11136
326424005839	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
326424005840	putative glycoprotease GCP; Region: bact_gcp; TIGR03723
326424005841	Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl14000
326424005842	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153
326424005843	metal binding site 2 [ion binding]; metal-binding site
326424005844	putative DNA binding helix; other site
326424005845	metal binding site 1 [ion binding]; metal-binding site
326424005846	structural Zn2+ binding site [ion binding]; other site
326424005847	Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487
326424005848	active site
326424005849	catalytic residues [active]
326424005850	metal binding site [ion binding]; metal-binding site
326424005851	probable F420-dependent oxidoreductase, MSMEG_2516 family; Region: F420_MSMEG_2516; TIGR03621
326424005852	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
326424005853	FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277
326424005854	FAD binding domain; Region: FAD_binding_4; pfam01565
326424005855	Precorrin-3B methylase [Coenzyme metabolism]; Region: CobJ; cl00304
326424005856	Tetrapyrrole (Corrin/Porphyrin) Methylases; Region: TP_methylase; pfam00590
326424005857	Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA; cl00391
326424005858	active site clefts [active]
326424005859	zinc binding site [ion binding]; other site
326424005860	dimer interface [polypeptide binding]; other site
326424005861	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
326424005862	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
326424005863	3-hydroxyisobutyryl-CoA hydrolase; Provisional; Region: PRK05617
326424005864	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
326424005865	substrate binding site [chemical binding]; other site
326424005866	oxyanion hole (OAH) forming residues; other site
326424005867	trimer interface [polypeptide binding]; other site
326424005868	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cl15762
326424005869	Domain of unknown function (DUF222); Region: DUF222; pfam02720
326424005870	Domain of unknown function (DUF397); Region: DUF397; pfam04149
326424005871	Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338
326424005872	catalytic residues [active]
326424005873	catalytic nucleophile [active]
326424005874	Recombinase; Region: Recombinase; pfam07508
326424005875	Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408
326424005876	ABC-type oligopeptide transport system, ATPase component [Amino acid transport and metabolism]; Region: AppF; COG4608
326424005877	The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE).  The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257
326424005878	Walker A/P-loop; other site
326424005879	ATP binding site [chemical binding]; other site
326424005880	Q-loop/lid; other site
326424005881	ABC transporter signature motif; other site
326424005882	Walker B; other site
326424005883	D-loop; other site
326424005884	H-loop/switch region; other site
326424005885	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
326424005886	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444
326424005887	The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE).  The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257
326424005888	Walker A/P-loop; other site
326424005889	ATP binding site [chemical binding]; other site
326424005890	Q-loop/lid; other site
326424005891	ABC transporter signature motif; other site
326424005892	Walker B; other site
326424005893	D-loop; other site
326424005894	H-loop/switch region; other site
326424005895	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
326424005896	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
326424005897	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
326424005898	dimer interface [polypeptide binding]; other site
326424005899	conserved gate region; other site
326424005900	putative PBP binding loops; other site
326424005901	ABC-ATPase subunit interface; other site
326424005902	The substrate-binding domain of an oligopeptide binding protein (OppA2) from the biosynthesis pathway of the beta-lactamase inhibitor clavulanic acid contains the type 2 periplasmic binding fold; Region: PBP2_clavulanate_OppA2; cd08506
326424005903	peptide binding site [polypeptide binding]; other site
326424005904	Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496
326424005905	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
326424005906	dimer interface [polypeptide binding]; other site
326424005907	conserved gate region; other site
326424005908	putative PBP binding loops; other site
326424005909	ABC-ATPase subunit interface; other site
326424005910	Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; Region: SRPBCC_CalC_Aha1-like_6; cd08899
326424005911	putative hydrophobic ligand binding site [chemical binding]; other site
326424005912	hypothetical protein; Provisional; Region: PRK07906
326424005913	M20 Peptidase, carboxypeptidase yscS-like; Region: M20_yscS_like; cd05675
326424005914	putative metal binding site [ion binding]; other site
326424005915	Rubredoxin-like zinc ribbon domain (DUF35_N); Region: DUF35_N; pfam12172
326424005916	DUF35 OB-fold domain; Region: DUF35; pfam01796
326424005917	lipid-transfer protein; Provisional; Region: PRK07855
326424005918	Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2  has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829
326424005919	active site
326424005920	CoA-transferase family III; Region: CoA_transf_3; pfam02515
326424005921	CoA-transferase family III; Region: CoA_transf_3; pfam02515
326424005922	formyl-coenzyme A transferase; Provisional; Region: PRK05398
326424005923	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
326424005924	active site
326424005925	Transcriptional regulators [Transcription]; Region: FadR; COG2186
326424005926	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
326424005927	DNA-binding site [nucleotide binding]; DNA binding site
326424005928	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
326424005929	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557
326424005930	NAD(P) binding site [chemical binding]; other site
326424005931	active site
326424005932	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
326424005933	active site
326424005934	(R)-hydratase [(R)-specific enoyl-CoA hydratase]. Catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway.  The structure of the monomer includes a five-strand antiparallel...; Region: R_hydratase_like; cd03441
326424005935	active site
326424005936	catalytic site [active]
326424005937	The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509
326424005938	active site 2 [active]
326424005939	active site 1 [active]
326424005940	probable F420-dependent oxidoreductase, Rv3520c family; Region: F420_Rv3520c; TIGR03559
326424005941	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
326424005942	N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097
326424005943	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
326424005944	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
326424005945	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
326424005946	active site
326424005947	long-chain-fatty-acid--CoA ligase; Validated; Region: PRK08276
326424005948	AMP-binding enzyme; Region: AMP-binding; cl15778
326424005949	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
326424005950	Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446
326424005951	probable F420-dependent oxidoreductase, Rv3520c family; Region: F420_Rv3520c; TIGR03559
326424005952	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
326424005953	N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097
326424005954	Periplasmic binding protein; Region: Peripla_BP_6; pfam13458
326424005955	Type I periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type active transport systems that are predicted to be involved in transport of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_7; cd06341
326424005956	putative ligand binding site [chemical binding]; other site
326424005957	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410
326424005958	LivF (TM1139) is part of the LIV-I bacterial ABC-type two-component transport system that imports neutral, branched-chain amino acids.  The  E. coli branched-chain amino acid transporter comprises a heterodimer of ABC transporters (LivF and LivG), a...; Region: ABC_TM1139_LivF_branched; cd03224
326424005959	Walker A/P-loop; other site
326424005960	ATP binding site [chemical binding]; other site
326424005961	Q-loop/lid; other site
326424005962	ABC transporter signature motif; other site
326424005963	Walker B; other site
326424005964	D-loop; other site
326424005965	H-loop/switch region; other site
326424005966	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
326424005967	TM-ABC transporter signature motif; other site
326424005968	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
326424005969	TM-ABC transporter signature motif; other site
326424005970	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411
326424005971	The Mj1267/LivG ABC transporter subfamily is involved in the transport of the hydrophobic amino acids leucine, isoleucine and valine.  MJ1267 is a branched-chain amino acid transporter with 29% similarity to both the LivF and LivG components of the E; Region: ABC_Mj1267_LivG_branched; cd03219
326424005972	Walker A/P-loop; other site
326424005973	ATP binding site [chemical binding]; other site
326424005974	Q-loop/lid; other site
326424005975	ABC transporter signature motif; other site
326424005976	Walker B; other site
326424005977	D-loop; other site
326424005978	H-loop/switch region; other site
326424005979	Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl15769
326424005980	hypothetical protein; Provisional; Region: PRK07208
326424005981	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
326424005982	Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl15769
326424005983	helicase, putative, RecD/TraA family; Region: recD_rel; TIGR01448
326424005984	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
326424005985	Family description; Region: UvrD_C_2; cl15862
326424005986	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
326424005987	catalytic core [active]
326424005988	Protein of unknown function (DUF3090); Region: DUF3090; cl12832
326424005989	Phosphoinositide 3-kinase (PI3K)-like family, catalytic domain; The PI3K-like catalytic domain family is part of a larger superfamily that includes the catalytic domains of other kinases such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: PI3Kc_like; cl00119
326424005990	cysteinyl-tRNA synthetase; Provisional; Region: PRK12418
326424005991	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
326424005992	active site
326424005993	HIGH motif; other site
326424005994	nucleotide binding site [chemical binding]; other site
326424005995	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
326424005996	active site
326424005997	KMSKS motif; other site
326424005998	DivIVA protein; Region: DivIVA; pfam05103
326424005999	PAC2 family; Region: PAC2; cl00847
326424006000	beta-phosphoglucomutase family hydrolase; Region: PGMB-YQAB-SF; TIGR02009
326424006001	Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391
326424006002	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
326424006003	motif II; other site
326424006004	Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277
326424006005	putative active site [active]
326424006006	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
326424006007	FtsX-like permease family; Region: FtsX; cl15850
326424006008	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
326424006009	ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591
326424006010	FtsX-like permease family; Region: FtsX; cl15850
326424006011	This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE).  They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255
326424006012	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
326424006013	Walker A/P-loop; other site
326424006014	ATP binding site [chemical binding]; other site
326424006015	Q-loop/lid; other site
326424006016	ABC transporter signature motif; other site
326424006017	Walker B; other site
326424006018	D-loop; other site
326424006019	H-loop/switch region; other site
326424006020	CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641
326424006021	SpoIVFB Site-2 protease (S2P), a zinc metalloprotease (MEROPS family M50B), regulates intramembrane proteolysis (RIP), and is involved in the pro-sigmaK pathway of bacterial spore formation. In this subgroup, SpoIVFB (sporulation protein, stage IV cell...; Region: S2P-M50_SpoIVFB_CBS; cd06164
326424006022	active site
326424006023	putative substrate binding region [chemical binding]; other site
326424006024	tRNA(1-methyladenosine) methyltransferase and related methyltransferases [Translation, ribosomal structure and biogenesis]; Region: GCD14; COG2519
326424006025	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
326424006026	4Fe-4S single cluster domain; Region: Fer4_15; pfam13459
326424006027	proteasome ATPase; Region: pup_AAA; TIGR03689
326424006028	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
326424006029	Walker A motif; other site
326424006030	ATP binding site [chemical binding]; other site
326424006031	Walker B motif; other site
326424006032	arginine finger; other site
326424006033	Pup-ligase protein; Region: Pup_ligase; cl15463
326424006034	Pup-like protein; Region: Pup; cl05289
326424006035	proteasome_protease_HslV. This group contains the eukaryotic proteosome alpha and beta subunits and the prokaryotic protease hslV subunit. Proteasomes are large multimeric self-compartmentalizing proteases, involved in the clearance of misfolded proteins; Region: proteasome_protease_HslV; cd01906
326424006036	active site
326424006037	proteasome, alpha subunit, bacterial type; Region: 20S_bact_alpha; TIGR03691
326424006038	proteasome_protease_HslV. This group contains the eukaryotic proteosome alpha and beta subunits and the prokaryotic protease hslV subunit. Proteasomes are large multimeric self-compartmentalizing proteases, involved in the clearance of misfolded proteins; Region: proteasome_protease_HslV; cd01906
326424006039	active site
326424006040	Dienelactone hydrolase family; Region: DLH; pfam01738
326424006041	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
326424006042	Pup-ligase protein; Region: Pup_ligase; cl15463
326424006043	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; cl11587
326424006044	Predicted transcriptional regulator [Transcription]; Region: COG2378
326424006045	WYL domain; Region: WYL; cl14852
326424006046	Predicted transcriptional regulator [Transcription]; Region: COG2378
326424006047	WYL domain; Region: WYL; cl14852
326424006048	mttA/Hcf106 family; Region: MttA_Hcf106; cl00788
326424006049	Sec-independent protein translocase protein (TatC); Region: TatC; cl00521
326424006050	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
326424006051	ATP binding site [chemical binding]; other site
326424006052	putative Mg++ binding site [ion binding]; other site
326424006053	Superfamily II RNA helicase [DNA replication, recombination, and repair]; Region: COG4581
326424006054	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
326424006055	nucleotide binding region [chemical binding]; other site
326424006056	ATP-binding site [chemical binding]; other site
326424006057	DSHCT (NUC185) domain; Region: DSHCT; pfam08148
326424006058	CobD/Cbib protein; Region: CobD_Cbib; cl00561
326424006059	cobyric acid synthase; Provisional; Region: PRK00784
326424006060	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
326424006061	Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750
326424006062	catalytic triad [active]
326424006063	short chain dehydrogenase; Provisional; Region: PRK06197
326424006064	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
326424006065	NAD(P) binding site [chemical binding]; other site
326424006066	active site
326424006067	Acyl-CoA dehydrogenase (ACAD) 10 and 11, N-terminal domain, and similar proteins. This subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: ACAD10_11_like; cd05154
326424006068	Phosphotransferase enzyme family; Region: APH; pfam01636
326424006069	putative active site [active]
326424006070	putative substrate binding site [chemical binding]; other site
326424006071	ATP binding site [chemical binding]; other site
326424006072	4Fe-4S single cluster domain; Region: Fer4_15; pfam13459
326424006073	Protein of unknown function (DUF1271); Region: DUF1271; cl01443
326424006074	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; cl12078
326424006075	3-ketoacyl-(acyl-carrier-protein) reductase; Reviewed; Region: PRK12826
326424006076	classical (c) SDRs; Region: SDR_c; cd05233
326424006077	NAD(P) binding site [chemical binding]; other site
326424006078	active site
326424006079	NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961
326424006080	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
326424006081	NAD(P) binding site [chemical binding]; other site
326424006082	catalytic residues [active]
326424006083	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
326424006084	Helix-turn-helix domains; Region: HTH; cl00088
326424006085	Uncharacterized protein related to deoxyribodipyrimidine photolyase [General function prediction only]; Region: COG3046
326424006086	Deoxyribodipyrimidine photo-lyase-related protein; Region: DPRP; pfam04244
326424006087	FAD binding domain of DNA photolyase; Region: FAD_binding_7; pfam03441
326424006088	DNA-binding transcriptional regulator CynR; Provisional; Region: PRK11242
326424006089	Helix-turn-helix domains; Region: HTH; cl00088
326424006090	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_3; cd08436
326424006091	putative dimerization interface [polypeptide binding]; other site
326424006092	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
326424006093	putative substrate translocation pore; other site
326424006094	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
326424006095	S-adenosylmethionine binding site [chemical binding]; other site
326424006096	Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419
326424006097	This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784
326424006098	active site
326424006099	TDP-binding site; other site
326424006100	glycosyltransferase, MGT family; Region: MGT; TIGR01426
326424006101	acceptor substrate-binding pocket; other site
326424006102	homodimer interface [polypeptide binding]; other site
326424006103	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
326424006104	classical (c) SDRs; Region: SDR_c; cd05233
326424006105	NAD(P) binding site [chemical binding]; other site
326424006106	active site
326424006107	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
326424006108	motif II; other site
326424006109	ABC transporter transmembrane region; Region: ABC_membrane; cl00549
326424006110	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
326424006111	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
326424006112	Walker A/P-loop; other site
326424006113	ATP binding site [chemical binding]; other site
326424006114	Q-loop/lid; other site
326424006115	ABC transporter signature motif; other site
326424006116	Walker B; other site
326424006117	D-loop; other site
326424006118	H-loop/switch region; other site
326424006119	Glycosyl transferase 4-like domain; Region: Glyco_trans_4_4; cl15759
326424006120	This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784
326424006121	TDP-binding site; other site
326424006122	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
326424006123	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
326424006124	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
326424006125	polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833
326424006126	active site
326424006127	Acyl transferase domain; Region: Acyl_transf_1; cl08282
326424006128	Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826
326424006129	putative enoyl-[acyl-carrier-protein] reductase II; Region: enACPred_II; TIGR03151
326424006130	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl09108
326424006131	phosphate binding site [ion binding]; other site
326424006132	polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833
326424006133	beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150
326424006134	active site
326424006135	Acyl transferase domain; Region: Acyl_transf_1; cl08282
326424006136	Acyl transferase domain; Region: Acyl_transf_1; cl08282
326424006137	polyketide-type polyunsaturated fatty acid synthase PfaA; Region: omega_3_PfaA; TIGR02813
326424006138	ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953
326424006139	putative NADP binding site [chemical binding]; other site
326424006140	active site
326424006141	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
326424006142	NAD(P) binding site [chemical binding]; other site
326424006143	active site
326424006144	Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109
326424006145	Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109
326424006146	Helix-turn-helix domains; Region: HTH; cl00088
326424006147	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
326424006148	N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357
326424006149	Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431
326424006150	catalytic triad [active]
326424006151	conserved cis-peptide bond; other site
326424006152	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
326424006153	active site
326424006154	Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338
326424006155	catalytic residues [active]
326424006156	catalytic nucleophile [active]
326424006157	Recombinase; Region: Recombinase; pfam07508
326424006158	Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408
326424006159	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
326424006160	Catalytic domain of Protein Kinases; Region: PKc; cd00180
326424006161	active site
326424006162	ATP binding site [chemical binding]; other site
326424006163	substrate binding site [chemical binding]; other site
326424006164	activation loop (A-loop); other site
326424006165	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567
326424006166	structural tetrad; other site
326424006167	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
326424006168	S-adenosylmethionine binding site [chemical binding]; other site
326424006169	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
326424006170	Radical SAM superfamily; Region: Radical_SAM; pfam04055
326424006171	FeS/SAM binding site; other site
326424006172	Predicted metal-dependent phosphoesterases (PHP family) [General function prediction only]; Region: COG0613
326424006173	S-adenosyl methyltransferase; Region: Methyltransf_19; pfam04672
326424006174	Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cl02788
326424006175	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
326424006176	active site
326424006177	phosphorylation site [posttranslational modification]
326424006178	intermolecular recognition site; other site
326424006179	dimerization interface [polypeptide binding]; other site
326424006180	Domain of unknown function (DUF222); Region: DUF222; pfam02720
326424006181	Helix-Turn-Helix DNA binding domain of putative transcription regulators from the MerR superfamily; Region: HTH_MerR-like_sg3; cd01282
326424006182	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
326424006183	DNA binding residues [nucleotide binding]
326424006184	putative dimer interface [polypeptide binding]; other site
326424006185	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
326424006186	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
326424006187	active site
326424006188	catalytic tetrad [active]
326424006189	S-adenosyl methyltransferase; Region: Methyltransf_19; pfam04672
326424006190	3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084
326424006191	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
326424006192	type VII secretion protein EccCa; Region: T7SS_EccC_a; TIGR03924
326424006193	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
326424006194	type VII secretion protein EccCb; Region: T7SS_EccC_b; TIGR03925
326424006195	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
326424006196	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
326424006197	Ubiquitin-like proteins; Region: UBQ; cl00155
326424006198	Ubiquitin-like proteins; Region: UBQ; cl00155
326424006199	Protein of unknown function (DUF690); Region: DUF690; cl04939
326424006200	Proteins of 100 residues with WXG; Region: WXG100; cl02005
326424006201	Right handed beta helix region; Region: Beta_helix; pfam13229
326424006202	Right handed beta helix region; Region: Beta_helix; pfam13229
326424006203	stage V sporulation protein K; Region: spore_V_K; TIGR02881
326424006204	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
326424006205	Walker A motif; other site
326424006206	ATP binding site [chemical binding]; other site
326424006207	Walker B motif; other site
326424006208	arginine finger; other site
326424006209	stage V sporulation protein K; Region: spore_V_K; TIGR02881
326424006210	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
326424006211	Walker A motif; other site
326424006212	ATP binding site [chemical binding]; other site
326424006213	Walker B motif; other site
326424006214	arginine finger; other site
326424006215	Molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: DnaK; COG0443
326424006216	Ricin-type beta-trefoil lectin domain; Region: Ricin_B_lectin; pfam00652
326424006217	Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161
326424006218	putative sugar binding sites [chemical binding]; other site
326424006219	Q-X-W motif; other site
326424006220	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
326424006221	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761
326424006222	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
326424006223	The BcrA subfamily represents ABC transporters involved in peptide antibiotic resistance.  Bacitracin is a dodecapeptide antibiotic produced by B. licheniformis and B. subtilis.  The synthesis of bacitracin is non-ribosomally catalyzed by a multienzyme...; Region: ABC_BcrA_bacitracin_resist; cd03268
326424006224	Walker A/P-loop; other site
326424006225	ATP binding site [chemical binding]; other site
326424006226	Q-loop/lid; other site
326424006227	ABC transporter signature motif; other site
326424006228	Walker B; other site
326424006229	D-loop; other site
326424006230	H-loop/switch region; other site
326424006231	ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730
326424006232	Histidine kinase; Region: HisKA_3; pfam07730
326424006233	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075
326424006234	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
326424006235	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
326424006236	active site
326424006237	phosphorylation site [posttranslational modification]
326424006238	intermolecular recognition site; other site
326424006239	dimerization interface [polypeptide binding]; other site
326424006240	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
326424006241	DNA binding residues [nucleotide binding]
326424006242	dimerization interface [polypeptide binding]; other site
326424006243	S-adenosyl methyltransferase; Region: Methyltransf_19; pfam04672
326424006244	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
326424006245	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
326424006246	active site
326424006247	phosphorylation site [posttranslational modification]
326424006248	intermolecular recognition site; other site
326424006249	dimerization interface [polypeptide binding]; other site
326424006250	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
326424006251	DNA binding residues [nucleotide binding]
326424006252	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585
326424006253	Histidine kinase; Region: HisKA_3; pfam07730
326424006254	polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833
326424006255	Beta-ketoacyl synthase; Region: PKS_KS; smart00825
326424006256	active site
326424006257	malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128
326424006258	Acyl transferase domain; Region: Acyl_transf_1; cl08282
326424006259	Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826
326424006260	enoyl reductase of polyketide synthase; Region: enoyl_red; cd05195
326424006261	Enoylreductase; Region: PKS_ER; smart00829
326424006262	NAD(P) binding site [chemical binding]; other site
326424006263	beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 2, complex (x); Region: KR_2_FAS_SDR_x; cd08955
326424006264	putative NADP binding site [chemical binding]; other site
326424006265	active site
326424006266	Phosphopantetheine attachment site; Region: PP-binding; cl09936
326424006267	3-oxoacyl-(acyl-carrier-protein) synthase [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: FabB; COG0304
326424006268	Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938
326424006269	active site
326424006270	Response regulator of citrate/malate metabolism [Transcription / Signal transduction mechanisms]; Region: CitB; COG4565
326424006271	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
326424006272	active site
326424006273	phosphorylation site [posttranslational modification]
326424006274	intermolecular recognition site; other site
326424006275	dimerization interface [polypeptide binding]; other site
326424006276	Helix-turn-helix domains; Region: HTH; cl00088
326424006277	Signal transduction histidine kinase regulating citrate/malate metabolism [Signal transduction mechanisms]; Region: CitA; COG3290
326424006278	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
326424006279	ATP binding site [chemical binding]; other site
326424006280	G-X-G motif; other site
326424006281	Periplasmic binding protein; Region: Peripla_BP_6; pfam13458
326424006282	Type I periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type active transport systems that are predicted to be involved in transport of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_7; cd06341
326424006283	putative ligand binding site [chemical binding]; other site
326424006284	Protein of unknown function (DUF1271); Region: DUF1271; cl01443
326424006285	4Fe-4S single cluster domain; Region: Fer4_15; pfam13459
326424006286	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; cl12078
326424006287	Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113
326424006288	Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531
326424006289	DNA-binding transcriptional regulator CynR; Provisional; Region: PRK11242
326424006290	Helix-turn-helix domains; Region: HTH; cl00088
326424006291	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
326424006292	dimerization interface [polypeptide binding]; other site
326424006293	This family contains NADPH-dependent flavin reductase and oxygen-insensitive nitroreductase. These enzymes are homodimeric flavoproteins that contain one FMN per monomer as a cofactor. Flavin reductase catalyzes the reduction of flavin by using NADPH as...; Region: NfsA_FRP; cd02146
326424006294	dimer interface [polypeptide binding]; other site
326424006295	FMN binding site [chemical binding]; other site
326424006296	NADPH bind site [chemical binding]; other site
326424006297	Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342
326424006298	catalytic residue [active]
326424006299	Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat2; cd03445
326424006300	acyl-CoA thioesterase II; Region: tesB; TIGR00189
326424006301	active site
326424006302	Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat1; cd03444
326424006303	catalytic triad [active]
326424006304	dimer interface [polypeptide binding]; other site
326424006305	S-adenosyl methyltransferase; Region: Methyltransf_19; pfam04672
326424006306	nif11-class peptide radical SAM maturase 3; Region: rSAM_nif11_3; TIGR04103
326424006307	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
326424006308	FeS/SAM binding site; other site
326424006309	Domain of unknown function (DUF4008); Region: DUF4008; cl14869
326424006310	Enterobacter aerogenes GpdQ and related proteins, metallophosphatase domain; Region: MPP_GpdQ; cd07402
326424006311	active site
326424006312	metal binding site [ion binding]; metal-binding site
326424006313	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
326424006314	hexamer interface [polypeptide binding]; other site
326424006315	Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr; Region: PTPc; cl00053
326424006316	Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr; Region: PTPc; cl00053
326424006317	Tyrosine phosphatase family C-terminal region; Region: Y_phosphatase3C; pfam13348
326424006318	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
326424006319	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
326424006320	YbaK-like.  The YbaK family of deacylase domains includes the INS amino acid-editing domain of  the bacterial class II prolyl tRNA synthetase (ProRS), and it's trans-acting homologs, YbaK, ProX, and PrdX.  The primary function of INS is to hydrolyze...; Region: YbaK_like; cd04332
326424006321	putative deacylase active site [active]
326424006322	LysE type translocator; Region: LysE; cl00565
326424006323	DNA-binding transcriptional activator of the SARP family [Signal transduction mechanisms]; Region: DnrI; COG3629
326424006324	Helix-turn-helix domains; Region: HTH; cl00088
326424006325	Predicted ATPase [General function prediction only]; Region: COG3899
326424006326	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
326424006327	Domain of unknown function (DUF4267); Region: DUF4267; pfam14087
326424006328	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
326424006329	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
326424006330	Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381
326424006331	Predicted dinucleotide-binding enzymes [General function prediction only]; Region: COG2085
326424006332	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
326424006333	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
326424006334	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
326424006335	active site
326424006336	catalytic tetrad [active]
326424006337	Gas vesicle synthesis protein GvpL/GvpF; Region: GvpL_GvpF; pfam06386
326424006338	Gas vesicle protein K; Region: GvpK; pfam05121
326424006339	Gas vesicle protein; Region: Gas_vesicle; cl02954
326424006340	Gas vesicle synthesis protein GvpL/GvpF; Region: GvpL_GvpF; pfam06386
326424006341	Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_8; cd07817
326424006342	putative hydrophobic ligand binding site [chemical binding]; other site
326424006343	Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814
326424006344	putative hydrophobic ligand binding site [chemical binding]; other site
326424006345	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
326424006346	dimerization interface [polypeptide binding]; other site
326424006347	putative DNA binding site [nucleotide binding]; other site
326424006348	putative Zn2+ binding site [ion binding]; other site
326424006349	Domain of unknown function (DUF222); Region: DUF222; pfam02720
326424006350	Domain of unknown function (DUF222); Region: DUF222; pfam02720
326424006351	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
326424006352	active site
326424006353	DoxX; Region: DoxX; cl00976
326424006354	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
326424006355	Helix-turn-helix domains; Region: HTH; cl00088
326424006356	Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469
326424006357	[2Fe-2S] cluster binding site [ion binding]; other site
326424006358	C-terminal catalytic domain of Pseudomonas fluorescens MupW and related aromatic ring hydroxylating dioxygenases; Region: RHO_alpha_C_MupW-like; cd08882
326424006359	putative alpha subunit interface [polypeptide binding]; other site
326424006360	putative active site [active]
326424006361	putative substrate binding site [chemical binding]; other site
326424006362	Fe binding site [ion binding]; other site
326424006363	CDP-6-deoxy-delta-3,4-glucoseen reductase; Validated; Region: PRK07609
326424006364	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cl00159
326424006365	hypothetical protein; Validated; Region: PRK07121
326424006366	pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_y; TIGR03182
326424006367	Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000
326424006368	tetramer interface [polypeptide binding]; other site
326424006369	TPP-binding site [chemical binding]; other site
326424006370	heterodimer interface [polypeptide binding]; other site
326424006371	phosphorylation loop region [posttranslational modification]
326424006372	Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022
326424006373	Pyrimidine (PYR) binding domain of thiamine pyrophosphate (TPP)-dependent enzymes; Region: TPP_enzyme_PYR; cl11410
326424006374	PYR/PP interface [polypeptide binding]; other site
326424006375	dimer interface [polypeptide binding]; other site
326424006376	TPP binding site [chemical binding]; other site
326424006377	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
326424006378	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
326424006379	E3 interaction surface; other site
326424006380	lipoyl attachment site [posttranslational modification]; other site
326424006381	3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565
326424006382	classical (c) SDRs; Region: SDR_c; cd05233
326424006383	NAD(P) binding site [chemical binding]; other site
326424006384	active site
326424006385	cytokinin dehydrogenase; Region: PLN02441
326424006386	DNA-binding transcriptional activator of the SARP family [Signal transduction mechanisms]; Region: DnrI; COG3629
326424006387	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
326424006388	DNA binding site [nucleotide binding]
326424006389	Predicted ATPase [General function prediction only]; Region: COG3899
326424006390	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
326424006391	START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643
326424006392	hydrophobic ligand binding site; other site
326424006393	2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiH; COG0654
326424006394	Retinal pigment epithelial membrane protein; Region: RPE65; cl10080
326424006395	3-(3-hydroxyphenyl)propionate hydroxylase; Validated; Region: mhpA; PRK06183
326424006396	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
326424006397	hypothetical protein; Provisional; Region: PRK06194
326424006398	classical (c) SDRs; Region: SDR_c; cd05233
326424006399	NAD(P) binding site [chemical binding]; other site
326424006400	active site
326424006401	The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509
326424006402	Helix-turn-helix domains; Region: HTH; cl00088
326424006403	Acyl-CoA dehydrogenase (ACAD) 10 and 11, N-terminal domain, and similar proteins. This subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: ACAD10_11_like; cd05154
326424006404	putative active site [active]
326424006405	putative substrate binding site [chemical binding]; other site
326424006406	ATP binding site [chemical binding]; other site
326424006407	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
326424006408	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
326424006409	active site
326424006410	probable F420-dependent oxidoreductase, Rv2161c family; Region: F420_Rv2161c; TIGR03619
326424006411	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
326424006412	3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830
326424006413	classical (c) SDRs; Region: SDR_c; cd05233
326424006414	NAD(P) binding site [chemical binding]; other site
326424006415	active site
326424006416	Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109
326424006417	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; cl12078
326424006418	Periplasmic binding protein; Region: Peripla_BP_6; pfam13458
326424006419	Type I periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type active transport systems that are predicted to be involved in transport of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_7; cd06341
326424006420	putative ligand binding site [chemical binding]; other site
326424006421	Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318
326424006422	AMP-binding enzyme; Region: AMP-binding; cl15778
326424006423	DNA-binding transcriptional activator XapR; Provisional; Region: PRK09986
326424006424	Helix-turn-helix domains; Region: HTH; cl00088
326424006425	The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414
326424006426	dimerization interface [polypeptide binding]; other site
326424006427	substrate binding pocket [chemical binding]; other site
326424006428	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
326424006429	Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233
326424006430	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
326424006431	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
326424006432	D-alanine--D-alanine ligase; Reviewed; Region: ddl; PRK01372
326424006433	D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820
326424006434	ATP-grasp domain; Region: ATP-grasp_4; cl03087
326424006435	Aspartate/tyrosine/aromatic aminotransferase [Amino acid transport and metabolism]; Region: COG0436
326424006436	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
326424006437	pyridoxal 5'-phosphate binding site [chemical binding]; other site
326424006438	homodimer interface [polypeptide binding]; other site
326424006439	catalytic residue [active]
326424006440	Probable transposase; Region: OrfB_IS605; pfam01385
326424006441	Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282
326424006442	Transposase domain (DUF772); Region: DUF772; cl15789
326424006443	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
326424006444	Transposase domain (DUF772); Region: DUF772; cl15789
326424006445	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
326424006446	substrate binding pocket [chemical binding]; other site
326424006447	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
326424006448	membrane-bound complex binding site; other site
326424006449	hinge residues; other site
326424006450	Transposase domain (DUF772); Region: DUF772; cl15789
326424006451	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
326424006452	Transposase domain (DUF772); Region: DUF772; cl15789
326424006453	Predicted nucleic-acid-binding protein containing a Zn-ribbon [General function prediction only]; Region: COG1545
326424006454	Rubredoxin-like zinc ribbon domain (DUF35_N); Region: DUF35_N; pfam12172
326424006455	Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2  has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829
326424006456	lipid-transfer protein; Provisional; Region: PRK07855
326424006457	active site
326424006458	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557
326424006459	classical (c) SDRs; Region: SDR_c; cd05233
326424006460	NAD(P) binding site [chemical binding]; other site
326424006461	active site
326424006462	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
326424006463	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
326424006464	long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187
326424006465	AMP-binding enzyme; Region: AMP-binding; cl15778
326424006466	AMP-binding enzyme; Region: AMP-binding; cl15778
326424006467	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
326424006468	Helix-turn-helix domains; Region: HTH; cl00088
326424006469	Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cl00454
326424006470	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411
326424006471	The Mj1267/LivG ABC transporter subfamily is involved in the transport of the hydrophobic amino acids leucine, isoleucine and valine.  MJ1267 is a branched-chain amino acid transporter with 29% similarity to both the LivF and LivG components of the E; Region: ABC_Mj1267_LivG_branched; cd03219
326424006472	Walker A/P-loop; other site
326424006473	ATP binding site [chemical binding]; other site
326424006474	Q-loop/lid; other site
326424006475	ABC transporter signature motif; other site
326424006476	Walker B; other site
326424006477	D-loop; other site
326424006478	H-loop/switch region; other site
326424006479	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410
326424006480	LivF (TM1139) is part of the LIV-I bacterial ABC-type two-component transport system that imports neutral, branched-chain amino acids.  The  E. coli branched-chain amino acid transporter comprises a heterodimer of ABC transporters (LivF and LivG), a...; Region: ABC_TM1139_LivF_branched; cd03224
326424006481	Walker A/P-loop; other site
326424006482	ATP binding site [chemical binding]; other site
326424006483	Q-loop/lid; other site
326424006484	ABC transporter signature motif; other site
326424006485	Walker B; other site
326424006486	D-loop; other site
326424006487	H-loop/switch region; other site
326424006488	acetyl-CoA acetyltransferase; Validated; Region: PRK08242
326424006489	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
326424006490	dimer interface [polypeptide binding]; other site
326424006491	active site
326424006492	Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804
326424006493	CoA-transferase family III; Region: CoA_transf_3; pfam02515
326424006494	Acyl-CoA dehydrogenase (ACAD) 10 and 11, N-terminal domain, and similar proteins. This subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: ACAD10_11_like; cd05154
326424006495	putative active site [active]
326424006496	ATP binding site [chemical binding]; other site
326424006497	putative substrate binding site [chemical binding]; other site
326424006498	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
326424006499	Type I periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type active transport systems that are predicted to be involved in transport of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_7; cd06341
326424006500	putative ligand binding site [chemical binding]; other site
326424006501	Helix-turn-helix domains; Region: HTH; cl00088
326424006502	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
326424006503	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
326424006504	S-adenosylmethionine binding site [chemical binding]; other site
326424006505	Phenylacetic acid catabolic protein; Region: PaaA_PaaC; cl01346
326424006506	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
326424006507	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
326424006508	active site
326424006509	probable F420-dependent oxidoreductase, MSMEG_2249 family; Region: F420_MSMEG_2249; TIGR03857
326424006510	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
326424006511	Coenzyme F390 synthetase [Coenzyme metabolism]; Region: PaaK; COG1541
326424006512	AMP-binding enzyme; Region: AMP-binding; cl15778
326424006513	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
326424006514	enoyl-CoA hydratase; Provisional; Region: PRK06688
326424006515	substrate binding site [chemical binding]; other site
326424006516	oxyanion hole (OAH) forming residues; other site
326424006517	trimer interface [polypeptide binding]; other site
326424006518	The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509
326424006519	active site 2 [active]
326424006520	active site 1 [active]
326424006521	The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509
326424006522	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
326424006523	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
326424006524	NAD(P) binding site [chemical binding]; other site
326424006525	active site
326424006526	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
326424006527	NAD(P) binding site [chemical binding]; other site
326424006528	active site
326424006529	FkbR2 is a Streptomyces hygroscopicus protein with a hot dog fold that belongs to a conserved family of proteins found in prokaryotes and archaea but not in eukaryotes. FkbR2  has sequence similarity to (R)-specific enoyl-CoA hydratase, the peroxisomal...; Region: FkbR2; cd03451
326424006530	putative active site [active]
326424006531	putative catalytic site [active]
326424006532	Pyruvate kinase (PK):  Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl09155
326424006533	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
326424006534	hydroxyglutarate oxidase; Provisional; Region: PRK11728
326424006535	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
326424006536	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
326424006537	NAD(P) binding site [chemical binding]; other site
326424006538	active site
326424006539	NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961
326424006540	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
326424006541	NAD(P) binding site [chemical binding]; other site
326424006542	catalytic residues [active]
326424006543	Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454
326424006544	Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872
326424006545	active site
326424006546	NAD binding site [chemical binding]; other site
326424006547	metal binding site [ion binding]; metal-binding site
326424006548	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
326424006549	probable F420-dependent oxidoreductase, Rv2161c family; Region: F420_Rv2161c; TIGR03619
326424006550	Tandem repeat subunit of reelin and related proteins; Region: Reelin_subrepeat_like; cl15240
326424006551	Transcriptional regulators [Transcription]; Region: FadR; COG2186
326424006552	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
326424006553	DNA-binding site [nucleotide binding]; DNA binding site
326424006554	FCD domain; Region: FCD; cl11656
326424006555	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410
326424006556	LivF (TM1139) is part of the LIV-I bacterial ABC-type two-component transport system that imports neutral, branched-chain amino acids.  The  E. coli branched-chain amino acid transporter comprises a heterodimer of ABC transporters (LivF and LivG), a...; Region: ABC_TM1139_LivF_branched; cd03224
326424006557	Walker A/P-loop; other site
326424006558	ATP binding site [chemical binding]; other site
326424006559	Q-loop/lid; other site
326424006560	ABC transporter signature motif; other site
326424006561	Walker B; other site
326424006562	D-loop; other site
326424006563	H-loop/switch region; other site
326424006564	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
326424006565	TM-ABC transporter signature motif; other site
326424006566	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
326424006567	TM-ABC transporter signature motif; other site
326424006568	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411
326424006569	The Mj1267/LivG ABC transporter subfamily is involved in the transport of the hydrophobic amino acids leucine, isoleucine and valine.  MJ1267 is a branched-chain amino acid transporter with 29% similarity to both the LivF and LivG components of the E; Region: ABC_Mj1267_LivG_branched; cd03219
326424006570	Walker A/P-loop; other site
326424006571	ATP binding site [chemical binding]; other site
326424006572	Q-loop/lid; other site
326424006573	ABC transporter signature motif; other site
326424006574	Walker B; other site
326424006575	D-loop; other site
326424006576	H-loop/switch region; other site
326424006577	Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804
326424006578	CoA-transferase family III; Region: CoA_transf_3; pfam02515
326424006579	Acetoacetate decarboxylase (ADC); Region: ADC; cl01919
326424006580	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
326424006581	Periplasmic binding protein; Region: Peripla_BP_6; pfam13458
326424006582	Type I periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type active transport systems that are predicted to be involved in transport of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_7; cd06341
326424006583	putative ligand binding site [chemical binding]; other site
326424006584	pimeloyl-CoA dehydrogenase, large subunit; Region: pimC_large; TIGR03204
326424006585	Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771
326424006586	Acyl-CoA dehydrogenase, middle domain; Region: Acyl-CoA_dh_M; pfam02770
326424006587	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
326424006588	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
326424006589	Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771
326424006590	Acyl-CoA dehydrogenase; Region: ACAD; cd00567
326424006591	active site
326424006592	Periplasmic binding protein; Region: Peripla_BP_6; pfam13458
326424006593	Periplasmic binding domain of ATP-binding cassette transporter-like systems that belong to the type I periplasmic binding fold protein superfamily; Region: PBP1_ABC_transporter_LIVBP_like; cd06268
326424006594	ligand binding site [chemical binding]; other site
326424006595	enoyl-CoA hydratase; Provisional; Region: PRK06688
326424006596	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
326424006597	substrate binding site [chemical binding]; other site
326424006598	oxyanion hole (OAH) forming residues; other site
326424006599	trimer interface [polypeptide binding]; other site
326424006600	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
326424006601	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
326424006602	NAD(P) binding site [chemical binding]; other site
326424006603	active site
326424006604	Domain of unknown function (DUF222); Region: DUF222; pfam02720
326424006605	Domain of unknown function (DUF222); Region: DUF222; pfam02720
326424006606	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
326424006607	active site
326424006608	Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431
326424006609	catalytic triad [active]
326424006610	conserved cis-peptide bond; other site
326424006611	cyclohexanecarboxylate-CoA ligase; Reviewed; Region: PRK13295
326424006612	AMP-binding enzyme; Region: AMP-binding; cl15778
326424006613	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
326424006614	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
326424006615	active site
326424006616	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
326424006617	active site
326424006618	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
326424006619	Acyl-CoA dehydrogenase; Region: ACAD; cd00567
326424006620	active site
326424006621	coenzyme F420-dependent oxidoreductase, NP1902A family; Region: F420_NP1902A; TIGR04024
326424006622	N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097
326424006623	SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339
326424006624	SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339
326424006625	The band 7 domain of flotillin (reggie) like proteins. This group contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin.  Many of these band 7 domain-containing proteins are lipid raft-associated.  Individual proteins of this...; Region: Band_7; cl02525
326424006626	3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084
326424006627	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
326424006628	3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084
326424006629	Helix-turn-helix domains; Region: HTH; cl00088
326424006630	Helix-turn-helix domains; Region: HTH; cl00088
326424006631	Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799
326424006632	Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl15772
326424006633	Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl15772
326424006634	Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770
326424006635	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
326424006636	ATP-grasp domain; Region: ATP-grasp_4; cl03087
326424006637	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; cl08365
326424006638	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
326424006639	carboxyltransferase (CT) interaction site; other site
326424006640	biotinylation site [posttranslational modification]; other site
326424006641	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
326424006642	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
326424006643	active site
326424006644	Uncharacterized membrane-anchored protein conserved in bacteria [Function unknown]; Region: COG4705
326424006645	Repeat of Unknown Function (DUF347); Region: DUF347; pfam03988
326424006646	Repeat of Unknown Function (DUF347); Region: DUF347; pfam03988
326424006647	Repeat of Unknown Function (DUF347); Region: DUF347; pfam03988
326424006648	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
326424006649	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
326424006650	active site
326424006651	phosphorylation site [posttranslational modification]
326424006652	intermolecular recognition site; other site
326424006653	dimerization interface [polypeptide binding]; other site
326424006654	Helix-turn-helix domains; Region: HTH; cl00088
326424006655	DNA binding site [nucleotide binding]
326424006656	membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082
326424006657	membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082
326424006658	Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431
326424006659	catalytic triad [active]
326424006660	conserved cis-peptide bond; other site
326424006661	Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753
326424006662	Clade 3 of the heme-binding enzyme catalase; Region: catalase_clade_3; cd08156
326424006663	tetramer interface [polypeptide binding]; other site
326424006664	heme binding pocket [chemical binding]; other site
326424006665	NADPH binding site [chemical binding]; other site
326424006666	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153
326424006667	metal binding site 2 [ion binding]; metal-binding site
326424006668	putative DNA binding helix; other site
326424006669	metal binding site 1 [ion binding]; metal-binding site
326424006670	dimer interface [polypeptide binding]; other site
326424006671	structural Zn2+ binding site [ion binding]; other site
326424006672	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
326424006673	phenylpropionate dioxygenase ferredoxin reductase subunit; Provisional; Region: PRK09754
326424006674	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
326424006675	S-adenosyl methyltransferase; Region: Methyltransf_19; pfam04672
326424006676	Glycosyl hydrolase family 26; Region: Glyco_hydro_26; cl09200
326424006677	GlcNAc-PI de-N-acetylase; Region: PIG-L; cl00929
326424006678	Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031
326424006679	Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342
326424006680	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
326424006681	catalytic residue [active]
326424006682	Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; cl00986
326424006683	DinB superfamily; Region: DinB_2; pfam12867
326424006684	AMP-binding enzyme; Region: AMP-binding; cl15778
326424006685	NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961
326424006686	NAD(P) binding site [chemical binding]; other site
326424006687	catalytic residues [active]
326424006688	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
326424006689	CoenzymeA binding site [chemical binding]; other site
326424006690	subunit interaction site [polypeptide binding]; other site
326424006691	PHB binding site; other site
326424006692	AMP-binding domain protein; Validated; Region: PRK08315
326424006693	long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07768
326424006694	AMP-binding enzyme; Region: AMP-binding; cl15778
326424006695	Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657
326424006696	dinuclear metal binding motif [ion binding]; other site
326424006697	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
326424006698	PHB binding site; other site
326424006699	CoenzymeA binding site [chemical binding]; other site
326424006700	subunit interaction site [polypeptide binding]; other site
326424006701	Phosphopantetheine attachment site; Region: PP-binding; cl09936
326424006702	Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane]; Region: Cfa; COG2230
326424006703	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
326424006704	S-adenosylmethionine binding site [chemical binding]; other site
326424006705	Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cl00264
326424006706	dinuclear metal binding motif [ion binding]; other site
326424006707	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; cl12078
326424006708	DNA-binding transcriptional regulator HcaR; Provisional; Region: PRK09906
326424006709	Helix-turn-helix domains; Region: HTH; cl00088
326424006710	The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414
326424006711	dimerization interface [polypeptide binding]; other site
326424006712	substrate binding pocket [chemical binding]; other site
326424006713	AMP-binding enzyme; Region: AMP-binding; cl15778
326424006714	Dehydrogenases (flavoproteins) [Energy production and conversion]; Region: FixC; COG0644
326424006715	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
326424006716	Members of the SGNH-hydrolase superfamily, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_like_1; cd01832
326424006717	active site
326424006718	catalytic triad [active]
326424006719	oxyanion hole [active]
326424006720	polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833
326424006721	active site
326424006722	malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128
326424006723	Acyl transferase domain; Region: Acyl_transf_1; cl08282
326424006724	Phosphopantetheine attachment site; Region: PP-binding; cl09936
326424006725	Phosphopantetheine attachment site; Region: PP-binding; cl09936
326424006726	Phosphopantetheine attachment site; Region: PP-binding; cl09936
326424006727	ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953
326424006728	putative NADP binding site [chemical binding]; other site
326424006729	active site
326424006730	Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826
326424006731	The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509
326424006732	FabA, beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase: Bacterial protein of the type II, fatty acid synthase system that binds ACP and catalyzes both dehydration and isomerization reactions, apparently in the same active site. The FabA...; Region: FabA; cd01287
326424006733	active site 1 [active]
326424006734	dimer interface [polypeptide binding]; other site
326424006735	active site 2 [active]
326424006736	2-Nitropropane dioxygenase (NPD)-like domain, associated with the (acyl-carrier-protein) S-malonyltransferase  FabD. NPD is part of the nitroalkaneoxidizing enzyme family, that catalyzes oxidative denitrification of nitroalkanes to their corresponding...; Region: NPD_FabD; cd04742
326424006737	FMN binding site [chemical binding]; other site
326424006738	Dioxygenases related to 2-nitropropane dioxygenase [General function prediction only]; Region: COG2070
326424006739	substrate binding site [chemical binding]; other site
326424006740	putative catalytic residue [active]
326424006741	acetyl-CoA carboxylase, carboxyl transferase, beta subunit; Region: accD; TIGR00515
326424006742	Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl15772
326424006743	Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl15772
326424006744	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
326424006745	carboxyltransferase (CT) interaction site; other site
326424006746	biotinylation site [posttranslational modification]; other site
326424006747	acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591
326424006748	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
326424006749	ATP-grasp domain; Region: ATP-grasp_4; cl03087
326424006750	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; cl08365
326424006751	Domain of unknown function (DUF222); Region: DUF222; pfam02720
326424006752	Domain of unknown function (DUF222); Region: DUF222; pfam02720
326424006753	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
326424006754	active site
326424006755	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
326424006756	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587
326424006757	active site
326424006758	metal binding site [ion binding]; metal-binding site
326424006759	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
326424006760	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
326424006761	dimer interface [polypeptide binding]; other site
326424006762	conserved gate region; other site
326424006763	putative PBP binding loops; other site
326424006764	ABC-ATPase subunit interface; other site
326424006765	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427
326424006766	Enterobacter aerogenes GpdQ and related proteins, metallophosphatase domain; Region: MPP_GpdQ; cd07402
326424006767	active site
326424006768	metal binding site [ion binding]; metal-binding site
326424006769	hexamer interface [polypeptide binding]; other site
326424006770	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
326424006771	Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416
326424006772	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
326424006773	glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650
326424006774	The N-terminal ATPase domain of the maltose transporter, MalK.  ATP binding cassette (ABC) proteins function from bacteria to human, mediating the translocation of substances into and out of cells or organelles.  ABC transporters contain two...; Region: ABC_MalK_N; cd03301
326424006775	Walker A/P-loop; other site
326424006776	ATP binding site [chemical binding]; other site
326424006777	Q-loop/lid; other site
326424006778	ABC transporter signature motif; other site
326424006779	Walker B; other site
326424006780	D-loop; other site
326424006781	H-loop/switch region; other site
326424006782	TOBE domain; Region: TOBE_2; cl01440
326424006783	Predicted alpha/beta hydrolase [General function prediction only]; Region: COG4757
326424006784	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
326424006785	CoenzymeA binding site [chemical binding]; other site
326424006786	subunit interaction site [polypeptide binding]; other site
326424006787	PHB binding site; other site
326424006788	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
326424006789	Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771
326424006790	Acyl-CoA dehydrogenase; Region: ACAD; cd00567
326424006791	active site
326424006792	Phthalate dioxygenase reductase (PDR) is an FMN-dependent reductase that mediates electron transfer from NADH to FMN to an iron sulfur cluster. PDR has an an N-terminal  ferrredoxin reductase (FNR)-like NAD(H) binding domain and a C-terminal iron-sulfur; Region: PDR_like; cd06185
326424006793	phenylacetate-CoA oxygenase/reductase, PaaK subunit; Region: PA_CoA_Oxy5; TIGR02160
326424006794	FMN-binding pocket [chemical binding]; other site
326424006795	flavin binding motif; other site
326424006796	phosphate binding motif [ion binding]; other site
326424006797	beta-alpha-beta structure motif; other site
326424006798	NAD binding pocket [chemical binding]; other site
326424006799	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
326424006800	catalytic loop [active]
326424006801	iron binding site [ion binding]; other site
326424006802	Dehydrogenases (flavoproteins) [Energy production and conversion]; Region: FixC; COG0644
326424006803	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; cl12078
326424006804	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; cl12078
326424006805	Cytochrome P450; Region: p450; pfam00067
326424006806	Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692
326424006807	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; cl12078
326424006808	Domain of unknown function (DUF4098); Region: DUF4098; pfam13345
326424006809	Phosphoesterase family; Region: Phosphoesterase; cl15450
326424006810	translocation protein TolB; Provisional; Region: tolB; PRK02889
326424006811	Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109
326424006812	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
326424006813	Helix-turn-helix domains; Region: HTH; cl00088
326424006814	2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiH; COG0654
326424006815	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
326424006816	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
326424006817	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
326424006818	P-loop; other site
326424006819	Magnesium ion binding site [ion binding]; other site
326424006820	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
326424006821	Magnesium ion binding site [ion binding]; other site
326424006822	prephenate dehydratase; Provisional; Region: PRK11898
326424006823	Prephenate dehydratase; Region: PDT; pfam00800
326424006824	C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905
326424006825	putative L-Phe binding site [chemical binding]; other site
326424006826	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
326424006827	E3 interaction surface; other site
326424006828	lipoyl attachment site [posttranslational modification]; other site
326424006829	dihydrolipoamide acetyltransferase; Reviewed; Region: PRK11857
326424006830	e3 binding domain; Region: E3_binding; pfam02817
326424006831	2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; cl02008
326424006832	Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022
326424006833	Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036
326424006834	alpha subunit interface [polypeptide binding]; other site
326424006835	TPP binding site [chemical binding]; other site
326424006836	heterodimer interface [polypeptide binding]; other site
326424006837	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
326424006838	pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_x; TIGR03181
326424006839	Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000
326424006840	tetramer interface [polypeptide binding]; other site
326424006841	TPP-binding site [chemical binding]; other site
326424006842	heterodimer interface [polypeptide binding]; other site
326424006843	phosphorylation loop region [posttranslational modification]
326424006844	Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109
326424006845	Bacitracin resistance protein BacA; Region: BacA; cl00858
326424006846	SNARE associated Golgi protein; Region: SNARE_assoc; cl00429
326424006847	Uncharacterized membrane-anchored protein conserved in bacteria [Function unknown]; Region: COG4705
326424006848	Repeat of Unknown Function (DUF347); Region: DUF347; pfam03988
326424006849	Repeat of Unknown Function (DUF347); Region: DUF347; pfam03988
326424006850	Repeat of Unknown Function (DUF347); Region: DUF347; pfam03988
326424006851	Repeat of Unknown Function (DUF347); Region: DUF347; pfam03988
326424006852	Repeat of Unknown Function (DUF347); Region: DUF347; pfam03988
326424006853	Repeat of Unknown Function (DUF347); Region: DUF347; pfam03988
326424006854	Peptidase family M48; Region: Peptidase_M48; cl12018
326424006855	Domain of unknown function (DUF385); Region: DUF385; cl04387
326424006856	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
326424006857	Hemerythrin (Hr) is a non-heme diiron oxygen transport protein found in four marine invertebrate phyla including priapulida, brachiopoda, sipunculida, and annelida, as well as in protozoa. Myohemerythrin (Mhr), a hemerythrin homolog, is found in the...; Region: Hemerythrin; cl15774
326424006858	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
326424006859	NAD(P) binding site [chemical binding]; other site
326424006860	active site
326424006861	Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876
326424006862	Peptidase family M20/M25/M40; Region: Peptidase_M20; pfam01546
326424006863	metal binding site [ion binding]; metal-binding site
326424006864	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
326424006865	classical (c) SDRs; Region: SDR_c; cd05233
326424006866	NAD(P) binding site [chemical binding]; other site
326424006867	active site
326424006868	PAS fold; Region: PAS_4; pfam08448
326424006869	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
326424006870	metal binding site [ion binding]; metal-binding site
326424006871	active site
326424006872	I-site; other site
326424006873	Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cl15820
326424006874	Clp amino terminal domain; Region: Clp_N; pfam02861
326424006875	Clp amino terminal domain; Region: Clp_N; pfam02861
326424006876	Protein of unknown function (DUF972); Region: DUF972; pfam06156
326424006877	Protein of unknown function (DUF4232); Region: DUF4232; pfam14016
326424006878	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
326424006879	N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357
326424006880	Domain of unknown function (DUF4062); Region: DUF4062; pfam13271
326424006881	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
326424006882	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
326424006883	Major Facilitator Superfamily; Region: MFS_1; pfam07690
326424006884	putative substrate translocation pore; other site
326424006885	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
326424006886	NAD synthetase; Reviewed; Region: nadE; PRK02628
326424006887	Glutamine aminotransferase (GAT, glutaminase) domain of glutamine-dependent NAD synthetases (class 7 and 8 nitrilases); Region: GAT_Gln-NAD-synth; cd07570
326424006888	multimer interface [polypeptide binding]; other site
326424006889	active site
326424006890	catalytic triad [active]
326424006891	protein interface 1 [polypeptide binding]; other site
326424006892	NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553
326424006893	homodimer interface [polypeptide binding]; other site
326424006894	NAD binding pocket [chemical binding]; other site
326424006895	ATP binding pocket [chemical binding]; other site
326424006896	Mg binding site [ion binding]; other site
326424006897	active-site loop [active]
326424006898	pyruvate:ferredoxin (flavodoxin) oxidoreductase, homodimeric; Region: pyruv_ox_red; TIGR02176
326424006899	Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034
326424006900	dimer interface [polypeptide binding]; other site
326424006901	PYR/PP interface [polypeptide binding]; other site
326424006902	TPP binding site [chemical binding]; other site
326424006903	substrate binding site [chemical binding]; other site
326424006904	Pyruvate ferredoxin/flavodoxin oxidoreductase; Region: POR; cl00546
326424006905	Domain of unknown function; Region: EKR; cl11037
326424006906	4Fe-4S binding domain; Region: Fer4; cl02805
326424006907	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
326424006908	Thiamine pyrophosphate (TPP family), PFOR_PNO subfamily, TPP-binding module; composed of proteins similar to the single subunit pyruvate ferredoxin oxidoreductase (PFOR) of Desulfovibrio Africanus, present in bacteria and amitochondriate eukaryotes. This...; Region: TPP_PFOR_PNO; cd03377
326424006909	TPP-binding site [chemical binding]; other site
326424006910	dimer interface [polypeptide binding]; other site
326424006911	nitrobindin heme-binding domain; Region: nitrobindin; cd07828
326424006912	heme-binding site [chemical binding]; other site
326424006913	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
326424006914	SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2; cl00195
326424006915	Cation efflux family; Region: Cation_efflux; cl00316
326424006916	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
326424006917	Catalytic domain of Protein Kinases; Region: PKc; cd00180
326424006918	active site
326424006919	ATP binding site [chemical binding]; other site
326424006920	substrate binding site [chemical binding]; other site
326424006921	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
326424006922	substrate binding site [chemical binding]; other site
326424006923	activation loop (A-loop); other site
326424006924	activation loop (A-loop); other site
326424006925	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
326424006926	Helix-turn-helix domains; Region: HTH; cl00088
326424006927	drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711
326424006928	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
326424006929	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl09944
326424006930	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
326424006931	DNA binding residues [nucleotide binding]
326424006932	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585
326424006933	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585
326424006934	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075
326424006935	Molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: DnaK; COG0443
326424006936	FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121
326424006937	Helix-turn-helix domains; Region: HTH; cl00088
326424006938	drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711
326424006939	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
326424006940	putative substrate translocation pore; other site
326424006941	2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy; cl15773
326424006942	Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598
326424006943	magnesium/nickel/cobalt transporter CorA; Provisional; Region: PRK11085; cl00459
326424006944	probable extracellular repeat, HAF family; Region: HAF_rpt; TIGR02913
326424006945	probable extracellular repeat, HAF family; Region: HAF_rpt; TIGR02913
326424006946	probable extracellular repeat, HAF family; Region: HAF_rpt; TIGR02913
326424006947	NADPH-dependent FMN reductase; Region: FMN_red; cl00438
326424006948	Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175
326424006949	Clavaminic acid synthetase (CAS) -like;  CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cl00184
326424006950	substrate binding pocket [chemical binding]; other site
326424006951	active site
326424006952	iron coordination sites [ion binding]; other site
326424006953	SGNH_hydrolase subfamily, FeeA, FeeB and similar esterases/lipases. FeeA and FeeB are part of a biosynthetic gene cluster and may participate in the biosynthesis of long-chain N-acyltyrosines by providing saturated and unsaturated fatty acids, which it...; Region: FeeA_FeeB_like; cd01836
326424006954	active site
326424006955	catalytic triad [active]
326424006956	oxyanion hole [active]
326424006957	Predicted esterase [General function prediction only]; Region: COG0627
326424006958	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
326424006959	Sortases are cysteine transpeptidases, found in gram-positive bacteria, that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. They do so by catalyzing a transpeptidation reaction in which the surface protein substrate is...; Region: Sortase; cl09098
326424006960	catalytic site [active]
326424006961	Domain of unknown function (DUF4397); Region: DUF4397; pfam14344
326424006962	Flavin Reductases; Region: FlaRed; cl00801
326424006963	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
326424006964	active site
326424006965	ATP binding site [chemical binding]; other site
326424006966	substrate binding site [chemical binding]; other site
326424006967	activation loop (A-loop); other site
326424006968	Glutamate-cysteine ligase family 2(GCS2); Region: GCS2; cl00954
326424006969	Monomeric isocitrate dehydrogenase; Region: IDH; cl15383
326424006970	3-ketoacyl-(acyl-carrier-protein) reductase; Reviewed; Region: PRK12826
326424006971	classical (c) SDRs; Region: SDR_c; cd05233
326424006972	NAD(P) binding site [chemical binding]; other site
326424006973	active site
326424006974	probable F420-dependent oxidoreductase, Rv2161c family; Region: F420_Rv2161c; TIGR03619
326424006975	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
326424006976	Catalytic domain of Protein Kinases; Region: PKc; cd00180
326424006977	active site
326424006978	ATP binding site [chemical binding]; other site
326424006979	substrate binding site [chemical binding]; other site
326424006980	activation loop (A-loop); other site
326424006981	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200
326424006982	structural tetrad; other site
326424006983	superfamily containing globins and truncated hemoglobins; Region: globin_like; cl00280
326424006984	heme-binding site [chemical binding]; other site
326424006985	GAF domain; Region: GAF_2; pfam13185
326424006986	ANTAR domain; Region: ANTAR; cl04297
326424006987	HEAT repeats; Region: HEAT_2; pfam13646
326424006988	Type I restriction-modification system methyltransferase subunit [Defense mechanisms]; Region: HsdM; COG0286
326424006989	HsdM N-terminal domain; Region: HsdM_N; pfam12161
326424006990	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
326424006991	Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732
326424006992	Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420
326424006993	Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl15769
326424006994	TIGR03084 family protein; Region: TIGR03084
326424006995	Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; cl00986
326424006996	Wyosine base formation; Region: Wyosine_form; pfam08608
326424006997	Helix-turn-helix domains; Region: HTH; cl00088
326424006998	short chain dehydrogenase; Provisional; Region: PRK07041
326424006999	classical (c) SDRs; Region: SDR_c; cd05233
326424007000	NAD(P) binding site [chemical binding]; other site
326424007001	active site
326424007002	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
326424007003	Restriction endonuclease; Region: Mrr_cat; cl00516
326424007004	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cl00083
326424007005	SMI1 / KNR4 family (SUKH-1); Region: SMI1_KNR4; cl01747
326424007006	TIR domain; Region: TIR_2; cl15770
326424007007	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
326424007008	Tetratricopeptide repeat; Region: TPR_10; pfam13374
326424007009	Tetratricopeptide repeat; Region: TPR_10; pfam13374
326424007010	Tetratricopeptide repeat; Region: TPR_12; pfam13424
326424007011	Tetratricopeptide repeat; Region: TPR_12; pfam13424
326424007012	Tetratricopeptide repeat; Region: TPR_12; pfam13424
326424007013	Tetratricopeptide repeat; Region: TPR_12; pfam13424
326424007014	Tetratricopeptide repeat; Region: TPR_12; pfam13424
326424007015	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
326424007016	non-specific DNA binding site [nucleotide binding]; other site
326424007017	salt bridge; other site
326424007018	sequence-specific DNA binding site [nucleotide binding]; other site
326424007019	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
326424007020	Domain of unknown function (DUF4143); Region: DUF4143; pfam13635
326424007021	3-ketoacyl-(acyl-carrier-protein) reductase; Reviewed; Region: PRK12826
326424007022	classical (c) SDRs; Region: SDR_c; cd05233
326424007023	NAD(P) binding site [chemical binding]; other site
326424007024	active site
326424007025	Helix-turn-helix domains; Region: HTH; cl00088
326424007026	ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116
326424007027	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
326424007028	Walker A/P-loop; other site
326424007029	ATP binding site [chemical binding]; other site
326424007030	Q-loop/lid; other site
326424007031	ABC transporter signature motif; other site
326424007032	Walker B; other site
326424007033	D-loop; other site
326424007034	H-loop/switch region; other site
326424007035	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
326424007036	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
326424007037	dimer interface [polypeptide binding]; other site
326424007038	conserved gate region; other site
326424007039	putative PBP binding loops; other site
326424007040	ABC-ATPase subunit interface; other site
326424007041	ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728
326424007042	NMT1-like family; Region: NMT1_2; cl15260
326424007043	putative luciferase-like monooxygenase, FMN-dependent, CE1758 family; Region: LLM_CE1758_fam; TIGR04036
326424007044	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
326424007045	Luciferase-like monooxygenase; Region: Bac_luciferase; pfam00296
326424007046	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
326424007047	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
326424007048	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
326424007049	NAD(P) binding site [chemical binding]; other site
326424007050	active site
326424007051	Uncharacterized ACR, YkgG family COG1556; Region: DUF162; cl00674
326424007052	Uncharacterized conserved protein containing a ferredoxin-like domain [Energy production and conversion]; Region: COG1139
326424007053	Uncharacterized ACR, YkgG family COG1556; Region: DUF162; cl00674
326424007054	Domain of unknown function (DUF3390); Region: DUF3390; pfam11870
326424007055	Cysteine-rich domain; Region: CCG; pfam02754
326424007056	Cysteine-rich domain; Region: CCG; pfam02754
326424007057	Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031
326424007058	CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561
326424007059	dimer interface [polypeptide binding]; other site
326424007060	pyridoxal 5'-phosphate binding site [chemical binding]; other site
326424007061	catalytic residue [active]
326424007062	Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354
326424007063	trimer interface [polypeptide binding]; other site
326424007064	active site
326424007065	substrate binding site [chemical binding]; other site
326424007066	CoA binding site [chemical binding]; other site
326424007067	Catalytic domain of Bacillus cereus phosphatidylinositol-specific phospholipases C and similar proteins; Region: PI-PLCc_BcPLC_like; cd08586
326424007068	active site
326424007069	catalytic site [active]
326424007070	putative metal binding site [ion binding]; other site
326424007071	Tannase and feruloyl esterase; Region: Tannase; pfam07519
326424007072	Early set domain associated with the catalytic domain of sugar utilizing enzymes at either the N or C terminus; Region: E_set; cl09101
326424007073	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
326424007074	Helix-turn-helix domains; Region: HTH; cl00088
326424007075	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
326424007076	Helix-turn-helix domains; Region: HTH; cl00088
326424007077	Helix-turn-helix domains; Region: HTH; cl00088
326424007078	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
326424007079	drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711
326424007080	putative substrate translocation pore; other site
326424007081	Maf-like protein; Region: Maf; pfam02545
326424007082	Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555
326424007083	active site
326424007084	dimer interface [polypeptide binding]; other site
326424007085	hopanoid biosynthesis associated radical SAM protein HpnH; Region: HpnH; TIGR03470
326424007086	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
326424007087	FeS/SAM binding site; other site
326424007088	Domain of unknown function (DUF3463); Region: DUF3463; pfam11946
326424007089	Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cl00454
326424007090	urea ABC transporter, ATP-binding protein UrtD; Region: urea_trans_UrtD; TIGR03411
326424007091	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410
326424007092	LivF (TM1139) is part of the LIV-I bacterial ABC-type two-component transport system that imports neutral, branched-chain amino acids.  The  E. coli branched-chain amino acid transporter comprises a heterodimer of ABC transporters (LivF and LivG), a...; Region: ABC_TM1139_LivF_branched; cd03224
326424007093	Walker A/P-loop; other site
326424007094	ATP binding site [chemical binding]; other site
326424007095	Q-loop/lid; other site
326424007096	ABC transporter signature motif; other site
326424007097	Walker B; other site
326424007098	D-loop; other site
326424007099	H-loop/switch region; other site
326424007100	cyclohexanecarboxylate-CoA ligase; Reviewed; Region: PRK13295
326424007101	AMP-binding enzyme; Region: AMP-binding; cl15778
326424007102	putative beta-ketoacyl acyl carrier protein [ACP] reductase (BKR)-like, SDR; Region: BKR_like_SDR_like; cd05344
326424007103	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
326424007104	putative NAD(P) binding site [chemical binding]; other site
326424007105	putative active site [active]
326424007106	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; cl12078
326424007107	4Fe-4S single cluster domain; Region: Fer4_15; pfam13459
326424007108	Type I periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type active transport systems that are predicted to be involved in transport of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_7; cd06341
326424007109	Periplasmic binding protein; Region: Peripla_BP_6; pfam13458
326424007110	putative ligand binding site [chemical binding]; other site
326424007111	Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cl00200
326424007112	amphipathic channel; other site
326424007113	Asn-Pro-Ala signature motifs; other site
326424007114	Low molecular weight phosphatase family; Region: LMWPc; cd00115
326424007115	Low molecular weight phosphotyrosine protein phosphatase; Region: LMWPc; pfam01451
326424007116	active site
326424007117	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_20; cd07254
326424007118	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
326424007119	putative metal binding site [ion binding]; other site
326424007120	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
326424007121	dimerization interface [polypeptide binding]; other site
326424007122	putative DNA binding site [nucleotide binding]; other site
326424007123	putative Zn2+ binding site [ion binding]; other site
326424007124	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; cl11587
326424007125	The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509
326424007126	active site 2 [active]
326424007127	active site 1 [active]
326424007128	The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509
326424007129	Acyl-CoA dehydrogenase (ACAD) 10 and 11, N-terminal domain, and similar proteins. This subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: ACAD10_11_like; cd05154
326424007130	Phosphotransferase enzyme family; Region: APH; pfam01636
326424007131	putative active site [active]
326424007132	putative substrate binding site [chemical binding]; other site
326424007133	ATP binding site [chemical binding]; other site
326424007134	probable F420-dependent oxidoreductase, MSMEG_2249 family; Region: F420_MSMEG_2249; TIGR03857
326424007135	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
326424007136	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
326424007137	Mycobacterium tuberculosis aldehyde dehydrogenase AldA-like; Region: ALDH_AldA-Rv0768; cd07139
326424007138	NAD binding site [chemical binding]; other site
326424007139	catalytic residues [active]
326424007140	oxidoreductase, Rxyl_3153 family; Region: Rxyl_3153; TIGR03989
326424007141	Class III alcohol dehydrogenase; Region: Zn_ADH_class_III; cd08279
326424007142	NAD binding site [chemical binding]; other site
326424007143	catalytic Zn binding site [ion binding]; other site
326424007144	substrate binding site [chemical binding]; other site
326424007145	structural Zn binding site [ion binding]; other site
326424007146	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; cl12078
326424007147	Cupin domain; Region: Cupin_2; cl09118
326424007148	Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670
326424007149	Siderophore biosynthesis protein domain; Region: AlcB; smart01006
326424007150	N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357
326424007151	Domain of unknown function (DUF222); Region: DUF222; pfam02720
326424007152	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
326424007153	active site
326424007154	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
326424007155	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
326424007156	CoenzymeA binding site [chemical binding]; other site
326424007157	subunit interaction site [polypeptide binding]; other site
326424007158	PHB binding site; other site
326424007159	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
326424007160	CoenzymeA binding site [chemical binding]; other site
326424007161	subunit interaction site [polypeptide binding]; other site
326424007162	PHB binding site; other site
326424007163	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
326424007164	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
326424007165	active site
326424007166	Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804
326424007167	CoA-transferase family III; Region: CoA_transf_3; pfam02515
326424007168	Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072
326424007169	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
326424007170	Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109
326424007171	ferredoxin-NADP+ reductase; Region: PLN02852
326424007172	Periplasmic binding protein; Region: Peripla_BP_6; pfam13458
326424007173	Type I periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type active transport systems that are predicted to be involved in transport of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_7; cd06341
326424007174	putative ligand binding site [chemical binding]; other site
326424007175	cyclohexanecarboxylate-CoA ligase; Reviewed; Region: PRK13295
326424007176	AMP-binding enzyme; Region: AMP-binding; cl15778
326424007177	AMP-binding enzyme; Region: AMP-binding; cl15778
326424007178	3-(3-hydroxyphenyl)propionate hydroxylase; Validated; Region: mhpA; PRK06183
326424007179	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
326424007180	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
326424007181	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
326424007182	Protein of unknown function (DUF1271); Region: DUF1271; cl01443
326424007183	4Fe-4S single cluster domain; Region: Fer4_15; pfam13459
326424007184	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
326424007185	substrate binding site [chemical binding]; other site
326424007186	oxyanion hole (OAH) forming residues; other site
326424007187	trimer interface [polypeptide binding]; other site
326424007188	Isochorismatase family; Region: Isochorismatase; pfam00857
326424007189	Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431
326424007190	catalytic triad [active]
326424007191	conserved cis-peptide bond; other site
326424007192	cyclohexanecarboxylate-CoA ligase; Reviewed; Region: PRK13295
326424007193	AMP-binding enzyme; Region: AMP-binding; cl15778
326424007194	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
326424007195	long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187
326424007196	AMP-binding enzyme; Region: AMP-binding; cl15778
326424007197	AMP-binding enzyme; Region: AMP-binding; cl15778
326424007198	Ring hydroxylating dioxygenase beta subunit. This subunit has a similar structure to NTF-2, Ketosteroid isomerase and scytalone dehydratase.The degradation of aromatic compounds by aerobic bacteria frequently begins with the dihydroxylation of the...; Region: ring_hydroxylating_dioxygenases_beta; cd00667
326424007199	inter-subunit interface; other site
326424007200	Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638
326424007201	Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938
326424007202	iron-sulfur cluster [ion binding]; other site
326424007203	[2Fe-2S] cluster binding site [ion binding]; other site
326424007204	C-terminal catalytic domain of the oxygenase alpha subunit of Pseudomonas resinovorans strain CA10 anthranilate 1,2-dioxygenase and related aromatic ring hydroxylating dioxygenases; Region: RHO_alpha_C_AntDO-like; cd08879
326424007205	putative alpha subunit interface [polypeptide binding]; other site
326424007206	putative active site [active]
326424007207	putative substrate binding site [chemical binding]; other site
326424007208	Fe binding site [ion binding]; other site
326424007209	Rubredoxin-like zinc ribbon domain (DUF35_N); Region: DUF35_N; pfam12172
326424007210	DUF35 OB-fold domain; Region: DUF35; pfam01796
326424007211	thiolase; Provisional; Region: PRK06158
326424007212	Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2  has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829
326424007213	active site
326424007214	The single-domain 2,3-dihydroxybiphenyl 1,2-dioxygenases (BphC, EC 1.13.11.39) from Rhodococcus globerulus P6, BphC2-RGP6 and BphC3-RGP6,  and similar proteins; Region: BphC2-C3-RGP6_C_like; cd08348
326424007215	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
326424007216	putative active site [active]
326424007217	putative metal binding site [ion binding]; other site
326424007218	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
326424007219	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
326424007220	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
326424007221	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421
326424007222	2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase [Carbohydrate transport and metabolism]; Region: HpcH; COG3836
326424007223	Pyruvate kinase (PK):  Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl09155
326424007224	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
326424007225	Uncharacterized Candidatus pelagibacter aldehyde dehydrogenase, DhaS-like; Region: ALDH_DhaS; cd07114
326424007226	NAD(P) binding site [chemical binding]; other site
326424007227	catalytic residues [active]
326424007228	Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804
326424007229	CoA-transferase family III; Region: CoA_transf_3; pfam02515
326424007230	Domain of unknown function (DUF222); Region: DUF222; pfam02720
326424007231	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
326424007232	active site
326424007233	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
326424007234	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
326424007235	active site
326424007236	FkbR2 is a Streptomyces hygroscopicus protein with a hot dog fold that belongs to a conserved family of proteins found in prokaryotes and archaea but not in eukaryotes. FkbR2  has sequence similarity to (R)-specific enoyl-CoA hydratase, the peroxisomal...; Region: FkbR2; cd03451
326424007237	putative active site [active]
326424007238	putative catalytic site [active]
326424007239	pimeloyl-CoA dehydrogenase, large subunit; Region: pimC_large; TIGR03204
326424007240	Putative acyl-CoA dehydrogenases similar to fadE6, fadE17, and fadE26; Region: ACAD_fadE6_17_26; cd01152
326424007241	FAD binding site [chemical binding]; other site
326424007242	substrate binding site [chemical binding]; other site
326424007243	catalytic base [active]
326424007244	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
326424007245	active site
326424007246	thiolase; Provisional; Region: PRK06158
326424007247	Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2  has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829
326424007248	active site
326424007249	long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07656
326424007250	AMP-binding enzyme; Region: AMP-binding; cl15778
326424007251	AMP-binding enzyme; Region: AMP-binding; cl15778
326424007252	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
326424007253	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
326424007254	NAD(P) binding site [chemical binding]; other site
326424007255	active site
326424007256	Rubredoxin-like zinc ribbon domain (DUF35_N); Region: DUF35_N; pfam12172
326424007257	DUF35 OB-fold domain; Region: DUF35; pfam01796
326424007258	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
326424007259	enoyl-CoA hydratase; Provisional; Region: PRK06688
326424007260	substrate binding site [chemical binding]; other site
326424007261	oxyanion hole (OAH) forming residues; other site
326424007262	trimer interface [polypeptide binding]; other site
326424007263	3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565
326424007264	classical (c) SDRs; Region: SDR_c; cd05233
326424007265	NAD(P) binding site [chemical binding]; other site
326424007266	active site
326424007267	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
326424007268	probable F420-dependent oxidoreductase, Rv2161c family; Region: F420_Rv2161c; TIGR03619
326424007269	mycofactocin system transcriptional regulator; Region: mycofact_TetR; TIGR03968
326424007270	Helix-turn-helix domains; Region: HTH; cl00088
326424007271	Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109
326424007272	Flavin Reductases; Region: FlaRed; cl00801
326424007273	Pyruvate kinase (PK):  Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl09155
326424007274	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
326424007275	Helix-turn-helix domains; Region: HTH; cl00088
326424007276	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
326424007277	Helix-turn-helix domains; Region: HTH; cl00088
326424007278	alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289
326424007279	NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604
326424007280	putative NAD(P) binding site [chemical binding]; other site
326424007281	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
326424007282	probable F420-dependent oxidoreductase, Rv1855c family; Region: F420_Rv1855c; TIGR03560
326424007283	Nitronate monooxygenase; Region: NMO; pfam03060
326424007284	2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730
326424007285	FMN binding site [chemical binding]; other site
326424007286	substrate binding site [chemical binding]; other site
326424007287	putative catalytic residue [active]
326424007288	inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK03708
326424007289	Diacylglycerol kinase catalytic domain; Region: DAGK_cat; cl01255
326424007290	Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247
326424007291	N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357
326424007292	chorismate binding enzyme; Region: Chorismate_bind; cl10555
326424007293	Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020
326424007294	Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020
326424007295	conserved cys residue [active]
326424007296	putative luciferase-like monooxygenase, FMN-dependent, CE1758 family; Region: LLM_CE1758_fam; TIGR04036
326424007297	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
326424007298	Helix-turn-helix domains; Region: HTH; cl00088
326424007299	Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR2; cd08268
326424007300	putative NAD(P) binding site [chemical binding]; other site
326424007301	YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448
326424007302	homotrimer interaction site [polypeptide binding]; other site
326424007303	putative active site [active]
326424007304	Phosphopantetheine attachment site; Region: PP-binding; cl09936
326424007305	polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833
326424007306	Beta-ketoacyl synthase; Region: PKS_KS; smart00825
326424007307	active site
326424007308	malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128
326424007309	Acyl transferase domain; Region: Acyl_transf_1; cl08282
326424007310	ketoreductase (KR), subgroup 1, complex (x) SDRs; Region: KR_1_SDR_x; cd08952
326424007311	NADP binding site [chemical binding]; other site
326424007312	active site
326424007313	Phosphopantetheine attachment site; Region: PP-binding; cl09936
326424007314	Thioesterase; Region: PKS_TE; smart00824
326424007315	glycerophosphodiester phosphodiesterase; Provisional; Region: glpQ; PRK11143
326424007316	Glycerophosphodiester phosphodiesterase domain of Streptomycin coelicolor (GlpQ1) and similar proteins; Region: GDPD_ScGlpQ1_like; cd08602
326424007317	putative active site [active]
326424007318	catalytic site [active]
326424007319	putative metal binding site [ion binding]; other site
326424007320	The Delta9 Fatty Acid Desaturase (Delta9-FADS)-like CD includes the delta-9 and delta-11 acyl CoA desaturases found in various eukaryotes including vertebrates, insects, higher plants, and fungi. The delta-9 acyl-lipid desaturases are found in a wide...; Region: Delta9-FADS-like; cd03505
326424007321	Fatty acid desaturase; Region: FA_desaturase; pfam00487
326424007322	Di-iron ligands [ion binding]; other site
326424007323	The Delta9 Fatty Acid Desaturase (Delta9-FADS)-like CD includes the delta-9 and delta-11 acyl CoA desaturases found in various eukaryotes including vertebrates, insects, higher plants, and fungi. The delta-9 acyl-lipid desaturases are found in a wide...; Region: Delta9-FADS-like; cd03505
326424007324	Phosphopantetheine attachment site; Region: PP-binding; cl09936
326424007325	Mycolic acid cyclopropane synthetase; Region: CMAS; pfam02353
326424007326	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
326424007327	S-adenosylmethionine binding site [chemical binding]; other site
326424007328	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; cl12078
326424007329	acyl-CoA synthetase; Validated; Region: PRK05850
326424007330	AMP-binding enzyme; Region: AMP-binding; cl15778
326424007331	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
326424007332	CoenzymeA binding site [chemical binding]; other site
326424007333	subunit interaction site [polypeptide binding]; other site
326424007334	PHB binding site; other site
326424007335	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632
326424007336	Domain of unknown function (DUF222); Region: DUF222; pfam02720
326424007337	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
326424007338	active site
326424007339	FAD binding domain; Region: FAD_binding_3; pfam01494
326424007340	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
326424007341	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
326424007342	hypothetical protein; Provisional; Region: PRK06184
326424007343	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
326424007344	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
326424007345	CoenzymeA binding site [chemical binding]; other site
326424007346	subunit interaction site [polypeptide binding]; other site
326424007347	PHB binding site; other site
326424007348	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
326424007349	CoenzymeA binding site [chemical binding]; other site
326424007350	subunit interaction site [polypeptide binding]; other site
326424007351	PHB binding site; other site
326424007352	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
326424007353	3-hydroxybutyrate dehydrogenase; Region: PHB_DH; TIGR01963
326424007354	NAD(P) binding site [chemical binding]; other site
326424007355	active site
326424007356	Transcriptional regulators [Transcription]; Region: FadR; COG2186
326424007357	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
326424007358	DNA-binding site [nucleotide binding]; DNA binding site
326424007359	FCD domain; Region: FCD; cl11656
326424007360	pimeloyl-CoA dehydrogenase, small subunit; Region: pimD_small; TIGR03203
326424007361	Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771
326424007362	Acyl-CoA dehydrogenase; Region: ACAD; cd00567
326424007363	active site
326424007364	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
326424007365	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
326424007366	active site
326424007367	Transcriptional regulators [Transcription]; Region: FadR; COG2186
326424007368	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
326424007369	DNA-binding site [nucleotide binding]; DNA binding site
326424007370	FCD domain; Region: FCD; cl11656
326424007371	Periplasmic binding protein; Region: Peripla_BP_6; pfam13458
326424007372	Type I periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type active transport systems that are predicted to be involved in transport of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_7; cd06341
326424007373	putative ligand binding site [chemical binding]; other site
326424007374	CoA-transferase family III; Region: CoA_transf_3; pfam02515
326424007375	putative phosphoketolase; Provisional; Region: PRK05261
326424007376	Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629
326424007377	TPP-binding site [chemical binding]; other site
326424007378	D-xylulose 5-phosphate/D-fructose 6-phosphate phosphoketolase; Region: XFP; pfam03894
326424007379	XFP C-terminal domain; Region: XFP_C; pfam09363
326424007380	Acetyl-CoA hydrolase [Energy production and conversion]; Region: ACH1; COG0427
326424007381	SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339
326424007382	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl09944
326424007383	active site
326424007384	dimerization interface [polypeptide binding]; other site
326424007385	Glycosyl hydrolases family 15; Region: Glyco_hydro_15; pfam00723
326424007386	short chain dehydrogenase; Provisional; Region: PRK07109
326424007387	classical (c) SDR, subgroup 3; Region: SDR_c3; cd05360
326424007388	putative NAD(P) binding site [chemical binding]; other site
326424007389	active site
326424007390	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
326424007391	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
326424007392	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
326424007393	NAD(P) binding site [chemical binding]; other site
326424007394	active site
326424007395	Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804
326424007396	CoA-transferase family III; Region: CoA_transf_3; pfam02515
326424007397	3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565
326424007398	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
326424007399	NAD(P) binding site [chemical binding]; other site
326424007400	active site
326424007401	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
326424007402	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
326424007403	pantoate--beta-alanine ligase; Region: panC; TIGR00018
326424007404	active site
326424007405	nucleotide binding site [chemical binding]; other site
326424007406	HIGH motif; other site
326424007407	KMSKS motif; other site
326424007408	enoyl-CoA hydratase; Provisional; Region: PRK08290
326424007409	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
326424007410	substrate binding site [chemical binding]; other site
326424007411	oxyanion hole (OAH) forming residues; other site
326424007412	trimer interface [polypeptide binding]; other site
326424007413	long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187
326424007414	AMP-binding enzyme; Region: AMP-binding; cl15778
326424007415	Isochorismatase family; Region: Isochorismatase; pfam00857
326424007416	Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431
326424007417	catalytic triad [active]
326424007418	conserved cis-peptide bond; other site
326424007419	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
326424007420	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587
326424007421	active site
326424007422	metal binding site [ion binding]; metal-binding site
326424007423	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
326424007424	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587
326424007425	active site
326424007426	metal binding site [ion binding]; metal-binding site
326424007427	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
326424007428	Helix-turn-helix domains; Region: HTH; cl00088
326424007429	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
326424007430	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
326424007431	pimeloyl-CoA dehydrogenase, large subunit; Region: pimC_large; TIGR03204
326424007432	active site
326424007433	Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024
326424007434	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
326424007435	substrate binding site [chemical binding]; other site
326424007436	oxyanion hole (OAH) forming residues; other site
326424007437	trimer interface [polypeptide binding]; other site
326424007438	Rubredoxin-like zinc ribbon domain (DUF35_N); Region: DUF35_N; pfam12172
326424007439	DUF35 OB-fold domain; Region: DUF35; pfam01796
326424007440	lipid-transfer protein; Provisional; Region: PRK07855
326424007441	Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2  has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829
326424007442	active site
326424007443	NodN (nodulation factor N) contains a single hot dog fold similar to those of the peroxisomal Hydratase-Dehydrogenase-Epimerase (HDE) protein, and the fatty acid synthase beta subunit.  Rhizobium and related species form nodules on the roots of their...; Region: NodN; cd03450
326424007444	putative active site [active]
326424007445	putative catalytic site [active]
326424007446	Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804
326424007447	CoA-transferase family III; Region: CoA_transf_3; pfam02515
326424007448	cyclohexanecarboxylate-CoA ligase; Reviewed; Region: PRK13295
326424007449	AMP-binding enzyme; Region: AMP-binding; cl15778
326424007450	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
326424007451	Helix-turn-helix domains; Region: HTH; cl00088
326424007452	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
326424007453	Luciferase-like monooxygenase; Region: Bac_luciferase; pfam00296
326424007454	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
326424007455	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
326424007456	Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638
326424007457	Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938
326424007458	iron-sulfur cluster [ion binding]; other site
326424007459	[2Fe-2S] cluster binding site [ion binding]; other site
326424007460	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
326424007461	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
326424007462	active site
326424007463	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
326424007464	Predicted nucleic-acid-binding protein containing a Zn-ribbon [General function prediction only]; Region: COG1545
326424007465	DUF35 OB-fold domain; Region: DUF35; pfam01796
326424007466	acetyl-CoA acetyltransferase; Provisional; Region: PRK06064
326424007467	Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2  has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829
326424007468	active site
326424007469	butyryl-CoA:acetate CoA-transferase; Region: butyr_acet_CoA; TIGR03948
326424007470	SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339
326424007471	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
326424007472	active site
326424007473	ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488
326424007474	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
326424007475	Walker A/P-loop; other site
326424007476	ATP binding site [chemical binding]; other site
326424007477	Q-loop/lid; other site
326424007478	ABCF_EF-3  Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth.  EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221
326424007479	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
326424007480	ABC transporter signature motif; other site
326424007481	Walker B; other site
326424007482	D-loop; other site
326424007483	H-loop/switch region; other site
326424007484	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
326424007485	Helix-turn-helix domains; Region: HTH; cl00088
326424007486	putative luciferase-like monooxygenase, FMN-dependent, CE1758 family; Region: LLM_CE1758_fam; TIGR04036
326424007487	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
326424007488	long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187
326424007489	AMP-binding enzyme; Region: AMP-binding; cl15778
326424007490	Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771
326424007491	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
326424007492	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
326424007493	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
326424007494	active site
326424007495	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
326424007496	NAD(P) binding site [chemical binding]; other site
326424007497	active site
326424007498	Rubredoxin-like zinc ribbon domain (DUF35_N); Region: DUF35_N; pfam12172
326424007499	acetyl-CoA acetyltransferase; Provisional; Region: PRK06064
326424007500	Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2  has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829
326424007501	active site
326424007502	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
326424007503	NAD(P) binding site [chemical binding]; other site
326424007504	active site
326424007505	Protein of unknown function (DUF2889); Region: DUF2889; pfam11136
326424007506	cyclohexanecarboxylate-CoA ligase; Reviewed; Region: PRK13295
326424007507	AMP-binding enzyme; Region: AMP-binding; cl15778
326424007508	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
326424007509	Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804
326424007510	CoA-transferase family III; Region: CoA_transf_3; pfam02515
326424007511	Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804
326424007512	Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109
326424007513	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
326424007514	Helix-turn-helix domains; Region: HTH; cl00088
326424007515	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
326424007516	Periplasmic binding protein; Region: Peripla_BP_6; pfam13458
326424007517	Type I periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type active transport systems that are predicted to be involved in transport of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_7; cd06341
326424007518	putative ligand binding site [chemical binding]; other site
326424007519	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
326424007520	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
326424007521	NAD(P) binding site [chemical binding]; other site
326424007522	active site
326424007523	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
326424007524	TM-ABC transporter signature motif; other site
326424007525	Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cl00454
326424007526	TM-ABC transporter signature motif; other site
326424007527	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411
326424007528	The Mj1267/LivG ABC transporter subfamily is involved in the transport of the hydrophobic amino acids leucine, isoleucine and valine.  MJ1267 is a branched-chain amino acid transporter with 29% similarity to both the LivF and LivG components of the E; Region: ABC_Mj1267_LivG_branched; cd03219
326424007529	Walker A/P-loop; other site
326424007530	ATP binding site [chemical binding]; other site
326424007531	Q-loop/lid; other site
326424007532	ABC transporter signature motif; other site
326424007533	Walker B; other site
326424007534	D-loop; other site
326424007535	H-loop/switch region; other site
326424007536	LivF (TM1139) is part of the LIV-I bacterial ABC-type two-component transport system that imports neutral, branched-chain amino acids.  The  E. coli branched-chain amino acid transporter comprises a heterodimer of ABC transporters (LivF and LivG), a...; Region: ABC_TM1139_LivF_branched; cd03224
326424007537	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410
326424007538	Walker A/P-loop; other site
326424007539	ATP binding site [chemical binding]; other site
326424007540	Q-loop/lid; other site
326424007541	ABC transporter signature motif; other site
326424007542	Walker B; other site
326424007543	D-loop; other site
326424007544	H-loop/switch region; other site
326424007545	Periplasmic binding protein; Region: Peripla_BP_6; pfam13458
326424007546	Type I periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type active transport systems that are predicted to be involved in transport of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_7; cd06341
326424007547	putative ligand binding site [chemical binding]; other site
326424007548	Transcriptional regulators [Transcription]; Region: FadR; COG2186
326424007549	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
326424007550	DNA-binding site [nucleotide binding]; DNA binding site
326424007551	FCD domain; Region: FCD; cl11656
326424007552	Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415
326424007553	Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415
326424007554	Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415
326424007555	Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415
326424007556	Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415
326424007557	Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415
326424007558	pimeloyl-CoA dehydrogenase, small subunit; Region: pimD_small; TIGR03203
326424007559	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
326424007560	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
326424007561	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
326424007562	active site
326424007563	Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804
326424007564	CoA-transferase family III; Region: CoA_transf_3; pfam02515
326424007565	Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109
326424007566	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
326424007567	NAD(P) binding site [chemical binding]; other site
326424007568	active site
326424007569	classical (c) SDRs; Region: SDR_c; cd05233
326424007570	NAD(P) binding site [chemical binding]; other site
326424007571	active site
326424007572	probable F420-dependent oxidoreductase, Rv2161c family; Region: F420_Rv2161c; TIGR03619
326424007573	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
326424007574	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
326424007575	NAD(P) binding site [chemical binding]; other site
326424007576	active site
326424007577	Helix-turn-helix domains; Region: HTH; cl00088
326424007578	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
326424007579	substrate binding site [chemical binding]; other site
326424007580	oxyanion hole (OAH) forming residues; other site
326424007581	trimer interface [polypeptide binding]; other site
326424007582	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
326424007583	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
326424007584	Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cl00161
326424007585	Branched-chain amino acid transport protein (AzlD); Region: AzlD; cl00735
326424007586	AzlC protein; Region: AzlC; cl00570
326424007587	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
326424007588	Helix-turn-helix domains; Region: HTH; cl00088
326424007589	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
326424007590	Helix-turn-helix domains; Region: HTH; cl00088
326424007591	3-ketoacyl-(acyl-carrier-protein) reductase; Reviewed; Region: PRK12826
326424007592	classical (c) SDRs; Region: SDR_c; cd05233
326424007593	NAD(P) binding site [chemical binding]; other site
326424007594	active site
326424007595	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
326424007596	Rhodococcus ruber 6-oxolauric acid dehydrogenase-like and related proteins; Region: ALDH_CddD-AldA-like; cd07089
326424007597	NAD binding site [chemical binding]; other site
326424007598	catalytic residues [active]
326424007599	AMP-binding enzyme; Region: AMP-binding; cl15778
326424007600	acyl-CoA synthetase; Validated; Region: PRK06178
326424007601	Periplasmic binding protein; Region: Peripla_BP_6; pfam13458
326424007602	Type I periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type active transport systems that are predicted to be involved in transport of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_7; cd06341
326424007603	putative ligand binding site [chemical binding]; other site
326424007604	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
326424007605	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
326424007606	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; cl11611
326424007607	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
326424007608	Helix-turn-helix domains; Region: HTH; cl00088
326424007609	Helix-turn-helix domains; Region: HTH; cl00088
326424007610	Helix-turn-helix domains; Region: HTH; cl00088
326424007611	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
326424007612	Predicted aminoglycoside phosphotransferase [General function prediction only]; Region: COG3173
326424007613	Acyl-CoA dehydrogenase (ACAD) 10 and 11, N-terminal domain, and similar proteins. This subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: ACAD10_11_like; cd05154
326424007614	putative active site [active]
326424007615	putative substrate binding site [chemical binding]; other site
326424007616	ATP binding site [chemical binding]; other site
326424007617	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557
326424007618	classical (c) SDRs; Region: SDR_c; cd05233
326424007619	NAD(P) binding site [chemical binding]; other site
326424007620	active site
326424007621	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
326424007622	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
326424007623	active site
326424007624	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
326424007625	Helix-turn-helix domains; Region: HTH; cl00088
326424007626	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
326424007627	Helix-turn-helix domains; Region: HTH; cl00088
326424007628	Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cl00230
326424007629	Putative undecaprenyl diphosphate synthase; Region: Prenyltransf; pfam01255
326424007630	catalytic residue [active]
326424007631	putative FPP diphosphate  binding site; other site
326424007632	putative FPP binding hydrophobic cleft; other site
326424007633	dimer interface [polypeptide binding]; other site
326424007634	putative IPP diphosphate binding site; other site
326424007635	Prokaryotic protein of unknown function (DUF849); Region: DUF849; cl15827
326424007636	mycofactocin system transcriptional regulator; Region: mycofact_TetR; TIGR03968
326424007637	Helix-turn-helix domains; Region: HTH; cl00088
326424007638	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
326424007639	putative FMN-dependent luciferase-like monooxygenase, KPN_01858 family; Region: LLM_KPN_01858; TIGR04027
326424007640	mycofactocin precursor; Region: mycofactocin; TIGR03969
326424007641	mycofactocin system RPExFGAL protein; Region: Ac_RPExFGAL; TIGR03967
326424007642	mycofactocin radical SAM maturase; Region: rSAM_MSMEG_1423; TIGR03962
326424007643	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
326424007644	FeS/SAM binding site; other site
326424007645	Domain of unknown function (DUF4008); Region: DUF4008; cl14869
326424007646	Helix-turn-helix domains; Region: HTH; cl00088
326424007647	YceI-like domain; Region: YceI; cl01001
326424007648	heme/flavin dehydrogenase, mycofactocin system; Region: actino_HemFlav; TIGR03966
326424007649	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl09108
326424007650	phosphate binding site [ion binding]; other site
326424007651	Periplasmic binding protein; Region: Peripla_BP_6; pfam13458
326424007652	Type I periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type active transport systems that are predicted to be involved in transport of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_7; cd06341
326424007653	putative ligand binding site [chemical binding]; other site
326424007654	haloacid dehalogenase superfamily, subfamily IA, variant 3 with third motif having DD or ED; Region: HAD-SF-IA-v3; TIGR01509
326424007655	Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391
326424007656	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
326424007657	motif II; other site
326424007658	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
326424007659	PAP2_like proteins, Aur1_like subfamily. Yeast Aur1p or Ipc1p is necessary for the addition of inositol phosphate to ceramide, an essential step in yeast sphingolipid synthesis, and is the target of several antifungal compounds such as aureobasidin; Region: PAP2_Aur1_like; cd03386
326424007660	active site
326424007661	Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804
326424007662	CoA-transferase family III; Region: CoA_transf_3; pfam02515
326424007663	CoA-transferase family III; Region: CoA_transf_3; pfam02515
326424007664	Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804
326424007665	Predicted glutamine amidotransferase [General function prediction only]; Region: COG0121
326424007666	Glutamine amidotransferases class-II (Gn-AT)_YafJ-type.  YafJ is a glutamine amidotransferase-like protein of unknown function found in prokaryotes, eukaryotes and archaea.  YafJ has a conserved structural fold similar to those of other class II...; Region: YafJ; cd01908
326424007667	putative active site [active]
326424007668	putative dimer interface [polypeptide binding]; other site
326424007669	PAS domain; Region: PAS_9; pfam13426
326424007670	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
326424007671	putative active site [active]
326424007672	heme pocket [chemical binding]; other site
326424007673	PAS domain S-box; Region: sensory_box; TIGR00229
326424007674	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
326424007675	metal binding site [ion binding]; metal-binding site
326424007676	active site
326424007677	I-site; other site
326424007678	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
326424007679	Helix-turn-helix domains; Region: HTH; cl00088
326424007680	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
326424007681	Major Facilitator Superfamily; Region: MFS_1; pfam07690
326424007682	putative substrate translocation pore; other site
326424007683	Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which  binds to Adenosine nucleotide; Region: AANH_like; cl00292
326424007684	Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381
326424007685	Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804
326424007686	CoA-transferase family III; Region: CoA_transf_3; pfam02515
326424007687	Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109
326424007688	Helix-turn-helix domains; Region: HTH; cl00088
326424007689	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
326424007690	dimerization interface [polypeptide binding]; other site
326424007691	shikimate kinase; Reviewed; Region: aroK; PRK00131
326424007692	Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464
326424007693	ADP binding site [chemical binding]; other site
326424007694	magnesium binding site [ion binding]; other site
326424007695	putative shikimate binding site; other site
326424007696	Domain of unknown function (DUF1932); Region: DUF1932; pfam09130
326424007697	Rubredoxin-like zinc ribbon domain (DUF35_N); Region: DUF35_N; pfam12172
326424007698	DUF35 OB-fold domain; Region: DUF35; pfam01796
326424007699	dihydrolipoamide dehydrogenase; Reviewed; Region: PRK07818
326424007700	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
326424007701	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
326424007702	Helix-turn-helix domains; Region: HTH; cl00088
326424007703	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
326424007704	NAD(P) binding site [chemical binding]; other site
326424007705	active site
326424007706	Helix-turn-helix domains; Region: HTH; cl00088
326424007707	acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946
326424007708	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
326424007709	putative substrate translocation pore; other site
326424007710	MFS transporter, sugar porter (SP) family; Region: SP; TIGR00879
326424007711	Leucine carboxyl methyltransferase; Region: LCM; cl01306
326424007712	Domain of unknown function (DUF4062); Region: DUF4062; pfam13271
326424007713	NB-ARC domain; Region: NB-ARC; pfam00931
326424007714	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
326424007715	FOG: WD40 repeat [General function prediction only]; Region: COG2319
326424007716	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200
326424007717	structural tetrad; other site
326424007718	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200
326424007719	structural tetrad; other site
326424007720	classical (c) SDRs; Region: SDR_c; cd05233
326424007721	NAD(P) binding site [chemical binding]; other site
326424007722	active site
326424007723	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
326424007724	NAD(P) binding site [chemical binding]; other site
326424007725	active site
326424007726	Helix-turn-helix domains; Region: HTH; cl00088
326424007727	ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4152
326424007728	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
326424007729	Walker A/P-loop; other site
326424007730	ATP binding site [chemical binding]; other site
326424007731	Q-loop/lid; other site
326424007732	ABC transporter signature motif; other site
326424007733	Walker B; other site
326424007734	D-loop; other site
326424007735	H-loop/switch region; other site
326424007736	Domain of unknown function (DUF4162); Region: DUF4162; pfam13732
326424007737	ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698
326424007738	ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259
326424007739	N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793
326424007740	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
326424007741	active site
326424007742	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
326424007743	dimerization interface [polypeptide binding]; other site
326424007744	putative DNA binding site [nucleotide binding]; other site
326424007745	putative Zn2+ binding site [ion binding]; other site
326424007746	Cation efflux family; Region: Cation_efflux; cl00316
326424007747	Anti-sigma-K factor rskA; Region: RskA; pfam10099
326424007748	RNA polymerase sigma factor SigK; Reviewed; Region: PRK09646
326424007749	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
326424007750	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
326424007751	DNA binding residues [nucleotide binding]
326424007752	Protein of unknown function (DUF692); Region: DUF692; cl01263
326424007753	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
326424007754	S-adenosylmethionine binding site [chemical binding]; other site
326424007755	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447
326424007756	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447
326424007757	nudix motif; other site
326424007758	nudix motif; other site
326424007759	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
326424007760	NAD(P) binding site [chemical binding]; other site
326424007761	active site
326424007762	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
326424007763	salt bridge; other site
326424007764	non-specific DNA binding site [nucleotide binding]; other site
326424007765	sequence-specific DNA binding site [nucleotide binding]; other site
326424007766	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
326424007767	S-adenosylmethionine binding site [chemical binding]; other site
326424007768	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009
326424007769	short chain dehydrogenase; Provisional; Region: PRK06180
326424007770	17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374
326424007771	NADP binding site [chemical binding]; other site
326424007772	active site
326424007773	steroid binding site; other site
326424007774	Tn3 transposase DDE domain; Region: DDE_Tnp_Tn3; cl14901
326424007775	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
326424007776	Helix-turn-helix domains; Region: HTH; cl00088
326424007777	Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109
326424007778	Helix-turn-helix domains; Region: HTH; cl00088
326424007779	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
326424007780	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
326424007781	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
326424007782	Coenzyme A binding pocket [chemical binding]; other site
326424007783	Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834
326424007784	beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150
326424007785	dimer interface [polypeptide binding]; other site
326424007786	active site
326424007787	FtsX-like permease family; Region: FtsX; cl15850
326424007788	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
326424007789	This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE).  They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255
326424007790	Walker A/P-loop; other site
326424007791	ATP binding site [chemical binding]; other site
326424007792	Q-loop/lid; other site
326424007793	ABC transporter signature motif; other site
326424007794	Walker B; other site
326424007795	D-loop; other site
326424007796	H-loop/switch region; other site
326424007797	Helix-turn-helix domains; Region: HTH; cl00088
326424007798	Epoxide hydrolase N terminus; Region: EHN; pfam06441
326424007799	Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381
326424007800	MOSC domain; Region: MOSC; pfam03473
326424007801	amidase; Provisional; Region: PRK06170
326424007802	Amidase; Region: Amidase; cl11426
326424007803	3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: PRK12859
326424007804	classical (c) SDRs; Region: SDR_c; cd05233
326424007805	NAD(P) binding site [chemical binding]; other site
326424007806	active site
326424007807	Helix-turn-helix domains; Region: HTH; cl00088
326424007808	Predicted integral membrane proteins containing uncharacterized repeats [Function unknown]; Region: COG5563
326424007809	probable extracellular repeat, HAF family; Region: HAF_rpt; TIGR02913
326424007810	probable extracellular repeat, HAF family; Region: HAF_rpt; TIGR02913
326424007811	uridine kinase; Validated; Region: PRK06696
326424007812	Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cd02019
326424007813	active site
326424007814	Tn3 transposase DDE domain; Region: DDE_Tnp_Tn3; cl14901
326424007815	SNARE associated Golgi protein; Region: SNARE_assoc; cl00429
326424007816	Bacitracin resistance protein BacA; Region: BacA; cl00858
326424007817	ABC-2 type transporter; Region: ABC2_membrane; cl11417
326424007818	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
326424007819	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
326424007820	Walker A/P-loop; other site
326424007821	ATP binding site [chemical binding]; other site
326424007822	Q-loop/lid; other site
326424007823	ABC transporter signature motif; other site
326424007824	Walker B; other site
326424007825	D-loop; other site
326424007826	H-loop/switch region; other site
326424007827	Helix-turn-helix domains; Region: HTH; cl00088
326424007828	Peptidase family M48; Region: Peptidase_M48; cl12018
326424007829	Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cl00246
326424007830	FAD binding site [chemical binding]; other site
326424007831	NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604
326424007832	alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289
326424007833	putative NAD(P) binding site [chemical binding]; other site
326424007834	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
326424007835	Coenzyme A binding pocket [chemical binding]; other site
326424007836	N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357
326424007837	2-phosphosulpholactate phosphatase; Region: 2-ph_phosp; cl00895
326424007838	Phosphosulfolactate phosphohydrolase and related enzymes [Coenzyme metabolism / General function prediction only]; Region: COG2045
326424007839	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
326424007840	Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cl00161
326424007841	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
326424007842	Helix-Turn-Helix DNA binding domain of the BmrR transcription regulator; Region: HTH_BmrR; cd01107
326424007843	DNA binding residues [nucleotide binding]
326424007844	drug binding residues [chemical binding]; other site
326424007845	dimer interface [polypeptide binding]; other site
326424007846	GyrI-like small molecule binding domain; Region: GyrI-like; cl01368
326424007847	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
326424007848	S-adenosylmethionine binding site [chemical binding]; other site
326424007849	Helix-turn-helix domain; Region: HTH_18; pfam12833
326424007850	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
326424007851	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
326424007852	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
326424007853	S-adenosylmethionine binding site [chemical binding]; other site
326424007854	Helix-turn-helix domains; Region: HTH; cl00088
326424007855	RNA polymerase sigma factor SigJ; Provisional; Region: PRK09636
326424007856	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
326424007857	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761
326424007858	Protein of unknown function (DUF2599); Region: DUF2599; pfam10783
326424007859	CrcB-like protein; Region: CRCB; cl09114
326424007860	CrcB-like protein; Region: CRCB; cl09114
326424007861	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
326424007862	mttA/Hcf106 family; Region: MttA_Hcf106; cl00788
326424007863	Predicted dithiol-disulfide isomerase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FrnE; COG2761
326424007864	DsbA family, FrnE subfamily; FrnE is a DsbA-like protein containing a CXXC motif. It is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the aromatic antibiotics frenolicin and nanaomycins; Region: DsbA_FrnE; cd03024
326424007865	catalytic residues [active]
326424007866	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076
326424007867	amino acid transporter; Region: 2A0306; TIGR00909
326424007868	Spore germination protein; Region: Spore_permease; cl15802
326424007869	amino acid transporter; Region: 2A0306; TIGR00909
326424007870	Luciferase-like monooxygenase; Region: Bac_luciferase; pfam00296
326424007871	N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357
326424007872	Leucine carboxyl methyltransferase; Region: LCM; cl01306
326424007873	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
326424007874	DNA binding site [nucleotide binding]
326424007875	Int/Topo IB signature motif; other site
326424007876	active site
326424007877	TIR domain; Region: TIR_2; cl15770
326424007878	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200
326424007879	structural tetrad; other site
326424007880	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
326424007881	Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; cl15394
326424007882	Phosphotransferase enzyme family; Region: APH; pfam01636
326424007883	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
326424007884	cobaltochelatase subunit; Region: Cob-chelat-sub; TIGR02442
326424007885	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
326424007886	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057
326424007887	metal ion-dependent adhesion site (MIDAS); other site
326424007888	ATP:corrinoid adenosyltransferase [Coenzyme metabolism]; Region: BtuR; COG2109
326424007889	ATP:corrinoid adenosyltransferase BtuR/CobO/CobP. This family consists of the BtuR, CobO, CobP proteins all of which are Cob(I)alamin (vitamin B12) adenosyltransferase, which is involved in cobalamin (vitamin B12) biosynthesis. This enzyme is a homodimer; Region: CobA_CobO_BtuR; cd00561
326424007890	homodimer interface [polypeptide binding]; other site
326424007891	Walker A motif; other site
326424007892	ATP binding site [chemical binding]; other site
326424007893	hydroxycobalamin binding site [chemical binding]; other site
326424007894	Walker B motif; other site
326424007895	cobyrinic acid a,c-diamide synthase; Validated; Region: PRK01077
326424007896	Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020
326424007897	conserved cys residue [active]
326424007898	Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020
326424007899	Cobalamin synthesis G C-terminus; Region: CbiG_C; cl12133
326424007900	extended (e) SDRs; Region: SDR_e; cd08946
326424007901	NAD(P) binding site [chemical binding]; other site
326424007902	active site
326424007903	substrate binding site [chemical binding]; other site
326424007904	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
326424007905	Precorrin-8X methylmutase; Region: CbiC; pfam02570
326424007906	Precorrin isomerase [Coenzyme metabolism]; Region: CobH; cl00913
326424007907	YCII-related domain; Region: YCII; cl00999
326424007908	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
326424007909	dimerization interface [polypeptide binding]; other site
326424007910	putative DNA binding site [nucleotide binding]; other site
326424007911	putative Zn2+ binding site [ion binding]; other site
326424007912	ThiC family; Region: ThiC; cl08031
326424007913	Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086
326424007914	active site
326424007915	Epoxide hydrolase N terminus; Region: EHN; pfam06441
326424007916	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
326424007917	N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357
326424007918	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
326424007919	ABC transporter signature motif; other site
326424007920	Predicted transcriptional regulators [Transcription]; Region: COG1725
326424007921	Helix-turn-helix domains; Region: HTH; cl00088
326424007922	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
326424007923	DNA-binding site [nucleotide binding]; DNA binding site
326424007924	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
326424007925	This family of ATP-binding proteins belongs to a multisubunit transporter involved in drug resistance (BcrA and DrrA), nodulation, lipid transport, and lantibiotic immunity.  In bacteria and archaea, these transporters usually include an ATP-binding...; Region: ABC_DR_subfamily_A; cd03230
326424007926	Walker A/P-loop; other site
326424007927	ATP binding site [chemical binding]; other site
326424007928	Q-loop/lid; other site
326424007929	ABC transporter signature motif; other site
326424007930	Walker B; other site
326424007931	D-loop; other site
326424007932	H-loop/switch region; other site
326424007933	Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381
326424007934	Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381
326424007935	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
326424007936	active site
326424007937	ATP binding site [chemical binding]; other site
326424007938	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
326424007939	substrate binding site [chemical binding]; other site
326424007940	TM2 domain; Region: TM2; cl00984
326424007941	Uncharacterized protein family (UPF0157); Region: UPF0157; cl00987
326424007942	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
326424007943	putative acyl-acceptor binding pocket; other site
326424007944	Domain of unknown function (DUF2088); Region: DUF2088; cl15406
326424007945	fatty acyl-CoA reductase; Region: PLN02996
326424007946	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
326424007947	NAD(P) binding site [chemical binding]; other site
326424007948	active site
326424007949	C-terminal domain of fatty acyl CoA reductases; Region: FAR_C; cl03838
326424007950	Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560
326424007951	Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391
326424007952	PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859
326424007953	5'-3' exonuclease, N-terminal resolvase-like domain; Region: 5_3_exonuc_N; pfam02739
326424007954	active site
326424007955	putative 5' ssDNA interaction site; other site
326424007956	metal binding site 3; metal-binding site
326424007957	metal binding site 1 [ion binding]; metal-binding site
326424007958	metal binding site 2 [ion binding]; metal-binding site
326424007959	H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898
326424007960	putative DNA binding site [nucleotide binding]; other site
326424007961	putative metal binding site [ion binding]; other site
326424007962	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
326424007963	Helix-turn-helix domains; Region: HTH; cl00088
326424007964	glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650
326424007965	The N-terminal ATPase domain of the maltose transporter, MalK.  ATP binding cassette (ABC) proteins function from bacteria to human, mediating the translocation of substances into and out of cells or organelles.  ABC transporters contain two...; Region: ABC_MalK_N; cd03301
326424007966	Walker A/P-loop; other site
326424007967	ATP binding site [chemical binding]; other site
326424007968	Q-loop/lid; other site
326424007969	ABC transporter signature motif; other site
326424007970	Walker B; other site
326424007971	D-loop; other site
326424007972	H-loop/switch region; other site
326424007973	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
326424007974	dimer interface [polypeptide binding]; other site
326424007975	conserved gate region; other site
326424007976	putative PBP binding loops; other site
326424007977	ABC-ATPase subunit interface; other site
326424007978	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427
326424007979	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
326424007980	imidazolonepropionase; Validated; Region: PRK09356
326424007981	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
326424007982	active site
326424007983	Apolipoprotein N-acyltransferase [Cell envelope biogenesis, outer membrane]; Region: Lnt; COG0815
326424007984	Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571
326424007985	putative active site [active]
326424007986	catalytic triad [active]
326424007987	putative dimer interface [polypeptide binding]; other site
326424007988	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
326424007989	DPM1_like represents putative enzymes similar to eukaryotic DPM1; Region: DPM1_like; cd06442
326424007990	Ligand binding site; other site
326424007991	Putative Catalytic site; other site
326424007992	DXD motif; other site
326424007993	Domain of unknown function (DUF4109); Region: DUF4109; pfam13397
326424007994	methionine sulfoxide reductase B; Provisional; Region: PRK00222; cl15841
326424007995	SelR domain; Region: SelR; pfam01641
326424007996	Domain of unknown function (DUF4262); Region: DUF4262; pfam14081
326424007997	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
326424007998	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: APH_ChoK_like; cd05120
326424007999	active site
326424008000	ATP binding site [chemical binding]; other site
326424008001	substrate binding site [chemical binding]; other site
326424008002	Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226
326424008003	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
326424008004	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
326424008005	bifunctional 3'-5' exonuclease/DNA polymerase; Provisional; Region: PRK14975
326424008006	Family A polymerase primarily fills DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A; cl02626
326424008007	active site
326424008008	DNA binding site [nucleotide binding]
326424008009	catalytic site [active]
326424008010	The Delta9 Fatty Acid Desaturase (Delta9-FADS)-like CD includes the delta-9 and delta-11 acyl CoA desaturases found in various eukaryotes including vertebrates, insects, higher plants, and fungi. The delta-9 acyl-lipid desaturases are found in a wide...; Region: Delta9-FADS-like; cd03505
326424008011	Di-iron ligands [ion binding]; other site
326424008012	The Delta9 Fatty Acid Desaturase (Delta9-FADS)-like CD includes the delta-9 and delta-11 acyl CoA desaturases found in various eukaryotes including vertebrates, insects, higher plants, and fungi. The delta-9 acyl-lipid desaturases are found in a wide...; Region: Delta9-FADS-like; cd03505
326424008013	Superfamily II RNA helicase [DNA replication, recombination, and repair]; Region: COG4581
326424008014	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
326424008015	ATP binding site [chemical binding]; other site
326424008016	putative Mg++ binding site [ion binding]; other site
326424008017	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
326424008018	nucleotide binding region [chemical binding]; other site
326424008019	ATP-binding site [chemical binding]; other site
326424008020	Domain of unknown function (DUF3516); Region: DUF3516; pfam12029
326424008021	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
326424008022	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
326424008023	active site
326424008024	phosphorylation site [posttranslational modification]
326424008025	intermolecular recognition site; other site
326424008026	dimerization interface [polypeptide binding]; other site
326424008027	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
326424008028	DNA binding residues [nucleotide binding]
326424008029	dimerization interface [polypeptide binding]; other site
326424008030	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2187
326424008031	AAA domain; Region: AAA_33; pfam13671
326424008032	TM2 domain; Region: TM2; cl00984
326424008033	Protein of unknown function (DUF2752); Region: DUF2752; pfam10825
326424008034	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
326424008035	active site
326424008036	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
326424008037	active site
326424008038	Lipase (class 3).  Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface.  A typical feature of lipases is 'interfacial activation,' the process of...; Region: Lipase_3; cd00519
326424008039	active site flap/lid [active]
326424008040	nucleophilic elbow; other site
326424008041	catalytic triad [active]
326424008042	Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381
326424008043	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
326424008044	probable F420-dependent oxidoreductase, Rv2161c family; Region: F420_Rv2161c; TIGR03619
326424008045	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
326424008046	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557
326424008047	NAD(P) binding site [chemical binding]; other site
326424008048	active site
326424008049	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
326424008050	drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711
326424008051	XdhC Rossmann domain; Region: XdhC_C; pfam13478
326424008052	enoyl-CoA hydratase; Provisional; Region: PRK08252
326424008053	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
326424008054	substrate binding site [chemical binding]; other site
326424008055	oxyanion hole (OAH) forming residues; other site
326424008056	trimer interface [polypeptide binding]; other site
326424008057	Periplasmic binding protein; Region: Peripla_BP_6; pfam13458
326424008058	Type I periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type active transport systems that are predicted to be involved in transport of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_7; cd06341
326424008059	putative ligand binding site [chemical binding]; other site
326424008060	Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647
326424008061	Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647
326424008062	Sulfotransferase domain; Region: Sulfotransfer_1; pfam00685
326424008063	Uncharacterized protein conserved in bacteria (DUF2237); Region: DUF2237; cl01467
326424008064	Superfamily I DNA and RNA helicases [General function prediction only]; Region: COG3973
326424008065	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
326424008066	Superfamily I DNA and RNA helicases [General function prediction only]; Region: COG3973
326424008067	Family description; Region: UvrD_C_2; cl15862
326424008068	Helix-turn-helix domains; Region: HTH; cl00088
326424008069	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
326424008070	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
326424008071	RNA binding domain of NusB (N protein-Utilization Substance B) and Sun (also known as RrmB or Fmu) proteins. This family includes two orthologous groups exemplified by the transcription termination factor NusB and the N-terminal domain of the...; Region: NusB_Sun; cl00223
326424008072	Type I periplasmic ligand-binding domain of uncharacterized ABC-type transport systems that are predicted to be involved in the uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_uncharacterized_transporter; cd06325
326424008073	zinc binding site [ion binding]; other site
326424008074	putative ligand binding site [chemical binding]; other site
326424008075	Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cd06574
326424008076	TM-ABC transporter signature motif; other site
326424008077	ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: PhnK; COG1101
326424008078	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
326424008079	Walker A/P-loop; other site
326424008080	ATP binding site [chemical binding]; other site
326424008081	Q-loop/lid; other site
326424008082	ABC transporter signature motif; other site
326424008083	Walker B; other site
326424008084	D-loop; other site
326424008085	H-loop/switch region; other site
326424008086	Family of homologous FMN-dependent alpha-hydroxyacid oxidizing enzymes. This family occurs in both prokaryotes and eukaryotes. Members of this family include flavocytochrome b2 (FCB2), glycolate oxidase (GOX), lactate monooxygenase (LMO), mandelate...; Region: alpha_hydroxyacid_oxid_FMN; cd02809
326424008087	FMN-dependent dehydrogenase; Region: FMN_dh; pfam01070
326424008088	active site
326424008089	substrate binding site [chemical binding]; other site
326424008090	FMN binding site [chemical binding]; other site
326424008091	putative catalytic residues [active]
326424008092	YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448
326424008093	homotrimer interaction site [polypeptide binding]; other site
326424008094	putative active site [active]
326424008095	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
326424008096	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587
326424008097	active site
326424008098	Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719
326424008099	Zn binding sites [ion binding]; other site
326424008100	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
326424008101	NADH(P)-binding; Region: NAD_binding_10; pfam13460
326424008102	heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386
326424008103	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
326424008104	phosphorylation site [posttranslational modification]
326424008105	dimer interface [polypeptide binding]; other site
326424008106	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
326424008107	ATP binding site [chemical binding]; other site
326424008108	Mg2+ binding site [ion binding]; other site
326424008109	G-X-G motif; other site
326424008110	heavy metal response regulator; Region: cztR_silR_copR; TIGR01387
326424008111	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
326424008112	active site
326424008113	phosphorylation site [posttranslational modification]
326424008114	intermolecular recognition site; other site
326424008115	dimerization interface [polypeptide binding]; other site
326424008116	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
326424008117	DNA binding site [nucleotide binding]
326424008118	drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711
326424008119	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
326424008120	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
326424008121	Helix-turn-helix domains; Region: HTH; cl00088
326424008122	AefR-like transcriptional repressor, C-terminal region; Region: TetR_C_7; pfam14246
326424008123	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
326424008124	4Fe-4S single cluster domain; Region: Fer4_15; pfam13459
326424008125	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; cl12078
326424008126	urea ABC transporter, ATP-binding protein UrtE; Region: urea_trans_UrtE; TIGR03410
326424008127	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
326424008128	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411
326424008129	The Mj1267/LivG ABC transporter subfamily is involved in the transport of the hydrophobic amino acids leucine, isoleucine and valine.  MJ1267 is a branched-chain amino acid transporter with 29% similarity to both the LivF and LivG components of the E; Region: ABC_Mj1267_LivG_branched; cd03219
326424008130	Walker A/P-loop; other site
326424008131	ATP binding site [chemical binding]; other site
326424008132	Q-loop/lid; other site
326424008133	ABC transporter signature motif; other site
326424008134	Walker B; other site
326424008135	D-loop; other site
326424008136	H-loop/switch region; other site
326424008137	Periplasmic binding protein; Region: Peripla_BP_6; pfam13458
326424008138	Type I periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type active transport systems that are predicted to be involved in transport of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_7; cd06341
326424008139	putative ligand binding site [chemical binding]; other site
326424008140	Flavin Reductases; Region: FlaRed; cl00801
326424008141	Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531
326424008142	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
326424008143	Leucine carboxyl methyltransferase; Region: LCM; cl01306
326424008144	Putative neutral zinc metallopeptidase; Region: Zn_peptidase; cl00988
326424008145	RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278
326424008146	RNA/DNA hybrid binding site [nucleotide binding]; other site
326424008147	active site
326424008148	Peptidase family M48; Region: Peptidase_M48; cl12018
326424008149	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
326424008150	Helix-turn-helix domains; Region: HTH; cl00088
326424008151	Predicted nucleic-acid-binding protein containing a Zn-ribbon [General function prediction only]; Region: COG1545
326424008152	Rubredoxin-like zinc ribbon domain (DUF35_N); Region: DUF35_N; pfam12172
326424008153	DUF35 OB-fold domain; Region: DUF35; pfam01796
326424008154	lipid-transfer protein; Provisional; Region: PRK08256
326424008155	Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2  has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829
326424008156	active site
326424008157	Helix-turn-helix domains; Region: HTH; cl00088
326424008158	oxidoreductase; Provisional; Region: PRK06196
326424008159	retinol dehydrogenase (retinol-DH), Light dependent Protochlorophyllide (Pchlide) OxidoReductase (LPOR) and related proteins, classical (c) SDRs; Region: retinol-DH_like_SDR_c_like; cd05327
326424008160	putative NAD(P) binding site [chemical binding]; other site
326424008161	active site
326424008162	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
326424008163	Catalytic domain of Protein Kinases; Region: PKc; cd00180
326424008164	active site
326424008165	ATP binding site [chemical binding]; other site
326424008166	substrate binding site [chemical binding]; other site
326424008167	activation loop (A-loop); other site
326424008168	PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577
326424008169	PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577
326424008170	Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064
326424008171	Cinnamyl alcohol dehydrogenases (CAD); Region: CAD1; cd05283
326424008172	putative NAD(P) binding site [chemical binding]; other site
326424008173	putative substrate binding site [chemical binding]; other site
326424008174	catalytic Zn binding site [ion binding]; other site
326424008175	structural Zn binding site [ion binding]; other site
326424008176	dimer interface [polypeptide binding]; other site
326424008177	[FeFe] hydrogenase, group B1/B3; Region: FeFe_hydrog_B1; TIGR04105
326424008178	4Fe-4S binding domain; Region: Fer4; cl02805
326424008179	Uncharacterized anaerobic dehydrogenase [General function prediction only]; Region: COG3383
326424008180	Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409
326424008181	Carboxyl transferase domain; Region: Carboxyl_trans; pfam01039
326424008182	Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl15772
326424008183	Predicted thioesterase involved in non-ribosomal peptide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: GrsT; COG3208
326424008184	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
326424008185	Transmembrane secretion effector; Region: MFS_3; pfam05977
326424008186	FAD binding domain; Region: FAD_binding_4; pfam01565
326424008187	glycolate oxidase, subunit GlcD; Region: glcD; TIGR00387
326424008188	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
326424008189	Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546
326424008190	Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897
326424008191	Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448
326424008192	active site residue [active]
326424008193	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125
326424008194	active site residue [active]
326424008195	ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123
326424008196	The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE).  The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257
326424008197	Walker A/P-loop; other site
326424008198	ATP binding site [chemical binding]; other site
326424008199	Q-loop/lid; other site
326424008200	ABC transporter signature motif; other site
326424008201	Walker B; other site
326424008202	D-loop; other site
326424008203	H-loop/switch region; other site
326424008204	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
326424008205	The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE).  The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257
326424008206	Walker A/P-loop; other site
326424008207	ATP binding site [chemical binding]; other site
326424008208	Q-loop/lid; other site
326424008209	ABC transporter signature motif; other site
326424008210	Walker B; other site
326424008211	D-loop; other site
326424008212	H-loop/switch region; other site
326424008213	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
326424008214	dimer interface [polypeptide binding]; other site
326424008215	conserved gate region; other site
326424008216	putative PBP binding loops; other site
326424008217	ABC-ATPase subunit interface; other site
326424008218	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
326424008219	dimer interface [polypeptide binding]; other site
326424008220	conserved gate region; other site
326424008221	ABC-ATPase subunit interface; other site
326424008222	The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_15; cd08492
326424008223	Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496
326424008224	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
326424008225	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
326424008226	active site
326424008227	alkanesulfonate monooxygenase, FMNH(2)-dependent; Region: alk_sulf_monoox; TIGR03565
326424008228	Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094
326424008229	dimer interface [polypeptide binding]; other site
326424008230	active site
326424008231	non-prolyl cis peptide bond; other site
326424008232	insertion regions; other site
326424008233	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
326424008234	Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695
326424008235	Helix-turn-helix domains; Region: HTH; cl00088
326424008236	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
326424008237	dimerization interface [polypeptide binding]; other site
326424008238	GAF domain; Region: GAF_2; pfam13185
326424008239	GAF domain; Region: GAF; cl15785
326424008240	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
326424008241	large tegument protein UL36; Provisional; Region: PHA03247
326424008242	Helix-turn-helix domains; Region: HTH; cl00088
326424008243	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
326424008244	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
326424008245	active site
326424008246	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
326424008247	active site
326424008248	ATP binding site [chemical binding]; other site
326424008249	Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804
326424008250	CoA-transferase family III; Region: CoA_transf_3; pfam02515
326424008251	Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804
326424008252	CoA-transferase family III; Region: CoA_transf_3; pfam02515
326424008253	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
326424008254	active site
326424008255	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
326424008256	Acyl-CoA dehydrogenase; Region: ACAD; cd00567
326424008257	active site
326424008258	Helix-turn-helix domains; Region: HTH; cl00088
326424008259	Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909
326424008260	High-affinity nickel-transport protein; Region: NicO; cl00964
326424008261	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
326424008262	EamA-like transporter family; Region: EamA; cl01037
326424008263	EamA-like transporter family; Region: EamA; cl01037
326424008264	hypothetical protein; Provisional; Region: PRK06815
326424008265	Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342
326424008266	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
326424008267	catalytic residue [active]
326424008268	Phosphotransferase enzyme family; Region: APH; pfam01636
326424008269	Fatty acid desaturase; Region: FA_desaturase; pfam00487
326424008270	The Delta6 Fatty Acid Desaturase (Delta6-FADS)-like CD includes the integral-membrane enzymes: delta-4, delta-5, delta-6, delta-8, delta-8-sphingolipid, and delta-11 desaturases found in vertebrates, higher plants, fungi, and bacteria. These desaturases...; Region: Delta6-FADS-like; cd03506
326424008271	putative di-iron ligands [ion binding]; other site
326424008272	GAF domain; Region: GAF; cl15785
326424008273	ANTAR domain; Region: ANTAR; cl04297
326424008274	ANTAR domain; Region: ANTAR; cl04297
326424008275	Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043
326424008276	anti sigma factor interaction site; other site
326424008277	regulatory phosphorylation site [posttranslational modification]; other site
326424008278	Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753
326424008279	Catalase-like heme-binding proteins and protein domains; Region: catalase_like; cl09506
326424008280	heme binding pocket [chemical binding]; other site
326424008281	Type 1 glutamine amidotransferase (GATase1)-like domain found in at the C-terminal of several large catalases; Region: GATase1_catalase; cd03132
326424008282	domain interactions; other site
326424008283	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
326424008284	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
326424008285	substrate binding pocket [chemical binding]; other site
326424008286	membrane-bound complex binding site; other site
326424008287	hinge residues; other site
326424008288	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
326424008289	Catalytic domain of Protein Kinases; Region: PKc; cd00180
326424008290	active site
326424008291	ATP binding site [chemical binding]; other site
326424008292	substrate binding site [chemical binding]; other site
326424008293	activation loop (A-loop); other site
326424008294	Tetratricopeptide repeat; Region: TPR_16; pfam13432
326424008295	putative PEP-CTERM system TPR-repeat lipoprotein; Region: PEP_TPR_lipo; TIGR02917
326424008296	Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cl00120
326424008297	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057
326424008298	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
326424008299	phosphopeptide binding site; other site
326424008300	TIR domain; Region: TIR_2; cl15770
326424008301	Tetratricopeptide repeat; Region: TPR_10; pfam13374
326424008302	Predicted transcriptional regulator [Transcription]; Region: COG2378
326424008303	Helix-turn-helix domains; Region: HTH; cl00088
326424008304	WYL domain; Region: WYL; cl14852
326424008305	Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233
326424008306	Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233
326424008307	Transcription factor WhiB; Region: Whib; pfam02467
326424008308	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
326424008309	DNA binding site [nucleotide binding]
326424008310	Int/Topo IB signature motif; other site
326424008311	active site
326424008312	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075
326424008313	GAF domain; Region: GAF_2; pfam13185
326424008314	Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cl00120
326424008315	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
326424008316	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
326424008317	Walker A/P-loop; other site
326424008318	ATP binding site [chemical binding]; other site
326424008319	Q-loop/lid; other site
326424008320	ABC transporter signature motif; other site
326424008321	Walker B; other site
326424008322	D-loop; other site
326424008323	H-loop/switch region; other site
326424008324	ABC-2 family transporter protein; Region: ABC2_membrane_6; cl01496
326424008325	ABC-2 family transporter protein; Region: ABC2_membrane_6; cl01496
326424008326	ABC-2 family transporter protein; Region: ABC2_membrane_6; cl01496
326424008327	N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357
326424008328	S-adenosyl methyltransferase; Region: Methyltransf_19; pfam04672
326424008329	Phosphorylase superfamily; Region: PNP_UDP_1; cl00303
326424008330	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447
326424008331	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447
326424008332	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808
326424008333	S-adenosyl methyltransferase; Region: Methyltransf_19; pfam04672
326424008334	START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643
326424008335	hydrophobic ligand binding site; other site
326424008336	Uncharacterized protein conserved in bacteria (DUF2236); Region: DUF2236; cl01472
326424008337	Uncharacterized conserved protein (DUF2277); Region: DUF2277; cl02349
326424008338	GAF domain; Region: GAF; cl15785
326424008339	GAF domain; Region: GAF_2; pfam13185
326424008340	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
326424008341	MMPL family; Region: MMPL; pfam03176
326424008342	Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409
326424008343	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; cl12078
326424008344	drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711
326424008345	Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581
326424008346	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
326424008347	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
326424008348	active site
326424008349	ADP-heptose synthase, bifunctional sugar kinase/adenylyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaE; COG2870
326424008350	ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192
326424008351	substrate binding site [chemical binding]; other site
326424008352	ATP binding site [chemical binding]; other site
326424008353	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
326424008354	active site
326424008355	nucleotide binding site [chemical binding]; other site
326424008356	HIGH motif; other site
326424008357	KMSKS motif; other site
326424008358	Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789
326424008359	Glycosyltransferase family 9 (heptosyltransferase); Region: Glyco_transf_9; pfam01075
326424008360	putative active site [active]
326424008361	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
326424008362	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
326424008363	HAD-superfamily hydrolase, subfamily IIIA; Region: HAD-SF-IIIA; TIGR01662
326424008364	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
326424008365	active site
326424008366	motif I; other site
326424008367	motif II; other site
326424008368	ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859
326424008369	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
326424008370	Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789
326424008371	putative active site [active]
326424008372	UDP-N-acetylglucosamine: 1L-myo-inositol-1-phosphate 1-alpha-D-N-acetylglucosaminyltransferase; Region: mycothiol_MshA; TIGR03449
326424008373	This family is most closely related to the GT1 family of glycosyltransferases. The sucrose-phosphate synthases in this family may be unique to plants and photosynthetic bacteria. This enzyme catalyzes the synthesis of sucrose 6-phosphate from fructose...; Region: GT1_Sucrose_synthase; cd03800
326424008374	putative ADP-binding pocket [chemical binding]; other site
326424008375	Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006
326424008376	dimer interface [polypeptide binding]; other site
326424008377	active site
326424008378	ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192
326424008379	ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192
326424008380	ATP binding site [chemical binding]; other site
326424008381	Cytidylyltransferase; Region: CTP_transf_2; pfam01467
326424008382	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
326424008383	active site
326424008384	HIGH motif; other site
326424008385	nucleotide binding site [chemical binding]; other site
326424008386	classical (c) SDRs; Region: SDR_c; cd05233
326424008387	NAD(P) binding site [chemical binding]; other site
326424008388	active site
326424008389	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
326424008390	TIR domain; Region: TIR_2; cl15770
326424008391	YheO-like PAS domain; Region: PAS_6; pfam08348
326424008392	Protein of unknown function (DUF2795); Region: DUF2795; pfam11387
326424008393	FOG: CBS domain [General function prediction only]; Region: COG0517
326424008394	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_9; cd04622
326424008395	drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711
326424008396	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
326424008397	putative substrate translocation pore; other site
326424008398	Helix-turn-helix domains; Region: HTH; cl00088
326424008399	PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474
326424008400	active site
326424008401	PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474
326424008402	Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; some contain an N-terminal GntR family winged HTH DNA-binding domain; Region: SRPBCC_CalC_Aha1-like_GntR-HTH; cd08893
326424008403	putative hydrophobic ligand binding site [chemical binding]; other site
326424008404	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: APH_ChoK_like; cd05120
326424008405	active site
326424008406	ATP binding site [chemical binding]; other site
326424008407	substrate binding site [chemical binding]; other site
326424008408	ApbE family; Region: ApbE; cl00643
326424008409	Ferric reductase like transmembrane component; Region: Ferric_reduct; cl01043
326424008410	Respiratory-chain NADH dehydrogenase 51 Kd subunit; Region: Complex1_51K; pfam01512
326424008411	NADH-quinone oxidoreductase, F subunit; Region: nuoF_fam; TIGR01959
326424008412	NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; cl11211
326424008413	4Fe-4S single cluster domain; Region: Fer4_15; pfam13459
326424008414	Domain of unknown function (DUF4190); Region: DUF4190; pfam13828
326424008415	TIR domain; Region: TIR_2; cl15770
326424008416	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
326424008417	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567
326424008418	structural tetrad; other site
326424008419	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567
326424008420	structural tetrad; other site
326424008421	classical (c) SDRs; Region: SDR_c; cd05233
326424008422	NAD(P) binding site [chemical binding]; other site
326424008423	active site
326424008424	Helix-turn-helix domains; Region: HTH; cl00088
326424008425	PhoD-like phosphatase; Region: PhoD; pfam09423
326424008426	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
326424008427	active site
326424008428	metal binding site [ion binding]; metal-binding site
326424008429	Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149
326424008430	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
326424008431	protein binding site [polypeptide binding]; other site
326424008432	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
326424008433	Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174
326424008434	substrate binding site [chemical binding]; other site
326424008435	dimer interface [polypeptide binding]; other site
326424008436	ATP binding site [chemical binding]; other site
326424008437	probable F420-dependent oxidoreductase, Rv2161c family; Region: F420_Rv2161c; TIGR03619
326424008438	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
326424008439	Predicted methyltransferase [General function prediction only]; Region: COG2520
326424008440	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
326424008441	Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024
326424008442	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
326424008443	substrate binding site [chemical binding]; other site
326424008444	oxyanion hole (OAH) forming residues; other site
326424008445	trimer interface [polypeptide binding]; other site
326424008446	Luciferase-like monooxygenase; Region: Bac_luciferase; pfam00296
326424008447	N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097
326424008448	PaaX-like protein C-terminal domain; Region: PaaX_C; pfam08223
326424008449	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
326424008450	NAD(P) binding site [chemical binding]; other site
326424008451	classical (c) SDRs; Region: SDR_c; cd05233
326424008452	active site
326424008453	Predicted oxidoreductases (related to aryl-alcohol dehydrogenases) [Energy production and conversion]; Region: Tas; COG0667
326424008454	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
326424008455	active site
326424008456	catalytic tetrad [active]
326424008457	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
326424008458	acetyl-CoA acetyltransferases; Region: AcCoA-C-Actrans; TIGR01930
326424008459	dimer interface [polypeptide binding]; other site
326424008460	active site
326424008461	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
326424008462	3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830
326424008463	NAD(P) binding site [chemical binding]; other site
326424008464	active site
326424008465	Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446
326424008466	Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771
326424008467	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
326424008468	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
326424008469	pimeloyl-CoA dehydrogenase, large subunit; Region: pimC_large; TIGR03204
326424008470	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
326424008471	active site
326424008472	Helix-turn-helix domains; Region: HTH; cl00088
326424008473	tetracycline repressor protein TetR; Provisional; Region: PRK13756
326424008474	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
326424008475	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
326424008476	active site
326424008477	metal binding site [ion binding]; metal-binding site
326424008478	Periplasmic binding protein TroA_e.  These proteins are predicted to function as initial receptors in the ABC metal ion uptake in eubacteria and archaea.  They belong to the TroA superfamily of helical backbone metal receptor proteins that share a...; Region: TroA_e; cd01142
326424008479	putative ligand binding residues [chemical binding]; other site
326424008480	Periplasmic binding protein; Region: Peripla_BP_2; pfam01497
326424008481	Excalibur calcium-binding domain; Region: Excalibur; cl05460
326424008482	Excalibur calcium-binding domain; Region: Excalibur; cl05460
326424008483	Excalibur calcium-binding domain; Region: Excalibur; cl05460
326424008484	PhosphatidylEthanolamine-Binding Protein (PEBP) domain; Region: PEBP; cl00227
326424008485	Helix-turn-helix domains; Region: HTH; cl00088
326424008486	FCD domain; Region: FCD; cl11656
326424008487	heat shock protein 90; Provisional; Region: PRK05218
326424008488	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
326424008489	ATP binding site [chemical binding]; other site
326424008490	Mg2+ binding site [ion binding]; other site
326424008491	G-X-G motif; other site
326424008492	TIR domain; Region: TIR_2; cl15770
326424008493	Tetratricopeptide repeat; Region: TPR_10; pfam13374
326424008494	Plant protein of unknown function (DUF946); Region: DUF946; pfam06101
326424008495	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
326424008496	active site
326424008497	Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl15769
326424008498	Helix-turn-helix domains; Region: HTH; cl00088
326424008499	Protein of unknown function (DUF2889); Region: DUF2889; pfam11136
326424008500	similar to hypothetical protein; Evidence 6 : Doubtful CDS
326424008501	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
326424008502	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
326424008503	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
326424008504	putative substrate translocation pore; other site
326424008505	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
326424008506	putative substrate translocation pore; other site
326424008507	Domain of unknown function (DUF222); Region: DUF222; pfam02720
326424008508	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
326424008509	active site
326424008510	Putative NADP-dependent oxidoreductases [General function prediction only]; Region: COG2130
326424008511	Prostaglandin dehydrogenases; Region: PGDH; cd05288
326424008512	NAD(P) binding site [chemical binding]; other site
326424008513	substrate binding site [chemical binding]; other site
326424008514	dimer interface [polypeptide binding]; other site
326424008515	DinB superfamily; Region: DinB_2; pfam12867
326424008516	Phosphorylase superfamily; Region: PNP_UDP_1; cl00303
326424008517	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
326424008518	Helix-turn-helix domains; Region: HTH; cl00088
326424008519	biliverdin IX beta reductase (BVR-B, aka flavin reductase)-like proteins; atypical (a) SDRs; Region: BVR-B_like_SDR_a; cd05244
326424008520	NADH(P)-binding; Region: NAD_binding_10; pfam13460
326424008521	NAD binding site [chemical binding]; other site
326424008522	substrate binding site [chemical binding]; other site
326424008523	putative active site [active]
326424008524	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
326424008525	Helix-turn-helix domains; Region: HTH; cl00088
326424008526	WHG domain; Region: WHG; pfam13305
326424008527	phenylpropionate dioxygenase ferredoxin reductase subunit; Provisional; Region: PRK09754
326424008528	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
326424008529	Merozoite surface protein 1 (MSP1) C-terminus; Region: MSP1_C; pfam07462
326424008530	3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084
326424008531	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
326424008532	Carboxymuconolactone decarboxylase family; Region: CMD; cl00460
326424008533	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; cl12078
326424008534	The enzymes of glycosyl hydrolase family 31 (GH31) occur in prokaryotes, eukaryotes, and archaea with a wide range of hydrolytic activities, including alpha-glucosidase (glucoamylase and sucrase-isomaltase), alpha-xylosidase, 6-alpha-glucosyltransferase; Region: GH31; cl11402
326424008535	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
326424008536	ATP-dependent helicase HrpB; Region: DEAH_box_HrpB; TIGR01970
326424008537	ATP binding site [chemical binding]; other site
326424008538	putative Mg++ binding site [ion binding]; other site
326424008539	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
326424008540	ATP-dependent helicase HrpB; Region: DEAH_box_HrpB; TIGR01970
326424008541	ATP-dependent helicase C-terminal; Region: HrpB_C; pfam08482
326424008542	Uncharacterized conserved protein [Function unknown]; Region: COG2128
326424008543	Carboxymuconolactone decarboxylase family; Region: CMD; cl00460
326424008544	RNA polymerase sigma factor SigJ; Provisional; Region: PRK09636
326424008545	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
326424008546	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761
326424008547	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
326424008548	Catalytic domain of Protein Kinases; Region: PKc; cd00180
326424008549	active site
326424008550	ATP binding site [chemical binding]; other site
326424008551	substrate binding site [chemical binding]; other site
326424008552	activation loop (A-loop); other site
326424008553	PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577
326424008554	PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577
326424008555	PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577
326424008556	Sigma factor PP2C-like phosphatases; Region: PP2C_SIG; smart00331
326424008557	Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cl00120
326424008558	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
326424008559	Catalytic domain of Protein Kinases; Region: PKc; cd00180
326424008560	active site
326424008561	ATP binding site [chemical binding]; other site
326424008562	substrate binding site [chemical binding]; other site
326424008563	activation loop (A-loop); other site
326424008564	Predicted ATPase [General function prediction only]; Region: COG3899
326424008565	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
326424008566	GAF domain; Region: GAF_2; pfam13185
326424008567	GAF domain; Region: GAF; cl15785
326424008568	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
326424008569	metal binding site [ion binding]; metal-binding site
326424008570	active site
326424008571	I-site; other site
326424008572	Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141
326424008573	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
326424008574	Domain of unknown function (DUF385); Region: DUF385; cl04387
326424008575	3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565
326424008576	classical (c) SDRs; Region: SDR_c; cd05233
326424008577	NAD(P) binding site [chemical binding]; other site
326424008578	active site
326424008579	Uncharacterized conserved protein related to dihydrodipicolinate reductase [Function unknown]; Region: COG3804
326424008580	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
326424008581	DsbA family, FrnE subfamily; FrnE is a DsbA-like protein containing a CXXC motif. It is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the aromatic antibiotics frenolicin and nanaomycins; Region: DsbA_FrnE; cd03024
326424008582	Predicted dithiol-disulfide isomerase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FrnE; COG2761
326424008583	catalytic residues [active]
326424008584	Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain  (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464
326424008585	putative dimer interface [polypeptide binding]; other site
326424008586	Helix-Turn-Helix DNA binding domain of the HspR transcription regulator; Region: HTH_HspR; cd04766
326424008587	DNA binding residues [nucleotide binding]
326424008588	putative dimer interface [polypeptide binding]; other site
326424008589	Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064
326424008590	6-hydroxycyclohex-1-ene-1-carboxyl-CoA dehydrogenase, N-benzyl-3-pyrrolidinol dehydrogenase, and other MDR family members; Region: hydroxyacyl_CoA_DH; cd08254
326424008591	putative NAD(P) binding site [chemical binding]; other site
326424008592	catalytic Zn binding site [ion binding]; other site
326424008593	short chain dehydrogenase; Provisional; Region: PRK07774
326424008594	classical (c) SDRs; Region: SDR_c; cd05233
326424008595	NAD(P) binding site [chemical binding]; other site
326424008596	active site
326424008597	S-adenosyl methyltransferase; Region: Methyltransf_19; pfam04672
326424008598	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
326424008599	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
326424008600	active site
326424008601	Transcriptional regulator [Transcription]; Region: LysR; COG0583
326424008602	Helix-turn-helix domains; Region: HTH; cl00088
326424008603	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
326424008604	dimerization interface [polypeptide binding]; other site
326424008605	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
326424008606	active site
326424008607	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
326424008608	Rieske non-heme iron oxygenase (RO) family, Rieske ferredoxin component; composed of the Rieske ferredoxin component of some three-component RO systems including biphenyl dioxygenase (BPDO) and carbazole 1,9a-dioxygenase (CARDO). The RO family comprise a...; Region: Rieske_RO_ferredoxin; cd03528
326424008609	[2Fe-2S] cluster binding site [ion binding]; other site
326424008610	A new structural DNA glycosylase containing HEAT-like repeats; Region: AlkD_like_1; cd07064
326424008611	DNA alkylation repair enzyme; Region: DNA_alkylation; pfam08713
326424008612	active site
326424008613	Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_7; cd07825
326424008614	putative hydrophobic ligand binding site [chemical binding]; other site
326424008615	Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403
326424008616	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
326424008617	dimerization interface [polypeptide binding]; other site
326424008618	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
326424008619	dimer interface [polypeptide binding]; other site
326424008620	phosphorylation site [posttranslational modification]
326424008621	osmolarity sensor protein; Provisional; Region: envZ; PRK09467
326424008622	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
326424008623	G-X-G motif; other site
326424008624	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
326424008625	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
326424008626	active site
326424008627	phosphorylation site [posttranslational modification]
326424008628	intermolecular recognition site; other site
326424008629	dimerization interface [polypeptide binding]; other site
326424008630	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
326424008631	DNA binding site [nucleotide binding]
326424008632	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
326424008633	Major Facilitator Superfamily; Region: MFS_1; pfam07690
326424008634	putative substrate translocation pore; other site
326424008635	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
326424008636	GAF domain; Region: GAF; cl15785
326424008637	GAF domain; Region: GAF_2; pfam13185
326424008638	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
326424008639	Tannase and feruloyl esterase; Region: Tannase; pfam07519
326424008640	Tannase and feruloyl esterase; Region: Tannase; pfam07519
326424008641	polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cd00146
326424008642	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
326424008643	classical (c) SDRs; Region: SDR_c; cd05233
326424008644	NAD(P) binding site [chemical binding]; other site
326424008645	active site
326424008646	Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175
326424008647	Clavaminic acid synthetase (CAS) -like;  CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cl00184
326424008648	active site
326424008649	iron coordination sites [ion binding]; other site
326424008650	substrate binding pocket [chemical binding]; other site
326424008651	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557
326424008652	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
326424008653	NAD(P) binding site [chemical binding]; other site
326424008654	active site
326424008655	Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cl00214
326424008656	intersubunit interface [polypeptide binding]; other site
326424008657	active site
326424008658	Zn2+ binding site [ion binding]; other site
326424008659	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
326424008660	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
326424008661	Phosphotransferase enzyme family; Region: APH; pfam01636
326424008662	active site
326424008663	ATP binding site [chemical binding]; other site
326424008664	S-adenosyl methyltransferase; Region: Methyltransf_19; pfam04672
326424008665	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
326424008666	S-adenosylmethionine binding site [chemical binding]; other site
326424008667	Periplasmic binding protein; Region: Peripla_BP_6; pfam13458
326424008668	Type I periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type active transport systems that are predicted to be involved in transport of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_7; cd06341
326424008669	putative ligand binding site [chemical binding]; other site
326424008670	Predicted enzyme involved in methoxymalonyl-ACP biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FkbH; COG3882
326424008671	Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391
326424008672	Erythronolide synthase docking; Region: Docking; pfam08990
326424008673	polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833
326424008674	Beta-ketoacyl synthase; Region: PKS_KS; smart00825
326424008675	active site
326424008676	malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128
326424008677	Acyl transferase domain; Region: Acyl_transf_1; cl08282
326424008678	Phosphopantetheine attachment site; Region: PP-binding; cl09936
326424008679	Erythronolide synthase docking; Region: Docking; pfam08990
326424008680	Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321
326424008681	polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833
326424008682	active site
326424008683	Acyl transferase domain; Region: Acyl_transf_1; cl08282
326424008684	Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826
326424008685	Phosphopantetheine attachment site; Region: PP-binding; cl09936
326424008686	Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321
326424008687	polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833
326424008688	active site
326424008689	Acyl transferase domain; Region: Acyl_transf_1; cl08282
326424008690	Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826
326424008691	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
326424008692	enoyl reductase of polyketide synthase; Region: enoyl_red; cd05195
326424008693	Enoylreductase; Region: PKS_ER; smart00829
326424008694	NAD(P) binding site [chemical binding]; other site
326424008695	beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 3, complex (x); Region: KR_3_FAS_SDR_x; cd08956
326424008696	putative NADP binding site [chemical binding]; other site
326424008697	active site
326424008698	Phosphopantetheine attachment site; Region: PP-binding; cl09936
326424008699	polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833
326424008700	Beta-ketoacyl synthase; Region: PKS_KS; smart00825
326424008701	active site
326424008702	Acyl transferase domain; Region: Acyl_transf_1; cl08282
326424008703	malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128
326424008704	Phosphopantetheine attachment site; Region: PP-binding; cl09936
326424008705	Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321
326424008706	polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833
326424008707	active site
326424008708	Acyl transferase domain; Region: Acyl_transf_1; cl08282
326424008709	Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826
326424008710	beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 3, complex (x); Region: KR_3_FAS_SDR_x; cd08956
326424008711	putative NADP binding site [chemical binding]; other site
326424008712	active site
326424008713	Phosphopantetheine attachment site; Region: PP-binding; cl09936
326424008714	Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321
326424008715	polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833
326424008716	active site
326424008717	Acyl transferase domain; Region: Acyl_transf_1; cl08282
326424008718	Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826
326424008719	beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 3, complex (x); Region: KR_3_FAS_SDR_x; cd08956
326424008720	putative NADP binding site [chemical binding]; other site
326424008721	active site
326424008722	Phosphopantetheine attachment site; Region: PP-binding; cl09936
326424008723	Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321
326424008724	polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833
326424008725	active site
326424008726	Acyl transferase domain; Region: Acyl_transf_1; cl08282
326424008727	Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826
326424008728	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
326424008729	beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 3, complex (x); Region: KR_3_FAS_SDR_x; cd08956
326424008730	putative NADP binding site [chemical binding]; other site
326424008731	active site
326424008732	Phosphopantetheine attachment site; Region: PP-binding; cl09936
326424008733	Predicted thioesterase involved in non-ribosomal peptide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: GrsT; COG3208
326424008734	Alpha/beta hydrolase of unknown function (DUF1100); Region: DUF1100; pfam06500
326424008735	2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; cl02008
326424008736	3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK06816
326424008737	Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938
326424008738	active site
326424008739	Helix-turn-helix domains; Region: HTH; cl00088
326424008740	Bacterial transcriptional activator domain; Region: BTAD; pfam03704
326424008741	Predicted ATPase [General function prediction only]; Region: COG3899
326424008742	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
326424008743	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
326424008744	DNA binding residues [nucleotide binding]
326424008745	dimerization interface [polypeptide binding]; other site
326424008746	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
326424008747	active site
326424008748	catalytic tetrad [active]
326424008749	Protein of unknown function (DUF1271); Region: DUF1271; cl01443
326424008750	4Fe-4S single cluster domain; Region: Fer4_15; pfam13459
326424008751	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; cl12078
326424008752	ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123
326424008753	The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE).  The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257
326424008754	Walker A/P-loop; other site
326424008755	ATP binding site [chemical binding]; other site
326424008756	Q-loop/lid; other site
326424008757	ABC transporter signature motif; other site
326424008758	Walker B; other site
326424008759	D-loop; other site
326424008760	H-loop/switch region; other site
326424008761	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
326424008762	The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE).  The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257
326424008763	Walker A/P-loop; other site
326424008764	ATP binding site [chemical binding]; other site
326424008765	Q-loop/lid; other site
326424008766	ABC transporter signature motif; other site
326424008767	Walker B; other site
326424008768	D-loop; other site
326424008769	H-loop/switch region; other site
326424008770	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
326424008771	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173
326424008772	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
326424008773	putative PBP binding loops; other site
326424008774	ABC-ATPase subunit interface; other site
326424008775	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
326424008776	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
326424008777	dimer interface [polypeptide binding]; other site
326424008778	conserved gate region; other site
326424008779	putative PBP binding loops; other site
326424008780	ABC-ATPase subunit interface; other site
326424008781	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
326424008782	The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_15; cd08492
326424008783	alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859
326424008784	drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711
326424008785	Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141
326424008786	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
326424008787	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; cl12078
326424008788	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
326424008789	Helix-turn-helix domains; Region: HTH; cl00088
326424008790	Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109
326424008791	Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109
326424008792	Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109
326424008793	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173
326424008794	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
326424008795	ABC-ATPase subunit interface; other site
326424008796	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
326424008797	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427
326424008798	The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_15; cd08492
326424008799	Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496
326424008800	Family of homologous FMN-dependent alpha-hydroxyacid oxidizing enzymes. This family occurs in both prokaryotes and eukaryotes. Members of this family include flavocytochrome b2 (FCB2), glycolate oxidase (GOX), lactate monooxygenase (LMO), mandelate...; Region: alpha_hydroxyacid_oxid_FMN; cd02809
326424008801	active site
326424008802	substrate binding site [chemical binding]; other site
326424008803	putative catalytic residues [active]
326424008804	Family of homologous FMN-dependent alpha-hydroxyacid oxidizing enzymes. This family occurs in both prokaryotes and eukaryotes. Members of this family include flavocytochrome b2 (FCB2), glycolate oxidase (GOX), lactate monooxygenase (LMO), mandelate...; Region: alpha_hydroxyacid_oxid_FMN; cd02809
326424008805	FMN binding site [chemical binding]; other site
326424008806	Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318
326424008807	AMP-binding enzyme; Region: AMP-binding; cl15778
326424008808	Phosphopantetheine attachment site; Region: PP-binding; cl09936
326424008809	Thioesterase domain; Region: Thioesterase; pfam00975
326424008810	Predicted metalloendopeptidase [Posttranslational modification, protein turnover, chaperones]; Region: PepO; COG3590
326424008811	Peptidase family M13 includes neprilysin, endothelin-converting enzyme I; Region: M13; cd08662
326424008812	active site
326424008813	Zn binding site [ion binding]; other site
326424008814	Predicted glycosyltransferases [General function prediction only]; Region: COG1216
326424008815	Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186
326424008816	Probable Catalytic site; other site
326424008817	metal-binding site
326424008818	Transcriptional regulator [Transcription]; Region: LysR; COG0583
326424008819	Helix-turn-helix domains; Region: HTH; cl00088
326424008820	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
326424008821	dimerization interface [polypeptide binding]; other site
326424008822	Acyl-CoA dehydrogenase (ACAD) 10 and 11, N-terminal domain, and similar proteins. This subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: ACAD10_11_like; cd05154
326424008823	putative active site [active]
326424008824	putative substrate binding site [chemical binding]; other site
326424008825	ATP binding site [chemical binding]; other site
326424008826	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; cl12078
326424008827	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
326424008828	Rhodococcus ruber 6-oxolauric acid dehydrogenase-like and related proteins; Region: ALDH_CddD-AldA-like; cd07089
326424008829	NAD binding site [chemical binding]; other site
326424008830	catalytic residues [active]
326424008831	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
326424008832	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
326424008833	active site
326424008834	metal binding site [ion binding]; metal-binding site
326424008835	Evidence 7 : Gene remnant; Product type e : enzyme
326424008836	TIGR03086 family protein; Region: TIGR03086
326424008837	Protein of unknown function (DUF1360); Region: DUF1360; pfam07098
326424008838	Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381
326424008839	Protein of unknown function (DUF2637); Region: DUF2637; pfam10935
326424008840	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
326424008841	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
326424008842	Protein of unknown function DUF72; Region: DUF72; cl00777
326424008843	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
326424008844	Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378
326424008845	substrate binding site [chemical binding]; other site
326424008846	oxyanion hole (OAH) forming residues; other site
326424008847	trimer interface [polypeptide binding]; other site
326424008848	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761
326424008849	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
326424008850	C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776
326424008851	N-terminal domain interface [polypeptide binding]; other site
326424008852	dimer interface [polypeptide binding]; other site
326424008853	substrate binding pocket (H-site) [chemical binding]; other site
326424008854	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cl02931
326424008855	Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938
326424008856	iron-sulfur cluster [ion binding]; other site
326424008857	[2Fe-2S] cluster binding site [ion binding]; other site
326424008858	RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
326424008859	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
326424008860	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
326424008861	DNA binding residues [nucleotide binding]
326424008862	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
326424008863	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
326424008864	active site
326424008865	phosphorylation site [posttranslational modification]
326424008866	intermolecular recognition site; other site
326424008867	dimerization interface [polypeptide binding]; other site
326424008868	Helix-turn-helix domains; Region: HTH; cl00088
326424008869	dimerization interface [polypeptide binding]; other site
326424008870	DNA binding residues [nucleotide binding]
326424008871	2TM domain; Region: 2TM; pfam13239
326424008872	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585
326424008873	Histidine kinase; Region: HisKA_3; pfam07730
326424008874	Predicted membrane protein [Function unknown]; Region: COG2311
326424008875	Protein of unknown function (DUF418); Region: DUF418; cl12135
326424008876	Protein of unknown function (DUF418); Region: DUF418; cl12135
326424008877	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
326424008878	active site
326424008879	ATP binding site [chemical binding]; other site
326424008880	substrate binding site [chemical binding]; other site
326424008881	Predicted membrane protein [Function unknown]; Region: COG4270
326424008882	TIR domain; Region: TIR_2; cl15770
326424008883	Tetratricopeptide repeat; Region: TPR_10; pfam13374
326424008884	Tetratricopeptide repeat; Region: TPR_10; pfam13374
326424008885	Tetratricopeptide repeat; Region: TPR_12; pfam13424
326424008886	Tetratricopeptide repeat; Region: TPR_12; pfam13424
326424008887	Tetratricopeptide repeat; Region: TPR_12; pfam13424
326424008888	Tetratricopeptide repeat; Region: TPR_12; pfam13424
326424008889	Tetratricopeptide repeat; Region: TPR_12; pfam13424
326424008890	Cyanase C-terminal domain. Cyanase (Cyanate lyase) is responsible for the hydrolysis of cyanate.  It catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide. This allows organisms that possess the enzyme to overcome the...; Region: Cyanase_C; cl07841
326424008891	Protein of unknown function (DUF1006); Region: DUF1006; cl15826
326424008892	Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843
326424008893	Ubiquinol oxidase subunit I.  Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane.  It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662
326424008894	D-pathway; other site
326424008895	Putative ubiquinol binding site [chemical binding]; other site
326424008896	Low-spin heme (heme b) binding site [chemical binding]; other site
326424008897	Putative water exit pathway; other site
326424008898	Binuclear center (heme o3/CuB) [ion binding]; other site
326424008899	K-pathway; other site
326424008900	Putative proton exit pathway; other site
326424008901	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
326424008902	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200
326424008903	structural tetrad; other site
326424008904	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567
326424008905	structural tetrad; other site
326424008906	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567
326424008907	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
326424008908	type VI secretion system FHA domain protein; Region: VI_FHA; TIGR03354
326424008909	phosphopeptide binding site; other site
326424008910	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
326424008911	phosphopeptide binding site; other site
326424008912	ABCG transporters are involved in eye pigment (EP) precursor transport, regulation of lipid-trafficking mechanisms, and pleiotropic drug resistance (DR).  DR is a well-described phenomenon occurring in fungi and shares several similarities with processes...; Region: ABCG_EPDR; cd03213
326424008913	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
326424008914	Walker A/P-loop; other site
326424008915	ATP binding site [chemical binding]; other site
326424008916	Q-loop/lid; other site
326424008917	ABC transporter signature motif; other site
326424008918	Walker B; other site
326424008919	D-loop; other site
326424008920	H-loop/switch region; other site
326424008921	ABC-2 type transporter; Region: ABC2_membrane; cl11417
326424008922	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2258
326424008923	MOSC domain; Region: MOSC; pfam03473
326424008924	Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318
326424008925	AMP-binding enzyme; Region: AMP-binding; cl15778
326424008926	YqcI/YcgG family; Region: YqcI_YcgG; cl01349
326424008927	MbtH-like protein; Region: MbtH; cl01279
326424008928	Peptide arylation enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntE; COG1021
326424008929	AMP-binding enzyme; Region: AMP-binding; cl15778
326424008930	salicylate synthase; Region: salicyl_syn; TIGR03494
326424008931	chorismate binding enzyme; Region: Chorismate_bind; cl10555
326424008932	Phosphopantetheine attachment site; Region: PP-binding; cl09936
326424008933	Condensation domain; Region: Condensation; pfam00668
326424008934	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
326424008935	Nonribosomal peptide synthase; Region: NRPS; pfam08415
326424008936	Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318
326424008937	AMP-binding enzyme; Region: AMP-binding; cl15778
326424008938	AMP-binding enzyme; Region: AMP-binding; cl15778
326424008939	Phosphopantetheine attachment site; Region: PP-binding; cl09936
326424008940	MbtH-like protein; Region: MbtH; cl01279
326424008941	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
326424008942	ABC-ATPase subunit  interface; other site
326424008943	dimer interface [polypeptide binding]; other site
326424008944	putative PBP binding regions; other site
326424008945	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
326424008946	ABC-ATPase subunit  interface; other site
326424008947	dimer interface [polypeptide binding]; other site
326424008948	putative PBP binding regions; other site
326424008949	lipid A export permease/ATP-binding protein MsbA; Region: MsbA_lipidA; TIGR02203
326424008950	ABC transporter transmembrane region; Region: ABC_membrane; cl00549
326424008951	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
326424008952	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
326424008953	Walker A/P-loop; other site
326424008954	ATP binding site [chemical binding]; other site
326424008955	Q-loop/lid; other site
326424008956	ABC transporter signature motif; other site
326424008957	Walker B; other site
326424008958	D-loop; other site
326424008959	H-loop/switch region; other site
326424008960	Clavaminic acid synthetase (CAS) -like;  CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cl00184
326424008961	peptide synthase; Provisional; Region: PRK12316
326424008962	AMP-binding enzyme; Region: AMP-binding; cl15778
326424008963	acyl-CoA synthetase; Validated; Region: PRK08308
326424008964	Phosphopantetheine attachment site; Region: PP-binding; cl09936
326424008965	Thioesterase domains of type I polyketide synthases or non-ribosomal peptide synthetases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3319
326424008966	Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+.  Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262
326424008967	Periplasmic binding protein; Region: Peripla_BP_2; pfam01497
326424008968	intersubunit interface [polypeptide binding]; other site
326424008969	peptide synthase; Provisional; Region: PRK12467
326424008970	AMP-binding enzyme; Region: AMP-binding; cl15778
326424008971	enterobactin synthase subunit F; Provisional; Region: entF; PRK10252
326424008972	Phosphopantetheine attachment site; Region: PP-binding; cl09936
326424008973	peptide synthase; Provisional; Region: PRK12316
326424008974	HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745
326424008975	AMP-binding enzyme; Region: AMP-binding; cl15778
326424008976	HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745
326424008977	peptide synthase; Provisional; Region: PRK12467
326424008978	AMP-binding enzyme; Region: AMP-binding; cl15778
326424008979	Phosphopantetheine attachment site; Region: PP-binding; cl09936
326424008980	HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745
326424008981	AMP-binding enzyme; Region: AMP-binding; cl15778
326424008982	Phosphopantetheine attachment site; Region: PP-binding; cl09936
326424008983	non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261
326424008984	peptide synthase; Provisional; Region: PRK12316
326424008985	HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745
326424008986	AMP-binding enzyme; Region: AMP-binding; cl15778
326424008987	Phosphopantetheine attachment site; Region: PP-binding; cl09936
326424008988	peptide synthase; Validated; Region: PRK05691
326424008989	non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261
326424008990	Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cl00161
326424008991	choline-sulfatase; Region: chol_sulfatase; TIGR03417
326424008992	Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917
326424008993	NodB motif; other site
326424008994	active site
326424008995	catalytic site [active]
326424008996	metal binding site [ion binding]; metal-binding site
326424008997	Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917
326424008998	NodB motif; other site
326424008999	active site
326424009000	metal binding site [ion binding]; metal-binding site
326424009001	catalytic site [active]
326424009002	Uncharacterized conserved protein [Function unknown]; Region: COG3391
326424009003	40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276
326424009004	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587
326424009005	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
326424009006	active site
326424009007	metal binding site [ion binding]; metal-binding site
326424009008	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
326424009009	putative active site [active]
326424009010	Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718
326424009011	Protein of unknown function N-terminus (DUF3323); Region: DUF3323; pfam11796
326424009012	TIGR02680 family protein; Region: TIGR02680
326424009013	Putative exonuclease SbcCD, C subunit; Region: SbcCD_C; pfam13558
326424009014	helicase, putative, RecD/TraA family; Region: recD_rel; TIGR01448
326424009015	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
326424009016	Family description; Region: UvrD_C_2; cl15862
326424009017	acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946
326424009018	Tetratricopeptide repeat; Region: TPR_16; pfam13432
326424009019	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
326424009020	binding surface
326424009021	TPR motif; other site
326424009022	Tetratricopeptide repeat; Region: TPR_12; pfam13424
326424009023	Tetratricopeptide repeat; Region: TPR_12; pfam13424
326424009024	Tetratricopeptide repeat; Region: TPR_12; pfam13424
326424009025	Tetratricopeptide repeat; Region: TPR_12; pfam13424
326424009026	putative PEP-CTERM system TPR-repeat lipoprotein; Region: PEP_TPR_lipo; TIGR02917
326424009027	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
326424009028	TPR motif; other site
326424009029	binding surface
326424009030	Tetratricopeptide repeat; Region: TPR_12; pfam13424
326424009031	Tetratricopeptide repeat; Region: TPR_12; pfam13424
326424009032	CHAT domain; Region: CHAT; pfam12770
326424009033	Helix-turn-helix domains; Region: HTH; cl00088
326424009034	Bacterial transcriptional activator domain; Region: BTAD; pfam03704
326424009035	Response regulator receiver domain; Region: Response_reg; pfam00072
326424009036	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
326424009037	active site
326424009038	phosphorylation site [posttranslational modification]
326424009039	intermolecular recognition site; other site
326424009040	dimerization interface [polypeptide binding]; other site
326424009041	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
326424009042	dimerization interface [polypeptide binding]; other site
326424009043	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
326424009044	dimer interface [polypeptide binding]; other site
326424009045	phosphorylation site [posttranslational modification]
326424009046	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
326424009047	ATP binding site [chemical binding]; other site
326424009048	Mg2+ binding site [ion binding]; other site
326424009049	G-X-G motif; other site
326424009050	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
326424009051	active site
326424009052	phosphorylation site [posttranslational modification]
326424009053	intermolecular recognition site; other site
326424009054	dimerization interface [polypeptide binding]; other site
326424009055	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cl00086
326424009056	Sodium:solute symporter family; Region: SSF; cl00456
326424009057	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
326424009058	Rhodococcus ruber 6-oxolauric acid dehydrogenase-like and related proteins; Region: ALDH_CddD-AldA-like; cd07089
326424009059	NAD binding site [chemical binding]; other site
326424009060	catalytic residues [active]
326424009061	Helix-turn-helix domains; Region: HTH; cl00088
326424009062	Transcriptional regulators [Transcription]; Region: MarR; COG1846
326424009063	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
326424009064	dimerization interface [polypeptide binding]; other site
326424009065	putative DNA binding site [nucleotide binding]; other site
326424009066	putative Zn2+ binding site [ion binding]; other site
326424009067	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
326424009068	putative substrate translocation pore; other site
326424009069	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; cl12078
326424009070	Predicted RNA polymerase sigma factor containing a TPR repeat domain [Transcription]; Region: COG4941
326424009071	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
326424009072	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761
326424009073	YCII-related domain; Region: YCII; cl00999
326424009074	Old yellow enzyme (OYE)-related FMN binding domain, group 5.  Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a reducing agent with oxygens, quinones, and alpha,beta-unsaturated aldehydes and ketones, and can act as...; Region: OYE_like_5_FMN; cd04747
326424009075	putative active site [active]
326424009076	putative FMN binding site [chemical binding]; other site
326424009077	putative substrate binding site [chemical binding]; other site
326424009078	putative catalytic residue [active]
326424009079	The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709
326424009080	Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175
326424009081	Clavaminic acid synthetase (CAS) -like;  CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cl00184
326424009082	Predicted integral membrane proteins containing uncharacterized repeats [Function unknown]; Region: COG5563
326424009083	probable extracellular repeat, HAF family; Region: HAF_rpt; TIGR02913
326424009084	probable extracellular repeat, HAF family; Region: HAF_rpt; TIGR02913
326424009085	bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14190
326424009086	Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763
326424009087	NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080
326424009088	homodimer interface [polypeptide binding]; other site
326424009089	NADP binding site [chemical binding]; other site
326424009090	substrate binding site [chemical binding]; other site
326424009091	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
326424009092	S-adenosylmethionine binding site [chemical binding]; other site
326424009093	topology modulation protein; Reviewed; Region: PRK08118
326424009094	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
326424009095	Protein of unknown function (DUF2510); Region: DUF2510; pfam10708
326424009096	Scramblase; Region: Scramblase; cl02043
326424009097	ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488
326424009098	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
326424009099	Walker A/P-loop; other site
326424009100	ATP binding site [chemical binding]; other site
326424009101	Q-loop/lid; other site
326424009102	ABC transporter signature motif; other site
326424009103	Walker B; other site
326424009104	D-loop; other site
326424009105	H-loop/switch region; other site
326424009106	ABC transporter; Region: ABC_tran_2; pfam12848
326424009107	ABCF_EF-3  Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth.  EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221
326424009108	DNA repair photolyase [DNA replication, recombination, and repair]; Region: SplB; COG1533
326424009109	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
326424009110	FeS/SAM binding site; other site
326424009111	Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381
326424009112	Protein of unknown function (DUF402); Region: DUF402; cl00979
326424009113	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
326424009114	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
326424009115	N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357
326424009116	Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cl15820
326424009117	Putative esterase; Region: Esterase; pfam00756
326424009118	Uncharacterized conserved protein (DUF2156); Region: DUF2156; cl12090
326424009119	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
326424009120	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
326424009121	P-loop; other site
326424009122	Magnesium ion binding site [ion binding]; other site
326424009123	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
326424009124	Magnesium ion binding site [ion binding]; other site
326424009125	drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711
326424009126	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
326424009127	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
326424009128	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
326424009129	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
326424009130	Ligand Binding Site [chemical binding]; other site
326424009131	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
326424009132	Ligand Binding Site [chemical binding]; other site
326424009133	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
326424009134	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box protein; Region: CSP_CDS; cd04458
326424009135	DNA-binding site [nucleotide binding]; DNA binding site
326424009136	RNA-binding motif; other site
326424009137	Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520
326424009138	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
326424009139	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
326424009140	catalytic residue [active]
326424009141	Leucine carboxyl methyltransferase; Region: LCM; cl01306
326424009142	Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cl00246
326424009143	FAD binding site [chemical binding]; other site
326424009144	Bacterial cytosine deaminase and related metal-dependent hydrolases. Cytosine deaminases (CDs) catalyze the deamination of cytosine, producing uracil and ammonia. They play an important role in pyrimidine salvage. CDs are present in prokaryotes and fungi; Region: Bact_CD; cd01293
326424009145	cytosine deaminase; Validated; Region: PRK07572
326424009146	active site
326424009147	ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116
326424009148	NrtD and SsuB are the ATP-binding subunits of the bacterial ABC-type nitrate and sulfonate transport systems, respectively.  ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars; Region: ABC_NrtD_SsuB_transporters; cd03293
326424009149	Walker A/P-loop; other site
326424009150	ATP binding site [chemical binding]; other site
326424009151	Q-loop/lid; other site
326424009152	ABC transporter signature motif; other site
326424009153	Walker B; other site
326424009154	D-loop; other site
326424009155	H-loop/switch region; other site
326424009156	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
326424009157	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
326424009158	dimer interface [polypeptide binding]; other site
326424009159	conserved gate region; other site
326424009160	putative PBP binding loops; other site
326424009161	ABC-ATPase subunit interface; other site
326424009162	FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277
326424009163	FAD binding domain; Region: FAD_binding_4; pfam01565
326424009164	Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381
326424009165	Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233
326424009166	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
326424009167	Creatinine amidohydrolase; Region: Creatininase; cl00618
326424009168	Luciferase-like monooxygenase; Region: Bac_luciferase; pfam00296
326424009169	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
326424009170	Cupin domain; Region: Cupin_2; cl09118
326424009171	Amidase; Region: Amidase; cl11426
326424009172	Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446
326424009173	Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109
326424009174	Cupin domain; Region: Cupin_2; cl09118
326424009175	Isochorismatase family; Region: Isochorismatase; pfam00857
326424009176	Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431
326424009177	catalytic triad [active]
326424009178	conserved cis-peptide bond; other site
326424009179	Acetamidase/Formamidase family; Region: FmdA_AmdA; cl01023
326424009180	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
326424009181	sequence-specific DNA binding site [nucleotide binding]; other site
326424009182	salt bridge; other site
326424009183	putative luciferase-like monooxygenase, FMN-dependent, CE1758 family; Region: LLM_CE1758_fam; TIGR04036
326424009184	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
326424009185	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
326424009186	NAD(P) binding site [chemical binding]; other site
326424009187	ATP-dependent Clp protease proteolytic subunit; Reviewed; Region: PRK12553
326424009188	Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017
326424009189	oligomer interface [polypeptide binding]; other site
326424009190	active site residues [active]
326424009191	Clp protease; Region: CLP_protease; pfam00574
326424009192	Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017
326424009193	oligomer interface [polypeptide binding]; other site
326424009194	active site residues [active]
326424009195	Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600
326424009196	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
326424009197	DNA binding residues [nucleotide binding]
326424009198	Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600
326424009199	DNA binding residues [nucleotide binding]
326424009200	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
326424009201	Methylmalonyl-CoA epimerase (MMCE); Region: MMCE; cd07249
326424009202	dimer interface [polypeptide binding]; other site
326424009203	substrate binding site [chemical binding]; other site
326424009204	metal binding site [ion binding]; metal-binding site
326424009205	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
326424009206	NAD(P) binding site [chemical binding]; other site
326424009207	active site
326424009208	LppP/LprE lipoprotein; Region: Lipoprotein_21; pfam14041
326424009209	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
326424009210	Methylomonas sp. 4,4'-diapolycopene-dialdehyde dehydrogenase-like; Region: ALDH_DDALDH; cd07099
326424009211	NAD(P) binding site [chemical binding]; other site
326424009212	catalytic residues [active]
326424009213	pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_x; TIGR03181
326424009214	Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000
326424009215	TPP-binding site [chemical binding]; other site
326424009216	tetramer interface [polypeptide binding]; other site
326424009217	heterodimer interface [polypeptide binding]; other site
326424009218	phosphorylation loop region [posttranslational modification]
326424009219	Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein; Region: Hint; cl15780
326424009220	hypothetical protein; Reviewed; Region: PRK09588
326424009221	Putative multicopper oxidases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: SufI; COG2132
326424009222	Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; cl11412
326424009223	Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; cl11412
326424009224	Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; cl11412
326424009225	Zn-finger in ubiquitin-hydrolases and other protein; Region: zf-UBP; cl09957
326424009226	2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy; cl15773
326424009227	Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350
326424009228	6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870
326424009229	The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445
326424009230	active site
326424009231	DNA binding site [nucleotide binding]
326424009232	Adenosine deaminase [Nucleotide transport and metabolism]; Region: Ada; COG2169
326424009233	Metal binding domain of Ada; Region: Ada_Zn_binding; pfam02805
326424009234	AlkA N-terminal domain; Region: AlkA_N; cl05528
326424009235	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786
326424009236	minor groove reading motif; other site
326424009237	helix-hairpin-helix signature motif; other site
326424009238	SIRT4: Eukaryotic and prokaryotic group (class2) which includes human sirtuin SIRT4 and several bacterial homologs; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein...; Region: SIRT4; cd01409
326424009239	NAD+ binding site [chemical binding]; other site
326424009240	substrate binding site [chemical binding]; other site
326424009241	Zn binding site [ion binding]; other site
326424009242	HupF/HypC family; Region: HupF_HypC; cl00394
326424009243	Virulence factor BrkB; Region: Virul_fac_BrkB; cl07918
326424009244	NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252
326424009245	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
326424009246	Protein of unknown function (DUF3604); Region: DUF3604; pfam12228
326424009247	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: APH_ChoK_like; cd05120
326424009248	active site
326424009249	substrate binding site [chemical binding]; other site
326424009250	ATP binding site [chemical binding]; other site
326424009251	Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_17; cd04676
326424009252	nudix motif; other site
326424009253	Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239
326424009254	Frankia paralogous domain; Region: Frankia_40_dom; TIGR03917
326424009255	Bacterial Ig-like domain; Region: Big_5; cl01012
326424009256	Cytochrome c oxidase caa3 assembly factor (Caa3_CtaG); Region: Caa3_CtaG; cl09173
326424009257	Na+/H+ antiporter 1; Region: Na_H_antiport_1; cl01133
326424009258	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
326424009259	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474
326424009260	Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391
326424009261	Bacitracin resistance protein BacA; Region: BacA; cl00858
326424009262	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
326424009263	heavy metal translocating P-type ATPase; Region: ATPase-IB_hvy; TIGR01525
326424009264	Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246
326424009265	Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391
326424009266	Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689
326424009267	mycofactocin system transcriptional regulator; Region: mycofact_TetR; TIGR03968
326424009268	Helix-turn-helix domains; Region: HTH; cl00088
326424009269	mycofactocin system FadH/OYE family oxidoreductase 1; Region: mycofact_OYE_1; TIGR03996
326424009270	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl09108
326424009271	phosphate binding site [ion binding]; other site
326424009272	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
326424009273	mycofactocin system FadH/OYE family oxidoreductase 2; Region: mycofact_OYE_2; TIGR03997
326424009274	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl09108
326424009275	phosphate binding site [ion binding]; other site
326424009276	salicylyl-CoA 5-hydroxylase; Reviewed; Region: PRK08255
326424009277	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
326424009278	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
326424009279	Aspartate/tyrosine/aromatic aminotransferase [Amino acid transport and metabolism]; Region: COG0436
326424009280	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
326424009281	pyridoxal 5'-phosphate binding site [chemical binding]; other site
326424009282	homodimer interface [polypeptide binding]; other site
326424009283	catalytic residue [active]
326424009284	N-Dimethylarginine dimethylaminohydrolase [Amino acid transport and metabolism]; Region: COG1834
326424009285	Amidinotransferase; Region: Amidinotransf; cl12043
326424009286	Catalytic domain of Protein Kinases; Region: PKc; cd00180
326424009287	active site
326424009288	ATP binding site [chemical binding]; other site
326424009289	substrate binding site [chemical binding]; other site
326424009290	activation loop (A-loop); other site
326424009291	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567
326424009292	Siderophore-interacting protein [Inorganic ion transport and metabolism]; Region: ViuB; COG2375
326424009293	Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193
326424009294	FAD binding pocket [chemical binding]; other site
326424009295	FAD binding motif [chemical binding]; other site
326424009296	phosphate binding motif [ion binding]; other site
326424009297	NAD binding pocket [chemical binding]; other site
326424009298	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
326424009299	ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120
326424009300	Walker A/P-loop; other site
326424009301	ATP binding site [chemical binding]; other site
326424009302	Q-loop/lid; other site
326424009303	ABC transporter signature motif; other site
326424009304	Walker B; other site
326424009305	D-loop; other site
326424009306	H-loop/switch region; other site
326424009307	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
326424009308	Catalytic domain of Protein Kinases; Region: PKc; cd00180
326424009309	active site
326424009310	ATP binding site [chemical binding]; other site
326424009311	substrate binding site [chemical binding]; other site
326424009312	activation loop (A-loop); other site
326424009313	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
326424009314	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
326424009315	substrate binding pocket [chemical binding]; other site
326424009316	membrane-bound complex binding site; other site
326424009317	hinge residues; other site
326424009318	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076
326424009319	NMT1-like family; Region: NMT1_2; cl15260
326424009320	Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695
326424009321	Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605
326424009322	Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081
326424009323	Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777
326424009324	Bacterioferritin (cytochrome b1) [Inorganic ion transport and metabolism]; Region: Bfr; COG2193
326424009325	Bacterioferritin, ferritin-like diiron-binding domain; Region: Bacterioferritin; cd00907
326424009326	heme binding site [chemical binding]; other site
326424009327	ferroxidase pore; other site
326424009328	ferroxidase diiron center [ion binding]; other site
326424009329	Response regulator receiver domain; Region: Response_reg; pfam00072
326424009330	CoA-transferase family III; Region: CoA_transf_3; pfam02515
326424009331	Mitochondrial biogenesis AIM24; Region: AIM24; cl00884
326424009332	NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961
326424009333	NAD(P) binding site [chemical binding]; other site
326424009334	catalytic residues [active]
326424009335	Proline dehydrogenase; Region: Pro_dh; cl03282
326424009336	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
326424009337	Catalytic domain of Protein Kinases; Region: PKc; cd00180
326424009338	active site
326424009339	ATP binding site [chemical binding]; other site
326424009340	substrate binding site [chemical binding]; other site
326424009341	activation loop (A-loop); other site
326424009342	Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cl00065
326424009343	Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cl00065
326424009344	Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cl00065
326424009345	Protein of unknown function (DUF742); Region: DUF742; pfam05331
326424009346	Roadblock/LC7 domain; Region: Robl_LC7; cl00886
326424009347	Nitrate and nitrite sensing; Region: NIT; pfam08376
326424009348	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054
326424009349	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
326424009350	ATP binding site [chemical binding]; other site
326424009351	Mg2+ binding site [ion binding]; other site
326424009352	G-X-G motif; other site
326424009353	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
326424009354	ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116
326424009355	NrtD and SsuB are the ATP-binding subunits of the bacterial ABC-type nitrate and sulfonate transport systems, respectively.  ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars; Region: ABC_NrtD_SsuB_transporters; cd03293
326424009356	Walker A/P-loop; other site
326424009357	ATP binding site [chemical binding]; other site
326424009358	Q-loop/lid; other site
326424009359	ABC transporter signature motif; other site
326424009360	Walker B; other site
326424009361	D-loop; other site
326424009362	H-loop/switch region; other site
326424009363	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
326424009364	dimer interface [polypeptide binding]; other site
326424009365	conserved gate region; other site
326424009366	ABC-ATPase subunit interface; other site
326424009367	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
326424009368	N-ethylammeline chlorohydrolase; Provisional; Region: PRK06038
326424009369	active site
326424009370	transcriptional regulator NarP; Provisional; Region: PRK10403
326424009371	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
326424009372	DNA binding residues [nucleotide binding]
326424009373	dimerization interface [polypeptide binding]; other site
326424009374	Necrosis inducing protein (NPP1); Region: NPP1; pfam05630
326424009375	Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389
326424009376	putative active site [active]
326424009377	putative metal binding site [ion binding]; other site
326424009378	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
326424009379	O-acetylhomoserine aminocarboxypropyltransferase; Validated; Region: PRK07812
326424009380	CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614
326424009381	homodimer interface [polypeptide binding]; other site
326424009382	substrate-cofactor binding pocket; other site
326424009383	pyridoxal 5'-phosphate binding site [chemical binding]; other site
326424009384	catalytic residue [active]
326424009385	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
326424009386	Homoserine acetyltransferase [Amino acid transport and metabolism]; Region: MET2; COG2021
326424009387	Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418
326424009388	RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013
326424009389	putative active site [active]
326424009390	glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650
326424009391	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
326424009392	Walker A/P-loop; other site
326424009393	ATP binding site [chemical binding]; other site
326424009394	Q-loop/lid; other site
326424009395	ABC transporter signature motif; other site
326424009396	Walker B; other site
326424009397	D-loop; other site
326424009398	H-loop/switch region; other site
326424009399	TOBE domain; Region: TOBE_2; cl01440
326424009400	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
326424009401	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
326424009402	Enterobacter aerogenes GpdQ and related proteins, metallophosphatase domain; Region: MPP_GpdQ; cd07402
326424009403	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
326424009404	active site
326424009405	metal binding site [ion binding]; metal-binding site
326424009406	hexamer interface [polypeptide binding]; other site
326424009407	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
326424009408	dimer interface [polypeptide binding]; other site
326424009409	conserved gate region; other site
326424009410	ABC-ATPase subunit interface; other site
326424009411	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
326424009412	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
326424009413	dimer interface [polypeptide binding]; other site
326424009414	conserved gate region; other site
326424009415	putative PBP binding loops; other site
326424009416	ABC-ATPase subunit interface; other site
326424009417	Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670
326424009418	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
326424009419	Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109
326424009420	3-ketosteroid-delta-1-dehydrogenase; Reviewed; Region: PRK07843
326424009421	Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to PFK family that includes ATP- and pyrophosphate (PPi)- dependent phosphofructokinases; Region: PFK; cl00204
326424009422	active site
326424009423	ADP/pyrophosphate binding site [chemical binding]; other site
326424009424	dimerization interface [polypeptide binding]; other site
326424009425	allosteric effector site; other site
326424009426	fructose-1,6-bisphosphate binding site; other site
326424009427	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567
326424009428	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
326424009429	AAA-like domain; Region: AAA_10; pfam12846
326424009430	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
326424009431	Family description; Region: UvrD_C_2; cl15862
326424009432	Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277
326424009433	putative active site [active]
326424009434	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
326424009435	substrate binding site [chemical binding]; other site
326424009436	oxyanion hole (OAH) forming residues; other site
326424009437	trimer interface [polypeptide binding]; other site
326424009438	Flavin Reductases; Region: FlaRed; cl00801
326424009439	DNA polymerase Ligase (LigD); Region: LigD_N; cl11819
326424009440	Adenylation domain of Mycobacterium tuberculosis LigD and LigC-like ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_LigD_LigC; cd07906
326424009441	DNA polymerase LigD, ligase domain; Region: NHEJ_ligase_lig; TIGR02779
326424009442	active site
326424009443	DNA binding site [nucleotide binding]
326424009444	The Oligonucleotide/oligosaccharide binding (OB)-fold domain of ATP-dependent DNA ligase LigD is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_LigD; cd07971
326424009445	DNA binding site [nucleotide binding]
326424009446	Antibiotic biosynthesis monooxygenase; Region: ABM; cl10022
326424009447	Antibiotic biosynthesis monooxygenase; Region: ABM; cl10022
326424009448	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
326424009449	3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830
326424009450	NAD(P) binding site [chemical binding]; other site
326424009451	active site
326424009452	beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150
326424009453	Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938
326424009454	active site
326424009455	Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834
326424009456	beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150
326424009457	dimer interface [polypeptide binding]; other site
326424009458	active site
326424009459	Cupin domain; Region: Cupin_2; cl09118
326424009460	N-terminal aromatase/cyclase domain of the multifunctional protein tetracenomycin (TcmN) and related domains; Region: TcmN_ARO-CYC_like; cd08860
326424009461	putative hydrophobic ligand binding site [chemical binding]; other site
326424009462	active site
326424009463	catalytic residues_2 [active]
326424009464	catalytic residues_1 [active]
326424009465	Phosphopantetheine attachment site; Region: PP-binding; cl09936
326424009466	Polyketide synthesis cyclase; Region: Cyclase_polyket; pfam04673
326424009467	Predicted transcriptional regulators [Transcription]; Region: COG1378
326424009468	Helix-turn-helix domains; Region: HTH; cl00088
326424009469	Helix-turn-helix domains; Region: HTH; cl00088
326424009470	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
326424009471	Protein of unknown function (DUF742); Region: DUF742; pfam05331
326424009472	Roadblock/LC7 domain; Region: Robl_LC7; cl00886
326424009473	Nitrate and nitrite sensing; Region: NIT; pfam08376
326424009474	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
326424009475	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
326424009476	ATP binding site [chemical binding]; other site
326424009477	Mg2+ binding site [ion binding]; other site
326424009478	G-X-G motif; other site
326424009479	Thioesterase-like superfamily; Region: 4HBT_3; pfam13622
326424009480	The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509
326424009481	active site 2 [active]
326424009482	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
326424009483	substrate binding site [chemical binding]; other site
326424009484	oxyanion hole (OAH) forming residues; other site
326424009485	trimer interface [polypeptide binding]; other site
326424009486	Protein of unknown function (DUF445); Region: DUF445; pfam04286
326424009487	ATP-dependent RNA helicase RhlE; Provisional; Region: PRK10590
326424009488	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
326424009489	ATP binding site [chemical binding]; other site
326424009490	Mg++ binding site [ion binding]; other site
326424009491	motif III; other site
326424009492	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
326424009493	nucleotide binding region [chemical binding]; other site
326424009494	ATP-binding site [chemical binding]; other site
326424009495	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
326424009496	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
326424009497	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
326424009498	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
326424009499	catalytic residue [active]
326424009500	DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673
326424009501	Bacterial DNA polymerase III alpha subunit; Region: DNA_pol3_alpha; pfam07733
326424009502	DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485
326424009503	generic binding surface II; other site
326424009504	generic binding surface I; other site
326424009505	Mycolic acid cyclopropane synthetase; Region: CMAS; pfam02353
326424009506	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
326424009507	Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342
326424009508	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
326424009509	catalytic residue [active]
326424009510	Polyphosphate kinase 2 (PPK2); Region: PPK2; cl11971
326424009511	NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961
326424009512	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
326424009513	NAD(P) binding site [chemical binding]; other site
326424009514	catalytic residues [active]
326424009515	L-lysine aminotransferase; Provisional; Region: PRK08297
326424009516	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
326424009517	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
326424009518	catalytic residue [active]
326424009519	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
326424009520	Catalytic domain of Protein Kinases; Region: PKc; cd00180
326424009521	active site
326424009522	ATP binding site [chemical binding]; other site
326424009523	substrate binding site [chemical binding]; other site
326424009524	activation loop (A-loop); other site
326424009525	LppP/LprE lipoprotein; Region: Lipoprotein_21; pfam14041
326424009526	Protein kinase domain; Region: Pkinase; pfam00069
326424009527	Catalytic domain of Protein Kinases; Region: PKc; cd00180
326424009528	active site
326424009529	ATP binding site [chemical binding]; other site
326424009530	substrate binding site [chemical binding]; other site
326424009531	activation loop (A-loop); other site
326424009532	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
326424009533	Catalytic domain of Protein Kinases; Region: PKc; cd00180
326424009534	active site
326424009535	ATP binding site [chemical binding]; other site
326424009536	substrate binding site [chemical binding]; other site
326424009537	activation loop (A-loop); other site
326424009538	F420-dependent oxidoreductase, MSMEG_4879 family; Region: F420_MSMEG_4879; TIGR03564
326424009539	N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097
326424009540	F420-dependent oxidoreductase, MSMEG_4879 family; Region: F420_MSMEG_4879; TIGR03564
326424009541	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
326424009542	Helix-turn-helix domains; Region: HTH; cl00088
326424009543	Subfamily of the nitroreductase family that includes BluB protein in Rhodobacter capsulatus is involved in the conversion of cobinamide to cobalamin in Cobalamin (vitamin B12) biosynthesis. Nitroreductases typically reduce their substrates by using NAD(P)...; Region: BluB; cd02145
326424009544	putative FMN binding site [chemical binding]; other site
326424009545	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
326424009546	DNA-binding transcriptional regulator HcaR; Provisional; Region: PRK09906
326424009547	Helix-turn-helix domains; Region: HTH; cl00088
326424009548	The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414
326424009549	dimerization interface [polypeptide binding]; other site
326424009550	substrate binding pocket [chemical binding]; other site
326424009551	short chain dehydrogenase; Provisional; Region: PRK06180
326424009552	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
326424009553	NAD(P) binding site [chemical binding]; other site
326424009554	active site
326424009555	OpgC protein; Region: OpgC_C; cl00792
326424009556	OpgC protein; Region: OpgC_C; cl00792
326424009557	Probable transposase; Region: OrfB_IS605; pfam01385
326424009558	Clp protease ATP binding subunit; Region: clpC; CHL00095
326424009559	alkanesulfonate monooxygenase, FMNH(2)-dependent; Region: alk_sulf_monoox; TIGR03565
326424009560	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
326424009561	OsmC-like protein; Region: OsmC; cl00767
326424009562	Protein of unknown function (DUF1211); Region: DUF1211; cl01421
326424009563	Predicted membrane-bound metal-dependent hydrolase (DUF457); Region: DUF457; cl00868
326424009564	Predicted oxidoreductases (related to aryl-alcohol dehydrogenases) [Energy production and conversion]; Region: Tas; COG0667
326424009565	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
326424009566	active site
326424009567	catalytic tetrad [active]
326424009568	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
326424009569	Porcine testicular carbonyl reductase (PTCR)-like, classical (c) SDRs; Region: carb_red_PTCR-like_SDR_c; cd05324
326424009570	glucose-1-dehydrogenase; Provisional; Region: PRK08936
326424009571	NADP binding site [chemical binding]; other site
326424009572	substrate binding site [chemical binding]; other site
326424009573	active site
326424009574	DNA-binding transcriptional activator XapR; Provisional; Region: PRK09986
326424009575	Helix-turn-helix domains; Region: HTH; cl00088
326424009576	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
326424009577	dimerization interface [polypeptide binding]; other site
326424009578	Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017
326424009579	catalytic triad [active]
326424009580	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
326424009581	S-adenosylmethionine binding site [chemical binding]; other site
326424009582	NADPH-dependent FMN reductase; Region: FMN_red; cl00438
326424009583	The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_15; cd08492
326424009584	Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496
326424009585	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
326424009586	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427
326424009587	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173
326424009588	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
326424009589	dimer interface [polypeptide binding]; other site
326424009590	ABC-ATPase subunit interface; other site
326424009591	putative PBP binding loops; other site
326424009592	ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123
326424009593	The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE).  The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257
326424009594	Walker A/P-loop; other site
326424009595	ATP binding site [chemical binding]; other site
326424009596	Q-loop/lid; other site
326424009597	ABC transporter signature motif; other site
326424009598	Walker B; other site
326424009599	D-loop; other site
326424009600	H-loop/switch region; other site
326424009601	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
326424009602	The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE).  The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257
326424009603	Walker A/P-loop; other site
326424009604	ATP binding site [chemical binding]; other site
326424009605	Q-loop/lid; other site
326424009606	ABC transporter signature motif; other site
326424009607	Walker B; other site
326424009608	D-loop; other site
326424009609	H-loop/switch region; other site
326424009610	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
326424009611	N-methyltryptophan oxidase; Provisional; Region: solA; PRK11259
326424009612	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
326424009613	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
326424009614	FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860
326424009615	FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860
326424009616	nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095
326424009617	active site
326424009618	non-prolyl cis peptide bond; other site
326424009619	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
326424009620	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
326424009621	Coenzyme A binding pocket [chemical binding]; other site
326424009622	RelA- and SpoT-like ppGpp Synthetases and Hydrolases, catalytic domain; Region: Rel-Spo_like; cl11966
326424009623	Protein of unknown function DUF86; Region: DUF86; cl01031
326424009624	Integrase core domain; Region: rve; cl01316
326424009625	NADPH-dependent FMN reductase; Region: FMN_red; cl00438
326424009626	Helix-turn-helix domains; Region: HTH; cl00088
326424009627	Bacterial transcriptional activator domain; Region: BTAD; smart01043
326424009628	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
326424009629	Predicted ATPase [General function prediction only]; Region: COG3903
326424009630	Walker A/P-loop; other site
326424009631	ATP binding site [chemical binding]; other site
326424009632	Q-loop/lid; other site
326424009633	ABC transporter signature motif; other site
326424009634	Walker B; other site
326424009635	ABC-2 type transporter; Region: ABC2_membrane; cl11417
326424009636	daunorubicin resistance ABC transporter ATP-binding subunit; Region: drrA; TIGR01188
326424009637	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
326424009638	Walker A/P-loop; other site
326424009639	ATP binding site [chemical binding]; other site
326424009640	Q-loop/lid; other site
326424009641	ABC transporter signature motif; other site
326424009642	Walker B; other site
326424009643	D-loop; other site
326424009644	H-loop/switch region; other site
326424009645	Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020
326424009646	transcriptional activator FtrA; Provisional; Region: ftrA; PRK09393
326424009647	conserved cys residue [active]
326424009648	Nicotinamidase_ related amidohydrolases.  Cysteine hydrolases of unknown function that share the catalytic triad with other amidohydrolases, like nicotinamidase, which converts nicotinamide to nicotinic acid and ammonia; Region: nicotinamidase_related; cd01014
326424009649	catalytic triad [active]
326424009650	conserved cis-peptide bond; other site
326424009651	Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109
326424009652	Animal heme peroxidases and related proteins; Region: An_peroxidase_like; cl14561
326424009653	substrate binding site [chemical binding]; other site
326424009654	Ferritin-like; Region: Ferritin-like; pfam12902
326424009655	Domain of unknown function (DUF4234); Region: DUF4234; pfam14018
326424009656	Putative cyclase; Region: Cyclase; cl00814
326424009657	Mitochondrial biogenesis AIM24; Region: AIM24; cl00884
326424009658	Mitochondrial biogenesis AIM24; Region: AIM24; cl00884
326424009659	Uncharacterized proteins involved in stress response, homologs of TerZ and putative cAMP-binding protein CABP1 [Signal transduction mechanisms]; Region: TerZ; COG2310
326424009660	Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974
326424009661	putative metal binding site [ion binding]; other site
326424009662	Mitochondrial biogenesis AIM24; Region: AIM24; cl00884
326424009663	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
326424009664	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
326424009665	active site
326424009666	catalytic tetrad [active]
326424009667	Clavaminic acid synthetase (CAS) -like;  CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cl00184
326424009668	Domain of unknown function (DUF222); Region: DUF222; pfam02720
326424009669	Sporulation control protein [General function prediction only]; Region: Spo0M; COG4326
326424009670	SpoOM protein; Region: Spo0M; pfam07070
326424009671	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
326424009672	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
326424009673	Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506
326424009674	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
326424009675	asparagine synthase family amidotransferase; Region: trio_amidotrans; TIGR03104
326424009676	Glutamine amidotransferases class-II (GATase) asparagine synthase_B type.  Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a  glutaminase domain and a...; Region: AsnB; cd00712
326424009677	dimer interface [polypeptide binding]; other site
326424009678	active site
326424009679	The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B  catalyzes the...; Region: Asn_Synthase_B_C; cd01991
326424009680	Ligand Binding Site [chemical binding]; other site
326424009681	Molecular Tunnel; other site
326424009682	Glutamate-cysteine ligase family 2(GCS2); Region: GCS2; cl00954
326424009683	carboxylate-amine ligase, YbdK family; Region: gshA_cyan_rel; TIGR02050
326424009684	Uncharacterized conserved protein [Function unknown]; Region: COG2308
326424009685	A circularly permuted ATPgrasp; Region: CP_ATPgrasp_1; cl00503
326424009686	Helix-turn-helix domains; Region: HTH; cl00088
326424009687	DNA-binding transcriptional regulator OxyR; Provisional; Region: PRK11151
326424009688	The C-terminal substrate-binding domain of the LysR-type transcriptional regulator OxyR, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_OxyR; cd08411
326424009689	dimerization interface [polypeptide binding]; other site
326424009690	Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450
326424009691	Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015
326424009692	dimer interface [polypeptide binding]; other site
326424009693	decamer (pentamer of dimers) interface [polypeptide binding]; other site
326424009694	catalytic triad [active]
326424009695	peroxidatic and resolving cysteines [active]
326424009696	C-terminal domain of 1-Cys peroxiredoxin; Region: 1-cysPrx_C; pfam10417
326424009697	alkylhydroperoxidase, AhpD family; Region: ahpD; TIGR00777
326424009698	Carboxymuconolactone decarboxylase family; Region: CMD; cl00460
326424009699	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
326424009700	DNA-binding site [nucleotide binding]; DNA binding site
326424009701	Platelet-activating factor acetylhydrolase, isoform II; Region: PAF-AH_p_II; pfam03403
326424009702	Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695
326424009703	Platelet-activating factor acetylhydrolase, isoform II; Region: PAF-AH_p_II; pfam03403
326424009704	BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; cl01093
326424009705	Uncharacterized protein, linocin/CFP29 homolog [Function unknown]; Region: COG1659
326424009706	Encapsulating protein for peroxidase; Region: Linocin_M18; cl12047
326424009707	Uncharacterized conserved protein [Function unknown]; Region: COG3461
326424009708	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
326424009709	ligand binding site [chemical binding]; other site
326424009710	PAP2_like proteins, Aur1_like subfamily. Yeast Aur1p or Ipc1p is necessary for the addition of inositol phosphate to ceramide, an essential step in yeast sphingolipid synthesis, and is the target of several antifungal compounds such as aureobasidin; Region: PAP2_Aur1_like; cd03386
326424009711	active site
326424009712	Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376
326424009713	Bacterial Ig-like domain; Region: Big_5; cl01012
326424009714	L,D-transpeptidase catalytic domain; Region: YkuD; cl15405
326424009715	urate oxidase; Region: urate_oxi; TIGR03383
326424009716	Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1),  6-pyrovoyl...; Region: TFold; cl00263
326424009717	active site
326424009718	Uncharacterized conserved protein [Function unknown]; Region: COG1912
326424009719	S-adenosyl-l-methionine hydroxide adenosyltransferase; Region: SAM_adeno_trans; pfam01887
326424009720	Protein of unknown function (DUF3099); Region: DUF3099; pfam11298
326424009721	This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_2; cd03814
326424009722	This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_2; cd03814
326424009723	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
326424009724	Members of the SGNH-hydrolase superfamily, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_like_1; cd01832
326424009725	active site
326424009726	catalytic triad [active]
326424009727	oxyanion hole [active]
326424009728	Protein of unknown function (DUF3090); Region: DUF3090; cl12832
326424009729	ferrochelatase; Reviewed; Region: hemH; PRK00035
326424009730	Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411
326424009731	C-terminal domain interface [polypeptide binding]; other site
326424009732	active site
326424009733	Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419
326424009734	active site
326424009735	N-terminal domain interface [polypeptide binding]; other site
326424009736	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557
326424009737	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
326424009738	NAD(P) binding site [chemical binding]; other site
326424009739	active site
326424009740	Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629
326424009741	TPP-binding site [chemical binding]; other site
326424009742	enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK07889
326424009743	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
326424009744	NAD(P) binding site [chemical binding]; other site
326424009745	active site
326424009746	Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482
326424009747	Putative regulatory, ligand-binding protein related to C-terminal domains of K+ channels [Inorganic ion transport and metabolism]; Region: COG0490
326424009748	Anion permease ArsB/NhaD.  These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life.  A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl15357
326424009749	Putative transmembrane protein (PGPGW); Region: PGPGW; cl09870
326424009750	Glucoamylase and related glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: SGA1; COG3387
326424009751	Glycosyl hydrolases family 15; Region: Glyco_hydro_15; pfam00723
326424009752	hydroxyglutarate oxidase; Provisional; Region: PRK11728
326424009753	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
326424009754	Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520
326424009755	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
326424009756	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
326424009757	catalytic residue [active]
326424009758	Domain of unknown function (DUF222); Region: DUF222; pfam02720
326424009759	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
326424009760	active site
326424009761	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
326424009762	Helix-turn-helix domains; Region: HTH; cl00088
326424009763	dimerization interface [polypeptide binding]; other site
326424009764	DNA binding residues [nucleotide binding]
326424009765	pyruvate kinase; Provisional; Region: PRK06247
326424009766	Pyruvate kinase (PK):  Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl09155
326424009767	domain interfaces; other site
326424009768	active site
326424009769	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
326424009770	ABC transporter transmembrane region; Region: ABC_membrane; cl00549
326424009771	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
326424009772	Walker A/P-loop; other site
326424009773	ATP binding site [chemical binding]; other site
326424009774	Q-loop/lid; other site
326424009775	ABC transporter signature motif; other site
326424009776	Walker B; other site
326424009777	D-loop; other site
326424009778	H-loop/switch region; other site
326424009779	Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053
326424009780	Cation efflux family; Region: Cation_efflux; cl00316
326424009781	ATP-binding cassette protein, ChvD family; Region: ABC_ABC_ChvD; TIGR03719
326424009782	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
326424009783	G1 box; other site
326424009784	GTP/Mg2+ binding site [chemical binding]; other site
326424009785	Putative exonuclease SbcCD, C subunit; Region: SbcCD_C; pfam13558
326424009786	Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305
326424009787	Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379
326424009788	Transglutaminase-like superfamily; Region: Transglut_core; cl10469
326424009789	A predicted alpha-helical domain with a conserved ER motif; Region: Alpha-E; cl00980
326424009790	A circularly permuted ATPgrasp; Region: CP_ATPgrasp_1; cl00503
326424009791	dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088
326424009792	dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246
326424009793	NAD binding site [chemical binding]; other site
326424009794	substrate binding site [chemical binding]; other site
326424009795	homodimer interface [polypeptide binding]; other site
326424009796	active site
326424009797	glycogen synthase, Corynebacterium family; Region: glgA_Coryne; TIGR02149
326424009798	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
326424009799	glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK00844
326424009800	ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508
326424009801	oligomer interface; other site
326424009802	ligand binding site; other site
326424009803	Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651
326424009804	dimer interface [polypeptide binding]; other site
326424009805	N-terminal domain interface [polypeptide binding]; other site
326424009806	sulfate 1 binding site; other site
326424009807	Protein of unknown function (DUF3995); Region: DUF3995; pfam13160
326424009808	Domain of unknown function DUF59; Region: DUF59; cl00941
326424009809	Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664
326424009810	trimerization site [polypeptide binding]; other site
326424009811	active site
326424009812	Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520
326424009813	Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453
326424009814	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
326424009815	catalytic residue [active]
326424009816	FeS assembly ATPase SufC; Region: sufC; TIGR01978
326424009817	ABC-type transport system involved in Fe-S cluster assembly, ATPase component.  Biosynthesis of iron-sulfur clusters (Fe-S) depends on multiprotein systems.  The SUF system of E. coli and Erwinia chrysanthemi is important for Fe-S biogenesis under...; Region: ABC_FeS_Assembly; cd03217
326424009818	Walker A/P-loop; other site
326424009819	ATP binding site [chemical binding]; other site
326424009820	Q-loop/lid; other site
326424009821	ABC transporter signature motif; other site
326424009822	Walker B; other site
326424009823	D-loop; other site
326424009824	H-loop/switch region; other site
326424009825	Rieske non-heme iron oxygenase (RO) family, Rieske ferredoxin component; composed of the Rieske ferredoxin component of some three-component RO systems including biphenyl dioxygenase (BPDO) and carbazole 1,9a-dioxygenase (CARDO). The RO family comprise a...; Region: Rieske_RO_ferredoxin; cd03528
326424009826	[2Fe-2S] cluster binding site [ion binding]; other site
326424009827	Uncharacterized protein family (UPF0051); Region: UPF0051; cl03223
326424009828	Uncharacterized protein family (UPF0051); Region: UPF0051; cl03223
326424009829	FeS assembly protein SufB; Region: sufB; TIGR01980
326424009830	Predicted transcriptional regulator [Transcription]; Region: COG2345
326424009831	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
326424009832	putative DNA binding site [nucleotide binding]; other site
326424009833	putative Zn2+ binding site [ion binding]; other site
326424009834	Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786
326424009835	glycerol kinase; Provisional; Region: glpK; PRK00047
326424009836	N- and C-terminal domain interface [polypeptide binding]; other site
326424009837	active site
326424009838	MgATP binding site [chemical binding]; other site
326424009839	catalytic site [active]
326424009840	metal binding site [ion binding]; metal-binding site
326424009841	glycerol binding site [chemical binding]; other site
326424009842	homotetramer interface [polypeptide binding]; other site
326424009843	homodimer interface [polypeptide binding]; other site
326424009844	FBP binding site [chemical binding]; other site
326424009845	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761
326424009846	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
326424009847	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
326424009848	Walker A/P-loop; other site
326424009849	ATP binding site [chemical binding]; other site
326424009850	Q-loop/lid; other site
326424009851	ABC transporter signature motif; other site
326424009852	Walker B; other site
326424009853	D-loop; other site
326424009854	H-loop/switch region; other site
326424009855	ABC-2 type transporter; Region: ABC2_membrane; cl11417
326424009856	Cytochrome oxidase assembly protein; Region: COX15-CtaA; cl15852
326424009857	UV excision repair protein Rad23; Region: rad23; TIGR00601
326424009858	Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381
326424009859	UbiA prenyltransferase family; Region: UbiA; cl00337
326424009860	Transaldolase-like proteins from plants and bacteria; Region: Transaldolase_like; cd00955
326424009861	putative active site [active]
326424009862	transaldolase; Provisional; Region: PRK03903
326424009863	catalytic residue [active]
326424009864	glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722
326424009865	Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479
326424009866	Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781
326424009867	Glucose-6-phosphate dehydrogenase subunit; Region: OpcA_G6PD_assem; cl01359
326424009868	6PGL: 6-Phosphogluconolactonase (6PGL) subfamily; 6PGL catalyzes the second step of the oxidative phase of the pentose phosphate pathway, the hydrolyzation of 6-phosphoglucono-1,5-lactone (delta form) to 6-phosphogluconate. 6PGL is thought to guard...; Region: 6PGL; cd01400
326424009869	putative active site [active]
326424009870	Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396
326424009871	Short C-terminal domain; Region: SHOCT; cl01373
326424009872	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
326424009873	Catalytic domain of Protein Kinases; Region: PKc; cd00180
326424009874	active site
326424009875	ATP binding site [chemical binding]; other site
326424009876	substrate binding site [chemical binding]; other site
326424009877	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
326424009878	substrate binding site [chemical binding]; other site
326424009879	activation loop (A-loop); other site
326424009880	activation loop (A-loop); other site
326424009881	Domain of unknown function (DUF4109); Region: DUF4109; pfam13397
326424009882	The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709
326424009883	Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311
326424009884	substrate binding site [chemical binding]; other site
326424009885	dimer interface [polypeptide binding]; other site
326424009886	catalytic triad [active]
326424009887	Phosphoglycerate kinase; Region: PGK; pfam00162
326424009888	Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cl00198
326424009889	substrate binding site [chemical binding]; other site
326424009890	hinge regions; other site
326424009891	ADP binding site [chemical binding]; other site
326424009892	catalytic site [active]
326424009893	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
326424009894	glyceraldehyde-3-phosphate dehydrogenase, type I; Region: GAPDH-I; TIGR01534
326424009895	Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; cl15856
326424009896	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1481
326424009897	Sporulation Regulator WhiA N terminal; Region: WhiA_N; pfam10298
326424009898	family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187
326424009899	Uncharacterized protein family UPF0052; Region: UPF0052; pfam01933
326424009900	phosphate binding site [ion binding]; other site
326424009901	putative substrate binding pocket [chemical binding]; other site
326424009902	dimer interface [polypeptide binding]; other site
326424009903	P-loop ATPase protein family; Region: ATP_bind_2; cl15794
326424009904	Predicted P-loop-containing kinase [General function prediction only]; Region: COG1660
326424009905	excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558
326424009906	Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434
326424009907	GIY-YIG motif/motif A; other site
326424009908	active site
326424009909	catalytic site [active]
326424009910	putative DNA binding site [nucleotide binding]; other site
326424009911	metal binding site [ion binding]; metal-binding site
326424009912	UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459
326424009913	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786
326424009914	Streptomyces sporulation and cell division protein, SsgA; Region: SsgA; pfam04686
326424009915	The excision repair protein UvrA domain I; Nucleotide excision repair in eubacteria is a process that repairs DNA damage by the removal of a 12-13-mer oligonucleotide containing the lesion.  Recognition and cleavage of the damaged DNA is a multistep...; Region: ABC_UvrA_I; cd03270
326424009916	excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349
326424009917	The excision repair protein UvrA domain I; Nucleotide excision repair in eubacteria is a process that repairs DNA damage by the removal of a 12-13-mer oligonucleotide containing the lesion.  Recognition and cleavage of the damaged DNA is a multistep...; Region: ABC_UvrA_I; cd03270
326424009918	The excision repair protein UvrA domain II; Nucleotide excision repair in eubacteria is a process that repairs DNA damage by the removal of a 12-13-mer oligonucleotide containing the lesion.  Recognition and cleavage of the damaged DNA is a multistep...; Region: ABC_UvrA_II; cd03271
326424009919	Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446
326424009920	Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cl00161
326424009921	Catalytic domain of Protein Kinases; Region: PKc; cd00180
326424009922	active site
326424009923	ATP binding site [chemical binding]; other site
326424009924	substrate binding site [chemical binding]; other site
326424009925	activation loop (A-loop); other site
326424009926	translocation protein TolB; Provisional; Region: tolB; PRK04792
326424009927	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200
326424009928	structural tetrad; other site
326424009929	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
326424009930	Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695
326424009931	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
326424009932	active site
326424009933	Helix-turn-helix domains; Region: HTH; cl00088
326424009934	WYL domain; Region: WYL; cl14852
326424009935	Integral membrane protein TerC family; Region: TerC; cl10468
326424009936	Helix-turn-helix domains; Region: HTH; cl00088
326424009937	excinuclease ABC subunit B; Provisional; Region: PRK05298
326424009938	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
326424009939	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
326424009940	nucleotide binding region [chemical binding]; other site
326424009941	ATP-binding site [chemical binding]; other site
326424009942	Ultra-violet resistance protein B; Region: UvrB; pfam12344
326424009943	UvrB/uvrC motif; Region: UVR; pfam02151
326424009944	Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237
326424009945	Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022
326424009946	CoA-binding site [chemical binding]; other site
326424009947	ATP-binding [chemical binding]; other site
326424009948	Peptidase M4 family includes thermolysin, protealysin, aureolysin and neutral protease; Region: M4_neutral_protease; cd09597
326424009949	active site
326424009950	Zn binding site [ion binding]; other site
326424009951	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
326424009952	metal binding site [ion binding]; metal-binding site
326424009953	active site
326424009954	I-site; other site
326424009955	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
326424009956	DNA polymerase I; Provisional; Region: PRK05755
326424009957	PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859
326424009958	active site
326424009959	metal binding site 1 [ion binding]; metal-binding site
326424009960	putative 5' ssDNA interaction site; other site
326424009961	metal binding site 3; metal-binding site
326424009962	metal binding site 2 [ion binding]; metal-binding site
326424009963	H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898
326424009964	putative DNA binding site [nucleotide binding]; other site
326424009965	putative metal binding site [ion binding]; other site
326424009966	inactive DEDDy 3'-5' exonuclease domain of Bacillus stearothermophilus DNA polymerase I and similar family-A DNA polymerases; Region: DNA_polA_I_Bacillus_like_exo; cd06140
326424009967	Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637
326424009968	active site
326424009969	DNA binding site [nucleotide binding]
326424009970	catalytic site [active]
326424009971	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
326424009972	CoenzymeA binding site [chemical binding]; other site
326424009973	subunit interaction site [polypeptide binding]; other site
326424009974	PHB binding site; other site
326424009975	ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683
326424009976	Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342
326424009977	dimerization interface [polypeptide binding]; other site
326424009978	ligand binding site [chemical binding]; other site
326424009979	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
326424009980	Response regulator with putative antiterminator output domain [Signal transduction mechanisms]; Region: AmiR; COG3707
326424009981	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
326424009982	active site
326424009983	phosphorylation site [posttranslational modification]
326424009984	intermolecular recognition site; other site
326424009985	dimerization interface [polypeptide binding]; other site
326424009986	ANTAR domain; Region: ANTAR; cl04297
326424009987	Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961
326424009988	Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338
326424009989	catalytic residues [active]
326424009990	catalytic nucleophile [active]
326424009991	preprotein translocase subunit SecA; Reviewed; Region: secA; PRK12898
326424009992	Recombinase; Region: Recombinase; pfam07508
326424009993	Integrase core domain; Region: rve; cl01316
326424009994	Integrase core domain; Region: rve_3; cl15866
326424009995	DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182
326424009996	DNA binding site [nucleotide binding]
326424009997	Int/Topo IB signature motif; other site
326424009998	active site
326424009999	catalytic residues [active]
326424010000	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
326424010001	short chain dehydrogenase; Provisional; Region: PRK06523
326424010002	classical (c) SDRs; Region: SDR_c; cd05233
326424010003	NAD(P) binding site [chemical binding]; other site
326424010004	active site
326424010005	2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiH; COG0654
326424010006	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
326424010007	FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277
326424010008	FAD binding domain; Region: FAD_binding_4; pfam01565
326424010009	Berberine and berberine like; Region: BBE; pfam08031
326424010010	Cupin domain; Region: Cupin_2; cl09118
326424010011	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
326424010012	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632
326424010013	Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872
326424010014	active site
326424010015	NAD binding site [chemical binding]; other site
326424010016	metal binding site [ion binding]; metal-binding site
326424010017	3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616
326424010018	inhibitor-cofactor binding pocket; inhibition site
326424010019	pyridoxal 5'-phosphate binding site [chemical binding]; other site
326424010020	catalytic residue [active]
326424010021	pyranose oxidase; Region: pyranose_ox; TIGR02462
326424010022	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
326424010023	GMC oxidoreductase; Region: GMC_oxred_C; pfam05199
326424010024	Cupin domain; Region: Cupin_2; cl09118
326424010025	Cupin domain; Region: Cupin_2; cl09118
326424010026	putative allantoin catabolism protein; Region: ura-cupin; TIGR03214
326424010027	Cupin domain; Region: Cupin_2; cl09118
326424010028	Cupin domain; Region: Cupin_2; cl09118
326424010029	Phosphopantetheine attachment site; Region: PP-binding; cl09936
326424010030	Peptide arylation enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntE; COG1021
326424010031	AMP-binding enzyme; Region: AMP-binding; cl15778
326424010032	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
326424010033	'initiating' condensing enzymes are a subclass of decarboxylating condensing enzymes, including beta-ketoacyl [ACP] synthase, type III and polyketide synthases, type III, which include chalcone synthase and related enzymes. They are characterized by the...; Region: init_cond_enzymes; cd00827
326424010034	3-oxoacyl-[acyl-carrier-protein]; Region: FabH; COG0332
326424010035	dimer interface [polypeptide binding]; other site
326424010036	active site
326424010037	salicylate synthase MbtI; Reviewed; Region: PRK07912
326424010038	chorismate binding enzyme; Region: Chorismate_bind; cl10555
326424010039	Winged helix-turn helix; Region: HTH_29; pfam13551
326424010040	Winged helix-turn helix; Region: HTH_33; pfam13592
326424010041	Integrase core domain; Region: rve; cl01316
326424010042	probable F420-dependent oxidoreductase, MSMEG_2906 family; Region: F420_MSMEG_2906; TIGR03856
326424010043	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786
326424010044	hypothetical protein; Provisional; Region: PRK07206
326424010045	ATP-grasp domain; Region: ATP-grasp_4; cl03087
326424010046	A circularly permuted ATPgrasp; Region: CP_ATPgrasp_1; cl00503
326424010047	Acetylornithine deacetylase/Succinyl-diaminopimelate desuccinylase and related deacylases [Amino acid transport and metabolism]; Region: ArgE; COG0624
326424010048	M20 Peptidase actinobacterial DapE encoded N-succinyl-L,L-diaminopimelic acid desuccinylase; Region: M20_DapE_actinobac; cd05647
326424010049	metal binding site [ion binding]; metal-binding site
326424010050	putative dimer interface [polypeptide binding]; other site
326424010051	H+ Antiporter protein; Region: 2A0121; TIGR00900
326424010052	H+ Antiporter protein; Region: 2A0121; TIGR00900
326424010053	Demethylmenaquinone methyltransferase; Region: Methyltransf_6; cl00480
326424010054	A circularly permuted ATPgrasp; Region: CP_ATPgrasp_1; cl00503
326424010055	PyridoxaL 5'-Phosphate Dependent Enzymes class IV (PLPDE_IV). This D-amino acid superfamily, one of five classes of PLPDE, consists of branched-chain amino acid aminotransferases (BCAT), D-amino acid transferases (DAAT), and 4-amino-4-deoxychorismate...; Region: PLPDE_IV; cd00449
326424010056	homodimer interface [polypeptide binding]; other site
326424010057	substrate-cofactor binding pocket; other site
326424010058	pyridoxal 5'-phosphate binding site [chemical binding]; other site
326424010059	catalytic residue [active]
326424010060	Heme oxygenase catalyzes the rate limiting step in the degradation of heme to bilirubin, it is essential for recycling of iron from heme. Heme is used as a substrate and cofactor for its own degradation to biliverdin, iron, and carbon monoxide. This...; Region: HemeO; cl15243
326424010061	DRE-TIM metallolyase superfamily; Region: DRE_TIM_metallolyase; cl07974
326424010062	active site
326424010063	metal binding site [ion binding]; metal-binding site
326424010064	Integrase core domain; Region: rve; cl01316
326424010065	Catalytic domain of Protein Kinases; Region: PKc; cd00180
326424010066	active site
326424010067	ATP binding site [chemical binding]; other site
326424010068	substrate binding site [chemical binding]; other site
326424010069	activation loop (A-loop); other site
326424010070	haloacid dehalogenase-like hydrolase family protein; Region: PLN02919
326424010071	NHL repeat; Region: NHL; pfam01436
326424010072	haloacid dehalogenase-like hydrolase family protein; Region: PLN02919
326424010073	NHL repeat; Region: NHL; pfam01436
326424010074	NHL repeat; Region: NHL; pfam01436
326424010075	Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804
326424010076	CoA-transferase family III; Region: CoA_transf_3; pfam02515
326424010077	CoA-transferase family III; Region: CoA_transf_3; pfam02515
326424010078	Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cl02788
326424010079	catalytic residues [active]
326424010080	Transcriptional regulators [Transcription]; Region: PhnF; COG2188
326424010081	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
326424010082	DNA-binding site [nucleotide binding]; DNA binding site
326424010083	UTRA domain; Region: UTRA; cl01230
326424010084	Tryptophan synthase-beta:  Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446
326424010085	Pyridoxal-phosphate dependent enzyme; Region: PALP; pfam00291
326424010086	pyridoxal 5'-phosphate binding site [chemical binding]; other site
326424010087	catalytic residue [active]
326424010088	Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724
326424010089	substrate binding site [chemical binding]; other site
326424010090	active site
326424010091	catalytic residues [active]
326424010092	heterodimer interface [polypeptide binding]; other site
326424010093	carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294
326424010094	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
326424010095	ATP-grasp domain; Region: ATP-grasp_4; cl03087
326424010096	Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787
326424010097	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
326424010098	ATP-grasp domain; Region: ATP-grasp_4; cl03087
326424010099	Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424
326424010100	IMP binding site; other site
326424010101	dimer interface [polypeptide binding]; other site
326424010102	interdomain contacts; other site
326424010103	partial ornithine binding site; other site
326424010104	carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564
326424010105	Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; cl03056
326424010106	Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744
326424010107	catalytic site [active]
326424010108	subunit interface [polypeptide binding]; other site
326424010109	ATP-grasp domain; Region: ATP-grasp_4; cl03087
326424010110	argininosuccinate lyase; Provisional; Region: PRK02186
326424010111	ATP-grasp domain; Region: ATP-grasp_4; cl03087
326424010112	Clavaminic acid synthetase (CAS) -like;  CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cl00184
326424010113	substrate binding pocket [chemical binding]; other site
326424010114	active site
326424010115	iron coordination sites [ion binding]; other site
326424010116	Predicted carbamoyl transferase, NodU family [Posttranslational modification, protein turnover, chaperones]; Region: COG2192
326424010117	Carbamoyltransferase; Region: CmcH_NodU; pfam02543
326424010118	SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053
326424010119	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
326424010120	Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221
326424010121	NAD(P) binding site [chemical binding]; other site
326424010122	active site
326424010123	LysE type translocator; Region: LysE; cl00565
326424010124	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167
326424010125	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
326424010126	DNA-binding site [nucleotide binding]; DNA binding site
326424010127	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
326424010128	pyridoxal 5'-phosphate binding site [chemical binding]; other site
326424010129	homodimer interface [polypeptide binding]; other site
326424010130	catalytic residue [active]
326424010131	S-adenosyl methyltransferase; Region: Methyltransf_19; pfam04672
326424010132	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
326424010133	S-adenosylmethionine binding site [chemical binding]; other site
326424010134	Condensation domain; Region: Condensation; pfam00668
326424010135	The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509
326424010136	active site 2 [active]
326424010137	The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509
326424010138	active site 2 [active]
326424010139	active site 1 [active]
326424010140	3-ketoacyl-(acyl-carrier-protein) reductase; Reviewed; Region: PRK12826
326424010141	classical (c) SDRs; Region: SDR_c; cd05233
326424010142	NAD(P) binding site [chemical binding]; other site
326424010143	active site
326424010144	enoyl-CoA hydratase; Provisional; Region: PRK06495
326424010145	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
326424010146	substrate binding site [chemical binding]; other site
326424010147	oxyanion hole (OAH) forming residues; other site
326424010148	trimer interface [polypeptide binding]; other site
326424010149	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cl15762
326424010150	3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565
326424010151	classical (c) SDRs; Region: SDR_c; cd05233
326424010152	NAD(P) binding site [chemical binding]; other site
326424010153	active site
326424010154	enoyl-CoA hydratase; Provisional; Region: PRK06210
326424010155	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
326424010156	substrate binding site [chemical binding]; other site
326424010157	oxyanion hole (OAH) forming residues; other site
326424010158	trimer interface [polypeptide binding]; other site
326424010159	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cl15762
326424010160	DinB superfamily; Region: DinB_2; pfam12867
326424010161	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
326424010162	Helix-turn-helix domains; Region: HTH; cl00088
326424010163	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557
326424010164	classical (c) SDRs; Region: SDR_c; cd05233
326424010165	NAD(P) binding site [chemical binding]; other site
326424010166	active site
326424010167	Protein of unknown function (DUF1470); Region: DUF1470; pfam07336
326424010168	CGNR zinc finger; Region: zf-CGNR; pfam11706
326424010169	Cupin domain; Region: Cupin_2; cl09118
326424010170	TIR domain; Region: TIR_2; cl15770
326424010171	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
326424010172	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
326424010173	Walker A/P-loop; other site
326424010174	ATP binding site [chemical binding]; other site
326424010175	Q-loop/lid; other site
326424010176	ABC transporter signature motif; other site
326424010177	Walker B; other site
326424010178	D-loop; other site
326424010179	H-loop/switch region; other site
326424010180	Superfamily I DNA and RNA helicases [General function prediction only]; Region: COG3973
326424010181	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
326424010182	Superfamily I DNA and RNA helicases [General function prediction only]; Region: COG3973
326424010183	Family description; Region: UvrD_C_2; cl15862
326424010184	Sulfate transporter family; Region: Sulfate_transp; cl15842
326424010185	Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA; cl00391
326424010186	active site clefts [active]
326424010187	zinc binding site [ion binding]; other site
326424010188	dimer interface [polypeptide binding]; other site
326424010189	Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA; cl00391
326424010190	zinc binding site [ion binding]; other site
326424010191	Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl15769
326424010192	Predicted oxidoreductases (related to aryl-alcohol dehydrogenases) [Energy production and conversion]; Region: Tas; COG0667
326424010193	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
326424010194	active site
326424010195	catalytic tetrad [active]
326424010196	Protein of unknown function (DUF1003); Region: DUF1003; cl01831
326424010197	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
326424010198	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
326424010199	Walker A/P-loop; other site
326424010200	ATP binding site [chemical binding]; other site
326424010201	Q-loop/lid; other site
326424010202	ABC transporter signature motif; other site
326424010203	Walker B; other site
326424010204	D-loop; other site
326424010205	H-loop/switch region; other site
326424010206	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
326424010207	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
326424010208	active site
326424010209	phosphorylation site [posttranslational modification]
326424010210	intermolecular recognition site; other site
326424010211	dimerization interface [polypeptide binding]; other site
326424010212	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
326424010213	dimerization interface [polypeptide binding]; other site
326424010214	DNA binding residues [nucleotide binding]
326424010215	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075
326424010216	Predicted ATPase [General function prediction only]; Region: COG3899
326424010217	clavulanic acid dehydrogenase (CAD), classical (c) SDR; Region: CAD_SDR_c; cd08934
326424010218	NADP binding site [chemical binding]; other site
326424010219	homotetramer interface [polypeptide binding]; other site
326424010220	homodimer interface [polypeptide binding]; other site
326424010221	active site
326424010222	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
326424010223	S-adenosylmethionine binding site [chemical binding]; other site
326424010224	probable F420-dependent oxidoreductase, MSMEG_2516 family; Region: F420_MSMEG_2516; TIGR03621
326424010225	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
326424010226	YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259
326424010227	putative active site [active]
326424010228	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
326424010229	RNA binding surface [nucleotide binding]; other site
326424010230	Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446
326424010231	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
326424010232	Major Facilitator Superfamily; Region: MFS_1; pfam07690
326424010233	putative substrate translocation pore; other site
326424010234	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
326424010235	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
326424010236	Ligand Binding Site [chemical binding]; other site
326424010237	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
326424010238	Ligand Binding Site [chemical binding]; other site
326424010239	GAF domain; Region: GAF; cl15785
326424010240	GAF domain; Region: GAF; cl15785
326424010241	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585
326424010242	Histidine kinase; Region: HisKA_3; pfam07730
326424010243	Predicted membrane protein [Function unknown]; Region: COG1511
326424010244	mycofactocin system transcriptional regulator; Region: mycofact_TetR; TIGR03968
326424010245	Helix-turn-helix domains; Region: HTH; cl00088
326424010246	2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiH; COG0654
326424010247	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
326424010248	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
326424010249	Helix-turn-helix domains; Region: HTH; cl00088
326424010250	Domain of unknown function (DUF427); Region: DUF427; cl00998
326424010251	Domain of unknown function (DUF427); Region: DUF427; cl00998
326424010252	Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cl00120
326424010253	Zn-dependent alcohol dehydrogenases, class III [Energy production and conversion]; Region: AdhC; COG1062
326424010254	Benzyl alcohol dehydrogenase; Region: benzyl_alcohol_DH; cd08278
326424010255	catalytic Zn binding site [ion binding]; other site
326424010256	NAD binding site [chemical binding]; other site
326424010257	structural Zn binding site [ion binding]; other site
326424010258	Pseudomonas putida Aldehyde dehydrogenase AlkH-like; Region: ALDH_AlkH-like; cd07134
326424010259	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
326424010260	NAD(P) binding site [chemical binding]; other site
326424010261	catalytic residues [active]
326424010262	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
326424010263	extended (e) SDRs; Region: SDR_e; cd08946
326424010264	NAD(P) binding site [chemical binding]; other site
326424010265	active site
326424010266	substrate binding site [chemical binding]; other site
326424010267	Helix-turn-helix domains; Region: HTH; cl00088
326424010268	pca operon transcription factor PcaQ; Region: TF_pcaQ; TIGR02424
326424010269	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
326424010270	Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581
326424010271	LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399
326424010272	Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804
326424010273	CoA-transferase family III; Region: CoA_transf_3; pfam02515
326424010274	Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804
326424010275	CoA-transferase family III; Region: CoA_transf_3; pfam02515
326424010276	acetyl-CoA acetyltransferase; Validated; Region: PRK08257
326424010277	Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938
326424010278	active site
326424010279	enoyl-CoA hydratase; Provisional; Region: PRK06494
326424010280	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
326424010281	substrate binding site [chemical binding]; other site
326424010282	oxyanion hole (OAH) forming residues; other site
326424010283	trimer interface [polypeptide binding]; other site
326424010284	enoyl-CoA hydratase; Provisional; Region: PRK06688
326424010285	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
326424010286	substrate binding site [chemical binding]; other site
326424010287	oxyanion hole (OAH) forming residues; other site
326424010288	trimer interface [polypeptide binding]; other site
326424010289	Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat2; cd03445
326424010290	active site
326424010291	Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat1; cd03444
326424010292	catalytic triad [active]
326424010293	dimer interface [polypeptide binding]; other site
326424010294	Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804
326424010295	CoA-transferase family III; Region: CoA_transf_3; pfam02515
326424010296	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
326424010297	Acyl-CoA dehydrogenase; Region: ACAD; cd00567
326424010298	active site
326424010299	Phosphotransferase enzyme family; Region: APH; pfam01636
326424010300	Acyl-CoA dehydrogenase (ACAD) 10 and 11, N-terminal domain, and similar proteins. This subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: ACAD10_11_like; cd05154
326424010301	putative active site [active]
326424010302	putative substrate binding site [chemical binding]; other site
326424010303	ATP binding site [chemical binding]; other site
326424010304	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cl15762
326424010305	enoyl-CoA hydratase; Provisional; Region: PRK06142
326424010306	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
326424010307	substrate binding site [chemical binding]; other site
326424010308	oxyanion hole (OAH) forming residues; other site
326424010309	trimer interface [polypeptide binding]; other site
326424010310	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
326424010311	NAD(P) binding site [chemical binding]; other site
326424010312	active site
326424010313	probable F420-dependent oxidoreductase, Rv3520c family; Region: F420_Rv3520c; TIGR03559
326424010314	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
326424010315	N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097
326424010316	enoyl-CoA hydratase; Provisional; Region: PRK06190
326424010317	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
326424010318	substrate binding site [chemical binding]; other site
326424010319	oxyanion hole (OAH) forming residues; other site
326424010320	trimer interface [polypeptide binding]; other site
326424010321	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
326424010322	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
326424010323	active site
326424010324	catalytic tetrad [active]
326424010325	17hydroxysteroid dehydrogenase type 10 (HSD10)-like, classical (c) SDRs; Region: HSD10-like_SDR_c; cd05371
326424010326	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557
326424010327	NAD binding site [chemical binding]; other site
326424010328	homotetramer interface [polypeptide binding]; other site
326424010329	homodimer interface [polypeptide binding]; other site
326424010330	active site
326424010331	OpgC protein; Region: OpgC_C; cl00792
326424010332	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
326424010333	CoenzymeA binding site [chemical binding]; other site
326424010334	subunit interaction site [polypeptide binding]; other site
326424010335	PHB binding site; other site
326424010336	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
326424010337	CoenzymeA binding site [chemical binding]; other site
326424010338	subunit interaction site [polypeptide binding]; other site
326424010339	PHB binding site; other site
326424010340	Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cl00120
326424010341	Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600
326424010342	Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789
326424010343	DNA binding residues [nucleotide binding]
326424010344	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
326424010345	putative substrate translocation pore; other site
326424010346	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
326424010347	putative substrate translocation pore; other site
326424010348	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
326424010349	Helix-turn-helix domains; Region: HTH; cl00088
326424010350	This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784
326424010351	active site
326424010352	TDP-binding site; other site
326424010353	acceptor substrate-binding pocket; other site
326424010354	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
326424010355	putative FMN-dependent luciferase-like monooxygenase, KPN_01858 family; Region: LLM_KPN_01858; TIGR04027
326424010356	hypothetical protein; Provisional; Region: PRK06126
326424010357	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
326424010358	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
326424010359	FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860
326424010360	nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095
326424010361	active site
326424010362	non-prolyl cis peptide bond; other site
326424010363	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124
326424010364	The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE).  The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257
326424010365	Walker A/P-loop; other site
326424010366	ATP binding site [chemical binding]; other site
326424010367	Q-loop/lid; other site
326424010368	ABC transporter signature motif; other site
326424010369	Walker B; other site
326424010370	D-loop; other site
326424010371	H-loop/switch region; other site
326424010372	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
326424010373	nickel import ATP-binding protein NikD; Region: nickel_nikD; TIGR02770
326424010374	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
326424010375	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173
326424010376	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
326424010377	dimer interface [polypeptide binding]; other site
326424010378	conserved gate region; other site
326424010379	ABC-ATPase subunit interface; other site
326424010380	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
326424010381	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
326424010382	dimer interface [polypeptide binding]; other site
326424010383	conserved gate region; other site
326424010384	putative PBP binding loops; other site
326424010385	ABC-ATPase subunit interface; other site
326424010386	The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_9; cd08496
326424010387	Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496
326424010388	nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095
326424010389	FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860
326424010390	active site
326424010391	non-prolyl cis peptide bond; other site
326424010392	Helix-turn-helix domains; Region: HTH; cl00088
326424010393	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
326424010394	probable F420-dependent oxidoreductase, Rv1855c family; Region: F420_Rv1855c; TIGR03560
326424010395	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
326424010396	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
326424010397	Helix-turn-helix domains; Region: HTH; cl00088
326424010398	Protein of unknown function (DUF2889); Region: DUF2889; pfam11136
326424010399	CoA-transferase family III; Region: CoA_transf_3; pfam02515
326424010400	Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804
326424010401	CoA-transferase family III; Region: CoA_transf_3; pfam02515
326424010402	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
326424010403	This family of ATP-binding proteins belongs to a multisubunit transporter involved in drug resistance (BcrA and DrrA), nodulation, lipid transport, and lantibiotic immunity.  In bacteria and archaea, these transporters usually include an ATP-binding...; Region: ABC_DR_subfamily_A; cd03230
326424010404	Walker A/P-loop; other site
326424010405	ATP binding site [chemical binding]; other site
326424010406	Q-loop/lid; other site
326424010407	ABC transporter signature motif; other site
326424010408	Walker B; other site
326424010409	D-loop; other site
326424010410	H-loop/switch region; other site
326424010411	ABC-2 type transporter; Region: ABC2_membrane; cl11417
326424010412	Superfamily I DNA and RNA helicases [General function prediction only]; Region: COG3973
326424010413	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
326424010414	Superfamily I DNA and RNA helicases [General function prediction only]; Region: COG3973
326424010415	Family description; Region: UvrD_C_2; cl15862
326424010416	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585
326424010417	Histidine kinase; Region: HisKA_3; pfam07730
326424010418	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
326424010419	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
326424010420	active site
326424010421	phosphorylation site [posttranslational modification]
326424010422	intermolecular recognition site; other site
326424010423	dimerization interface [polypeptide binding]; other site
326424010424	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
326424010425	DNA binding residues [nucleotide binding]
326424010426	dimerization interface [polypeptide binding]; other site
326424010427	Golgi phosphoprotein 3 (GPP34); Region: GPP34; pfam05719
326424010428	Protein of unknown function (DUF3311); Region: DUF3311; pfam11755
326424010429	Sodium:solute symporter family; Region: SSF; cl00456
326424010430	PIN domain of the Pyrobaculum aerophilum Pae0151 and Pae2754 proteins and homologs; Region: PIN_Pae0151; cd09873
326424010431	homotetrameric interface [polypeptide binding]; other site
326424010432	putative active site [active]
326424010433	metal binding site [ion binding]; metal-binding site
326424010434	bifunctional SbtC-like/phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Provisional; Region: PRK13982
326424010435	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632
326424010436	active site
326424010437	M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886
326424010438	amidohydrolase; Region: amidohydrolases; TIGR01891
326424010439	metal binding site [ion binding]; metal-binding site
326424010440	dimer interface [polypeptide binding]; other site
326424010441	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
326424010442	sequence-specific DNA binding site [nucleotide binding]; other site
326424010443	salt bridge; other site
326424010444	Cupin domain; Region: Cupin_2; cl09118
326424010445	Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity. They also contain a...; Region: Nudix_Hydrolase_1; cd03674
326424010446	nudix motif; other site
326424010447	Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586
326424010448	SNARE associated Golgi protein; Region: SNARE_assoc; cl00429
326424010449	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
326424010450	NADH(P)-binding; Region: NAD_binding_10; pfam13460
326424010451	NAD(P) binding site [chemical binding]; other site
326424010452	active site
326424010453	Cupin domain; Region: Cupin_2; cl09118
326424010454	Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381
326424010455	formaldehyde dehydrogenase (FDH)-like; Region: FDH_like_ADH3; cd08287
326424010456	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
326424010457	catalytic Zn binding site [ion binding]; other site
326424010458	NAD(P) binding site [chemical binding]; other site
326424010459	structural Zn binding site [ion binding]; other site
326424010460	alkanesulfonate monooxygenase; Provisional; Region: PRK00719
326424010461	Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094
326424010462	active site
326424010463	dimer interface [polypeptide binding]; other site
326424010464	non-prolyl cis peptide bond; other site
326424010465	insertion regions; other site
326424010466	S-adenosyl methyltransferase; Region: Methyltransf_19; pfam04672
326424010467	nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095
326424010468	FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860
326424010469	active site
326424010470	non-prolyl cis peptide bond; other site
326424010471	nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095
326424010472	FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860
326424010473	active site
326424010474	non-prolyl cis peptide bond; other site
326424010475	putative FMN-dependent luciferase-like monooxygenase, KPN_01858 family; Region: LLM_KPN_01858; TIGR04027
326424010476	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
326424010477	The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE).  The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257
326424010478	nickel import ATP-binding protein NikD; Region: nickel_nikD; TIGR02770
326424010479	Walker A/P-loop; other site
326424010480	ATP binding site [chemical binding]; other site
326424010481	Q-loop/lid; other site
326424010482	ABC transporter signature motif; other site
326424010483	Walker B; other site
326424010484	D-loop; other site
326424010485	H-loop/switch region; other site
326424010486	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
326424010487	nickel import ATP-binding protein NikD; Region: nickel_nikD; TIGR02770
326424010488	The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE).  The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257
326424010489	Walker A/P-loop; other site
326424010490	ATP binding site [chemical binding]; other site
326424010491	Q-loop/lid; other site
326424010492	ABC transporter signature motif; other site
326424010493	Walker B; other site
326424010494	D-loop; other site
326424010495	H-loop/switch region; other site
326424010496	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173
326424010497	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427
326424010498	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427
326424010499	The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_6; cd08494
326424010500	Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496
326424010501	Isopenicillin N synthase and related dioxygenases [General function prediction only]; Region: PcbC; COG3491
326424010502	non-haem dioxygenase in morphine synthesis N-terminal; Region: DIOX_N; cl14733
326424010503	2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy; cl15773
326424010504	O-acetylhomoserine aminocarboxypropyltransferase; Validated; Region: PRK07812
326424010505	CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614
326424010506	homodimer interface [polypeptide binding]; other site
326424010507	substrate-cofactor binding pocket; other site
326424010508	pyridoxal 5'-phosphate binding site [chemical binding]; other site
326424010509	catalytic residue [active]
326424010510	Large-conductance mechanosensitive channel, MscL; Region: MscL; cl00860
326424010511	large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567
326424010512	S-adenosyl methyltransferase; Region: Methyltransf_19; pfam04672
326424010513	Leucine carboxyl methyltransferase; Region: LCM; cl01306
326424010514	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
326424010515	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
326424010516	NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604
326424010517	alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289
326424010518	putative NAD(P) binding site [chemical binding]; other site
326424010519	N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357
326424010520	hypothetical protein; Provisional; Region: PRK07906
326424010521	M20 Peptidase, carboxypeptidase yscS-like; Region: M20_yscS_like; cd05675
326424010522	putative metal binding site [ion binding]; other site
326424010523	Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381
326424010524	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
326424010525	PAS fold; Region: PAS_3; pfam08447
326424010526	putative active site [active]
326424010527	heme pocket [chemical binding]; other site
326424010528	GAF domain; Region: GAF_2; pfam13185
326424010529	GAF domain; Region: GAF; cl15785
326424010530	Signal transduction protein containing GAF and PtsI domains [Signal transduction mechanisms]; Region: PtsP; COG3605
326424010531	Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cl00120
326424010532	Transcriptional regulators [Transcription]; Region: FadR; COG2186
326424010533	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
326424010534	DNA-binding site [nucleotide binding]; DNA binding site
326424010535	FCD domain; Region: FCD; cl11656
326424010536	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
326424010537	substrate binding site [chemical binding]; other site
326424010538	oxyanion hole (OAH) forming residues; other site
326424010539	trimer interface [polypeptide binding]; other site
326424010540	DPG_synthase is involved in protein N-linked glycosylation; Region: DPG_synthase; cd04188
326424010541	Ligand binding site; other site
326424010542	Ligand binding site; other site
326424010543	Ligand binding site; other site
326424010544	Putative Catalytic site; other site
326424010545	DXD motif; other site
326424010546	Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl15769
326424010547	ATP-dependent transcriptional regulator [Transcription]; Region: MalT; COG2909
326424010548	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
326424010549	DNA binding residues [nucleotide binding]
326424010550	dimerization interface [polypeptide binding]; other site
326424010551	Periplasmic binding protein; Region: Peripla_BP_6; pfam13458
326424010552	Type I periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type active transport systems that are predicted to be involved in transport of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_7; cd06341
326424010553	putative ligand binding site [chemical binding]; other site
326424010554	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410
326424010555	LivF (TM1139) is part of the LIV-I bacterial ABC-type two-component transport system that imports neutral, branched-chain amino acids.  The  E. coli branched-chain amino acid transporter comprises a heterodimer of ABC transporters (LivF and LivG), a...; Region: ABC_TM1139_LivF_branched; cd03224
326424010556	Walker A/P-loop; other site
326424010557	ATP binding site [chemical binding]; other site
326424010558	Q-loop/lid; other site
326424010559	ABC transporter signature motif; other site
326424010560	Walker B; other site
326424010561	D-loop; other site
326424010562	H-loop/switch region; other site
326424010563	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
326424010564	TM-ABC transporter signature motif; other site
326424010565	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
326424010566	TM-ABC transporter signature motif; other site
326424010567	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411
326424010568	The Mj1267/LivG ABC transporter subfamily is involved in the transport of the hydrophobic amino acids leucine, isoleucine and valine.  MJ1267 is a branched-chain amino acid transporter with 29% similarity to both the LivF and LivG components of the E; Region: ABC_Mj1267_LivG_branched; cd03219
326424010569	Walker A/P-loop; other site
326424010570	ATP binding site [chemical binding]; other site
326424010571	Q-loop/lid; other site
326424010572	ABC transporter signature motif; other site
326424010573	Walker B; other site
326424010574	D-loop; other site
326424010575	H-loop/switch region; other site
326424010576	(R)-hydratase [(R)-specific enoyl-CoA hydratase]. Catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway.  The structure of the monomer includes a five-strand antiparallel...; Region: R_hydratase_like; cd03441
326424010577	active site
326424010578	catalytic site [active]
326424010579	The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509
326424010580	active site 2 [active]
326424010581	active site 1 [active]
326424010582	Periplasmic binding protein; Region: Peripla_BP_6; pfam13458
326424010583	Type I periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type active transport systems that are predicted to be involved in transport of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_7; cd06341
326424010584	putative ligand binding site [chemical binding]; other site
326424010585	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
326424010586	NAD(P) binding site [chemical binding]; other site
326424010587	active site
326424010588	Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771
326424010589	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
326424010590	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
326424010591	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
326424010592	active site
326424010593	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
326424010594	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
326424010595	active site
326424010596	Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318
326424010597	AMP-binding enzyme; Region: AMP-binding; cl15778
326424010598	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
326424010599	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
326424010600	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
326424010601	active site
326424010602	5,10-methylenetetrahydromethanopterin reductase; Region: F420_mer; TIGR03555
326424010603	N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097
326424010604	Transcriptional regulators [Transcription]; Region: FadR; COG2186
326424010605	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
326424010606	DNA-binding site [nucleotide binding]; DNA binding site
326424010607	FCD domain; Region: FCD; cl11656
326424010608	Rubredoxin-like zinc ribbon domain (DUF35_N); Region: DUF35_N; pfam12172
326424010609	DUF35 OB-fold domain; Region: DUF35; pfam01796
326424010610	lipid-transfer protein; Provisional; Region: PRK07855
326424010611	Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2  has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829
326424010612	active site
326424010613	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
326424010614	long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187
326424010615	AMP-binding enzyme; Region: AMP-binding; cl15778
326424010616	Helix-turn-helix domains; Region: HTH; cl00088
326424010617	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
326424010618	Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771
326424010619	Acyl-CoA dehydrogenase; Region: ACAD; cd00567
326424010620	active site
326424010621	Phosphotransferase enzyme family; Region: APH; pfam01636
326424010622	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
326424010623	nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095
326424010624	active site
326424010625	FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860
326424010626	non-prolyl cis peptide bond; other site
326424010627	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
326424010628	Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141
326424010629	Dienelactone hydrolase family; Region: DLH; pfam01738
326424010630	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
326424010631	Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeD; cd03379
326424010632	active site clefts [active]
326424010633	zinc binding site [ion binding]; other site
326424010634	dimer interface [polypeptide binding]; other site
326424010635	Helix-turn-helix domains; Region: HTH; cl00088
326424010636	NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604
326424010637	alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289
326424010638	putative NAD(P) binding site [chemical binding]; other site
326424010639	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
326424010640	S-adenosylmethionine binding site [chemical binding]; other site
326424010641	Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583
326424010642	amidase catalytic site [active]
326424010643	Zn binding residues [ion binding]; other site
326424010644	substrate binding site [chemical binding]; other site
326424010645	ChaB; Region: ChaB; cl01887
326424010646	Rho termination factor, N-terminal domain; Region: Rho_N; cl06505
326424010647	Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409
326424010648	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
326424010649	putative acyl-acceptor binding pocket; other site
326424010650	GAF domain; Region: GAF; cl15785
326424010651	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
326424010652	DNA binding residues [nucleotide binding]
326424010653	dimerization interface [polypeptide binding]; other site
326424010654	RecB family nuclease, putative, TM0106 family; Region: TIGR03491
326424010655	DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012
326424010656	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
326424010657	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
326424010658	Family description; Region: UvrD_C_2; cl15862
326424010659	N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357
326424010660	acetyl coenzyme A synthetase (ADP forming), alpha domain; Region: AcCoA-syn-alpha; TIGR02717
326424010661	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
326424010662	CoA-ligase; Region: Ligase_CoA; cl02894
326424010663	ATP-grasp domain; Region: ATP-grasp_4; cl03087
326424010664	prephenate dehydratase; Provisional; Region: PRK11899
326424010665	Prephenate dehydratase; Region: PDT; pfam00800
326424010666	C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905
326424010667	putative L-Phe binding site [chemical binding]; other site
326424010668	Na+/H+ antiporter 1; Region: Na_H_antiport_1; cl01133
326424010669	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
326424010670	Class II vitamin B12-dependent ribonucleotide reductase; Region: Ribonuc_red_2_N; pfam08471
326424010671	ribonucleoside-diphosphate reductase, adenosylcobalamin-dependent; Region: NrdJ_Z; TIGR02504
326424010672	Class II ribonucleotide reductase, dimeric form; Region: RNR_II_dimer; cd02888
326424010673	active site
326424010674	dimer interface [polypeptide binding]; other site
326424010675	effector binding site; other site
326424010676	Domain of unknown function (DUF222); Region: DUF222; pfam02720
326424010677	LamB/YcsF family; Region: LamB_YcsF; cl00664
326424010678	Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; cl00896
326424010679	Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; cl00896
326424010680	Allophanate hydrolase subunit 2; Region: AHS2; cl00865
326424010681	Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426
326424010682	putative active site [active]
326424010683	putative CoA binding site [chemical binding]; other site
326424010684	nudix motif; other site
326424010685	metal binding site [ion binding]; metal-binding site
326424010686	Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917
326424010687	NodB motif; other site
326424010688	active site
326424010689	catalytic site [active]
326424010690	metal binding site [ion binding]; metal-binding site
326424010691	Iron-sulfur binding ferredoxin reductase (FNR) proteins combine the FAD and NAD(P) binding regions of FNR with an iron-sulfur binding cluster domain. Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron...; Region: FNR_iron_sulfur_binding_3; cd06217
326424010692	FAD binding pocket [chemical binding]; other site
326424010693	FAD binding motif [chemical binding]; other site
326424010694	phosphate binding motif [ion binding]; other site
326424010695	beta-alpha-beta structure motif; other site
326424010696	NAD binding pocket [chemical binding]; other site
326424010697	bacterial and archael members of the sulfite oxidase (SO) family of molybdopterin binding domains. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and...; Region: arch_bact_SO_family_Moco; cd02109
326424010698	Moco binding site; other site
326424010699	metal coordination site [ion binding]; other site
326424010700	Transcriptional regulators [Transcription]; Region: FadR; COG2186
326424010701	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
326424010702	DNA-binding site [nucleotide binding]; DNA binding site
326424010703	Precorrin-3B methylase [Coenzyme metabolism]; Region: CobJ; cl00304
326424010704	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
326424010705	acyl-CoA synthetase; Validated; Region: PRK07787
326424010706	AMP-binding enzyme; Region: AMP-binding; cl15778
326424010707	AMP-binding enzyme; Region: AMP-binding; cl15778
326424010708	ABC transporter transmembrane region; Region: ABC_membrane; cl00549
326424010709	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
326424010710	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
326424010711	Walker A/P-loop; other site
326424010712	ATP binding site [chemical binding]; other site
326424010713	Q-loop/lid; other site
326424010714	ABC transporter signature motif; other site
326424010715	Walker B; other site
326424010716	D-loop; other site
326424010717	H-loop/switch region; other site
326424010718	Transglutaminase-like superfamily; Region: Transglut_core; cl10469
326424010719	Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which  binds to Adenosine nucleotide; Region: AANH_like; cl00292
326424010720	Bacterial transcriptional activator domain; Region: BTAD; pfam03704
326424010721	lysozyme_like domain.  This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222
326424010722	Putative peptidoglycan binding domain; Region: PG_binding_1; cl15437
326424010723	Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267
326424010724	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
326424010725	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
326424010726	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
326424010727	Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228
326424010728	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
326424010729	active site
326424010730	Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141
326424010731	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
326424010732	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
326424010733	S-adenosylmethionine synthetase; Validated; Region: PRK05250
326424010734	S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438
326424010735	S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772
326424010736	S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773
326424010737	Domain of unknown function (DUF309); Region: DUF309; cl00667
326424010738	acetyl-CoA acetyltransferase; Provisional; Region: PRK06504
326424010739	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
326424010740	dimer interface [polypeptide binding]; other site
326424010741	active site
326424010742	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
326424010743	Helix-turn-helix domains; Region: HTH; cl00088
326424010744	Protein of unknown function (DUF4232); Region: DUF4232; pfam14016
326424010745	Domain of unknown function DUF21; Region: DUF21; pfam01595
326424010746	Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253
326424010747	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
326424010748	Transporter associated domain; Region: CorC_HlyC; cl08393
326424010749	Domain of unknown function DUF21; Region: DUF21; pfam01595
326424010750	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
326424010751	FOG: CBS domain [General function prediction only]; Region: COG0517
326424010752	Methylase of polypeptide chain release factors [Translation, ribosomal structure and biogenesis]; Region: HemK; COG2890
326424010753	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
326424010754	S-adenosylmethionine binding site [chemical binding]; other site
326424010755	Molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: DnaK; COG0443
326424010756	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
326424010757	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
326424010758	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
326424010759	active site
326424010760	ATP binding site [chemical binding]; other site
326424010761	substrate binding site [chemical binding]; other site
326424010762	activation loop (A-loop); other site
326424010763	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567
326424010764	structural tetrad; other site
326424010765	Molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: DnaK; COG0443
326424010766	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
326424010767	membrane ATPase/protein kinase; Provisional; Region: PRK09435
326424010768	The function of this protein family is unkown. The protein sequences are similar to the ArgK protein in E. coli. ArgK protein is a membrane ATPase which is required for transporting arginine, ornithine and lysine into the cells by the arginine and...; Region: ArgK-like; cd03114
326424010769	Walker A; other site
326424010770	Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM) family, Alpha subunit-like subfamily; contains proteins similar to the alpha subunit of Propionbacterium shermanni MCM, as well as human and E. coli MCM. Members of this subfamily contain...; Region: MM_CoA_mutase_alpha_like; cd03679
326424010771	methylmalonyl-CoA mutase; Reviewed; Region: PRK09426
326424010772	active site
326424010773	substrate binding site [chemical binding]; other site
326424010774	coenzyme B12 binding site [chemical binding]; other site
326424010775	methylmalonyl CoA mutase B12 binding domain. This domain binds to B12 (adenosylcobamide), which initiates the conversion of succinyl CoA and methylmalonyl CoA by forming an adenosyl radical, which then undergoes a rearrangement exchanging a hydrogen atom...; Region: MM_CoA_mut_B12_BD; cd02071
326424010776	B12 binding site [chemical binding]; other site
326424010777	cobalt ligand [ion binding]; other site
326424010778	methylmalonyl-CoA mutase, heterodimeric type, beta chain; Region: mmCoA_mut_beta; TIGR00642
326424010779	Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM) family, Beta subunit-like subfamily; contains bacterial proteins similar to the beta subunit of MCMs from Propionbacterium shermanni and Streptomyces cinnamonensis, which are alpha/beta...; Region: MM_CoA_mutase_beta; cd03677
326424010780	heterodimer interface [polypeptide binding]; other site
326424010781	substrate interaction site [chemical binding]; other site
326424010782	Domain of unknown function (DUF4095); Region: DUF4095; pfam13338
326424010783	Secretory lipase; Region: LIP; pfam03583
326424010784	SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968
326424010785	Cu(I) binding site [ion binding]; other site
326424010786	Glycosyl hydrolases family 6; Region: Glyco_hydro_6; pfam01341
326424010787	Glycosyl hydrolases family 6; Region: Glyco_hydro_6; pfam01341
326424010788	Glyoxal oxidase N-terminus; Region: Glyoxal_oxid_N; pfam07250
326424010789	C-terminal Early set domain associated with the catalytic domain of galactose oxidase; Region: E_set_GO_C; cd02851
326424010790	CESA_CelA_like are involved in the elongation of the glucan chain of cellulose; Region: CESA_CelA_like; cd06421
326424010791	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
326424010792	DXD motif; other site
326424010793	cellulose synthase A (UDP-forming), catalytic subunit; Region: PLN02638
326424010794	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
326424010795	tellurite resistance protein terB; Region: terB; cd07176
326424010796	putative metal binding site [ion binding]; other site
326424010797	Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615
326424010798	active site
326424010799	catalytic site [active]
326424010800	adenylate kinase; Reviewed; Region: adk; PRK00279
326424010801	Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428
326424010802	AMP-binding site [chemical binding]; other site
326424010803	ATP-AMP (Ap5A)-binding site [chemical binding]; other site
326424010804	glutamate synthase subunit beta; Reviewed; Region: gltD; PRK12810
326424010805	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
326424010806	glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750
326424010807	Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713
326424010808	active site
326424010809	dimer interface [polypeptide binding]; other site
326424010810	Glutamate synthase central domain; Region: Glu_syn_central; pfam04898
326424010811	Glutamate synthase (GltS) FMN-binding domain.  GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808
326424010812	active site
326424010813	FMN binding site [chemical binding]; other site
326424010814	substrate binding site [chemical binding]; other site
326424010815	3Fe-4S cluster binding site [ion binding]; other site
326424010816	gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982
326424010817	domain interface; other site
326424010818	Prolipoprotein diacylglyceryl transferase; Region: LGT; cl00478
326424010819	tryptophan synthase subunit alpha; Provisional; Region: trpA; PRK13111
326424010820	Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724
326424010821	substrate binding site [chemical binding]; other site
326424010822	active site
326424010823	catalytic residues [active]
326424010824	heterodimer interface [polypeptide binding]; other site
326424010825	Tryptophan synthase-beta:  Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446
326424010826	Pyridoxal-phosphate dependent enzyme; Region: PALP; pfam00291
326424010827	pyridoxal 5'-phosphate binding site [chemical binding]; other site
326424010828	catalytic residue [active]
326424010829	Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331
326424010830	active site
326424010831	ribulose/triose binding site [chemical binding]; other site
326424010832	phosphate binding site [ion binding]; other site
326424010833	substrate (anthranilate) binding pocket [chemical binding]; other site
326424010834	product (indole) binding pocket [chemical binding]; other site
326424010835	Tryptophan-associated transmembrane protein (Trp_oprn_chp); Region: Trp_oprn_chp; pfam09534
326424010836	anthranilate synthase component I, non-proteobacterial lineages; Region: trpE_most; TIGR00564
326424010837	Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715
326424010838	chorismate binding enzyme; Region: Chorismate_bind; cl10555
326424010839	Phosphoribosyl-AMP cyclohydrolase; Region: PRA-CH; cl00344
326424010840	ABC transporter transmembrane region; Region: ABC_membrane; cl00549
326424010841	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
326424010842	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
326424010843	Walker A/P-loop; other site
326424010844	ATP binding site [chemical binding]; other site
326424010845	Q-loop/lid; other site
326424010846	ABC transporter signature motif; other site
326424010847	Walker B; other site
326424010848	D-loop; other site
326424010849	H-loop/switch region; other site
326424010850	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
326424010851	ABC transporter transmembrane region; Region: ABC_membrane; cl00549
326424010852	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
326424010853	Walker A/P-loop; other site
326424010854	ATP binding site [chemical binding]; other site
326424010855	Q-loop/lid; other site
326424010856	ABC transporter signature motif; other site
326424010857	Walker B; other site
326424010858	D-loop; other site
326424010859	H-loop/switch region; other site
326424010860	The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731
326424010861	Histidine biosynthesis protein; Region: His_biosynth; pfam00977
326424010862	substrate binding site [chemical binding]; other site
326424010863	glutamase interaction surface [polypeptide binding]; other site
326424010864	Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase [Amino acid transport and metabolism]; Region: HisA; COG0106
326424010865	HisA.  Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732
326424010866	catalytic residues [active]
326424010867	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
326424010868	Coenzyme A binding pocket [chemical binding]; other site
326424010869	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
326424010870	non-specific DNA binding site [nucleotide binding]; other site
326424010871	salt bridge; other site
326424010872	sequence-specific DNA binding site [nucleotide binding]; other site
326424010873	Domain of unknown function (DUF955); Region: DUF955; cl01076
326424010874	Plasmid maintenance system killer protein; Region: Plasmid_killer; cl01422
326424010875	Bacterial multiubiquitin; Region: Bac_multiUb; pfam14452
326424010876	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
326424010877	ATP binding site [chemical binding]; other site
326424010878	Type I restriction-modification system methyltransferase subunit [Defense mechanisms]; Region: HsdM; COG0286
326424010879	HsdM N-terminal domain; Region: HsdM_N; pfam12161
326424010880	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
326424010881	Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420
326424010882	EcoKI restriction-modification system protein HsdS; Provisional; Region: PRK09737
326424010883	Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: COG0610
326424010884	Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; cl14958
326424010885	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
326424010886	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
326424010887	Protein of unknown function DUF45; Region: DUF45; cl00636
326424010888	TIR domain; Region: TIR_2; cl15770
326424010889	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
326424010890	TPR motif; other site
326424010891	binding surface
326424010892	Tetratricopeptide repeat; Region: TPR_12; pfam13424
326424010893	Tetratricopeptide repeat; Region: TPR_12; pfam13424
326424010894	Tetratricopeptide repeat; Region: TPR_10; pfam13374
326424010895	imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13146
326424010896	Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748
326424010897	putative active site [active]
326424010898	oxyanion strand; other site
326424010899	catalytic triad [active]
326424010900	imidazoleglycerol-phosphate dehydratase; Validated; Region: hisB; PRK00951
326424010901	Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914
326424010902	putative active site pocket [active]
326424010903	4-fold oligomerization interface [polypeptide binding]; other site
326424010904	metal binding residues [ion binding]; metal-binding site
326424010905	3-fold/trimer interface [polypeptide binding]; other site
326424010906	histidinol-phosphate aminotransferase; Region: hisC; TIGR01141
326424010907	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
326424010908	histidinol dehydrogenase; Region: hisD; TIGR00069
326424010909	Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572
326424010910	NAD binding site [chemical binding]; other site
326424010911	dimerization interface [polypeptide binding]; other site
326424010912	product binding site; other site
326424010913	substrate binding site [chemical binding]; other site
326424010914	zinc binding site [ion binding]; other site
326424010915	catalytic residues [active]
326424010916	Protein of unknown function DUF43; Region: DUF43; pfam01861
326424010917	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
326424010918	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
326424010919	active site
326424010920	phosphorylation site [posttranslational modification]
326424010921	intermolecular recognition site; other site
326424010922	dimerization interface [polypeptide binding]; other site
326424010923	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
326424010924	DNA binding site [nucleotide binding]
326424010925	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
326424010926	dimerization interface [polypeptide binding]; other site
326424010927	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
326424010928	dimer interface [polypeptide binding]; other site
326424010929	phosphorylation site [posttranslational modification]
326424010930	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
326424010931	Mg2+ binding site [ion binding]; other site
326424010932	G-X-G motif; other site
326424010933	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075
326424010934	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
326424010935	O-methyltransferase; Region: Methyltransf_3; pfam01596
326424010936	Carboxymuconolactone decarboxylase family; Region: CMD; cl00460
326424010937	classical (c) SDRs; Region: SDR_c; cd05233
326424010938	NAD(P) binding site [chemical binding]; other site
326424010939	active site
326424010940	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
326424010941	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
326424010942	Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876
326424010943	Aminoglycoside-2''-adenylyltransferase; Region: Aminoglyc_resit; pfam10706
326424010944	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
326424010945	S-adenosylmethionine binding site [chemical binding]; other site
326424010946	bifunctional nitric oxide dioxygenase/dihydropteridine reductase 2; Provisional; Region: PRK13289
326424010947	Globins are heme proteins, which bind and transport oxygen. This family summarizes a diverse set of homologous protein domains, including: (1) tetrameric vertebrate hemoglobins, which are the major protein component of erythrocytes and transport oxygen...; Region: globin; cd01040
326424010948	heme-binding site [chemical binding]; other site
326424010949	FAD_NAD(P)H binding domain of flavohemoglobin. Flavohemoglobins have a globin domain containing a B-type heme fused with a ferredoxin reductase-like FAD/NAD-binding domain. Flavohemoglobins detoxify nitric oxide (NO) via an NO dioxygenase reaction. The...; Region: flavohem_like_fad_nad_binding; cd06184
326424010950	FAD binding pocket [chemical binding]; other site
326424010951	FAD binding motif [chemical binding]; other site
326424010952	phosphate binding motif [ion binding]; other site
326424010953	beta-alpha-beta structure motif; other site
326424010954	NAD binding pocket [chemical binding]; other site
326424010955	Heme binding  pocket [chemical binding]; other site
326424010956	TIR domain; Region: TIR_2; cl15770
326424010957	CCC1-related family of proteins; Region: CCC1_like; cl00278
326424010958	PEP phosphonomutase and related enzymes [Carbohydrate transport and metabolism]; Region: PrpB; COG2513
326424010959	Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377
326424010960	tetramer interface [polypeptide binding]; other site
326424010961	active site
326424010962	Mg2+/Mn2+ binding site [ion binding]; other site
326424010963	MmgE/PrpD family; Region: MmgE_PrpD; cl00912
326424010964	Peptidase inhibitor I9; Region: Inhibitor_I9; pfam05922
326424010965	Peptidase S8 family domain in ProteinaseK-like proteins; Region: Peptidases_S8_PCSK9_ProteinaseK_like; cd04077
326424010966	calcium binding site 2 [ion binding]; other site
326424010967	active site
326424010968	catalytic triad [active]
326424010969	calcium binding site 1 [ion binding]; other site
326424010970	Periplasmic binding protein; Region: Peripla_BP_6; pfam13458
326424010971	Type I periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type active transport systems that are predicted to be involved in transport of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_7; cd06341
326424010972	putative ligand binding site [chemical binding]; other site
326424010973	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
326424010974	TM-ABC transporter signature motif; other site
326424010975	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
326424010976	TM-ABC transporter signature motif; other site
326424010977	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410
326424010978	LivF (TM1139) is part of the LIV-I bacterial ABC-type two-component transport system that imports neutral, branched-chain amino acids.  The  E. coli branched-chain amino acid transporter comprises a heterodimer of ABC transporters (LivF and LivG), a...; Region: ABC_TM1139_LivF_branched; cd03224
326424010979	Walker A/P-loop; other site
326424010980	ATP binding site [chemical binding]; other site
326424010981	Q-loop/lid; other site
326424010982	ABC transporter signature motif; other site
326424010983	Walker B; other site
326424010984	D-loop; other site
326424010985	H-loop/switch region; other site
326424010986	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411
326424010987	The Mj1267/LivG ABC transporter subfamily is involved in the transport of the hydrophobic amino acids leucine, isoleucine and valine.  MJ1267 is a branched-chain amino acid transporter with 29% similarity to both the LivF and LivG components of the E; Region: ABC_Mj1267_LivG_branched; cd03219
326424010988	Walker A/P-loop; other site
326424010989	ATP binding site [chemical binding]; other site
326424010990	Q-loop/lid; other site
326424010991	ABC transporter signature motif; other site
326424010992	Walker B; other site
326424010993	D-loop; other site
326424010994	H-loop/switch region; other site
326424010995	putative hydrolase, CocE/NonD family; Region: /NonD; TIGR00976
326424010996	X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; cl08482
326424010997	Lamin Tail Domain; Region: LTD; pfam00932
326424010998	SdiA-regulated; Region: SdiA-regulated; cd09971
326424010999	putative active site [active]
326424011000	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
326424011001	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761
326424011002	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
326424011003	S-adenosylmethionine binding site [chemical binding]; other site
326424011004	Protein of unknown function (DUF3494); Region: DUF3494; pfam11999
326424011005	Peroxiredoxin (PRX) family, AhpE-like subfamily; composed of proteins similar to Mycobacterium tuberculosis AhpE. AhpE is described as a 1-cys PRX because of the absence of a resolving cysteine. The structure and sequence of AhpE, however, show greater...; Region: PRX_AhpE_like; cd03018
326424011006	dimer interface [polypeptide binding]; other site
326424011007	catalytic triad [active]
326424011008	Domain of unknown function (DUF4234); Region: DUF4234; pfam14018
326424011009	Protein of unknown function (DUF3052); Region: DUF3052; pfam11253
326424011010	Uncharacterized protein family UPF0047; Region: UPF0047; cl00439
326424011011	pyruvate dehydrogenase subunit E1; Reviewed; Region: aceE; PRK09405
326424011012	Thiamine pyrophosphate (TPP) family, E1 of E. coli PDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the Escherichia coli pyruvate dehydrogenase multienzyme complex (PDC). PDC catalyzes the oxidative...; Region: TPP_E1_EcPDC_like; cd02017
326424011013	dimer interface [polypeptide binding]; other site
326424011014	TPP-binding site [chemical binding]; other site
326424011015	Pyrimidine (PYR) binding domain of thiamine pyrophosphate (TPP)-dependent enzymes; Region: TPP_enzyme_PYR; cl11410
326424011016	Diacylglycerol kinase catalytic domain; Region: DAGK_cat; cl01255
326424011017	Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597
326424011018	dolichyl-phosphate beta-D-mannosyltransferase; Region: PLN02726
326424011019	DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179
326424011020	Ligand binding site; other site
326424011021	Putative Catalytic site; other site
326424011022	DXD motif; other site
326424011023	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
326424011024	Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637
326424011025	Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391
326424011026	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
326424011027	motif II; other site
326424011028	Plasmid stabilisation system protein; Region: Plasmid_stabil; cl11422
326424011029	Domain of unknown function (DUF1990); Region: DUF1990; cl01969
326424011030	Domain of unknown function (DUF1990); Region: DUF1990; cl01969
326424011031	Uncharacterized proteins involved in stress response, homologs of TerZ and putative cAMP-binding protein CABP1 [Signal transduction mechanisms]; Region: TerZ; COG2310
326424011032	Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974
326424011033	putative metal binding site [ion binding]; other site
326424011034	Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446
326424011035	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
326424011036	CoenzymeA binding site [chemical binding]; other site
326424011037	subunit interaction site [polypeptide binding]; other site
326424011038	PHB binding site; other site
326424011039	lycopene cyclase domain; Region: CarR_dom_SF; TIGR03462
326424011040	lycopene cyclase domain; Region: CarR_dom_SF; TIGR03462
326424011041	Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564
326424011042	active site
326424011043	thiamine phosphate binding site [chemical binding]; other site
326424011044	pyrophosphate binding site [ion binding]; other site
326424011045	ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565
326424011046	thiS-thiF/thiG interaction site; other site
326424011047	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
326424011048	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
326424011049	thiazole biosynthesis protein ThiH; Region: thiH; TIGR02351
326424011050	Biotin and Thiamin Synthesis associated domain; Region: BATS; cl06149
326424011051	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl09108
326424011052	phosphate binding site [ion binding]; other site
326424011053	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
326424011054	Catalytic domain of Protein Kinases; Region: PKc; cd00180
326424011055	active site
326424011056	ATP binding site [chemical binding]; other site
326424011057	substrate binding site [chemical binding]; other site
326424011058	activation loop (A-loop); other site
326424011059	PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577
326424011060	PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577
326424011061	PASTA domain. This domain is found at the C-termini of several Penicillin-binding proteins (PBPs) and bacterial serine/threonine kinases. It is a small globular fold consisting of 3 beta-sheets and an alpha-helix. The name PASTA is derived from PBP and...; Region: PASTA; cl02768
326424011062	Class-II DAHP synthetase family; Region: DAHP_synth_2; cl03230
326424011063	Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to PFK family that includes ATP- and pyrophosphate (PPi)- dependent phosphofructokinases; Region: PFK; cd00363
326424011064	active site
326424011065	ADP/pyrophosphate binding site [chemical binding]; other site
326424011066	dimerization interface [polypeptide binding]; other site
326424011067	allosteric effector site; other site
326424011068	fructose-1,6-bisphosphate binding site; other site
326424011069	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
326424011070	putative acyl-acceptor binding pocket; other site
326424011071	Esterase/lipase [General function prediction only]; Region: COG1647
326424011072	LOR/SDH bifunctional enzyme conserved region; Region: Saccharop_dh_N; pfam04455
326424011073	TIGR00300 family protein; Region: TIGR00300
326424011074	FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121
326424011075	Anion-transporting ATPase; Region: ArsA_ATPase; pfam02374
326424011076	ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035
326424011077	DTAP/Switch II; other site
326424011078	Switch I; other site
326424011079	Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_2; cd07819
326424011080	putative hydrophobic ligand binding site [chemical binding]; other site
326424011081	Predicted phosphoesterases, related to the Icc protein [General function prediction only]; Region: COG2129
326424011082	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cd00838
326424011083	Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022
326424011084	AMP-binding enzyme; Region: AMP-binding; cl15778
326424011085	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
326424011086	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
326424011087	YacP-like NYN domain; Region: NYN_YacP; cl01491
326424011088	Domain of unknown function (DUF4352); Region: DUF4352; pfam11611
326424011089	HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the basis...; Region: HIT_like; cl00228
326424011090	nucleotide binding site/active site [active]
326424011091	HIT family signature motif; other site
326424011092	catalytic residue [active]
326424011093	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632
326424011094	hypothetical protein; Validated; Region: PRK07883
326424011095	DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127
326424011096	active site
326424011097	substrate binding site [chemical binding]; other site
326424011098	catalytic site [active]
326424011099	Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434
326424011100	GIY-YIG motif/motif A; other site
326424011101	active site
326424011102	catalytic site [active]
326424011103	putative DNA binding site [nucleotide binding]; other site
326424011104	metal binding site [ion binding]; metal-binding site
326424011105	Cytochrome b subunit of the bc complex [Energy production and conversion]; Region: QcrB; COG1290
326424011106	Cytochrome b (N-terminus)/b6/petB:  Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859
326424011107	heme bH binding site [chemical binding]; other site
326424011108	Qi binding site; other site
326424011109	intrachain domain interface; other site
326424011110	heme bL binding site [chemical binding]; other site
326424011111	interchain domain interface [polypeptide binding]; other site
326424011112	Qo binding site; other site
326424011113	Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467
326424011114	iron-sulfur cluster [ion binding]; other site
326424011115	[2Fe-2S] cluster binding site [ion binding]; other site
326424011116	Cytochrome c; Region: Cytochrom_C; cl11414
326424011117	Cytochrome c; Region: Cytochrom_C; cl11414
326424011118	Heme-copper oxidase subunit III.  Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which couple the reduction of molecular oxygen to water to, proton pumping across the membrane. The...; Region: Heme_Cu_Oxidase_III_like; cd00386
326424011119	Subunit I/III interface [polypeptide binding]; other site
326424011120	Protein of unknown function (DUF3501); Region: DUF3501; pfam12007
326424011121	Rubrerythrin, ferritin-like diiron-binding domain; Region: Rubrerythrin; cd01041
326424011122	binuclear metal center [ion binding]; other site
326424011123	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153
326424011124	metal binding site 2 [ion binding]; metal-binding site
326424011125	putative DNA binding helix; other site
326424011126	metal binding site 1 [ion binding]; metal-binding site
326424011127	dimer interface [polypeptide binding]; other site
326424011128	structural Zn2+ binding site [ion binding]; other site
326424011129	Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885
326424011130	Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591
326424011131	Cytochrome c oxidase subunit IV; Region: Cyt_c_ox_IV; pfam12270
326424011132	Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843
326424011133	Ubiquinol oxidase subunit I.  Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane.  It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662
326424011134	D-pathway; other site
326424011135	Putative ubiquinol binding site [chemical binding]; other site
326424011136	Low-spin heme (heme b) binding site [chemical binding]; other site
326424011137	Putative water exit pathway; other site
326424011138	Binuclear center (heme o3/CuB) [ion binding]; other site
326424011139	K-pathway; other site
326424011140	Putative proton exit pathway; other site
326424011141	cytochrome c oxidase, subunit II; Region: CoxB; TIGR02866
326424011142	Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; cl11412
326424011143	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
326424011144	cysteine desulfurase DndA; Region: DNA_S_dndA; TIGR03235
326424011145	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
326424011146	catalytic residue [active]
326424011147	SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain.  SirA (also known as UvrY,  and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291
326424011148	CPxP  motif; other site
326424011149	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
326424011150	Ribokinase-like subgroup A.  Found in bacteria and archaea, this subgroup is part of the ribokinase/pfkB superfamily.  Its oligomerization state is unknown at this time; Region: ribokinase_group_A; cd01942
326424011151	substrate binding site [chemical binding]; other site
326424011152	ATP binding site [chemical binding]; other site
326424011153	Iron-sulphur cluster biosynthesis; Region: Fe-S_biosyn; cl00400
326424011154	Quinolinate synthetase A protein; Region: NadA; cl00420
326424011155	Protein of unknown function (DUF3043); Region: DUF3043; pfam11241
326424011156	Predicted oxidoreductases (related to aryl-alcohol dehydrogenases) [Energy production and conversion]; Region: Tas; COG0667
326424011157	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
326424011158	active site
326424011159	catalytic tetrad [active]
326424011160	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
326424011161	substrate binding site [chemical binding]; other site
326424011162	oxyanion hole (OAH) forming residues; other site
326424011163	trimer interface [polypeptide binding]; other site
326424011164	Helix-turn-helix domains; Region: HTH; cl00088
326424011165	Domain of unknown function (DUF385); Region: DUF385; cl04387
326424011166	Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446
326424011167	Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446
326424011168	Adenosylcobinamide kinase / adenosylcobinamide phosphate guanyltransferase (CobU). CobU is bifunctional cobalbumin biosynthesis enzymes which display adenosylcobinamide kinase and adenosylcobinamide phosphate guanyltransferase activity. This enzyme is a...; Region: CobU; cd00544
326424011169	homotrimer interface [polypeptide binding]; other site
326424011170	Walker A motif; other site
326424011171	GTP binding site [chemical binding]; other site
326424011172	Walker B motif; other site
326424011173	Domain of unknown function (DUF4062); Region: DUF4062; pfam13271
326424011174	NB-ARC domain; Region: NB-ARC; pfam00931
326424011175	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200
326424011176	structural tetrad; other site
326424011177	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200
326424011178	structural tetrad; other site
326424011179	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200
326424011180	structural tetrad; other site
326424011181	Phosphoribosyltransferase; Region: DBI_PRT; pfam02277
326424011182	Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (DMB-PRT), also called CobT; Region: DMB-PRT_CobT; cd02439
326424011183	putative dimer interface [polypeptide binding]; other site
326424011184	active site pocket [active]
326424011185	putative cataytic base [active]
326424011186	Cobalamin-5-phosphate synthase; Region: CobS; cl00415
326424011187	putative Zn-ribbon RNA-binding protein; Provisional; Region: PRK14890
326424011188	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057
326424011189	metal ion-dependent adhesion site (MIDAS); other site
326424011190	Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cl00120
326424011191	glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389
326424011192	Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669
326424011193	Leucyl aminopeptidase [Amino acid transport and metabolism]; Region: PepB; COG0260
326424011194	Cytosol aminopeptidase family, N-terminal and catalytic domains.  Family M17 contains zinc- and manganese-dependent exopeptidases ( EC  3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433
326424011195	interface (dimer of trimers) [polypeptide binding]; other site
326424011196	Substrate-binding/catalytic site; other site
326424011197	Zn-binding sites [ion binding]; other site
326424011198	dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06416
326424011199	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
326424011200	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
326424011201	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
326424011202	E3 interaction surface; other site
326424011203	lipoyl attachment site [posttranslational modification]; other site
326424011204	dihydrolipoamide acetyltransferase; Reviewed; Region: PRK11857
326424011205	e3 binding domain; Region: E3_binding; pfam02817
326424011206	2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; cl02008
326424011207	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
326424011208	TIGR01777 family protein; Region: yfcH
326424011209	NAD(P) binding site [chemical binding]; other site
326424011210	active site
326424011211	Type 1 glutamine amidotransferase (GATase1)-like domain found in peptidase E; Region: GAT1_Peptidase_E; cd03146
326424011212	active site pocket [active]
326424011213	oxyanion hole [active]
326424011214	catalytic triad [active]
326424011215	active site nucleophile [active]
326424011216	Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057
326424011217	lipoyl synthase; Provisional; Region: PRK05481
326424011218	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
326424011219	FeS/SAM binding site; other site
326424011220	Domain of unknown function (DUF4191); Region: DUF4191; pfam13829
326424011221	RDD family; Region: RDD; cl00746
326424011222	glutamine synthetase, type I; Region: GlnA; TIGR00653
326424011223	Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951
326424011224	Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120
326424011225	glutamine synthetase; Region: PLN02284
326424011226	Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951
326424011227	Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120
326424011228	bifunctional glutamine-synthetase adenylyltransferase/deadenyltransferase; Provisional; Region: PRK14109
326424011229	Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401
326424011230	metal binding triad; other site
326424011231	GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335
326424011232	Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401
326424011233	metal binding triad; other site
326424011234	Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174
326424011235	Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951
326424011236	Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120
326424011237	Pyruvate ferredoxin/flavodoxin oxidoreductase; Region: POR; cl00546
326424011238	The TGS domain, named after the ThrRS, GTPase, and SpoT/RelA proteins where it occurs, is structurally similar to ubiquitin. TGS is a small domain of about 50 amino acid residues with a predominantly beta-sheet structure. There is no direct information...; Region: TGS; cl15768
326424011239	threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK12305
326424011240	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; cl08469
326424011241	Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771
326424011242	active site
326424011243	dimer interface [polypeptide binding]; other site
326424011244	motif 1; other site
326424011245	motif 2; other site
326424011246	motif 3; other site
326424011247	ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860
326424011248	anticodon binding site; other site
326424011249	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
326424011250	Helix-turn-helix domains; Region: HTH; cl00088
326424011251	Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557
326424011252	active site
326424011253	oligomerization interface [polypeptide binding]; other site
326424011254	metal binding site [ion binding]; metal-binding site
326424011255	Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+.  Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262
326424011256	intersubunit interface [polypeptide binding]; other site
326424011257	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
326424011258	site-specific tyrosine recombinase XerD; Reviewed; Region: xerD; PRK00283
326424011259	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
326424011260	DNA binding site [nucleotide binding]
326424011261	Int/Topo IB signature motif; other site
326424011262	active site
326424011263	Early set domain associated with the catalytic domain of sugar utilizing enzymes at either the N or C terminus; Region: E_set; cl09101
326424011264	ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424
326424011265	dimer interface [polypeptide binding]; other site
326424011266	active site
326424011267	ADP-ribose binding site [chemical binding]; other site
326424011268	nudix motif; other site
326424011269	metal binding site [ion binding]; metal-binding site
326424011270	CTP synthetase; Validated; Region: pyrG; PRK05380
326424011271	CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113
326424011272	Catalytic site [active]
326424011273	active site
326424011274	UTP binding site [chemical binding]; other site
326424011275	Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746
326424011276	active site
326424011277	putative oxyanion hole; other site
326424011278	catalytic triad [active]
326424011279	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
326424011280	Predicted oxidoreductases (related to aryl-alcohol dehydrogenases) [Energy production and conversion]; Region: Tas; COG0667
326424011281	active site
326424011282	catalytic tetrad [active]
326424011283	ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497
326424011284	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
326424011285	Walker A/P-loop; other site
326424011286	ATP binding site [chemical binding]; other site
326424011287	Q-loop/lid; other site
326424011288	RecN ATPase involved in DNA repair; ABC (ATP-binding cassette) transporter nucleotide-binding domain; ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds including sugars, ions, peptides, and...; Region: ABC_RecN; cd03241
326424011289	ABC transporter signature motif; other site
326424011290	Walker B; other site
326424011291	D-loop; other site
326424011292	H-loop/switch region; other site
326424011293	Diacylglycerol kinase catalytic domain; Region: DAGK_cat; cl01255
326424011294	Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189
326424011295	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl15754
326424011296	SCP-2 sterol transfer family; Region: SCP2; cl01225
326424011297	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
326424011298	hypothetical protein; Provisional; Region: PRK06847
326424011299	Predicted sugar phosphatases of the HAD superfamily [Carbohydrate transport and metabolism]; Region: NagD; COG0647
326424011300	Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391
326424011301	Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391
326424011302	Tetratricopeptide repeat; Region: TPR_16; pfam13432
326424011303	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
326424011304	TPR motif; other site
326424011305	Protein of unknown function (DUF1015); Region: DUF1015; cl01715
326424011306	Protein of unknown function (DUF1015); Region: DUF1015; cl01715
326424011307	Alkyladenine DNA glycosylase catalyzes the first step in base excision repair; Region: AAG; cd00540
326424011308	active site
326424011309	DNA binding site [nucleotide binding]
326424011310	Carboxy-terminal domain of Formyltransferase and similar domains; Region: FMT_C_like; cl14785
326424011311	argininosuccinate lyase; Provisional; Region: PRK00855
326424011312	Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359
326424011313	active sites [active]
326424011314	tetramer interface [polypeptide binding]; other site
326424011315	Argininosuccinate synthase [Amino acid transport and metabolism]; Region: ArgG; COG0137
326424011316	Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate .  In...; Region: Argininosuccinate_Synthase; cd01999
326424011317	ANP binding site [chemical binding]; other site
326424011318	Substrate Binding Site II [chemical binding]; other site
326424011319	Substrate Binding Site I [chemical binding]; other site
326424011320	Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316
326424011321	Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863
326424011322	ornithine carbamoyltransferase; Provisional; Region: PRK00779
326424011323	Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729
326424011324	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
326424011325	acetylornithine aminotransferase; Provisional; Region: argD; PRK03244
326424011326	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
326424011327	inhibitor-cofactor binding pocket; inhibition site
326424011328	pyridoxal 5'-phosphate binding site [chemical binding]; other site
326424011329	catalytic residue [active]
326424011330	AAK_NAGK-C: N-Acetyl-L-glutamate kinase - cyclic (NAGK-C) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine biosynthesis found in some bacteria and photosynthetic organisms using the...; Region: AAK_NAGK-C; cd04250
326424011331	feedback inhibition sensing region; other site
326424011332	homohexameric interface [polypeptide binding]; other site
326424011333	nucleotide binding site [chemical binding]; other site
326424011334	N-acetyl-L-glutamate binding site [chemical binding]; other site
326424011335	Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152
326424011336	heterotetramer interface [polypeptide binding]; other site
326424011337	active site pocket [active]
326424011338	cleavage site
326424011339	N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436
326424011340	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
326424011341	Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; cl15856
326424011342	phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629
326424011343	tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain.  PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796
326424011344	putative tRNA-binding site [nucleotide binding]; other site
326424011345	B3/4 domain; Region: B3_4; cl11458
326424011346	tRNA synthetase B5 domain; Region: B5; cl08394
326424011347	Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA,  PheRS is an...; Region: PheRS_beta_core; cd00769
326424011348	dimer interface [polypeptide binding]; other site
326424011349	motif 1; other site
326424011350	motif 3; other site
326424011351	motif 2; other site
326424011352	Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; cl08386
326424011353	Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912
326424011354	phenylalanyl-tRNA synthetase, alpha subunit; Region: pheS; TIGR00468
326424011355	Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496
326424011356	dimer interface [polypeptide binding]; other site
326424011357	motif 1; other site
326424011358	active site
326424011359	motif 2; other site
326424011360	motif 3; other site
326424011361	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: VicK; COG5002
326424011362	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
326424011363	dimer interface [polypeptide binding]; other site
326424011364	phosphorylation site [posttranslational modification]
326424011365	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
326424011366	ATP binding site [chemical binding]; other site
326424011367	Mg2+ binding site [ion binding]; other site
326424011368	G-X-G motif; other site
326424011369	RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; cl06870
326424011370	SpoU rRNA Methylase family; Region: SpoU_methylase; cl00362
326424011371	ribosomal protein L20; Region: rpl20; CHL00068
326424011372	Ribosomal protein L20; Region: Ribosomal_L20; cd07026
326424011373	23S rRNA binding site [nucleotide binding]; other site
326424011374	L21 binding site [polypeptide binding]; other site
326424011375	L13 binding site [polypeptide binding]; other site
326424011376	Ribosomal protein L35; Region: Ribosomal_L35p; cl00392
326424011377	Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198
326424011378	Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707
326424011379	Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455
326424011380	lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209
326424011381	homopentamer interface [polypeptide binding]; other site
326424011382	active site
326424011383	bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09311
326424011384	3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; cl00336
326424011385	GTP cyclohydrolase II (RibA).  GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641
326424011386	dimerization interface [polypeptide binding]; other site
326424011387	active site
326424011388	riboflavin synthase subunit alpha; Provisional; Region: PRK09289
326424011389	Lumazine binding domain; Region: Lum_binding; pfam00677
326424011390	Lumazine binding domain; Region: Lum_binding; pfam00677
326424011391	Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284
326424011392	catalytic motif [active]
326424011393	Zn binding site [ion binding]; other site
326424011394	Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429
326424011395	ribulose-phosphate 3-epimerase; Region: rpe; TIGR01163
326424011396	substrate binding site [chemical binding]; other site
326424011397	hexamer interface [polypeptide binding]; other site
326424011398	metal binding site [ion binding]; metal-binding site
326424011399	16S rRNA methyltransferase B; Provisional; Region: PRK14901
326424011400	RNA binding domain of NusB (N protein-Utilization Substance B) and Sun (also known as RrmB or Fmu) proteins. This family includes two orthologous groups exemplified by the transcription termination factor NusB and the N-terminal domain of the...; Region: NusB_Sun; cl00223
326424011401	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl15754
326424011402	methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005
326424011403	Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646
326424011404	putative active site [active]
326424011405	substrate binding site [chemical binding]; other site
326424011406	putative cosubstrate binding site; other site
326424011407	catalytic site [active]
326424011408	C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704
326424011409	substrate binding site [chemical binding]; other site
326424011410	primosome assembly protein PriA; Provisional; Region: PRK14873
326424011411	S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438
326424011412	S-adenosylmethionine synthetase; Validated; Region: PRK05250
326424011413	S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772
326424011414	S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773
326424011415	bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579
326424011416	Flavoprotein; Region: Flavoprotein; cl08021
326424011417	DNA / pantothenate metabolism flavoprotein; Region: DFP; cl04410
326424011418	RNA polymerase Rpb6; Region: RNA_pol_Rpb6; cl14651
326424011419	Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071
326424011420	catalytic site [active]
326424011421	G-X2-G-X-G-K; other site
326424011422	Ribosomal protein S13/S18; Region: Ribosomal_S13; cl00331
326424011423	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl09108
326424011424	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl09108
326424011425	phosphate binding site [ion binding]; other site
326424011426	carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294
326424011427	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
326424011428	ATP-grasp domain; Region: ATP-grasp_4; cl03087
326424011429	Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787
326424011430	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
326424011431	ATP-grasp domain; Region: ATP-grasp_4; cl03087
326424011432	Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424
326424011433	IMP binding site; other site
326424011434	dimer interface [polypeptide binding]; other site
326424011435	interdomain contacts; other site
326424011436	partial ornithine binding site; other site
326424011437	carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564
326424011438	Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; cl03056
326424011439	Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744
326424011440	catalytic site [active]
326424011441	subunit interface [polypeptide binding]; other site
326424011442	dihydroorotase; Validated; Region: pyrC; PRK09357
326424011443	Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317
326424011444	active site
326424011445	aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856
326424011446	Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729
326424011447	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
326424011448	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
326424011449	active site
326424011450	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
326424011451	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
326424011452	non-specific DNA binding site [nucleotide binding]; other site
326424011453	salt bridge; other site
326424011454	sequence-specific DNA binding site [nucleotide binding]; other site
326424011455	Transcription termination factor NusB (N protein-Utilization Substance B). NusB plays a key role in the regulation of ribosomal RNA biosynthesis in eubacteria by modulating the efficiency of transcriptional antitermination. NusB along with other Nus...; Region: Terminator_NusB; cd00619
326424011456	elongation factor P; Validated; Region: PRK00529
326424011457	Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207
326424011458	S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470
326424011459	RNA binding site [nucleotide binding]; other site
326424011460	S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794
326424011461	RNA binding site [nucleotide binding]; other site
326424011462	Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195
326424011463	dimer interface [polypeptide binding]; other site
326424011464	active site
326424011465	metal binding site [ion binding]; metal-binding site
326424011466	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
326424011467	active site
326424011468	Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304
326424011469	Tetramer interface [polypeptide binding]; other site
326424011470	active site
326424011471	FMN-binding site [chemical binding]; other site
326424011472	shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258
326424011473	Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501
326424011474	NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065
326424011475	NAD(P) binding site [chemical binding]; other site
326424011476	shikimate binding site; other site
326424011477	YceG-like family; Region: YceG; pfam02618
326424011478	proteins similar to Escherichia coli yceG; Region: yceG_like; cl00675
326424011479	Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination.  HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD includes...; Region: RuvC_resolvase; cl00243
326424011480	alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252
326424011481	Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent formation of...; Region: AlaRS_core; cd00673
326424011482	motif 1; other site
326424011483	active site
326424011484	motif 2; other site
326424011485	motif 3; other site
326424011486	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; cl08469
326424011487	DHHA1 domain; Region: DHHA1; pfam02272
326424011488	Bacterial protein of unknown function (DUF948); Region: DUF948; cl01972
326424011489	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
326424011490	Walker A motif; other site
326424011491	ATP binding site [chemical binding]; other site
326424011492	Walker B motif; other site
326424011493	MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002
326424011494	MHYT domain (predicted integral membrane sensor domain) [Signal transduction mechanisms]; Region: COG3300
326424011495	Bacterial signalling protein N terminal repeat; Region: MHYT; pfam03707
326424011496	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
326424011497	DNA-binding site [nucleotide binding]; DNA binding site
326424011498	glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406
326424011499	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
326424011500	active site
326424011501	HIGH motif; other site
326424011502	nucleotide binding site [chemical binding]; other site
326424011503	catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808
326424011504	active site
326424011505	KMSKS motif; other site
326424011506	Helix-turn-helix domains; Region: HTH; cl00088
326424011507	Pectinesterase; Region: Pectinesterase; cl01911
326424011508	Right handed beta helix region; Region: Beta_helix; pfam13229
326424011509	Right handed beta helix region; Region: Beta_helix; pfam13229
326424011510	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
326424011511	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
326424011512	Walker A motif; other site
326424011513	ATP binding site [chemical binding]; other site
326424011514	Walker B motif; other site
326424011515	arginine finger; other site
326424011516	Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+.  Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262
326424011517	Periplasmic binding protein; Region: Peripla_BP_2; pfam01497
326424011518	intersubunit interface [polypeptide binding]; other site
326424011519	Dienelactone hydrolase family; Region: DLH; pfam01738
326424011520	Acyl-CoA dehydrogenase (ACAD) 10 and 11, N-terminal domain, and similar proteins. This subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: ACAD10_11_like; cd05154
326424011521	putative active site [active]
326424011522	putative substrate binding site [chemical binding]; other site
326424011523	ATP binding site [chemical binding]; other site
326424011524	long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187
326424011525	AMP-binding enzyme; Region: AMP-binding; cl15778
326424011526	Mycobacterium tuberculosis aldehyde dehydrogenase AldA-like; Region: ALDH_AldA-Rv0768; cd07139
326424011527	gamma-glutamyl-gamma-aminobutyraldehyde dehydrogenase; Provisional; Region: PRK09847
326424011528	NAD binding site [chemical binding]; other site
326424011529	catalytic residues [active]
326424011530	oxidoreductase, Rxyl_3153 family; Region: Rxyl_3153; TIGR03989
326424011531	Class III alcohol dehydrogenase; Region: Zn_ADH_class_III; cd08279
326424011532	NAD binding site [chemical binding]; other site
326424011533	catalytic Zn binding site [ion binding]; other site
326424011534	substrate binding site [chemical binding]; other site
326424011535	structural Zn binding site [ion binding]; other site
326424011536	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; cl12078
326424011537	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
326424011538	substrate binding site [chemical binding]; other site
326424011539	oxyanion hole (OAH) forming residues; other site
326424011540	trimer interface [polypeptide binding]; other site
326424011541	AMP-binding enzyme; Region: AMP-binding; cl15778
326424011542	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
326424011543	Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695
326424011544	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
326424011545	Acyl-CoA synthetase (NDP forming) [Energy production and conversion]; Region: COG1042
326424011546	CoA-ligase; Region: Ligase_CoA; cl02894
326424011547	ATP-grasp domain; Region: ATP-grasp_4; cl03087
326424011548	probable AcnD-accessory protein PrpF; Region: prpF; TIGR02334
326424011549	PrpF protein; Region: PrpF; pfam04303
326424011550	NIPSNAP; Region: NIPSNAP; pfam07978
326424011551	N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346
326424011552	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
326424011553	Zn binding site [ion binding]; other site
326424011554	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
326424011555	DNA binding site [nucleotide binding]
326424011556	GAF domain; Region: GAF_2; pfam13185
326424011557	GAF domain; Region: GAF; cl15785
326424011558	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
326424011559	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
326424011560	GlcNAc-PI de-N-acetylase; Region: PIG-L; cl00929
326424011561	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
326424011562	PAS domain; Region: PAS_9; pfam13426
326424011563	putative active site [active]
326424011564	heme pocket [chemical binding]; other site
326424011565	PAS domain S-box; Region: sensory_box; TIGR00229
326424011566	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
326424011567	metal binding site [ion binding]; metal-binding site
326424011568	active site
326424011569	I-site; other site
326424011570	Coproporphyrinogen III oxidase and related Fe-S oxidoreductases [Coenzyme metabolism]; Region: HemN; COG0635
326424011571	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
326424011572	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
326424011573	active site
326424011574	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
326424011575	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
326424011576	active site
326424011577	phosphorylation site [posttranslational modification]
326424011578	intermolecular recognition site; other site
326424011579	dimerization interface [polypeptide binding]; other site
326424011580	3-ketoacyl-(acyl-carrier-protein) reductase; Reviewed; Region: PRK12826
326424011581	classical (c) SDRs; Region: SDR_c; cd05233
326424011582	NAD(P) binding site [chemical binding]; other site
326424011583	active site
326424011584	ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120
326424011585	ABC transporters, involved in the uptake of siderophores, heme, and vitamin B12, are widely conserved in bacteria and archaea.  Only very few species lack representatives of the siderophore family transporters. The E. coli BtuCD protein is an ABC...; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214
326424011586	Walker A/P-loop; other site
326424011587	ATP binding site [chemical binding]; other site
326424011588	Q-loop/lid; other site
326424011589	ABC transporter signature motif; other site
326424011590	Walker B; other site
326424011591	D-loop; other site
326424011592	H-loop/switch region; other site
326424011593	TRAP-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: Imp; COG2358
326424011594	NMT1-like family; Region: NMT1_2; cl15260
326424011595	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
326424011596	Catalytic domain of Protein Kinases; Region: PKc; cd00180
326424011597	active site
326424011598	ATP binding site [chemical binding]; other site
326424011599	substrate binding site [chemical binding]; other site
326424011600	activation loop (A-loop); other site
326424011601	Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161
326424011602	Ricin-type beta-trefoil lectin domain; Region: Ricin_B_lectin; pfam00652
326424011603	putative sugar binding sites [chemical binding]; other site
326424011604	Q-X-W motif; other site
326424011605	DNA-binding transcriptional activator KdpE; Provisional; Region: PRK10529
326424011606	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
326424011607	active site
326424011608	phosphorylation site [posttranslational modification]
326424011609	intermolecular recognition site; other site
326424011610	dimerization interface [polypeptide binding]; other site
326424011611	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
326424011612	DNA binding site [nucleotide binding]
326424011613	K+-transporting ATPase, c chain; Region: KdpC; cl00944
326424011614	K+-transporting ATPase, c chain; Region: KdpC; cl00944
326424011615	potassium-transporting ATPase subunit B; Provisional; Region: PRK01122
326424011616	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
326424011617	Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391
326424011618	Potassium-transporting ATPase A subunit; Region: KdpA; cl00903
326424011619	Potassium-transporting ATPase A subunit; Region: KdpA; cl00903
326424011620	similar to hypothetical protein; Evidence 6 : Doubtful CDS
326424011621	Osmosensitive K+ channel histidine kinase [Signal transduction mechanisms]; Region: KdpD; COG2205
326424011622	Osmosensitive K+ channel His kinase sensor domain; Region: KdpD; pfam02702
326424011623	USP domain is located between the N-terminal sensor domain and C-terminal catalytic domain of this Osmosensitive K+ channel histidine kinase family. The family of KdpD sensor kinase proteins regulates the kdpFABC operon responsible for potassium...; Region: USP_OKCHK; cd01987
326424011624	Ligand Binding Site [chemical binding]; other site
326424011625	Domain of unknown function (DUF4118); Region: DUF4118; pfam13493
326424011626	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
326424011627	dimer interface [polypeptide binding]; other site
326424011628	phosphorylation site [posttranslational modification]
326424011629	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
326424011630	ATP binding site [chemical binding]; other site
326424011631	Mg2+ binding site [ion binding]; other site
326424011632	G-X-G motif; other site
326424011633	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
326424011634	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
326424011635	NAD(P) binding site [chemical binding]; other site
326424011636	active site
326424011637	Zinc dependent phospholipase C; Region: Zn_dep_PLPC; cl03005
326424011638	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
326424011639	Helix-turn-helix domains; Region: HTH; cl00088
326424011640	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
326424011641	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
326424011642	TIR domain; Region: TIR_2; cl15770
326424011643	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
326424011644	AAA domain; Region: AAA_22; pfam13401
326424011645	Walker A motif; other site
326424011646	ATP binding site [chemical binding]; other site
326424011647	Walker B motif; other site
326424011648	TIR domain; Region: TIR_2; cl15770
326424011649	Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer,  utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514
326424011650	FMN binding site [chemical binding]; other site
326424011651	dimer interface [polypeptide binding]; other site
326424011652	Helix-turn-helix domains; Region: HTH; cl00088
326424011653	H+ Antiporter protein; Region: 2A0121; TIGR00900
326424011654	RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
326424011655	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
326424011656	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761
326424011657	Uncharacterized conserved protein (DUF2156); Region: DUF2156; cl12090
326424011658	S-adenosyl methyltransferase; Region: Methyltransf_19; pfam04672
326424011659	Protein of unknown function (DUF2993); Region: DUF2993; pfam11209
326424011660	Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP; cl11399
326424011661	alkanesulfonate monooxygenase; Provisional; Region: PRK00719
326424011662	A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cd01066
326424011663	active site
326424011664	formate dehydrogenase, alpha subunit, archaeal-type; Region: Fdh-alpha; TIGR01591
326424011665	Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_Nitrate-R-NapA-like; cd02754
326424011666	molybdopterin cofactor binding site; other site
326424011667	Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_CT_Nitrate-R-NapA-like; cd02791
326424011668	molybdopterin cofactor binding site; other site
326424011669	sulfite reductase [NADPH] flavoprotein, alpha-component; Region: cysJ; TIGR01931
326424011670	NADPH-dependent FMN reductase; Region: FMN_red; cl00438
326424011671	Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron transport...; Region: FNR_like; cl06868
326424011672	FAD binding pocket [chemical binding]; other site
326424011673	conserved FAD binding motif [chemical binding]; other site
326424011674	phosphate binding motif [ion binding]; other site
326424011675	beta-alpha-beta structure motif; other site
326424011676	NAD binding pocket [chemical binding]; other site
326424011677	Predicted integral membrane proteins containing uncharacterized repeats [Function unknown]; Region: COG5563
326424011678	probable extracellular repeat, HAF family; Region: HAF_rpt; TIGR02913
326424011679	probable extracellular repeat, HAF family; Region: HAF_rpt; TIGR02913
326424011680	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
326424011681	putative substrate translocation pore; other site
326424011682	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
326424011683	putative substrate translocation pore; other site
326424011684	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
326424011685	Helix-turn-helix domains; Region: HTH; cl00088
326424011686	Acyl-CoA dehydrogenase (ACAD) 10 and 11, N-terminal domain, and similar proteins. This subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: ACAD10_11_like; cd05154
326424011687	putative active site [active]
326424011688	ATP binding site [chemical binding]; other site
326424011689	Protein of unknown function (DUF2867); Region: DUF2867; pfam11066
326424011690	Uncharacterized conserved protein (COG2071); Region: DUF2071; cl01329
326424011691	MT0933-like antitoxin protein; Region: MT0933_antitox; pfam14013
326424011692	PAS fold; Region: PAS_2; pfam08446
326424011693	GAF domain; Region: GAF; cl15785
326424011694	Phytochrome region; Region: PHY; pfam00360
326424011695	Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cl00120
326424011696	Heme oxygenase catalyzes the rate limiting step in the degradation of heme to bilirubin, it is essential for recycling of iron from heme. Heme is used as a substrate and cofactor for its own degradation to biliverdin, iron, and carbon monoxide. This...; Region: HemeO; cl15243
326424011697	heme binding pocket [chemical binding]; other site
326424011698	heme ligand [chemical binding]; other site
326424011699	A type 1 glutamine amidotransferase (GATase1)-like domain found in PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_like; cd03134
326424011700	intracellular protease, PfpI family; Region: PfpI; TIGR01382
326424011701	proposed catalytic triad [active]
326424011702	conserved cys residue [active]
326424011703	Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469
326424011704	[2Fe-2S] cluster binding site [ion binding]; other site
326424011705	C-terminal catalytic domain of the oxygenase alpha subunit of an uncharacterized subgroup of Rieske-type non-heme iron aromatic ring-hydroxylating oxygenases; Region: RHO_alpha_C_3; cd08887
326424011706	putative alpha subunit interface [polypeptide binding]; other site
326424011707	putative active site [active]
326424011708	putative substrate binding site [chemical binding]; other site
326424011709	Fe binding site [ion binding]; other site
326424011710	non-haem dioxygenase in morphine synthesis N-terminal; Region: DIOX_N; cl14733
326424011711	2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy; cl15773
326424011712	Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG3618
326424011713	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
326424011714	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
326424011715	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557
326424011716	NAD(P) binding site [chemical binding]; other site
326424011717	active site
326424011718	Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210
326424011719	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
326424011720	Family description; Region: UvrD_C_2; cl15862
326424011721	Enterochelin esterase and related enzymes [Inorganic ion transport and metabolism]; Region: Fes; COG2382
326424011722	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
326424011723	2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy; cl15773
326424011724	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box protein; Region: CSP_CDS; cd04458
326424011725	DNA-binding site [nucleotide binding]; DNA binding site
326424011726	RNA-binding motif; other site
326424011727	Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600
326424011728	Na+/H+ antiporter, bacterial form; Region: a_cpa1; TIGR00831
326424011729	Na+/H+ antiporter, bacterial form; Region: a_cpa1; TIGR00831
326424011730	GAF domain; Region: GAF; cl15785
326424011731	Sigma factor PP2C-like phosphatases; Region: PP2C_SIG; smart00331
326424011732	Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cl00120
326424011733	ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073
326424011734	nylC-like family; composed of proteins with similarity to Flavobacterium endo-type 6-aminohexanoate-oligomer hydrolase (EIII), the product of the nylon oligomer degradation gene, nylC. EIII is an amide hydrolase that catalyzes the degradation of...; Region: nylC_like; cd02252
326424011735	putative active site pocket [active]
326424011736	cleavage site
326424011737	Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897
326424011738	Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448
326424011739	active site residue [active]
326424011740	Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449
326424011741	active site residue [active]
326424011742	Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381
326424011743	Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_2; cd03139
326424011744	Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693
326424011745	conserved cys residue [active]
326424011746	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567
326424011747	Sortase E (SrtE) is a membrane transpeptidase found in gram-positive bacteria that cleaves surface proteins at a cell sorting motif and catalyzes a transpeptidation reaction in which the surface protein substrate is covalently linked to peptidoglycan for...; Region: Sortase_E; cd05829
326424011748	active site
326424011749	putative catalytic site [active]
326424011750	Uncharacterized protein conserved in bacteria (DUF2252); Region: DUF2252; cl12088
326424011751	Stress responsive A/B Barrel Domain; Region: Dabb; cl15807
326424011752	Restriction endonuclease; Region: Mrr_cat; cl00516
326424011753	Predicted esterase [General function prediction only]; Region: COG0627
326424011754	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
326424011755	Streptomyces sporulation and cell division protein, SsgA; Region: SsgA; pfam04686
326424011756	Helix-turn-helix domains; Region: HTH; cl00088
326424011757	short chain dehydrogenase; Provisional; Region: PRK06180
326424011758	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
326424011759	NAD(P) binding site [chemical binding]; other site
326424011760	active site
326424011761	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761
326424011762	F420-dependent oxidoreductase, MSMEG_4879 family; Region: F420_MSMEG_4879; TIGR03564
326424011763	N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097
326424011764	FtsX-like permease family; Region: FtsX; cl15850
326424011765	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
326424011766	This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE).  They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255
326424011767	Walker A/P-loop; other site
326424011768	ATP binding site [chemical binding]; other site
326424011769	Q-loop/lid; other site
326424011770	ABC transporter signature motif; other site
326424011771	Walker B; other site
326424011772	D-loop; other site
326424011773	H-loop/switch region; other site
326424011774	YCII-related domain; Region: YCII; cl00999
326424011775	Predicted RNA polymerase sigma factor containing a TPR repeat domain [Transcription]; Region: COG4941
326424011776	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761
326424011777	Protein of unknown function (DUF1684); Region: DUF1684; cl01327
326424011778	putative FMN-dependent luciferase-like monooxygenase, KPN_01858 family; Region: LLM_KPN_01858; TIGR04027
326424011779	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
326424011780	hypothetical protein; Provisional; Region: PRK06126
326424011781	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
326424011782	nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095
326424011783	active site
326424011784	FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860
326424011785	non-prolyl cis peptide bond; other site
326424011786	ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123
326424011787	The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE).  The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257
326424011788	Walker A/P-loop; other site
326424011789	ATP binding site [chemical binding]; other site
326424011790	Q-loop/lid; other site
326424011791	ABC transporter signature motif; other site
326424011792	Walker B; other site
326424011793	D-loop; other site
326424011794	H-loop/switch region; other site
326424011795	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
326424011796	The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE).  The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257
326424011797	Walker A/P-loop; other site
326424011798	ATP binding site [chemical binding]; other site
326424011799	Q-loop/lid; other site
326424011800	ABC transporter signature motif; other site
326424011801	Walker B; other site
326424011802	D-loop; other site
326424011803	H-loop/switch region; other site
326424011804	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
326424011805	nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790
326424011806	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
326424011807	dimer interface [polypeptide binding]; other site
326424011808	conserved gate region; other site
326424011809	putative PBP binding loops; other site
326424011810	ABC-ATPase subunit interface; other site
326424011811	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
326424011812	dimer interface [polypeptide binding]; other site
326424011813	conserved gate region; other site
326424011814	putative PBP binding loops; other site
326424011815	ABC-ATPase subunit interface; other site
326424011816	The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_9; cd08496
326424011817	Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496
326424011818	Protein of unknown function (DUF1470); Region: DUF1470; pfam07336
326424011819	CGNR zinc finger; Region: zf-CGNR; pfam11706
326424011820	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
326424011821	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4529
326424011822	StaR_like; a well-conserved protein found in bacteria, plants, and animals. A family member from Streptomyces toyocaensis, StaR is part of a gene cluster involved in the biosynthesis of glycopeptide antibiotics (GPAs), specifically A47934. It has been...; Region: StaR_like; cd05804
326424011823	Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938
326424011824	Protein of unknown function (DUF2867); Region: DUF2867; pfam11066
326424011825	Helix-turn-helix domains; Region: HTH; cl00088
326424011826	Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819
326424011827	This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784
326424011828	homodimer interface [polypeptide binding]; other site
326424011829	active site
326424011830	TDP-binding site; other site
326424011831	Leucine carboxyl methyltransferase; Region: LCM; cl01306
326424011832	F420-dependent oxidoreductase, MSMEG_4879 family; Region: F420_MSMEG_4879; TIGR03564
326424011833	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
326424011834	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
326424011835	S-adenosylmethionine binding site [chemical binding]; other site
326424011836	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
326424011837	catalytic core [active]
326424011838	PQQ-dependent catabolism-associated beta-propeller protein; Region: PQQ_ABC_repeats; TIGR03866
326424011839	40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276
326424011840	40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276
326424011841	40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276
326424011842	40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276
326424011843	40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276
326424011844	NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025
326424011845	TIGR03442 family protein; Region: TIGR03442
326424011846	Glutamine amidotransferases class-II (Gn-AT)_YafJ-type.  YafJ is a glutamine amidotransferase-like protein of unknown function found in prokaryotes, eukaryotes and archaea.  YafJ has a conserved structural fold similar to those of other class II...; Region: YafJ; cd01908
326424011847	putative active site [active]
326424011848	putative dimer interface [polypeptide binding]; other site
326424011849	Glucoamylase and related glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: SGA1; COG3387
326424011850	Glycosyl hydrolases family 15; Region: Glyco_hydro_15; pfam00723
326424011851	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
326424011852	drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711
326424011853	Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396
326424011854	Short C-terminal domain; Region: SHOCT; cl01373
326424011855	Virulence factor BrkB; Region: Virul_fac_BrkB; cl07918
326424011856	Uncharacterized protein conserved in bacteria (DUF2252); Region: DUF2252; cl12088
326424011857	Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597
326424011858	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
326424011859	Type I restriction-modification system methyltransferase subunit [Defense mechanisms]; Region: HsdM; COG0286
326424011860	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
326424011861	Putative phage integrase; Region: Phage_Integr_2; pfam13009
326424011862	Winged helix-turn helix; Region: HTH_29; pfam13551
326424011863	Helix-turn-helix domains; Region: HTH; cl00088
326424011864	Integrase core domain; Region: rve; cl01316
326424011865	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
326424011866	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761
326424011867	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
326424011868	site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236
326424011869	phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189
326424011870	Int/Topo IB signature motif; other site
326424011871	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
326424011872	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
326424011873	Magnesium ion binding site [ion binding]; other site
326424011874	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
326424011875	non-specific DNA binding site [nucleotide binding]; other site
326424011876	salt bridge; other site
326424011877	sequence-specific DNA binding site [nucleotide binding]; other site
326424011878	S-adenosyl methyltransferase; Region: Methyltransf_19; pfam04672
326424011879	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761
326424011880	DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674
326424011881	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
326424011882	Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600
326424011883	Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600
326424011884	Frankia paralogous domain; Region: Frankia_40_dom; TIGR03917
326424011885	Site-specific recombinase XerD [DNA replication, recombination, and repair]; Region: XerD; COG4974
326424011886	phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189
326424011887	Int/Topo IB signature motif; other site
326424011888	S-adenosyl methyltransferase; Region: Methyltransf_19; pfam04672
326424011889	Helix-turn-helix domains; Region: HTH; cl00088
326424011890	Epoxide hydrolase N terminus; Region: EHN; pfam06441
326424011891	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
326424011892	Helix-turn-helix domains; Region: HTH; cl00088
326424011893	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
326424011894	pantoate--beta-alanine ligase; Region: panC; TIGR00018
326424011895	active site
326424011896	nucleotide binding site [chemical binding]; other site
326424011897	HIGH motif; other site
326424011898	KMSKS motif; other site
326424011899	Uncharacterized conserved protein related to dihydrodipicolinate reductase [Function unknown]; Region: COG3804
326424011900	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
326424011901	Type I periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type active transport systems that are predicted to be involved in transport of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_7; cd06341
326424011902	Periplasmic binding protein; Region: Peripla_BP_6; pfam13458
326424011903	putative ligand binding site [chemical binding]; other site
326424011904	Class III alcohol dehydrogenase; Region: Zn_ADH_class_III; cd08279
326424011905	Zn-dependent alcohol dehydrogenases, class III [Energy production and conversion]; Region: AdhC; COG1062
326424011906	NAD binding site [chemical binding]; other site
326424011907	catalytic Zn binding site [ion binding]; other site
326424011908	substrate binding site [chemical binding]; other site
326424011909	structural Zn binding site [ion binding]; other site
326424011910	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557
326424011911	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
326424011912	NAD(P) binding site [chemical binding]; other site
326424011913	active site
326424011914	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
326424011915	probable F420-dependent oxidoreductase, Rv2161c family; Region: F420_Rv2161c; TIGR03619
326424011916	Nitroreductase-like family 5.  A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_5; cd02148
326424011917	putative FMN binding site [chemical binding]; other site
326424011918	Sortase E (SrtE) is a membrane transpeptidase found in gram-positive bacteria that cleaves surface proteins at a cell sorting motif and catalyzes a transpeptidation reaction in which the surface protein substrate is covalently linked to peptidoglycan for...; Region: Sortase_E; cd05829
326424011919	active site
326424011920	putative catalytic site [active]
326424011921	Predicted metal-dependent hydrolase [General function prediction only]; Region: COG3687
326424011922	probable F420-dependent oxidoreductase, Rv1855c family; Region: F420_Rv1855c; TIGR03560
326424011923	N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097
326424011924	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761
326424011925	Luciferase-like monooxygenase; Region: Bac_luciferase; pfam00296
326424011926	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
326424011927	Helix-turn-helix domains; Region: HTH; cl00088
326424011928	Bacterial transcriptional regulator; Region: IclR; pfam01614
326424011929	glycolate oxidase, subunit GlcD; Region: glcD; TIGR00387
326424011930	FAD binding domain; Region: FAD_binding_4; pfam01565
326424011931	Pyruvate kinase (PK):  Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl09155
326424011932	active site
326424011933	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
326424011934	acetyl-CoA acetyltransferase; Provisional; Region: PRK07801
326424011935	dimer interface [polypeptide binding]; other site
326424011936	active site
326424011937	Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024
326424011938	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
326424011939	substrate binding site [chemical binding]; other site
326424011940	oxyanion hole (OAH) forming residues; other site
326424011941	trimer interface [polypeptide binding]; other site
326424011942	Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323
326424011943	Probable transposase; Region: OrfB_IS605; pfam01385
326424011944	ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555
326424011945	This family of ATP-binding proteins belongs to a multisubunit transporter involved in drug resistance (BcrA and DrrA), nodulation, lipid transport, and lantibiotic immunity.  In bacteria and archaea, these transporters usually include an ATP-binding...; Region: ABC_DR_subfamily_A; cd03230
326424011946	Walker A/P-loop; other site
326424011947	ATP binding site [chemical binding]; other site
326424011948	Q-loop/lid; other site
326424011949	ABC transporter signature motif; other site
326424011950	Walker B; other site
326424011951	D-loop; other site
326424011952	H-loop/switch region; other site
326424011953	Predicted transcriptional regulators [Transcription]; Region: COG1725
326424011954	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
326424011955	DNA-binding site [nucleotide binding]; DNA binding site
326424011956	Helix-turn-helix domains; Region: HTH; cl00088
326424011957	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; cl12078
326424011958	Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109
326424011959	TlpA-like family; composed of  TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966
326424011960	catalytic residues [active]
326424011961	Acyl-CoA dehydrogenase (ACAD) 10 and 11, N-terminal domain, and similar proteins. This subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: ACAD10_11_like; cd05154
326424011962	putative active site [active]
326424011963	ATP binding site [chemical binding]; other site
326424011964	TlpA-like family; composed of  TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966
326424011965	catalytic residues [active]
326424011966	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
326424011967	translocation protein TolB; Provisional; Region: tolB; PRK02889
326424011968	TIR domain; Region: TIR_2; cl15770
326424011969	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200
326424011970	structural tetrad; other site
326424011971	Domain of unknown function (DUF397); Region: DUF397; pfam04149
326424011972	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761
326424011973	Flavoprotein; Region: Flavoprotein; cl08021
326424011974	bifunctional SbtC-like/phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Provisional; Region: PRK13982
326424011975	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
326424011976	active site
326424011977	ATP binding site [chemical binding]; other site
326424011978	substrate binding site [chemical binding]; other site
326424011979	activation loop (A-loop); other site
326424011980	TIR domain; Region: TIR_2; cl15770
326424011981	Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277
326424011982	putative active site [active]
326424011983	Domain of unknown function DUF87; Region: DUF87; pfam01935
326424011984	AAA-like domain; Region: AAA_10; pfam12846
326424011985	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
326424011986	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
326424011987	Magnesium ion binding site [ion binding]; other site
326424011988	Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_24; cd04683
326424011989	nudix motif; other site
326424011990	Esterase-like activity of phytase; Region: Phytase-like; pfam13449
326424011991	putative acetyltransferase; Provisional; Region: PRK03624
326424011992	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
326424011993	Coenzyme A binding pocket [chemical binding]; other site
326424011994	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
326424011995	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
326424011996	Walker A motif; other site
326424011997	ATP binding site [chemical binding]; other site
326424011998	Walker B motif; other site
326424011999	arginine finger; other site
326424012000	Flavoprotein; Region: Flavoprotein; cl08021
326424012001	Putative sensor; Region: Sensor; pfam13796
326424012002	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585
326424012003	Histidine kinase; Region: HisKA_3; pfam07730
326424012004	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
326424012005	NAD(P) binding site [chemical binding]; other site
326424012006	active site
326424012007	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
326424012008	Helix-turn-helix domains; Region: HTH; cl00088
326424012009	Pyruvate kinase (PK):  Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl09155
326424012010	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
326424012011	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
326424012012	3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427
326424012013	Peptidase M50B-like; Region: Peptidase_M50B; pfam13398
326424012014	long-chain-fatty-acid--CoA ligase; Validated; Region: PRK08276
326424012015	AMP-binding enzyme; Region: AMP-binding; cl15778
326424012016	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
326424012017	Predicted oxidoreductases (related to aryl-alcohol dehydrogenases) [Energy production and conversion]; Region: Tas; COG0667
326424012018	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
326424012019	active site
326424012020	catalytic tetrad [active]
326424012021	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
326424012022	daunorubicin resistance ABC transporter ATP-binding subunit; Region: drrA; TIGR01188
326424012023	Walker A/P-loop; other site
326424012024	ATP binding site [chemical binding]; other site
326424012025	Q-loop/lid; other site
326424012026	ABC transporter signature motif; other site
326424012027	Walker B; other site
326424012028	D-loop; other site
326424012029	H-loop/switch region; other site
326424012030	Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; cl00986
326424012031	DinB superfamily; Region: DinB_2; pfam12867
326424012032	Streptomyces sporulation and cell division protein, SsgA; Region: SsgA; pfam04686
326424012033	Protein of unknown function (DUF3710); Region: DUF3710; pfam12502
326424012034	Mechanosensitive ion channel; Region: MS_channel; pfam00924
326424012035	Protein of unknown function (DUF1049); Region: DUF1049; cl01539
326424012036	Virulence factor BrkB; Region: Virul_fac_BrkB; cl07918
326424012037	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
326424012038	Ligand Binding Site [chemical binding]; other site
326424012039	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
326424012040	Catalytic domain of Protein Kinases; Region: PKc; cd00180
326424012041	active site
326424012042	ATP binding site [chemical binding]; other site
326424012043	substrate binding site [chemical binding]; other site
326424012044	activation loop (A-loop); other site
326424012045	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200
326424012046	structural tetrad; other site
326424012047	probable extracellular repeat, HAF family; Region: HAF_rpt; TIGR02913
326424012048	probable extracellular repeat, HAF family; Region: HAF_rpt; TIGR02913
326424012049	probable extracellular repeat, HAF family; Region: HAF_rpt; TIGR02913
326424012050	probable extracellular repeat, HAF family; Region: HAF_rpt; TIGR02913
326424012051	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
326424012052	Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024
326424012053	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
326424012054	substrate binding site [chemical binding]; other site
326424012055	oxyanion hole (OAH) forming residues; other site
326424012056	trimer interface [polypeptide binding]; other site
326424012057	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
326424012058	metal binding site [ion binding]; metal-binding site
326424012059	active site
326424012060	I-site; other site
326424012061	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
326424012062	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167
326424012063	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
326424012064	pyridoxal 5'-phosphate binding site [chemical binding]; other site
326424012065	homodimer interface [polypeptide binding]; other site
326424012066	catalytic residue [active]
326424012067	Periplasmic binding protein; Region: Peripla_BP_6; pfam13458
326424012068	Type I periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type active transport systems that are predicted to be involved in transport of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_7; cd06341
326424012069	putative ligand binding site [chemical binding]; other site
326424012070	TIGR03086 family protein; Region: TIGR03086
326424012071	Alkyl sulfatase and related hydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2015
326424012072	Helix-turn-helix domains; Region: HTH; cl00088
326424012073	WYL domain; Region: WYL; cl14852
326424012074	This CD, composed mainly of bacterial single-domain proteins, includes the Thermus thermophilus (Tt) YbaK-like protein, a homolog of the trans-acting Escherichia coli YbaK Cys-tRNA(Pro) deacylase and the Agrobacterium tumefaciens  ProX Ala-tRNA(Pro)...; Region: ProX_deacylase; cd04333
326424012075	putative deacylase active site [active]
326424012076	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
326424012077	classical (c) SDRs; Region: SDR_c; cd05233
326424012078	NAD(P) binding site [chemical binding]; other site
326424012079	active site
326424012080	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
326424012081	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
326424012082	ethanolamine ammonia lyase large subunit; Provisional; Region: PRK15067
326424012083	Ethanolamine ammonia lyase large subunit (EutB); Region: EutB; pfam06751
326424012084	Ethanolamine ammonia-lyase light chain (EutC); Region: EutC; cl01762
326424012085	TIR domain; Region: TIR_2; cl15770
326424012086	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
326424012087	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
326424012088	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
326424012089	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200
326424012090	structural tetrad; other site
326424012091	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200
326424012092	structural tetrad; other site
326424012093	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567
326424012094	NADPH-dependent FMN reductase; Region: FMN_red; cl00438
326424012095	Bacterial EndoU nuclease; Region: EndoU_bacteria; pfam14436
326424012096	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
326424012097	AAA domain; Region: AAA_33; pfam13671
326424012098	active site
326424012099	putative hydrolase, CocE/NonD family; Region: /NonD; TIGR00976
326424012100	X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; cl08482
326424012101	Helicase conserved C-terminal domain; Region: Helicase_C_3; pfam13625
326424012102	WYL domain; Region: WYL; cl14852
326424012103	CRISPR/Cas system-associated RAMP superfamily protein Cas6; Region: Cas6-I-III; cd09652
326424012104	CRISPR/Cas system-associated RAMP superfamily protein Cas7; Region: Cas7_I; cl00803
326424012105	CRISPR/Cas system-associated RAMP superfamily protein Cas5; Region: Cas5_I; cd09693
326424012106	CRISPR/Cas system-associated protein Cas3''; Region: Cas3''_I; cd09641
326424012107	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
326424012108	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
326424012109	CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641
326424012110	CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-B; cd09722
326424012111	CRISPR/Cas system-associated protein Cas2; Region: Cas2_I_II_III; cd09725
326424012112	helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346
326424012113	Helix-turn-helix domains; Region: HTH; cl00088
326424012114	Bacterial transcriptional regulator; Region: IclR; pfam01614
326424012115	Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer,  utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514
326424012116	S-adenosyl methyltransferase; Region: Methyltransf_19; pfam04672
326424012117	PemK-like protein; Region: PemK; cl00995
326424012118	similar to hypothetical protein; Evidence 4 : Homologs of previously reported genes of unknown function
326424012119	S-adenosyl methyltransferase; Region: Methyltransf_19; pfam04672
326424012120	Helix-turn-helix domains; Region: HTH; cl00088
326424012121	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator similar to DntR, which is involved in the catabolism of dinitrotoluene; contains the type 2 periplasmic binding fold; Region: PBP2_DntR_like_1; cd08460
326424012122	putative substrate binding pocket [chemical binding]; other site
326424012123	putative dimerization interface [polypeptide binding]; other site
326424012124	Siderophore-interacting protein [Inorganic ion transport and metabolism]; Region: ViuB; COG2375
326424012125	Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193
326424012126	FAD binding pocket [chemical binding]; other site
326424012127	FAD binding motif [chemical binding]; other site
326424012128	phosphate binding motif [ion binding]; other site
326424012129	NAD binding pocket [chemical binding]; other site
326424012130	Predicted O-methyltransferase [General function prediction only]; Region: COG4122
326424012131	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
326424012132	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
326424012133	short chain dehydrogenase; Provisional; Region: PRK06123
326424012134	NAD(P) binding site [chemical binding]; other site
326424012135	active site
326424012136	Putative neutral zinc metallopeptidase; Region: Zn_peptidase; cl00988
326424012137	Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109
326424012138	AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137
326424012139	transcriptional activator FtrA; Provisional; Region: ftrA; PRK09393
326424012140	conserved cys residue [active]
326424012141	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
326424012142	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
326424012143	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447
326424012144	nudix motif; other site
326424012145	tellurite resistance protein terB; Region: terB; cd07176
326424012146	putative metal binding site [ion binding]; other site
326424012147	SCP-2 sterol transfer family; Region: SCP2; cl01225
326424012148	PyridoxaL 5'-Phosphate Dependent Enzymes class IV (PLPDE_IV). This D-amino acid superfamily, one of five classes of PLPDE, consists of branched-chain amino acid aminotransferases (BCAT), D-amino acid transferases (DAAT), and 4-amino-4-deoxychorismate...; Region: PLPDE_IV; cl00224
326424012149	homodimer interface [polypeptide binding]; other site
326424012150	substrate-cofactor binding pocket; other site
326424012151	pyridoxal 5'-phosphate binding site [chemical binding]; other site
326424012152	catalytic residue [active]
326424012153	cyclase homology domain; Region: CHD; cd07302
326424012154	metal binding site [ion binding]; metal-binding site
326424012155	malate dehydrogenase; Provisional; Region: PRK05442
326424012156	Chloroplast-like malate dehydrogenases; Region: MDH_choloroplast_like; cd01338
326424012157	NAD(P) binding site [chemical binding]; other site
326424012158	dimer interface [polypeptide binding]; other site
326424012159	malate binding site [chemical binding]; other site
326424012160	Periplasmic binding protein; Region: Peripla_BP_6; pfam13458
326424012161	Type I periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type active transport systems that are predicted to be involved in transport of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_7; cd06341
326424012162	putative ligand binding site [chemical binding]; other site
326424012163	Rdx family; Region: Rdx; cl01407
326424012164	Domain of unknown function (DUF336); Region: DUF336; cl01249
326424012165	Domain of unknown function (DUF397); Region: DUF397; pfam04149
326424012166	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761
326424012167	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075
326424012168	DEAD-like helicases superfamily; Region: DEXDc; smart00487
326424012169	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
326424012170	ATP binding site [chemical binding]; other site
326424012171	putative Mg++ binding site [ion binding]; other site
326424012172	ATP-dependent RNA helicase HrpA; Provisional; Region: PRK11131
326424012173	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
326424012174	nucleotide binding region [chemical binding]; other site
326424012175	ATP-binding site [chemical binding]; other site
326424012176	Helicase associated domain (HA2); Region: HA2; cl04503
326424012177	Oligonucleotide/oligosaccharide-binding (OB)-fold; Region: OB_NTP_bind; pfam07717
326424012178	Domain of unknown function (DUF3418); Region: DUF3418; pfam11898
326424012179	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
326424012180	Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695
326424012181	galactokinase; Provisional; Region: PRK05101
326424012182	Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509
326424012183	GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544
326424012184	galactose-1-phosphate uridylyltransferase; Provisional; Region: PRK11720
326424012185	Galactose-1-phosphate uridyl transferase (GalT): This enzyme plays a key role in galactose metabolism by catalysing the transfer of a uridine 5'-phosphoryl group from UDP-galactose 1-phosphate. The structure of E.coli GalT reveals that the enzyme...; Region: GalT; cd00608
326424012186	dimer interface [polypeptide binding]; other site
326424012187	active site
326424012188	Bacterial protein of unknown function (DUF839); Region: DUF839; pfam05787
326424012189	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
326424012190	Helix-Turn-Helix DNA binding domain of the SoxR transcription regulator; Region: HTH_SoxR; cd01110
326424012191	Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789
326424012192	DNA binding residues [nucleotide binding]
326424012193	dimer interface [polypeptide binding]; other site
326424012194	[2Fe-2S] cluster binding site [ion binding]; other site
326424012195	NADPH-dependent FMN reductase; Region: FMN_red; cl00438
326424012196	Periplasmic binding protein; Region: Peripla_BP_6; pfam13458
326424012197	Type I periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type active transport systems that are predicted to be involved in transport of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_7; cd06341
326424012198	putative ligand binding site [chemical binding]; other site
326424012199	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
326424012200	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411
326424012201	The Mj1267/LivG ABC transporter subfamily is involved in the transport of the hydrophobic amino acids leucine, isoleucine and valine.  MJ1267 is a branched-chain amino acid transporter with 29% similarity to both the LivF and LivG components of the E; Region: ABC_Mj1267_LivG_branched; cd03219
326424012202	Walker A/P-loop; other site
326424012203	ATP binding site [chemical binding]; other site
326424012204	Q-loop/lid; other site
326424012205	ABC transporter signature motif; other site
326424012206	Walker B; other site
326424012207	D-loop; other site
326424012208	H-loop/switch region; other site
326424012209	Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974
326424012210	SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379
326424012211	CHAT domain; Region: CHAT; pfam12770
326424012212	AAA domain; Region: AAA_22; pfam13401
326424012213	Tetratricopeptide repeat; Region: TPR_12; pfam13424
326424012214	Tetratricopeptide repeat; Region: TPR_12; pfam13424
326424012215	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
326424012216	binding surface
326424012217	TPR motif; other site
326424012218	Tetratricopeptide repeat; Region: TPR_12; pfam13424
326424012219	Tetratricopeptide repeat; Region: TPR_12; pfam13424
326424012220	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
326424012221	binding surface
326424012222	TPR motif; other site
326424012223	Tetratricopeptide repeat; Region: TPR_12; pfam13424
326424012224	Tetratricopeptide repeat; Region: TPR_12; pfam13424
326424012225	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
326424012226	binding surface
326424012227	TPR motif; other site
326424012228	Tetratricopeptide repeat; Region: TPR_12; pfam13424
326424012229	Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228
326424012230	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
326424012231	active site
326424012232	Bacterial protein of unknown function (DUF839); Region: DUF839; pfam05787
326424012233	Glutamine amidotransferases class-II (GATase) asparagine synthase_B type.  Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a  glutaminase domain and a...; Region: AsnB; cd00712
326424012234	active site
326424012235	asparagine synthase (glutamine-hydrolyzing); Region: asn_synth_AEB; TIGR01536
326424012236	dimer interface [polypeptide binding]; other site
326424012237	The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B  catalyzes the...; Region: Asn_Synthase_B_C; cd01991
326424012238	Ligand Binding Site [chemical binding]; other site
326424012239	Molecular Tunnel; other site
326424012240	Pyoverdine/dityrosine biosynthesis protein; Region: DIT1_PvcA; pfam05141
326424012241	ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120
326424012242	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
326424012243	Walker A/P-loop; other site
326424012244	ATP binding site [chemical binding]; other site
326424012245	Q-loop/lid; other site
326424012246	ABC transporter signature motif; other site
326424012247	Walker B; other site
326424012248	D-loop; other site
326424012249	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
326424012250	dimer interface [polypeptide binding]; other site
326424012251	putative PBP binding regions; other site
326424012252	ABC-ATPase subunit  interface; other site
326424012253	Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+.  Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262
326424012254	intersubunit interface [polypeptide binding]; other site
326424012255	Fusaric acid resistance protein-like; Region: FUSC_2; cl15844
326424012256	DNA-binding transcriptional regulator CynR; Provisional; Region: PRK11242
326424012257	Helix-turn-helix domains; Region: HTH; cl00088
326424012258	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
326424012259	dimerization interface [polypeptide binding]; other site
326424012260	succinate dehydrogenase (or fumarate reductase) cytochrome b subunit, b558 family; Region: sdhC_b558_fam; TIGR02046
326424012261	Succinate:quinone oxidoreductase (SQR)-like Type B subfamily 2, transmembrane subunit; composed of proteins with similarity to the SQRs of Geobacter metallireducens and Corynebacterium glutamicum. SQR catalyzes the oxidation of succinate to fumarate...; Region: SQR_TypeB_2_TM; cd03498
326424012262	putative Iron-sulfur protein interface [polypeptide binding]; other site
326424012263	proximal heme binding site [chemical binding]; other site
326424012264	distal heme binding site [chemical binding]; other site
326424012265	putative dimer interface [polypeptide binding]; other site
326424012266	succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK07573
326424012267	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
326424012268	Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910
326424012269	succinate dehydrogenase/fumarate reductase iron-sulfur subunit; Validated; Region: PRK07570
326424012270	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cl00159
326424012271	4Fe-4S binding domain; Region: Fer4; cl02805
326424012272	D-amino acid dehydrogenase small subunit; Validated; Region: PRK00711
326424012273	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
326424012274	Protein of unknown function (DUF4012); Region: DUF4012; pfam13196
326424012275	Capsular polysaccharide biosynthesis protein [Cell envelope biogenesis, outer membrane]; Region: COG3944
326424012276	Chain length determinant protein; Region: Wzz; cl15801
326424012277	capsular exopolysaccharide family; Region: eps_fam; TIGR01007
326424012278	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
326424012279	Predicted nucleoside-diphosphate sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG1086
326424012280	UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237
326424012281	NAD(P) binding site [chemical binding]; other site
326424012282	homodimer interface [polypeptide binding]; other site
326424012283	substrate binding site [chemical binding]; other site
326424012284	active site
326424012285	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
326424012286	NAD(P) binding site [chemical binding]; other site
326424012287	active site
326424012288	sugar O-acyltransferase, sialic acid O-acetyltransferase NeuD family; Region: NeuD_NnaD; TIGR03570
326424012289	Putative Acyltransferase (AT), Left-handed parallel beta-Helix (LbH) domain; This group is composed of mostly uncharacterized proteins containing an N-terminal helical subdomain followed by a LbH domain. The alignment contains 6 turns, each containing...; Region: LbH_AT_putative; cd03360
326424012290	putative trimer interface [polypeptide binding]; other site
326424012291	putative CoA binding site [chemical binding]; other site
326424012292	Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr; Region: PTPc; cl00053
326424012293	Tyrosine phosphatase family C-terminal region; Region: Y_phosphatase3C; pfam13348
326424012294	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic 'goose-type' lysozymes (GEWL).  LTs catalyze...; Region: LT_GEWL; cd00254
326424012295	N-acetyl-D-glucosamine binding site [chemical binding]; other site
326424012296	catalytic residue [active]
326424012297	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cl09940
326424012298	Acyl transferase domain; Region: Acyl_transf_1; cl08282
326424012299	malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128
326424012300	3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352
326424012301	Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830
326424012302	dimer interface [polypeptide binding]; other site
326424012303	active site
326424012304	CoA binding pocket [chemical binding]; other site
326424012305	Phosphopantetheine attachment site; Region: PP-binding; cl09936
326424012306	Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834
326424012307	beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150
326424012308	dimer interface [polypeptide binding]; other site
326424012309	active site
326424012310	Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799
326424012311	Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl15772
326424012312	Transmembrane secretion effector; Region: MFS_3; pfam05977
326424012313	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
326424012314	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
326424012315	Walker A motif; other site
326424012316	ATP binding site [chemical binding]; other site
326424012317	Walker B motif; other site
326424012318	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
326424012319	ATP-dependent 26S proteasome regulatory subunit [Posttranslational modification, protein turnover, chaperones]; Region: RPT1; COG1222
326424012320	Peptidase family M41; Region: Peptidase_M41; pfam01434
326424012321	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
326424012322	active site
326424012323	molybdenum cofactor biosynthesis protein A; Reviewed; Region: moaA; PRK00164
326424012324	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
326424012325	FeS/SAM binding site; other site
326424012326	Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463
326424012327	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
326424012328	Protein of unknown function (DUF3071); Region: DUF3071; pfam11268
326424012329	Virulence factor BrkB; Region: Virul_fac_BrkB; cl07918
326424012330	Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581
326424012331	Aminopeptidase P, N-terminal domain; Region: AMP_N; cl08433
326424012332	proline aminopeptidase P II; Provisional; Region: PRK10879
326424012333	Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on...; Region: Prolidase; cd01087
326424012334	active site
326424012335	Lsr2; Region: Lsr2; pfam11774
326424012336	urea ABC transporter, ATP-binding protein UrtD; Region: urea_trans_UrtD; TIGR03411
326424012337	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
326424012338	PAS fold; Region: PAS_4; pfam08448
326424012339	putative active site [active]
326424012340	heme pocket [chemical binding]; other site
326424012341	PAS fold; Region: PAS_3; pfam08447
326424012342	GAF domain; Region: GAF; cl15785
326424012343	Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cl00120
326424012344	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075
326424012345	N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357
326424012346	Acyl-CoA synthetase (NDP forming) [Energy production and conversion]; Region: COG1042
326424012347	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
326424012348	CoA-ligase; Region: Ligase_CoA; cl02894
326424012349	ATP-grasp domain; Region: ATP-grasp_4; cl03087
326424012350	Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123
326424012351	Histone deacetylase domain; Region: Hist_deacetyl; cl02986
326424012352	acetoacetyl-CoA synthetase; Provisional; Region: PRK03584
326424012353	AMP-binding enzyme; Region: AMP-binding; cl15778
326424012354	RNA polymerase sigma factor RpoD; Validated; Region: PRK09210
326424012355	Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140
326424012356	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
326424012357	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
326424012358	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
326424012359	DNA binding residues [nucleotide binding]
326424012360	alpha-glucosidase; Provisional; Region: PRK10137
326424012361	Bacterial alpha-L-rhamnosidase; Region: Bac_rhamnosid; cl01801
326424012362	vitamin B12-dependent ribonucleotide reductase; Validated; Region: PRK06556
326424012363	Class II vitamin B12-dependent ribonucleotide reductase; Region: Ribonuc_red_2_N; pfam08471
326424012364	Class II ribonucleotide reductase, dimeric form; Region: RNR_II_dimer; cd02888
326424012365	active site
326424012366	dimer interface [polypeptide binding]; other site
326424012367	effector binding site; other site
326424012368	Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939
326424012369	TSCPD domain; Region: TSCPD; cl14834
326424012370	vitamin B12-dependent ribonucleotide reductase; Validated; Region: PRK06556
326424012371	ATP cone domain; Region: ATP-cone; pfam03477
326424012372	Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cl00107
326424012373	Helix-turn-helix domains; Region: HTH; cl00088
326424012374	LexA repressor; Validated; Region: PRK00215
326424012375	Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529
326424012376	Catalytic site [active]
326424012377	GTP-binding protein HflX; Region: GTP_HflX; TIGR03156
326424012378	GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167
326424012379	HflX GTPase family; Region: HflX; cd01878
326424012380	G1 box; other site
326424012381	GTP/Mg2+ binding site [chemical binding]; other site
326424012382	Switch I region; other site
326424012383	G2 box; other site
326424012384	G3 box; other site
326424012385	Switch II region; other site
326424012386	G4 box; other site
326424012387	G5 box; other site
326424012388	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
326424012389	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632
326424012390	active site
326424012391	metal binding site [ion binding]; metal-binding site
326424012392	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
326424012393	Diaminopimelate epimerase; Region: DAP_epimerase; cl14668
326424012394	Diaminopimelate epimerase; Region: DAP_epimerase; cl14668
326424012395	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
326424012396	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
326424012397	tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324
326424012398	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
326424012399	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
326424012400	The N-terminal domain, an extradiol dioxygenase class III subunit B-like domain, of unknown proteins containing a C-terminal AMMECR1 domain; Region: ED_3B_N_AMMECR1; cd07951
326424012401	(dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14326
326424012402	Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919
326424012403	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
326424012404	FeS/SAM binding site; other site
326424012405	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
326424012406	HisP and GlnQ are the ATP-binding components of the bacterial periplasmic histidine and glutamine permeases, repectively.  Histidine permease is a multisubunit complex containing the HisQ and HisM integral membrane subunits and two copies of HisP.  HisP...; Region: ABC_HisP_GlnQ_permeases; cd03262
326424012407	Walker A/P-loop; other site
326424012408	ATP binding site [chemical binding]; other site
326424012409	Q-loop/lid; other site
326424012410	ABC transporter signature motif; other site
326424012411	Walker B; other site
326424012412	D-loop; other site
326424012413	H-loop/switch region; other site
326424012414	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
326424012415	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
326424012416	substrate binding pocket [chemical binding]; other site
326424012417	membrane-bound complex binding site; other site
326424012418	hinge residues; other site
326424012419	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
326424012420	dimer interface [polypeptide binding]; other site
326424012421	conserved gate region; other site
326424012422	putative PBP binding loops; other site
326424012423	ABC-ATPase subunit interface; other site
326424012424	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
326424012425	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
326424012426	dimer interface [polypeptide binding]; other site
326424012427	conserved gate region; other site
326424012428	putative PBP binding loops; other site
326424012429	ABC-ATPase subunit interface; other site
326424012430	phosphodiesterase; Provisional; Region: PRK12704
326424012431	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076
326424012432	RecX family; Region: RecX; cl00936
326424012433	recombinase A; Provisional; Region: recA; PRK09354
326424012434	RecA is a  bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response.  RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983
326424012435	hexamer interface [polypeptide binding]; other site
326424012436	Walker A motif; other site
326424012437	ATP binding site [chemical binding]; other site
326424012438	Walker B motif; other site
326424012439	Protein of unknown function (DUF3046); Region: DUF3046; pfam11248
326424012440	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
326424012441	putative ATP-dependent helicase Lhr; Provisional; Region: PRK09751
326424012442	ATP binding site [chemical binding]; other site
326424012443	putative Mg++ binding site [ion binding]; other site
326424012444	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
326424012445	nucleotide binding region [chemical binding]; other site
326424012446	ATP-binding site [chemical binding]; other site
326424012447	DEAD/H associated; Region: DEAD_assoc; pfam08494
326424012448	putative ATP-dependent helicase Lhr; Provisional; Region: PRK09751
326424012449	drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711
326424012450	Formamidopyrimidine-DNA glycosylase [DNA replication, recombination, and repair]; Region: Nei; COG0266
326424012451	N-terminal domain of the actinomycetal Nei2 and related DNA glycosylases; Region: AcNei2_N; cd08971
326424012452	putative DNA binding site [nucleotide binding]; other site
326424012453	catalytic residue [active]
326424012454	putative H2TH interface [polypeptide binding]; other site
326424012455	putative catalytic residues [active]
326424012456	Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831
326424012457	RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
326424012458	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
326424012459	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761
326424012460	PspA/IM30 family; Region: PspA_IM30; pfam04012
326424012461	chaperone protein DnaJ; Region: DnaJ_bact; TIGR02349
326424012462	Ferritin-like domain; Region: Ferritin; pfam00210
326424012463	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761
326424012464	competence damage-inducible protein A; Provisional; Region: PRK00549
326424012465	Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885
326424012466	putative MPT binding site; other site
326424012467	Competence-damaged protein; Region: CinA; cl00666
326424012468	CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453
326424012469	ribosomal protein S12 methylthiotransferase RimO; Region: TIGR01125
326424012470	Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919
326424012471	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761
326424012472	Domain of unknown function (DUF4115); Region: DUF4115; pfam13464
326424012473	Domain of unknown function (DUF4117); Region: DUF4117; pfam13491
326424012474	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
326424012475	Ftsk gamma domain; Region: Ftsk_gamma; cl09645
326424012476	mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595
326424012477	Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446
326424012478	RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521
326424012479	Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950
326424012480	dihydrodipicolinate synthase; Region: dapA; TIGR00674
326424012481	dimer interface [polypeptide binding]; other site
326424012482	active site
326424012483	catalytic residue [active]
326424012484	Acetokinase family; Region: Acetate_kinase; cl01029
326424012485	Thymidylate synthase complementing protein; Region: Thy1; cl03630
326424012486	histidyl-tRNA synthetase; Region: hisS; TIGR00442
326424012487	Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: HisRS-like_core; cd00773
326424012488	dimer interface [polypeptide binding]; other site
326424012489	motif 1; other site
326424012490	active site
326424012491	motif 2; other site
326424012492	motif 3; other site
326424012493	Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004
326424012494	UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984
326424012495	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
326424012496	UDP-glucose 4-epimerase; Region: PLN02240
326424012497	UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247
326424012498	NAD binding site [chemical binding]; other site
326424012499	homodimer interface [polypeptide binding]; other site
326424012500	active site
326424012501	substrate binding site [chemical binding]; other site
326424012502	UDP-glucuronate decarboxylase (UGD) and related proteins, extended (e) SDRs; Region: UGD_SDR_e; cd05230
326424012503	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
326424012504	NAD binding site [chemical binding]; other site
326424012505	putative substrate binding site 2 [chemical binding]; other site
326424012506	putative substrate binding site 1 [chemical binding]; other site
326424012507	active site
326424012508	chaperone protein DnaK; Region: prok_dnaK; TIGR02350
326424012509	FGGY family of carbohydrate kinases; Region: FGGY; cl08364
326424012510	Hsp70 protein; Region: HSP70; pfam00012
326424012511	dihydrodipicolinate reductase; Provisional; Region: PRK00048
326424012512	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
326424012513	Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173
326424012514	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
326424012515	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
326424012516	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
326424012517	guanosine pentaphosphate synthetase I/polynucleotide phosphorylase; Region: pppGpp_PNP; TIGR02696
326424012518	Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363
326424012519	RNase E interface [polypeptide binding]; other site
326424012520	trimer interface [polypeptide binding]; other site
326424012521	Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726
326424012522	Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364
326424012523	RNase E interface [polypeptide binding]; other site
326424012524	trimer interface [polypeptide binding]; other site
326424012525	active site
326424012526	Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393
326424012527	putative nucleic acid binding region [nucleotide binding]; other site
326424012528	G-X-X-G motif; other site
326424012529	S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase  is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472
326424012530	RNA binding site [nucleotide binding]; other site
326424012531	domain interface; other site
326424012532	Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353
326424012533	16S/18S rRNA binding site [nucleotide binding]; other site
326424012534	S13e-L30e interaction site [polypeptide binding]; other site
326424012535	25S rRNA binding site [nucleotide binding]; other site
326424012536	bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627
326424012537	FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064
326424012538	active site
326424012539	Riboflavin kinase; Region: Flavokinase; cl03312
326424012540	tRNA pseudouridine synthase B; Provisional; Region: truB; PRK03287
326424012541	PseudoU_synth_EcTruB: Pseudouridine synthase, Escherichia coli TruB like. This group consists of bacterial pseudouridine synthases similar to E. coli TruB and Mycobacterium tuberculosis TruB. Pseudouridine synthases catalyze the isomerization of specific...; Region: PseudoU_synth_EcTruB; cd02573
326424012542	RNA binding site [nucleotide binding]; other site
326424012543	active site
326424012544	Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618
326424012545	Ribosome-binding factor A; Region: RBFA; cl00542
326424012546	Protein of unknown function (DUF503); Region: DUF503; cl00669
326424012547	Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760
326424012548	translation initiation factor IF-2; Region: IF-2; TIGR00487
326424012549	Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887
326424012550	G1 box; other site
326424012551	putative GEF interaction site [polypeptide binding]; other site
326424012552	GTP/Mg2+ binding site [chemical binding]; other site
326424012553	Switch I region; other site
326424012554	G2 box; other site
326424012555	G3 box; other site
326424012556	Switch II region; other site
326424012557	G4 box; other site
326424012558	G5 box; other site
326424012559	This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702
326424012560	Translation-initiation factor 2; Region: IF-2; pfam11987
326424012561	mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692
326424012562	Ylxr homologs; group of conserved hypothetical bacterial proteins of unknown function; structure revealed putative RNA binding cleft; proteins are encoded by an operon that includes other proteins involved in transcription and/or translation; Region: YlxR; cl00189
326424012563	transcription elongation factor NusA; Provisional; Region: nusA; PRK12327
326424012564	NusA N-terminal domain; Region: NusA_N; pfam08529
326424012565	S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455
326424012566	RNA binding site [nucleotide binding]; other site
326424012567	homodimer interface [polypeptide binding]; other site
326424012568	K homology RNA-binding domain, type I.  KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains that...; Region: KH-I; cl00098
326424012569	NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134
326424012570	G-X-X-G motif; other site
326424012571	The eukaryotic Sm and Sm-like (LSm) proteins associate with RNA to form the core domain of the ribonucleoprotein particles involved in a variety of RNA processing events including pre-mRNA splicing, telomere replication, and mRNA degradation.  Members of...; Region: Sm_like; cl00259
326424012572	The eukaryotic Sm and Sm-like (LSm) proteins associate with RNA to form the core domain of the ribonucleoprotein particles involved in a variety of RNA processing events including pre-mRNA splicing, telomere replication, and mRNA degradation.  Members of...; Region: Sm_like; cl00259
326424012573	Sm1 motif; other site
326424012574	D3 - B interaction site; other site
326424012575	D1 - D2 interaction site; other site
326424012576	Hfq - Hfq interaction site; other site
326424012577	RNA binding pocket [nucleotide binding]; other site
326424012578	Sm2 motif; other site
326424012579	Predicted transcriptional regulator [Transcription]; Region: COG1959
326424012580	Helix-turn-helix domains; Region: HTH; cl00088
326424012581	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427
326424012582	ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116
326424012583	NrtD and SsuB are the ATP-binding subunits of the bacterial ABC-type nitrate and sulfonate transport systems, respectively.  ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars; Region: ABC_NrtD_SsuB_transporters; cd03293
326424012584	Walker A/P-loop; other site
326424012585	ATP binding site [chemical binding]; other site
326424012586	Q-loop/lid; other site
326424012587	ABC transporter signature motif; other site
326424012588	Walker B; other site
326424012589	D-loop; other site
326424012590	H-loop/switch region; other site
326424012591	NMT1-like family; Region: NMT1_2; cl15260
326424012592	ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728
326424012593	Predicted acetyltransferase [General function prediction only]; Region: COG3393
326424012594	Domain of unknown function (DUF4081); Region: DUF4081; pfam13312
326424012595	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694
326424012596	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366
326424012597	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694
326424012598	Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020
326424012599	RIP metalloprotease RseP; Region: TIGR00054
326424012600	RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163
326424012601	active site
326424012602	active site
326424012603	PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989
326424012604	Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cd05709
326424012605	putative substrate binding region [chemical binding]; other site
326424012606	1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447
326424012607	1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670
326424012608	1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436
326424012609	DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288
326424012610	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
326424012611	ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK14459
326424012612	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
326424012613	FeS/SAM binding site; other site
326424012614	Cytidylyltransferase family; Region: CTP_transf_1; cl00347
326424012615	ribosome recycling factor; Reviewed; Region: frr; PRK00083
326424012616	Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation.  Thus ribosomes are 'recycled' and ready for another round of...; Region: RRF; cd00520
326424012617	hinge region; other site
326424012618	elongation factor Ts; Reviewed; Region: tsf; PRK12332
326424012619	Ubiquitin Associated domain. The UBA domain is a commonly occurring sequence motif in some members of the ubiquitination pathway, UV excision repair proteins, and certain protein kinases. Although its specific role is so far unknown, it has been...; Region: UBA; cl00153
326424012620	Elongation factor TS; Region: EF_TS; pfam00889
326424012621	Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425
326424012622	rRNA interaction site [nucleotide binding]; other site
326424012623	S8 interaction site; other site
326424012624	putative laminin-1 binding site; other site
326424012625	Peptidase family M23; Region: Peptidase_M23; pfam01551
326424012626	site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236
326424012627	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
326424012628	DNA binding site [nucleotide binding]
326424012629	Int/Topo IB signature motif; other site
326424012630	active site
326424012631	DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481
326424012632	Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695
326424012633	Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606
326424012634	Subunit ChlI of Mg-chelatase; Region: ChlI; cl12214
326424012635	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
326424012636	Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335
326424012637	Restriction endonuclease; Region: Mrr_cat; cl00516
326424012638	Protein of unknown function (DUF2469); Region: DUF2469; pfam10611
326424012639	bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182
326424012640	RNA/DNA hybrid binding site [nucleotide binding]; other site
326424012641	active site
326424012642	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
326424012643	Catalytic site [active]
326424012644	Ribosomal protein L19; Region: Ribosomal_L19; cl00406
326424012645	tRNA (Guanine-1)-methyltransferase; Region: tRNA_m1G_MT; cl00407
326424012646	16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122
326424012647	RimM N-terminal domain; Region: RimM; pfam01782
326424012648	Photosynthetic reaction center (RC) complex, subunit H;  RC is an integral membrane protein-pigment complex which catalyzes light-induced reduction of ubiquinone to ubiquinol, generating a transmembrane electrochemical gradient of protons used to produce...; Region: PRCH; cl09959
326424012649	Ribosomal protein S16; Region: Ribosomal_S16; cl00368
326424012650	signal recognition particle protein; Provisional; Region: PRK10867
326424012651	SRP54-type protein, helical bundle domain; Region: SRP54_N; cl03758
326424012652	The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115
326424012653	GTP binding site [chemical binding]; other site
326424012654	Signal peptide binding domain; Region: SRP_SPB; pfam02978
326424012655	signal recognition particle-docking protein FtsY; Region: ftsY; TIGR00064
326424012656	SRP54-type protein, helical bundle domain; Region: SRP54_N; cl03758
326424012657	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
326424012658	chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168
326424012659	Barmotin is a tight junction-associated protein expressed in rat epithelial cells which is thought to have an important regulatory role in tight junction barrier function.  Barmotin belongs to the SMC protein family. SMC proteins are large; Region: ABC_SMC_barmotin; cd03278
326424012660	Walker A/P-loop; other site
326424012661	ATP binding site [chemical binding]; other site
326424012662	chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168
326424012663	Barmotin is a tight junction-associated protein expressed in rat epithelial cells which is thought to have an important regulatory role in tight junction barrier function.  Barmotin belongs to the SMC protein family. SMC proteins are large; Region: ABC_SMC_barmotin; cd03278
326424012664	ABC transporter signature motif; other site
326424012665	Walker B; other site
326424012666	D-loop; other site
326424012667	H-loop/switch region; other site
326424012668	Acylphosphatase; Region: Acylphosphatase; cl00551
326424012669	Protein of unknown function (DUF2786); Region: DUF2786; pfam10979
326424012670	formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103
326424012671	N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966
326424012672	DNA binding site [nucleotide binding]
326424012673	catalytic residue [active]
326424012674	H2TH interface [polypeptide binding]; other site
326424012675	putative catalytic residues [active]
326424012676	turnover-facilitating residue; other site
326424012677	intercalation triad [nucleotide binding]; other site
326424012678	8OG recognition residue [nucleotide binding]; other site
326424012679	putative reading head residues; other site
326424012680	Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831
326424012681	Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827
326424012682	RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593
326424012683	dimerization interface [polypeptide binding]; other site
326424012684	active site
326424012685	metal binding site [ion binding]; metal-binding site
326424012686	Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048
326424012687	Phosphate acetyl/butaryl transferase; Region: PTA_PTB; cl00390
326424012688	Uncharacterized ACR, COG1399; Region: DUF177; cl00616
326424012689	phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168
326424012690	Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163
326424012691	active site
326424012692	(T/H)XGH motif; other site
326424012693	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
326424012694	S-adenosylmethionine binding site [chemical binding]; other site
326424012695	ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917
326424012696	RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488
326424012697	generic binding surface II; other site
326424012698	ssDNA binding site; other site
326424012699	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
326424012700	ATP binding site [chemical binding]; other site
326424012701	putative Mg++ binding site [ion binding]; other site
326424012702	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
326424012703	nucleotide binding region [chemical binding]; other site
326424012704	ATP-binding site [chemical binding]; other site
326424012705	Ribosomal L28 family; Region: Ribosomal_L28; cl00367
326424012706	Domain of unknown function (DUF222); Region: DUF222; pfam02720
326424012707	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
326424012708	active site
326424012709	D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966
326424012710	D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820
326424012711	ATP-grasp domain; Region: ATP-grasp_4; cl03087
326424012712	Protein of unknown function (DUF3515); Region: DUF3515; pfam12028
326424012713	Helix-turn-helix domains; Region: HTH; cl00088
326424012714	4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169
326424012715	dimer interface [polypeptide binding]; other site
326424012716	substrate binding site [chemical binding]; other site
326424012717	ATP binding site [chemical binding]; other site
326424012718	UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072
326424012719	UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555
326424012720	hinge; other site
326424012721	active site
326424012722	NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094
326424012723	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
326424012724	NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479
326424012725	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
326424012726	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
326424012727	metal binding site [ion binding]; metal-binding site
326424012728	active site
326424012729	I-site; other site
326424012730	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
326424012731	Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379
326424012732	Transglutaminase-like superfamily; Region: Transglut_core; cl10469
326424012733	polyphosphate kinase; Provisional; Region: PRK05443
326424012734	Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089
326424012735	Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503
326424012736	Catalytic C-terminal domain, first repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C1_like; cd09165
326424012737	putative domain interface [polypeptide binding]; other site
326424012738	putative active site [active]
326424012739	catalytic site [active]
326424012740	Catalytic C-terminal domain, second repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C2_like; cd09168
326424012741	putative domain interface [polypeptide binding]; other site
326424012742	putative active site [active]
326424012743	catalytic site [active]
326424012744	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
326424012745	IHF dimer interface [polypeptide binding]; other site
326424012746	IHF - DNA interface [nucleotide binding]; other site
326424012747	Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577
326424012748	substrate binding site [chemical binding]; other site
326424012749	3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402
326424012750	3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583
326424012751	substrate binding site [chemical binding]; other site
326424012752	ligand binding site [chemical binding]; other site
326424012753	Transcriptional regulator [Transcription]; Region: IclR; COG1414
326424012754	Helix-turn-helix domains; Region: HTH; cl00088
326424012755	Bacterial transcriptional regulator; Region: IclR; pfam01614
326424012756	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
326424012757	Catalytic domain of Protein Kinases; Region: PKc; cd00180
326424012758	active site
326424012759	ATP binding site [chemical binding]; other site
326424012760	substrate binding site [chemical binding]; other site
326424012761	activation loop (A-loop); other site
326424012762	PASTA domain. This domain is found at the C-termini of several Penicillin-binding proteins (PBPs) and bacterial serine/threonine kinases. It is a small globular fold consisting of 3 beta-sheets and an alpha-helix. The name PASTA is derived from PBP and...; Region: PASTA; cl02768
326424012763	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
326424012764	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
326424012765	dimer interface [polypeptide binding]; other site
326424012766	phosphorylation site [posttranslational modification]
326424012767	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
326424012768	ATP binding site [chemical binding]; other site
326424012769	Mg2+ binding site [ion binding]; other site
326424012770	G-X-G motif; other site
326424012771	Domain of unknown function (DUF2437); Region: DUF2437; pfam10370
326424012772	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421
326424012773	putative alpha-isopropylmalate/homocitrate synthase family transferase; Provisional; Region: PRK12344
326424012774	Desulfobacterium autotrophicum LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA3; cd07941
326424012775	active site
326424012776	catalytic residues [active]
326424012777	metal binding site [ion binding]; metal-binding site
326424012778	LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; cl07212
326424012779	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
326424012780	CRP/FNR family transcriptional regulator; Provisional; Region: PRK13918
326424012781	ligand binding site [chemical binding]; other site
326424012782	flexible hinge region; other site
326424012783	Helix-turn-helix domains; Region: HTH; cl00088
326424012784	FOG: CBS domain [General function prediction only]; Region: COG0517
326424012785	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_11; cd04624
326424012786	BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids  leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557
326424012787	homodimer interface [polypeptide binding]; other site
326424012788	substrate-cofactor binding pocket; other site
326424012789	catalytic residue [active]
326424012790	Isocitrate/isopropylmalate dehydrogenase; Region: Iso_dh; cl00445
326424012791	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
326424012792	Protein of unknown function (DUF1059); Region: DUF1059; cl02284
326424012793	2-isopropylmalate synthase; Validated; Region: PRK03739
326424012794	Mycobacterium tuberculosis LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA; cd07942
326424012795	active site
326424012796	catalytic residues [active]
326424012797	metal binding site [ion binding]; metal-binding site
326424012798	LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; cl07212
326424012799	Septum formation; Region: Septum_form; pfam13845
326424012800	D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK13581
326424012801	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
326424012802	C-terminal ACT (regulatory) domain of D-3-phosphoglycerate dehydrogenase (3PGDH); Region: ACT_3PGDH-xct; cd04902
326424012803	putative L-serine binding site [chemical binding]; other site
326424012804	ketol-acid reductoisomerase; Provisional; Region: PRK05479
326424012805	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
326424012806	Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450
326424012807	acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895
326424012808	N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878
326424012809	putative valine binding site [chemical binding]; other site
326424012810	dimer interface [polypeptide binding]; other site
326424012811	Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369
326424012812	acetolactate synthase 1 catalytic subunit; Validated; Region: PRK07789
326424012813	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
326424012814	PYR/PP interface [polypeptide binding]; other site
326424012815	dimer interface [polypeptide binding]; other site
326424012816	TPP binding site [chemical binding]; other site
326424012817	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; cl00815
326424012818	Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015
326424012819	TPP-binding site [chemical binding]; other site
326424012820	dimer interface [polypeptide binding]; other site
326424012821	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
326424012822	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009
326424012823	aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477
326424012824	GatB/GatE catalytic domain; Region: GatB_N; pfam02934
326424012825	GatB domain; Region: GatB_Yqey; cl11497
326424012826	Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154
326424012827	Amidase; Region: Amidase; cl11426
326424012828	Glu-tRNAGln amidotransferase C subunit; Region: Glu-tRNAGln; cl00495
326424012829	ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141
326424012830	NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956
326424012831	NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114
326424012832	nucleotide binding pocket [chemical binding]; other site
326424012833	K-X-D-G motif; other site
326424012834	catalytic site [active]
326424012835	NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120
326424012836	NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119
326424012837	Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027
326424012838	Dimer interface [polypeptide binding]; other site
326424012839	CIMS - Cobalamine-independent methonine synthase, or MetE. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme catalyses the last step in...; Region: CIMS_like; cd03310
326424012840	tRNA methyl transferase; Region: tRNA_Me_trans; pfam03054
326424012841	tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998
326424012842	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
326424012843	cysteine desulfurase DndA; Region: DNA_S_dndA; TIGR03235
326424012844	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
326424012845	active site
326424012846	Helix-turn-helix domains; Region: HTH; cl00088
326424012847	methylmalonyl CoA mutase B12 binding domain. This domain binds to B12 (adenosylcobamide), which initiates the conversion of succinyl CoA and methylmalonyl CoA by forming an adenosyl radical, which then undergoes a rearrangement exchanging a hydrogen atom...; Region: MM_CoA_mut_B12_BD; cd02071
326424012848	B12 binding site [chemical binding]; other site
326424012849	cobalt ligand [ion binding]; other site
326424012850	Putative periplasmic protein kinase ArgK and related GTPases of G3E family [Amino acid transport and metabolism]; Region: ArgK; COG1703
326424012851	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
326424012852	Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM)-like family; contains proteins similar to MCM, and the large subunit of Streptomyces coenzyme B12-dependent isobutyryl-CoA mutase (ICM). MCM catalyzes the isomerization of...; Region: MM_CoA_mutase; cl00817
326424012853	Methylmalonyl-CoA mutase, N-terminal domain/subunit [Lipid metabolism]; Region: Sbm; COG1884
326424012854	Creatinine amidohydrolase; Region: Creatininase; cl00618
326424012855	classical (c) SDRs; Region: SDR_c; cd05233
326424012856	NAD(P) binding site [chemical binding]; other site
326424012857	active site
326424012858	FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121
326424012859	FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121
326424012860	Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025
326424012861	Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which  binds to Adenosine nucleotide; Region: AANH_like; cl00292
326424012862	Ligand Binding Site [chemical binding]; other site
326424012863	Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766
326424012864	The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714
326424012865	Ligand binding site [chemical binding]; other site
326424012866	Electron transfer flavoprotein domain; Region: ETF; pfam01012
326424012867	Bacterial Micro-Compartment (BMC) domain; Region: BMC; cl01982
326424012868	Hexamer interface [polypeptide binding]; other site
326424012869	Hexagonal pore residue; other site
326424012870	Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490
326424012871	putative catalytic site [active]
326424012872	putative metal binding site [ion binding]; other site
326424012873	putative phosphate binding site [ion binding]; other site
326424012874	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
326424012875	enoyl-CoA hydratase; Provisional; Region: PRK07657
326424012876	substrate binding site [chemical binding]; other site
326424012877	oxyanion hole (OAH) forming residues; other site
326424012878	trimer interface [polypeptide binding]; other site
326424012879	glycogen debranching enzyme GlgX; Region: glgX_debranch; TIGR02100
326424012880	N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856
326424012881	Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326
326424012882	active site
326424012883	catalytic site [active]
326424012884	This family is most closely related to the oligosaccharide phosphorylase domain family and other unidentified sequences. Oligosaccharide phosphorylase catalyzes the breakdown of oligosaccharides into glucose-1-phosphate units. They are important...; Region: GT1_Glycogen_Phosphorylase_like; cd04299
326424012885	putative homodimer interface [polypeptide binding]; other site
326424012886	putative active site pocket [active]
326424012887	alpha-glucan phosphorylases; Region: more_P_ylases; TIGR02094
326424012888	Domain of unknown function (DUF3448); Region: DUF3448; pfam11930
326424012889	acetyl-CoA synthetase; Provisional; Region: PRK00174
326424012890	AMP-binding enzyme; Region: AMP-binding; cl15778
326424012891	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
326424012892	mannosyl-3-phosphoglycerate phosphatase family; Region: HAD-SF-IIB-MPGP; TIGR01486
326424012893	Protein of unknown function (DUF2983); Region: DUF2983; pfam11202
326424012894	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cl00309
326424012895	Protein of unknown function (DUF3706); Region: DUF3706; pfam12500
326424012896	Pyruvate kinase (PK):  Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl09155
326424012897	Double zinc ribbon; Region: DZR; pfam12773
326424012898	Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063
326424012899	Interdomain contacts; other site
326424012900	Cytokine receptor motif; other site
326424012901	Hsp70 protein; Region: HSP70; pfam00012
326424012902	GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cl03075
326424012903	Uncharacterized protein involved in stress response [General function prediction only]; Region: COG4110
326424012904	Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974
326424012905	putative metal binding site [ion binding]; other site
326424012906	Integral membrane protein TerC family; Region: TerC; cl10468
326424012907	Uncharacterized proteins involved in stress response, homologs of TerZ and putative cAMP-binding protein CABP1 [Signal transduction mechanisms]; Region: TerZ; COG2310
326424012908	Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974
326424012909	putative metal binding site [ion binding]; other site
326424012910	Domain of unknown function (DUF3416); Region: DUF3416; pfam11896
326424012911	Alpha amylase catalytic domain found in GlgE-like proteins; Region: AmyAc_GlgE_like; cd11344
326424012912	active site
326424012913	homodimer interface [polypeptide binding]; other site
326424012914	catalytic site [active]
326424012915	acceptor binding site [chemical binding]; other site
326424012916	trehalose synthase; Region: treS_nterm; TIGR02456
326424012917	Alpha amylase catalytic domain found in Trehalose synthetase; Region: AmyAc_TreS; cd11334
326424012918	active site
326424012919	catalytic site [active]
326424012920	Uncharacterized protein, probably involved in trehalose biosynthesis [Carbohydrate transport and metabolism]; Region: Ble; cl01286
326424012921	glycogen branching enzyme; Provisional; Region: PRK05402
326424012922	Early set domain associated with the catalytic domain of sugar utilizing enzymes at either the N or C terminus; Region: E_set; cl09101
326424012923	N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855
326424012924	Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322
326424012925	active site
326424012926	catalytic site [active]
326424012927	Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; cl02706
326424012928	Thioredoxin domain-containing protein [Posttranslational modification, protein turnover, chaperones]; Region: COG3118
326424012929	ybbN protein family; ybbN is a hypothetical protein containing a redox-inactive TRX-like domain. Its gene has been sequenced from several gammaproteobacteria and actinobacteria; Region: ybbN; cd02956
326424012930	Domain of unknown function DUF77; Region: DUF77; cl00307
326424012931	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
326424012932	dimer interface [polypeptide binding]; other site
326424012933	phosphorylation site [posttranslational modification]
326424012934	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
326424012935	ATP binding site [chemical binding]; other site
326424012936	Mg2+ binding site [ion binding]; other site
326424012937	G-X-G motif; other site
326424012938	Response regulator receiver domain; Region: Response_reg; pfam00072
326424012939	Cupin superfamily (DUF985); Region: Cupin_5; cl01418
326424012940	Putative periplasmic protein kinase ArgK and related GTPases of G3E family [Amino acid transport and metabolism]; Region: ArgK; COG1703
326424012941	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
326424012942	putative acyltransferase; Provisional; Region: PRK05790
326424012943	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
326424012944	dimer interface [polypeptide binding]; other site
326424012945	active site
326424012946	Family description; Region: VCBS; pfam13517
326424012947	RNA polymerase sigma-70 factor, sigma-E family; Region: SigE-fam_strep; TIGR02983
326424012948	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
326424012949	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
326424012950	DNA binding residues [nucleotide binding]
326424012951	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
326424012952	crotonyl-CoA reductase; Region: crot-CoA-red; TIGR01751
326424012953	NAD(P) binding site [chemical binding]; other site
326424012954	Protein of unknown function (DUF1232); Region: DUF1232; cl01318
326424012955	3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK07819
326424012956	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
326424012957	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
326424012958	3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK07819
326424012959	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
326424012960	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
326424012961	Protein of unknown function DUF91; Region: DUF91; cl00709
326424012962	Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317
326424012963	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076
326424012964	Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM)-like family; contains proteins similar to MCM, and the large subunit of Streptomyces coenzyme B12-dependent isobutyryl-CoA mutase (ICM). MCM catalyzes the isomerization of...; Region: MM_CoA_mutase; cl00817
326424012965	methylmalonyl CoA mutase B12 binding domain. This domain binds to B12 (adenosylcobamide), which initiates the conversion of succinyl CoA and methylmalonyl CoA by forming an adenosyl radical, which then undergoes a rearrangement exchanging a hydrogen atom...; Region: MM_CoA_mut_B12_BD; cd02071
326424012966	B12 binding site [chemical binding]; other site
326424012967	cobalt ligand [ion binding]; other site
326424012968	Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043
326424012969	anti sigma factor interaction site; other site
326424012970	regulatory phosphorylation site [posttranslational modification]; other site
326424012971	UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072
326424012972	UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555
326424012973	hinge; other site
326424012974	active site
326424012975	Cobalamin adenosyltransferase; Region: Cob_adeno_trans; cl00920
326424012976	PemK-like protein; Region: PemK; cl00995
326424012977	ATP synthase, Delta/Epsilon chain, beta-sandwich domain; Region: ATP-synt_DE_N; cl10033
326424012978	F0F1 ATP synthase subunit beta; Validated; Region: PRK09280
326424012979	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; cl15275
326424012980	F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133
326424012981	alpha subunit interaction interface [polypeptide binding]; other site
326424012982	Walker A motif; other site
326424012983	ATP binding site [chemical binding]; other site
326424012984	Walker B motif; other site
326424012985	inhibitor binding site; inhibition site
326424012986	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
326424012987	ATP synthase; Region: ATP-synt; cl00365
326424012988	F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281
326424012989	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; cl15275
326424012990	F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132
326424012991	beta subunit interaction interface [polypeptide binding]; other site
326424012992	Walker A motif; other site
326424012993	ATP binding site [chemical binding]; other site
326424012994	Walker B motif; other site
326424012995	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
326424012996	Plant ATP synthase F0; Region: YMF19; cl07975
326424012997	Plant ATP synthase F0; Region: YMF19; cl07975
326424012998	F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711
326424012999	ATP synthase subunit C; Region: ATP-synt_C; cl00466
326424013000	ATP synthase A chain; Region: ATP-synt_A; cl00413
326424013001	UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472
326424013002	This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853
326424013003	Mg++ binding site [ion binding]; other site
326424013004	putative catalytic motif [active]
326424013005	substrate binding site [chemical binding]; other site
326424013006	serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011
326424013007	Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378
326424013008	dimer interface [polypeptide binding]; other site
326424013009	glycine-pyridoxal phosphate binding site [chemical binding]; other site
326424013010	active site
326424013011	folate binding site [chemical binding]; other site
326424013012	Telomere recombination; Region: Sua5_yciO_yrdC; cl00305
326424013013	N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328
326424013014	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
326424013015	peptide chain release factor 1; Validated; Region: prfA; PRK00591
326424013016	RF-1 domain; Region: RF-1; cl02875
326424013017	RF-1 domain; Region: RF-1; cl02875
326424013018	Ribosomal protein L31; Region: Ribosomal_L31; cl00377
326424013019	Rho termination factor, N-terminal domain; Region: Rho_N; cl06505
326424013020	transcription termination factor Rho; Provisional; Region: PRK12608
326424013021	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
326424013022	RNA binding site [nucleotide binding]; other site
326424013023	Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128
326424013024	multimer interface [polypeptide binding]; other site
326424013025	Walker A motif; other site
326424013026	ATP binding site [chemical binding]; other site
326424013027	Walker B motif; other site
326424013028	homoserine kinase; Provisional; Region: PRK01212
326424013029	homoserine kinase; Provisional; Region: PRK01212
326424013030	threonine synthase; Reviewed; Region: PRK06721
326424013031	Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of  threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants; Region: Thr-synth_1; cd01563
326424013032	homodimer interface [polypeptide binding]; other site
326424013033	pyridoxal 5'-phosphate binding site [chemical binding]; other site
326424013034	catalytic residue [active]
326424013035	homoserine dehydrogenase; Provisional; Region: PRK06349
326424013036	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
326424013037	Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742
326424013038	ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881
326424013039	diaminopimelate decarboxylase; Region: lysA; TIGR01048
326424013040	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828
326424013041	active site
326424013042	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
326424013043	substrate binding site [chemical binding]; other site
326424013044	catalytic residues [active]
326424013045	dimer interface [polypeptide binding]; other site
326424013046	arginyl-tRNA synthetase; Reviewed; Region: argS; PRK01611
326424013047	Arginyl tRNA synthetase N terminal domain; Region: Arg_tRNA_synt_N; cl04104
326424013048	catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671
326424013049	active site
326424013050	HIGH motif; other site
326424013051	KMSK motif region; other site
326424013052	Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020
326424013053	tRNA binding surface [nucleotide binding]; other site
326424013054	anticodon binding site; other site
326424013055	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
326424013056	active site
326424013057	phosphorylation site [posttranslational modification]
326424013058	intermolecular recognition site; other site
326424013059	dimerization interface [polypeptide binding]; other site
326424013060	Predicted membrane protein (DUF2127); Region: DUF2127; cl01785
326424013061	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
326424013062	MSMEG_0572 family protein; Region: MSMEG_0572_fam; TIGR04044
326424013063	radical SAM protein, MSMEG_0568 family; Region: rSAM_MSMEG_0568; TIGR04043
326424013064	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cl15377
326424013065	N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357
326424013066	AIR synthase (PurM) related protein, subgroup 3 of unknown function. The family of PurM related proteins includes Hydrogen expression/formation protein HypE, AIR synthases, FGAM synthase and Selenophosphate synthetase (SelD). They all contain two...; Region: PurM-like3; cd02192
326424013067	dimerization interface [polypeptide binding]; other site
326424013068	putative ATP binding site [chemical binding]; other site
326424013069	Predicted amidohydrolase [General function prediction only]; Region: COG0388
326424013070	Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cd07197
326424013071	active site
326424013072	catalytic triad [active]
326424013073	dimer interface [polypeptide binding]; other site
326424013074	flavin-dependent oxidoreductase, MSMEG_0569 family; Region: MSMEG_0569_nitr; TIGR04046
326424013075	glycosyltransferase, MSMEG_0565 family; Region: MSMEG_0565_glyc; TIGR04047
326424013076	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
326424013077	Helix-turn-helix domains; Region: HTH; cl00088
326424013078	Peptidase family M48; Region: Peptidase_M48; cl12018
326424013079	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
326424013080	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
326424013081	metal binding site [ion binding]; metal-binding site
326424013082	active site
326424013083	I-site; other site
326424013084	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
326424013085	N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357
326424013086	7-keto-8-aminopelargonate synthetase and related enzymes [Coenzyme metabolism]; Region: BioF; COG0156
326424013087	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
326424013088	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
326424013089	catalytic residue [active]
326424013090	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
326424013091	S-adenosylmethionine binding site [chemical binding]; other site
326424013092	PHP family phosphoesterase with a Zn ribbon [General function prediction only]; Region: COG1379
326424013093	Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210
326424013094	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
326424013095	DNA helicase II; Region: uvrD; TIGR01075
326424013096	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
326424013097	Family description; Region: UvrD_C_2; cl15862
326424013098	Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277
326424013099	putative active site [active]
326424013100	Acetamidase/Formamidase family; Region: FmdA_AmdA; cl01023
326424013101	thiamine monophosphate kinase; Provisional; Region: PRK05731
326424013102	ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194
326424013103	ATP binding site [chemical binding]; other site
326424013104	dimerization interface [polypeptide binding]; other site
326424013105	alpha-ketoglutarate decarboxylase; Reviewed; Region: kgd; PRK12270
326424013106	alpha-ketoglutarate decarboxylase; Reviewed; Region: kgd; PRK12270
326424013107	2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; cl02008
326424013108	Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016
326424013109	TPP-binding site [chemical binding]; other site
326424013110	Pyrimidine (PYR) binding domain of thiamine pyrophosphate (TPP)-dependent enzymes; Region: TPP_enzyme_PYR; cl11410
326424013111	NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604
326424013112	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
326424013113	NAD(P) binding site [chemical binding]; other site
326424013114	Malic enzyme, N-terminal domain; Region: malic; pfam00390
326424013115	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
326424013116	NAD(P) binding pocket [chemical binding]; other site
326424013117	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
326424013118	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
326424013119	substrate binding pocket [chemical binding]; other site
326424013120	membrane-bound complex binding site; other site
326424013121	hinge residues; other site
326424013122	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
326424013123	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
326424013124	dimer interface [polypeptide binding]; other site
326424013125	conserved gate region; other site
326424013126	putative PBP binding loops; other site
326424013127	ABC-ATPase subunit interface; other site
326424013128	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
326424013129	HisP and GlnQ are the ATP-binding components of the bacterial periplasmic histidine and glutamine permeases, repectively.  Histidine permease is a multisubunit complex containing the HisQ and HisM integral membrane subunits and two copies of HisP.  HisP...; Region: ABC_HisP_GlnQ_permeases; cd03262
326424013130	Walker A/P-loop; other site
326424013131	ATP binding site [chemical binding]; other site
326424013132	Q-loop/lid; other site
326424013133	ABC transporter signature motif; other site
326424013134	Walker B; other site
326424013135	D-loop; other site
326424013136	H-loop/switch region; other site
326424013137	Cupin domain; Region: Cupin_2; cl09118
326424013138	N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357
326424013139	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075
326424013140	RNA polymerase sigma-70 factor, sigma-B/F/G subfamily; Region: SigBFG; TIGR02980
326424013141	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
326424013142	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
326424013143	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761
326424013144	Diacylglycerol kinase catalytic domain; Region: DAGK_cat; cl01255
326424013145	Glycerophosphoryl diester phosphodiesterase family; Region: GDPD; pfam03009
326424013146	Glycerophosphodiester phosphodiesterase domain as found in prokaryota and eukaryota, and similar proteins; Region: GDPD; cd08556
326424013147	active site
326424013148	metal binding site [ion binding]; metal-binding site
326424013149	catalytic site [active]
326424013150	Transcription factor WhiB; Region: Whib; pfam02467
326424013151	Signal transduction histidine kinase; Region: H_kinase_N; pfam12282
326424013152	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920
326424013153	Histidine kinase; Region: HisKA_2; cl06527
326424013154	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075
326424013155	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
326424013156	Aminotransferase class I and II; Region: Aminotran_1_2; pfam00155
326424013157	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
326424013158	catalytic residue [active]
326424013159	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
326424013160	biotin synthase; Validated; Region: PRK06256
326424013161	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
326424013162	FeS/SAM binding site; other site
326424013163	Biotin and Thiamin Synthesis associated domain; Region: BATS; cl06149
326424013164	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
326424013165	carboxyltransferase (CT) interaction site; other site
326424013166	biotinylation site [posttranslational modification]; other site
326424013167	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
326424013168	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
326424013169	NAD(P) binding site [chemical binding]; other site
326424013170	active site
326424013171	Putative zinc-finger; Region: zf-HC2; cl15806
326424013172	RNA polymerase sigma-70 factor, TIGR02947 family; Region: SigH_actino
326424013173	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
326424013174	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
326424013175	DNA binding residues [nucleotide binding]
326424013176	Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695
326424013177	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
326424013178	Amidase; Region: Amidase; cl11426
326424013179	Amidase; Region: Amidase; cl11426
326424013180	EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556
326424013181	3-phosphoshikimate 1-carboxyvinyltransferase; Region: aroA; TIGR01356
326424013182	hinge; other site
326424013183	active site
326424013184	ribosome small subunit-dependent GTPase A; Region: TIGR00157
326424013185	Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854
326424013186	GTPase/Zn-binding domain interface [polypeptide binding]; other site
326424013187	GTP/Mg2+ binding site [chemical binding]; other site
326424013188	G4 box; other site
326424013189	G1 box; other site
326424013190	Switch I region; other site
326424013191	G2 box; other site
326424013192	G3 box; other site
326424013193	Switch II region; other site
326424013194	Predominantly bacterial family of Mg++ dependend phosphatases, related to inositol monophosphatases. These enzymes may dephosphorylate fructose-1,6-bisphosphate, inositol monophospate, 3'-phosphoadenosine-5'-phosphate, or similar substrates; Region: Bacterial_IMPase_like_1; cd01641
326424013195	active site
326424013196	Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615
326424013197	catalytic site [active]
326424013198	active site
326424013199	acetoin dehydrogenase E2 subunit dihydrolipoyllysine-residue acetyltransferase; Provisional; Region: PRK14875
326424013200	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
326424013201	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
326424013202	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
326424013203	Escherichia coli NAD+-dependent gamma-aminobutyraldehyde dehydrogenase YdcW-like; Region: ALDH_ABALDH-YdcW; cd07092
326424013204	tetrameric interface [polypeptide binding]; other site
326424013205	NAD binding site [chemical binding]; other site
326424013206	catalytic residues [active]
326424013207	substrate binding site [chemical binding]; other site
326424013208	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
326424013209	FAD dependent oxidoreductase; Region: DAO; pfam01266
326424013210	Glutamate-1-semialdehyde aminotransferase [Coenzyme metabolism]; Region: HemL; COG0001
326424013211	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
326424013212	inhibitor-cofactor binding pocket; inhibition site
326424013213	pyridoxal 5'-phosphate binding site [chemical binding]; other site
326424013214	catalytic residue [active]
326424013215	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
326424013216	Helix-turn-helix domains; Region: HTH; cl00088
326424013217	Uncharacterized protein family (UPF0182); Region: UPF0182; pfam03699
326424013218	Uncharacterized conserved protein [Function unknown]; Region: COG1615; cl09133
326424013219	Predicted secreted protein containing a PDZ domain [Signal transduction mechanisms]; Region: SdrC; COG3480
326424013220	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
326424013221	Subunit ChlI of Mg-chelatase; Region: ChlI; cl12214
326424013222	MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cl00399
326424013223	Uncharacterized conserved protein (DUF2342); Region: DUF2342; cl02183
326424013224	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
326424013225	Sulfatase; Region: Sulfatase; cl10460
326424013226	Type I phosphodiesterase / nucleotide pyrophosphatase; Region: Phosphodiest; pfam01663
326424013227	Transcription factor WhiB; Region: Whib; pfam02467
326424013228	Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210
326424013229	Family description; Region: UvrD_C_2; cl15862
326424013230	HRDC domain; Region: HRDC; cl02578
326424013231	NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976
326424013232	catalytic residues [active]
326424013233	ANTAR domain; Region: ANTAR; cl04297
326424013234	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
326424013235	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
326424013236	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
326424013237	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
326424013238	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
326424013239	Helix-turn-helix domains; Region: HTH; cl00088
326424013240	Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490
326424013241	Helix-Turn-Helix DNA binding domain of the BmrR transcription regulator; Region: HTH_BmrR; cd01107
326424013242	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
326424013243	DNA binding residues [nucleotide binding]
326424013244	drug binding residues [chemical binding]; other site
326424013245	Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cl00120
326424013246	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
326424013247	Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210
326424013248	UvrD-like helicase C-terminal domain; Region: UvrD_C; pfam13361
326424013249	CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641
326424013250	UvrD/REP helicase N-terminal domain; Region: UvrD-helicase; pfam00580
326424013251	ATP-dependent exoDNAse (exonuclease V) beta subunit (contains helicase and exonuclease domains) [DNA replication, recombination, and repair]; Region: RecB; COG1074
326424013252	UvrD-like helicase C-terminal domain; Region: UvrD_C; pfam13361
326424013253	CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641
326424013254	The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445
326424013255	DNA binding site [nucleotide binding]
326424013256	active site
326424013257	molybdopterin biosynthesis-like protein MoeZ; Validated; Region: PRK07878
326424013258	ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757
326424013259	ATP binding site [chemical binding]; other site
326424013260	substrate interface [chemical binding]; other site
326424013261	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
326424013262	active site residue [active]
326424013263	CsbD-like; Region: CsbD; cl15799
326424013264	Ku protein, prokaryotic; Region: Ku_bact; TIGR02772
326424013265	Ku-core domain, Ku-like subfamily; composed of prokaryotic homologs of the eukaryotic DNA binding protein Ku. The alignment includes the core domain shared by the prokaryotic YkoV-like proteins and the eukaryotic Ku70 and Ku80. The prokaryotic Ku...; Region: KU_like; cd00789
326424013266	putative DNA binding site [nucleotide binding]; other site
326424013267	putative homodimer interface [polypeptide binding]; other site
326424013268	MtLigD_Pol_like: Polymerase (Pol) domain of bacterial LigD proteins similar to Mycobacterium tuberculosis (Mt)LigD. The LigD Pol domain belongs to the archaeal/eukaryal primase (AEP) superfamily. In prokaryotes, LigD along with Ku is required for...; Region: MtLigD_Pol_like; cd04863
326424013269	nucleotide binding site [chemical binding]; other site
326424013270	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
326424013271	Helix-turn-helix domains; Region: HTH; cl00088
326424013272	Protein of unknown function (DUF3107); Region: DUF3107; pfam11305
326424013273	Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657
326424013274	dinuclear metal binding motif [ion binding]; other site
326424013275	DEAD-like helicases superfamily; Region: DEXDc; smart00487
326424013276	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
326424013277	ATP binding site [chemical binding]; other site
326424013278	Mg++ binding site [ion binding]; other site
326424013279	motif III; other site
326424013280	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
326424013281	nucleotide binding region [chemical binding]; other site
326424013282	ATP-binding site [chemical binding]; other site
326424013283	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
326424013284	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
326424013285	P-loop; other site
326424013286	Magnesium ion binding site [ion binding]; other site
326424013287	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
326424013288	Magnesium ion binding site [ion binding]; other site
326424013289	Domain of unknown function DUF21; Region: DUF21; pfam01595
326424013290	Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253
326424013291	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
326424013292	Transporter associated domain; Region: CorC_HlyC; cl08393
326424013293	Domain of unknown function DUF21; Region: DUF21; pfam01595
326424013294	FOG: CBS domain [General function prediction only]; Region: COG0517
326424013295	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
326424013296	Antibiotic biosynthesis monooxygenase; Region: ABM; cl10022
326424013297	hypothetical protein; Provisional; Region: PRK08912
326424013298	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
326424013299	pyridoxal 5'-phosphate binding site [chemical binding]; other site
326424013300	homodimer interface [polypeptide binding]; other site
326424013301	catalytic residue [active]
326424013302	CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641
326424013303	CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641
326424013304	Chorismate mutase type II; Region: CM_2; cl00693
326424013305	Protein of unknown function (DUF1003); Region: DUF1003; cl01831
326424013306	MgtE intracellular N domain; Region: MgtE_N; cl15244
326424013307	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE.  MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606
326424013308	Pyruvate kinase (PK):  Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl09155
326424013309	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
326424013310	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
326424013311	active site
326424013312	3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084
326424013313	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
326424013314	Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974
326424013315	Uncharacterized proteins involved in stress response, homologs of TerZ and putative cAMP-binding protein CABP1 [Signal transduction mechanisms]; Region: TerZ; COG2310
326424013316	Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974
326424013317	putative metal binding site [ion binding]; other site
326424013318	Suppressor of fused protein (SUFU); Region: SUFU; pfam05076
326424013319	FkbR2 is a Streptomyces hygroscopicus protein with a hot dog fold that belongs to a conserved family of proteins found in prokaryotes and archaea but not in eukaryotes. FkbR2  has sequence similarity to (R)-specific enoyl-CoA hydratase, the peroxisomal...; Region: FkbR2; cd03451
326424013320	putative active site [active]
326424013321	putative catalytic site [active]
326424013322	PhoD-like phosphatase; Region: PhoD; pfam09423
326424013323	Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389
326424013324	putative active site [active]
326424013325	putative metal binding site [ion binding]; other site
326424013326	Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389
326424013327	Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843
326424013328	Ubiquinol oxidase subunit I.  Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane.  It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662
326424013329	D-pathway; other site
326424013330	Putative ubiquinol binding site [chemical binding]; other site
326424013331	Low-spin heme (heme b) binding site [chemical binding]; other site
326424013332	Putative water exit pathway; other site
326424013333	Binuclear center (heme o3/CuB) [ion binding]; other site
326424013334	K-pathway; other site
326424013335	Putative proton exit pathway; other site
326424013336	Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597
326424013337	4-aminobutyrate aminotransferase; Provisional; Region: PRK06058
326424013338	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
326424013339	inhibitor-cofactor binding pocket; inhibition site
326424013340	pyridoxal 5'-phosphate binding site [chemical binding]; other site
326424013341	catalytic residue [active]
326424013342	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
326424013343	Aldehyde dehydrogenase family 21A1-like; Region: ALDH_F21_RNP123; cd07147
326424013344	NAD(P) binding site [chemical binding]; other site
326424013345	catalytic residues [active]
326424013346	Predicted metal-dependent phosphoesterases (PHP family) [General function prediction only]; Region: COG0613
326424013347	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
326424013348	Helix-turn-helix domains; Region: HTH; cl00088
326424013349	Domain of unknown function DUF59; Region: DUF59; cl00941
326424013350	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Mrp; COG0489
326424013351	MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037
326424013352	mttA/Hcf106 family; Region: MttA_Hcf106; cl00788
326424013353	Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149
326424013354	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
326424013355	Putative zinc-finger; Region: zf-HC2; cl15806
326424013356	RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
326424013357	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
326424013358	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761
326424013359	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
326424013360	S-adenosylmethionine binding site [chemical binding]; other site
326424013361	Cytosol aminopeptidase family, N-terminal and catalytic domains.  Family M17 contains zinc- and manganese-dependent exopeptidases ( EC  3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433
326424013362	interface (dimer of trimers) [polypeptide binding]; other site
326424013363	Substrate-binding/catalytic site; other site
326424013364	Zn-binding sites [ion binding]; other site
326424013365	Protein of unknown function (DUF3117); Region: DUF3117; pfam11314
326424013366	DivIVA domain; Region: DivI1A_domain; TIGR03544
326424013367	dihydropteroate synthase; Region: DHPS; TIGR01496
326424013368	DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739
326424013369	substrate binding pocket [chemical binding]; other site
326424013370	dimer interface [polypeptide binding]; other site
326424013371	inhibitor binding site; inhibition site
326424013372	Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695
326424013373	Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695
326424013374	O-Glycosyl hydrolase family 30; Region: Glyco_hydro_30; pfam02055
326424013375	O-Glycosyl hydrolase [Cell envelope biogenesis, outer membrane]; Region: COG5520
326424013376	SGNH_hydrolase subfamily, similar to Ruminococcus flavefaciens XynB. Most likely a secreted hydrolase with xylanase activity. SGNH hydrolases are a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from...; Region: XynB_like; cd01833
326424013377	active site
326424013378	catalytic triad [active]
326424013379	oxyanion hole [active]
326424013380	Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes; Region: FA58C; cl12042
326424013381	sugar binding site [chemical binding]; other site
326424013382	OpgC protein; Region: OpgC_C; cl00792
326424013383	CESA_like is  the cellulose synthase superfamily; Region: CESA_like; cd06423
326424013384	DXD motif; other site
326424013385	exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025
326424013386	Bacterial sugar transferase; Region: Bac_transf; cl00939
326424013387	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
326424013388	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
326424013389	2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy; cl15773
326424013390	FAD dependent oxidoreductase; Region: FAD_oxidored; pfam12831
326424013391	Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; cl09156
326424013392	Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244
326424013393	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
326424013394	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
326424013395	active site
326424013396	DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179
326424013397	Ligand binding site; other site
326424013398	Putative Catalytic site; other site
326424013399	DXD motif; other site
326424013400	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
326424013401	glycosyl hydrolase family 16; Region: Glyco_hydrolase_16; cd00413
326424013402	active site
326424013403	catalytic residues [active]
326424013404	Acetylornithine deacetylase/Succinyl-diaminopimelate desuccinylase and related deacylases [Amino acid transport and metabolism]; Region: ArgE; COG0624
326424013405	M20 Peptidase actinobacterial DapE encoded N-succinyl-L,L-diaminopimelic acid desuccinylase; Region: M20_DapE_actinobac; cd05647
326424013406	metal binding site [ion binding]; metal-binding site
326424013407	putative dimer interface [polypeptide binding]; other site
326424013408	2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase; Region: dapD; TIGR00965
326424013409	Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160
326424013410	succinyldiaminopimelate transaminase; Region: DapC_actino; TIGR03539
326424013411	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
326424013412	pyridoxal 5'-phosphate binding site [chemical binding]; other site
326424013413	homodimer interface [polypeptide binding]; other site
326424013414	catalytic residue [active]
326424013415	Spumavirus gag protein; Region: Gag_spuma; pfam03276
326424013416	Ferredoxin [Energy production and conversion]; Region: COG1146
326424013417	4Fe-4S binding domain; Region: Fer4; cl02805
326424013418	Transglutaminase-like superfamily; Region: Transglut_core2; pfam13369
326424013419	Flavin Reductases; Region: FlaRed; cl00801
326424013420	Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149
326424013421	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
326424013422	protein binding site [polypeptide binding]; other site
326424013423	GlcNAc-PI de-N-acetylase; Region: PIG-L; cl00929
326424013424	Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891
326424013425	GTP-binding protein TypA/BipA; Region: TypA_BipA; TIGR01394
326424013426	G1 box; other site
326424013427	putative GEF interaction site [polypeptide binding]; other site
326424013428	GTP/Mg2+ binding site [chemical binding]; other site
326424013429	Switch I region; other site
326424013430	G2 box; other site
326424013431	G3 box; other site
326424013432	Switch II region; other site
326424013433	G4 box; other site
326424013434	G5 box; other site
326424013435	BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu.  BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691
326424013436	BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants.  BipA is a highly...; Region: BipA_TypA_C; cd03710
326424013437	The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425
326424013438	active site
326424013439	8-oxo-dGMP binding site [chemical binding]; other site
326424013440	nudix motif; other site
326424013441	metal binding site [ion binding]; metal-binding site
326424013442	PCD_DCoH: The bifunctional protein pterin-4alpha-carbinolamine dehydratase (PCD), also known as DCoH  (dimerization cofactor of hepatocyte nuclear factor-1), is both a transcription activator and a metabolic enzyme.  DCoH stimulates gene expression by...; Region: PCD_DCoH; cl00942
326424013443	DCoH dimer interaction site [polypeptide binding]; other site
326424013444	substrate binding site [chemical binding]; other site
326424013445	3-methyladenine DNA glycosylase/8-oxoguanine DNA glycosylase [DNA replication, recombination, and repair]; Region: AlkA; COG0122
326424013446	Protein of unknown function (DUF952); Region: DUF952; cl01393
326424013447	GTP-binding protein YchF; Reviewed; Region: PRK09601
326424013448	YchF GTPase; Region: YchF; cd01900
326424013449	G1 box; other site
326424013450	GTP/Mg2+ binding site [chemical binding]; other site
326424013451	Switch I region; other site
326424013452	G2 box; other site
326424013453	Switch II region; other site
326424013454	G3 box; other site
326424013455	G4 box; other site
326424013456	G5 box; other site
326424013457	The TGS domain, named after the ThrRS, GTPase, and SpoT/RelA proteins where it occurs, is structurally similar to ubiquitin. TGS is a small domain of about 50 amino acid residues with a predominantly beta-sheet structure. There is no direct information...; Region: TGS; cl15768
326424013458	RmuC family; Region: RmuC; pfam02646
326424013459	Putative catalytic NodB homology domain of PgaB, IcaB, and similar proteins which consist of a deformed (beta/alpha)8 barrel fold with 5- or 6-strands; Region: CE4_NodB_like_5s_6s; cd10918
326424013460	putative active site [active]
326424013461	putative metal binding site [ion binding]; other site
326424013462	Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; cl01132
326424013463	Bacterial fructose-1,6-bisphosphatase, glpX-encoded. A dimeric enzyme dependent on Mg(2+). glpX-encoded FPBase (FBPase class II) differs from other members of the inositol-phosphatase superfamily by permutation of secondary structure elements. The core...; Region: FBPase_glpX; cd01516
326424013464	putative active site [active]
326424013465	Protein of unknown function (DUF4245); Region: DUF4245; pfam14030
326424013466	Exonuclease VII small subunit; Region: Exonuc_VII_S; cl00750
326424013467	exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286
326424013468	ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489
326424013469	generic binding surface I; other site
326424013470	generic binding surface II; other site
326424013471	LytB protein; Region: LYTB; cl00507
326424013472	(E)-4-hydroxy-3-methyl-but-2-enyl pyrophosphate reductase (IPP and DMAPP forming); Region: ispH_lytB; TIGR00216
326424013473	fumarate hydratase; Reviewed; Region: fumC; PRK00485
326424013474	aspartase (L-aspartate ammonia-lyase) and fumarase class II enzymes; Region: Aspartase_like; cd01596
326424013475	active sites [active]
326424013476	tetramer interface [polypeptide binding]; other site
326424013477	soluble pyridine nucleotide transhydrogenase; Provisional; Region: PRK05249
326424013478	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
326424013479	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
326424013480	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
326424013481	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009
326424013482	ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192
326424013483	substrate binding site [chemical binding]; other site
326424013484	ATP binding site [chemical binding]; other site
326424013485	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
326424013486	active site
326424013487	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
326424013488	Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; cl03161
326424013489	Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738
326424013490	Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738
326424013491	Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080
326424013492	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cl00159
326424013493	[2Fe-2S] binding domain; Region: Fer2_2; pfam01799
326424013494	xanthine dehydrogenase subunit XdhA; Provisional; Region: PRK09970
326424013495	Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; cl03161
326424013496	Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738
326424013497	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319
326424013498	CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; cl08390
326424013499	Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cl00214
326424013500	intersubunit interface [polypeptide binding]; other site
326424013501	active site
326424013502	Zn2+ binding site [ion binding]; other site
326424013503	Isochorismatase family; Region: Isochorismatase; pfam00857
326424013504	Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cl00220
326424013505	catalytic triad [active]
326424013506	conserved cis-peptide bond; other site
326424013507	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587
326424013508	active site
326424013509	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
326424013510	metal binding site [ion binding]; metal-binding site
326424013511	classical (c) SDRs; Region: SDR_c; cd05233
326424013512	NAD(P) binding site [chemical binding]; other site
326424013513	active site
326424013514	Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938
326424013515	iron-sulfur cluster [ion binding]; other site
326424013516	[2Fe-2S] cluster binding site [ion binding]; other site
326424013517	START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643
326424013518	hydrophobic ligand binding site; other site
326424013519	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
326424013520	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587
326424013521	active site
326424013522	metal binding site [ion binding]; metal-binding site
326424013523	Leucyl aminopeptidase (aminopeptidase T) [Amino acid transport and metabolism]; Region: AmpS; COG2309
326424013524	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421
326424013525	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
326424013526	Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141
326424013527	The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature; Region: BAR; cl12013
326424013528	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
326424013529	DNA-binding site [nucleotide binding]; DNA binding site
326424013530	phosphonate utilization associated transcriptional regulator; Region: phnR_burk; TIGR03338
326424013531	FCD domain; Region: FCD; cl11656
326424013532	Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154
326424013533	Amidase; Region: Amidase; cl11426
326424013534	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_2; cd07253
326424013535	dimer interface [polypeptide binding]; other site
326424013536	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
326424013537	metal binding site [ion binding]; metal-binding site
326424013538	Transcriptional regulators [Transcription]; Region: PhnF; COG2188
326424013539	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
326424013540	DNA-binding site [nucleotide binding]; DNA binding site
326424013541	UTRA domain; Region: UTRA; cl01230
326424013542	drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710
326424013543	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
326424013544	putative substrate translocation pore; other site
326424013545	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
326424013546	Helix-turn-helix domains; Region: HTH; cl00088
326424013547	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124
326424013548	The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE).  The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257
326424013549	Walker A/P-loop; other site
326424013550	ATP binding site [chemical binding]; other site
326424013551	Q-loop/lid; other site
326424013552	ABC transporter signature motif; other site
326424013553	Walker B; other site
326424013554	D-loop; other site
326424013555	H-loop/switch region; other site
326424013556	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124
326424013557	The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE).  The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257
326424013558	Walker A/P-loop; other site
326424013559	ATP binding site [chemical binding]; other site
326424013560	Q-loop/lid; other site
326424013561	ABC transporter signature motif; other site
326424013562	Walker B; other site
326424013563	D-loop; other site
326424013564	H-loop/switch region; other site
326424013565	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
326424013566	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
326424013567	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427
326424013568	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173
326424013569	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
326424013570	dimer interface [polypeptide binding]; other site
326424013571	ABC-ATPase subunit interface; other site
326424013572	putative PBP binding loops; other site
326424013573	The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_7; cd08512
326424013574	Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496
326424013575	nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095
326424013576	active site
326424013577	FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860
326424013578	non-prolyl cis peptide bond; other site
326424013579	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
326424013580	nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095
326424013581	active site
326424013582	FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860
326424013583	non-prolyl cis peptide bond; other site
326424013584	Flavin Reductases; Region: FlaRed; cl00801
326424013585	Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446
326424013586	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
326424013587	Catalytic domain of Protein Kinases; Region: PKc; cd00180
326424013588	active site
326424013589	ATP binding site [chemical binding]; other site
326424013590	substrate binding site [chemical binding]; other site
326424013591	activation loop (A-loop); other site
326424013592	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447
326424013593	nudix motif; other site
326424013594	adenylate kinases; Region: adk; TIGR01351
326424013595	Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428
326424013596	AMP-binding site [chemical binding]; other site
326424013597	ATP-AMP (Ap5A)-binding site [chemical binding]; other site
326424013598	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
326424013599	active site
326424013600	Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; cl00986
326424013601	UMP phosphatase; Provisional; Region: PRK10444
326424013602	Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391
326424013603	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
326424013604	Peptide methionine sulfoxide reductase; Region: PMSR; cl00366
326424013605	NYN ribonuclease and ATPase of PhoH family domains [General    function prediction only]; Region: COG1875
326424013606	PIN domain of bacterial Smg6-like homologs with PhoH-like ATPase domains; Region: PIN_PhoHL-ATPase; cd09883
326424013607	putative active site [active]
326424013608	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
326424013609	Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_GTP; cd00819
326424013610	Phosphoenolpyruvate carboxykinase; Region: PEPCK; pfam00821
326424013611	active site
326424013612	substrate-binding site [chemical binding]; other site
326424013613	metal-binding site [ion binding]
326424013614	GTP binding site [chemical binding]; other site
326424013615	Haemolysin-III related; Region: HlyIII; cl03831
326424013616	Highly conserved protein containing a thioredoxin domain [Posttranslational modification, protein turnover, chaperones]; Region: COG1331
326424013617	TRX domain, SSP411 protein family; members of this family are highly conserved proteins present in eukaryotes, bacteria and archaea, about 600-800 amino acids in length, which contain a TRX domain with a redox active CXXC motif. The human/rat protein; Region: SSP411; cd02955
326424013618	catalytic residues [active]
326424013619	valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729
326424013620	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
326424013621	active site
326424013622	HIGH motif; other site
326424013623	nucleotide binding site [chemical binding]; other site
326424013624	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
326424013625	Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603
326424013626	Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603
326424013627	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
326424013628	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
326424013629	active site
326424013630	KMSKS motif; other site
326424013631	Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958
326424013632	tRNA binding surface [nucleotide binding]; other site
326424013633	GlcNAc-PI de-N-acetylase; Region: PIG-L; cl00929
326424013634	transcription elongation factor GreA; Reviewed; Region: greA; PRK00226
326424013635	Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449
326424013636	Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272
326424013637	Mg-chelatase subunit ChlI [Coenzyme metabolism]; Region: ChlI; COG1239
326424013638	Uncharacterized protein with a von Willebrand factor type A (vWA) domain [General function prediction only]; Region: COG4867
326424013639	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198
326424013640	metal ion-dependent adhesion site (MIDAS); other site
326424013641	Domain of unknown function (DUF3291); Region: DUF3291; pfam11695
326424013642	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
326424013643	MBOAT, membrane-bound O-acyltransferase family; Region: MBOAT; cl00738
326424013644	SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053
326424013645	active site
326424013646	catalytic triad [active]
326424013647	oxyanion hole [active]
326424013648	Domain of unknown function (DUF4287); Region: DUF4287; pfam14117
326424013649	Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381
326424013650	BAX inhibitor (BI)-1/YccA-like protein family; Region: BI-1-like; cl00473
326424013651	NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252
326424013652	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
326424013653	Uracil-DNA glycosylases (UDG) and related enzymes; Region: UDG_like; cl00483
326424013654	ligand binding site [chemical binding]; other site
326424013655	active site
326424013656	Ppx/GppA phosphatase family; Region: Ppx-GppA; cl15449
326424013657	Ppx/GppA phosphatase family; Region: Ppx-GppA; cl15449
326424013658	Protein of unknown function (DUF501); Region: DUF501; cl00652
326424013659	Septum formation initiator; Region: DivIC; cl11433
326424013660	enolase; Provisional; Region: eno; PRK00077
326424013661	Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313
326424013662	dimer interface [polypeptide binding]; other site
326424013663	metal binding site [ion binding]; metal-binding site
326424013664	substrate binding pocket [chemical binding]; other site
326424013665	Signal peptide peptidase A (SppA) 67K type, a serine protease, has catalytic Ser-Lys dyad; Region: S49_SppA_67K_type; cd07018
326424013666	tandem repeat interface [polypeptide binding]; other site
326424013667	oligomer interface [polypeptide binding]; other site
326424013668	active site residues [active]
326424013669	Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023
326424013670	tandem repeat interface [polypeptide binding]; other site
326424013671	oligomer interface [polypeptide binding]; other site
326424013672	active site residues [active]
326424013673	nucleoside triphosphate pyrophosphohydrolase; Reviewed; Region: PRK12334
326424013674	nucleoside triphosphate pyrophosphohydrolase; Reviewed; Region: PRK12334
326424013675	MazG nucleotide pyrophosphohydrolase domain; Region: MazG; cl00345
326424013676	Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197
326424013677	CarD-like/TRCF domain; Region: CarD_CdnL_TRCF; cl00588
326424013678	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
326424013679	ATP binding site [chemical binding]; other site
326424013680	putative Mg++ binding site [ion binding]; other site
326424013681	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
326424013682	nucleotide binding region [chemical binding]; other site
326424013683	ATP-binding site [chemical binding]; other site
326424013684	TRCF domain; Region: TRCF; cl04088
326424013685	Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789
326424013686	Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600
326424013687	DNA binding residues [nucleotide binding]
326424013688	Glycosyl hydrolase family 26; Region: Glyco_hydro_26; cl09200
326424013689	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
326424013690	active site
326424013691	Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876
326424013692	Domain of unknown function (DUF2172); Region: DUF2172; pfam09940
326424013693	metal binding site [ion binding]; metal-binding site
326424013694	CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516
326424013695	substrate binding site; other site
326424013696	dimer interface; other site
326424013697	Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221
326424013698	classical (c) SDRs; Region: SDR_c; cd05233
326424013699	NAD(P) binding site [chemical binding]; other site
326424013700	active site
326424013701	Glycosyl hydrolase family 26; Region: Glyco_hydro_26; cl09200
326424013702	O-methyltransferase; Region: Methyltransf_3; pfam01596
326424013703	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
326424013704	MatE; Region: MatE; cl10513
326424013705	Putative zinc binding domain; Region: Methyltransf_13; pfam08421
326424013706	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
326424013707	C-methyltransferase C-terminal domain; Region: Methyltransf_14; pfam08484
326424013708	Cupin domain; Region: Cupin_2; cl09118
326424013709	NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370
326424013710	extended (e) SDRs; Region: SDR_e; cd08946
326424013711	NAD(P) binding site [chemical binding]; other site
326424013712	active site
326424013713	substrate binding site [chemical binding]; other site
326424013714	serine O-acetyltransferase; Region: cysE; TIGR01172
326424013715	Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160
326424013716	Phosphopantetheine attachment site; Region: PP-binding; cl09936
326424013717	Predicted enzyme involved in methoxymalonyl-ACP biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FkbH; COG3882
326424013718	Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391
326424013719	Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cd00306
326424013720	active site
326424013721	catalytic residues [active]
326424013722	tyrosyl-tRNA synthetase; Validated; Region: PRK05912
326424013723	catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805
326424013724	active site
326424013725	HIGH motif; other site
326424013726	dimer interface [polypeptide binding]; other site
326424013727	KMSKS motif; other site
326424013728	Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186
326424013729	Probable Catalytic site; other site
326424013730	metal-binding site
326424013731	CESA_like_1 is a member of the cellulose synthase (CESA) superfamily; Region: CESA_like_1; cd06439
326424013732	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
326424013733	DXD motif; other site
326424013734	sugar transferase, PEP-CTERM/EpsH1 system associated; Region: stp1; TIGR03087
326424013735	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
326424013736	Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462
326424013737	putative active site [active]
326424013738	catalytic residue [active]
326424013739	50S ribosomal protein L25/general stress protein Ctc; Reviewed; Region: PRK05618
326424013740	Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495
326424013741	5S rRNA interface [nucleotide binding]; other site
326424013742	CTC domain interface [polypeptide binding]; other site
326424013743	L16 interface [polypeptide binding]; other site
326424013744	Asp23 family; Region: Asp23; cl00574
326424013745	DnaJ_C chaperone protein; Provisional; Region: PTZ00037
326424013746	Asp23 family; Region: Asp23; cl00574
326424013747	4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: PRK03188
326424013748	4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: PRK03188
326424013749	ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488
326424013750	ABCF_EF-3  Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth.  EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221
326424013751	ABC transporter; Region: ABC_tran_2; pfam12848
326424013752	ABCF_EF-3  Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth.  EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221
326424013753	The Delta9 Fatty Acid Desaturase (Delta9-FADS)-like CD includes the delta-9 and delta-11 acyl CoA desaturases found in various eukaryotes including vertebrates, insects, higher plants, and fungi. The delta-9 acyl-lipid desaturases are found in a wide...; Region: Delta9-FADS-like; cd03505
326424013754	Di-iron ligands [ion binding]; other site
326424013755	The Delta9 Fatty Acid Desaturase (Delta9-FADS)-like CD includes the delta-9 and delta-11 acyl CoA desaturases found in various eukaryotes including vertebrates, insects, higher plants, and fungi. The delta-9 acyl-lipid desaturases are found in a wide...; Region: Delta9-FADS-like; cd03505
326424013756	bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14352
326424013757	N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540
326424013758	Substrate binding site; other site
326424013759	Mg++ binding site; other site
326424013760	N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353
326424013761	active site
326424013762	substrate binding site [chemical binding]; other site
326424013763	CoA binding site [chemical binding]; other site
326424013764	N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793
326424013765	ribose-phosphate pyrophosphokinase; Provisional; Region: PRK03092
326424013766	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
326424013767	active site
326424013768	tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282
326424013769	catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806
326424013770	active site
326424013771	HIGH motif; other site
326424013772	dimer interface [polypeptide binding]; other site
326424013773	KMSKS motif; other site
326424013774	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
326424013775	TatD like proteins;  E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310
326424013776	active site
326424013777	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
326424013778	YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cl00630
326424013779	putative active site [active]
326424013780	Predicted methyltransferases [General function prediction only]; Region: COG0313
326424013781	Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl15769
326424013782	Dolichyl-phosphate-mannose--protein O-mannosyl transferase [Posttranslational modification, protein turnover, chaperones]; Region: PMT1; COG1928
326424013783	Glucoamylase and related glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: SGA1; COG3387
326424013784	Glycosyl hydrolases family 15; Region: Glyco_hydro_15; pfam00723
326424013785	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
326424013786	phosphopeptide binding site; other site
326424013787	Domain of unknown function (DUF305); Region: DUF305; cl15795
326424013788	Sulfate transporter family; Region: Sulfate_transp; cl15842
326424013789	Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659
326424013790	Sulfate transporter family; Region: Sulfate_transp; cl15842
326424013791	Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042
326424013792	Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647
326424013793	active site
326424013794	YceI-like domain; Region: YceI; cl01001
326424013795	Xanthine/uracil/vitamin C permease [Nucleotide transport and    metabolism]; Region: COG2252
326424013796	Isochorismatase family; Region: Isochorismatase; pfam00857
326424013797	Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431
326424013798	catalytic triad [active]
326424013799	conserved cis-peptide bond; other site
326424013800	The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509
326424013801	Acyl-CoA thioesterase [Lipid metabolism]; Region: TesB; COG1946
326424013802	active site 2 [active]
326424013803	The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509
326424013804	active site 2 [active]
326424013805	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
326424013806	putative substrate translocation pore; other site
326424013807	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
326424013808	Helix-turn-helix domains; Region: HTH; cl00088
326424013809	Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909
326424013810	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
326424013811	active site
326424013812	ATP binding site [chemical binding]; other site
326424013813	substrate binding site [chemical binding]; other site
326424013814	activation loop (A-loop); other site
326424013815	Predicted Rossmann fold nucleotide-binding protein involved in DNA uptake [DNA replication, recombination, and repair / Intracellular trafficking and secretion]; Region: Smf; COG0758
326424013816	Protein of unknown function (DUF1006); Region: DUF1006; cl15826
326424013817	Possible enoyl reductase; Region: MDR_enoyl_red; cd08244
326424013818	NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604
326424013819	putative NAD(P) binding site [chemical binding]; other site
326424013820	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447
326424013821	nudix motif; other site
326424013822	Helix-Turn-Helix DNA binding domain of truncated MerR-like proteins; Region: HTH_MerR-trunc; cd04762
326424013823	DNA binding residues [nucleotide binding]
326424013824	TOBE domain; Region: TOBE_2; cl01440
326424013825	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427
326424013826	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
326424013827	Q-loop/lid; other site
326424013828	ABC transporter signature motif; other site
326424013829	Walker B; other site
326424013830	D-loop; other site
326424013831	H-loop/switch region; other site
326424013832	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_9; cd04622
326424013833	Domain of unknown function (DUF1918); Region: DUF1918; pfam08940
326424013834	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cl00309
326424013835	3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565
326424013836	classical (c) SDRs; Region: SDR_c; cd05233
326424013837	NAD(P) binding site [chemical binding]; other site
326424013838	active site
326424013839	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761
326424013840	sporadically distributed protein, TIGR04141 family; Region: TIGR04141
326424013841	Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210
326424013842	Family description; Region: UvrD_C_2; cl15862
326424013843	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
326424013844	helicase/secretion neighborhood putative DEAH-box helicase; Region: DECH_helic; TIGR03817
326424013845	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
326424013846	ATP-binding site [chemical binding]; other site
326424013847	Domain of unknown function (DUF1998); Region: DUF1998; pfam09369
326424013848	Superfamily II DNA/RNA helicases, SNF2 family [Transcription / DNA replication, recombination, and repair]; Region: HepA; COG0553
326424013849	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
326424013850	ATP binding site [chemical binding]; other site
326424013851	putative Mg++ binding site [ion binding]; other site
326424013852	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
326424013853	conjugative relaxase domain, TrwC/TraI family; Region: relax_trwC; TIGR02686
326424013854	Ti-type conjugative transfer relaxase TraA; Region: TraA_Ti; TIGR02768
326424013855	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
326424013856	Homeobox associated leucine zipper; Region: HALZ; cl02577
326424013857	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
326424013858	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200
326424013859	FOG: WD40 repeat [General function prediction only]; Region: COG2319
326424013860	structural tetrad; other site
326424013861	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200
326424013862	structural tetrad; other site
326424013863	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567
326424013864	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567
326424013865	SpaB C-terminal domain; Region: SpaB_C; cl14828
326424013866	Lanthionine synthetase C-like protein; Region: LANC_like; pfam05147
326424013867	LanC is the cyclase enzyme of the lanthionine synthetase. Lanthinoine is a lantibiotic, a unique class of peptide antibiotics. They are ribosomally synthesized as precursor peptides and then post-translationally modified to contain thioether cross-links...; Region: LanC; cd04793
326424013868	active site
326424013869	zinc binding site [ion binding]; other site
326424013870	Lantibiotic dehydratase, N terminus; Region: Lant_dehyd_N; pfam04737
326424013871	Lantibiotic dehydratase, C terminus; Region: Lant_dehyd_C; pfam04738
326424013872	SpaB C-terminal domain; Region: SpaB_C; cl14828
326424013873	Protein-L-isoaspartate carboxylmethyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: Pcm; COG2518
326424013874	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
326424013875	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
326424013876	S-adenosylmethionine binding site [chemical binding]; other site
326424013877	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761
326424013878	Domain of unknown function (DUF397); Region: DUF397; pfam04149
326424013879	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
326424013880	non-specific DNA binding site [nucleotide binding]; other site
326424013881	salt bridge; other site
326424013882	sequence-specific DNA binding site [nucleotide binding]; other site
326424013883	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075
326424013884	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447
326424013885	nudix motif; other site
326424013886	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
326424013887	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
326424013888	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
326424013889	DNA binding site [nucleotide binding]
326424013890	active site
326424013891	Int/Topo IB signature motif; other site
326424013892	Uncharacterized membrane-anchored protein conserved in bacteria [Function unknown]; Region: COG4705
326424013893	Repeat of Unknown Function (DUF347); Region: DUF347; pfam03988
326424013894	Repeat of Unknown Function (DUF347); Region: DUF347; pfam03988
326424013895	Repeat of Unknown Function (DUF347); Region: DUF347; pfam03988
326424013896	Repeat of Unknown Function (DUF347); Region: DUF347; pfam03988
326424013897	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
326424013898	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
326424013899	active site
326424013900	phosphorylation site [posttranslational modification]
326424013901	intermolecular recognition site; other site
326424013902	dimerization interface [polypeptide binding]; other site
326424013903	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
326424013904	DNA binding site [nucleotide binding]
326424013905	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
326424013906	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054
326424013907	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
326424013908	dimer interface [polypeptide binding]; other site
326424013909	phosphorylation site [posttranslational modification]
326424013910	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
326424013911	ATP binding site [chemical binding]; other site
326424013912	Mg2+ binding site [ion binding]; other site
326424013913	G-X-G motif; other site
326424013914	Mycobacterium tuberculosis succinate-semialdehyde dehydrogenase 1-like; Region: ALDH_SSADH1_GabD1; cd07100
326424013915	NAD(P) binding site [chemical binding]; other site
326424013916	catalytic residues [active]
326424013917	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
326424013918	coenzyme F420-dependent oxidoreductase, NP1902A family; Region: F420_NP1902A; TIGR04024
326424013919	Uncharacterized conserved protein (DUF2267); Region: DUF2267; cl02314
326424013920	Uncharacterized conserved protein (DUF2267); Region: DUF2267; cl02314
326424013921	Antibiotic biosynthesis monooxygenase; Region: ABM; cl10022
326424013922	Helix-turn-helix domains; Region: HTH; cl00088
326424013923	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
326424013924	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009
326424013925	Pantoate-beta-alanine ligase; Region: PanC; cd00560
326424013926	pantoate--beta-alanine ligase; Region: panC; TIGR00018
326424013927	active site
326424013928	ATP-binding site [chemical binding]; other site
326424013929	pantoate-binding site; other site
326424013930	HXXH motif; other site
326424013931	Streptomyces putative phosphonoformaldehyde dehydrogenase PhpJ-like; Region: ALDH_PhpJ; cd07146
326424013932	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
326424013933	NAD(P) binding site [chemical binding]; other site
326424013934	catalytic residues [active]
326424013935	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
326424013936	S-adenosylmethionine binding site [chemical binding]; other site
326424013937	H+ Antiporter protein; Region: 2A0121; TIGR00900
326424013938	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
326424013939	Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714
326424013940	Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377
326424013941	tetramer interface [polypeptide binding]; other site
326424013942	active site
326424013943	Mg2+/Mn2+ binding site [ion binding]; other site
326424013944	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
326424013945	phosphonopyruvate decarboxylase; Region: Ppyr-DeCO2ase; TIGR03297
326424013946	PYR/PP interface [polypeptide binding]; other site
326424013947	dimer interface [polypeptide binding]; other site
326424013948	TPP binding site [chemical binding]; other site
326424013949	Thiamine pyrophosphate (TPP) family, PpyrDC subfamily, TPP-binding module; composed of proteins similar to phosphonopyruvate decarboxylase (PpyrDC) proteins. PpyrDC is a homotrimeric enzyme which functions in the biosynthesis of C-P compounds such as...; Region: TPP_PpyrDC; cd03371
326424013950	TPP-binding site; other site
326424013951	Hydroxyethylphosphoate dehydrogenase (HEPD) catalyzes the reduction of phosphonoacetaldehyde (PnAA) to hydroxyethylphosphoate (HEP); Region: HEPD; cd08182
326424013952	putative active site [active]
326424013953	metal binding site [ion binding]; metal-binding site
326424013954	Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111
326424013955	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
326424013956	Adenosylmethionine-8-amino-7-oxononanoate aminotransferase [Coenzyme metabolism]; Region: BioA; COG0161
326424013957	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
326424013958	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
326424013959	catalytic residue [active]
326424013960	Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657
326424013961	dinuclear metal binding motif [ion binding]; other site
326424013962	adenylosuccinate lyase; Region: PLN02848
326424013963	Phosphopantetheine attachment site; Region: PP-binding; cl09936
326424013964	PA2301 is an uncharacterized Pseudomonas aeruginosa protein with a YbaK-like domain of unknown function.  The YbaK-like domain family includes the INS amino acid-editing domain of  the bacterial class II prolyl tRNA synthetase (ProRS), and it's...; Region: PA2301; cd04939
326424013965	putative deacylase active site [active]
326424013966	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
326424013967	active site
326424013968	phosphorylation site [posttranslational modification]
326424013969	intermolecular recognition site; other site
326424013970	dimerization interface [polypeptide binding]; other site
326424013971	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
326424013972	DNA binding residues [nucleotide binding]
326424013973	dimerization interface [polypeptide binding]; other site
326424013974	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075
326424013975	yiaA/B two helix domain; Region: YiaAB; cl01759
326424013976	Putative cyclase; Region: Cyclase; cl00814
326424013977	N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357
326424013978	Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670
326424013979	MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886
326424013980	MPT binding site; other site
326424013981	trimer interface [polypeptide binding]; other site
326424013982	MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420
326424013983	trimer interface [polypeptide binding]; other site
326424013984	dimer interface [polypeptide binding]; other site
326424013985	putative active site [active]
326424013986	Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303
326424013987	MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887
326424013988	dimer interface [polypeptide binding]; other site
326424013989	putative functional site; other site
326424013990	putative MPT binding site; other site
326424013991	Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541
326424013992	active site
326424013993	tetramer interface; other site
326424013994	5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; cl00360
326424013995	Transcriptional regulators [Transcription]; Region: GntR; COG1802
326424013996	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
326424013997	DNA-binding site [nucleotide binding]; DNA binding site
326424013998	FCD domain; Region: FCD; cl11656
326424013999	Isochorismatase family; Region: Isochorismatase; pfam00857
326424014000	Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431
326424014001	catalytic triad [active]
326424014002	conserved cis-peptide bond; other site
326424014003	allophanate hydrolase; Provisional; Region: PRK08186
326424014004	Amidase; Region: Amidase; cl11426
326424014005	Transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this domain superfamily was previously known as DUF156; Region: CsoR-like_DUF156; cd10148
326424014006	putative homotetramer interface [polypeptide binding]; other site
326424014007	putative homodimer interface [polypeptide binding]; other site
326424014008	putative allosteric switch controlling residues; other site
326424014009	putative metal binding site [ion binding]; other site
326424014010	putative homodimer-homodimer interface [polypeptide binding]; other site
326424014011	Helix-turn-helix domains; Region: HTH; cl00088
326424014012	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
326424014013	2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy; cl15773
326424014014	Protein kinase domain; Region: Pkinase; pfam00069
326424014015	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
326424014016	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
326424014017	substrate binding site [chemical binding]; other site
326424014018	activation loop (A-loop); other site
326424014019	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567
326424014020	Response regulator receiver domain; Region: Response_reg; pfam00072
326424014021	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
326424014022	active site
326424014023	phosphorylation site [posttranslational modification]
326424014024	intermolecular recognition site; other site
326424014025	dimerization interface [polypeptide binding]; other site
326424014026	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054
326424014027	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
326424014028	dimerization interface [polypeptide binding]; other site
326424014029	Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840
326424014030	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
326424014031	dimerization interface [polypeptide binding]; other site
326424014032	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054
326424014033	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
326424014034	dimerization interface [polypeptide binding]; other site
326424014035	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054
326424014036	GAF domain; Region: GAF_2; pfam13185
326424014037	GAF domain; Region: GAF; cl15785
326424014038	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
326424014039	dimer interface [polypeptide binding]; other site
326424014040	phosphorylation site [posttranslational modification]
326424014041	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
326424014042	ATP binding site [chemical binding]; other site
326424014043	Mg2+ binding site [ion binding]; other site
326424014044	G-X-G motif; other site
326424014045	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
326424014046	active site
326424014047	phosphorylation site [posttranslational modification]
326424014048	intermolecular recognition site; other site
326424014049	dimerization interface [polypeptide binding]; other site
326424014050	Sigma factor PP2C-like phosphatases; Region: PP2C_SIG; smart00331
326424014051	Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cl00120
326424014052	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075
326424014053	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632
326424014054	ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424
326424014055	dimer interface [polypeptide binding]; other site
326424014056	active site
326424014057	ADP-ribose binding site [chemical binding]; other site
326424014058	nudix motif; other site
326424014059	metal binding site [ion binding]; metal-binding site
326424014060	Diaminopimelate decarboxylase [Amino acid transport and metabolism]; Region: LysA; COG0019
326424014061	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261
326424014062	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
326424014063	catalytic residue [active]
326424014064	diaminobutyrate--2-oxoglutarate aminotransferase; Provisional; Region: PRK06938
326424014065	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
326424014066	inhibitor-cofactor binding pocket; inhibition site
326424014067	pyridoxal 5'-phosphate binding site [chemical binding]; other site
326424014068	catalytic residue [active]
326424014069	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
326424014070	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
326424014071	catalytic residue [active]
326424014072	Siderophore synthetase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: RhbC; COG4264
326424014073	IucA / IucC family; Region: IucA_IucC; pfam04183
326424014074	Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276
326424014075	Lysine/ornithine N-monooxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: IucD; COG3486
326424014076	Siderophore synthetase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: RhbC; COG4264
326424014077	IucA / IucC family; Region: IucA_IucC; pfam04183
326424014078	Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276
326424014079	Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174
326424014080	Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120
326424014081	Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409
326424014082	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
326424014083	Helix-turn-helix domains; Region: HTH; cl00088
326424014084	putative glucosyl-3-phosphoglycerate synthase; Provisional; Region: PRK13915
326424014085	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
326424014086	active site
326424014087	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
326424014088	metal binding site [ion binding]; metal-binding site
326424014089	active site
326424014090	I-site; other site
326424014091	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
326424014092	Response regulator containing a CheY-like receiver domain and an HD-GYP domain [Transcription / Signal transduction mechanisms]; Region: COG3437
326424014093	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076
326424014094	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
326424014095	glycine dehydrogenase; Provisional; Region: PRK05367
326424014096	Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613
326424014097	tetramer interface [polypeptide binding]; other site
326424014098	pyridoxal 5'-phosphate binding site [chemical binding]; other site
326424014099	catalytic residue [active]
326424014100	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
326424014101	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
326424014102	catalytic residue [active]
326424014103	GlcNAc-PI de-N-acetylase; Region: PIG-L; cl00929
326424014104	Transglutaminase-like superfamily; Region: Transglut_core; cl10469
326424014105	Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721
326424014106	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057
326424014107	MoxR-like ATPases [General function prediction only]; Region: COG0714
326424014108	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
326424014109	ATP binding site [chemical binding]; other site
326424014110	Walker A motif; other site
326424014111	Walker B motif; other site
326424014112	arginine finger; other site
326424014113	Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 2 [Coenzyme metabolism]; Region: ThiF; COG0476
326424014114	ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757
326424014115	ATP binding site [chemical binding]; other site
326424014116	substrate interface [chemical binding]; other site
326424014117	DNA-binding transcriptional regulator EnvR; Provisional; Region: PRK09975
326424014118	Helix-turn-helix domains; Region: HTH; cl00088
326424014119	Glutathione-dependent formaldehyde dehydrogenase related proteins, child 1; Region: FDH_like_1; cd08283
326424014120	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
326424014121	NAD binding site [chemical binding]; other site
326424014122	catalytic Zn binding site [ion binding]; other site
326424014123	structural Zn binding site [ion binding]; other site
326424014124	Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_8; cd07817
326424014125	putative hydrophobic ligand binding site [chemical binding]; other site
326424014126	Zn-finger in ubiquitin-hydrolases and other protein; Region: zf-UBP; cl09957
326424014127	TOBE domain; Region: TOBE_2; cl01440
326424014128	TOBE domain; Region: TOBE_2; cl01440
326424014129	1-cyclohexenylcarbonyl_coenzyme A_reductase (ChcA)_like, classical (c) SDRs; Region: ChcA_like_SDR_c; cd05359
326424014130	putative NAD(P) binding site [chemical binding]; other site
326424014131	active site
326424014132	Short repeat of unknown function (DUF308); Region: DUF308; cl15828
326424014133	Iron-sulfur binding ferredoxin reductase (FNR) proteins combine the FAD and NAD(P) binding regions of FNR with an iron-sulfur binding cluster domain. Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron...; Region: FNR_iron_sulfur_binding_2; cd06216
326424014134	Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018
326424014135	FAD binding pocket [chemical binding]; other site
326424014136	FAD binding motif [chemical binding]; other site
326424014137	phosphate binding motif [ion binding]; other site
326424014138	beta-alpha-beta structure motif; other site
326424014139	NAD binding pocket [chemical binding]; other site
326424014140	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
326424014141	catalytic loop [active]
326424014142	iron binding site [ion binding]; other site
326424014143	Fatty acid desaturase [Lipid metabolism]; Region: DesA; COG3239
326424014144	The Delta6 Fatty Acid Desaturase (Delta6-FADS)-like CD includes the integral-membrane enzymes: delta-4, delta-5, delta-6, delta-8, delta-8-sphingolipid, and delta-11 desaturases found in vertebrates, higher plants, fungi, and bacteria. These desaturases...; Region: Delta6-FADS-like; cd03506
326424014145	putative di-iron ligands [ion binding]; other site
326424014146	Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840
326424014147	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
326424014148	dimerization interface [polypeptide binding]; other site
326424014149	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
326424014150	dimerization interface [polypeptide binding]; other site
326424014151	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
326424014152	dimerization interface [polypeptide binding]; other site
326424014153	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
326424014154	dimerization interface [polypeptide binding]; other site
326424014155	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
326424014156	dimerization interface [polypeptide binding]; other site
326424014157	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
326424014158	dimerization interface [polypeptide binding]; other site
326424014159	GAF domain; Region: GAF_2; pfam13185
326424014160	GAF domain; Region: GAF; cl15785
326424014161	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080
326424014162	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
326424014163	ATP binding site [chemical binding]; other site
326424014164	Mg2+ binding site [ion binding]; other site
326424014165	G-X-G motif; other site
326424014166	Response regulator receiver domain; Region: Response_reg; pfam00072
326424014167	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
326424014168	active site
326424014169	phosphorylation site [posttranslational modification]
326424014170	intermolecular recognition site; other site
326424014171	dimerization interface [polypeptide binding]; other site
326424014172	ANTAR domain; Region: ANTAR; cl04297
326424014173	putative diguanylate cyclase; Provisional; Region: PRK09776
326424014174	Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cl00120
326424014175	2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1, 4-benzoquinol methylase [Coenzyme metabolism]; Region: UbiG; COG2227
326424014176	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
326424014177	Acyl-CoA dehydrogenase; Region: ACAD; cd00567
326424014178	active site
326424014179	Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938
326424014180	active site
326424014181	uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083
326424014182	Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; cl00986
326424014183	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
326424014184	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
326424014185	This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE).  They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255
326424014186	Walker A/P-loop; other site
326424014187	ATP binding site [chemical binding]; other site
326424014188	Q-loop/lid; other site
326424014189	ABC transporter signature motif; other site
326424014190	Walker B; other site
326424014191	D-loop; other site
326424014192	H-loop/switch region; other site
326424014193	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
326424014194	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577
326424014195	FtsX-like permease family; Region: FtsX; cl15850
326424014196	Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404
326424014197	Catalytic domain of Protein Kinases; Region: PKc; cd00180
326424014198	active site
326424014199	ATP binding site [chemical binding]; other site
326424014200	substrate binding site [chemical binding]; other site
326424014201	activation loop (A-loop); other site
326424014202	3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830
326424014203	classical (c) SDRs; Region: SDR_c; cd05233
326424014204	NAD(P) binding site [chemical binding]; other site
326424014205	active site
326424014206	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: APH_ChoK_like; cd05120
326424014207	active site
326424014208	ATP binding site [chemical binding]; other site
326424014209	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057
326424014210	chaperonin GroEL; Reviewed; Region: groEL; PRK12849
326424014211	GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344
326424014212	ring oligomerisation interface [polypeptide binding]; other site
326424014213	ATP/Mg binding site [chemical binding]; other site
326424014214	stacking interactions; other site
326424014215	hinge regions; other site
326424014216	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
326424014217	Sensory domain found in DIguanylate Cyclases & Two-component systems; Region: DICT; cl01731
326424014218	Prokaryotic dksA/traR C4-type zinc finger; Region: zf-dskA_traR; cl00755
326424014219	Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cl00120
326424014220	Streptomyces sporulation and cell division protein, SsgA; Region: SsgA; pfam04686
326424014221	CYTH-like (also known as triphosphate tunnel metalloenzyme (TTM)-like) Phosphatases; Region: CYTH-like_Pase; cl11964
326424014222	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
326424014223	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009
326424014224	Isopenicillin N synthase and related dioxygenases [General function prediction only]; Region: PcbC; COG3491
326424014225	non-haem dioxygenase in morphine synthesis N-terminal; Region: DIOX_N; cl14733
326424014226	2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy; cl15773
326424014227	Domain of unknown function (DUF3291); Region: DUF3291; pfam11695
326424014228	Hemerythrin (Hr) is a non-heme diiron oxygen transport protein found in four marine invertebrate phyla including priapulida, brachiopoda, sipunculida, and annelida, as well as in protozoa. Myohemerythrin (Mhr), a hemerythrin homolog, is found in the...; Region: Hemerythrin; cl15774
326424014229	Isopentenyl diphosphate (IPP) isomerase, a member of the Nudix hydrolase superfamily, is a key enzyme in the isoprenoid biosynthetic pathway. Isoprenoids comprise a large family of natural products including sterols, carotenoids, dolichols and prenylated...; Region: IPP_Isomerase; cd02885
326424014230	active site
326424014231	metal binding site [ion binding]; metal-binding site
326424014232	nudix motif; other site
326424014233	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
326424014234	ligand binding site [chemical binding]; other site
326424014235	flexible hinge region; other site
326424014236	Isoprenoid Biosynthesis enzymes, Class 1; Region: Isoprenoid_Biosyn_C1; cl00210
326424014237	substrate binding pocket [chemical binding]; other site
326424014238	substrate-Mg2+ binding site; other site
326424014239	aspartate-rich region 1; other site
326424014240	aspartate-rich region 2; other site
326424014241	Isoprenoid Biosynthesis enzymes, Class 1; Region: Isoprenoid_Biosyn_C1; cl00210
326424014242	substrate binding pocket [chemical binding]; other site
326424014243	substrate-Mg2+ binding site; other site
326424014244	aspartate-rich region 1; other site
326424014245	aspartate-rich region 2; other site
326424014246	Protein kinase domain; Region: Pkinase; pfam00069
326424014247	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
326424014248	ABC transporter transmembrane region; Region: ABC_membrane; cl00549
326424014249	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
326424014250	Walker A/P-loop; other site
326424014251	ATP binding site [chemical binding]; other site
326424014252	Q-loop/lid; other site
326424014253	ABC transporter signature motif; other site
326424014254	Walker B; other site
326424014255	D-loop; other site
326424014256	H-loop/switch region; other site
326424014257	Predicted acetyltransferases and hydrolases with the alpha/beta hydrolase fold [General function prediction only]; Region: LipA; COG1075
326424014258	Frankia paralogous domain; Region: Frankia_40_dom; TIGR03917
326424014259	Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487
326424014260	active site
326424014261	catalytic residues [active]
326424014262	metal binding site [ion binding]; metal-binding site
326424014263	lysozyme_like domain.  This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222
326424014264	rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566
326424014265	RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; cl06870
326424014266	SpoU rRNA Methylase family; Region: SpoU_methylase; cl00362
326424014267	Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cl00120
326424014268	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057
326424014269	metal ion-dependent adhesion site (MIDAS); other site
326424014270	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
326424014271	phosphopeptide binding site; other site
326424014272	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
326424014273	tRNA synthetases class I (C) catalytic domain; Region: tRNA-synt_1e; pfam01406
326424014274	active site
326424014275	HIGH motif; other site
326424014276	nucleotide binding site [chemical binding]; other site
326424014277	catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672
326424014278	KMSKS motif; other site
326424014279	cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260
326424014280	Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381
326424014281	MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554
326424014282	homotrimer interaction site [polypeptide binding]; other site
326424014283	zinc binding site [ion binding]; other site
326424014284	CDP-binding sites; other site
326424014285	CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516
326424014286	substrate binding site; other site
326424014287	dimer interface; other site
326424014288	CarD-like/TRCF domain; Region: CarD_CdnL_TRCF; cl00588
326424014289	Protein of unknown function (DUF461); Region: DUF461; cl01071
326424014290	DNA repair protein RadA; Provisional; Region: PRK11823
326424014291	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
326424014292	Walker A motif; other site
326424014293	ATP binding site [chemical binding]; other site
326424014294	Walker B motif; other site
326424014295	DNA integrity scanning protein DisA; Provisional; Region: PRK13482
326424014296	DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457
326424014297	DisA bacterial checkpoint controller linker region; Region: DisA-linker; pfam10635
326424014298	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
326424014299	minor groove reading motif; other site
326424014300	helix-hairpin-helix signature motif; other site
326424014301	active site
326424014302	Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; cl15304
326424014303	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
326424014304	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
326424014305	DNA binding site [nucleotide binding]
326424014306	phosphate transporter ATP-binding protein; Provisional; Region: PRK14241
326424014307	Phosphate uptake is of fundamental importance in the cell physiology of bacteria because phosphate is required as a nutrient.  The Pst system of E. coli comprises four distinct subunits encoded by the pstS, pstA, pstB, and pstC genes.  The PstS protein...; Region: ABC_PstB_phosphate_transporter; cd03260
326424014308	Walker A/P-loop; other site
326424014309	ATP binding site [chemical binding]; other site
326424014310	Q-loop/lid; other site
326424014311	ABC transporter signature motif; other site
326424014312	Walker B; other site
326424014313	D-loop; other site
326424014314	H-loop/switch region; other site
326424014315	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
326424014316	dimer interface [polypeptide binding]; other site
326424014317	conserved gate region; other site
326424014318	putative PBP binding loops; other site
326424014319	ABC-ATPase subunit interface; other site
326424014320	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
326424014321	dimer interface [polypeptide binding]; other site
326424014322	conserved gate region; other site
326424014323	putative PBP binding loops; other site
326424014324	ABC-ATPase subunit interface; other site
326424014325	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
326424014326	Frankia paralogous domain; Region: Frankia_40_dom; TIGR03917
326424014327	prolyl-tRNA synthetase; Provisional; Region: PRK08661
326424014328	Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent formation of...; Region: ProRS_core_arch_euk; cd00778
326424014329	dimer interface [polypeptide binding]; other site
326424014330	motif 1; other site
326424014331	active site
326424014332	motif 2; other site
326424014333	motif 3; other site
326424014334	HGTP anticodon binding domain, as found at the C-terminus of histidyl, glycyl, threonyl and prolyl tRNA synthetases, which are classified as a group of class II aminoacyl-tRNA synthetases (aaRS). In aaRSs, the anticodon binding domain is responsible for...; Region: HGTP_anticodon; cl00266
326424014335	anticodon binding site; other site
326424014336	Phosphopantetheine attachment site; Region: PP-binding; cl09936
326424014337	Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670
326424014338	N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357
326424014339	long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07768
326424014340	AMP-binding enzyme; Region: AMP-binding; cl15778
326424014341	UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254
326424014342	putative nucleotide binding site [chemical binding]; other site
326424014343	uridine monophosphate binding site [chemical binding]; other site
326424014344	homohexameric interface [polypeptide binding]; other site
326424014345	Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385
326424014346	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
326424014347	putative active site [active]
326424014348	putative metal binding site [ion binding]; other site
326424014349	GatB domain; Region: GatB_Yqey; cl11497
326424014350	Transglycosylase; Region: Transgly; cl07896
326424014351	penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074
326424014352	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009
326424014353	PASTA domain. This domain is found at the C-termini of several Penicillin-binding proteins (PBPs) and bacterial serine/threonine kinases. It is a small globular fold consisting of 3 beta-sheets and an alpha-helix. The name PASTA is derived from PBP and...; Region: PASTA; cl02768
326424014354	Transcription factor WhiB; Region: Whib; pfam02467
326424014355	ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035
326424014356	P loop; other site
326424014357	Nucleotide binding site [chemical binding]; other site
326424014358	arsenite-activated ATPase ArsA; Region: arsA; TIGR00345
326424014359	DTAP/Switch II; other site
326424014360	Switch I; other site
326424014361	ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035
326424014362	DTAP/Switch II; other site
326424014363	Domain of unknown function (DUF4177); Region: DUF4177; pfam13783
326424014364	This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function.  The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_1; cd02199
326424014365	homotrimer interaction site [polypeptide binding]; other site
326424014366	putative active site [active]
326424014367	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447
326424014368	Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491
326424014369	Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446
326424014370	TOMM system kinase/cyclase multidomain protein; Region: TOMM_kin_cyc; TIGR03903
326424014371	cyclase homology domain; Region: CHD; cd07302
326424014372	nucleotidyl binding site; other site
326424014373	metal binding site [ion binding]; metal-binding site
326424014374	dimer interface [polypeptide binding]; other site
326424014375	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
326424014376	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
326424014377	TPR motif; other site
326424014378	binding surface
326424014379	Tetratricopeptide repeat; Region: TPR_12; pfam13424
326424014380	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
326424014381	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
326424014382	ligand binding site [chemical binding]; other site
326424014383	flexible hinge region; other site
326424014384	Helix-turn-helix domains; Region: HTH; cl00088
326424014385	Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177
326424014386	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
326424014387	minor groove reading motif; other site
326424014388	helix-hairpin-helix signature motif; other site
326424014389	substrate binding pocket [chemical binding]; other site
326424014390	active site
326424014391	Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; cl15304
326424014392	Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426
326424014393	putative active site [active]
326424014394	putative CoA binding site [chemical binding]; other site
326424014395	nudix motif; other site
326424014396	metal binding site [ion binding]; metal-binding site
326424014397	Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; cl11412
326424014398	Colicin V production protein; Region: Colicin_V; cl00567
326424014399	Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149
326424014400	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
326424014401	Protein of unknown function (DUF1469); Region: DUF1469; cl12095
326424014402	helicase/secretion neighborhood CpaE-like protein; Region: CpaE_hom_Actino; TIGR03815
326424014403	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
326424014404	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
326424014405	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
326424014406	ATP binding site [chemical binding]; other site
326424014407	Walker B motif; other site
326424014408	Protein of unknown function (DUF4244); Region: DUF4244; pfam14029
326424014409	helicase/secretion neighborhood TadE-like protein; Region: tadE_like_DECH; TIGR03816
326424014410	MAEBL; Provisional; Region: PTZ00121
326424014411	helicase/secretion neighborhood putative DEAH-box helicase; Region: DECH_helic; TIGR03817
326424014412	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
326424014413	ATP binding site [chemical binding]; other site
326424014414	putative Mg++ binding site [ion binding]; other site
326424014415	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
326424014416	nucleotide binding region [chemical binding]; other site
326424014417	ATP-binding site [chemical binding]; other site
326424014418	Domain of unknown function (DUF1998); Region: DUF1998; pfam09369
326424014419	Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043
326424014420	anti sigma factor interaction site; other site
326424014421	regulatory phosphorylation site [posttranslational modification]; other site
326424014422	Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581
326424014423	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075
326424014424	membrane-bound proton-translocating pyrophosphatase; Validated; Region: hppA; PRK00733
326424014425	Inorganic pyrophosphatase [Energy production and conversion]; Region: OVP1; cl11452
326424014426	DNA topoisomerase I subunit omega; Validated; Region: PRK07561
326424014427	TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I.   Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363
326424014428	active site
326424014429	interdomain interaction site; other site
326424014430	putative metal-binding site [ion binding]; other site
326424014431	nucleotide binding site [chemical binding]; other site
326424014432	DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cl11986
326424014433	domain I; other site
326424014434	phosphate binding site [ion binding]; other site
326424014435	DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186
326424014436	domain II; other site
326424014437	domain III; other site
326424014438	nucleotide binding site [chemical binding]; other site
326424014439	DNA binding groove [nucleotide binding]
326424014440	catalytic site [active]
326424014441	domain IV; other site
326424014442	Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368
326424014443	Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368
326424014444	Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368
326424014445	Transmembrane secretion effector; Region: MFS_3; pfam05977
326424014446	thymidylate kinase; Validated; Region: tmk; PRK00698
326424014447	Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672
326424014448	TMP-binding site; other site
326424014449	ATP-binding site [chemical binding]; other site
326424014450	DNA polymerase III, delta' subunit; Region: holB; TIGR00678
326424014451	PSP1 C-terminal conserved region; Region: PSP1; cl00770
326424014452	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
326424014453	active site
326424014454	phosphorylation site [posttranslational modification]
326424014455	intermolecular recognition site; other site
326424014456	dimerization interface [polypeptide binding]; other site
326424014457	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
326424014458	DNA binding site [nucleotide binding]
326424014459	Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412
326424014460	dimer interface [polypeptide binding]; other site
326424014461	substrate binding site [chemical binding]; other site
326424014462	metal binding sites [ion binding]; metal-binding site
326424014463	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009
326424014464	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009
326424014465	Uncharacterized conserved protein (DUF2342); Region: DUF2342; cl02183
326424014466	N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992
326424014467	Ligand Binding Site [chemical binding]; other site
326424014468	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
326424014469	active site
326424014470	ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241
326424014471	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
326424014472	Walker A motif; other site
326424014473	ATP binding site [chemical binding]; other site
326424014474	Walker B motif; other site
326424014475	arginine finger; other site
326424014476	Peptidase family M41; Region: Peptidase_M41; pfam01434
326424014477	GTP cyclohydrolase I; Provisional; Region: PLN03044
326424014478	GTP cyclohydrolase I (GTP-CH-I) catalyzes the conversion of GTP into dihydroneopterin triphosphate.  The enzyme product is the precursor of tetrahydrofolate in eubacteria, fungi, and plants and of the folate analogs in methanogenic bacteria.  In...; Region: GTP_cyclohydro1; cd00642
326424014479	homodecamer interface [polypeptide binding]; other site
326424014480	active site
326424014481	putative catalytic site residues [active]
326424014482	zinc binding site [ion binding]; other site
326424014483	GTP-CH-I/GFRP interaction surface; other site
326424014484	ATP phosphoribosyltransferase; Reviewed; Region: hisG; PRK00489
326424014485	ATP phosphoribosyltransferase; Region: HisG; cl15266
326424014486	HisG, C-terminal domain; Region: HisG_C; cl06867
326424014487	MazG nucleotide pyrophosphohydrolase domain; Region: MazG; cl00345
326424014488	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
326424014489	haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282
326424014490	active site
326424014491	motif I; other site
326424014492	motif II; other site
326424014493	Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391
326424014494	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
326424014495	non-specific DNA binding site [nucleotide binding]; other site
326424014496	salt bridge; other site
326424014497	sequence-specific DNA binding site [nucleotide binding]; other site
326424014498	Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; cl00398
326424014499	Putative modulator of DNA gyrase; Region: PmbA_TldD; pfam01523
326424014500	Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; cl00398
326424014501	Protein of unknown function (DUF2587); Region: DUF2587; pfam10759
326424014502	putative NAD(P)H quinone oxidoreductase, PIG3 family; Region: quinone_pig3; TIGR02824
326424014503	PIG3 p53-inducible quinone oxidoreductase; Region: p53_inducible_oxidoreductase; cd05276
326424014504	NAD(P) binding site [chemical binding]; other site
326424014505	Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer,  utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514
326424014506	FMN binding site [chemical binding]; other site
326424014507	dimer interface [polypeptide binding]; other site
326424014508	RNA polymerase sigma-70 factor, sigma-E family; Region: SigE-fam_strep; TIGR02983
326424014509	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
326424014510	DNA binding residues [nucleotide binding]
326424014511	Glucitol operon activator protein (GutM); Region: GutM; cl01890
326424014512	Domain of unknown function (DUF3817); Region: DUF3817; cl14844
326424014513	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
326424014514	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
326424014515	non-specific DNA binding site [nucleotide binding]; other site
326424014516	salt bridge; other site
326424014517	sequence-specific DNA binding site [nucleotide binding]; other site
326424014518	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
326424014519	Helix-turn-helix domains; Region: HTH; cl00088
326424014520	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
326424014521	Major Facilitator Superfamily; Region: MFS_1; pfam07690
326424014522	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
326424014523	Fusaric acid resistance protein-like; Region: FUSC_2; cl15844
326424014524	ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730
326424014525	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
326424014526	The BcrA subfamily represents ABC transporters involved in peptide antibiotic resistance.  Bacitracin is a dodecapeptide antibiotic produced by B. licheniformis and B. subtilis.  The synthesis of bacitracin is non-ribosomally catalyzed by a multienzyme...; Region: ABC_BcrA_bacitracin_resist; cd03268
326424014527	Walker A/P-loop; other site
326424014528	ATP binding site [chemical binding]; other site
326424014529	Q-loop/lid; other site
326424014530	ABC transporter signature motif; other site
326424014531	Walker B; other site
326424014532	D-loop; other site
326424014533	H-loop/switch region; other site
326424014534	GAF domain; Region: GAF; cl15785
326424014535	ANTAR domain; Region: ANTAR; cl04297
326424014536	Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043
326424014537	anti sigma factor interaction site; other site
326424014538	regulatory phosphorylation site [posttranslational modification]; other site
326424014539	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
326424014540	F420-dependent oxidoreductase, MSMEG_4879 family; Region: F420_MSMEG_4879; TIGR03564
326424014541	Predicted glutamine amidotransferase [General function prediction only]; Region: COG0121
326424014542	Glutamine amidotransferases class-II (Gn-AT)_YafJ-type.  YafJ is a glutamine amidotransferase-like protein of unknown function found in prokaryotes, eukaryotes and archaea.  YafJ has a conserved structural fold similar to those of other class II...; Region: YafJ; cd01908
326424014543	putative active site [active]
326424014544	putative dimer interface [polypeptide binding]; other site
326424014545	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
326424014546	Glycosyltransferase Family 4; Region: Glyco_transf_4; pfam13439
326424014547	ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192
326424014548	ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192
326424014549	ATP binding site [chemical binding]; other site
326424014550	substrate binding site [chemical binding]; other site
326424014551	Fibronectin type III-like domain; Region: Fn3-like; cl15273
326424014552	legume lectins; Region: lectin_L-type; cl14058
326424014553	homotetramer interaction site [polypeptide binding]; other site
326424014554	carbohydrate binding site [chemical binding]; other site
326424014555	metal binding site [ion binding]; metal-binding site
326424014556	Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063
326424014557	Interdomain contacts; other site
326424014558	Cytokine receptor motif; other site
326424014559	Cadherin repeat-like domain; Region: CA_like; cl15786
326424014560	Cadherin repeat-like domain; Region: CA_like; cl15786
326424014561	Fibronectin type III-like domain; Region: Fn3-like; cl15273
326424014562	Fibronectin type III-like domain; Region: Fn3-like; cl15273
326424014563	Trehalose and maltose hydrolases (possible phosphorylases) [Carbohydrate transport and metabolism]; Region: ATH1; COG1554
326424014564	Glycosyl hydrolase family 65, N-terminal domain; Region: Glyco_hydro_65N; pfam03636
326424014565	Glycosyl hydrolase family 65 central catalytic domain; Region: Glyco_hydro_65m; pfam03632
326424014566	Glycosyl hydrolase family 65, C-terminal domain; Region: Glyco_hydro_65C; pfam03633
326424014567	beta-phosphoglucomutase family hydrolase; Region: PGMB-YQAB-SF; TIGR02009
326424014568	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
326424014569	motif II; other site
326424014570	Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557
326424014571	trimer interface [polypeptide binding]; other site
326424014572	active site
326424014573	4Fe-4S binding domain; Region: Fer4; cl02805
326424014574	Cysteine-rich domain; Region: CCG; pfam02754
326424014575	Cysteine-rich domain; Region: CCG; pfam02754
326424014576	Nuclease-related domain; Region: NERD; pfam08378
326424014577	molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290
326424014578	GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446
326424014579	dimer interface [polypeptide binding]; other site
326424014580	hsp70 (ATPase domain) interactions [polypeptide binding]; other site
326424014581	chaperone protein DnaJ; Region: DnaJ_bact; TIGR02349
326424014582	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
326424014583	HSP70 interaction site [polypeptide binding]; other site
326424014584	Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719
326424014585	Zn binding sites [ion binding]; other site
326424014586	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747
326424014587	dimer interface [polypeptide binding]; other site
326424014588	Helix-Turn-Helix DNA binding domain of the HspR transcription regulator; Region: HTH_HspR; cd04766
326424014589	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
326424014590	DNA binding residues [nucleotide binding]
326424014591	putative dimer interface [polypeptide binding]; other site
326424014592	ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346
326424014593	Clp amino terminal domain; Region: Clp_N; pfam02861
326424014594	Clp amino terminal domain; Region: Clp_N; pfam02861
326424014595	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
326424014596	Walker A motif; other site
326424014597	ATP binding site [chemical binding]; other site
326424014598	Walker B motif; other site
326424014599	arginine finger; other site
326424014600	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
326424014601	Walker A motif; other site
326424014602	ATP binding site [chemical binding]; other site
326424014603	Walker B motif; other site
326424014604	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; cl11083
326424014605	Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381
326424014606	Indigoidine synthase A like protein; Region: Indigoidine_A; cl00983
326424014607	Transport protein; Region: actII; TIGR00833
326424014608	Protein export membrane protein; Region: SecD_SecF; cl14618
326424014609	Bacterial PH domain; Region: DUF304; cl01348
326424014610	Bacterial PH domain; Region: DUF304; cl01348
326424014611	Bacterial PH domain; Region: DUF304; cl01348
326424014612	Bacterial PH domain; Region: DUF304; cl01348
326424014613	Nucleotidyltransferase (NT) domain of 2'5'-oligoadenylate (2-5A)synthetase (2-5OAS) and class I CCA-adding enzyme; Region: NT_2-5OAS_ClassI-CCAase; cd05400
326424014614	active site
326424014615	NTP binding site [chemical binding]; other site
326424014616	metal binding triad [ion binding]; metal-binding site
326424014617	SCP: SCP-like extracellular protein domain, found in eukaryotes and prokaryotes. This family includes plant pathogenesis-related protein 1 (PR-1), which accumulates after infections with pathogens, and may act as an anti-fungal agent or be involved in...; Region: SCP; cl00133
326424014618	SNARE associated Golgi protein; Region: SNARE_assoc; cl00429
326424014619	fructose-bisphosphate aldolase; Provisional; Region: PRK09197
326424014620	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl09108
326424014621	active site
326424014622	intersubunit interface [polypeptide binding]; other site
326424014623	zinc binding site [ion binding]; other site
326424014624	Na+ binding site [ion binding]; other site
326424014625	lysozyme_like domain.  This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222
326424014626	Putative peptidoglycan binding domain; Region: PG_binding_1; cl15437
326424014627	lysozyme_like domain.  This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222
326424014628	Protein of unknown function (DUF3151); Region: DUF3151; pfam11349
326424014629	Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788
326424014630	Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108
326424014631	GDP-binding site [chemical binding]; other site
326424014632	ACT binding site; other site
326424014633	IMP binding site; other site
326424014634	phosphoribosylamine--glycine ligase; Region: purD; TIGR00877
326424014635	Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844
326424014636	ATP-grasp domain; Region: ATP-grasp_4; cl03087
326424014637	Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843
326424014638	AIR carboxylase; Region: AIRC; cl00310
326424014639	adenylosuccinate lyase; Provisional; Region: PRK07492
326424014640	Adenylsuccinate lyase (ASL)_subgroup 1; Region: Adenylsuccinate_lyase_1; cd01360
326424014641	tetramer interface [polypeptide binding]; other site
326424014642	active site
326424014643	Lyase class I_like superfamily: contains the lyase class I family, histidine ammonia-lyase and phenylalanine ammonia-lyase, which catalyze similar beta-elimination reactions; Region: Lyase_I_like; cl00013
326424014644	non-metazoan 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_Sc; cd01414
326424014645	ATP binding site [chemical binding]; other site
326424014646	active site
326424014647	substrate binding site [chemical binding]; other site
326424014648	Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409
326424014649	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
326424014650	pantoate--beta-alanine ligase; Region: panC; TIGR00018
326424014651	active site
326424014652	nucleotide binding site [chemical binding]; other site
326424014653	HIGH motif; other site
326424014654	KMSKS motif; other site
326424014655	Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent  decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919
326424014656	tetramerization interface [polypeptide binding]; other site
326424014657	active site
326424014658	L-aspartate oxidase; Provisional; Region: PRK07804
326424014659	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
326424014660	Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910
326424014661	nicotinate-nucleotide pyrophosphorylase; Provisional; Region: PRK07896
326424014662	Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572
326424014663	dimerization interface [polypeptide binding]; other site
326424014664	active site
326424014665	Type III pantothenate kinase; Region: Pan_kinase; cl09130
326424014666	SEST_like. A family of secreted SGNH-hydrolases similar to Streptomyces scabies esterase (SEST), a causal agent of the potato scab disease, which hydrolyzes a specific ester bond in suberin, a plant lipid. The tertiary fold of this enzyme is...; Region: SEST_like; cd01823
326424014667	active site
326424014668	catalytic triad [active]
326424014669	oxyanion hole [active]
326424014670	Uncharacterized protein family (UPF0150); Region: UPF0150; cl00691
326424014671	YcfA-like protein; Region: YcfA; cl00752
326424014672	FhuF 2Fe-2S C-terminal domain; Region: FhuF_C; pfam11575
326424014673	Clp protease ATP binding subunit; Region: clpC; CHL00095
326424014674	Clp amino terminal domain; Region: Clp_N; pfam02861
326424014675	Clp amino terminal domain; Region: Clp_N; pfam02861
326424014676	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
326424014677	Walker A motif; other site
326424014678	ATP binding site [chemical binding]; other site
326424014679	Walker B motif; other site
326424014680	arginine finger; other site
326424014681	UvrB/uvrC motif; Region: UVR; pfam02151
326424014682	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
326424014683	Walker A motif; other site
326424014684	ATP binding site [chemical binding]; other site
326424014685	Walker B motif; other site
326424014686	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; cl11083
326424014687	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
326424014688	active site
326424014689	metal binding site [ion binding]; metal-binding site
326424014690	Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cl00120
326424014691	active site
326424014692	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
326424014693	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
326424014694	EamA-like transporter family; Region: EamA; cl01037
326424014695	carotene biosynthesis associated membrane protein; Region: crt_membr; TIGR03459
326424014696	Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334
326424014697	Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812
326424014698	NAD(P) binding domain of glutamate dehydrogenase, subgroup 1; Region: NAD_bind_1_Glu_DH; cd01076
326424014699	NAD(P) binding site [chemical binding]; other site
326424014700	RNHCP domain; Region: RNHCP; pfam12647
326424014701	Protein of unknown function (DUF3263); Region: DUF3263; pfam11662
326424014702	LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399
326424014703	Trehalose-6-phosphatase [Carbohydrate transport and metabolism]; Region: OtsB; COG1877
326424014704	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
326424014705	active site
326424014706	motif I; other site
326424014707	motif II; other site
326424014708	Trehalose-6-Phosphate Synthase (TPS) is a glycosyltransferase that catalyses the synthesis of alpha,alpha-1,1-trehalose-6-phosphate from glucose-6-phosphate using a UDP-glucose donor. It is a key enzyme in the trehalose synthesis pathway. Trehalose is a...; Region: GT1_TPS; cd03788
326424014709	Glycosyltransferase family 20; Region: Glyco_transf_20; pfam00982
326424014710	active site
326424014711	homotetramer interface [polypeptide binding]; other site
326424014712	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
326424014713	sucrose-phosphate phosphatase subfamily; Region: SPP-subfamily; TIGR01482
326424014714	active site
326424014715	motif I; other site
326424014716	motif II; other site
326424014717	Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391
326424014718	threonine synthase; Validated; Region: PRK07591
326424014719	Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of  threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants; Region: Thr-synth_1; cd01563
326424014720	homodimer interface [polypeptide binding]; other site
326424014721	pyridoxal 5'-phosphate binding site [chemical binding]; other site
326424014722	catalytic residue [active]
326424014723	chaperonin GroEL; Reviewed; Region: groEL; PRK12849
326424014724	GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344
326424014725	ring oligomerisation interface [polypeptide binding]; other site
326424014726	ATP/Mg binding site [chemical binding]; other site
326424014727	stacking interactions; other site
326424014728	hinge regions; other site
326424014729	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
326424014730	putative active site [active]
326424014731	Helicase conserved C-terminal domain; Region: Helicase_C_3; pfam13625
326424014732	DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061
326424014733	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
326424014734	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
326424014735	ATP binding site [chemical binding]; other site
326424014736	putative Mg++ binding site [ion binding]; other site
326424014737	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
326424014738	nucleotide binding region [chemical binding]; other site
326424014739	ATP-binding site [chemical binding]; other site
326424014740	Helicase conserved C-terminal domain; Region: Helicase_C_3; pfam13625
326424014741	WYL domain; Region: WYL; cl14852
326424014742	Protein of unknown function (DUF3180); Region: DUF3180; pfam11377
326424014743	7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483
326424014744	catalytic center binding site [active]
326424014745	ATP binding site [chemical binding]; other site
326424014746	Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534
326424014747	homooctamer interface [polypeptide binding]; other site
326424014748	active site
326424014749	Pterin binding enzymes. This family includes dihydropteroate synthase (DHPS) and cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH).  DHPS, a...; Region: Pterin_binding; cl00219
326424014750	substrate binding pocket [chemical binding]; other site
326424014751	inhibitor binding site; inhibition site
326424014752	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
326424014753	PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392
326424014754	active site
326424014755	transcription termination factor Rho; Provisional; Region: PRK12678
326424014756	Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455
326424014757	geranylgeranyl reductase family; Region: GG-red-SF; TIGR02032
326424014758	Predicted NAD/FAD-dependent oxidoreductase [General function prediction only]; Region: COG3380
326424014759	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075
326424014760	Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740
326424014761	putative active site [active]
326424014762	catalytic triad [active]
326424014763	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
326424014764	OpuCA is a the ATP binding component of a bacterial solute transporter that serves a protective role to cells growing in a hyperosmolar environment.  ABC (ATP-binding cassette) transporter nucleotide-binding domain; ABC transporters are a large family of...; Region: ABC_OpuCA_Osmoprotection; cd03295
326424014765	Walker A/P-loop; other site
326424014766	ATP binding site [chemical binding]; other site
326424014767	Q-loop/lid; other site
326424014768	ABC transporter signature motif; other site
326424014769	Walker B; other site
326424014770	D-loop; other site
326424014771	H-loop/switch region; other site
326424014772	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427
326424014773	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
326424014774	dimer interface [polypeptide binding]; other site
326424014775	conserved gate region; other site
326424014776	ABC-ATPase subunit interface; other site
326424014777	NMT1-like family; Region: NMT1_2; cl15260
326424014778	Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069
326424014779	phosphoribosylformylglycinamidine synthase II; Provisional; Region: PRK01213
326424014780	PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203
326424014781	dimerization interface [polypeptide binding]; other site
326424014782	ATP binding site [chemical binding]; other site
326424014783	PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204
326424014784	dimerization interface [polypeptide binding]; other site
326424014785	ATP binding site [chemical binding]; other site
326424014786	Protein of unknown function (DUF3027); Region: DUF3027; pfam11228
326424014787	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
326424014788	putative substrate translocation pore; other site
326424014789	DNA polymerase III subunits gamma and tau; Validated; Region: PRK07003
326424014790	Phosphorylase superfamily; Region: PNP_UDP_1; cl00303
326424014791	NMT1-like family; Region: NMT1_2; cl15260
326424014792	Formamidopyrimidine-DNA glycosylase [DNA replication, recombination, and repair]; Region: Nei; COG0266
326424014793	Uncharacterized bacterial subgroup of the N-terminal domain of Fpg (formamidopyrimidine-DNA glycosylase, MutM)_Nei  (endonuclease VIII) base-excision repair DNA glycosylases; Region: BaFpgNei_N_1; cd08973
326424014794	putative DNA binding site [nucleotide binding]; other site
326424014795	catalytic residue [active]
326424014796	putative H2TH interface [polypeptide binding]; other site
326424014797	putative catalytic residues [active]
326424014798	Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831
326424014799	Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827
326424014800	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
326424014801	active site residue [active]
326424014802	Phosphoribosylformylglycinamidine (FGAM) synthase; Region: PurS; cl00789
326424014803	Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391
326424014804	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box protein; Region: CSP_CDS; cd04458
326424014805	DNA-binding site [nucleotide binding]; DNA binding site
326424014806	RNA-binding motif; other site
326424014807	Protein kinase domain; Region: Pkinase; pfam00069
326424014808	Catalytic domain of Protein Kinases; Region: PKc; cd00180
326424014809	active site
326424014810	ATP binding site [chemical binding]; other site
326424014811	substrate binding site [chemical binding]; other site
326424014812	activation loop (A-loop); other site
326424014813	Domain of unknown function (DUF4352); Region: DUF4352; pfam11611
326424014814	mycofactocin system transcriptional regulator; Region: mycofact_TetR; TIGR03968
326424014815	Helix-turn-helix domains; Region: HTH; cl00088
326424014816	Protein of unknown function DUF262; Region: DUF262; cl14890
326424014817	Protein of unknown function (DUF2662); Region: DUF3662; pfam12401
326424014818	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
326424014819	phosphopeptide binding site; other site
326424014820	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
326424014821	phosphopeptide binding site; other site
326424014822	Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143
326424014823	active site
326424014824	Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511
326424014825	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009
326424014826	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
326424014827	Catalytic domain of Protein Kinases; Region: PKc; cd00180
326424014828	active site
326424014829	ATP binding site [chemical binding]; other site
326424014830	substrate binding site [chemical binding]; other site
326424014831	activation loop (A-loop); other site
326424014832	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
326424014833	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
326424014834	active site
326424014835	ATP binding site [chemical binding]; other site
326424014836	substrate binding site [chemical binding]; other site
326424014837	activation loop (A-loop); other site
326424014838	PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577
326424014839	PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577
326424014840	PASTA domain. This domain is found at the C-termini of several Penicillin-binding proteins (PBPs) and bacterial serine/threonine kinases. It is a small globular fold consisting of 3 beta-sheets and an alpha-helix. The name PASTA is derived from PBP and...; Region: PASTA; cl02768
326424014841	Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743
326424014842	Glutamine amidotransferase class-I; Region: GATase; pfam00117
326424014843	glutamine binding [chemical binding]; other site
326424014844	catalytic triad [active]
326424014845	Bacterial protein of unknown function (DUF881); Region: DUF881; pfam05949
326424014846	This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function.  The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_6; cd06154
326424014847	homotrimer interaction site [polypeptide binding]; other site
326424014848	putative active site [active]
326424014849	Glucoamylase and related glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: SGA1; COG3387
326424014850	Glycosyl hydrolases family 15; Region: Glyco_hydro_15; pfam00723
326424014851	Protein of unknown function (DUF2581); Region: DUF2581; pfam10756
326424014852	Rhomboid family; Region: Rhomboid; cl11446
326424014853	peptidyl-prolyl cis-trans isomerase B (rotamase B); Provisional; Region: PRK10791
326424014854	cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317
326424014855	active site
326424014856	Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303
326424014857	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
326424014858	GMC oxidoreductase; Region: GMC_oxred_C; pfam05199
326424014859	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
326424014860	Ligand Binding Site [chemical binding]; other site
326424014861	Calpains, domains IIa, IIb; calcium-dependent cytoplasmic cysteine proteinases, papain-like. Functions in cytoskeletal remodeling processes, cell differentiation, apoptosis and signal transduction; Region: CysPc; cl00051
326424014862	catalytic site [active]
326424014863	acetyl-CoA acetyltransferase; Provisional; Region: PRK07851
326424014864	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
326424014865	dimer interface [polypeptide binding]; other site
326424014866	active site
326424014867	PAP2_like proteins, Aur1_like subfamily. Yeast Aur1p or Ipc1p is necessary for the addition of inositol phosphate to ceramide, an essential step in yeast sphingolipid synthesis, and is the target of several antifungal compounds such as aureobasidin; Region: PAP2_Aur1_like; cd03386
326424014868	active site
326424014869	Domain of unknown function (DUF1918); Region: DUF1918; pfam08940
326424014870	Predicted exporters of the RND superfamily [General function prediction only]; Region: COG1033
326424014871	Predicted exporters of the RND superfamily [General function prediction only]; Region: COG1033
326424014872	S-adenosyl-L-homocysteine hydrolase (AdoHycase) catalyzes the hydrolysis of S-adenosyl-L-homocysteine (AdoHyc) to form adenosine (Ado) and homocysteine (Hcy). The equilibrium lies far on the side of AdoHyc synthesis, but in nature the removal of Ado and...; Region: AdoHcyase; cd00401
326424014873	Adenosylhomocysteinase; Provisional; Region: PTZ00075
326424014874	oligomerization interface [polypeptide binding]; other site
326424014875	active site
326424014876	NAD+ binding site [chemical binding]; other site
326424014877	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
326424014878	Coenzyme A binding pocket [chemical binding]; other site
326424014879	N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357
326424014880	Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583
326424014881	substrate binding site [chemical binding]; other site
326424014882	amidase catalytic site [active]
326424014883	Zn binding residues [ion binding]; other site
326424014884	Putative peptidoglycan binding domain; Region: PG_binding_1; cl15437
326424014885	Glycerate kinase family; Region: Gly_kinase; cl00841
326424014886	Adenosine deaminase [Nucleotide transport and metabolism]; Region: Add; COG1816
326424014887	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
326424014888	active site
326424014889	Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_8; cd07817
326424014890	putative hydrophobic ligand binding site [chemical binding]; other site
326424014891	Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020
326424014892	conserved cys residue [active]
326424014893	chromosome replication initiation inhibitor protein; Validated; Region: PRK03635
326424014894	Helix-turn-helix domains; Region: HTH; cl00088
326424014895	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box protein; Region: CSP_CDS; cd04458
326424014896	DNA-binding site [nucleotide binding]; DNA binding site
326424014897	RNA-binding motif; other site
326424014898	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
326424014899	S-adenosylmethionine binding site [chemical binding]; other site
326424014900	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
326424014901	active site
326424014902	phosphorylation site [posttranslational modification]
326424014903	intermolecular recognition site; other site
326424014904	superfamily containing globins and truncated hemoglobins; Region: globin_like; cl00280
326424014905	heme-binding site [chemical binding]; other site
326424014906	Helix-turn-helix domains; Region: HTH; cl00088
326424014907	Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702
326424014908	triphenylmethane reductase (TMR)-like proteins, NMRa-like, atypical (a) SDRs; Region: TMR_SDR_a; cd05269
326424014909	NADP binding site [chemical binding]; other site
326424014910	[FeFe] hydrogenase, group B1/B3; Region: FeFe_hydrog_B1; TIGR04105
326424014911	4Fe-4S binding domain; Region: Fer4; cl02805
326424014912	Uncharacterized anaerobic dehydrogenase [General function prediction only]; Region: COG3383
326424014913	Thiamine pyrophosphate (TPP family), 2-oxoglutarate ferredoxin oxidoreductase (OGFOR) subfamily, TPP-binding module; OGFOR catalyzes the oxidative decarboxylation of 2-oxo-acids, with ferredoxin acting as an electron acceptor. In the TCA cycle, OGFOR...; Region: TPP_OGFOR; cd03375
326424014914	TPP-binding site [chemical binding]; other site
326424014915	2-oxoglutarate ferredoxin oxidoreductase subunit beta; Reviewed; Region: PRK11867
326424014916	Pyruvate ferredoxin/flavodoxin oxidoreductase; Region: POR; cl00546
326424014917	2-oxoacid:acceptor oxidoreductase, alpha subunit; Region: OAFO_sf; TIGR03710
326424014918	Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034
326424014919	dimer interface [polypeptide binding]; other site
326424014920	PYR/PP interface [polypeptide binding]; other site
326424014921	TPP binding site [chemical binding]; other site
326424014922	substrate binding site [chemical binding]; other site
326424014923	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
326424014924	cysteine desulfurase DndA; Region: DNA_S_dndA; TIGR03235
326424014925	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
326424014926	catalytic residue [active]
326424014927	Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 2 [Coenzyme metabolism]; Region: ThiF; COG0476
326424014928	ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757
326424014929	ATP binding site [chemical binding]; other site
326424014930	substrate interface [chemical binding]; other site
326424014931	Iron-sulphur cluster biosynthesis; Region: Fe-S_biosyn; cl00400
326424014932	NifU-like domain; Region: NifU; cl00484
326424014933	nitrogenase cofactor biosynthesis protein NifB; Region: nifB; TIGR01290
326424014934	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
326424014935	FeS/SAM binding site; other site
326424014936	NifB belongs to a family of iron-molybdenum cluster-binding proteins that includes NifX, and NifY, all of which are involved in the synthesis of an iron-molybdenum cofactor (FeMo-co) that binds the active site of the dinitrogenase enzyme as part of...; Region: NifB; cd00852
326424014937	NifZ domain; Region: NifZ; pfam04319
326424014938	Nitrogen fixation protein NifW; Region: NifW; cl03935
326424014939	Rop-like; Region: Rop-like; cl02247
326424014940	Protein of unknown function, DUF269; Region: DUF269; cl03973
326424014941	This CD represents a family of iron-molybdenum cluster-binding proteins that includes NifB, NifX, and NifY, all of which are involved in the synthesis of an iron-molybdenum cofactor (FeMo-co) that binds the active site of the dinitrogenase enzyme.  This...; Region: NifX_NifB; cl00252
326424014942	The nitrogenase enzyme system catalyzes the ATP-dependent reduction of dinitrogen to ammonia.  This group contains both alpha and beta subunits of component 1 of the three known genetically distinct types of nitrogenase systems: a molybdenum-dependent; Region: Oxidoreductase_nitrogenase; cl02775
326424014943	The nitrogenase enzyme system catalyzes the ATP-dependent reduction of dinitrogen to ammonia.  This group contains both alpha and beta subunits of component 1 of the three known genetically distinct types of nitrogenase systems: a molybdenum-dependent; Region: Oxidoreductase_nitrogenase; cl02775
326424014944	nitrogenase molybdenum-iron cofactor biosynthesis protein NifE; Region: nifE; TIGR01283
326424014945	The nitrogenase enzyme system catalyzes the ATP-dependent reduction of dinitrogen to ammonia.  This group contains both alpha and beta subunits of component 1 of the three known genetically distinct types of nitrogenase systems: a molybdenum-dependent; Region: Oxidoreductase_nitrogenase; cl02775
326424014946	nitrogenase molybdenum-iron protein beta chain; Region: nifK; TIGR01286
326424014947	Domain of unknown function (DUF3364); Region: DUF3364; pfam11844
326424014948	Nitrogenase_MoFe_beta: Nitrogenase MoFe protein, beta subunit. The nitrogenase enzyme catalyzes the ATP-dependent reduction of dinitrogen to ammonia. The Molybdenum (Mo-) nitrogenase is the most widespread and best characterized of these systems; Region: Nitrogenase_MoFe_beta; cd01974
326424014949	MoFe protein beta/alpha subunit interactions; other site
326424014950	Beta subunit P cluster binding residues; other site
326424014951	MoFe protein beta subunit/Fe protein contacts; other site
326424014952	MoFe protein dimer/ dimer interactions; other site
326424014953	nitrogenase molybdenum-iron cofactor biosynthesis protein NifE; Region: nifE; TIGR01283
326424014954	Nitrogenase_MoFe_alpha_II: Nitrogenase MoFe protein, beta subunit. A group of proteins similar to the alpha subunit of the MoFe protein of the molybdenum (Mo-) nitrogenase. The nitrogenase enzyme catalyzes the ATP-dependent reduction of dinitrogen to...; Region: Nitrogenase_MoFe_alpha; cd01976
326424014955	MoFe protein alpha/beta subunit interactions; other site
326424014956	Alpha subunit P cluster binding residues; other site
326424014957	FeMoco binding residues [chemical binding]; other site
326424014958	MoFe protein alpha subunit/Fe protein contacts; other site
326424014959	MoFe protein dimer/ dimer interactions; other site
326424014960	nitrogenase reductase; Reviewed; Region: nifH; PRK13234
326424014961	NifH gene encodes component II (iron protein) of nitrogenase. Nitrogenase is responsible for the biological nitrogen fixation, i.e. reduction of molecular nitrogen to ammonia. NifH consists of two oxygen-sensitive metallosulfur proteins: the...; Region: NifH; cd02040
326424014962	Nucleotide-binding sites [chemical binding]; other site
326424014963	Walker A motif; other site
326424014964	Switch I region of nucleotide binding site; other site
326424014965	Fe4S4 binding sites [ion binding]; other site
326424014966	Switch II region of nucleotide binding site; other site
326424014967	homocitrate synthase NifV; Region: nifV_homocitr; TIGR02660
326424014968	Streptomyces rubellomurinus FrbC and related proteins, catalytic TIM barrel domain; Region: DRE_TIM_NifV; cd07939
326424014969	active site
326424014970	catalytic residues [active]
326424014971	metal binding site [ion binding]; metal-binding site
326424014972	Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695
326424014973	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
326424014974	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
326424014975	Helix-turn-helix domains; Region: HTH; cl00088
326424014976	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
326424014977	S-adenosylmethionine binding site [chemical binding]; other site
326424014978	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
326424014979	Helix-Turn-Helix DNA binding domain of truncated MerR-like proteins; Region: HTH_MerR-trunc; cd04762
326424014980	DNA binding residues [nucleotide binding]
326424014981	TOBE domain; Region: TOBE_2; cl01440
326424014982	Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600
326424014983	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
326424014984	DNA binding residues [nucleotide binding]
326424014985	Dyp-type peroxidase family; Region: Dyp_perox; cl01067
326424014986	Frankia paralogous domain; Region: Frankia_40_dom; TIGR03917
326424014987	Phosphopantetheine attachment site; Region: PP-binding; cl09936
326424014988	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
326424014989	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
326424014990	P-loop; other site
326424014991	Magnesium ion binding site [ion binding]; other site
326424014992	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
326424014993	Magnesium ion binding site [ion binding]; other site
326424014994	mycothiol-dependent maleylpyruvate isomerase; Reviewed; Region: PRK09583
326424014995	Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; cl00986
326424014996	ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842
326424014997	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
326424014998	Walker A/P-loop; other site
326424014999	ATP binding site [chemical binding]; other site
326424015000	Q-loop/lid; other site
326424015001	ABC transporter signature motif; other site
326424015002	Walker B; other site
326424015003	D-loop; other site
326424015004	H-loop/switch region; other site
326424015005	Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687
326424015006	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
326424015007	ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177
326424015008	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
326424015009	dimer interface [polypeptide binding]; other site
326424015010	conserved gate region; other site
326424015011	putative PBP binding loops; other site
326424015012	ABC-ATPase subunit interface; other site
326424015013	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
326424015014	dimer interface [polypeptide binding]; other site
326424015015	conserved gate region; other site
326424015016	putative PBP binding loops; other site
326424015017	ABC-ATPase subunit interface; other site
326424015018	RF-1 domain; Region: RF-1; cl02875
326424015019	Restriction endonuclease; Region: Mrr_cat; cl00516
326424015020	Glutamate-cysteine ligase family 2(GCS2); Region: GCS2; cl00954
326424015021	TIGR03440 family protein; Region: unchr_TIGR03440
326424015022	Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; cl15394
326424015023	TIGR03442 family protein; Region: TIGR03442
326424015024	Glutamine amidotransferases class-II (Gn-AT)_YafJ-type.  YafJ is a glutamine amidotransferase-like protein of unknown function found in prokaryotes, eukaryotes and archaea.  YafJ has a conserved structural fold similar to those of other class II...; Region: YafJ; cd01908
326424015025	putative active site [active]
326424015026	putative dimer interface [polypeptide binding]; other site
326424015027	probable methyltransferase; Region: TIGR03438
326424015028	Uncharacterized conserved protein (DUF2260); Region: DUF2260; pfam10017
326424015029	Dehydratase family; Region: ILVD_EDD; cl00340
326424015030	Antibiotic biosynthesis monooxygenase; Region: ABM; cl10022
326424015031	DnaB-like helicase N terminal domain; Region: DnaB; pfam00772
326424015032	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
326424015033	Walker A motif; other site
326424015034	DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the  chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984
326424015035	ATP binding site [chemical binding]; other site
326424015036	Walker B motif; other site
326424015037	DNA binding loops [nucleotide binding]
326424015038	50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137
326424015039	Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281
326424015040	Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948
326424015041	Ribosomal protein S18; Region: Ribosomal_S18; cl00373
326424015042	SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496
326424015043	dimer interface [polypeptide binding]; other site
326424015044	ssDNA binding site [nucleotide binding]; other site
326424015045	tetramer (dimer of dimers) interface [polypeptide binding]; other site
326424015046	Ribosomal protein S6; Region: Ribosomal_S6; cl00414
326424015047	Protein of unknown function (DUF2029); Region: DUF2029; cl09812
326424015048	EBNA-3B; Provisional; Region: PHA03378
326424015049	Transglycosylase; Region: Transgly; cl07896
326424015050	penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074
326424015051	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009
326424015052	Helix-turn-helix domains; Region: HTH; cl00088
326424015053	Myo-inositol-1-phosphate synthase; Region: NAD_binding_5; cl00554
326424015054	H+ Antiporter protein; Region: 2A0121; TIGR00900
326424015055	tRNA adenylyltransferase; Region: tRNA_CCA_actino; TIGR02692
326424015056	Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398
326424015057	active site
326424015058	NTP binding site [chemical binding]; other site
326424015059	metal binding triad [ion binding]; metal-binding site
326424015060	Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627
326424015061	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
326424015062	Zn2+ binding site [ion binding]; other site
326424015063	Mg2+ binding site [ion binding]; other site
326424015064	Diadenosine hexaphosphate (Ap6A) hydrolase is a member of the Nudix hydrolase superfamily. Ap6A hydrolase specifically hydrolyzes diadenosine polyphosphates, but not ATP or diadenosine triphosphate, and it generates ATP as the product. Ap6A, the most...; Region: Ap6A_hydrolase; cd03673
326424015065	active site
326424015066	Ap6A binding site [chemical binding]; other site
326424015067	nudix motif; other site
326424015068	metal binding site [ion binding]; metal-binding site
326424015069	integral membrane protein MviN; Region: mviN; TIGR01695
326424015070	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
326424015071	active site
326424015072	ATP binding site [chemical binding]; other site
326424015073	NADPH-dependent FMN reductase; Region: FMN_red; cl00438
326424015074	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761
326424015075	thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292
326424015076	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
326424015077	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
326424015078	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
326424015079	catalytic residues [active]
326424015080	Putative peptidoglycan binding domain; Region: PG_binding_1; cl15437
326424015081	Putative peptidoglycan binding domain; Region: PG_binding_1; cl15437
326424015082	N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696
326424015083	active site
326424015084	metal binding site [ion binding]; metal-binding site
326424015085	ParB-like partition proteins; Region: parB_part; TIGR00180
326424015086	ParB-like nuclease domain; Region: ParBc; cl02129
326424015087	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
326424015088	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
326424015089	Magnesium ion binding site [ion binding]; other site
326424015090	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl15754
326424015091	jag_K homology RNA-binding domain. The KH domain is found in proteins homologous to the Bacillus subtilis protein Jag, which is associated with SpoIIIJ and is necessary for the third stage of sporulation.  The KH motif is a beta-alpha-alpha-beta-beta...; Region: jag_KH; cd02414
326424015092	G-X-X-G motif; other site
326424015093	R3H domain found in proteins homologous to Bacillus subtilus Jag, which is associated with SpoIIIJ. SpoIIIJ is necessary for the third stage of sporulation. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine...; Region: R3H_jag; cd02644
326424015094	RxxxH motif; other site
326424015095	60Kd inner membrane protein; Region: 60KD_IMP; cl00489
326424015096	Haemolytic domain; Region: Haemolytic; cl00506