-- dump date 20120504_145100 -- class Genbank::misc_feature -- table misc_feature_note -- id note 691437000001 chromosomal replication initiation protein; Reviewed; Region: dnaA; PRK00149 691437000002 DnaA N-terminal domain; Region: DnaA_N; pfam11638 691437000003 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 691437000004 Walker A motif; other site 691437000005 ATP binding site [chemical binding]; other site 691437000006 Walker B motif; other site 691437000007 arginine finger; other site 691437000008 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 691437000009 DnaA box-binding interface [nucleotide binding]; other site 691437000010 DNA polymerase III subunit beta; Validated; Region: PRK05643 691437000011 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 691437000012 putative DNA binding surface [nucleotide binding]; other site 691437000013 dimer interface [polypeptide binding]; other site 691437000014 beta-clamp/clamp loader binding surface; other site 691437000015 beta-clamp/translesion DNA polymerase binding surface; other site 691437000016 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cl09940 691437000017 recombination protein F; Reviewed; Region: recF; PRK00064 691437000018 RecF is a recombinational DNA repair ATPase that maintains replication in the presence of DNA damage. When replication is prematurely disrupted by DNA damage, several recF pathway gene products play critical roles processing the arrested replication...; Region: ABC_RecF; cd03242 691437000019 Walker A/P-loop; other site 691437000020 ATP binding site [chemical binding]; other site 691437000021 Q-loop/lid; other site 691437000022 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 691437000023 ABC transporter signature motif; other site 691437000024 Walker B; other site 691437000025 D-loop; other site 691437000026 H-loop/switch region; other site 691437000027 DNA gyrase subunit B; Validated; Region: gyrB; PRK05644 691437000028 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 691437000029 Mg2+ binding site [ion binding]; other site 691437000030 G-X-G motif; other site 691437000031 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 691437000032 anchoring element; other site 691437000033 dimer interface [polypeptide binding]; other site 691437000034 ATP binding site [chemical binding]; other site 691437000035 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 691437000036 active site 691437000037 putative metal-binding site [ion binding]; other site 691437000038 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 691437000039 DNA gyrase subunit A; Validated; Region: PRK05560 691437000040 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes in DNA...; Region: TOP4c; cd00187 691437000041 CAP-like domain; other site 691437000042 active site 691437000043 primary dimer interface [polypeptide binding]; other site 691437000044 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 691437000045 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 691437000046 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 691437000047 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 691437000048 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 691437000049 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 691437000050 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 691437000051 Zn2+ binding site [ion binding]; other site 691437000052 Mg2+ binding site [ion binding]; other site 691437000053 YaaC-like Protein; Region: YaaC; pfam14175 691437000054 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 691437000055 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl09108 691437000056 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a key...; Region: CBS_pair_IMPDH; cd04601 691437000057 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of the guanine...; Region: IMPDH; cd00381 691437000058 active site 691437000059 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 691437000060 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 691437000061 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; cl06814 691437000062 pyridoxal 5'-phosphate synthase, synthase subunit Pdx1; Region: TIGR00343 691437000063 PdxS is a subunit of the pyridoxal 5'-phosphate (PLP) synthase, an important enzyme in deoxyxylulose 5-phosphate (DXP)-independent pathway for de novo biosynthesis of PLP, present in some eubacteria, in archaea, fungi, plants, plasmodia, and some...; Region: pdxS; cd04727 691437000064 active site 691437000065 multimer interface [polypeptide binding]; other site 691437000066 Glutamine amidotransferase [Amino acid transport and metabolism]; Region: HisH; COG0118 691437000067 Glutamine Amidotransferase (GATase_I) involved in pyridoxine biosynthesis; Region: GATase1_PB; cd01749 691437000068 predicted active site [active] 691437000069 catalytic triad [active] 691437000070 seryl-tRNA synthetase; Provisional; Region: PRK05431 691437000071 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 691437000072 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme bound...; Region: SerRS_core; cd00770 691437000073 dimer interface [polypeptide binding]; other site 691437000074 active site 691437000075 motif 1; other site 691437000076 motif 2; other site 691437000077 motif 3; other site 691437000078 Predicted glycosyl hydrolase [General function prediction only]; Region: COG3858 691437000079 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118 691437000080 putative peptidoglycan binding site; other site 691437000081 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118 691437000082 putative peptidoglycan binding site; other site 691437000083 Cortical fragment-lytic enzyme (CFLE) is a peptidoglycan hydrolase involved in bacterial endospore germination. CFLE is expressed as an inactive preprotein (called SleB) in the forespore compartment of sporulating cells. SleB translocates across the...; Region: GH18_CFLE_spore_hydrolase; cd02874 691437000084 active site 691437000085 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 691437000086 nucleoside/Zn binding site; other site 691437000087 dimer interface [polypeptide binding]; other site 691437000088 catalytic motif [active] 691437000089 DNA polymerase III subunits gamma and tau; Validated; Region: PRK05563 691437000090 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 691437000091 Walker A motif; other site 691437000092 ATP binding site [chemical binding]; other site 691437000093 Walker B motif; other site 691437000094 arginine finger; other site 691437000095 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 691437000096 YbaB/EbfC DNA-binding family; Region: YbaB_DNA_bd; cl00494 691437000097 recombination protein RecR; Reviewed; Region: recR; PRK00076 691437000098 RecR protein; Region: RecR; pfam02132 691437000099 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 691437000100 putative active site [active] 691437000101 putative metal-binding site [ion binding]; other site 691437000102 tetramer interface [polypeptide binding]; other site 691437000103 Protein of unknown function (DUF2508); Region: DUF2508; pfam10704 691437000104 SigmaK-factor processing regulatory protein BofA; Region: BofA; cl06466 691437000105 Inhibitor of sigma-G Gin; Region: Gin; pfam10764 691437000106 Arginine/lysine/ornithine decarboxylases [Amino acid transport and metabolism]; Region: LdcC; COG1982 691437000107 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 691437000108 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 691437000109 catalytic residue [active] 691437000110 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 691437000111 thymidylate kinase; Validated; Region: tmk; PRK00698 691437000112 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 691437000113 TMP-binding site; other site 691437000114 ATP-binding site [chemical binding]; other site 691437000115 DNA polymerase III subunit delta'; Validated; Region: PRK08058 691437000116 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 691437000117 PSP1 C-terminal conserved region; Region: PSP1; cl00770 691437000118 TSC-22/dip/bun family; Region: TSC22; cl01853 691437000119 Predicted O-methyltransferase [General function prediction only]; Region: COG4123 691437000120 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 691437000121 S-adenosylmethionine binding site [chemical binding]; other site 691437000122 Predicted methyltransferases [General function prediction only]; Region: COG0313 691437000123 Precorrin-3B methylase [Coenzyme metabolism]; Region: CobJ; cl00304 691437000124 stage V sporulation protein T; Region: spore_V_T; TIGR02851 691437000125 Antidote-toxin recognition MazE; Region: Antitoxin-MazE; cl00877 691437000126 methionyl-tRNA synthetase; Reviewed; Region: PRK12267 691437000127 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 691437000128 active site 691437000129 HIGH motif; other site 691437000130 KMSKS motif; other site 691437000131 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 691437000132 tRNA binding surface [nucleotide binding]; other site 691437000133 anticodon binding site; other site 691437000134 tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins. This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties. MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800 691437000135 dimer interface [polypeptide binding]; other site 691437000136 putative tRNA-binding site [nucleotide binding]; other site 691437000137 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 691437000138 active site 691437000139 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3583 691437000140 Domain of unknown function (DUF348); Region: DUF348; pfam03990 691437000141 Domain of unknown function (DUF348); Region: DUF348; pfam03990 691437000142 Domain of unknown function (DUF348); Region: DUF348; pfam03990 691437000143 G5 domain; Region: G5; pfam07501 691437000144 3D domain; Region: 3D; cl01439 691437000145 ribonuclease M5; Region: 5S_RNA_mat_M5; TIGR00334 691437000146 TOPRIM_ RNase M5_like: The topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain found in Ribonuclease M5: (RNase M5) and other small primase-like proteins from bacteria and archaea. RNase M5 catalyzes the maturation of 5S rRNA in low...; Region: TOPRIM_RNase_M5_like; cd01027 691437000147 putative active site [active] 691437000148 putative metal binding site [ion binding]; other site 691437000149 Domain of unknown function (DUF4093); Region: DUF4093; pfam13331 691437000150 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 691437000151 YabG peptidase U57; Region: Peptidase_U57; cl05250 691437000152 Protein of unknown function (DUF1021); Region: DUF1021; cl01852 691437000153 Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269 691437000154 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: ipk; PRK00128 691437000155 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 691437000156 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 691437000157 pur operon repressor; Provisional; Region: PRK09213 691437000158 Bacterial purine repressor, N-terminal; Region: PuR_N; pfam09182 691437000159 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 691437000160 active site 691437000161 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 691437000162 homotrimer interaction site [polypeptide binding]; other site 691437000163 putative active site [active] 691437000164 SpoVG; Region: SpoVG; cl00915 691437000165 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14354 691437000166 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 691437000167 Substrate binding site; other site 691437000168 Mg++ binding site; other site 691437000169 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 691437000170 active site 691437000171 substrate binding site [chemical binding]; other site 691437000172 CoA binding site [chemical binding]; other site 691437000173 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259 691437000174 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 691437000175 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 691437000176 active site 691437000177 50S ribosomal protein L25/general stress protein Ctc; Reviewed; Region: PRK05618 691437000178 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 691437000179 5S rRNA interface [nucleotide binding]; other site 691437000180 CTC domain interface [polypeptide binding]; other site 691437000181 L16 interface [polypeptide binding]; other site 691437000182 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 691437000183 putative active site [active] 691437000184 catalytic residue [active] 691437000185 Protein of unknown function (DUF2757); Region: DUF2757; pfam10955 691437000186 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 691437000187 CarD-like/TRCF domain; Region: CarD_CdnL_TRCF; cl00588 691437000188 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 691437000189 ATP binding site [chemical binding]; other site 691437000190 putative Mg++ binding site [ion binding]; other site 691437000191 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 691437000192 nucleotide binding region [chemical binding]; other site 691437000193 ATP-binding site [chemical binding]; other site 691437000194 TRCF domain; Region: TRCF; cl04088 691437000195 stage V sporulation protein T; Region: spore_V_T; TIGR02851 691437000196 Antidote-toxin recognition MazE; Region: Antitoxin-MazE; cl00877 691437000197 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 691437000198 MatE; Region: MatE; cl10513 691437000199 Protein containing tetrapyrrole methyltransferase domain and MazG-like (predicted pyrophosphatase) domain [General function prediction only]; Region: COG3956 691437000200 Precorrin-3B methylase [Coenzyme metabolism]; Region: CobJ; cl00304 691437000201 Precorrin-3B methylase [Coenzyme metabolism]; Region: CobJ; cl00304 691437000202 MazG nucleotide pyrophosphohydrolase domain; Region: MazG; cl00345 691437000203 MazG nucleotide pyrophosphohydrolase domain; Region: MazG; cl00345 691437000204 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 691437000205 RNA binding surface [nucleotide binding]; other site 691437000206 YabP family; Region: YabP; cl06766 691437000207 Spore cortex protein YabQ (Spore_YabQ); Region: Spore_YabQ; cl09801 691437000208 Septum formation initiator; Region: DivIC; cl11433 691437000209 hypothetical protein; Provisional; Region: PRK08582 691437000210 S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists of...; Region: S1_RPS1_repeat_hs4; cd05692 691437000211 RNA binding site [nucleotide binding]; other site 691437000212 stage II sporulation protein E; Region: spore_II_E; TIGR02865 691437000213 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl15769 691437000214 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cl00120 691437000215 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 691437000216 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 691437000217 metal ion-dependent adhesion site (MIDAS); other site 691437000218 Catalytic domain of Protein Kinases; Region: PKc; cd00180 691437000219 active site 691437000220 ATP binding site [chemical binding]; other site 691437000221 substrate binding site [chemical binding]; other site 691437000222 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 691437000223 active site 691437000224 ATP binding site [chemical binding]; other site 691437000225 substrate binding site [chemical binding]; other site 691437000226 activation loop (A-loop); other site 691437000227 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 691437000228 Ligand Binding Site [chemical binding]; other site 691437000229 B3/4 domain; Region: B3_4; cl11458 691437000230 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 691437000231 active site 691437000232 FtsH Extracellular; Region: FtsH_ext; pfam06480 691437000233 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 691437000234 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 691437000235 Walker A motif; other site 691437000236 ATP binding site [chemical binding]; other site 691437000237 Walker B motif; other site 691437000238 arginine finger; other site 691437000239 Peptidase family M41; Region: Peptidase_M41; pfam01434 691437000240 Type III pantothenate kinase; Region: Pan_kinase; cl09130 691437000241 Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114 691437000242 Heat shock protein 33 (Hsp33): Cytosolic protein that acts as a molecular chaperone under oxidative conditions. In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498 691437000243 dimerization interface [polypeptide binding]; other site 691437000244 domain crossover interface; other site 691437000245 redox-dependent activation switch; other site 691437000246 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 691437000247 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 691437000248 dimer interface [polypeptide binding]; other site 691437000249 pyridoxal 5'-phosphate binding site [chemical binding]; other site 691437000250 catalytic residue [active] 691437000251 anthranilate synthase component I, non-proteobacterial lineages; Region: trpE_most; TIGR00564 691437000252 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 691437000253 chorismate binding enzyme; Region: Chorismate_bind; cl10555 691437000254 para-aminobenzoate synthase component II; Provisional; Region: PRK08857 691437000255 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 691437000256 glutamine binding [chemical binding]; other site 691437000257 catalytic triad [active] 691437000258 PyridoxaL 5'-Phosphate Dependent Enzymes class IV (PLPDE_IV). This D-amino acid superfamily, one of five classes of PLPDE, consists of branched-chain amino acid aminotransferases (BCAT), D-amino acid transferases (DAAT), and 4-amino-4-deoxychorismate...; Region: PLPDE_IV; cl00224 691437000259 homodimer interface [polypeptide binding]; other site 691437000260 substrate-cofactor binding pocket; other site 691437000261 pyridoxal 5'-phosphate binding site [chemical binding]; other site 691437000262 catalytic residue [active] 691437000263 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 691437000264 dihydropteroate synthase; Region: DHPS; TIGR01496 691437000265 substrate binding pocket [chemical binding]; other site 691437000266 dimer interface [polypeptide binding]; other site 691437000267 inhibitor binding site; inhibition site 691437000268 Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534 691437000269 homooctamer interface [polypeptide binding]; other site 691437000270 active site 691437000271 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 691437000272 catalytic center binding site [active] 691437000273 ATP binding site [chemical binding]; other site 691437000274 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 691437000275 non-specific DNA binding site [nucleotide binding]; other site 691437000276 salt bridge; other site 691437000277 sequence-specific DNA binding site [nucleotide binding]; other site 691437000278 putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737 691437000279 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 691437000280 FMN binding site [chemical binding]; other site 691437000281 active site 691437000282 catalytic residues [active] 691437000283 substrate binding site [chemical binding]; other site 691437000284 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 691437000285 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 691437000286 dimer interface [polypeptide binding]; other site 691437000287 putative anticodon binding site; other site 691437000288 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 691437000289 motif 1; other site 691437000290 active site 691437000291 motif 2; other site 691437000292 motif 3; other site 691437000293 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 691437000294 putative trimer interface [polypeptide binding]; other site 691437000295 putative CoA binding site [chemical binding]; other site 691437000296 Firmicute transcriptional repressor of class III stress genes (CtsR); Region: CtsR; cl01850 691437000297 Modulator of heat shock repressor CtsR, McsA [Signal transduction mechanisms]; Region: COG3880 691437000298 ATP:guanido phosphotransferase; Provisional; Region: PRK01059 691437000299 Phosphagen (guanidino) kinases found in bacteria; Region: bacterial_phosphagen_kinase; cd07930 691437000300 ADP binding site [chemical binding]; other site 691437000301 phosphagen binding site; other site 691437000302 substrate specificity loop; other site 691437000303 Clp protease ATP binding subunit; Region: clpC; CHL00095 691437000304 Clp amino terminal domain; Region: Clp_N; pfam02861 691437000305 Clp amino terminal domain; Region: Clp_N; pfam02861 691437000306 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 691437000307 Walker A motif; other site 691437000308 ATP binding site [chemical binding]; other site 691437000309 Walker B motif; other site 691437000310 arginine finger; other site 691437000311 UvrB/uvrC motif; Region: UVR; pfam02151 691437000312 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 691437000313 Walker A motif; other site 691437000314 ATP binding site [chemical binding]; other site 691437000315 Walker B motif; other site 691437000316 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; cl11083 691437000317 DNA repair protein RadA; Provisional; Region: PRK11823 691437000318 Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121 691437000319 Walker A motif/ATP binding site; other site 691437000320 ATP binding site [chemical binding]; other site 691437000321 Walker B motif; other site 691437000322 Subunit ChlI of Mg-chelatase; Region: ChlI; cl12214 691437000323 Integral membrane protein (PIN domain superfamily) [General function prediction only]; Region: COG4956 691437000324 PIN domain of Thermus Thermophilus Hb8, uncharacterized Bacillus subtilis YacL, and other bacterial homologs; Region: PIN_YacL; cd09877 691437000325 putative active site [active] 691437000326 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 691437000327 substrate binding site; other site 691437000328 dimer interface; other site 691437000329 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554 691437000330 homotrimer interaction site [polypeptide binding]; other site 691437000331 zinc binding site [ion binding]; other site 691437000332 CDP-binding sites; other site 691437000333 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 691437000334 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 691437000335 HIGH motif; other site 691437000336 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 691437000337 active site 691437000338 KMSKS motif; other site 691437000339 serine O-acetyltransferase; Region: cysE; TIGR01172 691437000340 Serine acetyltransferase, N-terminal; Region: SATase_N; cl05762 691437000341 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 691437000342 trimer interface [polypeptide binding]; other site 691437000343 active site 691437000344 substrate binding site [chemical binding]; other site 691437000345 CoA binding site [chemical binding]; other site 691437000346 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 691437000347 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 691437000348 active site 691437000349 HIGH motif; other site 691437000350 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 691437000351 KMSKS motif; other site 691437000352 Anticodon-binding domain of cysteinyl tRNA synthetases; Region: Anticodon_Ia_Cys; cd07963 691437000353 tRNA binding surface [nucleotide binding]; other site 691437000354 anticodon binding site; other site 691437000355 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 691437000356 dimerization interface [polypeptide binding]; other site 691437000357 active site 691437000358 metal binding site [ion binding]; metal-binding site 691437000359 rRNA methylase, putative, group 3; Region: rRNA_methyl_3; TIGR00186 691437000360 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; cl06870 691437000361 SpoU rRNA Methylase family; Region: SpoU_methylase; cl00362 691437000362 YacP-like NYN domain; Region: NYN_YacP; cl01491 691437000363 RNA polymerase factor sigma-70; Validated; Region: PRK08295 691437000364 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 691437000365 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 691437000366 Ribosomal protein L33; Region: Ribosomal_L33; cl00383 691437000367 SecE/Sec61-gamma subunits of protein translocation complex; Region: SecE; cl00481 691437000368 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 691437000369 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 691437000370 putative homodimer interface [polypeptide binding]; other site 691437000371 KOW motif; Region: KOW; cl00354 691437000372 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 691437000373 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 691437000374 23S rRNA interface [nucleotide binding]; other site 691437000375 L7/L12 interface [polypeptide binding]; other site 691437000376 putative thiostrepton binding site; other site 691437000377 L25 interface [polypeptide binding]; other site 691437000378 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 691437000379 mRNA/rRNA interface [nucleotide binding]; other site 691437000380 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 691437000381 23S rRNA interface [nucleotide binding]; other site 691437000382 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 691437000383 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 691437000384 core dimer interface [polypeptide binding]; other site 691437000385 peripheral dimer interface [polypeptide binding]; other site 691437000386 L10 interface [polypeptide binding]; other site 691437000387 L11 interface [polypeptide binding]; other site 691437000388 putative EF-Tu interaction site [polypeptide binding]; other site 691437000389 putative EF-G interaction site [polypeptide binding]; other site 691437000390 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 691437000391 S-adenosylmethionine binding site [chemical binding]; other site 691437000392 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 691437000393 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl04593 691437000394 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 691437000395 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 691437000396 RPB1 interaction site [polypeptide binding]; other site 691437000397 RPB10 interaction site [polypeptide binding]; other site 691437000398 RPB11 interaction site [polypeptide binding]; other site 691437000399 RPB3 interaction site [polypeptide binding]; other site 691437000400 RPB12 interaction site [polypeptide binding]; other site 691437000401 DNA-directed RNA polymerase subunit beta'; Provisional; Region: PRK00566 691437000402 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 691437000403 RNA polymerase Rpb1, domain 2; Region: RNA_pol_Rpb1_2; cl11591 691437000404 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 691437000405 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 691437000406 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 691437000407 Rpb1 (beta') - Rpb6 (omega) interaction site [polypeptide binding]; other site 691437000408 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 691437000409 G-loop; other site 691437000410 DNA binding site [nucleotide binding] 691437000411 Ribosomal protein L7Ae/L30e/S12e/Gadd45 family; Region: Ribosomal_L7Ae; cl00600 691437000412 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 691437000413 S17 interaction site [polypeptide binding]; other site 691437000414 S8 interaction site; other site 691437000415 16S rRNA interaction site [nucleotide binding]; other site 691437000416 streptomycin interaction site [chemical binding]; other site 691437000417 23S rRNA interaction site [nucleotide binding]; other site 691437000418 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 691437000419 Ribosomal protein S7p/S5e; Region: Ribosomal_S7; cl00313 691437000420 elongation factor G; Reviewed; Region: PRK00007 691437000421 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 691437000422 G1 box; other site 691437000423 putative GEF interaction site [polypeptide binding]; other site 691437000424 GTP/Mg2+ binding site [chemical binding]; other site 691437000425 Switch I region; other site 691437000426 G2 box; other site 691437000427 G3 box; other site 691437000428 Switch II region; other site 691437000429 G4 box; other site 691437000430 G5 box; other site 691437000431 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 691437000432 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 691437000433 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 691437000434 elongation factor Tu; Reviewed; Region: PRK00049 691437000435 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 691437000436 G1 box; other site 691437000437 GEF interaction site [polypeptide binding]; other site 691437000438 GTP/Mg2+ binding site [chemical binding]; other site 691437000439 Switch I region; other site 691437000440 G2 box; other site 691437000441 G3 box; other site 691437000442 Switch II region; other site 691437000443 G4 box; other site 691437000444 G5 box; other site 691437000445 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 691437000446 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 691437000447 Antibiotic Binding Site [chemical binding]; other site 691437000448 Ribosomal protein S10p/S20e; Region: Ribosomal_S10; cl00314 691437000449 Ribosomal protein L3; Region: Ribosomal_L3; cl00324 691437000450 Ribosomal protein L4/L1 family; Region: Ribosomal_L4; cl00325 691437000451 Ribosomal protein L23; Region: Ribosomal_L23; cl00326 691437000452 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 691437000453 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 691437000454 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 691437000455 Ribosomal protein S19; Region: Ribosomal_S19; cl00350 691437000456 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 691437000457 putative translocon binding site; other site 691437000458 protein-rRNA interface [nucleotide binding]; other site 691437000459 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 691437000460 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 691437000461 G-X-X-G motif; other site 691437000462 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 691437000463 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 691437000464 23S rRNA interface [nucleotide binding]; other site 691437000465 5S rRNA interface [nucleotide binding]; other site 691437000466 putative antibiotic binding site [chemical binding]; other site 691437000467 L25 interface [polypeptide binding]; other site 691437000468 L27 interface [polypeptide binding]; other site 691437000469 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 691437000470 23S rRNA interface [nucleotide binding]; other site 691437000471 putative translocon interaction site; other site 691437000472 signal recognition particle (SRP54) interaction site; other site 691437000473 L23 interface [polypeptide binding]; other site 691437000474 trigger factor interaction site; other site 691437000475 Ribosomal protein S17; Region: Ribosomal_S17; cl00351 691437000476 Ribosomal protein L14p/L23e; Region: Ribosomal_L14; cl00328 691437000477 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 691437000478 KOW motif; Region: KOW; cl00354 691437000479 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 691437000480 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 691437000481 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 691437000482 Ribosomal protein S14p/S29e; Region: Ribosomal_S14; cl00355 691437000483 Ribosomal protein S8; Region: Ribosomal_S8; cl00330 691437000484 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 691437000485 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 691437000486 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 691437000487 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 691437000488 5S rRNA interface [nucleotide binding]; other site 691437000489 L27 interface [polypeptide binding]; other site 691437000490 23S rRNA interface [nucleotide binding]; other site 691437000491 L5 interface [polypeptide binding]; other site 691437000492 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 691437000493 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 691437000494 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 691437000495 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 691437000496 23S rRNA binding site [nucleotide binding]; other site 691437000497 Ribosomal protein L18e/L15; Region: Ribosomal_L18e; cl12022 691437000498 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 691437000499 SecY translocase; Region: SecY; pfam00344 691437000500 adenylate kinase; Reviewed; Region: adk; PRK00279 691437000501 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 691437000502 AMP-binding site [chemical binding]; other site 691437000503 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 691437000504 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 691437000505 active site 691437000506 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 691437000507 rRNA binding site [nucleotide binding]; other site 691437000508 predicted 30S ribosome binding site; other site 691437000509 Ribosomal protein L36; Region: Ribosomal_L36; cl00380 691437000510 Ribosomal protein S13/S18; Region: Ribosomal_S13; cl00331 691437000511 Ribosomal protein S13 [Translation, ribosomal structure and biogenesis]; Region: RpsM; COG0099 691437000512 Ribosomal protein S11; Region: Ribosomal_S11; cl00332 691437000513 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 691437000514 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 691437000515 alphaNTD - beta interaction site [polypeptide binding]; other site 691437000516 alphaNTD homodimer interface [polypeptide binding]; other site 691437000517 alphaNTD - beta' interaction site [polypeptide binding]; other site 691437000518 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; cl11613 691437000519 Ribosomal protein L17; Region: Ribosomal_L17; cl00356 691437000520 cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13635 691437000521 Domain I of the ABC component of a cobalt transport family found in bacteria, archaea, and eukaryota. The transition metal cobalt is an essential component of many enzymes and must be transported into cells in appropriate amounts when needed. This ABC...; Region: ABC_cobalt_CbiO_domain1; cd03225 691437000522 Walker A/P-loop; other site 691437000523 ATP binding site [chemical binding]; other site 691437000524 Q-loop/lid; other site 691437000525 ABC transporter signature motif; other site 691437000526 Walker B; other site 691437000527 D-loop; other site 691437000528 H-loop/switch region; other site 691437000529 cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13634 691437000530 Domain I of the ABC component of a cobalt transport family found in bacteria, archaea, and eukaryota. The transition metal cobalt is an essential component of many enzymes and must be transported into cells in appropriate amounts when needed. This ABC...; Region: ABC_cobalt_CbiO_domain1; cd03225 691437000531 Walker A/P-loop; other site 691437000532 ATP binding site [chemical binding]; other site 691437000533 Q-loop/lid; other site 691437000534 ABC transporter signature motif; other site 691437000535 Walker B; other site 691437000536 D-loop; other site 691437000537 H-loop/switch region; other site 691437000538 Cobalt transport protein; Region: CbiQ; cl00463 691437000539 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 691437000540 PseudoU_synth_EcTruA: Pseudouridine synthase, Escherichia coli TruA like. This group consists of eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA, Pseudomonas aeruginosa truA and human pseudouridine synthase-like 1 (PUSL1); Region: PseudoU_synth_EcTruA; cd02570 691437000541 dimerization interface 3.5A [polypeptide binding]; other site 691437000542 active site 691437000543 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 691437000544 23S rRNA interface [nucleotide binding]; other site 691437000545 L3 interface [polypeptide binding]; other site 691437000546 Ribosomal protein S9/S16; Region: Ribosomal_S9; cl00334 691437000547 Protein of unknown function (DUF2521); Region: DUF2521; pfam10730 691437000548 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 691437000549 active site 691437000550 Domain of unknown function DUF59; Region: DUF59; cl00941 691437000551 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 691437000552 Walker A motif; other site 691437000553 KinB-signalling pathway activation in sporulation; Region: KbaA; pfam14089 691437000554 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 691437000555 Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692 691437000556 Arginase family; Region: Arginase; cl00306 691437000557 RNA polymerase sigma factor SigW; Provisional; Region: PRK09641 691437000558 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 691437000559 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 691437000560 DNA binding residues [nucleotide binding] 691437000561 Predicted transmembrane transcriptional regulator (anti-sigma factor) [Transcription]; Region: COG5662 691437000562 Putative zinc-finger; Region: zf-HC2; cl15806 691437000563 Uncharacterized conserved protein [Function unknown]; Region: COG1624 691437000564 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 691437000565 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4856 691437000566 YbbR-like protein; Region: YbbR; pfam07949 691437000567 YbbR-like protein; Region: YbbR; pfam07949 691437000568 YbbR-like protein; Region: YbbR; pfam07949 691437000569 phosphoglucosamine mutase; Provisional; Region: glmM; PRK14316 691437000570 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 691437000571 active site 691437000572 substrate binding site [chemical binding]; other site 691437000573 metal binding site [ion binding]; metal-binding site 691437000574 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 691437000575 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 691437000576 glutaminase active site [active] 691437000577 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 691437000578 dimer interface [polypeptide binding]; other site 691437000579 active site 691437000580 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 691437000581 dimer interface [polypeptide binding]; other site 691437000582 active site 691437000583 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 691437000584 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 691437000585 dimer interface [polypeptide binding]; other site 691437000586 conserved gate region; other site 691437000587 ABC-ATPase subunit interface; other site 691437000588 uridine kinase; Validated; Region: PRK06696 691437000589 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 691437000590 active site 691437000591 Protein of unknown function (DUF3036); Region: DUF3036; pfam11234 691437000592 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 691437000593 Protein of unknown function (DUF817); Region: DUF817; cl01520 691437000594 DinB superfamily; Region: DinB_2; pfam12867 691437000595 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; cl00986 691437000596 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 691437000597 active site 691437000598 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 691437000599 PAS fold; Region: PAS; pfam00989 691437000600 psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974 691437000601 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 691437000602 Walker A motif; other site 691437000603 ATP binding site [chemical binding]; other site 691437000604 Walker B motif; other site 691437000605 arginine finger; other site 691437000606 Helix-turn-helix domains; Region: HTH; cl00088 691437000607 Amino acid transporters [Amino acid transport and metabolism]; Region: LysP; COG0833 691437000608 1-pyrroline-5-carboxylate dehydrogenase; Provisional; Region: PRK03137 691437000609 Delta(1)-pyrroline-5-carboxylate dehydrogenase, RocA; Region: ALDH_PutA-P5CDH-RocA; cd07124 691437000610 Glutamate binding site [chemical binding]; other site 691437000611 homodimer interface [polypeptide binding]; other site 691437000612 NAD binding site [chemical binding]; other site 691437000613 catalytic residues [active] 691437000614 ornithine--oxo-acid transaminase; Provisional; Region: rocD; PRK04073 691437000615 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 691437000616 inhibitor-cofactor binding pocket; inhibition site 691437000617 pyridoxal 5'-phosphate binding site [chemical binding]; other site 691437000618 catalytic residue [active] 691437000619 Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334 691437000620 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 691437000621 NAD(P) binding domain of glutamate dehydrogenase, subgroup 1; Region: NAD_bind_1_Glu_DH; cd01076 691437000622 NAD(P) binding site [chemical binding]; other site 691437000623 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 691437000624 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 691437000625 dimer interface [polypeptide binding]; other site 691437000626 putative PBP binding regions; other site 691437000627 ABC-ATPase subunit interface; other site 691437000628 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 691437000629 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 691437000630 ABC-ATPase subunit interface; other site 691437000631 dimer interface [polypeptide binding]; other site 691437000632 putative PBP binding regions; other site 691437000633 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 691437000634 Periplasmic binding protein FeuA. These proteins have predicted to function as initial receptors in ABC transport of metal ions in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct...; Region: FeuA; cd01138 691437000635 putative ligand binding residues [chemical binding]; other site 691437000636 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 691437000637 ABC transporters, involved in the uptake of siderophores, heme, and vitamin B12, are widely conserved in bacteria and archaea. Only very few species lack representatives of the siderophore family transporters. The E. coli BtuCD protein is an ABC...; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 691437000638 Walker A/P-loop; other site 691437000639 ATP binding site [chemical binding]; other site 691437000640 Q-loop/lid; other site 691437000641 ABC transporter signature motif; other site 691437000642 Walker B; other site 691437000643 D-loop; other site 691437000644 H-loop/switch region; other site 691437000645 FOG: CBS domain [General function prediction only]; Region: COG0517 691437000646 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205 691437000647 Transcriptional regulator containing PAS, AAA-type ATPase, and DNA-binding domains [Transcription / Signal transduction mechanisms]; Region: RocR; COG3829 691437000648 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 691437000649 putative active site [active] 691437000650 heme pocket [chemical binding]; other site 691437000651 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 691437000652 Walker A motif; other site 691437000653 ATP binding site [chemical binding]; other site 691437000654 Walker B motif; other site 691437000655 arginine finger; other site 691437000656 Helix-turn-helix domains; Region: HTH; cl00088 691437000657 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 691437000658 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 691437000659 active site 691437000660 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 691437000661 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 691437000662 NAD(P) binding site [chemical binding]; other site 691437000663 catalytic residues [active] 691437000664 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 691437000665 iron-containing alcohol dehydrogenases (Fe-ADH)-like; Region: Fe-ADH; cd08551 691437000666 active site 691437000667 metal binding site [ion binding]; metal-binding site 691437000668 DoxX; Region: DoxX; cl00976 691437000669 Predicted dithiol-disulfide isomerase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FrnE; COG2761 691437000670 DsbA family, FrnE subfamily; FrnE is a DsbA-like protein containing a CXXC motif. It is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the aromatic antibiotics frenolicin and nanaomycins; Region: DsbA_FrnE; cd03024 691437000671 catalytic residues [active] 691437000672 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; cl00986 691437000673 DinB superfamily; Region: DinB_2; pfam12867 691437000674 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 691437000675 Histidine kinase; Region: HisKA_3; pfam07730 691437000676 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 691437000677 daunorubicin resistance ABC transporter ATP-binding subunit; Region: drrA; TIGR01188 691437000678 Walker A/P-loop; other site 691437000679 ATP binding site [chemical binding]; other site 691437000680 Q-loop/lid; other site 691437000681 ABC transporter signature motif; other site 691437000682 Walker B; other site 691437000683 D-loop; other site 691437000684 H-loop/switch region; other site 691437000685 ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668 691437000686 ABC-2 type transporter; Region: ABC2_membrane; cl11417 691437000687 ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668 691437000688 ABC-2 type transporter; Region: ABC2_membrane; cl11417 691437000689 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 691437000690 active site 691437000691 metal binding site [ion binding]; metal-binding site 691437000692 Peptidase S8 family domain, uncharacterized subfamily 1; Region: Peptidases_S8_1; cd07487 691437000693 active site 691437000694 catalytic triad [active] 691437000695 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368 691437000696 Sulfatase; Region: Sulfatase; cl10460 691437000697 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 691437000698 Cation transport protein; Region: TrkH; cl10514 691437000699 Amino acid permease; Region: AA_permease_2; pfam13520 691437000700 putative sporulation protein YtaF; Region: spore_YtaF; TIGR02840 691437000701 Domain of unknown function DUF; Region: DUF204; pfam02659 691437000702 Sporulation control protein [General function prediction only]; Region: Spo0M; COG4326 691437000703 SpoOM protein; Region: Spo0M; pfam07070 691437000704 Coat F domain; Region: Coat_F; cl15836 691437000705 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 691437000706 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 691437000707 Bacitracin resistance protein BacA; Region: BacA; cl00858 691437000708 undecaprenyldiphospho-muramoylpentapeptide beta-N-acetylglucosaminyltransferase; Reviewed; Region: PRK12446 691437000709 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 691437000710 active site 691437000711 homodimer interface [polypeptide binding]; other site 691437000712 Catalytic NodB homology domain of uncharacterized bacterial polysaccharide deacetylases; Region: CE4_NodB_like_3; cd10959 691437000713 NodB motif; other site 691437000714 putative active site [active] 691437000715 putative catalytic site [active] 691437000716 putative Zn binding site [ion binding]; other site 691437000717 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 691437000718 UDP-N-acetylglucosamine:LPS N-acetylglucosamine transferase [Cell envelope biogenesis, outer membrane]; Region: MurG; COG0707 691437000719 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 691437000720 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 691437000721 D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966 691437000722 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 691437000723 ATP-grasp domain; Region: ATP-grasp_4; cl03087 691437000724 UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770 691437000725 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 691437000726 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 691437000727 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 691437000728 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 691437000729 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 691437000730 ATP binding site [chemical binding]; other site 691437000731 Mg++ binding site [ion binding]; other site 691437000732 motif III; other site 691437000733 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 691437000734 nucleotide binding region [chemical binding]; other site 691437000735 ATP-binding site [chemical binding]; other site 691437000736 Rhomboid family; Region: Rhomboid; cl11446 691437000737 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; cl00500 691437000738 Outer membrane lipoprotein carrier protein LolA; Region: LolA; cl01065 691437000739 alanine racemase; Reviewed; Region: alr; PRK00053 691437000740 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 691437000741 active site 691437000742 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 691437000743 dimer interface [polypeptide binding]; other site 691437000744 substrate binding site [chemical binding]; other site 691437000745 catalytic residues [active] 691437000746 Predicted transcriptional regulators containing the CopG/Arc/MetJ DNA-binding domain and a metal-binding domain [Transcription]; Region: NikR; COG0864 691437000747 PemK-like protein; Region: PemK; cl00995 691437000748 Transcriptional accessory protein [Transcription]; Region: Tex; COG2183 691437000749 Tex-like protein N-terminal domain; Region: Tex_N; pfam09371 691437000750 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD includes...; Region: RuvC_resolvase; cl00243 691437000751 S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685 691437000752 RNA binding site [nucleotide binding]; other site 691437000753 SprT homologues; Region: SprT; cl01182 691437000754 hypothetical protein; Provisional; Region: PRK04351 691437000755 Uncharacterized P-loop hydrolase UPF0079; Region: UPF0079; cl00520 691437000756 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl14000 691437000757 Glycoprotease family; Region: Peptidase_M22; pfam00814 691437000758 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 691437000759 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 691437000760 Coenzyme A binding pocket [chemical binding]; other site 691437000761 UGMP family protein; Validated; Region: PRK09604 691437000762 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl14000 691437000763 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 691437000764 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 691437000765 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 691437000766 ABC transporter; Region: ABC_tran_2; pfam12848 691437000767 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 691437000768 ABC transporter; Region: ABC_tran_2; pfam12848 691437000769 MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420 691437000770 trimer interface [polypeptide binding]; other site 691437000771 dimer interface [polypeptide binding]; other site 691437000772 putative active site [active] 691437000773 redox-sensing transcriptional repressor Rex; Provisional; Region: PRK05472 691437000774 Putative DNA-binding protein N-terminus; Region: Put_DNA-bind_N; pfam06971 691437000775 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 691437000776 mttA/Hcf106 family; Region: MttA_Hcf106; cl00788 691437000777 Sec-independent protein translocase protein (TatC); Region: TatC; cl00521 691437000778 Domain of unknown function (DUF4305); Region: DUF4305; pfam14146 691437000779 CAAX protease self-immunity; Region: Abi; cl00558 691437000780 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 691437000781 oligomerisation interface [polypeptide binding]; other site 691437000782 mobile loop; other site 691437000783 roof hairpin; other site 691437000784 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 691437000785 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 691437000786 ring oligomerisation interface [polypeptide binding]; other site 691437000787 ATP/Mg binding site [chemical binding]; other site 691437000788 stacking interactions; other site 691437000789 hinge regions; other site 691437000790 tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224 691437000791 phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189 691437000792 Int/Topo IB signature motif; other site 691437000793 Domain of unknown function (DUF955); Region: DUF955; cl01076 691437000794 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 691437000795 non-specific DNA binding site [nucleotide binding]; other site 691437000796 salt bridge; other site 691437000797 sequence-specific DNA binding site [nucleotide binding]; other site 691437000798 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 691437000799 non-specific DNA binding site [nucleotide binding]; other site 691437000800 salt bridge; other site 691437000801 sequence-specific DNA binding site [nucleotide binding]; other site 691437000802 BRO family, N-terminal domain; Region: Bro-N; cl10591 691437000803 Phage antirepressor protein KilAC domain; Region: ANT; cl01462 691437000804 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 691437000805 Siphovirus Gp157; Region: Sipho_Gp157; pfam05565 691437000806 ERF superfamily; Region: ERF; pfam04404 691437000807 Helix-turn-helix domains; Region: HTH; cl00088 691437000808 Replication initiation and membrane attachment; Region: DnaB_2; cl12121 691437000809 Loader and inhibitor of phage G40P; Region: Inhibitor_G39P; pfam11417 691437000810 replicative DNA helicase; Region: DnaB; TIGR00665 691437000811 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 691437000812 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 691437000813 Walker A motif; other site 691437000814 ATP binding site [chemical binding]; other site 691437000815 Walker B motif; other site 691437000816 DNA binding loops [nucleotide binding] 691437000817 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cl00083 691437000818 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 691437000819 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 691437000820 dimer interface [polypeptide binding]; other site 691437000821 ssDNA binding site [nucleotide binding]; other site 691437000822 tetramer (dimer of dimers) interface [polypeptide binding]; other site 691437000823 Dimeric dUTPase [Carbohydrate transport and metabolism]; Region: COG4508 691437000824 dUTPase; Region: dUTPase_2; pfam08761 691437000825 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 691437000826 dimerization interface [polypeptide binding]; other site 691437000827 active site 691437000828 phage transcriptional activator, RinA family; Region: phage_rinA; TIGR01636 691437000829 Helix-turn-helix domains; Region: HTH; cl00088 691437000830 Hypothetical protein (DUF2513); Region: DUF2513; pfam10711 691437000831 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5410 691437000832 Terminase-like family; Region: Terminase_6; pfam03237 691437000833 Phage-related terminase [General function prediction only]; Region: COG5362; cl02216 691437000834 phage portal protein, PBSX family; Region: portal_PBSX; TIGR01540 691437000835 Phage-related protein [Function unknown]; Region: COG4695; cl01923 691437000836 Phage Mu protein F like protein; Region: Phage_Mu_F; cl10072 691437000837 Phage capsid family; Region: Phage_capsid; pfam05065 691437000838 Phage-related protein [Function unknown]; Region: COG5412 691437000839 membrane protein P6; Region: PHA01399 691437000840 membrane protein P6; Region: PHA01399 691437000841 Phage-related protein [Function unknown]; Region: COG4722; cl15832 691437000842 Phage tail protein; Region: Sipho_tail; pfam05709 691437000843 Prophage endopeptidase tail; Region: Prophage_tail; cl12123 691437000844 The GH18 (glycosyl hydrolase, family 18) type II chitinases hydrolyze chitin, an abundant polymer of beta-1,4-linked N-acetylglucosamine (GlcNAc) which is a major component of the cell wall of fungi and the exoskeleton of arthropods. Chitinases have...; Region: GH18_chitinase-like; cl10447 691437000845 active site 691437000846 Predicted glycosyl hydrolase [General function prediction only]; Region: COG3858 691437000847 Protein-interacting Bro1-like domain of mammalian Alix and related domains; Region: BRO1_Alix_like; cl14649 691437000848 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 691437000849 active site 691437000850 metal binding site [ion binding]; metal-binding site 691437000851 Sporulation related domain; Region: SPOR; cl10051 691437000852 fumarate hydratase; Reviewed; Region: fumC; PRK00485 691437000853 Class II fumarases; Region: Fumarase_classII; cd01362 691437000854 active site 691437000855 tetramer interface [polypeptide binding]; other site 691437000856 MoxR-like ATPases [General function prediction only]; Region: COG0714 691437000857 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 691437000858 Walker A motif; other site 691437000859 ATP binding site [chemical binding]; other site 691437000860 Walker B motif; other site 691437000861 arginine finger; other site 691437000862 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 691437000863 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 691437000864 Transglutaminase-like superfamily; Region: Transglut_core; cl10469 691437000865 Domain of unknown function (DUF4129); Region: DUF4129; pfam13559 691437000866 GMP synthase; Reviewed; Region: guaA; PRK00074 691437000867 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 691437000868 AMP/PPi binding site [chemical binding]; other site 691437000869 candidate oxyanion hole; other site 691437000870 catalytic triad [active] 691437000871 potential glutamine specificity residues [chemical binding]; other site 691437000872 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 691437000873 ATP Binding subdomain [chemical binding]; other site 691437000874 Ligand Binding sites [chemical binding]; other site 691437000875 Dimerization subdomain; other site 691437000876 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 691437000877 Domain of unknown function (DUF4306); Region: DUF4306; pfam14154 691437000878 flagellar basal body rod modification protein; Reviewed; Region: flgD; PRK05842 691437000879 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 691437000880 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 691437000881 putative dimer interface [polypeptide binding]; other site 691437000882 AIR carboxylase; Region: AIRC; cl00310 691437000883 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 691437000884 ATP-grasp domain; Region: ATP-grasp_4; cl03087 691437000885 adenylosuccinate lyase; Provisional; Region: PRK07492 691437000886 Adenylsuccinate lyase (ASL)_subgroup 1; Region: Adenylsuccinate_lyase_1; cd01360 691437000887 tetramer interface [polypeptide binding]; other site 691437000888 active site 691437000889 phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362 691437000890 bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415 691437000891 ATP binding site [chemical binding]; other site 691437000892 active site 691437000893 substrate binding site [chemical binding]; other site 691437000894 Phosphoribosylformylglycinamidine (FGAM) synthase; Region: PurS; cl00789 691437000895 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 691437000896 putative active site [active] 691437000897 catalytic triad [active] 691437000898 phosphoribosylformylglycinamidine synthase II; Provisional; Region: PRK01213 691437000899 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 691437000900 dimerization interface [polypeptide binding]; other site 691437000901 ATP binding site [chemical binding]; other site 691437000902 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 691437000903 dimerization interface [polypeptide binding]; other site 691437000904 ATP binding site [chemical binding]; other site 691437000905 amidophosphoribosyltransferase; Provisional; Region: PRK07631 691437000906 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 691437000907 active site 691437000908 tetramer interface [polypeptide binding]; other site 691437000909 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 691437000910 active site 691437000911 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 691437000912 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 691437000913 dimerization interface [polypeptide binding]; other site 691437000914 putative ATP binding site [chemical binding]; other site 691437000915 phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647 691437000916 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 691437000917 active site 691437000918 substrate binding site [chemical binding]; other site 691437000919 cosubstrate binding site; other site 691437000920 catalytic site [active] 691437000921 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 691437000922 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 691437000923 purine monophosphate binding site [chemical binding]; other site 691437000924 dimer interface [polypeptide binding]; other site 691437000925 putative catalytic residues [active] 691437000926 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 691437000927 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 691437000928 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 691437000929 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 691437000930 ATP-grasp domain; Region: ATP-grasp_4; cl03087 691437000931 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 691437000932 Protein of unknown function (DUF2892); Region: DUF2892; pfam11127 691437000933 Adenine deaminase [Nucleotide transport and metabolism]; Region: AdeC; COG1001 691437000934 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 691437000935 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 691437000936 active site 691437000937 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 691437000938 Protein of unknown function (DUF3048); Region: DUF3048; pfam11258 691437000939 Helix-turn-helix domains; Region: HTH; cl00088 691437000940 PcrB_like proteins. One member of this family, a protein from Archaeoglobus fulgidus, has been characterized as a (S)-3-O-geranylgeranylglyceryl phosphate synthase (AfGGGPS). AfGGGPS catalyzes the formation of an ether linkage between...; Region: PcrB_like; cd02812 691437000941 substrate binding site [chemical binding]; other site 691437000942 putative active site [active] 691437000943 dimer interface [polypeptide binding]; other site 691437000944 ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073 691437000945 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 691437000946 Family description; Region: UvrD_C_2; cl15862 691437000947 Family description; Region: UvrD_C_2; cl15862 691437000948 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 691437000949 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 691437000950 nucleotide binding pocket [chemical binding]; other site 691437000951 K-X-D-G motif; other site 691437000952 catalytic site [active] 691437000953 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 691437000954 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 691437000955 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786 691437000956 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 691437000957 Dimer interface [polypeptide binding]; other site 691437000958 CamS sex pheromone cAM373 precursor; Region: CamS; cl11554 691437000959 Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695 691437000960 Monoamine oxidase [Amino acid transport and metabolism]; Region: COG1231 691437000961 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 691437000962 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 691437000963 bifunctional aspartokinase I/homoserine dehydrogenase I; Provisional; Region: thrA; PRK09436 691437000964 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 691437000965 putative active site [active] 691437000966 Glu-tRNAGln amidotransferase C subunit; Region: Glu-tRNAGln; cl00495 691437000967 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 691437000968 Amidase; Region: Amidase; cl11426 691437000969 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 691437000970 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 691437000971 GatB domain; Region: GatB_Yqey; cl11497 691437000972 O-acetylhomoserine aminocarboxypropyltransferase; Validated; Region: PRK08248 691437000973 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 691437000974 homodimer interface [polypeptide binding]; other site 691437000975 substrate-cofactor binding pocket; other site 691437000976 pyridoxal 5'-phosphate binding site [chemical binding]; other site 691437000977 catalytic residue [active] 691437000978 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 691437000979 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 691437000980 Walker A/P-loop; other site 691437000981 ATP binding site [chemical binding]; other site 691437000982 Q-loop/lid; other site 691437000983 ABC transporter signature motif; other site 691437000984 Walker B; other site 691437000985 D-loop; other site 691437000986 H-loop/switch region; other site 691437000987 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 691437000988 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 691437000989 active site 691437000990 phosphorylation site [posttranslational modification] 691437000991 intermolecular recognition site; other site 691437000992 dimerization interface [polypeptide binding]; other site 691437000993 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 691437000994 DNA binding site [nucleotide binding] 691437000995 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 691437000996 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 691437000997 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 691437000998 dimer interface [polypeptide binding]; other site 691437000999 phosphorylation site [posttranslational modification] 691437001000 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 691437001001 ATP binding site [chemical binding]; other site 691437001002 Mg2+ binding site [ion binding]; other site 691437001003 G-X-G motif; other site 691437001004 ABC-2 type transporter; Region: ABC2_membrane; cl11417 691437001005 ABC-2 type transporter; Region: ABC2_membrane; cl11417 691437001006 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 691437001007 gallidermin-class lantibiotic protection ABC transporter, ATP-binding subunit; Region: galliderm_ABC; TIGR03740 691437001008 The BcrA subfamily represents ABC transporters involved in peptide antibiotic resistance. Bacitracin is a dodecapeptide antibiotic produced by B. licheniformis and B. subtilis. The synthesis of bacitracin is non-ribosomally catalyzed by a multienzyme...; Region: ABC_BcrA_bacitracin_resist; cd03268 691437001009 Walker A/P-loop; other site 691437001010 ATP binding site [chemical binding]; other site 691437001011 Q-loop/lid; other site 691437001012 ABC transporter signature motif; other site 691437001013 Walker B; other site 691437001014 D-loop; other site 691437001015 H-loop/switch region; other site 691437001016 Trans-Isoprenyl Diphosphate Synthases; Region: Trans_IPPS; cd00867 691437001017 substrate binding pocket [chemical binding]; other site 691437001018 substrate-Mg2+ binding site; other site 691437001019 aspartate-rich region 1; other site 691437001020 aspartate-rich region 2; other site 691437001021 Bacillus competence pheromone ComX; Region: ComX; pfam05952 691437001022 PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated; Region: PDZ; cl00117 691437001023 Histidine kinase; Region: HisKA_3; pfam07730 691437001024 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 691437001025 ATP binding site [chemical binding]; other site 691437001026 Mg2+ binding site [ion binding]; other site 691437001027 G-X-G motif; other site 691437001028 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 691437001029 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 691437001030 active site 691437001031 phosphorylation site [posttranslational modification] 691437001032 intermolecular recognition site; other site 691437001033 dimerization interface [polypeptide binding]; other site 691437001034 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 691437001035 dimerization interface [polypeptide binding]; other site 691437001036 DNA binding residues [nucleotide binding] 691437001037 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 691437001038 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 691437001039 FtsX-like permease family; Region: FtsX; cl15850 691437001040 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 691437001041 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 691437001042 Walker A/P-loop; other site 691437001043 ATP binding site [chemical binding]; other site 691437001044 Q-loop/lid; other site 691437001045 ABC transporter signature motif; other site 691437001046 Walker B; other site 691437001047 D-loop; other site 691437001048 H-loop/switch region; other site 691437001049 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 691437001050 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 691437001051 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 691437001052 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cd05709 691437001053 active site 691437001054 Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 2 [Coenzyme metabolism]; Region: ThiF; COG0476 691437001055 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 691437001056 ATP binding site [chemical binding]; other site 691437001057 substrate interface [chemical binding]; other site 691437001058 ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668 691437001059 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 691437001060 dimer interface [polypeptide binding]; other site 691437001061 conserved gate region; other site 691437001062 putative PBP binding loops; other site 691437001063 ABC-ATPase subunit interface; other site 691437001064 Transposase [DNA replication, recombination, and repair]; Region: COG5421 691437001065 NMT1-like family; Region: NMT1_2; cl15260 691437001066 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 691437001067 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 691437001068 TIGR02677 family protein; Region: TIGR02677 691437001069 Protein of unknown function (DUF2397); Region: DUF2397; pfam09660 691437001070 Protein of unknown function (DUF2398); Region: DUF2398; cl09875 691437001071 TIGR02680 family protein; Region: TIGR02680 691437001072 Putative exonuclease SbcCD, C subunit; Region: SbcCD_C; pfam13558 691437001073 TIGR02679 family protein; Region: TIGR02679 691437001074 Protein of unknown function N-terminus (DUF3323); Region: DUF3323; pfam11796 691437001075 Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718 691437001076 Putative transposase, YhgA-like; Region: Transposase_31; pfam04754 691437001077 conserved hypothetical protein (putative transposase or invertase); Region: T_den_put_tspse; TIGR01784 691437001078 Essential protein Yae1, N terminal; Region: Yae1_N; pfam09811 691437001079 L-Aminopeptidase D-amidase/D-esterase (DmpA) family; DmpA catalyzes the release of N-terminal D and L amino acids from peptide susbtrates. DmpA is synthesized as a single polypeptide precursor, which is autocatalytically cleaved to the active...; Region: DmpA; cd02253 691437001080 homodimer interface [polypeptide binding]; other site 691437001081 homotetramer interface [polypeptide binding]; other site 691437001082 active site pocket [active] 691437001083 cleavage site 691437001084 drug efflux system protein MdtG; Provisional; Region: PRK09874 691437001085 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 691437001086 putative substrate translocation pore; other site 691437001087 PspA/IM30 family; Region: PspA_IM30; pfam04012 691437001088 CobD/Cbib protein; Region: CobD_Cbib; cl00561 691437001089 Predicted membrane protein [Function unknown]; Region: COG1511 691437001090 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 691437001091 X-X-X-Leu-X-X-Gly heptad repeats; Region: xxxLxxG_by_4; TIGR03057 691437001092 X-X-X-Leu-X-X-Gly heptad repeats; Region: xxxLxxG_by_4; TIGR03057 691437001093 X-X-X-Leu-X-X-Gly heptad repeats; Region: xxxLxxG_by_4; TIGR03057 691437001094 ABC-2 type transporter; Region: ABC2_membrane; cl11417 691437001095 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 691437001096 Helix-turn-helix domains; Region: HTH; cl00088 691437001097 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 691437001098 dimer interface [polypeptide binding]; other site 691437001099 phosphorylation site [posttranslational modification] 691437001100 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 691437001101 ATP binding site [chemical binding]; other site 691437001102 Mg2+ binding site [ion binding]; other site 691437001103 G-X-G motif; other site 691437001104 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 691437001105 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 691437001106 active site 691437001107 phosphorylation site [posttranslational modification] 691437001108 intermolecular recognition site; other site 691437001109 dimerization interface [polypeptide binding]; other site 691437001110 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 691437001111 DNA binding site [nucleotide binding] 691437001112 PepSY-associated TM helix; Region: PepSY_TM_2; cl15813 691437001113 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149 691437001114 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 691437001115 protein binding site [polypeptide binding]; other site 691437001116 Orthopoxvirus protein of unknown function (DUF830); Region: DUF830; cl13998 691437001117 Protein of unknown function (DUF962); Region: DUF962; cl01879 691437001118 Putative transposase, YhgA-like; Region: Transposase_31; pfam04754 691437001119 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2268 691437001120 Band_7_flotillin: a subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. These two proteins are lipid raft-associated. Individual proteins of...; Region: Band_7_flotillin; cd03399 691437001121 putative lipid kinase; Reviewed; Region: PRK13337 691437001122 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; cl01255 691437001123 TRAM domain; Region: TRAM; cl01282 691437001124 23S rRNA (uracil-5-)-methyltransferase RumA; Region: rumA; TIGR00479 691437001125 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 691437001126 S-adenosylmethionine binding site [chemical binding]; other site 691437001127 Type I restriction-modification system methyltransferase subunit [Defense mechanisms]; Region: HsdM; COG0286 691437001128 HsdM N-terminal domain; Region: HsdM_N; pfam12161 691437001129 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 691437001130 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 691437001131 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 691437001132 Domain of unknown function (DUF4145); Region: DUF4145; pfam13643 691437001133 Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: HsdR; COG4096 691437001134 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; cl14958 691437001135 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 691437001136 ATP binding site [chemical binding]; other site 691437001137 putative Mg++ binding site [ion binding]; other site 691437001138 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 691437001139 Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548 691437001140 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 691437001141 dimerization interface [polypeptide binding]; other site 691437001142 putative DNA binding site [nucleotide binding]; other site 691437001143 putative Zn2+ binding site [ion binding]; other site 691437001144 Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814 691437001145 putative hydrophobic ligand binding site [chemical binding]; other site 691437001146 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265 691437001147 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 691437001148 S-adenosylmethionine binding site [chemical binding]; other site 691437001149 Sporulation control protein [General function prediction only]; Region: Spo0M; COG4326 691437001150 SpoOM protein; Region: Spo0M; pfam07070 691437001151 The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425 691437001152 active site 691437001153 8-oxo-dGMP binding site [chemical binding]; other site 691437001154 nudix motif; other site 691437001155 metal binding site [ion binding]; metal-binding site 691437001156 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 691437001157 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; cl11611 691437001158 NTP_transferases catalyze the transfer of nucleotides onto phosphosugars; Region: NTP_transferase; cd04181 691437001159 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 691437001160 active site 691437001161 Substrate binding site; other site 691437001162 Mg++ binding site; other site 691437001163 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 691437001164 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 691437001165 putative trimer interface [polypeptide binding]; other site 691437001166 putative CoA binding site [chemical binding]; other site 691437001167 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 691437001168 This family is most closely related to the GT1 family of glycosyltransferases. ORF704 in E. coli has been shown to be involved in the biosynthesis of O-specific mannose homopolysaccharides; Region: GT1_ecORF704_like; cd03822 691437001169 phosphoglucosamine mutase; Region: Arch_GlmM; TIGR03990 691437001170 The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a...; Region: PMM_PGM; cd03089 691437001171 active site 691437001172 substrate binding site [chemical binding]; other site 691437001173 metal binding site [ion binding]; metal-binding site 691437001174 Sensory domain found in PocR; Region: PocR; pfam10114 691437001175 Predicted sensor domain [Signal transduction mechanisms / Transcription]; Region: PocR; COG4936 691437001176 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 691437001177 DNA binding residues [nucleotide binding] 691437001178 dimerization interface [polypeptide binding]; other site 691437001179 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 691437001180 anti sigma factor interaction site; other site 691437001181 regulatory phosphorylation site [posttranslational modification]; other site 691437001182 PAS fold; Region: PAS_3; pfam08447 691437001183 Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain); Region: PAC; smart00086 691437001184 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 691437001185 PAS domain; Region: PAS_9; pfam13426 691437001186 putative active site [active] 691437001187 heme pocket [chemical binding]; other site 691437001188 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cl00120 691437001189 RDD family; Region: RDD; cl00746 691437001190 Diaminopimelate decarboxylase [Amino acid transport and metabolism]; Region: LysA; COG0019 691437001191 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme PvsE; Region: PLPDE_III_PvsE_like; cd06843 691437001192 dimer interface [polypeptide binding]; other site 691437001193 active site 691437001194 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 691437001195 catalytic residues [active] 691437001196 substrate binding site [chemical binding]; other site 691437001197 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 691437001198 putative substrate translocation pore; other site 691437001199 Siderophore synthetase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: RhbC; COG4264 691437001200 IucA / IucC family; Region: IucA_IucC; pfam04183 691437001201 Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276 691437001202 Siderophore synthetase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: RhbC; COG4264 691437001203 IucA / IucC family; Region: IucA_IucC; pfam04183 691437001204 Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276 691437001205 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 691437001206 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 691437001207 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 691437001208 dimer interface [polypeptide binding]; other site 691437001209 putative CheW interface [polypeptide binding]; other site 691437001210 thiamine biosynthesis protein ThiC; Provisional; Region: PRK09284 691437001211 ThiC-associated domain; Region: ThiC-associated; pfam13667 691437001212 ThiC family; Region: ThiC; cl08031 691437001213 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 691437001214 Probable transposase; Region: OrfB_IS605; pfam01385 691437001215 Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282 691437001216 LL-diaminopimelate aminotransferase; Provisional; Region: PRK09276 691437001217 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 691437001218 pyridoxal 5'-phosphate binding site [chemical binding]; other site 691437001219 homodimer interface [polypeptide binding]; other site 691437001220 catalytic residue [active] 691437001221 thiamine pyrophosphate protein; Validated; Region: PRK08199 691437001222 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 691437001223 PYR/PP interface [polypeptide binding]; other site 691437001224 dimer interface [polypeptide binding]; other site 691437001225 TPP binding site [chemical binding]; other site 691437001226 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; cl00815 691437001227 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cd00568 691437001228 TPP-binding site [chemical binding]; other site 691437001229 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 691437001230 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 691437001231 NAD(P) binding site [chemical binding]; other site 691437001232 catalytic residues [active] 691437001233 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 691437001234 Saccharopine dehydrogenase; Region: Saccharop_dh; pfam03435 691437001235 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 691437001236 Major Facilitator Superfamily; Region: MFS_1; pfam07690 691437001237 putative substrate translocation pore; other site 691437001238 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 691437001239 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 691437001240 DNA binding residues [nucleotide binding] 691437001241 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 691437001242 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 691437001243 Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319 691437001244 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; cl08390 691437001245 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 691437001246 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; cl03161 691437001247 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 691437001248 GT_2_like_f is a subfamily of the glycosyltransferase family 2 (GT-2) with unknown function; Region: GT_2_like_f; cd04182 691437001249 Ligand binding site; other site 691437001250 metal-binding site 691437001251 Xanthine and CO dehydrogenases maturation factor, XdhC/CoxF family [Posttranslational modification, protein turnover, chaperones]; Region: XdhC; COG1975 691437001252 XdhC and CoxI family; Region: XdhC_CoxI; pfam02625 691437001253 XdhC Rossmann domain; Region: XdhC_C; pfam13478 691437001254 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4877 691437001255 A subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual...; Region: Band_7_2; cd03402 691437001256 HutP; Region: HutP; cl07944 691437001257 Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332 691437001258 active sites [active] 691437001259 tetramer interface [polypeptide binding]; other site 691437001260 Integral membrane protein TerC family; Region: TerC; cl10468 691437001261 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 691437001262 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 691437001263 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl09108 691437001264 NlpC/P60 family; Region: NLPC_P60; cl11438 691437001265 Uncharacterized ACR, YkgG family COG1556; Region: DUF162; cl00674 691437001266 iron-sulfur cluster-binding protein; Region: TIGR00273 691437001267 Uncharacterized ACR, YkgG family COG1556; Region: DUF162; cl00674 691437001268 Domain of unknown function (DUF3390); Region: DUF3390; pfam11870 691437001269 CoB--CoM heterodisulfide reductase, subunit B; Region: CoB_CoM_SS_B; TIGR03288 691437001270 Cysteine-rich domain; Region: CCG; pfam02754 691437001271 Cysteine-rich domain; Region: CCG; pfam02754 691437001272 Transcriptional regulators [Transcription]; Region: FadR; COG2186 691437001273 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 691437001274 DNA-binding site [nucleotide binding]; DNA binding site 691437001275 FCD domain; Region: FCD; cl11656 691437001276 L-lactate permease; Region: Lactate_perm; cl00701 691437001277 glycolate transporter; Provisional; Region: PRK09695 691437001278 NlpC/P60 family; Region: NLPC_P60; cl11438 691437001279 Signal transduction histidine kinase regulating citrate/malate metabolism [Signal transduction mechanisms]; Region: CitA; COG3290 691437001280 PAS domain S-box; Region: sensory_box; TIGR00229 691437001281 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 691437001282 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 691437001283 metal binding site [ion binding]; metal-binding site 691437001284 active site 691437001285 I-site; other site 691437001286 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 691437001287 Domain of unknown function (DUF1992); Region: DUF1992; cl08096 691437001288 The Phox Homology domain, a phosphoinositide binding module; Region: PX_domain; cl02563 691437001289 phosphoinositide binding site [chemical binding]; other site 691437001290 Orthopoxvirus protein of unknown function (DUF830); Region: DUF830; cl13998 691437001291 Carboxylesterase family; Region: COesterase; pfam00135 691437001292 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 691437001293 substrate binding pocket [chemical binding]; other site 691437001294 catalytic triad [active] 691437001295 Preprotein translocase SecG subunit; Region: SecG; cl09123 691437001296 Esterase/lipase [General function prediction only]; Region: COG1647 691437001297 PhoPQ-activated pathogenicity-related protein; Region: PhoPQ_related; cl01750 691437001298 ribonuclease R; Region: RNase_R; TIGR02063 691437001299 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 691437001300 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 691437001301 RNB domain; Region: RNB; pfam00773 691437001302 S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase play an important...; Region: S1_RNase_R; cd04471 691437001303 RNA binding site [nucleotide binding]; other site 691437001304 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 691437001305 SmpB-tmRNA interface; other site 691437001306 Staygreen protein; Region: Staygreen; pfam12638 691437001307 LuxR family transcriptional regulatory, chaperone HchA-associated; Region: reg_near_HchA; TIGR03541 691437001308 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 691437001309 DNA binding residues [nucleotide binding] 691437001310 dimerization interface [polypeptide binding]; other site 691437001311 Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182 691437001312 Peptidase propeptide and YPEB domain; Region: PepSY; cl15815 691437001313 PepSY-associated TM helix; Region: PepSY_TM_2; cl15813 691437001314 Peptidase propeptide and YPEB domain; Region: PepSY; cl15815 691437001315 Protein of unknown function (DUF2642); Region: DUF2642; pfam10842 691437001316 Manganese catalase, ferritin-like diiron-binding domain; Region: Mn_catalase; cd01051 691437001317 dimanganese center [ion binding]; other site 691437001318 Transcriptional regulator [Transcription]; Region: LysR; COG0583 691437001319 Helix-turn-helix domains; Region: HTH; cl00088 691437001320 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 691437001321 dimerization interface [polypeptide binding]; other site 691437001322 4-hydroxyphenylacetate 3-monooxygenase, oxygenase component; Region: HpaB-1; TIGR02309 691437001323 4-hydroxyphenylacetate 3-hydroxylase C terminal; Region: HpaB; pfam03241 691437001324 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 691437001325 3,4-dihydroxyphenylacetate 2,3-dioxygenase; Region: HpaD; TIGR02295 691437001326 active site 691437001327 metal binding site [ion binding]; metal-binding site 691437001328 C-terminal domain of 3,4-dihydroxyphenylacetate 2,3-dioxygenase (HPCD), which catalyses the second step in the degradation of 4-hydroxyphenylacetate to succinate and pyruvate; belongs to the type I class II family of extradiol dioxygenases; Region: HPCD_C_class_II; cd07256 691437001329 tetramer interface [polypeptide binding]; other site 691437001330 active site 691437001331 metal binding site [ion binding]; metal-binding site 691437001332 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 691437001333 dihydrodipicolinate synthase; Region: dapA; TIGR00674 691437001334 dimer interface [polypeptide binding]; other site 691437001335 active site 691437001336 catalytic residue [active] 691437001337 4-hydroxyphenylacetate degradation bifunctional isomerase/decarboxylase, C-terminal subunit; Region: HpaG-C-term; TIGR02303 691437001338 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 691437001339 4-hydroxyphenylacetate degradation bifunctional isomerase/decarboxylase, C-terminal subunit; Region: HpaG-C-term; TIGR02303 691437001340 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 691437001341 5-carboxymethyl-2-hydroxymuconate isomerase (CHMI) is a trimeric enzyme catalyzing the isomerization of the unsaturated ketone 5-(carboxymethyl)-2-hydroxymuconate to 5-(carboxymethyl)-2-oxo-3-hexene-1,6-dionate. This is one step in the...; Region: CHMI; cd00580 691437001342 putative substrate binding pocket [chemical binding]; other site 691437001343 trimer interface [polypeptide binding]; other site 691437001344 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 691437001345 Human aldehyde dehydrogenase family 8 member A1-like; Region: ALDH_F8_HMSADH; cd07093 691437001346 NAD binding site [chemical binding]; other site 691437001347 catalytic residues [active] 691437001348 Transcriptional regulators [Transcription]; Region: GntR; COG1802 691437001349 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 691437001350 DNA-binding site [nucleotide binding]; DNA binding site 691437001351 FCD domain; Region: FCD; cl11656 691437001352 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 691437001353 Type I periplasmic binding component of ABC (ATPase Binding Cassette)-type transport systems that are predicted to be involved in uptake of amino acids; Region: PBP1_ABC-type_HAAT_like; cd06333 691437001354 putative ligand binding site [chemical binding]; other site 691437001355 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 691437001356 TM-ABC transporter signature motif; other site 691437001357 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 691437001358 TM-ABC transporter signature motif; other site 691437001359 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 691437001360 The Mj1267/LivG ABC transporter subfamily is involved in the transport of the hydrophobic amino acids leucine, isoleucine and valine. MJ1267 is a branched-chain amino acid transporter with 29% similarity to both the LivF and LivG components of the E; Region: ABC_Mj1267_LivG_branched; cd03219 691437001361 Walker A/P-loop; other site 691437001362 ATP binding site [chemical binding]; other site 691437001363 Q-loop/lid; other site 691437001364 ABC transporter signature motif; other site 691437001365 Walker B; other site 691437001366 D-loop; other site 691437001367 H-loop/switch region; other site 691437001368 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 691437001369 LivF (TM1139) is part of the LIV-I bacterial ABC-type two-component transport system that imports neutral, branched-chain amino acids. The E. coli branched-chain amino acid transporter comprises a heterodimer of ABC transporters (LivF and LivG), a...; Region: ABC_TM1139_LivF_branched; cd03224 691437001370 Walker A/P-loop; other site 691437001371 ATP binding site [chemical binding]; other site 691437001372 Q-loop/lid; other site 691437001373 ABC transporter signature motif; other site 691437001374 Walker B; other site 691437001375 D-loop; other site 691437001376 H-loop/switch region; other site 691437001377 Flavin Reductases; Region: FlaRed; cl00801 691437001378 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 691437001379 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 691437001380 coenzyme A disulfide reductase; Reviewed; Region: PRK09564 691437001381 pyruvate kinase; Validated; Region: PRK08187 691437001382 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl09155 691437001383 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl09155 691437001384 active site 691437001385 ECF-type riboflavin transporter, S component; Region: ECF-ribofla_trS; cl01942 691437001386 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 691437001387 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 691437001388 adenosylmethionine--8-amino-7-oxononanoate transaminase; Provisional; Region: PRK06916 691437001389 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 691437001390 inhibitor-cofactor binding pocket; inhibition site 691437001391 pyridoxal 5'-phosphate binding site [chemical binding]; other site 691437001392 catalytic residue [active] 691437001393 Coat F domain; Region: Coat_F; cl15836 691437001394 Proline dehydrogenase; Region: Pro_dh; cl03282 691437001395 YuzL-like protein; Region: YuzL; pfam14115 691437001396 3-hydroxyacyl-CoA dehydrogenase [Lipid metabolism]; Region: FadB; COG1250 691437001397 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 691437001398 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 691437001399 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 691437001400 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 691437001401 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 691437001402 substrate binding site [chemical binding]; other site 691437001403 oxyanion hole (OAH) forming residues; other site 691437001404 trimer interface [polypeptide binding]; other site 691437001405 acetyl-CoA acetyltransferase; Provisional; Region: PRK07661 691437001406 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 691437001407 dimer interface [polypeptide binding]; other site 691437001408 active site 691437001409 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 691437001410 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 691437001411 active site 691437001412 Arsenate Reductase (ArsC) family, unknown subfamily; uncharacterized proteins containing a CXXC motif with similarity to thioredoxin (TRX)-fold arsenic reductases, ArsC. Proteins containing a redox active CXXC motif like TRX and glutaredoxin (GRX)...; Region: ArsC_like; cd03036 691437001413 ArsC family; Region: ArsC; pfam03960 691437001414 putative ArsC-like catalytic residues; other site 691437001415 putative TRX-like catalytic residues [active] 691437001416 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 691437001417 lipoyl attachment site [posttranslational modification]; other site 691437001418 Protein of unknown function (DUF2553); Region: DUF2553; pfam10830 691437001419 TOPRIM_ RNase M5_like: The topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain found in Ribonuclease M5: (RNase M5) and other small primase-like proteins from bacteria and archaea. RNase M5 catalyzes the maturation of 5S rRNA in low...; Region: TOPRIM_RNase_M5_like; cd01027 691437001420 putative active site [active] 691437001421 putative metal binding site [ion binding]; other site 691437001422 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 691437001423 catalytic residues [active] 691437001424 DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153 691437001425 MetN (also known as YusC) is an ABC-type transporter encoded by metN of the metNPQ operon in Bacillus subtilis that is involved in methionine transport. Other members of this system include the MetP permease and the MetQ substrate binding protein. ABC...; Region: ABC_MetN_methionine_transporter; cd03258 691437001426 Walker A/P-loop; other site 691437001427 ATP binding site [chemical binding]; other site 691437001428 Q-loop/lid; other site 691437001429 ABC transporter signature motif; other site 691437001430 Walker B; other site 691437001431 D-loop; other site 691437001432 H-loop/switch region; other site 691437001433 NIL domain; Region: NIL; cl09633 691437001434 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 691437001435 dimer interface [polypeptide binding]; other site 691437001436 conserved gate region; other site 691437001437 ABC-ATPase subunit interface; other site 691437001438 NMT1-like family; Region: NMT1_2; cl15260 691437001439 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 691437001440 FeS assembly ATPase SufC; Region: sufC; TIGR01978 691437001441 ABC-type transport system involved in Fe-S cluster assembly, ATPase component. Biosynthesis of iron-sulfur clusters (Fe-S) depends on multiprotein systems. The SUF system of E. coli and Erwinia chrysanthemi is important for Fe-S biogenesis under...; Region: ABC_FeS_Assembly; cd03217 691437001442 Walker A/P-loop; other site 691437001443 ATP binding site [chemical binding]; other site 691437001444 Q-loop/lid; other site 691437001445 ABC transporter signature motif; other site 691437001446 Walker B; other site 691437001447 D-loop; other site 691437001448 H-loop/switch region; other site 691437001449 Cysteine desulfurase activator SufB [Posttranslational modification, protein turnover, chaperones]; Region: SufB; COG0719 691437001450 Uncharacterized protein family (UPF0051); Region: UPF0051; cl03223 691437001451 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 691437001452 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 691437001453 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 691437001454 catalytic residue [active] 691437001455 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 691437001456 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 691437001457 trimerization site [polypeptide binding]; other site 691437001458 active site 691437001459 Uncharacterized protein family (UPF0051); Region: UPF0051; cl03223 691437001460 FeS assembly protein SufB; Region: sufB; TIGR01980 691437001461 LysE type translocator; Region: LysE; cl00565 691437001462 Protein of unknown function DUF72; Region: DUF72; cl00777 691437001463 Predicted permeases [General function prediction only]; Region: COG0730; cl00498 691437001464 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 691437001465 Escherichia coli UshA-like family, N-terminal metallophosphatase domain; Region: MPP_UshA_N_like; cd00845 691437001466 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 691437001467 active site 691437001468 metal binding site [ion binding]; metal-binding site 691437001469 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 691437001470 Domain of unknown function (DUF1805); Region: DUF1805; cl01339 691437001471 Sporulation protein YunB (Spo_YunB); Region: Spore_YunB; cl09783 691437001472 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 691437001473 Type I periplasmic ligand-binding domain of uncharacterized ABC (Atpase Binding Cassette)-type active transport systems that are predicted to be involved in uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_12; cd06347 691437001474 putative ligand binding site [chemical binding]; other site 691437001475 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 691437001476 TM-ABC transporter signature motif; other site 691437001477 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 691437001478 TM-ABC transporter signature motif; other site 691437001479 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 691437001480 The Mj1267/LivG ABC transporter subfamily is involved in the transport of the hydrophobic amino acids leucine, isoleucine and valine. MJ1267 is a branched-chain amino acid transporter with 29% similarity to both the LivF and LivG components of the E; Region: ABC_Mj1267_LivG_branched; cd03219 691437001481 Walker A/P-loop; other site 691437001482 ATP binding site [chemical binding]; other site 691437001483 Q-loop/lid; other site 691437001484 ABC transporter signature motif; other site 691437001485 Walker B; other site 691437001486 D-loop; other site 691437001487 H-loop/switch region; other site 691437001488 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 691437001489 LivF (TM1139) is part of the LIV-I bacterial ABC-type two-component transport system that imports neutral, branched-chain amino acids. The E. coli branched-chain amino acid transporter comprises a heterodimer of ABC transporters (LivF and LivG), a...; Region: ABC_TM1139_LivF_branched; cd03224 691437001490 Walker A/P-loop; other site 691437001491 ATP binding site [chemical binding]; other site 691437001492 Q-loop/lid; other site 691437001493 ABC transporter signature motif; other site 691437001494 Walker B; other site 691437001495 D-loop; other site 691437001496 H-loop/switch region; other site 691437001497 Peptidase family M23; Region: Peptidase_M23; pfam01551 691437001498 lipoyl synthase; Provisional; Region: PRK05481 691437001499 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 691437001500 FeS/SAM binding site; other site 691437001501 Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ); Region: Spore_YhcN_YlaJ; pfam09580 691437001502 Protein of unknown function (DUF1027); Region: DUF1027; cl09961 691437001503 Protein of unknown function (DUF3055); Region: DUF3055; pfam11256 691437001504 Protein of unknown function DUF86; Region: DUF86; cl01031 691437001505 HAD-superfamily subfamily IIA hydrolase, TIGR01457; Region: HAD-SF-IIA-hyp2 691437001506 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 691437001507 active site 691437001508 motif I; other site 691437001509 motif II; other site 691437001510 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 691437001511 Phosphatidylglycerophosphatase A; a bacterial membrane-associated enzyme involved in lipid metabolism; Region: PgpA; cd06971 691437001512 tetramer interfaces [polypeptide binding]; other site 691437001513 binuclear metal-binding site [ion binding]; other site 691437001514 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 691437001515 glyoxylate reductase; Reviewed; Region: PRK13243 691437001516 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 691437001517 homoserine dehydrogenase; Provisional; Region: PRK06349 691437001518 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 691437001519 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 691437001520 ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881 691437001521 threonine synthase; Reviewed; Region: PRK06721 691437001522 Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants; Region: Thr-synth_1; cd01563 691437001523 homodimer interface [polypeptide binding]; other site 691437001524 pyridoxal 5'-phosphate binding site [chemical binding]; other site 691437001525 catalytic residue [active] 691437001526 homoserine kinase; Provisional; Region: PRK01212 691437001527 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 691437001528 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 691437001529 NifU-like domain; Region: NifU; cl00484 691437001530 Protein of unknown function (DUF1462); Region: DUF1462; cl11552 691437001531 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 691437001532 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 691437001533 Protein of unknown function (DUF1450); Region: DUF1450; cl11488 691437001534 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 691437001535 Diaminopimelate epimerase; Region: DAP_epimerase; cl14668 691437001536 Diaminopimelate epimerase; Region: DAP_epimerase; cl14668 691437001537 Iron-sulphur cluster biosynthesis; Region: Fe-S_biosyn; cl00400 691437001538 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 691437001539 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 691437001540 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 691437001541 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 691437001542 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 691437001543 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 691437001544 nudix motif; other site 691437001545 Putative membrane protein; Region: YuiB; pfam14068 691437001546 3D domain; Region: 3D; cl01439 691437001547 Cobalamin binding protein BtuF. These proteins have been shown to function as initial receptors in ABC transport of vitamin B12 (cobalamin) in eubacterial and some archaeal species. They belong to the TroA superfamily of helical backbone metal receptor...; Region: BtuF; cd01144 691437001548 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 691437001549 cobalamin binding residues [chemical binding]; other site 691437001550 putative BtuC binding residues; other site 691437001551 dimer interface [polypeptide binding]; other site 691437001552 Phosphate transport regulator (distant homolog of PhoU) [Inorganic ion transport and metabolism]; Region: COG1392 691437001553 Phosphate transporter family; Region: PHO4; cl00396 691437001554 ECF-type riboflavin transporter, S component; Region: ECF-ribofla_trS; cl01942 691437001555 Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055 691437001556 Permease P (pink-eyed dilution). Mutations in the human melanosomal P gene were responsible for classic phenotype of oculocutaneous albinism type 2 (OCA2). Although the precise function of the P protein is unknown, it was predicted to regulate the...; Region: P_permease; cd01116 691437001557 transmembrane helices; other site 691437001558 DEDDh 3'-5' exonuclease domain of Caenorhabditis elegans ERI-1, human 3' exonuclease, and similar proteins; Region: ERI-1_3'hExo_like; cd06133 691437001559 active site 691437001560 catalytic site [active] 691437001561 substrate binding site [chemical binding]; other site 691437001562 Cu/Zn superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodC; COG2032 691437001563 Copper/zinc superoxide dismutase (SOD). superoxide dismutases catalyse the conversion of superoxide radicals to molecular oxygen. Three evolutionarily distinct families of SODs are known, of which the copper/zinc-binding family is one. Defects in the...; Region: Cu-Zn_Superoxide_Dismutase; cd00305 691437001564 E-class dimer interface [polypeptide binding]; other site 691437001565 P-class dimer interface [polypeptide binding]; other site 691437001566 active site 691437001567 Cu2+ binding site [ion binding]; other site 691437001568 Zn2+ binding site [ion binding]; other site 691437001569 Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities [Amino acid transport and metabolism]; Region: MalY; COG1168 691437001570 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 691437001571 pyridoxal 5'-phosphate binding site [chemical binding]; other site 691437001572 homodimer interface [polypeptide binding]; other site 691437001573 catalytic residue [active] 691437001574 Domain of unknown function (DUF1871); Region: DUF1871; pfam08958 691437001575 Helix-turn-helix domains; Region: HTH; cl00088 691437001576 Helix-turn-helix domains; Region: HTH; cl00088 691437001577 hypothetical protein; Validated; Region: PRK07682 691437001578 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 691437001579 pyridoxal 5'-phosphate binding site [chemical binding]; other site 691437001580 homodimer interface [polypeptide binding]; other site 691437001581 catalytic residue [active] 691437001582 general stress protein 13; Validated; Region: PRK08059 691437001583 S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists of...; Region: S1_RPS1_repeat_hs4; cd05692 691437001584 RNA binding site [nucleotide binding]; other site 691437001585 Domain of unknown function (DUF378); Region: DUF378; cl00943 691437001586 Uncharacterized oxidoreductases, Fe-dependent alcohol dehydrogenase family [Energy production and conversion]; Region: COG1979 691437001587 Butanol dehydrogenase catalyzes the conversion of butyraldehyde to butanol with the cofactor NAD(P)H being oxidized in the process; Region: BDH; cd08187 691437001588 dimer interface [polypeptide binding]; other site 691437001589 active site 691437001590 metal binding site [ion binding]; metal-binding site 691437001591 glucose-6-phosphate isomerase; Provisional; Region: pgi; PRK14097 691437001592 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 691437001593 active site 691437001594 dimer interface [polypeptide binding]; other site 691437001595 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 691437001596 dimer interface [polypeptide binding]; other site 691437001597 active site 691437001598 YugN-like family; Region: YugN; pfam08868 691437001599 Ion channel; Region: Ion_trans_2; cl11596 691437001600 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 691437001601 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 691437001602 Small acid-soluble spore protein H family; Region: SspH; cl06949 691437001603 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 691437001604 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 691437001605 Coenzyme A binding pocket [chemical binding]; other site 691437001606 Staphylococcal nuclease homologues; Region: SNc; smart00318 691437001607 Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cl00140 691437001608 Catalytic site; other site 691437001609 Replication initiation and membrane attachment; Region: DnaB_2; cl12121 691437001610 MgtC family; Region: MgtC; pfam02308 691437001611 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 691437001612 EamA-like transporter family; Region: EamA; cl01037 691437001613 transglutaminase; Provisional; Region: tgl; PRK03187 691437001614 Protein of unknown function (DUF3221); Region: DUF3221; pfam11518 691437001615 chromosome segregation protein SMC, primarily archaeal type; Region: SMC_prok_A; TIGR02169 691437001616 iron-dicitrate transporter substrate-binding subunit; Provisional; Region: fecB; PRK11411 691437001617 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 691437001618 siderophore binding site; other site 691437001619 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 691437001620 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 691437001621 ABC-ATPase subunit interface; other site 691437001622 dimer interface [polypeptide binding]; other site 691437001623 putative PBP binding regions; other site 691437001624 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 691437001625 ABC-ATPase subunit interface; other site 691437001626 dimer interface [polypeptide binding]; other site 691437001627 putative PBP binding regions; other site 691437001628 LysE type translocator; Region: LysE; cl00565 691437001629 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 691437001630 Cation efflux family; Region: Cation_efflux; cl00316 691437001631 glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK05293 691437001632 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 691437001633 ligand binding site; other site 691437001634 oligomer interface; other site 691437001635 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 691437001636 dimer interface [polypeptide binding]; other site 691437001637 N-terminal domain interface [polypeptide binding]; other site 691437001638 sulfate 1 binding site; other site 691437001639 glucose-1-phosphate adenylyltransferase, GlgD subunit; Region: glgD; TIGR02092 691437001640 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 691437001641 ligand binding site; other site 691437001642 oligomer interface; other site 691437001643 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 691437001644 dimer interface [polypeptide binding]; other site 691437001645 N-terminal domain interface [polypeptide binding]; other site 691437001646 sulfate 1 binding site; other site 691437001647 glycogen synthase; Provisional; Region: glgA; PRK00654 691437001648 This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791 691437001649 ADP-binding pocket [chemical binding]; other site 691437001650 homodimer interface [polypeptide binding]; other site 691437001651 This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300 691437001652 homodimer interface [polypeptide binding]; other site 691437001653 glycogen/starch/alpha-glucan phosphorylases; Region: P_ylase; TIGR02093 691437001654 active site pocket [active] 691437001655 Mitochondrial biogenesis AIM24; Region: AIM24; cl00884 691437001656 Prokaryotic dksA/traR C4-type zinc finger; Region: zf-dskA_traR; cl00755 691437001657 UbiA prenyltransferase family; Region: UbiA; cl00337 691437001658 Isochorismate synthase [Coenzyme metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: MenF; COG1169 691437001659 chorismate binding enzyme; Region: Chorismate_bind; cl10555 691437001660 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1- carboxylate synthase; Validated; Region: PRK07449 691437001661 Pyrimidine (PYR) binding domain of 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexadiene-1- carboxylate synthase (MenD) and related proteins; Region: TPP_PYR_MenD; cd07037 691437001662 dimer interface [polypeptide binding]; other site 691437001663 tetramer interface [polypeptide binding]; other site 691437001664 PYR/PP interface [polypeptide binding]; other site 691437001665 TPP binding site [chemical binding]; other site 691437001666 Thiamine pyrophosphate (TPP) family, SHCHC synthase subfamily, TPP-binding module; composed of proteins similar to Escherichia coli 2-succinyl-6-hydroxyl-2,4-cyclohexadiene-1-carboxylic acid (SHCHC) synthase (also called MenD). SHCHC synthase plays a key...; Region: TPP_SHCHC_synthase; cd02009 691437001667 TPP-binding site; other site 691437001668 2-succinyl-6-hydroxy-2, 4-cyclohexadiene-1-carboxylate synthase; Region: menH_SHCHC; TIGR03695 691437001669 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 691437001670 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 691437001671 Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378 691437001672 substrate binding site [chemical binding]; other site 691437001673 oxyanion hole (OAH) forming residues; other site 691437001674 trimer interface [polypeptide binding]; other site 691437001675 O-succinylbenzoic acid--CoA ligase; Provisional; Region: PRK03640 691437001676 AMP-binding enzyme; Region: AMP-binding; cl15778 691437001677 AMP-binding enzyme; Region: AMP-binding; cl15778 691437001678 Domain of Unknown Function (DUF1540); Region: DUF1540; pfam07561 691437001679 Uncharacterized protein conserved in bacteria (DUF2325); Region: DUF2325; cl01811 691437001680 Highly conserved protein containing a thioredoxin domain [Posttranslational modification, protein turnover, chaperones]; Region: COG1331 691437001681 PQQ-dependent catabolism-associated beta-propeller protein; Region: PQQ_ABC_repeats; TIGR03866 691437001682 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 691437001683 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 691437001684 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 691437001685 Cytochrome c peroxidase [Inorganic ion transport and metabolism]; Region: MauG; COG1858 691437001686 Cytochrome bd-type quinol oxidase, subunit 2 [Energy production and conversion]; Region: AppB; COG1294 691437001687 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; cl00562 691437001688 Metal binding protein AcdA. These proteins have been shown to function in the ABC uptake of Zn2+ and Mn2+ and in competence for genetic transformation and adhesion. The AcdA proteins belong to the TroA superfamily of helical backbone metal receptor...; Region: AdcA; cd01017 691437001689 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 691437001690 metal binding site [ion binding]; metal-binding site 691437001691 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 691437001692 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 691437001693 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 691437001694 G4 box; other site 691437001695 G5 box; other site 691437001696 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; cl08458 691437001697 Haemolytic domain; Region: Haemolytic; cl00506 691437001698 S-Ribosylhomocysteinase (LuxS); Region: LuxS; cl00802 691437001699 Tumour necrosis factor receptor superfamily member 19; Region: RELT; pfam12606 691437001700 Ferritin-like domain; Region: Ferritin; pfam00210 691437001701 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 691437001702 dimerization interface [polypeptide binding]; other site 691437001703 DPS ferroxidase diiron center [ion binding]; other site 691437001704 ion pore; other site 691437001705 Holin family; Region: Phage_holin_4; cl01989 691437001706 nucleoside triphosphatase YtkD; Region: nudix_YtkD; TIGR02705 691437001707 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_8; cd04665 691437001708 nudix motif; other site 691437001709 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 691437001710 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 691437001711 dimer interface [polypeptide binding]; other site 691437001712 conserved gate region; other site 691437001713 putative PBP binding loops; other site 691437001714 ABC-ATPase subunit interface; other site 691437001715 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 691437001716 NrtD and SsuB are the ATP-binding subunits of the bacterial ABC-type nitrate and sulfonate transport systems, respectively. ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars; Region: ABC_NrtD_SsuB_transporters; cd03293 691437001717 Walker A/P-loop; other site 691437001718 ATP binding site [chemical binding]; other site 691437001719 Q-loop/lid; other site 691437001720 ABC transporter signature motif; other site 691437001721 Walker B; other site 691437001722 D-loop; other site 691437001723 H-loop/switch region; other site 691437001724 NMT1-like family; Region: NMT1_2; cl15260 691437001725 NMT1/THI5 like; Region: NMT1; pfam09084 691437001726 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 691437001727 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 691437001728 Protein of unknown function (DUF2584); Region: DUF2584; pfam10763 691437001729 Putative transposase, YhgA-like; Region: Transposase_31; pfam04754 691437001730 conserved hypothetical protein (putative transposase or invertase); Region: T_den_put_tspse; TIGR01784 691437001731 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 691437001732 putative substrate translocation pore; other site 691437001733 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_ATP; cd00484 691437001734 active site 691437001735 substrate-binding site [chemical binding]; other site 691437001736 metal-binding site [ion binding] 691437001737 ATP binding site [chemical binding]; other site 691437001738 S-adenosylmethionine synthetase; Validated; Region: PRK05250 691437001739 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 691437001740 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 691437001741 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 691437001742 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 691437001743 Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645 691437001744 trimer interface [polypeptide binding]; other site 691437001745 putative metal binding site [ion binding]; other site 691437001746 Protein of unknown function (DUF2600); Region: DUF2600; pfam10776 691437001747 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 691437001748 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 691437001749 Protein of unknown function (DUF2524); Region: DUF2524; pfam10732 691437001750 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 691437001751 Major Facilitator Superfamily; Region: MFS_1; pfam07690 691437001752 putative substrate translocation pore; other site 691437001753 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 691437001754 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 691437001755 HIGH motif; other site 691437001756 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 691437001757 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 691437001758 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 691437001759 active site 691437001760 KMSKS motif; other site 691437001761 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 691437001762 tRNA binding surface [nucleotide binding]; other site 691437001763 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 691437001764 active site residue [active] 691437001765 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 691437001766 non-specific DNA binding site [nucleotide binding]; other site 691437001767 salt bridge; other site 691437001768 sequence-specific DNA binding site [nucleotide binding]; other site 691437001769 Tetratricopeptide repeat; Region: TPR_12; pfam13424 691437001770 Zinc metalloprotease (elastase) [Amino acid transport and metabolism]; Region: LasB; COG3227 691437001771 Fungalysin/Thermolysin Propeptide Motif; Region: FTP; pfam07504 691437001772 Peptidase propeptide and YPEB domain; Region: PepSY; cl15815 691437001773 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 691437001774 Peptidase M4 family includes thermolysin, protealysin, aureolysin and neutral protease; Region: M4_neutral_protease; cd09597 691437001775 active site 691437001776 Zn binding site [ion binding]; other site 691437001777 Protein of unknown function (DUF2758); Region: DUF2758; pfam10957 691437001778 HI0933-like protein; Region: HI0933_like; pfam03486 691437001779 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 691437001780 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 691437001781 MatE; Region: MatE; cl10513 691437001782 MatE; Region: MatE; cl10513 691437001783 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 691437001784 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 691437001785 RNA binding surface [nucleotide binding]; other site 691437001786 PseudoU_synth_RsuA: Pseudouridine synthase, Escherichia coli RsuA like. This group is comprised of eukaryotic and bacterial proteins similar to Escherichia coli RsuA. Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA...; Region: PseudoU_synth_RsuA; cd02553 691437001787 active site 691437001788 uracil binding [chemical binding]; other site 691437001789 Helix-turn-helix domains; Region: HTH; cl00088 691437001790 dipeptidase PepV; Reviewed; Region: PRK07318 691437001791 M20 Peptidase Xaa-His dipeptidase (PepV) degrades hydrophobic dipeptides; Region: M20_PepV; cd03888 691437001792 active site 691437001793 metal binding site [ion binding]; metal-binding site 691437001794 sugar efflux transporter; Region: 2A0120; TIGR00899 691437001795 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 691437001796 putative substrate translocation pore; other site 691437001797 2'-5' RNA ligase; Region: 2_5_ligase; TIGR02258 691437001798 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 691437001799 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 691437001800 pullulanase, type I; Region: pulA_typeI; TIGR02104 691437001801 Early set domain associated with the catalytic domain of pullulanase (also called dextrinase and alpha-dextrin endo-1,6-alpha glucosidase); Region: E_set_Pullulanase; cd02860 691437001802 Alpha amylase catalytic domain found in Pullulanase (also called dextrinase; alpha-dextrin endo-1,6-alpha glucosidase), limit dextrinase, and related proteins; Region: AmyAc_Pullulanase_LD-like; cd11341 691437001803 Ca binding site [ion binding]; other site 691437001804 active site 691437001805 catalytic site [active] 691437001806 Phosphotransferase enzyme family; Region: APH; pfam01636 691437001807 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: APH_ChoK_like; cd05120 691437001808 active site 691437001809 substrate binding site [chemical binding]; other site 691437001810 ATP binding site [chemical binding]; other site 691437001811 YtzH-like protein; Region: YtzH; pfam14165 691437001812 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 691437001813 S-adenosylmethionine binding site [chemical binding]; other site 691437001814 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 691437001815 Predicted small secreted protein [Function unknown]; Region: COG5584 691437001816 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 691437001817 M42 Peptidase, Endoglucanases; Region: M42_Frv; cd05656 691437001818 oligomer interface [polypeptide binding]; other site 691437001819 active site 691437001820 metal binding site [ion binding]; metal-binding site 691437001821 Protein of unknown function DUF84; Region: NTPase_I-T; cl00866 691437001822 Protein of unknown function (DUF1444); Region: DUF1444; cl02011 691437001823 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 691437001824 putative tRNA-binding site [nucleotide binding]; other site 691437001825 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 691437001826 Ftsk gamma domain; Region: Ftsk_gamma; cl09645 691437001827 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 691437001828 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 691437001829 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 691437001830 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 691437001831 Bacterial protein of unknown function (DUF948); Region: DUF948; cl01972 691437001832 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 691437001833 bifunctional 3-deoxy-7-phosphoheptulonate synthase/chorismate mutase; Reviewed; Region: PRK12595 691437001834 Chorismate mutase type II; Region: CM_2; cl00693 691437001835 NeuB family; Region: NeuB; cl00496 691437001836 catabolite control protein A; Region: ccpA; TIGR01481 691437001837 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 691437001838 DNA binding site [nucleotide binding] 691437001839 domain linker motif; other site 691437001840 Ligand-binding domain of the catabolite control protein A (CcpA), which functions as the major transcriptional regulator of carbon catabolite repression/regulation; Region: PBP1_CcpA_like; cd06298 691437001841 dimerization interface [polypeptide binding]; other site 691437001842 effector binding site; other site 691437001843 Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123 691437001844 Histone deacetylase domain; Region: Hist_deacetyl; cl02986 691437001845 FOG: CBS domain [General function prediction only]; Region: COG0517 691437001846 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the acetoin utilization proteins in bacteria. Acetoin is a product of fermentative metabolism in many prokaryotic and eukaryotic microorganisms. They produce...; Region: CBS_pair_ACT_assoc; cd04584 691437001847 C-terminal ACT domain of the Bacillus subtilis acetoin utilization protein, AcuB; Region: ACT_AcuB; cd04883 691437001848 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 691437001849 acetyl-CoA synthetase; Provisional; Region: PRK04319 691437001850 Domain of unknown function (DUF3448); Region: DUF3448; pfam11930 691437001851 AMP-binding enzyme; Region: AMP-binding; cl15778 691437001852 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 691437001853 Transglycosylase; Region: Transgly; cl07896 691437001854 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 691437001855 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 691437001856 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 691437001857 catalytic core domain of tyrosinyl-tRNA and tryptophanyl-tRNA synthetase; Region: Tyr_Trp_RS_core; cd00395 691437001858 active site 691437001859 HIGH motif; other site 691437001860 dimer interface [polypeptide binding]; other site 691437001861 KMSKS motif; other site 691437001862 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 691437001863 RNA binding surface [nucleotide binding]; other site 691437001864 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 691437001865 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 691437001866 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 691437001867 RNA binding surface [nucleotide binding]; other site 691437001868 GAF domain; Region: GAF; cl15785 691437001869 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 691437001870 GAF domain; Region: GAF; cl15785 691437001871 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 691437001872 metal binding site [ion binding]; metal-binding site 691437001873 active site 691437001874 I-site; other site 691437001875 GAF domain; Region: GAF; cl15785 691437001876 histidinol-phosphatase; Reviewed; Region: PRK08123 691437001877 septation ring formation regulator EzrA; Provisional; Region: PRK04778 691437001878 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 691437001879 cysteine desulfurase DndA; Region: DNA_S_dndA; TIGR03235 691437001880 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 691437001881 catalytic residue [active] 691437001882 thiamine biosynthesis protein ThiI; Provisional; Region: PRK01565 691437001883 THUMP domain; Region: THUMP; cl12076 691437001884 ThiI is required for thiazole synthesis in the thiamine biosynthesis pathway. It belongs to the Adenosine Nucleotide Hydrolysis suoerfamily and predicted to bind to Adenosine nucleotide; Region: ThiI; cd01712 691437001885 Ligand Binding Site [chemical binding]; other site 691437001886 Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269 691437001887 Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases [Lipid metabolism]; Region: Acs; COG0365 691437001888 AMP-binding enzyme; Region: AMP-binding; cl15778 691437001889 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 691437001890 signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706 691437001891 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 691437001892 tandem repeat interface [polypeptide binding]; other site 691437001893 oligomer interface [polypeptide binding]; other site 691437001894 active site residues [active] 691437001895 RDD family; Region: RDD; cl00746 691437001896 Protein of unknown function (DUF2953); Region: DUF2953; pfam11167 691437001897 Sporulation protein YtfJ (Spore_YtfJ); Region: Spore_YtfJ; cl01596 691437001898 Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014 691437001899 dimer interface [polypeptide binding]; other site 691437001900 catalytic triad [active] 691437001901 peroxidatic and resolving cysteines [active] 691437001902 Adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0827 691437001903 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 691437001904 S-adenosylmethionine binding site [chemical binding]; other site 691437001905 Acetokinase family; Region: Acetate_kinase; cl01029 691437001906 propionate/acetate kinase; Provisional; Region: PRK12379 691437001907 SCP-2 sterol transfer family; Region: SCP2; cl01225 691437001908 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187 691437001909 AMP-binding enzyme; Region: AMP-binding; cl15778 691437001910 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 691437001911 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 691437001912 active site 691437001913 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 691437001914 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 691437001915 active site 691437001916 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 691437001917 enoyl-CoA hydratase; Provisional; Region: PRK06688 691437001918 substrate binding site [chemical binding]; other site 691437001919 oxyanion hole (OAH) forming residues; other site 691437001920 trimer interface [polypeptide binding]; other site 691437001921 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 691437001922 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 691437001923 NAD(P) binding site [chemical binding]; other site 691437001924 active site 691437001925 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 691437001926 acetyl-CoA acetyltransferases; Region: AcCoA-C-Actrans; TIGR01930 691437001927 dimer interface [polypeptide binding]; other site 691437001928 active site 691437001929 Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661 691437001930 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 691437001931 Zn-dependent alcohol dehydrogenases, class III [Energy production and conversion]; Region: AdhC; COG1062 691437001932 Class III alcohol dehydrogenase; Region: Zn_ADH_class_III; cd08279 691437001933 NAD binding site [chemical binding]; other site 691437001934 catalytic Zn binding site [ion binding]; other site 691437001935 substrate binding site [chemical binding]; other site 691437001936 structural Zn binding site [ion binding]; other site 691437001937 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 691437001938 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 691437001939 NAD(P) binding site [chemical binding]; other site 691437001940 catalytic residues [active] 691437001941 Ribonucleotide Reductase R2-like protein, Mn/Fe-binding domain; Region: RNRR2_Rv0233_like; cd07911 691437001942 active site 691437001943 diiron metal binding site [ion binding]; other site 691437001944 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 691437001945 DNA binding residues [nucleotide binding] 691437001946 dimerization interface [polypeptide binding]; other site 691437001947 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 691437001948 MPT binding site; other site 691437001949 trimer interface [polypeptide binding]; other site 691437001950 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 691437001951 Beta-eliminating lyase; Region: Beta_elim_lyase; pfam01212 691437001952 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 691437001953 catalytic residue [active] 691437001954 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 691437001955 Major Facilitator Superfamily; Region: MFS_1; pfam07690 691437001956 putative substrate translocation pore; other site 691437001957 argininosuccinate lyase; Provisional; Region: PRK02186 691437001958 ATP-grasp domain; Region: ATP-grasp_4; cl03087 691437001959 hypothetical protein; Provisional; Region: PRK07206 691437001960 ATP-grasp domain; Region: ATP-grasp_4; cl03087 691437001961 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 691437001962 dimerization interface [polypeptide binding]; other site 691437001963 putative DNA binding site [nucleotide binding]; other site 691437001964 putative Zn2+ binding site [ion binding]; other site 691437001965 acetyl-CoA synthetase; Provisional; Region: PRK04319 691437001966 AMP-binding enzyme; Region: AMP-binding; cl15778 691437001967 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 691437001968 Argininosuccinate synthase [Amino acid transport and metabolism]; Region: ArgG; COG0137 691437001969 Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate . In...; Region: Argininosuccinate_Synthase; cd01999 691437001970 ANP binding site [chemical binding]; other site 691437001971 Substrate Binding Site II [chemical binding]; other site 691437001972 Substrate Binding Site I [chemical binding]; other site 691437001973 argininosuccinate lyase; Provisional; Region: PRK00855 691437001974 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 691437001975 active sites [active] 691437001976 tetramer interface [polypeptide binding]; other site 691437001977 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 691437001978 Ligand Binding Site [chemical binding]; other site 691437001979 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 691437001980 classical (c) SDRs; Region: SDR_c; cd05233 691437001981 NAD(P) binding site [chemical binding]; other site 691437001982 active site 691437001983 Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686 691437001984 Alanine dehydrogenase/PNT, N-terminal domain; Region: AlaDh_PNT_N; cl15379 691437001985 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 691437001986 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 691437001987 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 691437001988 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 691437001989 active site 691437001990 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 691437001991 Predicted transcriptional regulator containing CBS domains [Transcription]; Region: COG4109 691437001992 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 691437001993 DNA-binding site [nucleotide binding]; DNA binding site 691437001994 DRTGG domain; Region: DRTGG; cl12147 691437001995 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with a DRTGG domain upstream. The function of the DRTGG domain, named after its conserved residues, is unknown. CBS is a small domain originally...; Region: CBS_pair_DRTGG_assoc; cd04596 691437001996 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 691437001997 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 691437001998 YtpI-like protein; Region: YtpI; pfam14007 691437001999 Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618 691437002000 DHH family; Region: DHH; pfam01368 691437002001 DHHA1 domain; Region: DHHA1; pfam02272 691437002002 Sporulation protein YtrH; Region: Spore_YtrH; pfam14034 691437002003 DNA polymerase III DnaE; Reviewed; Region: dnaE; PRK06920 691437002004 Bacterial DNA polymerase III alpha subunit; Region: DNA_pol3_alpha; pfam07733 691437002005 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 691437002006 generic binding surface II; other site 691437002007 generic binding surface I; other site 691437002008 Transcriptional regulators [Transcription]; Region: FadR; COG2186 691437002009 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 691437002010 DNA-binding site [nucleotide binding]; DNA binding site 691437002011 acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654 691437002012 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl15772 691437002013 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl15772 691437002014 acetyl-CoA carboxylase carboxyltransferase alpha subunit; Provisional; Region: accA; CHL00198 691437002015 Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to a subfamily of the PFKA family (cd00363) and include bacterial ATP-dependent...; Region: Bacterial_PFK; cd00763 691437002016 active site 691437002017 ADP/pyrophosphate binding site [chemical binding]; other site 691437002018 dimerization interface [polypeptide binding]; other site 691437002019 allosteric effector site; other site 691437002020 fructose-1,6-bisphosphate binding site; other site 691437002021 pyruvate kinase; Provisional; Region: PRK06354 691437002022 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cd00288 691437002023 domain interfaces; other site 691437002024 active site 691437002025 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; cl01586 691437002026 pheromone autoinducer 2 transporter; Reviewed; Region: tqsA; cl00465 691437002027 Protein of unknown function (DUF441); Region: DUF441; cl01041 691437002028 Bacillus subtilis (Bs) citrate synthase (CS)-II_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). 2MCS catalyzes the...; Region: BSuCS-II_like; cd06110 691437002029 dimer interface [polypeptide binding]; other site 691437002030 Citrate synthase; Region: Citrate_synt; pfam00285 691437002031 active site 691437002032 citrylCoA binding site [chemical binding]; other site 691437002033 oxalacetate/citrate binding site [chemical binding]; other site 691437002034 coenzyme A binding site [chemical binding]; other site 691437002035 catalytic triad [active] 691437002036 Isocitrate/isopropylmalate dehydrogenase; Region: Iso_dh; cl00445 691437002037 isocitrate dehydrogenase; Validated; Region: PRK07362 691437002038 malate dehydrogenase; Reviewed; Region: PRK06223 691437002039 L-lactate dehydrogenase-like malate dehydrogenase proteins; Region: LDH-like_MDH; cd01339 691437002040 NAD(P) binding site [chemical binding]; other site 691437002041 dimer interface [polypeptide binding]; other site 691437002042 tetramer (dimer of dimers) interface [polypeptide binding]; other site 691437002043 substrate binding site [chemical binding]; other site 691437002044 (R)-hydratase [(R)-specific enoyl-CoA hydratase] catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. (R)-hydratase contains a hot-dog fold similar to those of thioesterase...; Region: R_hydratase; cd03449 691437002045 dimer interaction site [polypeptide binding]; other site 691437002046 substrate-binding tunnel; other site 691437002047 active site 691437002048 catalytic site [active] 691437002049 substrate binding site [chemical binding]; other site 691437002050 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 691437002051 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 691437002052 active site 691437002053 phosphorylation site [posttranslational modification] 691437002054 intermolecular recognition site; other site 691437002055 dimerization interface [polypeptide binding]; other site 691437002056 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 691437002057 DNA binding site [nucleotide binding] 691437002058 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 691437002059 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 691437002060 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 691437002061 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 691437002062 dimer interface [polypeptide binding]; other site 691437002063 phosphorylation site [posttranslational modification] 691437002064 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 691437002065 ATP binding site [chemical binding]; other site 691437002066 Mg2+ binding site [ion binding]; other site 691437002067 G-X-G motif; other site 691437002068 DNA polymerase I; Provisional; Region: PRK05755 691437002069 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 691437002070 active site 691437002071 metal binding site 1 [ion binding]; metal-binding site 691437002072 putative 5' ssDNA interaction site; other site 691437002073 metal binding site 3; metal-binding site 691437002074 metal binding site 2 [ion binding]; metal-binding site 691437002075 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 691437002076 putative DNA binding site [nucleotide binding]; other site 691437002077 putative metal binding site [ion binding]; other site 691437002078 DEDDy 3'-5' exonuclease domain of family-A DNA polymerases; Region: DNA_polA_exo; cd06128 691437002079 active site 691437002080 catalytic site [active] 691437002081 substrate binding site [chemical binding]; other site 691437002082 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 691437002083 active site 691437002084 DNA binding site [nucleotide binding] 691437002085 catalytic site [active] 691437002086 formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103 691437002087 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 691437002088 DNA binding site [nucleotide binding] 691437002089 catalytic residue [active] 691437002090 H2TH interface [polypeptide binding]; other site 691437002091 putative catalytic residues [active] 691437002092 turnover-facilitating residue; other site 691437002093 intercalation triad [nucleotide binding]; other site 691437002094 8OG recognition residue [nucleotide binding]; other site 691437002095 putative reading head residues; other site 691437002096 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 691437002097 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 691437002098 dephospho-CoA kinase; Region: TIGR00152 691437002099 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 691437002100 CoA-binding site [chemical binding]; other site 691437002101 ATP-binding [chemical binding]; other site 691437002102 glyceraldehyde-3-phosphate dehydrogenase; Validated; Region: PRK07729 691437002103 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 691437002104 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; cl15856 691437002105 S-adenosylmethionine decarboxylase; Region: AdoMet_dc; cl00687 691437002106 PyridoxaL 5'-Phosphate Dependent Enzymes class IV (PLPDE_IV). This D-amino acid superfamily, one of five classes of PLPDE, consists of branched-chain amino acid aminotransferases (BCAT), D-amino acid transferases (DAAT), and 4-amino-4-deoxychorismate...; Region: PLPDE_IV; cl00224 691437002107 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 691437002108 ATP cone domain; Region: ATP-cone; pfam03477 691437002109 Replication initiation/membrane attachment protein [DNA replication, recombination, and repair]; Region: DnaB; COG3611 691437002110 Replication initiation and membrane attachment; Region: DnaB_2; cl12121 691437002111 primosomal protein DnaI; Reviewed; Region: PRK08939 691437002112 Primosomal protein DnaI N-terminus; Region: DnaI_N; pfam07319 691437002113 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 691437002114 Walker A motif; other site 691437002115 ATP binding site [chemical binding]; other site 691437002116 Walker B motif; other site 691437002117 YtxC-like family; Region: YtxC; cl08500 691437002118 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413 691437002119 TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667 691437002120 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; cl08469 691437002121 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 691437002122 active site 691437002123 dimer interface [polypeptide binding]; other site 691437002124 motif 1; other site 691437002125 motif 2; other site 691437002126 motif 3; other site 691437002127 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 691437002128 anticodon binding site; other site 691437002129 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 691437002130 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 691437002131 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 691437002132 Ribosomal protein L35; Region: Ribosomal_L35p; cl00392 691437002133 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 691437002134 23S rRNA binding site [nucleotide binding]; other site 691437002135 L21 binding site [polypeptide binding]; other site 691437002136 L13 binding site [polypeptide binding]; other site 691437002137 Protein of unknown function (DUF1294); Region: DUF1294; cl01311 691437002138 Dimeric dUTPase [Carbohydrate transport and metabolism]; Region: COG4508 691437002139 dUTPase; Region: dUTPase_2; pfam08761 691437002140 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 691437002141 M42 Peptidase, Endoglucanases; Region: M42_Frv; cd05656 691437002142 oligomer interface [polypeptide binding]; other site 691437002143 active site 691437002144 metal binding site [ion binding]; metal-binding site 691437002145 Small, acid-soluble spore protein I; Region: SSPI; cl07940 691437002146 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 691437002147 active site 691437002148 NTP binding site [chemical binding]; other site 691437002149 metal binding triad [ion binding]; metal-binding site 691437002150 antibiotic binding site [chemical binding]; other site 691437002151 Nucleotidyltransferase substrate binding protein like; Region: NTase_sub_bind; cl08495 691437002152 Peptide methionine sulfoxide reductase; Region: PMSR; cl00366 691437002153 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 691437002154 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; cl06870 691437002155 SpoU rRNA Methylase family; Region: SpoU_methylase; cl00362 691437002156 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 691437002157 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 691437002158 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 691437002159 dimer interface [polypeptide binding]; other site 691437002160 motif 1; other site 691437002161 active site 691437002162 motif 2; other site 691437002163 motif 3; other site 691437002164 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 691437002165 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 691437002166 putative tRNA-binding site [nucleotide binding]; other site 691437002167 B3/4 domain; Region: B3_4; cl11458 691437002168 tRNA synthetase B5 domain; Region: B5; cl08394 691437002169 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 691437002170 dimer interface [polypeptide binding]; other site 691437002171 motif 1; other site 691437002172 motif 3; other site 691437002173 motif 2; other site 691437002174 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; cl08386 691437002175 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 691437002176 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 691437002177 ABC-type molybdate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: ModA; COG0725 691437002178 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 691437002179 CrcB-like protein; Region: CRCB; cl09114 691437002180 CrcB-like protein; Region: CRCB; cl09114 691437002181 Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cd00016 691437002182 Alkaline phosphatase homologues; Region: alkPPc; smart00098 691437002183 active site 691437002184 dimer interface [polypeptide binding]; other site 691437002185 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 691437002186 Helix-turn-helix domains; Region: HTH; cl00088 691437002187 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 691437002188 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 691437002189 X-X-X-Leu-X-X-Gly heptad repeats; Region: xxxLxxG_by_4; TIGR03057 691437002190 X-X-X-Leu-X-X-Gly heptad repeats; Region: xxxLxxG_by_4; TIGR03057 691437002191 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 691437002192 Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693 691437002193 Type 1 glutamine amidotransferase (GATase1)-like domain found in proteins similar to Escherichia coli Hsp31 protein; Region: GATase1_Hsp31_like; cd03141 691437002194 potential catalytic triad [active] 691437002195 conserved cys residue [active] 691437002196 ribonuclease HIII; Provisional; Region: PRK00996 691437002197 Domain of unknown function (DUF3378); Region: DUF3378; pfam11858 691437002198 bacterial Ribonuclease HIII-like; Region: RNase_HII_bacteria_HIII_like; cd06590 691437002199 RNA/DNA hybrid binding site [nucleotide binding]; other site 691437002200 active site 691437002201 Cell division protein ZapA; Region: ZapA; cl01146 691437002202 Colicin V production protein; Region: Colicin_V; cl00567 691437002203 hypothetical protein; Provisional; Region: PRK08609 691437002204 Nucleotidyltransferase (NT) domain of family X DNA Polymerases; Region: NT_POLXc; cd00141 691437002205 active site 691437002206 primer binding site [nucleotide binding]; other site 691437002207 NTP binding site [chemical binding]; other site 691437002208 metal binding triad [ion binding]; metal-binding site 691437002209 recombination and DNA strand exchange inhibitor protein; Reviewed; Region: PRK00409 691437002210 MutS2 homologs in bacteria and eukaryotes. The MutS protein initiates DNA mismatch repair by recognizing mispaired and unpaired bases embedded in duplex DNA and activating endo- and exonucleases to remove the mismatch. Members of the MutS family also...; Region: ABC_MutS2; cd03280 691437002211 Walker A/P-loop; other site 691437002212 ATP binding site [chemical binding]; other site 691437002213 Q-loop/lid; other site 691437002214 ABC transporter signature motif; other site 691437002215 Walker B; other site 691437002216 D-loop; other site 691437002217 H-loop/switch region; other site 691437002218 Smr domain; Region: Smr; cl02619 691437002219 Predicted membrane protein [Function unknown]; Region: COG3766 691437002220 Domain of Unknown Function (DUF350); Region: DUF350; pfam03994 691437002221 Domain of Unknown Function (DUF350); Region: DUF350; pfam03994 691437002222 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06710 691437002223 AMP-binding enzyme; Region: AMP-binding; cl15778 691437002224 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 691437002225 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 691437002226 Helix-turn-helix domains; Region: HTH; cl00088 691437002227 YsiA-like protein, C-terminal region; Region: TetR_C_4; pfam08359 691437002228 enoyl-CoA hydratase; Provisional; Region: PRK07658 691437002229 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 691437002230 substrate binding site [chemical binding]; other site 691437002231 oxyanion hole (OAH) forming residues; other site 691437002232 trimer interface [polypeptide binding]; other site 691437002233 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 691437002234 Ligand binding site [chemical binding]; other site 691437002235 Electron transfer flavoprotein domain; Region: ETF; pfam01012 691437002236 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 691437002237 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715 691437002238 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 691437002239 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 691437002240 catalytic residues [active] 691437002241 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 691437002242 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 691437002243 NAD(P) binding site [chemical binding]; other site 691437002244 active site 691437002245 Sulfatase; Region: Sulfatase; cl10460 691437002246 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 691437002247 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 691437002248 Ligand binding site; other site 691437002249 Putative Catalytic site; other site 691437002250 DXD motif; other site 691437002251 Iron permease FTR1 family; Region: FTR1; cl00475 691437002252 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 691437002253 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 691437002254 GIY-YIG motif/motif A; other site 691437002255 active site 691437002256 catalytic site [active] 691437002257 putative DNA binding site [nucleotide binding]; other site 691437002258 metal binding site [ion binding]; metal-binding site 691437002259 UvrB/uvrC motif; Region: UVR; pfam02151 691437002260 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 691437002261 Protein of unknown function (DUF2507); Region: DUF2507; pfam10702 691437002262 Succinate:quinone oxidoreductase (SQR) Type B subfamily 1, transmembrane subunit; composed of proteins similar to Bacillus subtilis SQR. SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. Bacillus subtilis...; Region: SQR_TypeB_1_TM; cd03497 691437002263 putative Iron-sulfur protein interface [polypeptide binding]; other site 691437002264 succinate dehydrogenase (or fumarate reductase) cytochrome b subunit, b558 family; Region: sdhC_b558_fam; TIGR02046 691437002265 proximal heme binding site [chemical binding]; other site 691437002266 distal heme binding site [chemical binding]; other site 691437002267 putative dimer interface [polypeptide binding]; other site 691437002268 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK08641 691437002269 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 691437002270 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 691437002271 succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK08640 691437002272 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cl00159 691437002273 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 691437002274 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 691437002275 DNA binding residues [nucleotide binding] 691437002276 dimerization interface [polypeptide binding]; other site 691437002277 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 691437002278 Helix-turn-helix domains; Region: HTH; cl00088 691437002279 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 691437002280 Spore germination protein [General function prediction only]; Region: COG5401 691437002281 Sporulation and spore germination; Region: Germane; cl11253 691437002282 Sporulation and spore germination; Region: Germane; cl11253 691437002283 ribonuclease PH; Reviewed; Region: rph; PRK00173 691437002284 Ribonuclease PH; Region: RNase_PH_bact; cd11362 691437002285 hexamer interface [polypeptide binding]; other site 691437002286 active site 691437002287 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 691437002288 active site 691437002289 dimerization interface [polypeptide binding]; other site 691437002290 Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841 691437002291 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 691437002292 active site 691437002293 metal binding site [ion binding]; metal-binding site 691437002294 homotetramer interface [polypeptide binding]; other site 691437002295 D-Alanine aminotransferase (D-AAT_like): D-amino acid aminotransferase catalyzes transamination between D-amino acids and their respective alpha-keto acids. It plays a major role in the synthesis of bacterial cell wall components like D-alanine and...; Region: D-AAT_like; cd01558 691437002296 homodimer interface [polypeptide binding]; other site 691437002297 substrate-cofactor binding pocket; other site 691437002298 pyridoxal 5'-phosphate binding site [chemical binding]; other site 691437002299 catalytic residue [active] 691437002300 acetolactate synthase catalytic subunit; Reviewed; Region: PRK07710 691437002301 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 691437002302 PYR/PP interface [polypeptide binding]; other site 691437002303 dimer interface [polypeptide binding]; other site 691437002304 TPP binding site [chemical binding]; other site 691437002305 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; cl00815 691437002306 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 691437002307 TPP-binding site [chemical binding]; other site 691437002308 dimer interface [polypeptide binding]; other site 691437002309 acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895 691437002310 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 691437002311 putative valine binding site [chemical binding]; other site 691437002312 dimer interface [polypeptide binding]; other site 691437002313 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 691437002314 ketol-acid reductoisomerase; Provisional; Region: PRK05479 691437002315 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 691437002316 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 691437002317 2-isopropylmalate synthase; Validated; Region: PRK00915 691437002318 2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940 691437002319 active site 691437002320 catalytic residues [active] 691437002321 metal binding site [ion binding]; metal-binding site 691437002322 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; cl07212 691437002323 tartrate dehydrogenase; Provisional; Region: PRK08194 691437002324 Isocitrate/isopropylmalate dehydrogenase; Region: Iso_dh; cl00445 691437002325 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 691437002326 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 691437002327 substrate binding site [chemical binding]; other site 691437002328 ligand binding site [chemical binding]; other site 691437002329 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 691437002330 substrate binding site [chemical binding]; other site 691437002331 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 691437002332 binding surface 691437002333 Tetratricopeptide repeat; Region: TPR_16; pfam13432 691437002334 TPR motif; other site 691437002335 trigger factor; Provisional; Region: tig; PRK01490 691437002336 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; cl11587 691437002337 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 691437002338 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 691437002339 ClpX C4-type zinc finger; Region: zf-C4_ClpX; cl05964 691437002340 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 691437002341 Walker A motif; other site 691437002342 ATP binding site [chemical binding]; other site 691437002343 Walker B motif; other site 691437002344 arginine finger; other site 691437002345 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; cl11083 691437002346 ATP-dependent protease LonB; Region: spore_lonB; TIGR02902 691437002347 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 691437002348 Walker A motif; other site 691437002349 ATP binding site [chemical binding]; other site 691437002350 Walker B motif; other site 691437002351 arginine finger; other site 691437002352 Subunit ChlI of Mg-chelatase; Region: ChlI; cl12214 691437002353 ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466 691437002354 Found in ATP-dependent protease La (LON); Region: LON; smart00464 691437002355 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 691437002356 Walker A motif; other site 691437002357 ATP binding site [chemical binding]; other site 691437002358 Walker B motif; other site 691437002359 arginine finger; other site 691437002360 Subunit ChlI of Mg-chelatase; Region: ChlI; cl12214 691437002361 Predicted GTPase [General function prediction only]; Region: COG0218 691437002362 YihA (EngB) GTPase family; Region: YihA_EngB; cd01876 691437002363 G1 box; other site 691437002364 GTP/Mg2+ binding site [chemical binding]; other site 691437002365 Switch I region; other site 691437002366 G2 box; other site 691437002367 G3 box; other site 691437002368 Switch II region; other site 691437002369 G4 box; other site 691437002370 G5 box; other site 691437002371 glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045 691437002372 NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213 691437002373 tRNA; other site 691437002374 putative tRNA binding site [nucleotide binding]; other site 691437002375 putative NADP binding site [chemical binding]; other site 691437002376 Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745 691437002377 Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504 691437002378 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 691437002379 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cd00494 691437002380 domain interfaces; other site 691437002381 active site 691437002382 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 691437002383 active site 691437002384 Uroporphyrinogen-III synthase HemD; Region: HEM4; pfam02602 691437002385 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cd00384 691437002386 dimer interface [polypeptide binding]; other site 691437002387 active site 691437002388 Schiff base residues; other site 691437002389 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062 691437002390 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 691437002391 inhibitor-cofactor binding pocket; inhibition site 691437002392 pyridoxal 5'-phosphate binding site [chemical binding]; other site 691437002393 catalytic residue [active] 691437002394 stage VI sporulation protein D; Region: spore_VI_D; TIGR02907 691437002395 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118 691437002396 putative peptidoglycan binding site; other site 691437002397 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 691437002398 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 691437002399 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 691437002400 active site 691437002401 HIGH motif; other site 691437002402 nucleotide binding site [chemical binding]; other site 691437002403 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 691437002404 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 691437002405 active site 691437002406 KMSKS motif; other site 691437002407 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 691437002408 tRNA binding surface [nucleotide binding]; other site 691437002409 anticodon binding site; other site 691437002410 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 691437002411 folylpolyglutamate synthase/dihydrofolate synthase; Region: folC; TIGR01499 691437002412 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 691437002413 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 691437002414 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 691437002415 metal ion-dependent adhesion site (MIDAS); other site 691437002416 Bacterial Ig-like domain (group 2); Region: Big_2; cl02708 691437002417 PRC-barrel domain containing protein [General function prediction only]; Region: COG3881 691437002418 VanW like protein; Region: VanW; pfam04294 691437002419 G5 domain; Region: G5; pfam07501 691437002420 type IV-A pilus assembly ATPase PilB; Region: type_IV_pilB; TIGR02538 691437002421 Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157 691437002422 PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129 691437002423 Walker A motif; other site 691437002424 ATP binding site [chemical binding]; other site 691437002425 Walker B motif; other site 691437002426 pilus retraction protein PilT; Region: pilT_fam; TIGR01420 691437002427 Mitochondrial ribosomal death-associated protein 3; Region: DAP3; pfam10236 691437002428 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 691437002429 Walker A motif; other site 691437002430 ATP binding site [chemical binding]; other site 691437002431 Walker B motif; other site 691437002432 Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459 691437002433 Type II secretion system (T2SS), protein F; Region: T2SF; cl00906 691437002434 Type II secretion system (T2SS), protein F; Region: T2SF; cl00906 691437002435 Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989 691437002436 Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750 691437002437 Type IV leader peptidase family; Region: Peptidase_A24; cl02077 691437002438 Tfp pilus assembly protein, ATPase PilM [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilM; COG4972 691437002439 Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulG; COG2165 691437002440 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; cl06830 691437002441 Maf-like protein; Region: Maf; pfam02545 691437002442 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 691437002443 active site 691437002444 dimer interface [polypeptide binding]; other site 691437002445 hypothetical protein; Reviewed; Region: PRK00024 691437002446 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786 691437002447 helix-hairpin-helix signature motif; other site 691437002448 active site 691437002449 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 691437002450 MPN+ (JAMM) motif; other site 691437002451 Zinc-binding site [ion binding]; other site 691437002452 rod shape-determining protein MreB; Provisional; Region: PRK13927 691437002453 Actin; An ubiquitous protein involved in the formation of filaments that are a major component of the cytoskeleton. Interaction with myosin provides the basis of muscular contraction and many aspects of cell motility. Each actin protomer binds one...; Region: ACTIN; cl11528 691437002454 ATP binding site [chemical binding]; other site 691437002455 profilin binding site; other site 691437002456 rod shape-determining protein MreC; Provisional; Region: PRK13922 691437002457 rod shape-determining protein MreC; Region: MreC; pfam04085 691437002458 rod shape-determining protein MreD; Region: MreD; cl01087 691437002459 septum formation inhibitor; Reviewed; Region: minC; PRK00513 691437002460 Septum formation inhibitor MinC, C-terminal domain; Region: MinC_C; pfam03775 691437002461 Bacterial cell division requires the formation of a septum at mid-cell. The site is determined by the min operon products MinC, MinD and MinE. MinC is a nonspecific inhibitor of the septum protein FtsZ. MinE is the supressor of MinC. MinD plays a pivotal...; Region: MinD; cd02036 691437002462 Switch I; other site 691437002463 Switch II; other site 691437002464 Peptidase family M23; Region: Peptidase_M23; pfam01551 691437002465 SpoIVFB Site-2 protease (S2P), a zinc metalloprotease (MEROPS family M50B), regulates intramembrane proteolysis (RIP), and is involved in the pro-sigmaK pathway of bacterial spore formation. SpoIVFB (sporulation protein, stage IV cell wall formation, F...; Region: S2P-M50_SpoIVFB; cd06161 691437002466 active site 691437002467 putative substrate binding region [chemical binding]; other site 691437002468 Ribosomal prokaryotic L21 protein; Region: Ribosomal_L21p; cl00382 691437002469 Protein of unknown function (DUF464); Region: DUF464; cl01080 691437002470 Ribosomal L27 protein; Region: Ribosomal_L27; cl00359 691437002471 GTPase CgtA; Reviewed; Region: obgE; PRK12297 691437002472 GTP1/OBG; Region: GTP1_OBG; pfam01018 691437002473 Obg GTPase; Region: Obg; cd01898 691437002474 G1 box; other site 691437002475 GTP/Mg2+ binding site [chemical binding]; other site 691437002476 Switch I region; other site 691437002477 G2 box; other site 691437002478 G3 box; other site 691437002479 Switch II region; other site 691437002480 G4 box; other site 691437002481 G5 box; other site 691437002482 Domain of unknown function (DUF1967); Region: DUF1967; cl07779 691437002483 hypothetical protein; Provisional; Region: PRK04435 691437002484 C-terminal ACT domain of a small (; 147 a.a.) putative phenylalanine biosynthetic pathway protein described in Bacillus subtilis (BS) PheB (PheB-BS) and related domains; Region: ACT_PheB-BS; cd04888 691437002485 prephenate dehydratase; Provisional; Region: PRK11898 691437002486 Prephenate dehydratase; Region: PDT; pfam00800 691437002487 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 691437002488 putative L-Phe binding site [chemical binding]; other site 691437002489 Predicted small molecule binding protein (contains 3H domain) [General function prediction only]; Region: COG1827 691437002490 Helix-turn-helix domains; Region: HTH; cl00088 691437002491 3H domain; Region: 3H; pfam02829 691437002492 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 691437002493 cysteine desulfurase DndA; Region: DNA_S_dndA; TIGR03235 691437002494 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 691437002495 catalytic residue [active] 691437002496 L-aspartate oxidase; Provisional; Region: PRK08071 691437002497 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 691437002498 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 691437002499 nicotinate-nucleotide pyrophosphorylase; Provisional; Region: PRK08072 691437002500 Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572 691437002501 dimerization interface [polypeptide binding]; other site 691437002502 active site 691437002503 Quinolinate synthetase A protein; Region: NadA; cl00420 691437002504 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118 691437002505 putative peptidoglycan binding site; other site 691437002506 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 691437002507 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 691437002508 NAD synthase; Region: NAD_synthase; pfam02540 691437002509 homodimer interface [polypeptide binding]; other site 691437002510 NAD binding pocket [chemical binding]; other site 691437002511 ATP binding pocket [chemical binding]; other site 691437002512 Mg binding site [ion binding]; other site 691437002513 active-site loop [active] 691437002514 Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ); Region: Spore_YhcN_YlaJ; pfam09580 691437002515 Transcriptional regulator; Region: Transcrip_reg; cl00361 691437002516 Bypass of Forespore C, N terminal; Region: BOFC_N; pfam08977 691437002517 BofC C-terminal domain; Region: BofC_C; pfam08955 691437002518 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 691437002519 RuvA N terminal domain; Region: RuvA_N; pfam01330 691437002520 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 691437002521 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 691437002522 Walker A motif; other site 691437002523 ATP binding site [chemical binding]; other site 691437002524 Walker B motif; other site 691437002525 arginine finger; other site 691437002526 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 691437002527 Protein of unknown function (DUF2905); Region: DUF2905; pfam11146 691437002528 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147 691437002529 Queuosine biosynthesis protein; Region: Queuosine_synth; cl00523 691437002530 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; cl00409 691437002531 tRNA-guanine transglycosylases, various specificities; Region: tgt_general; TIGR00449 691437002532 Preprotein translocase subunit; Region: YajC; cl00806 691437002533 Protein of unknown function (DUF3792); Region: DUF3792; cl14821 691437002534 stage V sporulation protein B; Region: spore_V_B; TIGR02900 691437002535 MatE; Region: MatE; cl10513 691437002536 MatE; Region: MatE; cl10513 691437002537 Post-transcriptional regulator; Region: Post_transc_reg; pfam13797 691437002538 bifunctional preprotein translocase subunit SecD/SecF; Reviewed; Region: PRK13024 691437002539 SecD/SecF GG Motif; Region: Sec_GG; pfam07549 691437002540 Protein export membrane protein; Region: SecD_SecF; cl14618 691437002541 SecD/SecF GG Motif; Region: Sec_GG; pfam07549 691437002542 Protein export membrane protein; Region: SecD_SecF; cl14618 691437002543 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 691437002544 Cation efflux family; Region: Cation_efflux; cl00316 691437002545 single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644 691437002546 DHH family; Region: DHH; pfam01368 691437002547 YjeF-related protein N-terminus; Region: YjeF_N; cl00318 691437002548 DHHA1 domain; Region: DHHA1; pfam02272 691437002549 Single-strand DNA-specific exonuclease, C terminal domain; Region: ssDNA-exonuc_C; cl11538 691437002550 Adenine/guanine phosphoribosyltransferases and related PRPP-binding proteins [Nucleotide transport and metabolism]; Region: Apt; COG0503 691437002551 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 691437002552 active site 691437002553 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 691437002554 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 691437002555 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 691437002556 synthetase active site [active] 691437002557 NTP binding site [chemical binding]; other site 691437002558 metal binding site [ion binding]; metal-binding site 691437002559 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 691437002560 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 691437002561 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563 691437002562 putative active site [active] 691437002563 dimerization interface [polypeptide binding]; other site 691437002564 putative tRNAtyr binding site [nucleotide binding]; other site 691437002565 peroxiredoxin; Region: AhpC; TIGR03137 691437002566 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 691437002567 dimer interface [polypeptide binding]; other site 691437002568 decamer (pentamer of dimers) interface [polypeptide binding]; other site 691437002569 catalytic triad [active] 691437002570 peroxidatic and resolving cysteines [active] 691437002571 alkyl hydroperoxide reductase subunit F; Provisional; Region: PRK15317 691437002572 Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) family, N-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which in turn catalyzes the reduction...; Region: AhpF_NTD_N; cd02974 691437002573 catalytic residue [active] 691437002574 TRX-GRX-like family, Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) subfamily, C-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which then...; Region: AhpF_NTD_C; cd03026 691437002575 catalytic residues [active] 691437002576 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 691437002577 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 691437002578 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: HisRS-like_core; cd00773 691437002579 dimer interface [polypeptide binding]; other site 691437002580 motif 1; other site 691437002581 active site 691437002582 motif 2; other site 691437002583 motif 3; other site 691437002584 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 691437002585 anticodon binding site; other site 691437002586 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 691437002587 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 691437002588 dimer interface [polypeptide binding]; other site 691437002589 anticodon binding site; other site 691437002590 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of the...; Region: AspRS_core; cd00777 691437002591 homodimer interface [polypeptide binding]; other site 691437002592 motif 1; other site 691437002593 active site 691437002594 motif 2; other site 691437002595 GAD domain; Region: GAD; pfam02938 691437002596 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of the...; Region: AspRS_core; cd00777 691437002597 motif 3; other site 691437002598 Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 1 [Coenzyme metabolism]; Region: COG1179 691437002599 Family of activating enzymes (E1) of ubiquitin-like proteins related to the E.coli hypothetical protein ygdL. The common reaction mechanism catalyzed by E1-like enzymes begins with a nucleophilic attack of the C-terminal carboxylate of the ubiquitin-like...; Region: YgdL_like; cd00755 691437002600 putative ATP binding site [chemical binding]; other site 691437002601 putative substrate interface [chemical binding]; other site 691437002602 putative spore coat protein regulator protein YlbO; Provisional; Region: PRK13923 691437002603 transcription factor, RsfA family; Region: DNA_bind_RsfA; TIGR02894 691437002604 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 691437002605 Protein export membrane protein; Region: SecD_SecF; cl14618 691437002606 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 691437002607 Helix-turn-helix domains; Region: HTH; cl00088 691437002608 recombination factor protein RarA; Reviewed; Region: PRK13342 691437002609 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 691437002610 Walker A motif; other site 691437002611 ATP binding site [chemical binding]; other site 691437002612 Walker B motif; other site 691437002613 arginine finger; other site 691437002614 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 691437002615 Predicted transcriptional regulator [Transcription]; Region: COG1959 691437002616 Helix-turn-helix domains; Region: HTH; cl00088 691437002617 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 691437002618 cysteine desulfurase DndA; Region: DNA_S_dndA; TIGR03235 691437002619 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 691437002620 catalytic residue [active] 691437002621 tRNA methyl transferase; Region: tRNA_Me_trans; pfam03054 691437002622 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 691437002623 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 691437002624 binding surface 691437002625 TPR repeat; Region: TPR_11; pfam13414 691437002626 TPR motif; other site 691437002627 TPR repeat; Region: TPR_11; pfam13414 691437002628 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 691437002629 binding surface 691437002630 TPR motif; other site 691437002631 TPR repeat; Region: TPR_11; pfam13414 691437002632 helicase, putative, RecD/TraA family; Region: recD_rel; TIGR01448 691437002633 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 691437002634 Family description; Region: UvrD_C_2; cl15862 691437002635 Photosynthetic reaction center (RC) complex, subunit H; RC is an integral membrane protein-pigment complex which catalyzes light-induced reduction of ubiquinone to ubiquinol, generating a transmembrane electrochemical gradient of protons used to produce...; Region: PRCH; cl09959 691437002636 Photosynthetic reaction center (RC) complex, subunit H; RC is an integral membrane protein-pigment complex which catalyzes light-induced reduction of ubiquinone to ubiquinol, generating a transmembrane electrochemical gradient of protons used to produce...; Region: PRCH; cl09959 691437002637 Protein of unknown function (DUF3918); Region: DUF3918; pfam13056 691437002638 Domain of unknown function DUF20; Region: UPF0118; pfam01594 691437002639 pheromone autoinducer 2 transporter; Reviewed; Region: tqsA; cl00465 691437002640 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 691437002641 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent formation of...; Region: AlaRS_core; cd00673 691437002642 motif 1; other site 691437002643 active site 691437002644 motif 2; other site 691437002645 motif 3; other site 691437002646 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; cl08469 691437002647 DHHA1 domain; Region: DHHA1; pfam02272 691437002648 Bacterial protein of unknown function (DUF965); Region: DUF965; cl01857 691437002649 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD includes...; Region: RuvC_resolvase; cl00243 691437002650 Protein of unknown function (DUF1292); Region: DUF1292; cl01608 691437002651 YceG-like family; Region: YceG; pfam02618 691437002652 proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010 691437002653 dimerization interface [polypeptide binding]; other site 691437002654 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 691437002655 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 691437002656 Peptidase family U32; Region: Peptidase_U32; cl03113 691437002657 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 691437002658 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl09108 691437002659 Peptidase family U32; Region: Peptidase_U32; cl03113 691437002660 Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage pathway; Region: UMPK; cd02023 691437002661 Sugar specificity; other site 691437002662 Pyrimidine base specificity; other site 691437002663 ATP-binding site [chemical binding]; other site 691437002664 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 691437002665 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 691437002666 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 691437002667 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 691437002668 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 691437002669 Protein of unknown function (DUF1510); Region: DUF1510; pfam07423 691437002670 Protein of unknown function (DUF2536); Region: DUF2536; pfam10750 691437002671 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 691437002672 S-adenosylmethionine binding site [chemical binding]; other site 691437002673 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 691437002674 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 691437002675 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 691437002676 dimer interface [polypeptide binding]; other site 691437002677 pyridoxal 5'-phosphate binding site [chemical binding]; other site 691437002678 catalytic residue [active] 691437002679 cystathionine beta-lyase; Provisional; Region: PRK07671 691437002680 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 691437002681 homodimer interface [polypeptide binding]; other site 691437002682 substrate-cofactor binding pocket; other site 691437002683 pyridoxal 5'-phosphate binding site [chemical binding]; other site 691437002684 catalytic residue [active] 691437002685 YrhC-like protein; Region: YrhC; pfam14143 691437002686 sporulation sigma factor SigK; Reviewed; Region: PRK05803 691437002687 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 691437002688 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 691437002689 DNA binding residues [nucleotide binding] 691437002690 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 691437002691 Sodium:dicarboxylate symporter family; Region: SDF; cl00573 691437002692 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 691437002693 pheromone autoinducer 2 transporter; Reviewed; Region: tqsA; cl00465 691437002694 Domain of unknown function DUF20; Region: UPF0118; pfam01594 691437002695 flagellar motor protein MotB; Reviewed; Region: motB; PRK07734 691437002696 Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677 691437002697 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 691437002698 ligand binding site [chemical binding]; other site 691437002699 flagellar motor protein MotA; Validated; Region: PRK08124 691437002700 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 691437002701 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 691437002702 Phosphatidylserine decarboxylase; Region: PS_Dcarbxylase; cl03656 691437002703 Sporulation inhibitor A; Region: Sda; pfam08970 691437002704 Predicted hydrolase of the HAD superfamily [General function prediction only]; Region: COG2179 691437002705 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 691437002706 active site 691437002707 motif I; other site 691437002708 motif II; other site 691437002709 GTPase YqeH; Provisional; Region: PRK13796 691437002710 Circularly permuted YqeH GTPase; Region: YqeH; cd01855 691437002711 GTP/Mg2+ binding site [chemical binding]; other site 691437002712 G4 box; other site 691437002713 G5 box; other site 691437002714 G1 box; other site 691437002715 Switch I region; other site 691437002716 G2 box; other site 691437002717 G3 box; other site 691437002718 Switch II region; other site 691437002719 shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258 691437002720 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 691437002721 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 691437002722 shikimate binding site; other site 691437002723 NAD(P) binding site [chemical binding]; other site 691437002724 CRS1 / YhbY (CRM) domain; Region: CRS1_YhbY; cl00663 691437002725 nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071 691437002726 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 691437002727 active site 691437002728 (T/H)XGH motif; other site 691437002729 Predicted HD superfamily hydrolase involved in NAD metabolism [Coenzyme metabolism]; Region: COG1713 691437002730 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 691437002731 Zn2+ binding site [ion binding]; other site 691437002732 Mg2+ binding site [ion binding]; other site 691437002733 Oligomerisation domain; Region: Oligomerisation; cl00519 691437002734 Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226 691437002735 SAM-dependent methyltransferases [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: SmtA; COG0500 691437002736 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 691437002737 S-adenosylmethionine binding site [chemical binding]; other site 691437002738 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 691437002739 Pyrroline-5-carboxylate reductase [Amino acid transport and metabolism]; Region: ProC; COG0345 691437002740 SLBB domain; Region: SLBB; pfam10531 691437002741 comEA protein; Region: comE; TIGR01259 691437002742 Deoxycytidylate deaminase domain. Deoxycytidylate deaminase catalyzes the deamination of dCMP to dUMP, providing the nucleotide substrate for thymidylate synthase. The enzyme binds Zn++, which is required for catalytic activity. The activity of the...; Region: deoxycytidylate_deaminase; cd01286 691437002743 catalytic motif [active] 691437002744 Zn binding site [ion binding]; other site 691437002745 DNA internalization-related competence protein ComEC/Rec2; Region: ComEC_Rec2; TIGR00361 691437002746 Domain of unknown function (DUF4131); Region: DUF4131; pfam13567 691437002747 Competence protein; Region: Competence; cl00471 691437002748 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 691437002749 YqzM-like protein; Region: YqzM; pfam14141 691437002750 DNA polymerase III subunit delta; Reviewed; Region: holA; PRK05574 691437002751 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 691437002752 Ribosomal protein S20; Region: Ribosomal_S20p; cl00384 691437002753 Germination protease; Region: Peptidase_A25; cl04057 691437002754 Stage II sporulation protein P (SpoIIP); Region: SpoIIP; pfam07454 691437002755 stage II sporulation protein P; Region: spore_II_P; TIGR02867 691437002756 Protein of unknown function (DUF3679); Region: DUF3679; pfam12438 691437002757 GTP-binding protein LepA; Provisional; Region: PRK05433 691437002758 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 691437002759 G1 box; other site 691437002760 putative GEF interaction site [polypeptide binding]; other site 691437002761 GTP/Mg2+ binding site [chemical binding]; other site 691437002762 Switch I region; other site 691437002763 G2 box; other site 691437002764 G3 box; other site 691437002765 Switch II region; other site 691437002766 G4 box; other site 691437002767 G5 box; other site 691437002768 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 691437002769 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 691437002770 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 691437002771 coproporphyrinogen III oxidase; Provisional; Region: PRK08599 691437002772 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 691437002773 FeS/SAM binding site; other site 691437002774 HemN C-terminal domain; Region: HemN_C; pfam06969 691437002775 heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082 691437002776 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 691437002777 HrcA protein C terminal domain; Region: HrcA; pfam01628 691437002778 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 691437002779 dimer interface [polypeptide binding]; other site 691437002780 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 691437002781 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 691437002782 Actin; An ubiquitous protein involved in the formation of filaments that are a major component of the cytoskeleton. Interaction with myosin provides the basis of muscular contraction and many aspects of cell motility. Each actin protomer binds one...; Region: ACTIN; cl11528 691437002783 ATP binding site [chemical binding]; other site 691437002784 profilin binding site; other site 691437002785 chaperone protein DnaJ; Provisional; Region: PRK14280 691437002786 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 691437002787 HSP70 interaction site [polypeptide binding]; other site 691437002788 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262 691437002789 substrate binding site [polypeptide binding]; other site 691437002790 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 691437002791 Zn binding sites [ion binding]; other site 691437002792 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 691437002793 dimer interface [polypeptide binding]; other site 691437002794 Ribosomal protein L11 methyltransferase (PrmA); Region: PrmA; pfam06325 691437002795 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 691437002796 S-adenosylmethionine binding site [chemical binding]; other site 691437002797 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1385; cl00611 691437002798 RNA methyltransferase; Region: Methyltrans_RNA; pfam04452 691437002799 radical SAM methylthiotransferase, MiaB/RimO family; Region: TIGR00089 691437002800 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 691437002801 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 691437002802 FeS/SAM binding site; other site 691437002803 TRAM domain; Region: TRAM; cl01282 691437002804 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 691437002805 intersubunit interface [polypeptide binding]; other site 691437002806 active site 691437002807 catalytic residue [active] 691437002808 Na/Pi-cotransporter; Region: NaPi_cotrn_rel; TIGR00704 691437002809 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 691437002810 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 691437002811 Ribosomal protein S21; Region: Ribosomal_S21; cl00529 691437002812 GatB domain; Region: GatB_Yqey; cl11497 691437002813 YabP family; Region: YabP; cl06766 691437002814 Putative stage IV sporulation protein YqfD; Region: YqfD; pfam06898 691437002815 sporulation protein YqfD; Region: spore_yqfD; TIGR02876 691437002816 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 691437002817 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 691437002818 Predicted membrane-associated HD superfamily hydrolase [General function prediction only]; Region: COG1480 691437002819 7TM receptor with intracellular HD hydrolase; Region: 7TM-7TMR_HD; pfam07698 691437002820 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 691437002821 Zn2+ binding site [ion binding]; other site 691437002822 Mg2+ binding site [ion binding]; other site 691437002823 Uncharacterized protein family UPF0054; Region: UPF0054; cl00402 691437002824 Prokaryotic diacylglycerol kinase; Region: DAGK_prokar; cl00526 691437002825 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 691437002826 active site 691437002827 catalytic motif [active] 691437002828 Zn binding site [ion binding]; other site 691437002829 GTPase Era; Reviewed; Region: era; PRK00089 691437002830 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 691437002831 G1 box; other site 691437002832 GTP/Mg2+ binding site [chemical binding]; other site 691437002833 Switch I region; other site 691437002834 G2 box; other site 691437002835 Switch II region; other site 691437002836 G3 box; other site 691437002837 G4 box; other site 691437002838 G5 box; other site 691437002839 K homology RNA-binding domain, type I. KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains that...; Region: KH-I; cl00098 691437002840 YqzL-like protein; Region: YqzL; pfam14006 691437002841 DNA repair protein RecO; Reviewed; Region: recO; PRK00085 691437002842 Recombination protein O N terminal; Region: RecO_N; cl15812 691437002843 Recombination protein O C terminal; Region: RecO_C; pfam02565 691437002844 Helix-turn-helix domains; Region: HTH; cl00088 691437002845 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_4; cd04617 691437002846 FOG: CBS domain [General function prediction only]; Region: COG0517 691437002847 Kinase/pyrophosphorylase; Region: Kinase-PPPase; cl00780 691437002848 DNA primase; Validated; Region: dnaG; PRK05667 691437002849 CHC2 zinc finger; Region: zf-CHC2; cl15369 691437002850 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 691437002851 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 691437002852 active site 691437002853 metal binding site [ion binding]; metal-binding site 691437002854 interdomain interaction site; other site 691437002855 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 691437002856 RNA polymerase sigma factor RpoD; Validated; Region: PRK09210 691437002857 Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979 691437002858 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 691437002859 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 691437002860 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 691437002861 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 691437002862 DNA binding residues [nucleotide binding] 691437002863 Cytochrome c; Region: Cytochrom_C; cl11414 691437002864 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 691437002865 NIF3 (NGG1p interacting factor 3); Region: NIF3; cl15371 691437002866 NIF3 (NGG1p interacting factor 3); Region: NIF3; cl15371 691437002867 NIF3 (NGG1p interacting factor 3); Region: NIF3; cl15371 691437002868 LytB protein; Region: LYTB; cl00507 691437002869 (E)-4-hydroxy-3-methyl-but-2-enyl pyrophosphate reductase (IPP and DMAPP forming); Region: ispH_lytB; TIGR00216 691437002870 YqfQ-like protein; Region: YqfQ; pfam14181 691437002871 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 691437002872 DEAD-like helicases superfamily; Region: DEXDc; smart00487 691437002873 ATP binding site [chemical binding]; other site 691437002874 Mg++ binding site [ion binding]; other site 691437002875 motif III; other site 691437002876 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 691437002877 nucleotide binding region [chemical binding]; other site 691437002878 ATP-binding site [chemical binding]; other site 691437002879 endonuclease IV; Provisional; Region: PRK01060 691437002880 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019 691437002881 AP (apurinic/apyrimidinic) site pocket; other site 691437002882 DNA interaction; other site 691437002883 Metal-binding active site; metal-binding site 691437002884 Protein of unknown function (DUF2624); Region: DUF2624; pfam11116 691437002885 Uncharacterized conserved protein [Function unknown]; Region: COG1284 691437002886 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 691437002887 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; cl10498 691437002888 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 691437002889 ABC component of the metal-type transporters. This family includes transporters involved in the uptake of various metallic cations such as iron, manganese, and zinc. The ATPases of this group of transporters are very similar to members of...; Region: ABC_Metallic_Cations; cd03235 691437002890 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 691437002891 ABC-ATPase subunit interface; other site 691437002892 dimer interface [polypeptide binding]; other site 691437002893 putative PBP binding regions; other site 691437002894 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 691437002895 metal binding site 2 [ion binding]; metal-binding site 691437002896 putative DNA binding helix; other site 691437002897 metal binding site 1 [ion binding]; metal-binding site 691437002898 dimer interface [polypeptide binding]; other site 691437002899 structural Zn2+ binding site [ion binding]; other site 691437002900 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 691437002901 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366 691437002902 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 691437002903 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 691437002904 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cl00107 691437002905 putative peptidoglycan binding site; other site 691437002906 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 691437002907 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 691437002908 phosphate ABC transporter, permease protein PstC; Region: phosphate_pstC; TIGR02138 691437002909 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 691437002910 dimer interface [polypeptide binding]; other site 691437002911 conserved gate region; other site 691437002912 putative PBP binding loops; other site 691437002913 ABC-ATPase subunit interface; other site 691437002914 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581 691437002915 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 691437002916 dimer interface [polypeptide binding]; other site 691437002917 conserved gate region; other site 691437002918 putative PBP binding loops; other site 691437002919 ABC-ATPase subunit interface; other site 691437002920 Protein of unknown function (DUF1189); Region: DUF1189; pfam06691 691437002921 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 691437002922 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 691437002923 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 691437002924 dimer interface [polypeptide binding]; other site 691437002925 putative CheW interface [polypeptide binding]; other site 691437002926 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 691437002927 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 691437002928 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 691437002929 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 691437002930 putative substrate translocation pore; other site 691437002931 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 691437002932 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 691437002933 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 691437002934 phosphate transporter ATP-binding protein; Provisional; Region: PRK14238 691437002935 Phosphate uptake is of fundamental importance in the cell physiology of bacteria because phosphate is required as a nutrient. The Pst system of E. coli comprises four distinct subunits encoded by the pstS, pstA, pstB, and pstC genes. The PstS protein...; Region: ABC_PstB_phosphate_transporter; cd03260 691437002936 Walker A/P-loop; other site 691437002937 ATP binding site [chemical binding]; other site 691437002938 Q-loop/lid; other site 691437002939 ABC transporter signature motif; other site 691437002940 Walker B; other site 691437002941 D-loop; other site 691437002942 H-loop/switch region; other site 691437002943 proteins similar to Escherichia coli yceG; Region: yceG_like; cl00675 691437002944 Ribosomal protein L33; Region: Ribosomal_L33; cl00383 691437002945 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; cl00360 691437002946 Integral membrane protein DUF92; Region: DUF92; cl00793 691437002947 Rhomboid family; Region: Rhomboid; cl11446 691437002948 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 691437002949 Bacterial protein of unknown function (DUF910); Region: DUF910; cl11543 691437002950 ROK family protein (putative glucokinase); Region: ROK_glcA_fam; TIGR00744 691437002951 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 691437002952 Predicted carboxypeptidase [Amino acid transport and metabolism]; Region: COG2866 691437002953 Peptidase M14 carboxypeptidase family-like domain of Endopeptidase I; Region: M14_Endopeptidase_I; cd06229 691437002954 putative active site [active] 691437002955 Zn binding site [ion binding]; other site 691437002956 Protein of unknown function (DUF2759); Region: DUF2759; pfam10958 691437002957 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 691437002958 Uncharacterized conserved protein [Function unknown]; Region: COG1565 691437002959 Putative S-adenosyl-L-methionine-dependent methyltransferase; Region: Methyltransf_28; pfam02636 691437002960 Protein of unknown function (DUF2626); Region: DUF2626; pfam11117 691437002961 Helix-turn-helix domains; Region: HTH; cl00088 691437002962 Predicted transcriptional regulator [Transcription]; Region: COG2345 691437002963 Type II/IV secretion system protein; Region: T2SE; pfam00437 691437002964 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 691437002965 Walker A motif; other site 691437002966 ATP binding site [chemical binding]; other site 691437002967 Walker B motif; other site 691437002968 Type II secretion system (T2SS), protein F; Region: T2SF; cl00906 691437002969 Type II secretion system (T2SS), protein F; Region: T2SF; cl00906 691437002970 Competence protein ComGC [Intracellular trafficking and secretion]; Region: ComGC; COG4537 691437002971 Competence protein ComGF [Intracellular trafficking and secretion]; Region: ComGF; COG4940 691437002972 ComG operon protein 7; Region: ComGG; pfam14173 691437002973 YqzE-like protein; Region: YqzE; pfam14038 691437002974 Bacterial protein YqhG of unknown function; Region: YqhG; pfam11079 691437002975 SNF2 family N-terminal domain; Region: SNF2_N; pfam00176 691437002976 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 691437002977 ATP binding site [chemical binding]; other site 691437002978 putative Mg++ binding site [ion binding]; other site 691437002979 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 691437002980 nucleotide binding region [chemical binding]; other site 691437002981 ATP-binding site [chemical binding]; other site 691437002982 glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389 691437002983 Sarcosine oxidase, gamma subunit family; Region: SoxG; cl01893 691437002984 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 691437002985 Glycine cleavage system protein P (pyridoxal-binding), N-terminal domain [Amino acid transport and metabolism]; Region: GcvP; COG0403 691437002986 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 691437002987 tetramer interface [polypeptide binding]; other site 691437002988 pyridoxal 5'-phosphate binding site [chemical binding]; other site 691437002989 catalytic residue [active] 691437002990 Glycine cleavage system protein P (pyridoxal-binding), C-terminal domain [Amino acid transport and metabolism]; Region: GcvP; COG1003 691437002991 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 691437002992 tetramer interface [polypeptide binding]; other site 691437002993 pyridoxal 5'-phosphate binding site [chemical binding]; other site 691437002994 catalytic residue [active] 691437002995 Predicted oxidoreductases (related to aryl-alcohol dehydrogenases) [Energy production and conversion]; Region: Tas; COG0667 691437002996 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 691437002997 active site 691437002998 catalytic tetrad [active] 691437002999 Helix-turn-helix domains; Region: HTH; cl00088 691437003000 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 691437003001 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 691437003002 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 691437003003 active site residue [active] 691437003004 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 691437003005 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 691437003006 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK08115 691437003007 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 691437003008 Class II ribonucleotide reductase, dimeric form; Region: RNR_II_dimer; cd02888 691437003009 active site 691437003010 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118 691437003011 putative peptidoglycan binding site; other site 691437003012 Predicted glycosyl hydrolase [General function prediction only]; Region: COG3858 691437003013 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118 691437003014 putative peptidoglycan binding site; other site 691437003015 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118 691437003016 putative peptidoglycan binding site; other site 691437003017 Cortical fragment-lytic enzyme (CFLE) is a peptidoglycan hydrolase involved in bacterial endospore germination. CFLE is expressed as an inactive preprotein (called SleB) in the forespore compartment of sporulating cells. SleB translocates across the...; Region: GH18_CFLE_spore_hydrolase; cd02874 691437003018 active site 691437003019 DNA repair photolyase [DNA replication, recombination, and repair]; Region: SplB; COG1533 691437003020 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 691437003021 FeS/SAM binding site; other site 691437003022 manganese transport transcriptional regulator; Provisional; Region: PRK03902 691437003023 Helix-turn-helix domains; Region: HTH; cl00088 691437003024 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 691437003025 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 691437003026 ExoU and VipD-like proteins; homologus to patatin, cPLA2, and iPLA2; Region: Pat_ExoU_VipD_like; cd07207 691437003027 active site 691437003028 nucleophile elbow; other site 691437003029 Protein of unknown function (DUF1385); Region: DUF1385; cl01595 691437003030 Conserved membrane protein YqhR; Region: YqhR; pfam11085 691437003031 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 691437003032 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 691437003033 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 691437003034 active site 691437003035 elongation factor P; Validated; Region: PRK00529 691437003036 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 691437003037 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 691437003038 RNA binding site [nucleotide binding]; other site 691437003039 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 691437003040 RNA binding site [nucleotide binding]; other site 691437003041 Protein of unknown function (DUF2619); Region: DUF2619; pfam10942 691437003042 stage III sporulation protein AA; Region: spore_III_AA; TIGR02858 691437003043 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 691437003044 Walker A motif; other site 691437003045 ATP binding site [chemical binding]; other site 691437003046 Walker B motif; other site 691437003047 Stage III sporulation protein AB (spore_III_AB); Region: Spore_III_AB; cl08022 691437003048 Stage III sporulation protein AC/AD protein family; Region: SpoIIIAC; cl05961 691437003049 Stage III sporulation protein AC/AD protein family; Region: SpoIIIAC; cl05961 691437003050 Stage III sporulation protein AE (spore_III_AE); Region: Spore_III_AE; cl09771 691437003051 stage III sporulation protein AF; Region: spore_III_AF; TIGR02896 691437003052 Stage III sporulation protein AF (Spore_III_AF); Region: Spore_III_AF; pfam09581 691437003053 stage III sporulation protein AG; Region: spore_III_AG; TIGR02830 691437003054 SpoIIIAH-like protein; Region: SpoIIIAH; pfam12685 691437003055 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302 691437003056 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 691437003057 carboxyltransferase (CT) interaction site; other site 691437003058 biotinylation site [posttranslational modification]; other site 691437003059 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 691437003060 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 691437003061 ATP-grasp domain; Region: ATP-grasp_4; cl03087 691437003062 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; cl08365 691437003063 Asp23 family; Region: Asp23; cl00574 691437003064 Transcription termination factor NusB (N protein-Utilization Substance B). NusB plays a key role in the regulation of ribosomal RNA biosynthesis in eubacteria by modulating the efficiency of transcriptional antitermination. NusB along with other Nus...; Region: Terminator_NusB; cd00619 691437003065 putative RNA binding site [nucleotide binding]; other site 691437003066 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14190 691437003067 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 691437003068 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 691437003069 homodimer interface [polypeptide binding]; other site 691437003070 NADP binding site [chemical binding]; other site 691437003071 substrate binding site [chemical binding]; other site 691437003072 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 691437003073 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 691437003074 generic binding surface II; other site 691437003075 generic binding surface I; other site 691437003076 Exonuclease VII small subunit; Region: Exonuc_VII_S; cl00750 691437003077 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 691437003078 substrate binding pocket [chemical binding]; other site 691437003079 chain length determination region; other site 691437003080 substrate-Mg2+ binding site; other site 691437003081 catalytic residues [active] 691437003082 aspartate-rich region 1; other site 691437003083 active site lid residues [active] 691437003084 aspartate-rich region 2; other site 691437003085 1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444 691437003086 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 691437003087 TPP-binding site; other site 691437003088 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 691437003089 PYR/PP interface [polypeptide binding]; other site 691437003090 dimer interface [polypeptide binding]; other site 691437003091 TPP binding site [chemical binding]; other site 691437003092 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 691437003093 Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189 691437003094 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 691437003095 RNA binding surface [nucleotide binding]; other site 691437003096 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl15754 691437003097 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 691437003098 arginine repressor; Provisional; Region: PRK04280 691437003099 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 691437003100 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497 691437003101 RecN ATPase involved in DNA repair; ABC (ATP-binding cassette) transporter nucleotide-binding domain; ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds including sugars, ions, peptides, and...; Region: ABC_RecN; cd03241 691437003102 Walker A/P-loop; other site 691437003103 ATP binding site [chemical binding]; other site 691437003104 Q-loop/lid; other site 691437003105 RecN ATPase involved in DNA repair; ABC (ATP-binding cassette) transporter nucleotide-binding domain; ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds including sugars, ions, peptides, and...; Region: ABC_RecN; cd03241 691437003106 ABC transporter signature motif; other site 691437003107 Walker B; other site 691437003108 D-loop; other site 691437003109 H-loop/switch region; other site 691437003110 stage IV sporulation protein B; Region: spore_IV_B; TIGR02860 691437003111 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 691437003112 SpoIVB peptidase S55; Region: Peptidase_S55; pfam05580 691437003113 sporulation transcription factor Spo0A; Region: spore_0_A; TIGR02875 691437003114 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 691437003115 active site 691437003116 phosphorylation site [posttranslational modification] 691437003117 intermolecular recognition site; other site 691437003118 dimerization interface [polypeptide binding]; other site 691437003119 Sporulation initiation factor Spo0A C terminal; Region: Spo0A_C; pfam08769 691437003120 YycC-like protein; Region: YycC; pfam14174 691437003121 Glycerophosphodiester phosphodiesterase domain of Thermoanaerobacter tengcongensis and similar proteins; Region: GDPD_TtGDE_like; cd08563 691437003122 Glycerophosphoryl diester phosphodiesterase family; Region: GDPD; pfam03009 691437003123 active site 691437003124 catalytic site [active] 691437003125 metal binding site [ion binding]; metal-binding site 691437003126 dimer interface [polypeptide binding]; other site 691437003127 Protein of unknown function (DUF2627); Region: DUF2627; pfam11118 691437003128 Transcriptional regulator containing PAS, AAA-type ATPase, and DNA-binding domains [Transcription / Signal transduction mechanisms]; Region: RocR; COG3829 691437003129 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 691437003130 putative active site [active] 691437003131 heme pocket [chemical binding]; other site 691437003132 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 691437003133 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 691437003134 Walker A motif; other site 691437003135 ATP binding site [chemical binding]; other site 691437003136 Walker B motif; other site 691437003137 arginine finger; other site 691437003138 Helix-turn-helix domains; Region: HTH; cl00088 691437003139 Phosphate acetyl/butaryl transferase; Region: PTA_PTB; cl00390 691437003140 Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334 691437003141 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 691437003142 NAD(P) binding domain of leucine dehydrogenase, phenylalanine dehydrogenase, and valine dehydrogenase; Region: NAD_bind_Leu_Phe_Val_DH; cd01075 691437003143 NAD binding site [chemical binding]; other site 691437003144 Phe binding site; other site 691437003145 Acetokinase family; Region: Acetate_kinase; cl01029 691437003146 dihydrolipoamide dehydrogenase; Validated; Region: PRK05976 691437003147 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 691437003148 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 691437003149 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 691437003150 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit [Energy production and conversion]; Region: AcoA; COG1071 691437003151 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 691437003152 tetramer interface [polypeptide binding]; other site 691437003153 TPP-binding site [chemical binding]; other site 691437003154 heterodimer interface [polypeptide binding]; other site 691437003155 phosphorylation loop region [posttranslational modification] 691437003156 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 691437003157 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 691437003158 alpha subunit interface [polypeptide binding]; other site 691437003159 TPP binding site [chemical binding]; other site 691437003160 heterodimer interface [polypeptide binding]; other site 691437003161 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 691437003162 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 691437003163 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 691437003164 E3 interaction surface; other site 691437003165 lipoyl attachment site [posttranslational modification]; other site 691437003166 e3 binding domain; Region: E3_binding; pfam02817 691437003167 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; cl02008 691437003168 Uncharacterized conserved protein [Function unknown]; Region: COG3391 691437003169 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 691437003170 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 691437003171 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 691437003172 active site 691437003173 phosphorylation site [posttranslational modification] 691437003174 intermolecular recognition site; other site 691437003175 dimerization interface [polypeptide binding]; other site 691437003176 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 691437003177 DNA binding site [nucleotide binding] 691437003178 heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386 691437003179 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 691437003180 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 691437003181 dimer interface [polypeptide binding]; other site 691437003182 phosphorylation site [posttranslational modification] 691437003183 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 691437003184 ATP binding site [chemical binding]; other site 691437003185 Mg2+ binding site [ion binding]; other site 691437003186 G-X-G motif; other site 691437003187 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 691437003188 putative active site [active] 691437003189 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM) family, Beta subunit-like subfamily; contains bacterial proteins similar to the beta subunit of MCMs from Propionbacterium shermanni and Streptomyces cinnamonensis, which are alpha/beta...; Region: MM_CoA_mutase_beta; cd03677 691437003190 heterodimer interface [polypeptide binding]; other site 691437003191 Methylmalonyl-CoA mutase, N-terminal domain/subunit [Lipid metabolism]; Region: Sbm; COG1884 691437003192 substrate interaction site [chemical binding]; other site 691437003193 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 691437003194 methylmalonyl-CoA mutase; Reviewed; Region: PRK09426 691437003195 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM) family, Alpha subunit-like subfamily; contains proteins similar to the alpha subunit of Propionbacterium shermanni MCM, as well as human and E. coli MCM. Members of this subfamily contain...; Region: MM_CoA_mutase_alpha_like; cd03679 691437003196 active site 691437003197 substrate binding site [chemical binding]; other site 691437003198 coenzyme B12 binding site [chemical binding]; other site 691437003199 methylmalonyl CoA mutase B12 binding domain. This domain binds to B12 (adenosylcobamide), which initiates the conversion of succinyl CoA and methylmalonyl CoA by forming an adenosyl radical, which then undergoes a rearrangement exchanging a hydrogen atom...; Region: MM_CoA_mut_B12_BD; cd02071 691437003200 B12 binding site [chemical binding]; other site 691437003201 cobalt ligand [ion binding]; other site 691437003202 membrane ATPase/protein kinase; Provisional; Region: PRK09435 691437003203 The function of this protein family is unkown. The protein sequences are similar to the ArgK protein in E. coli. ArgK protein is a membrane ATPase which is required for transporting arginine, ornithine and lysine into the cells by the arginine and...; Region: ArgK-like; cd03114 691437003204 Walker A; other site 691437003205 Disulphide isomerase; Region: Disulph_isomer; pfam06491 691437003206 HipA-like C-terminal domain; Region: HipA_C; pfam07804 691437003207 HIRAN domain; Region: HIRAN; cl07418 691437003208 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 691437003209 active site 691437003210 NTP binding site [chemical binding]; other site 691437003211 metal binding triad [ion binding]; metal-binding site 691437003212 antibiotic binding site [chemical binding]; other site 691437003213 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 691437003214 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 691437003215 Walker A/P-loop; other site 691437003216 ATP binding site [chemical binding]; other site 691437003217 Q-loop/lid; other site 691437003218 ABC transporter signature motif; other site 691437003219 Walker B; other site 691437003220 D-loop; other site 691437003221 H-loop/switch region; other site 691437003222 Predicted membrane-associated HD superfamily hydrolase [General function prediction only]; Region: COG1480 691437003223 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 691437003224 ABC-type multidrug transport system, ATPase component. The biological function of this family is not well characterized, but display ABC domains similar to members of ABCA subfamily. ABC transporters are a large family of proteins involved in the...; Region: ABC_drug_resistance_like; cd03264 691437003225 Walker A/P-loop; other site 691437003226 ATP binding site [chemical binding]; other site 691437003227 Q-loop/lid; other site 691437003228 ABC transporter signature motif; other site 691437003229 Walker B; other site 691437003230 D-loop; other site 691437003231 H-loop/switch region; other site 691437003232 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368 691437003233 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 691437003234 Walker A/P-loop; other site 691437003235 ATP binding site [chemical binding]; other site 691437003236 Q-loop/lid; other site 691437003237 ABC transporter signature motif; other site 691437003238 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 691437003239 ABC transporter signature motif; other site 691437003240 Walker B; other site 691437003241 Walker B; other site 691437003242 D-loop; other site 691437003243 D-loop; other site 691437003244 H-loop/switch region; other site 691437003245 Predicted membrane protein [Function unknown]; Region: COG4129 691437003246 Fusaric acid resistance protein-like; Region: FUSC_2; cl15844 691437003247 DUF939 C-terminal domain; Region: DUF939_C; pfam11728 691437003248 L,D-transpeptidase catalytic domain; Region: YkuD; cl15405 691437003249 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 691437003250 Methylmalonyl-CoA epimerase (MMCE); Region: MMCE; cd07249 691437003251 dimer interface [polypeptide binding]; other site 691437003252 substrate binding site [chemical binding]; other site 691437003253 metal binding site [ion binding]; metal-binding site 691437003254 methylmalonyl-CoA decarboxylase alpha subunit; Region: mmdA; TIGR01117 691437003255 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl15772 691437003256 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl15772 691437003257 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 691437003258 B12 binding site [chemical binding]; other site 691437003259 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 691437003260 FeS/SAM binding site; other site 691437003261 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 691437003262 hypothetical protein; Provisional; Region: PRK07206 691437003263 ATP-grasp domain; Region: ATP-grasp_4; cl03087 691437003264 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 691437003265 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 691437003266 G4 box; other site 691437003267 G5 box; other site 691437003268 M20 Peptidase T like enzymes specifically cleave tripeptides; Region: M20_peptT_like; cd05683 691437003269 peptidase T-like protein; Region: PepT-like; TIGR01883 691437003270 metal binding site [ion binding]; metal-binding site 691437003271 putative dimer interface [polypeptide binding]; other site 691437003272 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256 691437003273 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 691437003274 6-phosphogluconate dehydrogenase; Validated; Region: PRK09287 691437003275 6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393 691437003276 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 691437003277 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 691437003278 Walker A/P-loop; other site 691437003279 ATP binding site [chemical binding]; other site 691437003280 Q-loop/lid; other site 691437003281 ABC transporter signature motif; other site 691437003282 Walker B; other site 691437003283 D-loop; other site 691437003284 H-loop/switch region; other site 691437003285 Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal transduction mechanisms]; Region: COG4191 691437003286 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080 691437003287 dimer interface [polypeptide binding]; other site 691437003288 phosphorylation site [posttranslational modification] 691437003289 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 691437003290 ATP binding site [chemical binding]; other site 691437003291 Mg2+ binding site [ion binding]; other site 691437003292 G-X-G motif; other site 691437003293 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 691437003294 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 691437003295 active site 691437003296 phosphorylation site [posttranslational modification] 691437003297 intermolecular recognition site; other site 691437003298 dimerization interface [polypeptide binding]; other site 691437003299 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 691437003300 DNA binding site [nucleotide binding] 691437003301 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 691437003302 Regulators of stationary/sporulation gene expression [Transcription]; Region: AbrB; COG2002 691437003303 Antidote-toxin recognition MazE; Region: Antitoxin-MazE; cl00877 691437003304 Putative cyclase; Region: Cyclase; cl00814 691437003305 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 691437003306 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 691437003307 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 691437003308 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 691437003309 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 691437003310 Old yellow enzyme (OYE) YqjM-like FMN binding domain. YqjM is involved in the oxidative stress response of Bacillus subtilis. Like the other OYE members, each monomer of YqjM contains FMN as a non-covalently bound cofactor and uses NADPH as a reducing...; Region: OYE_YqiM_FMN; cd02932 691437003311 active site 691437003312 FMN binding site [chemical binding]; other site 691437003313 substrate binding site [chemical binding]; other site 691437003314 homotetramer interface [polypeptide binding]; other site 691437003315 catalytic residue [active] 691437003316 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 691437003317 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880 691437003318 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 691437003319 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 691437003320 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 691437003321 NAD(P) binding site [chemical binding]; other site 691437003322 active site 691437003323 YqzH-like protein; Region: YqzH; pfam14164 691437003324 Iron-binding zinc finger CDGSH type; Region: zf-CDGSH; cl02748 691437003325 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4918 691437003326 Protein of unknown function (DUF2552); Region: DUF2552; pfam10827 691437003327 Cyanate permease [Inorganic ion transport and metabolism]; Region: CynX; COG2807 691437003328 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 691437003329 putative substrate translocation pore; other site 691437003330 Predicted oxidoreductases (related to aryl-alcohol dehydrogenases) [Energy production and conversion]; Region: Tas; COG0667 691437003331 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 691437003332 active site 691437003333 catalytic tetrad [active] 691437003334 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 691437003335 dimer interface [polypeptide binding]; other site 691437003336 ADP-ribose binding site [chemical binding]; other site 691437003337 active site 691437003338 nudix motif; other site 691437003339 metal binding site [ion binding]; metal-binding site 691437003340 PHP family phosphoesterase with a Zn ribbon [General function prediction only]; Region: COG1379 691437003341 PHP-associated; Region: PHP_C; pfam13263 691437003342 Integral membrane protein DUF95; Region: DUF95; cl00572 691437003343 ferric uptake regulator; Provisional; Region: fur; PRK09462 691437003344 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 691437003345 metal binding site 2 [ion binding]; metal-binding site 691437003346 putative DNA binding helix; other site 691437003347 metal binding site 1 [ion binding]; metal-binding site 691437003348 dimer interface [polypeptide binding]; other site 691437003349 structural Zn2+ binding site [ion binding]; other site 691437003350 Protein of unknown function (DUF4227); Region: DUF4227; pfam14004 691437003351 site-specific tyrosine recombinase XerD; Reviewed; Region: xerD; PRK00283 691437003352 XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798 691437003353 active site 691437003354 Int/Topo IB signature motif; other site 691437003355 Sulfatase; Region: Sulfatase; cl10460 691437003356 Metalloenzyme superfamily; Region: Metalloenzyme; pfam01676 691437003357 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 691437003358 pyrimidine-nucleoside phosphorylase; Reviewed; Region: PRK06078 691437003359 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 691437003360 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 691437003361 Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; cl06734 691437003362 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 691437003363 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 691437003364 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; cl06814 691437003365 Sulphate Transporter and Anti-Sigma factor antagonist domain found in the C-terminal region of sulphate transporters as well as in bacterial and archaeal proteins involved in the regulation of sigma factors; Region: STAS; cd06844 691437003366 Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms]; Region: RsbW; COG2172 691437003367 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 691437003368 ATP binding site [chemical binding]; other site 691437003369 Mg2+ binding site [ion binding]; other site 691437003370 G-X-G motif; other site 691437003371 sporulation sigma factor SigF; Validated; Region: PRK05572 691437003372 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 691437003373 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 691437003374 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 691437003375 DNA binding residues [nucleotide binding] 691437003376 Stage V sporulation protein AA; Region: SporV_AA; pfam12164 691437003377 Stage V sporulation protein AB; Region: SpoVAB; pfam13782 691437003378 SpoVA protein; Region: SpoVA; cl04298 691437003379 stage V sporulation protein AD; Validated; Region: PRK08304 691437003380 stage V sporulation protein AD; Provisional; Region: PRK12404 691437003381 SpoVA protein; Region: SpoVA; cl04298 691437003382 Stage V sporulation protein AE1; Region: SpoVAE; pfam14097 691437003383 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 691437003384 diaminopimelate decarboxylase; Region: lysA; TIGR01048 691437003385 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 691437003386 active site 691437003387 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 691437003388 substrate binding site [chemical binding]; other site 691437003389 catalytic residues [active] 691437003390 dimer interface [polypeptide binding]; other site 691437003391 Protein of unknown function (DUF1002); Region: DUF1002; pfam06207 691437003392 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 691437003393 active site 691437003394 riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326 691437003395 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 691437003396 catalytic motif [active] 691437003397 Zn binding site [ion binding]; other site 691437003398 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cl00161 691437003399 riboflavin synthase subunit alpha; Provisional; Region: PRK09289 691437003400 Lumazine binding domain; Region: Lum_binding; pfam00677 691437003401 Lumazine binding domain; Region: Lum_binding; pfam00677 691437003402 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09311 691437003403 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; cl00336 691437003404 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 691437003405 dimerization interface [polypeptide binding]; other site 691437003406 active site 691437003407 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 691437003408 homopentamer interface [polypeptide binding]; other site 691437003409 active site 691437003410 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 691437003411 Coenzyme A binding pocket [chemical binding]; other site 691437003412 Domain of unknown function (DUF309); Region: DUF309; cl00667 691437003413 ScpA/B protein; Region: ScpA_ScpB; cl00598 691437003414 Putative transcriptional regulators (Ypuh-like); Region: DUF387; cl00612 691437003415 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 691437003416 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 691437003417 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 691437003418 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 691437003419 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 691437003420 Nucleoside recognition; Region: Gate; cl00486 691437003421 Nucleoside recognition; Region: Gate; cl00486 691437003422 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 691437003423 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 691437003424 RNA binding surface [nucleotide binding]; other site 691437003425 Pseudouridine synthases are responsible for the synthesis of pseudouridine from uracil in ribosomal RNA. The RsuA subfamily includes Pseudouridine Synthase similar to Ribosomal small subunit pseudouridine 516 synthase. Most of the proteins in this...; Region: PseudoU_synth_RsuA_like; cd02870 691437003426 active site 691437003427 periplasmic protein thiol:disulfide oxidoreductases, DsbE subfamily; Region: dsbE; TIGR00385 691437003428 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 691437003429 catalytic residues [active] 691437003430 ResB protein required for cytochrome c biosynthesis [Posttranslational modification, protein turnover, chaperones]; Region: ResB; cl09125 691437003431 ResB-like family; Region: ResB; pfam05140 691437003432 Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504 691437003433 Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504 691437003434 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 691437003435 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 691437003436 active site 691437003437 phosphorylation site [posttranslational modification] 691437003438 intermolecular recognition site; other site 691437003439 dimerization interface [polypeptide binding]; other site 691437003440 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 691437003441 DNA binding site [nucleotide binding] 691437003442 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: VicK; COG5002 691437003443 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 691437003444 dimerization interface [polypeptide binding]; other site 691437003445 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 691437003446 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 691437003447 dimer interface [polypeptide binding]; other site 691437003448 phosphorylation site [posttranslational modification] 691437003449 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 691437003450 ATP binding site [chemical binding]; other site 691437003451 Mg2+ binding site [ion binding]; other site 691437003452 G-X-G motif; other site 691437003453 N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820 691437003454 N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854 691437003455 active site 691437003456 dimer interface [polypeptide binding]; other site 691437003457 GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399 691437003458 active site 691437003459 trimer interface [polypeptide binding]; other site 691437003460 allosteric site; other site 691437003461 active site lid [active] 691437003462 hexamer (dimer of trimers) interface [polypeptide binding]; other site 691437003463 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 691437003464 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 691437003465 DNA-binding site [nucleotide binding]; DNA binding site 691437003466 UTRA domain; Region: UTRA; cl01230 691437003467 PTS system, N-acetylglucosamine-specific IIBC component; Region: PTS-II-BC-nag; TIGR01998 691437003468 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; cl00557 691437003469 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 691437003470 active site turn [active] 691437003471 phosphorylation site [posttranslational modification] 691437003472 Transposase; Region: DEDD_Tnp_IS110; pfam01548 691437003473 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 691437003474 Putative regulator of cell autolysis [Signal transduction mechanisms]; Region: LytS; COG3275 691437003475 Histidine kinase; Region: His_kinase; pfam06580 691437003476 Response regulator receiver domain; Region: Response_reg; pfam00072 691437003477 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 691437003478 active site 691437003479 phosphorylation site [posttranslational modification] 691437003480 intermolecular recognition site; other site 691437003481 dimerization interface [polypeptide binding]; other site 691437003482 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 691437003483 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 691437003484 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 691437003485 Site-specific recombinase; Region: SpecificRecomb; cl15411 691437003486 Acetamidase/Formamidase family; Region: FmdA_AmdA; cl01023 691437003487 Spore germination protein; Region: Spore_permease; cl15802 691437003488 amino acid transporter; Region: 2A0306; TIGR00909 691437003489 Protein of unknown function (DUF1696); Region: DUF1696; pfam08000 691437003490 YvbH-like oligomerisation region; Region: YvbH_ext; pfam11724 691437003491 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883 691437003492 nudix motif; other site 691437003493 Periplasmic binding protein YvrC. These proteins are predicted to function as initial receptors in ABC transport of metal ions in eubacteria and archaea. They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct...; Region: YvrC; cd01143 691437003494 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 691437003495 putative binding site residues; other site 691437003496 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 691437003497 putative PBP binding regions; other site 691437003498 ABC-ATPase subunit interface; other site 691437003499 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 691437003500 ABC transporters, involved in the uptake of siderophores, heme, and vitamin B12, are widely conserved in bacteria and archaea. Only very few species lack representatives of the siderophore family transporters. The E. coli BtuCD protein is an ABC...; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 691437003501 Walker A/P-loop; other site 691437003502 ATP binding site [chemical binding]; other site 691437003503 Q-loop/lid; other site 691437003504 ABC transporter signature motif; other site 691437003505 Walker B; other site 691437003506 D-loop; other site 691437003507 H-loop/switch region; other site 691437003508 Adenosylcobinamide amidohydrolase; Region: CbiZ; cl00808 691437003509 CobD/Cbib protein; Region: CobD_Cbib; cl00561 691437003510 L-threonine-O-3-phosphate decarboxylase; Region: L_thr_O3P_dcar; TIGR01140 691437003511 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 691437003512 pyridoxal 5'-phosphate binding site [chemical binding]; other site 691437003513 homodimer interface [polypeptide binding]; other site 691437003514 catalytic residue [active] 691437003515 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 691437003516 Walker A motif; other site 691437003517 ATP binding site [chemical binding]; other site 691437003518 Walker B motif; other site 691437003519 Cobalamin-5-phosphate synthase; Region: CobS; cl00415 691437003520 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 691437003521 catalytic core [active] 691437003522 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 691437003523 Cobalamin adenosyltransferase; Region: Cob_adeno_trans; cl00920 691437003524 AIR synthase related protein, N-terminal domain; Region: AIRS; pfam00586 691437003525 RNA polymerase sigma factor SigX; Provisional; Region: PRK09639 691437003526 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 691437003527 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 691437003528 DNA binding residues [nucleotide binding] 691437003529 histidinol-phosphatase; Provisional; Region: PRK07328 691437003530 D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK13581 691437003531 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 691437003532 C-terminal ACT (regulatory) domain of D-3-phosphoglycerate dehydrogenase (3PGDH); Region: ACT_3PGDH-xct; cd04902 691437003533 putative L-serine binding site [chemical binding]; other site 691437003534 Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412 691437003535 dimer interface [polypeptide binding]; other site 691437003536 substrate binding site [chemical binding]; other site 691437003537 metal binding sites [ion binding]; metal-binding site 691437003538 4Fe-4S single cluster domain; Region: Fer4_13; pfam13370 691437003539 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4955 691437003540 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 691437003541 ATP binding site [chemical binding]; other site 691437003542 putative Mg++ binding site [ion binding]; other site 691437003543 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 691437003544 nucleotide binding region [chemical binding]; other site 691437003545 ATP-binding site [chemical binding]; other site 691437003546 ATP-dependent RNA helicase DbpA; Provisional; Region: PRK11776 691437003547 ATP-dependent DNA helicase, RecQ family; Region: recQ_fam; TIGR00614 691437003548 CAAX protease self-immunity; Region: Abi; cl00558 691437003549 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118 691437003550 putative peptidoglycan binding site; other site 691437003551 Protein of unknown function (DUF2663); Region: DUF2663; pfam10864 691437003552 Manganese catalase, ferritin-like diiron-binding domain; Region: Mn_catalase; cd01051 691437003553 dimanganese center [ion binding]; other site 691437003554 CotJB protein; Region: CotJB; pfam12652 691437003555 Spore coat associated protein JA (CotJA); Region: CotJA; pfam11007 691437003556 Negative regulator of genetic competence (MecA); Region: MecA; cl02022 691437003557 Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334 691437003558 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 691437003559 NAD(P) binding domain of glutamate dehydrogenase, subgroup 1; Region: NAD_bind_1_Glu_DH; cd01076 691437003560 NAD(P) binding site [chemical binding]; other site 691437003561 putative bacillithiol system oxidoreductase, YpdA family; Region: Bthiol_YpdA; TIGR04018 691437003562 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 691437003563 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 691437003564 Type II (periplasmic) bacterial L-asparaginase; Region: L-asparaginase_II; cd08964 691437003565 active site 691437003566 homotetramer interface [polypeptide binding]; other site 691437003567 homodimer interface [polypeptide binding]; other site 691437003568 Protease prsW family; Region: PrsW-protease; cl15823 691437003569 spore cortex-lytic enzyme; Region: spore_SleB; TIGR02869 691437003570 Putative peptidoglycan binding domain; Region: PG_binding_1; cl15437 691437003571 Cell Wall Hydrolase; Region: Hydrolase_2; pfam07486 691437003572 germination protein YpeB; Region: spore_YpeB; TIGR02889 691437003573 c-di-GMP-binding protein [Signal transduction mechanisms]; Region: COG5581 691437003574 Flagellar protein YcgR; Region: YcgR_2; pfam12945 691437003575 PilZ domain; Region: PilZ; cl01260 691437003576 cytidylate kinase; Provisional; Region: cmk; PRK00023 691437003577 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 691437003578 CMP-binding site; other site 691437003579 The sites determining sugar specificity; other site 691437003580 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 691437003581 putative acyl-acceptor binding pocket; other site 691437003582 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06676 691437003583 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 691437003584 RNA binding site [nucleotide binding]; other site 691437003585 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 691437003586 RNA binding site [nucleotide binding]; other site 691437003587 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 691437003588 RNA binding site [nucleotide binding]; other site 691437003589 S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists of...; Region: S1_RPS1_repeat_hs4; cd05692 691437003590 RNA binding site [nucleotide binding]; other site 691437003591 YpzI-like protein; Region: YpzI; pfam14140 691437003592 YIEGIA protein; Region: YIEGIA; pfam14045 691437003593 GTP-binding protein Der; Reviewed; Region: PRK00093 691437003594 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 691437003595 G1 box; other site 691437003596 GTP/Mg2+ binding site [chemical binding]; other site 691437003597 Switch I region; other site 691437003598 G2 box; other site 691437003599 Switch II region; other site 691437003600 G3 box; other site 691437003601 G4 box; other site 691437003602 G5 box; other site 691437003603 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 691437003604 G1 box; other site 691437003605 GTP/Mg2+ binding site [chemical binding]; other site 691437003606 Switch I region; other site 691437003607 G2 box; other site 691437003608 G3 box; other site 691437003609 Switch II region; other site 691437003610 G4 box; other site 691437003611 G5 box; other site 691437003612 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 691437003613 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 691437003614 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 691437003615 Protein of unknown function (DUF2768); Region: DUF2768; pfam10966 691437003616 Stage IV sporulation protein A (spore_IV_A); Region: Spore_IV_A; cl09772 691437003617 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 691437003618 IHF dimer interface [polypeptide binding]; other site 691437003619 IHF - DNA interface [nucleotide binding]; other site 691437003620 GTP cyclohydrolase I (GTP-CH-I) catalyzes the conversion of GTP into dihydroneopterin triphosphate. The enzyme product is the precursor of tetrahydrofolate in eubacteria, fungi, and plants and of the folate analogs in methanogenic bacteria. In...; Region: GTP_cyclohydro1; cd00642 691437003621 homodecamer interface [polypeptide binding]; other site 691437003622 GTP cyclohydrolase I; Provisional; Region: PLN03044 691437003623 active site 691437003624 putative catalytic site residues [active] 691437003625 zinc binding site [ion binding]; other site 691437003626 GTP-CH-I/GFRP interaction surface; other site 691437003627 Tryptophan RNA-binding attenuator protein; Region: TrpBP; cl03437 691437003628 Heptaprenyl diphosphate synthase (HEPPP synthase) subunit 1; Region: HEPPP_synt_1; pfam07307 691437003629 ubiE/COQ5 methyltransferase family; Region: Ubie_methyltran; pfam01209 691437003630 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 691437003631 S-adenosylmethionine binding site [chemical binding]; other site 691437003632 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 691437003633 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 691437003634 substrate binding pocket [chemical binding]; other site 691437003635 chain length determination region; other site 691437003636 substrate-Mg2+ binding site; other site 691437003637 catalytic residues [active] 691437003638 aspartate-rich region 1; other site 691437003639 active site lid residues [active] 691437003640 aspartate-rich region 2; other site 691437003641 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 691437003642 active site 691437003643 multimer interface [polypeptide binding]; other site 691437003644 Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352 691437003645 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 691437003646 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 691437003647 S-adenosylmethionine binding site [chemical binding]; other site 691437003648 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 691437003649 Tetramer interface [polypeptide binding]; other site 691437003650 active site 691437003651 FMN-binding site [chemical binding]; other site 691437003652 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 691437003653 active site 691437003654 dimer interface [polypeptide binding]; other site 691437003655 metal binding site [ion binding]; metal-binding site 691437003656 Chorismate mutase (AroH) is one of at least five chorismate-utilizing enzymes present in microorganisms that catalyze the rearrangement of chorismate to prephenic acid, the first committed step in the biosynthesis of aromatic amino acids. In prokaryotes; Region: AroH; cd02185 691437003657 homotrimer interaction site [polypeptide binding]; other site 691437003658 active site 691437003659 anthranilate synthase component I; Provisional; Region: PRK13569 691437003660 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 691437003661 chorismate binding enzyme; Region: Chorismate_bind; cl10555 691437003662 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 691437003663 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 691437003664 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 691437003665 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 691437003666 active site 691437003667 ribulose/triose binding site [chemical binding]; other site 691437003668 phosphate binding site [ion binding]; other site 691437003669 substrate (anthranilate) binding pocket [chemical binding]; other site 691437003670 product (indole) binding pocket [chemical binding]; other site 691437003671 Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are monomeric; Region: PRAI; cd00405 691437003672 active site 691437003673 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 691437003674 Pyridoxal-phosphate dependent enzyme; Region: PALP; pfam00291 691437003675 pyridoxal 5'-phosphate binding site [chemical binding]; other site 691437003676 catalytic residue [active] 691437003677 tryptophan synthase subunit alpha; Provisional; Region: trpA; PRK13111 691437003678 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 691437003679 substrate binding site [chemical binding]; other site 691437003680 active site 691437003681 catalytic residues [active] 691437003682 heterodimer interface [polypeptide binding]; other site 691437003683 histidinol-phosphate aminotransferase; Validated; Region: PRK02731 691437003684 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 691437003685 pyridoxal 5'-phosphate binding site [chemical binding]; other site 691437003686 homodimer interface [polypeptide binding]; other site 691437003687 catalytic residue [active] 691437003688 prephenate dehydrogenase; Validated; Region: PRK06545 691437003689 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 691437003690 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 691437003691 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 691437003692 3-phosphoshikimate 1-carboxyvinyltransferase; Region: aroA; TIGR01356 691437003693 hinge; other site 691437003694 active site 691437003695 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 691437003696 binding surface 691437003697 TPR motif; other site 691437003698 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 691437003699 binding surface 691437003700 TPR motif; other site 691437003701 hypothetical protein; Provisional; Region: PRK03636 691437003702 UPF0302 domain; Region: UPF0302; pfam08864 691437003703 IDEAL domain; Region: IDEAL; cl07452 691437003704 Protein of unknown function (DUF2487); Region: DUF2487; pfam10673 691437003705 Rieske Fe-S protein [Energy production and conversion]; Region: QcrA; COG0723 691437003706 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467 691437003707 iron-sulfur cluster [ion binding]; other site 691437003708 [2Fe-2S] cluster binding site [ion binding]; other site 691437003709 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cd00284 691437003710 interchain domain interface [polypeptide binding]; other site 691437003711 intrachain domain interface; other site 691437003712 heme bH binding site [chemical binding]; other site 691437003713 Qi binding site; other site 691437003714 heme bL binding site [chemical binding]; other site 691437003715 Qo binding site; other site 691437003716 Cytochrome b subunit of the bc complex [Energy production and conversion]; Region: QcrB; COG1290 691437003717 Cytochrome b(C-terminus)/b6/petD: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: cytochrome_b_C; cl00193 691437003718 intrachain domain interface; other site 691437003719 Qi binding site; other site 691437003720 Qo binding site; other site 691437003721 Cytochrome c; Region: Cytochrom_C; cl11414 691437003722 Protein of unknown function (DUF1405); Region: DUF1405; cl01798 691437003723 Sporulation protein YpjB (SpoYpjB); Region: Spore_YpjB; cl09800 691437003724 Uncharacterized conserved protein [Function unknown]; Region: COG1284 691437003725 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 691437003726 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 691437003727 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; cl10498 691437003728 MazG nucleotide pyrophosphohydrolase domain; Region: MazG; cl00345 691437003729 dihydrodipicolinate reductase; Provisional; Region: PRK00048 691437003730 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 691437003731 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 691437003732 Methylglyoxal synthase catalyzes the enolization of dihydroxyacetone phosphate (DHAP) to produce methylglyoxal. The first part of the catalytic mechanism is believed to be similar to TIM (triosephosphate isomerase) in that both enzymes utilize DHAP to...; Region: MGS; cd01422 691437003733 active site 691437003734 dimer interfaces [polypeptide binding]; other site 691437003735 catalytic residues [active] 691437003736 GlcNAc-PI de-N-acetylase; Region: PIG-L; cl00929 691437003737 N-acetyl-alpha-D-glucosaminyl L-malate synthase BshA; Region: thiol_BshA; TIGR03999 691437003738 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_5; cd04962 691437003739 tRNA CCA-pyrophosphorylase; Provisional; Region: PRK13299 691437003740 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 691437003741 active site 691437003742 NTP binding site [chemical binding]; other site 691437003743 metal binding triad [ion binding]; metal-binding site 691437003744 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 691437003745 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 691437003746 Helix-turn-helix domains; Region: HTH; cl00088 691437003747 bifunctional biotin--[acetyl-CoA-carboxylase] synthetase/biotin operon repressor; Provisional; Region: PRK11886 691437003748 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 691437003749 Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237 691437003750 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 691437003751 oligomerization interface [polypeptide binding]; other site 691437003752 active site 691437003753 metal binding site [ion binding]; metal-binding site 691437003754 pantoate--beta-alanine ligase; Region: panC; TIGR00018 691437003755 Pantoate-beta-alanine ligase; Region: PanC; cd00560 691437003756 active site 691437003757 ATP-binding site [chemical binding]; other site 691437003758 pantoate-binding site; other site 691437003759 HXXH motif; other site 691437003760 Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919 691437003761 tetramerization interface [polypeptide binding]; other site 691437003762 active site 691437003763 bifunctional ATP-dependent DNA helicase/DNA polymerase III subunit epsilon; Validated; Region: PRK08074 691437003764 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 691437003765 active site 691437003766 catalytic site [active] 691437003767 substrate binding site [chemical binding]; other site 691437003768 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 691437003769 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 691437003770 Protein of unknown function (DUF4264); Region: DUF4264; pfam14084 691437003771 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5353 691437003772 aspartate aminotransferase; Provisional; Region: PRK05764 691437003773 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 691437003774 pyridoxal 5'-phosphate binding site [chemical binding]; other site 691437003775 homodimer interface [polypeptide binding]; other site 691437003776 catalytic residue [active] 691437003777 asparaginyl-tRNA synthetase; Validated; Region: asnC; PRK03932 691437003778 AsnRS_cyto_like_N: N-terminal, anticodon recognition domain of the type found in human and Saccharomyces cerevisiae cytoplasmic asparaginyl-tRNA synthetase (AsnRS), in Brugia malayai AsnRs and, in various putative bacterial AsnRSs. This domain is a...; Region: AsnRS_cyto_like_N; cd04323 691437003779 putative dimer interface [polypeptide binding]; other site 691437003780 putative anticodon binding site; other site 691437003781 Asx tRNA synthetase (AspRS/AsnRS) class II core domain. Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776 691437003782 homodimer interface [polypeptide binding]; other site 691437003783 motif 1; other site 691437003784 motif 2; other site 691437003785 active site 691437003786 motif 3; other site 691437003787 Putative primosome component and related proteins [DNA replication, recombination, and repair]; Region: DnaD; COG3935 691437003788 Replication initiation and membrane attachment; Region: DnaB_2; cl12121 691437003789 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 691437003790 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 691437003791 minor groove reading motif; other site 691437003792 helix-hairpin-helix signature motif; other site 691437003793 substrate binding pocket [chemical binding]; other site 691437003794 active site 691437003795 Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; cl15304 691437003796 Transglycosylase; Region: Transgly; cl07896 691437003797 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 691437003798 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 691437003799 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cl00065 691437003800 Recombination protein U; Region: RecU; cl01314 691437003801 Bacterial domain of unknown function (DUF1798); Region: DUF1798; pfam08807 691437003802 YppF-like protein; Region: YppF; pfam14178 691437003803 YppG-like protein; Region: YppG; pfam14179 691437003804 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 691437003805 putative dimer interface [polypeptide binding]; other site 691437003806 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 691437003807 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 691437003808 active site 691437003809 phosphorylation site [posttranslational modification] 691437003810 intermolecular recognition site; other site 691437003811 dimerization interface [polypeptide binding]; other site 691437003812 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 691437003813 DNA binding site [nucleotide binding] 691437003814 heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386 691437003815 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 691437003816 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 691437003817 dimer interface [polypeptide binding]; other site 691437003818 phosphorylation site [posttranslational modification] 691437003819 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 691437003820 ATP binding site [chemical binding]; other site 691437003821 Mg2+ binding site [ion binding]; other site 691437003822 G-X-G motif; other site 691437003823 Glycerol-3-phosphate responsive antiterminator; Region: G3P_antiterm; cl00852 691437003824 Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578 691437003825 EcsC protein family; Region: EcsC; pfam12787 691437003826 Predicted transcriptional regulator [Transcription]; Region: COG4189 691437003827 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 691437003828 dimerization interface [polypeptide binding]; other site 691437003829 putative DNA binding site [nucleotide binding]; other site 691437003830 putative Zn2+ binding site [ion binding]; other site 691437003831 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 691437003832 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 691437003833 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 691437003834 dimer interface [polypeptide binding]; other site 691437003835 conserved gate region; other site 691437003836 putative PBP binding loops; other site 691437003837 ABC-ATPase subunit interface; other site 691437003838 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 691437003839 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 691437003840 dimer interface [polypeptide binding]; other site 691437003841 conserved gate region; other site 691437003842 putative PBP binding loops; other site 691437003843 ABC-ATPase subunit interface; other site 691437003844 Glycosyl hydrolase family 43; Region: GH43_ABN_2; cd08999 691437003845 putative substrate binding site [chemical binding]; other site 691437003846 active site 691437003847 Glycosyl hydrolase family 43; Region: GH43_2; cd08981 691437003848 active site 691437003849 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; cl08371 691437003850 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 691437003851 Cellulase (glycosyl hydrolase family 5); Region: Cellulase; cl15381 691437003852 Predicted oxidoreductases (related to aryl-alcohol dehydrogenases) [Energy production and conversion]; Region: Tas; COG0667 691437003853 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 691437003854 active site 691437003855 catalytic tetrad [active] 691437003856 galactokinase; Provisional; Region: PRK05322 691437003857 Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509 691437003858 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 691437003859 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 691437003860 UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087 691437003861 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 691437003862 NAD binding site [chemical binding]; other site 691437003863 homodimer interface [polypeptide binding]; other site 691437003864 active site 691437003865 substrate binding site [chemical binding]; other site 691437003866 galactose-1-phosphate uridylyltransferase; Provisional; Region: PRK05270 691437003867 HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the basis...; Region: HIT_like; cl00228 691437003868 HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the basis...; Region: HIT_like; cl00228 691437003869 DNA-binding transcriptional repressor EbgR; Provisional; Region: PRK10339 691437003870 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 691437003871 DNA binding site [nucleotide binding] 691437003872 Ligand-binding domain of DNA transcription repressor GalR which is one of two regulatory proteins involved in galactose transport and metabolism; Region: PBP1_GalR; cd01544 691437003873 putative dimerization interface [polypeptide binding]; other site 691437003874 putative ligand binding site [chemical binding]; other site 691437003875 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 691437003876 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 691437003877 putative dimer interface [polypeptide binding]; other site 691437003878 YqcI/YcgG family; Region: YqcI_YcgG; cl01349 691437003879 Transposase; Region: DEDD_Tnp_IS110; pfam01548 691437003880 LysE type translocator; Region: LysE; cl00565 691437003881 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 691437003882 binding surface 691437003883 TPR motif; other site 691437003884 Thermophilic metalloprotease (M29); Region: Peptidase_M29; pfam02073 691437003885 Sodium:solute symporter family; Region: SSF; cl00456 691437003886 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK08314 691437003887 AMP-binding enzyme; Region: AMP-binding; cl15778 691437003888 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 691437003889 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 691437003890 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl15772 691437003891 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl15772 691437003892 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 691437003893 dimerization interface [polypeptide binding]; other site 691437003894 putative DNA binding site [nucleotide binding]; other site 691437003895 putative Zn2+ binding site [ion binding]; other site 691437003896 Predicted integral membrane protein [Function unknown]; Region: COG5658 691437003897 Protein of unknown function (DUF1648); Region: DUF1648; pfam07853 691437003898 SdpI/YhfL protein family; Region: SdpI; pfam13630 691437003899 Putative membrane peptidase family (DUF2324); Region: DUF2324; cl01810 691437003900 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 691437003901 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_9; cd07245 691437003902 dimer interface [polypeptide binding]; other site 691437003903 putative metal binding site [ion binding]; other site 691437003904 Small acid-soluble spore protein H family; Region: SspH; cl06949 691437003905 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 691437003906 putative active site [active] 691437003907 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 691437003908 putative active site [active] 691437003909 Glutaminase; Region: Glutaminase; cl00907 691437003910 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 691437003911 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 691437003912 Apolipophorin-III precursor (apoLp-III); Region: ApoLp-III; pfam07464 691437003913 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 691437003914 dimer interface [polypeptide binding]; other site 691437003915 conserved gate region; other site 691437003916 putative PBP binding loops; other site 691437003917 ABC-ATPase subunit interface; other site 691437003918 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 691437003919 dimer interface [polypeptide binding]; other site 691437003920 conserved gate region; other site 691437003921 putative PBP binding loops; other site 691437003922 ABC-ATPase subunit interface; other site 691437003923 MoaC_like Similar to the MaoC (monoamine oxidase C) dehydratase regulatory protein but without the N-terminal PutA domain. This protein family has a hot-dog fold similar to that of (R)-specific enoyl-CoA hydratase, the peroxisomal...; Region: MaoC_like; cd03446 691437003924 homodimer interaction site [polypeptide binding]; other site 691437003925 putative active site [active] 691437003926 putative catalytic site [active] 691437003927 metabolite-proton symporter; Region: 2A0106; TIGR00883 691437003928 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 691437003929 putative substrate translocation pore; other site 691437003930 Predicted acetyltransferase [General function prediction only]; Region: COG3153 691437003931 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 691437003932 Coenzyme A binding pocket [chemical binding]; other site 691437003933 conserved hypothetical protein (putative transposase or invertase); Region: T_den_put_tspse; TIGR01784 691437003934 Putative transposase, YhgA-like; Region: Transposase_31; pfam04754 691437003935 Transcriptional regulators [Transcription]; Region: PurR; COG1609 691437003936 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 691437003937 DNA binding site [nucleotide binding] 691437003938 domain linker motif; other site 691437003939 Ligand-binding domain of an uncharacterized transcription regulator from Actinobacillus succinogenes and its close homologs from other bacteria; Region: PBP1_LacI_like_6; cd06284 691437003940 dimerization interface [polypeptide binding]; other site 691437003941 ligand binding site [chemical binding]; other site 691437003942 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 691437003943 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 691437003944 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; cl11611 691437003945 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 691437003946 conserved cys residue [active] 691437003947 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 691437003948 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 691437003949 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 691437003950 AP endonuclease family 2 C terminus; Region: AP_endonuc_2_N; pfam07582 691437003951 Uncharacterized conserved protein [Function unknown]; Region: COG4997 691437003952 N-terminal putative catalytic domain of uncharacterized prokaryotic and archeal HKD family nucleases fused to a DEAD/DEAH box helicase domain; Region: PLDc_N_DEXD_b3; cd09205 691437003953 PLD-like domain; Region: PLDc_2; pfam13091 691437003954 putative homodimer interface [polypeptide binding]; other site 691437003955 putative active site [active] 691437003956 catalytic site [active] 691437003957 Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: HsdR; COG4096 691437003958 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 691437003959 ATP binding site [chemical binding]; other site 691437003960 putative Mg++ binding site [ion binding]; other site 691437003961 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 691437003962 nucleotide binding region [chemical binding]; other site 691437003963 ATP-binding site [chemical binding]; other site 691437003964 CRISPR/Cas system-associated RAMP superfamily protein Cas6; Region: Cas6-I-III; cd09652 691437003965 CRISPR/Cas system-associated protein Cas8a1; Region: Cas8a1_I-A; cl09909 691437003966 CRISPR/Cas system-associated RAMP superfamily protein Cas7; Region: Cas7_I; cl00803 691437003967 CRISPR-associated protein Cas5, subtype I-B/TNEAP; Region: cas_Cas5t; TIGR01895 691437003968 CRISPR/Cas system-associated RAMP superfamily protein Cas5; Region: Cas5_I; cl12040 691437003969 CRISPR/Cas system-associated protein Cas3''; Region: Cas3''_I; cd09641 691437003970 CRISPR-associated helicase Cas3; Region: cas3_core; TIGR01587 691437003971 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 691437003972 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641 691437003973 CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-B; cd09722 691437003974 CRISPR/Cas system-associated protein Cas2; Region: Cas2_I_II_III; cd09725 691437003975 Transposase [DNA replication, recombination, and repair]; Region: COG5421 691437003976 Adenine deaminase [Nucleotide transport and metabolism]; Region: AdeC; COG1001 691437003977 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 691437003978 Adenine deaminase (AdeC) directly deaminates adenine to form hypoxanthine. This reaction is part of one of the adenine salvage pathways, as well as the degradation pathway. It is important for adenine utilization as a purine, as well as a nitrogen source...; Region: AdeC; cd01295 691437003979 active site 691437003980 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 691437003981 Protein of unknown function (DUF4004); Region: DUF4004; pfam13171 691437003982 Polymer-forming cytoskeletal; Region: Bactofilin; pfam04519 691437003983 Polymer-forming cytoskeletal; Region: Bactofilin; pfam04519 691437003984 Integral membrane protein CcmA involved in cell shape determination [Cell envelope biogenesis, outer membrane]; Region: CcmA; COG1664 691437003985 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 691437003986 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 691437003987 putative substrate translocation pore; other site 691437003988 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 691437003989 CoA-disulfide reductase; Region: CoA_CoA_reduc; TIGR03385 691437003990 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 691437003991 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 691437003992 Member of the Rhodanese Homology Domain superfamily. Included in this CD are the Lactococcus lactis NADH oxidase, Bacillus cereus NADH dehydrogenase, and Bacteroides thetaiotaomicron pyridine nucleotide-disulphide oxidoreductase, and similar...; Region: RHOD_Pyr_redox; cd01524 691437003993 active site residue [active] 691437003994 Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446 691437003995 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 691437003996 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 691437003997 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 691437003998 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 691437003999 active site residue [active] 691437004000 PAS domain S-box; Region: sensory_box; TIGR00229 691437004001 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 691437004002 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 691437004003 Histidine kinase; Region: HisKA_3; pfam07730 691437004004 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 691437004005 ATP binding site [chemical binding]; other site 691437004006 Mg2+ binding site [ion binding]; other site 691437004007 G-X-G motif; other site 691437004008 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 691437004009 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 691437004010 active site 691437004011 phosphorylation site [posttranslational modification] 691437004012 intermolecular recognition site; other site 691437004013 dimerization interface [polypeptide binding]; other site 691437004014 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 691437004015 DNA binding residues [nucleotide binding] 691437004016 dimerization interface [polypeptide binding]; other site 691437004017 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; cl00562 691437004018 Cytochrome bd-type quinol oxidase, subunit 2 [Energy production and conversion]; Region: AppB; COG1294 691437004019 Domain of unknown function (DUF202); Region: DUF202; cl09954 691437004020 Predicted glycosyl hydrolase [General function prediction only]; Region: COG3858 691437004021 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118 691437004022 putative peptidoglycan binding site; other site 691437004023 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118 691437004024 putative peptidoglycan binding site; other site 691437004025 Cortical fragment-lytic enzyme (CFLE) is a peptidoglycan hydrolase involved in bacterial endospore germination. CFLE is expressed as an inactive preprotein (called SleB) in the forespore compartment of sporulating cells. SleB translocates across the...; Region: GH18_CFLE_spore_hydrolase; cd02874 691437004026 active site 691437004027 DsrE/DsrF-like family; Region: DrsE; cl00672 691437004028 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 691437004029 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 691437004030 active site residue [active] 691437004031 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 691437004032 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 691437004033 S-adenosylmethionine binding site [chemical binding]; other site 691437004034 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 691437004035 active site residue [active] 691437004036 Uncharacterized protein YrkD from Bacillus subtilis and related domains; this domain superfamily was previously known as part of DUF156; Region: BsYrkD-like_DUF156; cd10155 691437004037 putative homodimer interface [polypeptide binding]; other site 691437004038 putative homotetramer interface [polypeptide binding]; other site 691437004039 putative metal binding site [ion binding]; other site 691437004040 putative homodimer-homodimer interface [polypeptide binding]; other site 691437004041 putative allosteric switch controlling residues; other site 691437004042 SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain. SirA (also known as UvrY, and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291 691437004043 CPxP motif; other site 691437004044 DsrE/DsrF-like family; Region: DrsE; cl00672 691437004045 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 691437004046 active site residue [active] 691437004047 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 691437004048 active site residue [active] 691437004049 SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain. SirA (also known as UvrY, and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291 691437004050 CPxP motif; other site 691437004051 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 691437004052 active site residue [active] 691437004053 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 691437004054 active site residue [active] 691437004055 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 691437004056 Predicted permeases [General function prediction only]; Region: COG0730; cl00498 691437004057 Domain of unknown function DUF302; Region: DUF302; cl01364 691437004058 CobD/Cbib protein; Region: CobD_Cbib; cl00561 691437004059 Fatty acid desaturase [Lipid metabolism]; Region: DesA; COG3239 691437004060 The Delta6 Fatty Acid Desaturase (Delta6-FADS)-like CD includes the integral-membrane enzymes: delta-4, delta-5, delta-6, delta-8, delta-8-sphingolipid, and delta-11 desaturases found in vertebrates, higher plants, fungi, and bacteria. These desaturases...; Region: Delta6-FADS-like; cd03506 691437004061 putative di-iron ligands [ion binding]; other site 691437004062 EamA-like transporter family; Region: EamA; cl01037 691437004063 Plasmid pRiA4b ORF-3-like protein; Region: PRiA4_ORF3; pfam07929 691437004064 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 691437004065 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 691437004066 active site 691437004067 motif I; other site 691437004068 motif II; other site 691437004069 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 691437004070 Citryl-CoA lyase (CCL), the C-terminal portion of the single-subunit type ATP-citrate lyase (ACL) and the C-terminal portion of the large subunit of the two-subunit type ACL. CCL cleaves citryl-CoA (CiCoA) to acetyl-CoA (AcCoA) and oxaloacetate (OAA); Region: CCL_ACL-C; cd06100 691437004071 active site 691437004072 oxalacetate binding site [chemical binding]; other site 691437004073 citrylCoA binding site [chemical binding]; other site 691437004074 coenzyme A binding site [chemical binding]; other site 691437004075 catalytic triad [active] 691437004076 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 691437004077 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 691437004078 NAD(P) binding site [chemical binding]; other site 691437004079 Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase] [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvB; COG0028 691437004080 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 691437004081 PYR/PP interface [polypeptide binding]; other site 691437004082 dimer interface [polypeptide binding]; other site 691437004083 TPP binding site [chemical binding]; other site 691437004084 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; cl00815 691437004085 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cd00568 691437004086 TPP-binding site [chemical binding]; other site 691437004087 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 691437004088 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 691437004089 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441 691437004090 Tripartite ATP-independent periplasmic transporters, DctQ component; Region: DctQ; cl01181 691437004091 C4-dicarboxylate anaerobic carrier; Region: DcuC; cl15356 691437004092 DctM-like transporters; Region: DctM; pfam06808 691437004093 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 691437004094 D-galactonate transporter; Region: 2A0114; TIGR00893 691437004095 putative substrate translocation pore; other site 691437004096 Transcriptional regulator [Transcription]; Region: IclR; COG1414 691437004097 Helix-turn-helix domains; Region: HTH; cl00088 691437004098 Bacterial transcriptional regulator; Region: IclR; pfam01614 691437004099 Type I 3-dehydroquinase, (3-dehydroquinate dehydratase or DHQase); Region: DHQase_I; cd00502 691437004100 3-dehydroquinate dehydratase, type I; Region: aroD; TIGR01093 691437004101 active site 691437004102 catalytic residue [active] 691437004103 dimer interface [polypeptide binding]; other site 691437004104 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 691437004105 CoA-transferase family III; Region: CoA_transf_3; pfam02515 691437004106 Transcriptional regulators [Transcription]; Region: PurR; COG1609 691437004107 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 691437004108 DNA binding site [nucleotide binding] 691437004109 domain linker motif; other site 691437004110 Ligand-binding domain of MalI, a transcription regulator of the maltose system of Escherichia coli and its close homologs from other bacteria; Region: PBP1_MalI_like; cd06289 691437004111 putative dimerization interface [polypeptide binding]; other site 691437004112 putative ligand binding site [chemical binding]; other site 691437004113 shikimate kinase; Reviewed; Region: aroK; PRK00131 691437004114 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 691437004115 ADP binding site [chemical binding]; other site 691437004116 magnesium binding site [ion binding]; other site 691437004117 putative shikimate binding site; other site 691437004118 gp58-like protein; Region: Gp58; pfam07902 691437004119 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl15769 691437004120 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 691437004121 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 691437004122 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 691437004123 Ligand binding site; other site 691437004124 Putative Catalytic site; other site 691437004125 DXD motif; other site 691437004126 GtrA-like protein; Region: GtrA; cl00971 691437004127 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 691437004128 gamma-glutamyl phosphate reductase; Region: proA; TIGR00407 691437004129 putative catalytic cysteine [active] 691437004130 gamma-glutamyl kinase; Provisional; Region: PRK05429 691437004131 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 691437004132 nucleotide binding site [chemical binding]; other site 691437004133 homotetrameric interface [polypeptide binding]; other site 691437004134 putative phosphate binding site [ion binding]; other site 691437004135 putative allosteric binding site; other site 691437004136 PUA domain; Region: PUA; cl00607 691437004137 Dehydratase family; Region: ILVD_EDD; cl00340 691437004138 AMP-binding enzyme; Region: AMP-binding; cl15778 691437004139 phenylacetate-CoA ligase; Region: PA_CoA_ligase; TIGR02155 691437004140 Phenylacetic acid catabolic protein; Region: PaaA_PaaC; cl01346 691437004141 phenylacetate-CoA oxygenase, PaaG subunit; Region: PA_CoA_Oxy1; TIGR02156 691437004142 Phenylacetic acid degradation B; Region: PaaB; cl01371 691437004143 Phenylacetic acid catabolic protein; Region: PaaA_PaaC; cl01346 691437004144 Domain of unknown function DUF59; Region: DUF59; cl00941 691437004145 phenylacetate-CoA oxygenase, PaaJ subunit; Region: PA_CoA_Oxy4; TIGR02159 691437004146 Stress responsive A/B Barrel Domain; Region: Dabb; cl15807 691437004147 enoyl-CoA hydratase; Provisional; Region: PRK05862 691437004148 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 691437004149 substrate binding site [chemical binding]; other site 691437004150 oxyanion hole (OAH) forming residues; other site 691437004151 trimer interface [polypeptide binding]; other site 691437004152 enoyl-CoA hydratase; Provisional; Region: PRK08140 691437004153 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 691437004154 substrate binding site [chemical binding]; other site 691437004155 oxyanion hole (OAH) forming residues; other site 691437004156 trimer interface [polypeptide binding]; other site 691437004157 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 691437004158 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 691437004159 NAD(P) binding site [chemical binding]; other site 691437004160 catalytic residues [active] 691437004161 3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK09260 691437004162 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 691437004163 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 691437004164 putative acyltransferase; Provisional; Region: PRK05790 691437004165 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 691437004166 dimer interface [polypeptide binding]; other site 691437004167 active site 691437004168 PaaX-like protein; Region: PaaX; pfam07848 691437004169 phenylacetic acid degradation operon negative regulatory protein PaaX; Region: PaaX_trns_reg; TIGR02277 691437004170 PaaX-like protein C-terminal domain; Region: PaaX_C; pfam08223 691437004171 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl09108 691437004172 Protein of unknown function (DUF3221); Region: DUF3221; pfam11518 691437004173 Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104 691437004174 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 691437004175 putative substrate translocation pore; other site 691437004176 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cl11420 691437004177 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 691437004178 The N-terminal ATPase domain of the maltose transporter, MalK. ATP binding cassette (ABC) proteins function from bacteria to human, mediating the translocation of substances into and out of cells or organelles. ABC transporters contain two...; Region: ABC_MalK_N; cd03301 691437004179 Walker A/P-loop; other site 691437004180 ATP binding site [chemical binding]; other site 691437004181 Q-loop/lid; other site 691437004182 ABC transporter signature motif; other site 691437004183 Walker B; other site 691437004184 D-loop; other site 691437004185 H-loop/switch region; other site 691437004186 TOBE domain; Region: TOBE_2; cl01440 691437004187 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 691437004188 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 691437004189 dimer interface [polypeptide binding]; other site 691437004190 conserved gate region; other site 691437004191 putative PBP binding loops; other site 691437004192 ABC-ATPase subunit interface; other site 691437004193 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 691437004194 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 691437004195 dimer interface [polypeptide binding]; other site 691437004196 conserved gate region; other site 691437004197 putative PBP binding loops; other site 691437004198 ABC-ATPase subunit interface; other site 691437004199 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 691437004200 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 691437004201 Protein of unknown function (DUF1633); Region: DUF1633; pfam07794 691437004202 Bacterial capsule synthesis protein PGA_cap; Region: PGA_cap; smart00854 691437004203 CapA and related proteins, metallophosphatase domain; Region: MPP_CapA; cd07381 691437004204 putative active site [active] 691437004205 putative metal binding site [ion binding]; other site 691437004206 Sortase D (SrtD) is a membrane transpeptidase found in gram-positive bacteria that anchors surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the surface protein substrate is cleaved...; Region: Sortase_D_4; cd05828 691437004207 active site 691437004208 catalytic site [active] 691437004209 phenylacetate-CoA oxygenase, PaaJ subunit; Region: PA_CoA_Oxy4; TIGR02159 691437004210 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 691437004211 Uncharacterized Candidatus pelagibacter aldehyde dehydrogenase, DhaS-like; Region: ALDH_DhaS; cd07114 691437004212 NAD(P) binding site [chemical binding]; other site 691437004213 catalytic residues [active] 691437004214 PaaX-like protein; Region: PaaX; pfam07848 691437004215 Phenylacetic acid-responsive transcriptional repressor [Transcription]; Region: PaaX; COG3327 691437004216 PaaX-like protein C-terminal domain; Region: PaaX_C; pfam08223 691437004217 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 691437004218 phenylacetate-CoA oxygenase, PaaG subunit; Region: PA_CoA_Oxy1; TIGR02156 691437004219 Phenylacetic acid catabolic protein; Region: PaaA_PaaC; cl01346 691437004220 Domain of unknown function DUF59; Region: DUF59; cl00941 691437004221 Phenylacetic acid degradation B; Region: PaaB; cl01371 691437004222 Phenylacetic acid catabolic protein; Region: PaaA_PaaC; cl01346 691437004223 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 691437004224 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 691437004225 substrate binding site [chemical binding]; other site 691437004226 oxyanion hole (OAH) forming residues; other site 691437004227 trimer interface [polypeptide binding]; other site 691437004228 benzoate-CoA ligase family; Region: benz_CoA_lig; TIGR02262 691437004229 AMP-binding enzyme; Region: AMP-binding; cl15778 691437004230 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 691437004231 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 691437004232 active site 691437004233 Adenine deaminase [Nucleotide transport and metabolism]; Region: AdeC; COG1001 691437004234 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 691437004235 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 691437004236 active site 691437004237 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 691437004238 Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385 691437004239 Membrane transport protein; Region: Mem_trans; cl09117 691437004240 Rhamnogalacturan_acetylesterase_like subgroup of SGNH-hydrolases. Rhamnogalacturan acetylesterase removes acetyl esters from rhamnogalacturonan substrates, and renders them susceptible to degradation by rhamnogalacturonases. Rhamnogalacturonans are...; Region: Rhamnogalacturan_acetylesterase_like; cd01821 691437004241 active site 691437004242 catalytic triad [active] 691437004243 Protein of unknown function (DUF2515); Region: DUF2515; pfam10720 691437004244 This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate...; Region: ISOPREN_C2_like; cl08267 691437004245 squalene-hopene cyclase; Region: hopene_cyclase; TIGR01507 691437004246 Predicted acetyltransferases and hydrolases with the alpha/beta hydrolase fold [General function prediction only]; Region: LipA; COG1075 691437004247 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 691437004248 putative active site [active] 691437004249 PCD_DCoH: The bifunctional protein pterin-4alpha-carbinolamine dehydratase (PCD), also known as DCoH (dimerization cofactor of hepatocyte nuclear factor-1), is both a transcription activator and a metabolic enzyme. DCoH stimulates gene expression by...; Region: PCD_DCoH; cd00488 691437004250 aromatic arch; other site 691437004251 DCoH dimer interaction site [polypeptide binding]; other site 691437004252 DCoH /HNF-1 dimer interaction site [polypeptide binding]; other site 691437004253 DCoH tetramer interaction site [polypeptide binding]; other site 691437004254 substrate binding site [chemical binding]; other site 691437004255 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 691437004256 3-hydroxybutyrate dehydrogenase; Region: PHB_DH; TIGR01963 691437004257 NAD(P) binding site [chemical binding]; other site 691437004258 active site 691437004259 YceI-like domain; Region: YceI; cl01001 691437004260 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 691437004261 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 691437004262 Response regulator receiver domain; Region: Response_reg; pfam00072 691437004263 active site 691437004264 phosphorylation site [posttranslational modification] 691437004265 intermolecular recognition site; other site 691437004266 dimerization interface [polypeptide binding]; other site 691437004267 YcbB domain; Region: YcbB; pfam08664 691437004268 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 691437004269 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 691437004270 ATP binding site [chemical binding]; other site 691437004271 G-X-G motif; other site 691437004272 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 691437004273 dimer interface [polypeptide binding]; other site 691437004274 conserved gate region; other site 691437004275 putative PBP binding loops; other site 691437004276 ABC-ATPase subunit interface; other site 691437004277 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 691437004278 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 691437004279 dimer interface [polypeptide binding]; other site 691437004280 conserved gate region; other site 691437004281 putative PBP binding loops; other site 691437004282 ABC-ATPase subunit interface; other site 691437004283 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 691437004284 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 691437004285 substrate binding pocket [chemical binding]; other site 691437004286 membrane-bound complex binding site; other site 691437004287 hinge residues; other site 691437004288 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 691437004289 HisP and GlnQ are the ATP-binding components of the bacterial periplasmic histidine and glutamine permeases, repectively. Histidine permease is a multisubunit complex containing the HisQ and HisM integral membrane subunits and two copies of HisP. HisP...; Region: ABC_HisP_GlnQ_permeases; cd03262 691437004290 Walker A/P-loop; other site 691437004291 ATP binding site [chemical binding]; other site 691437004292 Q-loop/lid; other site 691437004293 ABC transporter signature motif; other site 691437004294 Walker B; other site 691437004295 D-loop; other site 691437004296 H-loop/switch region; other site 691437004297 Predicted oxidoreductases (related to aryl-alcohol dehydrogenases) [Energy production and conversion]; Region: Tas; COG0667 691437004298 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 691437004299 active site 691437004300 catalytic tetrad [active] 691437004301 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 691437004302 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441 691437004303 Tripartite ATP-independent periplasmic transporters, DctQ component; Region: DctQ; cl01181 691437004304 C4-dicarboxylate anaerobic carrier; Region: DcuC; cl15356 691437004305 DctM-like transporters; Region: DctM; pfam06808 691437004306 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 691437004307 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441 691437004308 Domain of unknown function (DUF2088); Region: DUF2088; cl15406 691437004309 Dehydratase family; Region: ILVD_EDD; cl00340 691437004310 Transcriptional regulator [Transcription]; Region: IclR; COG1414 691437004311 Helix-turn-helix domains; Region: HTH; cl00088 691437004312 Bacterial transcriptional regulator; Region: IclR; pfam01614 691437004313 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 691437004314 Bacillus subtilis NADP+-dependent alpha-ketoglutaric semialdehyde dehydrogenase ycbD-like; Region: ALDH_KGSADH-YcbD; cd07097 691437004315 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 691437004316 NAD(P) binding site [chemical binding]; other site 691437004317 catalytic residues [active] 691437004318 ATP-utilizing enzymes of the PP-loop superfamily [General function prediction only]; Region: COG1606 691437004319 This is a subfamily of Adenine nucleotide alpha hydrolases superfamily. Adenine nucleotide alpha hydrolases superfamily includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which binds to Adenosine group. This subfamily; Region: Alpha_ANH_like_I; cd01990 691437004320 Ligand Binding Site [chemical binding]; other site 691437004321 NCAIR mutase (PurE)-related proteins [General function prediction only]; Region: COG1691 691437004322 AIR carboxylase; Region: AIRC; cl00310 691437004323 Protein of unknown function DUF111; Region: DUF111; cl03398 691437004324 High-affinity nickel-transport protein; Region: NicO; cl00964 691437004325 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 691437004326 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 691437004327 inhibitor site; inhibition site 691437004328 active site 691437004329 dimer interface [polypeptide binding]; other site 691437004330 catalytic residue [active] 691437004331 Peptidase family U32; Region: Peptidase_U32; cl03113 691437004332 SAF domain; Region: SAF; cl00555 691437004333 Altronate dehydratase [Carbohydrate transport and metabolism]; Region: UxaA; COG2721 691437004334 D-galactarate dehydratase / Altronate hydrolase, C terminus; Region: GD_AH_C; pfam04295 691437004335 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 691437004336 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 691437004337 substrate binding site [chemical binding]; other site 691437004338 ATP binding site [chemical binding]; other site 691437004339 2-keto-3-deoxy-6-phosphogluconate aldolase [Carbohydrate transport and metabolism]; Region: Eda; COG0800 691437004340 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 691437004341 active site 691437004342 intersubunit interface [polypeptide binding]; other site 691437004343 catalytic residue [active] 691437004344 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 691437004345 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 691437004346 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 691437004347 Transcriptional regulator containing PAS, AAA-type ATPase, and DNA-binding domains [Transcription / Signal transduction mechanisms]; Region: RocR; COG3829 691437004348 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 691437004349 Walker A motif; other site 691437004350 ATP binding site [chemical binding]; other site 691437004351 Walker B motif; other site 691437004352 arginine finger; other site 691437004353 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 691437004354 Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872 691437004355 active site 691437004356 NAD binding site [chemical binding]; other site 691437004357 metal binding site [ion binding]; metal-binding site 691437004358 Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085 691437004359 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 691437004360 tetrameric interface [polypeptide binding]; other site 691437004361 NAD binding site [chemical binding]; other site 691437004362 catalytic residues [active] 691437004363 Uncharacterized protein family (UPF0175); Region: UPF0175; cl01085 691437004364 Predicted nucleic acid-binding protein, contains PIN domain [General function prediction only]; Region: COG2405 691437004365 Domain of unknown function (DUF3368); Region: DUF3368; pfam11848 691437004366 Phosphotransferase system, mannitol-specific IIBC component [Carbohydrate transport and metabolism]; Region: MtlA; COG2213 691437004367 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; cl00557 691437004368 PTS_IIB_mannitol: subunit IIB of enzyme II (EII) of the mannitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a mannitol-specific permease with two cytoplasmic domains (IIA and IIB) and a transmembrane...; Region: PTS_IIB_mannitol; cd05567 691437004369 active site 691437004370 P-loop; other site 691437004371 phosphorylation site [posttranslational modification] 691437004372 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 691437004373 Helix-turn-helix domains; Region: HTH; cl00088 691437004374 PRD domain; Region: PRD; cl15445 691437004375 PRD domain; Region: PRD; cl15445 691437004376 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 691437004377 active site 691437004378 P-loop; other site 691437004379 phosphorylation site [posttranslational modification] 691437004380 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cl00163 691437004381 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 691437004382 active site 691437004383 phosphorylation site [posttranslational modification] 691437004384 mannitol-1-phosphate 5-dehydrogenase; Provisional; Region: PRK02318 691437004385 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 691437004386 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 691437004387 conserved hypothetical protein (putative transposase or invertase); Region: T_den_put_tspse; TIGR01784 691437004388 Putative transposase, YhgA-like; Region: Transposase_31; pfam04754 691437004389 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 691437004390 NMT1-like family; Region: NMT1_2; cl15260 691437004391 Tripartite tricarboxylate transporter TctB family; Region: TctB; pfam07331 691437004392 Tripartite tricarboxylate transporter TctA family; Region: TctA; cl00772 691437004393 Signal transduction histidine kinase regulating citrate/malate metabolism [Signal transduction mechanisms]; Region: CitA; COG3290 691437004394 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 691437004395 putative active site [active] 691437004396 heme pocket [chemical binding]; other site 691437004397 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 691437004398 ATP binding site [chemical binding]; other site 691437004399 Mg2+ binding site [ion binding]; other site 691437004400 G-X-G motif; other site 691437004401 Response regulator of citrate/malate metabolism [Transcription / Signal transduction mechanisms]; Region: CitB; COG4565 691437004402 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 691437004403 active site 691437004404 phosphorylation site [posttranslational modification] 691437004405 intermolecular recognition site; other site 691437004406 dimerization interface [polypeptide binding]; other site 691437004407 Helix-turn-helix domains; Region: HTH; cl00088 691437004408 Membrane transport protein; Region: Mem_trans; cl09117 691437004409 Putative transposase, YhgA-like; Region: Transposase_31; pfam04754 691437004410 conserved hypothetical protein (putative transposase or invertase); Region: T_den_put_tspse; TIGR01784 691437004411 Transcriptional regulators [Transcription]; Region: PurR; COG1609 691437004412 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 691437004413 DNA binding site [nucleotide binding] 691437004414 domain linker motif; other site 691437004415 Ligand-binding domain of DNA transcription repressor RegR and other putative regulators such as KdgR and EndR; Region: PBP1_RegR_EndR_KdgR_like; cd06283 691437004416 putative dimerization interface [polypeptide binding]; other site 691437004417 putative ligand binding site [chemical binding]; other site 691437004418 gluconate kinase, FGGY type; Region: gntK_FGGY; TIGR01314 691437004419 gluconate kinases; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_GntK; cd07770 691437004420 N- and C-terminal domain interface [polypeptide binding]; other site 691437004421 putative active site [active] 691437004422 carbohydrate binding site [chemical binding]; other site 691437004423 metal binding site [ion binding]; metal-binding site 691437004424 ATP binding site [chemical binding]; other site 691437004425 Na+-H+ antiporter family; Region: Na_H_antiport_2; cl15264 691437004426 GntP family permease; Region: GntP_permease; pfam02447 691437004427 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 691437004428 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 691437004429 dimer interface [polypeptide binding]; other site 691437004430 putative CheW interface [polypeptide binding]; other site 691437004431 Cache domain; Region: Cache_1; pfam02743 691437004432 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 691437004433 Periplasmic component (FmdD) of an active transport system for short-chain amides and urea (FmdDEF); Region: PBP1_FmdD_like; cd06355 691437004434 putative ligand binding site [chemical binding]; other site 691437004435 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 691437004436 TM-ABC transporter signature motif; other site 691437004437 urea ABC transporter, ATP-binding protein UrtD; Region: urea_trans_UrtD; TIGR03411 691437004438 The Mj1267/LivG ABC transporter subfamily is involved in the transport of the hydrophobic amino acids leucine, isoleucine and valine. MJ1267 is a branched-chain amino acid transporter with 29% similarity to both the LivF and LivG components of the E; Region: ABC_Mj1267_LivG_branched; cd03219 691437004439 Walker A/P-loop; other site 691437004440 ATP binding site [chemical binding]; other site 691437004441 Q-loop/lid; other site 691437004442 ABC transporter signature motif; other site 691437004443 Walker B; other site 691437004444 D-loop; other site 691437004445 H-loop/switch region; other site 691437004446 urea ABC transporter, ATP-binding protein UrtE; Region: urea_trans_UrtE; TIGR03410 691437004447 LivF (TM1139) is part of the LIV-I bacterial ABC-type two-component transport system that imports neutral, branched-chain amino acids. The E. coli branched-chain amino acid transporter comprises a heterodimer of ABC transporters (LivF and LivG), a...; Region: ABC_TM1139_LivF_branched; cd03224 691437004448 Walker A/P-loop; other site 691437004449 ATP binding site [chemical binding]; other site 691437004450 Q-loop/lid; other site 691437004451 ABC transporter signature motif; other site 691437004452 Walker B; other site 691437004453 D-loop; other site 691437004454 H-loop/switch region; other site 691437004455 Urease gamma-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use...; Region: Urease_gamma; cd00390 691437004456 alpha-gamma subunit interface [polypeptide binding]; other site 691437004457 beta-gamma subunit interface [polypeptide binding]; other site 691437004458 Urease beta-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use of...; Region: Urease_beta; cd00407 691437004459 gamma-beta subunit interface [polypeptide binding]; other site 691437004460 alpha-beta subunit interface [polypeptide binding]; other site 691437004461 urease subunit alpha; Reviewed; Region: ureC; PRK13207 691437004462 Urease alpha-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, fungi and plants. Their primary role is to allow the use of...; Region: Urease_alpha; cd00375 691437004463 subunit interactions [polypeptide binding]; other site 691437004464 active site 691437004465 flap region; other site 691437004466 urease accessory protein UreE; Provisional; Region: ureE; PRK13261 691437004467 UreE urease accessory protein. UreE is a metallochaperone assisting the insertion of a Ni2+ ion in the active site of urease, an important step in the in vivo assembly of urease, an enzyme that hydrolyses urea into ammonia and carbamic acid. The...; Region: UreE; cd00571 691437004468 dimer interface [polypeptide binding]; other site 691437004469 catalytic residues [active] 691437004470 Urease accessory protein UreF [Posttranslational modification, protein turnover, chaperones]; Region: UreF; COG0830 691437004471 UreF; Region: UreF; pfam01730 691437004472 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 691437004473 UreD urease accessory protein; Region: UreD; cl00530 691437004474 High-affinity nickel-transport protein; Region: NicO; cl00964 691437004475 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 691437004476 Coenzyme A binding pocket [chemical binding]; other site 691437004477 pseudaminic acid biosynthesis N-acetyl transferase; Region: PseH; TIGR03585 691437004478 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 691437004479 Major Facilitator Superfamily; Region: MFS_1; pfam07690 691437004480 putative substrate translocation pore; other site 691437004481 D-Serine dehydratase is a pyridoxal phosphate (PLP)-dependent enzyme which catalyzes the conversion of L- or D-serine to pyruvate and ammonia. D-serine dehydratase serves as a detoxifying enzyme in most E. coli strains where D-serine is a competitive...; Region: D-Ser-dehyd; cd06447 691437004482 Pyridoxal-phosphate dependent enzyme; Region: PALP; pfam00291 691437004483 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 691437004484 catalytic residue [active] 691437004485 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 691437004486 Putative cyclase; Region: Cyclase; cl00814 691437004487 Predicted amidohydrolase [General function prediction only]; Region: COG0388 691437004488 Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cd07197 691437004489 active site 691437004490 catalytic triad [active] 691437004491 dimer interface [polypeptide binding]; other site 691437004492 Sodium:solute symporter family; Region: SSF; cl00456 691437004493 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 691437004494 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 691437004495 NAD(P) binding site [chemical binding]; other site 691437004496 catalytic residues [active] 691437004497 Arginase family; Region: Arginase; cl00306 691437004498 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 691437004499 Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain [Transcription / Signal transduction mechanisms]; Region: PspF; COG1221 691437004500 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 691437004501 Walker A motif; other site 691437004502 ATP binding site [chemical binding]; other site 691437004503 Walker B motif; other site 691437004504 arginine finger; other site 691437004505 Helix-turn-helix domains; Region: HTH; cl00088 691437004506 4-aminobutyrate aminotransferase; Reviewed; Region: PRK06918 691437004507 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 691437004508 inhibitor-cofactor binding pocket; inhibition site 691437004509 pyridoxal 5'-phosphate binding site [chemical binding]; other site 691437004510 catalytic residue [active] 691437004511 4-aminobutyrate aminotransferase; Provisional; Region: PRK08117 691437004512 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 691437004513 inhibitor-cofactor binding pocket; inhibition site 691437004514 pyridoxal 5'-phosphate binding site [chemical binding]; other site 691437004515 catalytic residue [active] 691437004516 Sodium:solute symporter family; Region: SSF; cl00456 691437004517 Uncharacterized ALDH (y4uC) with similarity to Tortula ruralis aldehyde dehydrogenase ALDH21A1; Region: ALDH_y4uC; cd07149 691437004518 NAD(P) binding site [chemical binding]; other site 691437004519 catalytic residues [active] 691437004520 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 691437004521 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl15769 691437004522 enoyl-CoA hydratase; Provisional; Region: PRK07659 691437004523 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 691437004524 substrate binding site [chemical binding]; other site 691437004525 oxyanion hole (OAH) forming residues; other site 691437004526 trimer interface [polypeptide binding]; other site 691437004527 Periplasmic sugar-binding domain of active transport systems that are members of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_sugar_binding_like; cd01536 691437004528 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 691437004529 ligand binding site [chemical binding]; other site 691437004530 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 691437004531 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 691437004532 dimerization interface [polypeptide binding]; other site 691437004533 Histidine kinase; Region: His_kinase; pfam06580 691437004534 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 691437004535 ATP binding site [chemical binding]; other site 691437004536 Mg2+ binding site [ion binding]; other site 691437004537 G-X-G motif; other site 691437004538 Response regulator receiver domain; Region: Response_reg; pfam00072 691437004539 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 691437004540 active site 691437004541 phosphorylation site [posttranslational modification] 691437004542 intermolecular recognition site; other site 691437004543 dimerization interface [polypeptide binding]; other site 691437004544 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 691437004545 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 691437004546 ABC-type xylose transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: XylF; COG4213 691437004547 Periplasmic xylose-binding component of the ABC-type transport systems that belong to a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_xylose_binding; cd01538 691437004548 putative ligand binding site [chemical binding]; other site 691437004549 xylose transporter ATP-binding subunit; Provisional; Region: PRK13549 691437004550 This family represents the domain I of the carbohydrate uptake proteins that transport only monosaccharides (Monos). The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and hexoses...; Region: ABC_Carb_Monos_I; cd03216 691437004551 Walker A/P-loop; other site 691437004552 ATP binding site [chemical binding]; other site 691437004553 Q-loop/lid; other site 691437004554 ABC transporter signature motif; other site 691437004555 Walker B; other site 691437004556 D-loop; other site 691437004557 H-loop/switch region; other site 691437004558 This family represents domain II of the carbohydrate uptake proteins that transport only monosaccharides (Monos). The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and hexoses; Region: ABC_Carb_Monos_II; cd03215 691437004559 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 691437004560 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 691437004561 TM-ABC transporter signature motif; other site 691437004562 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 691437004563 DNA-binding site [nucleotide binding]; DNA binding site 691437004564 Periplasmic binding proteins and sugar binding domain of LacI family; Region: Peripla_BP_1; pfam00532 691437004565 Ligand-binding domain of DNA transcription repressor specific for arabinose (AraR) which is a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_AraR; cd01541 691437004566 putative dimerization interface [polypeptide binding]; other site 691437004567 putative ligand binding site [chemical binding]; other site 691437004568 L-ribulose-5-phosphate 4-epimerase; Reviewed; Region: araD; PRK08193 691437004569 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cd00398 691437004570 intersubunit interface [polypeptide binding]; other site 691437004571 active site 691437004572 Zn2+ binding site [ion binding]; other site 691437004573 ribulokinase; Provisional; Region: PRK04123 691437004574 Ribulokinases; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_RBK; cd07781 691437004575 putative N- and C-terminal domain interface [polypeptide binding]; other site 691437004576 putative active site [active] 691437004577 putative MgATP binding site [chemical binding]; other site 691437004578 catalytic site [active] 691437004579 metal binding site [ion binding]; metal-binding site 691437004580 carbohydrate binding site [chemical binding]; other site 691437004581 homodimer interface [polypeptide binding]; other site 691437004582 L-arabinose isomerase; Provisional; Region: PRK02929 691437004583 L-Arabinose isomerase (AI) catalyzes the isomerization of L-arabinose to L-ribulose, the first reaction in its conversion into D-xylulose-5-phosphate, an intermediate in the pentose phosphate pathway, which allows L-arabinose to be used as a carbon...; Region: L-arabinose_isomerase; cd03557 691437004584 putative hexamer (dimer of trimers) interface [polypeptide binding]; other site 691437004585 trimer interface [polypeptide binding]; other site 691437004586 putative substrate binding site [chemical binding]; other site 691437004587 putative metal binding site [ion binding]; other site 691437004588 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 691437004589 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 691437004590 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 691437004591 dimer interface [polypeptide binding]; other site 691437004592 conserved gate region; other site 691437004593 putative PBP binding loops; other site 691437004594 ABC-ATPase subunit interface; other site 691437004595 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 691437004596 dimer interface [polypeptide binding]; other site 691437004597 conserved gate region; other site 691437004598 putative PBP binding loops; other site 691437004599 ABC-ATPase subunit interface; other site 691437004600 Alpha-L-arabinofuranosidase [Carbohydrate transport and metabolism]; Region: AbfA; COG3534 691437004601 Alpha-L-arabinofuranosidase C-terminus; Region: Alpha-L-AF_C; cl01412 691437004602 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 691437004603 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 691437004604 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; cl11611 691437004605 Galactose mutarotase and related enzymes [Carbohydrate transport and metabolism]; Region: GalM; COG2017 691437004606 galactose mutarotase_like; Region: galactose_mutarotase_like; cd09019 691437004607 active site 691437004608 catalytic residues [active] 691437004609 Predicted sugar phosphatases of the HAD superfamily [Carbohydrate transport and metabolism]; Region: NagD; COG0647 691437004610 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 691437004611 active site 691437004612 motif I; other site 691437004613 motif II; other site 691437004614 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 691437004615 Glycerol-1-phosphate dehydrogenase (G1PDH) catalyzes the reversible reduction of dihydroxyacetone phosphate (DHAP) to glycerol-1-phosphate (G1P) in an NADH-dependent manner; Region: G1PDH; cd08175 691437004616 Glycerol dehydrogenase and related enzymes [Energy production and conversion]; Region: GldA; COG0371 691437004617 active site 691437004618 metal binding site [ion binding]; metal-binding site 691437004619 Probable transposase; Region: OrfB_IS605; pfam01385 691437004620 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 691437004621 Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282 691437004622 Hint module; Region: Hint; pfam01079 691437004623 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 691437004624 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 691437004625 Histidine kinase; Region: His_kinase; pfam06580 691437004626 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 691437004627 ATP binding site [chemical binding]; other site 691437004628 Mg2+ binding site [ion binding]; other site 691437004629 G-X-G motif; other site 691437004630 Response regulator receiver domain; Region: Response_reg; pfam00072 691437004631 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 691437004632 active site 691437004633 phosphorylation site [posttranslational modification] 691437004634 intermolecular recognition site; other site 691437004635 dimerization interface [polypeptide binding]; other site 691437004636 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 691437004637 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 691437004638 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 691437004639 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 691437004640 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 691437004641 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 691437004642 dimer interface [polypeptide binding]; other site 691437004643 putative PBP binding loops; other site 691437004644 ABC-ATPase subunit interface; other site 691437004645 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 691437004646 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 691437004647 dimer interface [polypeptide binding]; other site 691437004648 conserved gate region; other site 691437004649 putative PBP binding loops; other site 691437004650 ABC-ATPase subunit interface; other site 691437004651 Galactose mutarotase and related enzymes [Carbohydrate transport and metabolism]; Region: GalM; COG2017 691437004652 galactose mutarotase_like; Region: galactose_mutarotase_like; cd09019 691437004653 active site 691437004654 catalytic residues [active] 691437004655 Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917 691437004656 NodB motif; other site 691437004657 active site 691437004658 catalytic site [active] 691437004659 metal binding site [ion binding]; metal-binding site 691437004660 Glycosyl hydrolase family 52; Region: Glyco_hydro_52; pfam03512 691437004661 Glycosyl hydrolase family 10; Region: Glyco_hydro_10; cl01495 691437004662 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 691437004663 D-aminoacylase, C-terminal region; Region: D-aminoacyl_C; pfam07908 691437004664 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 691437004665 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 691437004666 dimer interface [polypeptide binding]; other site 691437004667 conserved gate region; other site 691437004668 putative PBP binding loops; other site 691437004669 ABC-ATPase subunit interface; other site 691437004670 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 691437004671 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 691437004672 dimer interface [polypeptide binding]; other site 691437004673 ABC-ATPase subunit interface; other site 691437004674 Alpha-glucuronidase [Carbohydrate transport and metabolism]; Region: AguA; COG3661 691437004675 Glycosyl hydrolase family 67 N-terminus; Region: Glyco_hydro_67N; pfam03648 691437004676 Glycosyl hydrolase family 67 C-terminus; Region: Glyco_hydro_67C; pfam07477 691437004677 Cellulase (glycosyl hydrolase family 5); Region: Cellulase; cl15381 691437004678 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 691437004679 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 691437004680 substrate binding site [chemical binding]; other site 691437004681 ATP binding site [chemical binding]; other site 691437004682 2-keto-3-deoxy-6-phosphogluconate aldolase [Carbohydrate transport and metabolism]; Region: Eda; COG0800 691437004683 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 691437004684 active site 691437004685 intersubunit interface [polypeptide binding]; other site 691437004686 catalytic residue [active] 691437004687 Transcriptional regulators [Transcription]; Region: GntR; COG1802 691437004688 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 691437004689 DNA-binding site [nucleotide binding]; DNA binding site 691437004690 FCD domain; Region: FCD; cl11656 691437004691 Glucuronate isomerase; Region: UxaC; cl00829 691437004692 mannonate dehydratase; Provisional; Region: PRK03906 691437004693 mannonate dehydratase; Region: uxuA; TIGR00695 691437004694 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 691437004695 NAD(P) binding site [chemical binding]; other site 691437004696 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 691437004697 active site 691437004698 Protein of unknown function, DUF624; Region: DUF624; cl02369 691437004699 Glycosyl hydrolase family 10; Region: Glyco_hydro_10; cl01495 691437004700 NIF3 (NGG1p interacting factor 3); Region: NIF3; cl15371 691437004701 SGNH_hydrolase subfamily. SGNH hydrolases are a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site...; Region: SGNH_hydrolase_like_2; cd01834 691437004702 active site 691437004703 catalytic triad [active] 691437004704 oxyanion hole [active] 691437004705 Response regulator containing CheY-like receiver domain and AraC-type DNA-binding domain [Signal transduction mechanisms]; Region: COG4753 691437004706 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 691437004707 active site 691437004708 phosphorylation site [posttranslational modification] 691437004709 intermolecular recognition site; other site 691437004710 dimerization interface [polypeptide binding]; other site 691437004711 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 691437004712 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 691437004713 Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972 691437004714 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 691437004715 Histidine kinase; Region: His_kinase; pfam06580 691437004716 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 691437004717 Mg2+ binding site [ion binding]; other site 691437004718 G-X-G motif; other site 691437004719 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 691437004720 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 691437004721 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 691437004722 dimer interface [polypeptide binding]; other site 691437004723 conserved gate region; other site 691437004724 putative PBP binding loops; other site 691437004725 ABC-ATPase subunit interface; other site 691437004726 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 691437004727 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 691437004728 dimer interface [polypeptide binding]; other site 691437004729 conserved gate region; other site 691437004730 ABC-ATPase subunit interface; other site 691437004731 L-rhamnose isomerase (RhaA); Region: RhaA; cl09945 691437004732 D-xylulose kinases, Escherichia coli xylulokinase-like subgroup; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_D-XK_EcXK-like; cd07808 691437004733 N- and C-terminal domain interface [polypeptide binding]; other site 691437004734 D-xylulose kinase; Region: XylB; TIGR01312 691437004735 active site 691437004736 catalytic site [active] 691437004737 metal binding site [ion binding]; metal-binding site 691437004738 xylulose binding site [chemical binding]; other site 691437004739 putative ATP binding site [chemical binding]; other site 691437004740 homodimer interface [polypeptide binding]; other site 691437004741 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 691437004742 Nitronate monooxygenase; Region: NMO; pfam03060 691437004743 FMN binding site [chemical binding]; other site 691437004744 substrate binding site [chemical binding]; other site 691437004745 putative catalytic residue [active] 691437004746 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 691437004747 Transcriptional regulator containing PAS, AAA-type ATPase, and DNA-binding domains [Transcription / Signal transduction mechanisms]; Region: RocR; COG3829 691437004748 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 691437004749 putative active site [active] 691437004750 heme pocket [chemical binding]; other site 691437004751 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 691437004752 Walker A motif; other site 691437004753 ATP binding site [chemical binding]; other site 691437004754 Walker B motif; other site 691437004755 arginine finger; other site 691437004756 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 691437004757 5-hydroxyvalerate dehydrogenase (HVD) catalyzes the oxidation of 5-hydroxyvalerate to 5-oxovalerate with NAD+ as cofactor; Region: HVD; cd08193 691437004758 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 691437004759 putative active site [active] 691437004760 metal binding site [ion binding]; metal-binding site 691437004761 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 691437004762 active site 691437004763 DnaA N-terminal domain; Region: DnaA_N; pfam11638 691437004764 NAD(P)H-nitrite reductase [Energy production and conversion]; Region: NirB; COG1251 691437004765 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 691437004766 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; cl01093 691437004767 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; cl01093 691437004768 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 691437004769 Small subunit of nitrite reductase (NirD) family, Rieske domain; composed of proteins similar to the Bacillus subtilis small subunit of assimilatory nitrite reductase containing a Rieske domain. The Rieske domain is a [2Fe-2S] cluster binding domain...; Region: Rieske_NirD_small_Bacillus; cd03530 691437004770 [2Fe-2S] cluster binding site [ion binding]; other site 691437004771 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_Nitrate-R-NapA-like; cd02754 691437004772 formate dehydrogenase, alpha subunit, archaeal-type; Region: Fdh-alpha; TIGR01591 691437004773 [4Fe-4S] binding site [ion binding]; other site 691437004774 molybdopterin cofactor binding site; other site 691437004775 This CD includes formate dehydrogenases (Fdh) H and N; nitrate reductases, Nap and Nas; and other related proteins. Formate dehydrogenase H is a component of the anaerobic formate hydrogen lyase complex and catalyzes the reversible oxidation of formate...; Region: MopB_CT_Fdh-Nap-like; cd00508 691437004776 molybdopterin cofactor binding site; other site 691437004777 Nitrate/nitrite transporter [Inorganic ion transport and metabolism]; Region: NarK; COG2223 691437004778 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 691437004779 putative substrate translocation pore; other site 691437004780 Protein of unknown function (DUF3940); Region: DUF3940; pfam13076 691437004781 Helix-Turn-Helix DNA binding domain of GlnR-like transcription regulators; Region: HTH_GlnR-like; cd01105 691437004782 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 691437004783 DNA binding residues [nucleotide binding] 691437004784 putative dimer interface [polypeptide binding]; other site 691437004785 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 691437004786 active site 691437004787 P-loop; other site 691437004788 phosphorylation site [posttranslational modification] 691437004789 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 691437004790 active site 691437004791 methionine cluster; other site 691437004792 phosphorylation site [posttranslational modification] 691437004793 metal binding site [ion binding]; metal-binding site 691437004794 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 691437004795 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; cl00557 691437004796 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 691437004797 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 691437004798 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 691437004799 DNA-binding site [nucleotide binding]; DNA binding site 691437004800 UTRA domain; Region: UTRA; cl01230 691437004801 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 691437004802 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 691437004803 putative active site [active] 691437004804 putative metal binding site [ion binding]; other site 691437004805 Na+/H+ antiporter [Energy production and conversion]; Region: NhaC; COG1757 691437004806 Endonuclease I; Region: Endonuclease_1; cl01003 691437004807 Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385 691437004808 Membrane transport protein; Region: Mem_trans; cl09117 691437004809 FeoA domain; Region: FeoA; cl00838 691437004810 Fe2+ transport system protein B [Inorganic ion transport and metabolism]; Region: FeoB; COG0370 691437004811 Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879 691437004812 G1 box; other site 691437004813 GTP/Mg2+ binding site [chemical binding]; other site 691437004814 Switch I region; other site 691437004815 G2 box; other site 691437004816 G3 box; other site 691437004817 Switch II region; other site 691437004818 G4 box; other site 691437004819 G5 box; other site 691437004820 Nucleoside recognition; Region: Gate; cl00486 691437004821 Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664 691437004822 Nucleoside recognition; Region: Gate; cl00486 691437004823 Fic/DOC family; Region: Fic; cl00960 691437004824 Antidote-toxin recognition MazE; Region: Antitoxin-MazE; cl00877 691437004825 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 691437004826 metal binding site [ion binding]; metal-binding site 691437004827 active site 691437004828 I-site; other site 691437004829 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 691437004830 Zn2+ binding site [ion binding]; other site 691437004831 Mg2+ binding site [ion binding]; other site 691437004832 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 691437004833 Helix-turn-helix domains; Region: HTH; cl00088 691437004834 SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339 691437004835 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105 691437004836 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 691437004837 putative substrate binding site [chemical binding]; other site 691437004838 putative ATP binding site [chemical binding]; other site 691437004839 PTS system 2-O-a-mannosyl-D-glycerate specific transporter subunit IIABC; Provisional; Region: PRK09765 691437004840 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 691437004841 active site 691437004842 phosphorylation site [posttranslational modification] 691437004843 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 691437004844 active site 691437004845 P-loop; other site 691437004846 phosphorylation site [posttranslational modification] 691437004847 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; cl00557 691437004848 Predicted permeases [General function prediction only]; Region: COG0701 691437004849 Predicted permease; Region: DUF318; pfam03773 691437004850 Domain of unknown function (DUF1980); Region: DUF1980; cl01492 691437004851 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 691437004852 Uncharacterized protein family UPF0047; Region: UPF0047; cl00439 691437004853 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 691437004854 active site 691437004855 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 691437004856 dimer interface [polypeptide binding]; other site 691437004857 phosphorylation site [posttranslational modification] 691437004858 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 691437004859 ATP binding site [chemical binding]; other site 691437004860 Mg2+ binding site [ion binding]; other site 691437004861 G-X-G motif; other site 691437004862 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4412 691437004863 Immune inhibitor A peptidase M6; Region: Peptidase_M6; cl11525 691437004864 uroporphyrinogen-III synthase; Reviewed; Region: hemD; PRK05928 691437004865 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 691437004866 active site 691437004867 Hemerythrin (Hr) is a non-heme diiron oxygen transport protein found in four marine invertebrate phyla including priapulida, brachiopoda, sipunculida, and annelida, as well as in protozoa. Myohemerythrin (Mhr), a hemerythrin homolog, is found in the...; Region: Hemerythrin; cl15774 691437004868 Nitrate reductase gamma subunit; Region: Nitrate_red_gam; cl00959 691437004869 Nitrate reductase delta subunit; Region: Nitrate_red_del; cl00958 691437004870 nitrate reductase, beta subunit; Region: narH; TIGR01660 691437004871 respiratory nitrate reductase, alpha subunit; Region: narG; TIGR01580 691437004872 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_Nitrate-R-NarG-like; cd02750 691437004873 [4Fe-4S] binding site [ion binding]; other site 691437004874 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 691437004875 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 691437004876 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 691437004877 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 691437004878 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_CT_Nitrate-R-NarG-like; cd02776 691437004879 molybdopterin cofactor binding site; other site 691437004880 Predicted membrane-bound metal-dependent hydrolase (DUF457); Region: DUF457; cl00868 691437004881 Esterase/lipase [General function prediction only]; Region: COG1647 691437004882 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 691437004883 A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the 'double-glycine' leader peptides from the precursors of various bacteriocins; Region: Peptidase_C39A; cd02549 691437004884 Peptidase_C39 like family; Region: Peptidase_C39_2; pfam13529 691437004885 putative active site [active] 691437004886 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 691437004887 TPR motif; other site 691437004888 type IV pilus biogenesis/stability protein PilW; Region: type_IV_pilW; TIGR02521 691437004889 binding surface 691437004890 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 691437004891 binding surface 691437004892 TPR motif; other site 691437004893 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 691437004894 binding surface 691437004895 TPR motif; other site 691437004896 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 691437004897 binding surface 691437004898 TPR motif; other site 691437004899 Tetratricopeptide repeat; Region: TPR_12; pfam13424 691437004900 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 691437004901 TPR motif; other site 691437004902 binding surface 691437004903 TPR repeat; Region: TPR_11; pfam13414 691437004904 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 691437004905 TPR motif; other site 691437004906 binding surface 691437004907 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 691437004908 TPR motif; other site 691437004909 binding surface 691437004910 TPR repeat; Region: TPR_11; pfam13414 691437004911 60Kd inner membrane protein; Region: 60KD_IMP; cl00489 691437004912 Isochorismatase family; Region: Isochorismatase; pfam00857 691437004913 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 691437004914 catalytic triad [active] 691437004915 conserved cis-peptide bond; other site 691437004916 nicotinate phosphoribosyltransferase; Validated; Region: PRK09243 691437004917 Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570 691437004918 active site 691437004919 oligoendopeptidase F; Region: pepF; TIGR00181 691437004920 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_3; cd09608 691437004921 active site 691437004922 Zn binding site [ion binding]; other site 691437004923 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 691437004924 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 691437004925 active site 691437004926 catalytic tetrad [active] 691437004927 DNA topoisomerase III; Provisional; Region: PRK07726 691437004928 TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362 691437004929 active site 691437004930 putative interdomain interaction site [polypeptide binding]; other site 691437004931 putative metal-binding site [ion binding]; other site 691437004932 putative nucleotide binding site [chemical binding]; other site 691437004933 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 691437004934 domain I; other site 691437004935 DNA binding groove [nucleotide binding] 691437004936 phosphate binding site [ion binding]; other site 691437004937 domain II; other site 691437004938 domain III; other site 691437004939 nucleotide binding site [chemical binding]; other site 691437004940 catalytic site [active] 691437004941 domain IV; other site 691437004942 C-terminal repeat of topoisomerase; Region: Toprim_Crpt; pfam13342 691437004943 Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615 691437004944 Glycerophosphoryl diester phosphodiesterase family; Region: GDPD; pfam03009 691437004945 active site 691437004946 catalytic site [active] 691437004947 Demethylmenaquinone methyltransferase; Region: Methyltransf_6; cl00480 691437004948 Cellular and retroviral pepsin-like aspartate proteases; Region: pepsin_retropepsin_like; cl11403 691437004949 inhibitor binding site; inhibition site 691437004950 catalytic motif [active] 691437004951 Catalytic residue [active] 691437004952 Active site flap [active] 691437004953 Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980 691437004954 dimer interface [polypeptide binding]; other site 691437004955 [2Fe-2S] cluster binding site [ion binding]; other site 691437004956 Cobalt uptake substrate-specific transmembrane region; Region: CbiM; cl00397 691437004957 Cobalt transport protein component CbiN; Region: CbiN; cl00842 691437004958 Cobalt transport protein; Region: CbiQ; cl00463 691437004959 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 691437004960 Domain I of the ABC component of a cobalt transport family found in bacteria, archaea, and eukaryota. The transition metal cobalt is an essential component of many enzymes and must be transported into cells in appropriate amounts when needed. This ABC...; Region: ABC_cobalt_CbiO_domain1; cd03225 691437004961 Walker A/P-loop; other site 691437004962 ATP binding site [chemical binding]; other site 691437004963 Q-loop/lid; other site 691437004964 ABC transporter signature motif; other site 691437004965 Walker B; other site 691437004966 D-loop; other site 691437004967 H-loop/switch region; other site 691437004968 Tetrapyrrole (Corrin/Porphyrin) Methylases; Region: TP_methylase; pfam00590 691437004969 Precorrin-3B methylase [Coenzyme metabolism]; Region: CobJ; cl00304 691437004970 Nitrite and sulphite reductase 4Fe-4S domain; Region: NIR_SIR; pfam01077 691437004971 Sirohydrochlorin ferrochelatase [Inorganic ion transport and metabolism]; Region: COG2138 691437004972 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_N; cd03416 691437004973 putative active site [active] 691437004974 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), C-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_C; cd03414 691437004975 putative active site [active] 691437004976 Precorrin-6x reductase [Coenzyme metabolism]; Region: CobK; COG2099 691437004977 Precorrin-6x reductase CbiJ/CobK; Region: CbiJ; cl00922 691437004978 Precorrin isomerase [Coenzyme metabolism]; Region: CobH; cl00913 691437004979 Precorrin-8X methylmutase; Region: CbiC; pfam02570 691437004980 CbiD; Region: CbiD; cl00828 691437004981 Precorrin-3B methylase [Coenzyme metabolism]; Region: CobJ; cl00304 691437004982 Tetrapyrrole (Corrin/Porphyrin) Methylases; Region: TP_methylase; pfam00590 691437004983 cobalt-precorrin-6Y C(15)-methyltransferase; Validated; Region: PRK08287 691437004984 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl15754 691437004985 Precorrin-3B methylase [Coenzyme metabolism]; Region: CobJ; cl00304 691437004986 Tetrapyrrole (Corrin/Porphyrin) Methylases; Region: TP_methylase; pfam00590 691437004987 Tetrapyrrole (Corrin/Porphyrin) Methylases; Region: TP_methylase; pfam00590 691437004988 Precorrin-3B methylase [Coenzyme metabolism]; Region: CobJ; cl00304 691437004989 cobalamin biosynthesis protein CbiG; Validated; Region: PRK05788 691437004990 Cobalamin synthesis G N-terminal; Region: CbiG_N; pfam11760 691437004991 Cobalamin biosynthesis central region; Region: CbiG_mid; pfam11761 691437004992 Cobalamin synthesis G C-terminus; Region: CbiG_C; cl12133 691437004993 cobyrinic acid a,c-diamide synthase; Validated; Region: PRK01077 691437004994 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 691437004995 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyrinic Acid a,c-Diamide Synthase; Region: GATase1_CobB; cd03130 691437004996 catalytic triad [active] 691437004997 cobyric acid synthase; Provisional; Region: PRK00784 691437004998 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 691437004999 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 691437005000 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 691437005001 catalytic triad [active] 691437005002 Phosphoribosyltransferase; Region: DBI_PRT; pfam02277 691437005003 Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (DMB-PRT), also called CobT; Region: DMB-PRT_CobT; cd02439 691437005004 putative dimer interface [polypeptide binding]; other site 691437005005 active site pocket [active] 691437005006 putative cataytic base [active] 691437005007 Precorrin-3B methylase [Coenzyme metabolism]; Region: CobJ; cl00304 691437005008 Tetrapyrrole (Corrin/Porphyrin) Methylases; Region: TP_methylase; pfam00590 691437005009 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 691437005010 Walker A motif; other site 691437005011 ATP binding site [chemical binding]; other site 691437005012 Walker B motif; other site 691437005013 Homoserine O-succinyltransferase; Region: HTS; pfam04204 691437005014 Type 1 glutamine amidotransferase (GATase1)-like domain found in homoserine trans-succinylase (HTS); Region: GATase1_HTS; cd03131 691437005015 proposed active site lysine [active] 691437005016 conserved cys residue [active] 691437005017 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 691437005018 catalytic residues [active] 691437005019 dimer interface [polypeptide binding]; other site 691437005020 Scaffold protein Nfu/NifU N terminal; Region: Nfu_N; cl07364 691437005021 Virulence factor; Region: Virulence_fact; pfam13769 691437005022 FOG: HEAT repeat [Energy production and conversion]; Region: COG1413 691437005023 PBS lyase HEAT-like repeat; Region: HEAT_PBS; cl15388 691437005024 PBS lyase HEAT-like repeat; Region: HEAT_PBS; cl15388 691437005025 Domain of unknown function (DUF4183); Region: DUF4183; pfam13799 691437005026 Domain of unknown function (DUF4183); Region: DUF4183; pfam13799 691437005027 Disulphide isomerase; Region: Disulph_isomer; pfam06491 691437005028 YuzL-like protein; Region: YuzL; pfam14115 691437005029 aspartate aminotransferase; Provisional; Region: PRK07681 691437005030 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 691437005031 pyridoxal 5'-phosphate binding site [chemical binding]; other site 691437005032 homodimer interface [polypeptide binding]; other site 691437005033 catalytic residue [active] 691437005034 YpjP-like protein; Region: YpjP; pfam14005 691437005035 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 691437005036 dimerization interface [polypeptide binding]; other site 691437005037 active site 691437005038 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 691437005039 folate binding site [chemical binding]; other site 691437005040 NADP+ binding site [chemical binding]; other site 691437005041 Protein of unknown function (DUF2512); Region: DUF2512; pfam10710 691437005042 threonine dehydratase; Validated; Region: PRK08639 691437005043 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 691437005044 tetramer interface [polypeptide binding]; other site 691437005045 pyridoxal 5'-phosphate binding site [chemical binding]; other site 691437005046 catalytic residue [active] 691437005047 Second of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_2; cd04907 691437005048 putative Ile/Val binding site [chemical binding]; other site 691437005049 Protein of unknown function (DUF2535); Region: DUF2535; pfam10751 691437005050 Uncharacterized protein, DegV family COG1307; Region: DegV; cl00577 691437005051 SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968 691437005052 Cu(I) binding site [ion binding]; other site 691437005053 Members of the SGNH-hydrolase superfamily, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_YpmR_like; cd04506 691437005054 active site 691437005055 catalytic triad [active] 691437005056 oxyanion hole [active] 691437005057 Uncharacterized protein conserved in bacteria (DUF2140); Region: DUF2140; cl11548 691437005058 tRNA and rRNA cytosine-C5-methylases [Translation, ribosomal structure and biogenesis]; Region: Sun; COG0144 691437005059 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 691437005060 S-adenosylmethionine binding site [chemical binding]; other site 691437005061 pre-rRNA processing and ribosome biogenesis; Region: Nol1_Nop2_Fmu_2; cl01283 691437005062 Glycerol-3-phosphate acyltransferase; Region: G3P_acyltransf; cl00410 691437005063 OsmC-like protein; Region: OsmC; cl00767 691437005064 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 691437005065 Bacillus subtilis YhcR endonuclease and related proteins, N-terminal metallophosphatase domain; Region: MPP_YhcR_N; cd07412 691437005066 putative active site [active] 691437005067 putative metal binding site [ion binding]; other site 691437005068 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 691437005069 peptidase T; Region: peptidase-T; TIGR01882 691437005070 M20 Peptidase T specifically cleaves tripeptides; Region: M20_peptT; cd03892 691437005071 metal binding site [ion binding]; metal-binding site 691437005072 dimer interface [polypeptide binding]; other site 691437005073 threonine synthase; Validated; Region: PRK08197 691437005074 Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants; Region: Thr-synth_1; cd01563 691437005075 homodimer interface [polypeptide binding]; other site 691437005076 pyridoxal 5'-phosphate binding site [chemical binding]; other site 691437005077 catalytic residue [active] 691437005078 bacterial and archael members of the sulfite oxidase (SO) family of molybdopterin binding domains. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and...; Region: arch_bact_SO_family_Moco; cd02109 691437005079 Moco binding site; other site 691437005080 metal coordination site [ion binding]; other site 691437005081 Protein of unknown function (DUF969); Region: DUF969; cl01573 691437005082 Protein of unknown function (DUF979); Region: DUF979; cl01572 691437005083 Pyroglutamyl peptidase (PGP) type I, also known as pyrrolidone carboxyl peptidase (pcp) type I: Enzymes responsible for cleaving pyroglutamate (pGlu) from the N-terminal end of specialized proteins. The N-terminal pGlu protects these proteins from...; Region: Peptidase_C15; cd00501 691437005084 putative substrate binding pocket [chemical binding]; other site 691437005085 AC domain interface; other site 691437005086 catalytic triad [active] 691437005087 AB domain interface; other site 691437005088 interchain disulfide; other site 691437005089 Predicted membrane protein (DUF2238); Region: DUF2238; cl01464 691437005090 Poly(hydroxyalcanoate) granule associated protein (phasin); Region: Phasin; cl07863 691437005091 Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661 691437005092 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 691437005093 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: APH_ChoK_like; cd05120 691437005094 active site 691437005095 ATP binding site [chemical binding]; other site 691437005096 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 691437005097 DNA gyrase subunit B; Validated; Region: gyrB; PRK05644 691437005098 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 691437005099 ATP binding site [chemical binding]; other site 691437005100 Mg2+ binding site [ion binding]; other site 691437005101 G-X-G motif; other site 691437005102 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 691437005103 anchoring element; other site 691437005104 dimer interface [polypeptide binding]; other site 691437005105 ATP binding site [chemical binding]; other site 691437005106 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 691437005107 active site 691437005108 putative metal-binding site [ion binding]; other site 691437005109 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 691437005110 DNA topoisomerase IV subunit A; Validated; Region: PRK05561 691437005111 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes in DNA...; Region: TOP4c; cd00187 691437005112 CAP-like domain; other site 691437005113 active site 691437005114 primary dimer interface [polypeptide binding]; other site 691437005115 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 691437005116 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 691437005117 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 691437005118 PilZ domain; Region: PilZ; cl01260 691437005119 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 691437005120 Helix-Turn-Helix DNA binding domain of putative MlrA-like transcription regulators; Region: HTH_MlrA-like_sg1; cd04764 691437005121 DNA binding residues [nucleotide binding] 691437005122 PTS system, trehalose-specific IIBC component; Region: PTS-IIBC-Tre; TIGR01992 691437005123 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 691437005124 active site turn [active] 691437005125 phosphorylation site [posttranslational modification] 691437005126 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; cl00557 691437005127 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 691437005128 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 691437005129 Ca binding site [ion binding]; other site 691437005130 active site 691437005131 catalytic site [active] 691437005132 Domain of unknown function (DUF3459); Region: DUF3459; pfam11941 691437005133 trehalose operon repressor, B. subtilis-type; Region: trehalos_R_Bsub; TIGR02404 691437005134 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 691437005135 DNA-binding site [nucleotide binding]; DNA binding site 691437005136 UTRA domain; Region: UTRA; cl01230 691437005137 Na+/H+ antiporter [Energy production and conversion]; Region: NhaC; COG1757 691437005138 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 691437005139 active site 691437005140 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 691437005141 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 691437005142 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 691437005143 catalytic residue [active] 691437005144 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 691437005145 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 691437005146 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 691437005147 spermidine synthase; Provisional; Region: PRK00811 691437005148 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 691437005149 S-adenosylmethionine binding site [chemical binding]; other site 691437005150 Helix-turn-helix domains; Region: HTH; cl00088 691437005151 Rrf2 family protein; Region: rrf2_super; TIGR00738 691437005152 bifunctional nitric oxide dioxygenase/dihydropteridine reductase 2; Provisional; Region: PRK13289 691437005153 Globins are heme proteins, which bind and transport oxygen. This family summarizes a diverse set of homologous protein domains, including: (1) tetrameric vertebrate hemoglobins, which are the major protein component of erythrocytes and transport oxygen...; Region: globin; cd01040 691437005154 heme-binding site [chemical binding]; other site 691437005155 FAD_NAD(P)H binding domain of flavohemoglobin. Flavohemoglobins have a globin domain containing a B-type heme fused with a ferredoxin reductase-like FAD/NAD-binding domain. Flavohemoglobins detoxify nitric oxide (NO) via an NO dioxygenase reaction. The...; Region: flavohem_like_fad_nad_binding; cd06184 691437005156 FAD binding pocket [chemical binding]; other site 691437005157 FAD binding motif [chemical binding]; other site 691437005158 phosphate binding motif [ion binding]; other site 691437005159 beta-alpha-beta structure motif; other site 691437005160 NAD binding pocket [chemical binding]; other site 691437005161 Heme binding pocket [chemical binding]; other site 691437005162 formyltetrahydrofolate deformylase; Reviewed; Region: purU; PRK06027 691437005163 N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875 691437005164 Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648 691437005165 putative active site [active] 691437005166 putative substrate binding site [chemical binding]; other site 691437005167 putative cosubstrate binding site; other site 691437005168 catalytic site [active] 691437005169 Replication terminator protein; Region: RTP; pfam02334 691437005170 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 691437005171 Walker A motif; other site 691437005172 ATP binding site [chemical binding]; other site 691437005173 AAA ATPase containing von Willebrand factor type A (vWA) domain [General function prediction only]; Region: MDN1; COG5271 691437005174 Walker B motif; other site 691437005175 arginine finger; other site 691437005176 Nitric oxide reductase activation protein [Inorganic ion transport and metabolism]; Region: NorD; COG4548 691437005177 norD type: Denitrifying bacteria contain both membrane bound and periplasmic nitrate reductases. Denitrification plays a major role in completing the nitrogen cycle by converting nitrate or nitrite to nitrogen gas. The pathway for microbial...; Region: vWA_norD_type; cd01454 691437005178 metal ion-dependent adhesion site (MIDAS); other site 691437005179 Predicted phosphohydrolase (DHH superfamily) [General function prediction only]; Region: COG2404 691437005180 DHH family; Region: DHH; pfam01368 691437005181 Peptidase family M23; Region: Peptidase_M23; pfam01551 691437005182 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 691437005183 nudix motif; other site 691437005184 catalase/hydroperoxidase HPI(I); Provisional; Region: PRK15061 691437005185 N-terminal catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_1; cd00649 691437005186 dimer interface [polypeptide binding]; other site 691437005187 active site 691437005188 heme binding site [chemical binding]; other site 691437005189 C-terminal non-catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_2; cd08200 691437005190 H+ Antiporter protein; Region: 2A0121; TIGR00900 691437005191 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 691437005192 putative substrate translocation pore; other site 691437005193 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 691437005194 LysE type translocator; Region: LysE; cl00565 691437005195 Predicted membrane protein [Function unknown]; Region: COG3428 691437005196 Bacterial PH domain; Region: DUF304; cl01348 691437005197 Bacterial PH domain; Region: DUF304; cl01348 691437005198 Bacterial PH domain; Region: DUF304; cl01348 691437005199 Bacterial PH domain; Region: DUF304; cl01348 691437005200 Protein of unknown function (DUF1541); Region: DUF1541; pfam07563 691437005201 Protein of unknown function (DUF1541); Region: DUF1541; pfam07563 691437005202 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 691437005203 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 691437005204 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 691437005205 active site 691437005206 phosphorylation site [posttranslational modification] 691437005207 intermolecular recognition site; other site 691437005208 dimerization interface [polypeptide binding]; other site 691437005209 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 691437005210 DNA binding site [nucleotide binding] 691437005211 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 691437005212 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 691437005213 dimerization interface [polypeptide binding]; other site 691437005214 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 691437005215 dimer interface [polypeptide binding]; other site 691437005216 phosphorylation site [posttranslational modification] 691437005217 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 691437005218 ATP binding site [chemical binding]; other site 691437005219 Mg2+ binding site [ion binding]; other site 691437005220 G-X-G motif; other site 691437005221 DNA topoisomerase III; Provisional; Region: PRK07726 691437005222 TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362 691437005223 active site 691437005224 putative interdomain interaction site [polypeptide binding]; other site 691437005225 putative metal-binding site [ion binding]; other site 691437005226 putative nucleotide binding site [chemical binding]; other site 691437005227 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 691437005228 domain I; other site 691437005229 DNA binding groove [nucleotide binding] 691437005230 phosphate binding site [ion binding]; other site 691437005231 domain II; other site 691437005232 domain III; other site 691437005233 nucleotide binding site [chemical binding]; other site 691437005234 catalytic site [active] 691437005235 domain IV; other site 691437005236 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 691437005237 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 691437005238 Catalytic domain of Protein Kinases; Region: PKc; cd00180 691437005239 active site 691437005240 ATP binding site [chemical binding]; other site 691437005241 substrate binding site [chemical binding]; other site 691437005242 activation loop (A-loop); other site 691437005243 enoyl-CoA hydratase; Provisional; Region: PRK06688 691437005244 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 691437005245 substrate binding site [chemical binding]; other site 691437005246 oxyanion hole (OAH) forming residues; other site 691437005247 trimer interface [polypeptide binding]; other site 691437005248 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 691437005249 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 691437005250 NAD(P) binding site [chemical binding]; other site 691437005251 active site 691437005252 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 691437005253 classical (c) SDRs; Region: SDR_c; cd05233 691437005254 NAD(P) binding site [chemical binding]; other site 691437005255 active site 691437005256 Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; cl05194 691437005257 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 691437005258 Domain I of the ABC component of a cobalt transport family found in bacteria, archaea, and eukaryota. The transition metal cobalt is an essential component of many enzymes and must be transported into cells in appropriate amounts when needed. This ABC...; Region: ABC_cobalt_CbiO_domain1; cd03225 691437005259 Walker A/P-loop; other site 691437005260 ATP binding site [chemical binding]; other site 691437005261 Q-loop/lid; other site 691437005262 ABC transporter signature motif; other site 691437005263 Walker B; other site 691437005264 D-loop; other site 691437005265 H-loop/switch region; other site 691437005266 Nitric oxide synthase (NOS) prokaryotic oxygenase domain. NOS produces nitric oxide (NO) by catalyzing a five-electron heme-based oxidation of a guanidine nitrogen of L-arginine to L-citrulline via two successive monooxygenation reactions producing N...; Region: NOS_oxygenase_prok; cd00794 691437005267 active site 691437005268 dimer interface [polypeptide binding]; other site 691437005269 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 691437005270 ABC-2 type transporter; Region: ABC2_membrane; cl11417 691437005271 Protein of unknown function, DUF606; Region: DUF606; cl01273 691437005272 Chromate transporter; Region: Chromate_transp; pfam02417 691437005273 chromate transporter, chromate ion transporter (CHR) family; Region: 2A51; TIGR00937 691437005274 Chromate transporter; Region: Chromate_transp; pfam02417 691437005275 QueT transporter; Region: QueT; cl01932 691437005276 EamA-like transporter family; Region: EamA; cl01037 691437005277 OsmC-like protein; Region: OsmC; cl00767 691437005278 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 691437005279 Type I periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type active transport systems that are predicted to be involved in transport of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_3; cd06336 691437005280 putative ligand binding site [chemical binding]; other site 691437005281 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 691437005282 LivF (TM1139) is part of the LIV-I bacterial ABC-type two-component transport system that imports neutral, branched-chain amino acids. The E. coli branched-chain amino acid transporter comprises a heterodimer of ABC transporters (LivF and LivG), a...; Region: ABC_TM1139_LivF_branched; cd03224 691437005283 Walker A/P-loop; other site 691437005284 ATP binding site [chemical binding]; other site 691437005285 Q-loop/lid; other site 691437005286 ABC transporter signature motif; other site 691437005287 Walker B; other site 691437005288 D-loop; other site 691437005289 H-loop/switch region; other site 691437005290 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 691437005291 The Mj1267/LivG ABC transporter subfamily is involved in the transport of the hydrophobic amino acids leucine, isoleucine and valine. MJ1267 is a branched-chain amino acid transporter with 29% similarity to both the LivF and LivG components of the E; Region: ABC_Mj1267_LivG_branched; cd03219 691437005292 Walker A/P-loop; other site 691437005293 ATP binding site [chemical binding]; other site 691437005294 Q-loop/lid; other site 691437005295 ABC transporter signature motif; other site 691437005296 Walker B; other site 691437005297 D-loop; other site 691437005298 H-loop/switch region; other site 691437005299 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 691437005300 TM-ABC transporter signature motif; other site 691437005301 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 691437005302 TM-ABC transporter signature motif; other site 691437005303 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 691437005304 Helix-turn-helix domains; Region: HTH; cl00088 691437005305 putative acyltransferase; Provisional; Region: PRK05790 691437005306 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 691437005307 dimer interface [polypeptide binding]; other site 691437005308 active site 691437005309 SAV4209_like. Similar in sequence to the Streptomyces avermitilis SAV4209 protein, with a hot dog fold that is similar to those of (R)-specific enoyl-CoA hydratase, the peroxisomal Hydratase-Dehydrogenase-Epimerase (HDE) protein, and the fatty acid...; Region: SAV4209_like; cd03453 691437005310 active site 691437005311 catalytic site [active] 691437005312 (R)-hydratase [(R)-specific enoyl-CoA hydratase]. Catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. The structure of the monomer includes a five-strand antiparallel...; Region: R_hydratase_like; cd03441 691437005313 active site 691437005314 catalytic site [active] 691437005315 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 691437005316 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 691437005317 NAD(P) binding site [chemical binding]; other site 691437005318 active site 691437005319 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 691437005320 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 691437005321 active site 691437005322 NAD-dependent deacetylase; Provisional; Region: PRK00481 691437005323 SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2; cl00195 691437005324 This family contains NADPH-dependent flavin reductase and oxygen-insensitive nitroreductase. These enzymes are homodimeric flavoproteins that contain one FMN per monomer as a cofactor. Flavin reductase catalyzes the reduction of flavin by using NADPH as...; Region: NfsA_FRP; cd02146 691437005325 dimer interface [polypeptide binding]; other site 691437005326 FMN binding site [chemical binding]; other site 691437005327 NADPH bind site [chemical binding]; other site 691437005328 Pirin-related protein [General function prediction only]; Region: COG1741 691437005329 Cupin domain; Region: Cupin_2; cl09118 691437005330 Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726 691437005331 PemK-like protein; Region: PemK; cl00995 691437005332 Antidote-toxin recognition MazE; Region: Antitoxin-MazE; cl00877 691437005333 Probable transposase; Region: OrfB_IS605; pfam01385 691437005334 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 691437005335 Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282 691437005336 ABC-2 type transporter; Region: ABC2_membrane; cl11417 691437005337 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 691437005338 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 691437005339 Walker A/P-loop; other site 691437005340 ATP binding site [chemical binding]; other site 691437005341 Q-loop/lid; other site 691437005342 ABC transporter signature motif; other site 691437005343 Walker B; other site 691437005344 D-loop; other site 691437005345 H-loop/switch region; other site 691437005346 Members of the SGNH-hydrolase superfamily, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_YpmR_like; cd04506 691437005347 active site 691437005348 catalytic triad [active] 691437005349 oxyanion hole [active] 691437005350 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 691437005351 Predicted permeases [General function prediction only]; Region: COG0730; cl00498 691437005352 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 691437005353 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 691437005354 glutamine synthetase, type I; Region: GlnA; TIGR00653 691437005355 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 691437005356 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 691437005357 putative active site pocket [active] 691437005358 dimerization interface [polypeptide binding]; other site 691437005359 putative catalytic residue [active] 691437005360 Peroxiredoxin (PRX)-like 1 family; hypothetical proteins that show sequence similarity to PRXs. Members of this group contain a conserved cysteine that aligns to the first cysteine in the CXXC motif of TRX. This does not correspond to the peroxidatic...; Region: PRX_like1; cd02969 691437005361 putative catalytic residue [active] 691437005362 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 691437005363 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141 691437005364 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2258 691437005365 MOSC domain; Region: MOSC; pfam03473 691437005366 3-alpha domain; Region: 3-alpha; pfam03475 691437005367 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 691437005368 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 691437005369 Glucan exporter ATP-binding protein. In A. tumefaciens cyclic beta-1, 2-glucan must be transported into the periplasmic space to exert its action as a virluence factor. This subfamily belongs to the MRP-like family and is involved in drug, peptide, and...; Region: ABCC_Glucan_exporter_like; cd03254 691437005370 Walker A/P-loop; other site 691437005371 ATP binding site [chemical binding]; other site 691437005372 Q-loop/lid; other site 691437005373 ABC transporter signature motif; other site 691437005374 Walker B; other site 691437005375 D-loop; other site 691437005376 H-loop/switch region; other site 691437005377 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 691437005378 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 691437005379 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 691437005380 Walker A/P-loop; other site 691437005381 ATP binding site [chemical binding]; other site 691437005382 Q-loop/lid; other site 691437005383 ABC transporter signature motif; other site 691437005384 Walker B; other site 691437005385 D-loop; other site 691437005386 H-loop/switch region; other site 691437005387 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 691437005388 anti sigma factor interaction site; other site 691437005389 regulatory phosphorylation site [posttranslational modification]; other site 691437005390 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 691437005391 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 691437005392 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 691437005393 putative active site [active] 691437005394 heme pocket [chemical binding]; other site 691437005395 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 691437005396 PAS domain; Region: PAS_9; pfam13426 691437005397 Sigma factor PP2C-like phosphatases; Region: PP2C_SIG; smart00331 691437005398 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cl00120 691437005399 Spore germination protein; Region: Spore_permease; cl15802 691437005400 Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; cl05194 691437005401 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 691437005402 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 691437005403 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 691437005404 This family of ATP-binding proteins belongs to a multisubunit transporter involved in drug resistance (BcrA and DrrA), nodulation, lipid transport, and lantibiotic immunity. In bacteria and archaea, these transporters usually include an ATP-binding...; Region: ABC_DR_subfamily_A; cd03230 691437005405 Walker A/P-loop; other site 691437005406 ATP binding site [chemical binding]; other site 691437005407 Q-loop/lid; other site 691437005408 ABC transporter signature motif; other site 691437005409 Walker B; other site 691437005410 D-loop; other site 691437005411 H-loop/switch region; other site 691437005412 Predicted transcriptional regulators [Transcription]; Region: COG1725 691437005413 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 691437005414 DNA-binding site [nucleotide binding]; DNA binding site 691437005415 Protein of unknown function (DUF421); Region: DUF421; cl00990 691437005416 Spore germination protein; Region: Spore_permease; cl15802 691437005417 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 691437005418 Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; cl05194 691437005419 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 691437005420 dimer interface [polypeptide binding]; other site 691437005421 phosphorylation site [posttranslational modification] 691437005422 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 691437005423 ATP binding site [chemical binding]; other site 691437005424 Mg2+ binding site [ion binding]; other site 691437005425 G-X-G motif; other site 691437005426 tropinone reductase; Provisional; Region: PRK09242 691437005427 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 691437005428 NAD(P) binding site [chemical binding]; other site 691437005429 active site 691437005430 NETI protein; Region: NETI; pfam14044 691437005431 Protein of unknown function (DUF2639); Region: DUF2639; pfam11121 691437005432 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 691437005433 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 691437005434 putative substrate translocation pore; other site 691437005435 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 691437005436 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 691437005437 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 691437005438 Helix-turn-helix domains; Region: HTH; cl00088 691437005439 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 691437005440 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl15772 691437005441 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl15772 691437005442 enoyl-CoA hydratase; Provisional; Region: PRK07657 691437005443 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 691437005444 substrate binding site [chemical binding]; other site 691437005445 oxyanion hole (OAH) forming residues; other site 691437005446 trimer interface [polypeptide binding]; other site 691437005447 3-hydroxy-3-methylglutaryl-CoA lyase, catalytic TIM barrel domain; Region: DRE_TIM_HMGL; cd07938 691437005448 active site 691437005449 catalytic residues [active] 691437005450 metal binding site [ion binding]; metal-binding site 691437005451 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 691437005452 carboxyltransferase (CT) interaction site; other site 691437005453 biotinylation site [posttranslational modification]; other site 691437005454 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK06111 691437005455 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 691437005456 ATP-grasp domain; Region: ATP-grasp_4; cl03087 691437005457 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; cl08365 691437005458 AMP-binding domain protein; Validated; Region: PRK08315 691437005459 AMP-binding enzyme; Region: AMP-binding; cl15778 691437005460 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 691437005461 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 691437005462 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 691437005463 active site 691437005464 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 691437005465 Helix-turn-helix domains; Region: HTH; cl00088 691437005466 YsiA-like protein, C-terminal region; Region: TetR_C_4; pfam08359 691437005467 Predicted acetyltransferase [General function prediction only]; Region: COG3393 691437005468 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 691437005469 threonine dehydratase; Provisional; Region: PRK08198 691437005470 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 691437005471 tetramer interface [polypeptide binding]; other site 691437005472 pyridoxal 5'-phosphate binding site [chemical binding]; other site 691437005473 catalytic residue [active] 691437005474 C-terminal ACT domain of biodegradative (catabolic) threonine dehydratase II (ThrD-II) and other related ACT domains; Region: ACT_ThrD-II-like; cd04886 691437005475 Predicted metal-dependent hydrolases related to alanyl-tRNA synthetase HxxxH domain [General function prediction only]; Region: COG2872 691437005476 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; cl08469 691437005477 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 691437005478 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 691437005479 putative active site [active] 691437005480 heme pocket [chemical binding]; other site 691437005481 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 691437005482 dimer interface [polypeptide binding]; other site 691437005483 phosphorylation site [posttranslational modification] 691437005484 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 691437005485 ATP binding site [chemical binding]; other site 691437005486 Mg2+ binding site [ion binding]; other site 691437005487 G-X-G motif; other site 691437005488 multidrug efflux protein; Reviewed; Region: PRK01766 691437005489 MatE; Region: MatE; cl10513 691437005490 MatE; Region: MatE; cl10513 691437005491 Family of unknown function (DUF1028); Region: DUF1028; pfam06267 691437005492 Putative peptidoglycan binding domain; Region: PG_binding_1; cl15437 691437005493 Predicted permeases [General function prediction only]; Region: RarD; COG2962 691437005494 EamA-like transporter family; Region: EamA; cl01037 691437005495 CorA-like Mg2+ transporter protein; Region: CorA; pfam01544 691437005496 Plant ATP synthase F0; Region: YMF19; cl07975 691437005497 magnesium/nickel/cobalt transporter CorA; Provisional; Region: PRK11085; cl00459 691437005498 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 691437005499 Cation efflux family; Region: Cation_efflux; cl00316 691437005500 Methyltransferase domain; Region: Methyltransf_31; pfam13847 691437005501 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 691437005502 S-adenosylmethionine binding site [chemical binding]; other site 691437005503 D-ala-D-ala dipeptidase; Region: Peptidase_M15; cl00813 691437005504 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 691437005505 Uridine phosphorylase [Nucleotide transport and metabolism]; Region: Udp; COG2820 691437005506 YodL-like; Region: YodL; pfam14191 691437005507 Protein of unknown function (DUF2515); Region: DUF2515; pfam10720 691437005508 YozD-like protein; Region: YozD; pfam14162 691437005509 Protein of unknown function (DUF1250); Region: DUF1250; cl11485 691437005510 biotin synthase; Validated; Region: PRK06256 691437005511 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 691437005512 FeS/SAM binding site; other site 691437005513 Biotin and Thiamin Synthesis associated domain; Region: BATS; cl06149 691437005514 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 691437005515 magnesium/nickel/cobalt transporter CorA; Provisional; Region: PRK11085; cl00459 691437005516 Iron-sulphur cluster biosynthesis; Region: Fe-S_biosyn; cl00400 691437005517 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 691437005518 CoenzymeA binding site [chemical binding]; other site 691437005519 subunit interaction site [polypeptide binding]; other site 691437005520 PHB binding site; other site 691437005521 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 691437005522 active site 691437005523 small acid-soluble spore protein Tlp; Provisional; Region: PRK03830; cl07951 691437005524 Small acid-soluble spore protein N family; Region: SspN; cl11659 691437005525 periplasmic protein thiol:disulfide oxidoreductases, DsbE subfamily; Region: dsbE; TIGR00385 691437005526 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 691437005527 catalytic residues [active] 691437005528 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 691437005529 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 691437005530 active site residue [active] 691437005531 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 691437005532 active site residue [active] 691437005533 Protein of unknown function (DUF2533); Region: DUF2533; pfam10752 691437005534 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 691437005535 Dynamin-like protein including dynamins, mitofusins, and guanylate-binding proteins; Region: DLP_2; cd09912 691437005536 Dynamin family; Region: Dynamin_N; pfam00350 691437005537 G1 box; other site 691437005538 GTP/Mg2+ binding site [chemical binding]; other site 691437005539 G2 box; other site 691437005540 Switch I region; other site 691437005541 G3 box; other site 691437005542 Switch II region; other site 691437005543 G4 box; other site 691437005544 G5 box; other site 691437005545 Dynamin family; Region: Dynamin_N; pfam00350 691437005546 Dynamin-like protein including dynamins, mitofusins, and guanylate-binding proteins; Region: DLP_2; cd09912 691437005547 G3 box; other site 691437005548 Switch II region; other site 691437005549 GTP/Mg2+ binding site [chemical binding]; other site 691437005550 G4 box; other site 691437005551 G5 box; other site 691437005552 Phospholipid methyltransferase; Region: PEMT; cl00763 691437005553 Predicted naringenin-chalcone synthase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: BcsA; COG3424 691437005554 Chalcone and stilbene synthases; plant-specific polyketide synthases (PKS) and related enzymes, also called type III PKSs. PKS generate an array of different products, dependent on the nature of the starter molecule. They share a common chemical strategy; Region: CHS_like; cd00831 691437005555 malonyl-CoA binding site [chemical binding]; other site 691437005556 dimer interface [polypeptide binding]; other site 691437005557 active site 691437005558 product binding site; other site 691437005559 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 691437005560 Protein of unknown function (DUF1664); Region: DUF1664; pfam07889 691437005561 pyrimidine utilization transport protein G; Region: RutG; TIGR03616 691437005562 xanthine permease; Region: pbuX; TIGR03173 691437005563 Adenine/guanine phosphoribosyltransferases and related PRPP-binding proteins [Nucleotide transport and metabolism]; Region: Apt; COG0503 691437005564 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 691437005565 active site 691437005566 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; cl11412 691437005567 Heme-copper oxidase subunit I. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which catalyze the reduction of O2 and simultaneously pump protons across the membrane. The superfamily is...; Region: Heme_Cu_Oxidase_I; cl00275 691437005568 D-pathway; other site 691437005569 Low-spin heme binding site [chemical binding]; other site 691437005570 Putative water exit pathway; other site 691437005571 Binuclear center (active site) [active] 691437005572 K-pathway; other site 691437005573 Putative proton exit pathway; other site 691437005574 Zn-dependent carboxypeptidase [Amino acid transport and metabolism]; Region: COG2317 691437005575 Peptidase family M32 includes thermostable carboxypeptidases TaqCP and PfuCP; Region: M32_Taq; cd06460 691437005576 active site 691437005577 Zn binding site [ion binding]; other site 691437005578 Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199 691437005579 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 691437005580 Predicted N6-adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0116 691437005581 THUMP domain; Region: THUMP; cl12076 691437005582 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 691437005583 cell division protein GpsB; Provisional; Region: PRK14127 691437005584 DivIVA domain; Region: DivI1A_domain; TIGR03544 691437005585 Inner spore coat protein D; Region: Spore-coat_CotD; pfam11122 691437005586 DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012 691437005587 helicase/secretion neighborhood putative DEAH-box helicase; Region: DECH_helic; TIGR03817 691437005588 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 691437005589 ATP binding site [chemical binding]; other site 691437005590 putative Mg++ binding site [ion binding]; other site 691437005591 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 691437005592 nucleotide binding region [chemical binding]; other site 691437005593 ATP-binding site [chemical binding]; other site 691437005594 Domain of unknown function (DUF1998); Region: DUF1998; pfam09369 691437005595 Transcriptional regulator [Transcription]; Region: IclR; COG1414 691437005596 Helix-turn-helix domains; Region: HTH; cl00088 691437005597 Bacterial transcriptional regulator; Region: IclR; pfam01614 691437005598 Domain of unknown function (DUF2437); Region: DUF2437; pfam10370 691437005599 4-hydroxyphenylacetate degradation bifunctional isomerase/decarboxylase, C-terminal subunit; Region: HpaG-C-term; TIGR02303 691437005600 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 691437005601 Malic enzyme [Energy production and conversion]; Region: SfcA; COG0281 691437005602 Malic enzyme, N-terminal domain; Region: malic; pfam00390 691437005603 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 691437005604 putative NAD(P) binding site [chemical binding]; other site 691437005605 Malate synthase G (MSG), monomeric enzyme present in some bacteria. In general, malate synthase catalyzes the Claisen condensation of glyoxylate and acetyl-CoA to malyl-CoA , which hydrolyzes to malate and CoA. This reaction is part of the glyoxylate...; Region: malate_synt_G; cd00728 691437005606 active site 691437005607 FAD binding domain; Region: FAD_binding_4; pfam01565 691437005608 glycolate oxidase, subunit GlcD; Region: glcD; TIGR00387 691437005609 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 691437005610 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 691437005611 Cysteine-rich domain; Region: CCG; pfam02754 691437005612 Cysteine-rich domain; Region: CCG; pfam02754 691437005613 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 691437005614 FAD binding domain; Region: FAD_binding_4; pfam01565 691437005615 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 691437005616 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 691437005617 hydroxypyruvate isomerase; Region: OH-pyruv-isom; TIGR03234 691437005618 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 691437005619 Helix-turn-helix domains; Region: HTH; cl00088 691437005620 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 691437005621 This family of ATP-binding proteins belongs to a multisubunit transporter involved in drug resistance (BcrA and DrrA), nodulation, lipid transport, and lantibiotic immunity. In bacteria and archaea, these transporters usually include an ATP-binding...; Region: ABC_DR_subfamily_A; cd03230 691437005622 Walker A/P-loop; other site 691437005623 ATP binding site [chemical binding]; other site 691437005624 Q-loop/lid; other site 691437005625 ABC transporter signature motif; other site 691437005626 Walker B; other site 691437005627 D-loop; other site 691437005628 H-loop/switch region; other site 691437005629 Bacterial BAX inhibitor (BI)-1/YccA-like proteins; Region: BI-1-like_bacterial; cd10432 691437005630 Putative ammonia monooxygenase [General function prediction only]; Region: AbrB; COG3180 691437005631 membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082 691437005632 membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082 691437005633 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 691437005634 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 691437005635 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 691437005636 dimer interface [polypeptide binding]; other site 691437005637 pyridoxal 5'-phosphate binding site [chemical binding]; other site 691437005638 catalytic residue [active] 691437005639 Histidine kinase N terminal; Region: HisK_N; pfam09385 691437005640 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 691437005641 dimer interface [polypeptide binding]; other site 691437005642 phosphorylation site [posttranslational modification] 691437005643 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 691437005644 ATP binding site [chemical binding]; other site 691437005645 Mg2+ binding site [ion binding]; other site 691437005646 G-X-G motif; other site 691437005647 Cytochrome c peroxidase [Inorganic ion transport and metabolism]; Region: MauG; COG1858 691437005648 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cl00264 691437005649 Coat F domain; Region: Coat_F; cl15836 691437005650 Peptidase S8 family domain in Thermitase-like proteins; Region: Peptidases_S8_Thermitase_like; cd07484 691437005651 active site 691437005652 catalytic triad [active] 691437005653 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 691437005654 mttA/Hcf106 family; Region: MttA_Hcf106; cl00788 691437005655 Small acid-soluble spore protein H family; Region: SspH; cl06949 691437005656 OpgC protein; Region: OpgC_C; cl00792 691437005657 OpgC protein; Region: OpgC_C; cl00792 691437005658 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 691437005659 thiamine phosphate binding site [chemical binding]; other site 691437005660 active site 691437005661 pyrophosphate binding site [ion binding]; other site 691437005662 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 691437005663 dimer interface [polypeptide binding]; other site 691437005664 substrate binding site [chemical binding]; other site 691437005665 ATP binding site [chemical binding]; other site 691437005666 4-methyl-5-beta-hydroxyethylthiazole (Thz) kinase catalyzes the phosphorylation of the hydroxylgroup of Thz. A reaction that allows cells to recycle Thz into the thiamine biosynthesis pathway, as an alternative to its synthesis from cysteine, tyrosine...; Region: THZ_kinase; cd01170 691437005667 substrate binding site [chemical binding]; other site 691437005668 multimerization interface [polypeptide binding]; other site 691437005669 ATP binding site [chemical binding]; other site 691437005670 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 691437005671 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 691437005672 Ligand binding site; other site 691437005673 Putative Catalytic site; other site 691437005674 DXD motif; other site 691437005675 Predicted membrane protein (DUF2079); Region: DUF2079; pfam09852 691437005676 Phosphotriesterase (PTE) catalyzes the hydrolysis of organophosphate nerve agents, including the chemical warfare agents VX, soman, and sarin as well as the insecticide paraoxon. PTE exists as a homodimer with one active site per monomer. The active site...; Region: PTE; cd00530 691437005677 active site 691437005678 substrate binding pocket [chemical binding]; other site 691437005679 homodimer interaction site [polypeptide binding]; other site 691437005680 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK08314 691437005681 AMP-binding enzyme; Region: AMP-binding; cl15778 691437005682 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 691437005683 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011 691437005684 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 691437005685 motif II; other site 691437005686 Excalibur calcium-binding domain; Region: Excalibur; cl05460 691437005687 Protein of unknown function (DUF523); Region: DUF523; cl00733 691437005688 Protein of unknown function (DUF1722); Region: DUF1722; cl01284 691437005689 LamB/YcsF family; Region: LamB_YcsF; cl00664 691437005690 Allophanate hydrolase subunit 2; Region: AHS2; cl00865 691437005691 Allophanate hydrolase subunit 1; Region: AHS1; pfam02682 691437005692 Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; cl00896 691437005693 Transcriptional regulator [Transcription]; Region: IclR; COG1414 691437005694 Helix-turn-helix domains; Region: HTH; cl00088 691437005695 Bacterial transcriptional regulator; Region: IclR; pfam01614 691437005696 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 691437005697 Coenzyme A binding pocket [chemical binding]; other site 691437005698 putative carbohydrate kinase; Provisional; Region: PRK10565 691437005699 YjeF-related protein N-terminus; Region: YjeF_N; cl00318 691437005700 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 691437005701 putative substrate binding site [chemical binding]; other site 691437005702 putative ATP binding site [chemical binding]; other site 691437005703 ClpX C4-type zinc finger; Region: zf-C4_ClpX; cl05964 691437005704 Protein of unknown function, DUF393; Region: DUF393; cl01136 691437005705 Uncharacterized ACR, COG2135; Region: DUF159; cl03646 691437005706 Response regulator receiver domain; Region: Response_reg; pfam00072 691437005707 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 691437005708 active site 691437005709 phosphorylation site [posttranslational modification] 691437005710 intermolecular recognition site; other site 691437005711 dimerization interface [polypeptide binding]; other site 691437005712 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 691437005713 metal binding site [ion binding]; metal-binding site 691437005714 active site 691437005715 I-site; other site 691437005716 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 691437005717 active site 691437005718 phosphorylation site [posttranslational modification] 691437005719 intermolecular recognition site; other site 691437005720 dimerization interface [polypeptide binding]; other site 691437005721 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 691437005722 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 691437005723 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 691437005724 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 691437005725 active site 691437005726 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187 691437005727 AMP-binding enzyme; Region: AMP-binding; cl15778 691437005728 AMP-binding enzyme; Region: AMP-binding; cl15778 691437005729 Helix-Turn-Helix DNA binding domain of the regulatory protein GnyR; Region: HTH_GnyR; cd04776 691437005730 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 691437005731 DNA binding residues [nucleotide binding] 691437005732 putative dimer interface [polypeptide binding]; other site 691437005733 ABC-2 family transporter protein; Region: ABC2_membrane_6; cl01496 691437005734 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4587 691437005735 ABC-2 family transporter protein; Region: ABC2_membrane_6; cl01496 691437005736 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4586 691437005737 Similar in sequence to NatA, this is the ATPase component of a bacterial ABC-type Na+ transport system called NatAB, which catalyzes ATP-dependent electrogenic Na+ extrusion without mechanically coupled to proton or K+ uptake. NatB possess six putative...; Region: ABC_NatA_like; cd03267 691437005738 Walker A/P-loop; other site 691437005739 ATP binding site [chemical binding]; other site 691437005740 Q-loop/lid; other site 691437005741 ABC transporter signature motif; other site 691437005742 Walker B; other site 691437005743 D-loop; other site 691437005744 H-loop/switch region; other site 691437005745 bifunctional uroporphyrinogen-III synthetase/uroporphyrin-III C-methyltransferase; Reviewed; Region: PRK06975 691437005746 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 691437005747 LivF (TM1139) is part of the LIV-I bacterial ABC-type two-component transport system that imports neutral, branched-chain amino acids. The E. coli branched-chain amino acid transporter comprises a heterodimer of ABC transporters (LivF and LivG), a...; Region: ABC_TM1139_LivF_branched; cd03224 691437005748 Walker A/P-loop; other site 691437005749 ATP binding site [chemical binding]; other site 691437005750 Q-loop/lid; other site 691437005751 ABC transporter signature motif; other site 691437005752 Walker B; other site 691437005753 D-loop; other site 691437005754 H-loop/switch region; other site 691437005755 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 691437005756 TM-ABC transporter signature motif; other site 691437005757 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 691437005758 TM-ABC transporter signature motif; other site 691437005759 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 691437005760 Type I periplasmic binding component of active transport systems that are predicted be involved in anaerobic biodegradation of alkylbenzenes such as toluene and ethylbenzene; Region: PBP1_alkylbenzenes_like; cd06360 691437005761 putative ligand binding site [chemical binding]; other site 691437005762 Gentisate 1,2-dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3435 691437005763 Cupin domain; Region: Cupin_2; cl09118 691437005764 Cupin domain; Region: Cupin_2; cl09118 691437005765 DinB superfamily; Region: DinB_2; pfam12867 691437005766 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 691437005767 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 691437005768 active site 691437005769 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 691437005770 salicylate hydroxylase; Provisional; Region: PRK08163 691437005771 Coenzyme F390 synthetase [Coenzyme metabolism]; Region: PaaK; COG1541 691437005772 AMP-binding enzyme; Region: AMP-binding; cl15778 691437005773 Transcriptional regulator [Transcription]; Region: IclR; COG1414 691437005774 Helix-turn-helix domains; Region: HTH; cl00088 691437005775 Bacterial transcriptional regulator; Region: IclR; pfam01614 691437005776 Transcriptional regulator [Transcription]; Region: IclR; COG1414 691437005777 Helix-turn-helix domains; Region: HTH; cl00088 691437005778 Bacterial transcriptional regulator; Region: IclR; pfam01614 691437005779 NADP+-dependent p-hydroxybenzaldehyde dehydrogenase-like; Region: ALDH_HBenzADH; cd07151 691437005780 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 691437005781 NAD(P) binding site [chemical binding]; other site 691437005782 catalytic residues [active] 691437005783 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 691437005784 LivF (TM1139) is part of the LIV-I bacterial ABC-type two-component transport system that imports neutral, branched-chain amino acids. The E. coli branched-chain amino acid transporter comprises a heterodimer of ABC transporters (LivF and LivG), a...; Region: ABC_TM1139_LivF_branched; cd03224 691437005785 Walker A/P-loop; other site 691437005786 ATP binding site [chemical binding]; other site 691437005787 Q-loop/lid; other site 691437005788 ABC transporter signature motif; other site 691437005789 Walker B; other site 691437005790 D-loop; other site 691437005791 H-loop/switch region; other site 691437005792 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 691437005793 The Mj1267/LivG ABC transporter subfamily is involved in the transport of the hydrophobic amino acids leucine, isoleucine and valine. MJ1267 is a branched-chain amino acid transporter with 29% similarity to both the LivF and LivG components of the E; Region: ABC_Mj1267_LivG_branched; cd03219 691437005794 Walker A/P-loop; other site 691437005795 ATP binding site [chemical binding]; other site 691437005796 Q-loop/lid; other site 691437005797 ABC transporter signature motif; other site 691437005798 Walker B; other site 691437005799 D-loop; other site 691437005800 H-loop/switch region; other site 691437005801 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 691437005802 TM-ABC transporter signature motif; other site 691437005803 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 691437005804 TM-ABC transporter signature motif; other site 691437005805 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 691437005806 Type I periplasmic binding proteins of active transport systems that are predicted to be involved in transport of aromatic compounds such as 2-nitrobenzoic acid and alkylbenzenes; Region: PBP1_aromatic_compounds_like; cd06332 691437005807 putative ligand binding site [chemical binding]; other site 691437005808 Subunit B of Class III Extradiol ring-cleavage dioxygenases; Region: Extradiol_Dioxygenase_3B_like; cl00599 691437005809 active site 691437005810 metal binding site [ion binding]; metal-binding site 691437005811 4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235 691437005812 active site 1 [active] 691437005813 dimer interface [polypeptide binding]; other site 691437005814 hexamer interface [polypeptide binding]; other site 691437005815 active site 2 [active] 691437005816 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 691437005817 4-hyroxy-2-oxovalerate/4-hydroxy-2-oxopentanoic acid aldolase,; Validated; Region: PRK08195 691437005818 4-hydroxy-2-oxovalerate aldolase, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_HOA; cd07943 691437005819 active site 691437005820 catalytic residues [active] 691437005821 metal binding site [ion binding]; metal-binding site 691437005822 DmpG-like communication domain; Region: DmpG_comm; pfam07836 691437005823 acetaldehyde dehydrogenase; Validated; Region: PRK08300 691437005824 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 691437005825 Prokaryotic acetaldehyde dehydrogenase, dimerisation; Region: AcetDehyd-dimer; pfam09290 691437005826 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 691437005827 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 691437005828 Human aldehyde dehydrogenase family 8 member A1-like; Region: ALDH_F8_HMSADH; cd07093 691437005829 NAD binding site [chemical binding]; other site 691437005830 catalytic residues [active] 691437005831 Transcriptional regulator [Transcription]; Region: IclR; COG1414 691437005832 Helix-turn-helix domains; Region: HTH; cl00088 691437005833 Bacterial transcriptional regulator; Region: IclR; pfam01614 691437005834 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 691437005835 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 691437005836 2-octaprenyl-3-methyl-6-methoxy-1,4-benzoquinol hydroxylase; Provisional; Region: PRK08849 691437005837 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 691437005838 putative substrate translocation pore; other site 691437005839 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 691437005840 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 691437005841 cyclohexanecarboxylate-CoA ligase; Reviewed; Region: PRK13295 691437005842 AMP-binding enzyme; Region: AMP-binding; cl15778 691437005843 AMP-binding enzyme; Region: AMP-binding; cl15778 691437005844 Gentisate 1,2-dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3435 691437005845 Cupin domain; Region: Cupin_2; cl09118 691437005846 Cupin domain; Region: Cupin_2; cl09118 691437005847 Transcriptional regulator [Transcription]; Region: IclR; COG1414 691437005848 Helix-turn-helix domains; Region: HTH; cl00088 691437005849 Bacterial transcriptional regulator; Region: IclR; pfam01614 691437005850 putative acyltransferase; Provisional; Region: PRK05790 691437005851 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 691437005852 dimer interface [polypeptide binding]; other site 691437005853 active site 691437005854 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187 691437005855 AMP-binding enzyme; Region: AMP-binding; cl15778 691437005856 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 691437005857 Protein of unknown function (DUF3237); Region: DUF3237; cl07905 691437005858 benzoate transport; Region: 2A0115; TIGR00895 691437005859 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 691437005860 putative substrate translocation pore; other site 691437005861 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 691437005862 3-hydroxybutyryl-CoA dehydratase; Validated; Region: PRK05809 691437005863 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 691437005864 substrate binding site [chemical binding]; other site 691437005865 oxyanion hole (OAH) forming residues; other site 691437005866 trimer interface [polypeptide binding]; other site 691437005867 3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK05808 691437005868 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 691437005869 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 691437005870 GAF domain; Region: GAF_2; pfam13185 691437005871 GAF domain; Region: GAF; cl15785 691437005872 GAF domain; Region: GAF_2; pfam13185 691437005873 GAF domain; Region: GAF; cl15785 691437005874 Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508 691437005875 Helix-turn-helix domains; Region: HTH; cl00088 691437005876 acetoacetyl-CoA synthetase; Provisional; Region: PRK03584 691437005877 Domain of unknown function (DUF3448); Region: DUF3448; pfam11930 691437005878 AMP-binding enzyme; Region: AMP-binding; cl15778 691437005879 FeoA domain; Region: FeoA; cl00838 691437005880 Ferrous iron transport protein B; Region: FeoB_N; pfam02421 691437005881 Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879 691437005882 G1 box; other site 691437005883 GTP/Mg2+ binding site [chemical binding]; other site 691437005884 Switch I region; other site 691437005885 G2 box; other site 691437005886 G3 box; other site 691437005887 Switch II region; other site 691437005888 G4 box; other site 691437005889 G5 box; other site 691437005890 Nucleoside recognition; Region: Gate; cl00486 691437005891 Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664 691437005892 Nucleoside recognition; Region: Gate; cl00486 691437005893 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 691437005894 catalytic core [active] 691437005895 LD-Carboxypeptidase, a serine protease, includes microcin C7 self immunity protein; Region: Peptidase_S66; cl00700 691437005896 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 691437005897 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 691437005898 Coenzyme A binding pocket [chemical binding]; other site 691437005899 PAS fold; Region: PAS_3; pfam08447 691437005900 Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain); Region: PAC; smart00086 691437005901 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 691437005902 metal binding site [ion binding]; metal-binding site 691437005903 active site 691437005904 I-site; other site 691437005905 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 691437005906 siderophore-iron reductase FhuF; Region: Fe_III_red_FhuF; TIGR03951 691437005907 Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276 691437005908 FhuF 2Fe-2S C-terminal domain; Region: FhuF_C; pfam11575 691437005909 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 691437005910 ABC transporters, involved in the uptake of siderophores, heme, and vitamin B12, are widely conserved in bacteria and archaea. Only very few species lack representatives of the siderophore family transporters. The E. coli BtuCD protein is an ABC...; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 691437005911 Walker A/P-loop; other site 691437005912 ATP binding site [chemical binding]; other site 691437005913 Q-loop/lid; other site 691437005914 ABC transporter signature motif; other site 691437005915 Walker B; other site 691437005916 D-loop; other site 691437005917 H-loop/switch region; other site 691437005918 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 691437005919 ABC-ATPase subunit interface; other site 691437005920 dimer interface [polypeptide binding]; other site 691437005921 putative PBP binding regions; other site 691437005922 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 691437005923 ABC-ATPase subunit interface; other site 691437005924 dimer interface [polypeptide binding]; other site 691437005925 putative PBP binding regions; other site 691437005926 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 691437005927 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 691437005928 siderophore binding site; other site 691437005929 Protein of unknown function with PCYCGC motif; Region: PCYCGC; pfam13798 691437005930 hypothetical protein; Provisional; Region: PRK07740 691437005931 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 691437005932 active site 691437005933 catalytic site [active] 691437005934 substrate binding site [chemical binding]; other site 691437005935 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 691437005936 metal binding triad; other site 691437005937 Putative nucleotidyltransferase substrate binding domain; Region: DUF294_C; pfam10335 691437005938 Ammonium Transporter Family; Region: Ammonium_transp; cl03012 691437005939 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 691437005940 Protein of unknown function (DUF4025); Region: DUF4025; pfam13217 691437005941 Protein of unknown function (DUF2512); Region: DUF2512; pfam10710 691437005942 Toxic anion resistance protein (TelA); Region: TelA; pfam05816 691437005943 5-bromo-4-chloroindolyl phosphate hydrolysis protein; Region: Halogen_Hydrol; cl02059 691437005944 Protein of unknown function (DUF3325); Region: DUF3325; pfam11804 691437005945 Predicted membrane protein [Function unknown]; Region: COG4640 691437005946 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 691437005947 Major Facilitator Superfamily; Region: MFS_1; pfam07690 691437005948 putative substrate translocation pore; other site 691437005949 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 691437005950 alpha-mannosidase; Provisional; Region: PRK09819 691437005951 hypothetical protein; Provisional; Region: PRK02947 691437005952 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 691437005953 putative active site [active] 691437005954 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 691437005955 Malic enzyme, N-terminal domain; Region: malic; pfam00390 691437005956 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 691437005957 putative NAD(P) binding site [chemical binding]; other site 691437005958 intracellular protease, PfpI family; Region: PfpI; TIGR01382 691437005959 Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_1; cd03169 691437005960 conserved cys residue [active] 691437005961 NAD-dependent deacetylase; Provisional; Region: PRK00481 691437005962 SIR2_Af2: Archaeal and prokaryotic group which includes Archaeoglobus fulgidus Sir2-Af2, Sulfolobus solfataricus ssSir2, and several bacterial homologs; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which...; Region: SIR2_Af2; cd01413 691437005963 NAD+ binding site [chemical binding]; other site 691437005964 substrate binding site [chemical binding]; other site 691437005965 Zn binding site [ion binding]; other site 691437005966 Phosphotransferase enzyme family; Region: APH; pfam01636 691437005967 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: APH_ChoK_like; cd05120 691437005968 active site 691437005969 ATP binding site [chemical binding]; other site 691437005970 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 691437005971 substrate binding site [chemical binding]; other site 691437005972 Predicted membrane protein (DUF2157); Region: DUF2157; cl10480 691437005973 GDYXXLXY protein; Region: GDYXXLXY; cl02066 691437005974 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 691437005975 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 691437005976 active site 691437005977 glutamate synthase subunit beta; Reviewed; Region: gltD; PRK12810 691437005978 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 691437005979 glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750 691437005980 Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713 691437005981 active site 691437005982 dimer interface [polypeptide binding]; other site 691437005983 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 691437005984 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 691437005985 active site 691437005986 FMN binding site [chemical binding]; other site 691437005987 substrate binding site [chemical binding]; other site 691437005988 3Fe-4S cluster binding site [ion binding]; other site 691437005989 gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982 691437005990 domain interface; other site 691437005991 Transcriptional regulator [Transcription]; Region: LysR; COG0583 691437005992 Helix-turn-helix domains; Region: HTH; cl00088 691437005993 The substrate binding domain of LysR-type transcriptional regulator GltC, which activates gltA expression of glutamate synthase operon, contains type 2 periplasmic binding fold; Region: PBP2_GltC_like; cd08434 691437005994 putative dimerization interface [polypeptide binding]; other site 691437005995 Yhfp putative quinone oxidoreductases; Region: MDR_yhfp_like; cd08289 691437005996 putative quinone oxidoreductase, YhdH/YhfP family; Region: oxido_YhdH; TIGR02823 691437005997 putative NADP binding site [chemical binding]; other site 691437005998 putative dimer interface [polypeptide binding]; other site 691437005999 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 691437006000 putative active site [active] 691437006001 aminotransferase; Validated; Region: PRK07678 691437006002 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 691437006003 inhibitor-cofactor binding pocket; inhibition site 691437006004 pyridoxal 5'-phosphate binding site [chemical binding]; other site 691437006005 catalytic residue [active] 691437006006 Purine catabolism regulatory protein-like family; Region: PucR; pfam07905 691437006007 Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508 691437006008 Helix-turn-helix domains; Region: HTH; cl00088 691437006009 gamma-aminobutyrate permease; Region: GABAperm; TIGR01773 691437006010 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 691437006011 RecB family nuclease, putative, TM0106 family; Region: TIGR03491 691437006012 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 691437006013 Family description; Region: UvrD_C_2; cl15862 691437006014 ABC-type enterochelin transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: CeuA; COG4607 691437006015 Siderophore binding protein FatB. These proteins have been shown to function as ABC-type initial receptors in the siderophore-mediated iron uptake in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins...; Region: FatB; cd01140 691437006016 putative ligand binding residues [chemical binding]; other site 691437006017 ABC-type enterochelin transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CeuD; COG4604 691437006018 ABC transporters, involved in the uptake of siderophores, heme, and vitamin B12, are widely conserved in bacteria and archaea. Only very few species lack representatives of the siderophore family transporters. The E. coli BtuCD protein is an ABC...; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 691437006019 Walker A/P-loop; other site 691437006020 ATP binding site [chemical binding]; other site 691437006021 Q-loop/lid; other site 691437006022 ABC transporter signature motif; other site 691437006023 Walker B; other site 691437006024 D-loop; other site 691437006025 H-loop/switch region; other site 691437006026 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 691437006027 ABC-ATPase subunit interface; other site 691437006028 dimer interface [polypeptide binding]; other site 691437006029 putative PBP binding regions; other site 691437006030 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 691437006031 ABC-ATPase subunit interface; other site 691437006032 dimer interface [polypeptide binding]; other site 691437006033 putative PBP binding regions; other site 691437006034 Bacillus subtilis NADP+-dependent alpha-ketoglutaric semialdehyde dehydrogenase ycbD-like; Region: ALDH_KGSADH-YcbD; cd07097 691437006035 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 691437006036 NAD(P) binding site [chemical binding]; other site 691437006037 catalytic residues [active] 691437006038 sulfite reductase subunit beta; Provisional; Region: PRK13504 691437006039 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 691437006040 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 691437006041 sulfite reductase [NADPH] flavoprotein, alpha-component; Region: cysJ; TIGR01931 691437006042 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 691437006043 Cytochrome p450- like alpha subunits of E. coli sulfite reductase (SiR) multimerize with beta subunits to catalyze the NADPH dependent reduction of sulfite to sulfide. Beta subunits have an Fe4S4 cluster and a siroheme, while the alpha subunits (cysJ...; Region: SiR; cd06199 691437006044 FAD binding pocket [chemical binding]; other site 691437006045 FAD binding motif [chemical binding]; other site 691437006046 catalytic residues [active] 691437006047 NAD binding pocket [chemical binding]; other site 691437006048 phosphate binding motif [ion binding]; other site 691437006049 beta-alpha-beta structure motif; other site 691437006050 Helix-turn-helix domains; Region: HTH; cl00088 691437006051 putative DNA-binding transcriptional regulator; Provisional; Region: PRK10837 691437006052 C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420 691437006053 putative dimerization interface [polypeptide binding]; other site 691437006054 Cation efflux family; Region: Cation_efflux; cl00316 691437006055 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 691437006056 dimerization interface [polypeptide binding]; other site 691437006057 putative DNA binding site [nucleotide binding]; other site 691437006058 putative Zn2+ binding site [ion binding]; other site 691437006059 Putative heavy-metal-binding; Region: YbjQ_1; cl00426 691437006060 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859 691437006061 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 691437006062 FAD dependent oxidoreductase; Region: DAO; pfam01266 691437006063 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 691437006064 hypothetical protein; Provisional; Region: PRK03057 691437006065 UPF0302 domain; Region: UPF0302; pfam08864 691437006066 IDEAL domain; Region: IDEAL; cl07452 691437006067 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 691437006068 Predicted dehydrogenase [General function prediction only]; Region: COG0579 691437006069 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 691437006070 Amidase; Region: Amidase; cl11426 691437006071 Acetamidase/Formamidase family; Region: FmdA_AmdA; cl01023 691437006072 Uncharacterized conserved protein [Function unknown]; Region: COG4127 691437006073 EVE domain; Region: EVE; cl00728 691437006074 Restriction endonuclease; Region: Mrr_cat; cl00516 691437006075 Restriction endonuclease [Defense mechanisms]; Region: COG3587 691437006076 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 691437006077 Adenine specific DNA methylase Mod [DNA replication, recombination, and repair]; Region: COG2189 691437006078 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 691437006079 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 691437006080 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 691437006081 Domain of unknown function (DUF4391); Region: DUF4391; pfam14335 691437006082 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 691437006083 non-specific DNA binding site [nucleotide binding]; other site 691437006084 salt bridge; other site 691437006085 sequence-specific DNA binding site [nucleotide binding]; other site 691437006086 Domain of unknown function (DUF2357); Region: DUF2357; pfam09823 691437006087 Protein of unknown function (DUF524); Region: DUF524; pfam04411 691437006088 Domain of unknown function (DUF3578); Region: DUF3578; pfam12102 691437006089 GTPase subunit of restriction endonuclease [Defense mechanisms]; Region: McrB; COG1401 691437006090 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 691437006091 The Class III extradiol dioxygenase, 4,5-DOPA Dioxygenase, catalyzes the incorporation of both atoms of molecular oxygen into 4,5-dihydroxy-phenylalanine; Region: 45_DOPA_Dioxygenase; cd07363 691437006092 putative active site [active] 691437006093 metal binding site [ion binding]; metal-binding site 691437006094 Predicted nucleic acid-binding protein, contains PIN domain [General function prediction only]; Region: COG2405 691437006095 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 691437006096 non-specific DNA binding site [nucleotide binding]; other site 691437006097 salt bridge; other site 691437006098 sequence-specific DNA binding site [nucleotide binding]; other site 691437006099 Domain of unknown function (DUF955); Region: DUF955; cl01076 691437006100 HEAT repeats; Region: HEAT_2; pfam13646 691437006101 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 691437006102 Indigoidine synthase A like protein; Region: Indigoidine_A; cl00983 691437006103 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 691437006104 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 691437006105 Probable transposase; Region: OrfB_IS605; pfam01385 691437006106 Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282 691437006107 putative inner membrane protein; Provisional; Region: PRK11099 691437006108 Sulphur transport; Region: Sulf_transp; cl01018 691437006109 putative inner membrane protein; Provisional; Region: PRK11099 691437006110 Sulphur transport; Region: Sulf_transp; cl01018 691437006111 Large-conductance mechanosensitive channel, MscL; Region: MscL; cl00860 691437006112 large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567 691437006113 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3314 691437006114 Nucleoside recognition; Region: Gate; cl00486 691437006115 imidazolonepropionase; Validated; Region: PRK09356 691437006116 Imidazolonepropionase/imidazolone-5-propionate hydrolase (Imidazolone-5PH) catalyzes the third step in the histidine degradation pathway, the hydrolysis of (S)-3-(5-oxo-4,5-dihydro-3H-imidazol-4-yl)propanoate to N-formimidoyl-L-glutamate. In bacteria; Region: Imidazolone-5PH; cd01296 691437006117 active site 691437006118 urocanate hydratase; Provisional; Region: PRK05414 691437006119 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 691437006120 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 691437006121 Arginase family; Region: Arginase; cl00306 691437006122 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 691437006123 CoenzymeA binding site [chemical binding]; other site 691437006124 subunit interaction site [polypeptide binding]; other site 691437006125 PHB binding site; other site 691437006126 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 691437006127 CoenzymeA binding site [chemical binding]; other site 691437006128 subunit interaction site [polypeptide binding]; other site 691437006129 PHB binding site; other site 691437006130 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 691437006131 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 691437006132 active site 691437006133 metal binding site [ion binding]; metal-binding site 691437006134 The substrate binding component of an ABC-type lactococcal OppA-like transport system contains; Region: PBP2_Lactococcal_OppA_like; cd08510 691437006135 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 691437006136 peptide binding site [polypeptide binding]; other site 691437006137 antimicrobial peptide ABC transporter permease SapC; Provisional; Region: PRK15111 691437006138 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 691437006139 dimer interface [polypeptide binding]; other site 691437006140 conserved gate region; other site 691437006141 putative PBP binding loops; other site 691437006142 ABC-ATPase subunit interface; other site 691437006143 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 691437006144 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 691437006145 dimer interface [polypeptide binding]; other site 691437006146 conserved gate region; other site 691437006147 putative PBP binding loops; other site 691437006148 ABC-ATPase subunit interface; other site 691437006149 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 691437006150 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 691437006151 Walker A/P-loop; other site 691437006152 ATP binding site [chemical binding]; other site 691437006153 Q-loop/lid; other site 691437006154 ABC transporter signature motif; other site 691437006155 Walker B; other site 691437006156 D-loop; other site 691437006157 H-loop/switch region; other site 691437006158 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 691437006159 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 691437006160 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 691437006161 Walker A/P-loop; other site 691437006162 ATP binding site [chemical binding]; other site 691437006163 Q-loop/lid; other site 691437006164 ABC transporter signature motif; other site 691437006165 Walker B; other site 691437006166 D-loop; other site 691437006167 H-loop/switch region; other site 691437006168 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 691437006169 glycerol kinase; Provisional; Region: glpK; PRK00047 691437006170 Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786 691437006171 N- and C-terminal domain interface [polypeptide binding]; other site 691437006172 active site 691437006173 MgATP binding site [chemical binding]; other site 691437006174 catalytic site [active] 691437006175 metal binding site [ion binding]; metal-binding site 691437006176 glycerol binding site [chemical binding]; other site 691437006177 homotetramer interface [polypeptide binding]; other site 691437006178 homodimer interface [polypeptide binding]; other site 691437006179 FBP binding site [chemical binding]; other site 691437006180 protein IIAGlc interface [polypeptide binding]; other site 691437006181 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333 691437006182 amphipathic channel; other site 691437006183 Asn-Pro-Ala signature motifs; other site 691437006184 Sporulation control protein [General function prediction only]; Region: Spo0M; COG4326 691437006185 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box protein; Region: CSP_CDS; cd04458 691437006186 DNA-binding site [nucleotide binding]; DNA binding site 691437006187 RNA-binding motif; other site 691437006188 Protein of unknown function (DUF2564); Region: DUF2564; pfam10819 691437006189 Protein of unknown function (DUF2602); Region: DUF2602; pfam10782 691437006190 hypothetical protein; Validated; Region: PRK07708 691437006191 RNAse HI family that includes Archaeal RNase HI; Region: RNase_HI_archaeal_like; cd09279 691437006192 RNA/DNA hybrid binding site [nucleotide binding]; other site 691437006193 active site 691437006194 EamA-like transporter family; Region: EamA; cl01037 691437006195 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 691437006196 EamA-like transporter family; Region: EamA; cl01037 691437006197 Divergent PAP2 family; Region: DUF212; cl00855 691437006198 small, acid-soluble spore protein L; Region: SASP_sspL; TIGR03093 691437006199 aconitate hydratase; Validated; Region: PRK09277 691437006200 Aconitase A catalytic domain; Region: AcnA_IRP; cd01586 691437006201 substrate binding site [chemical binding]; other site 691437006202 ligand binding site [chemical binding]; other site 691437006203 Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580 691437006204 substrate binding site [chemical binding]; other site 691437006205 Small acid-soluble spore protein O family; Region: SspO; cl07943 691437006206 Small acid-soluble spore protein P family; Region: SspP; cl12105 691437006207 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 691437006208 methionine cluster; other site 691437006209 active site 691437006210 phosphorylation site [posttranslational modification] 691437006211 metal binding site [ion binding]; metal-binding site 691437006212 YdjC-like protein; Region: YdjC; cl01344 691437006213 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; cl00557 691437006214 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 691437006215 active site 691437006216 P-loop; other site 691437006217 phosphorylation site [posttranslational modification] 691437006218 Helix-turn-helix domains; Region: HTH; cl00088 691437006219 Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain [Transcription / Signal transduction mechanisms]; Region: PspF; COG1221 691437006220 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 691437006221 Walker A motif; other site 691437006222 ATP binding site [chemical binding]; other site 691437006223 Walker B motif; other site 691437006224 arginine finger; other site 691437006225 Transcriptional antiterminator [Transcription]; Region: COG3933 691437006226 PRD domain; Region: PRD; cl15445 691437006227 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 691437006228 active pocket/dimerization site; other site 691437006229 active site 691437006230 phosphorylation site [posttranslational modification] 691437006231 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118 691437006232 putative peptidoglycan binding site; other site 691437006233 Cell Wall Hydrolase; Region: Hydrolase_2; pfam07486 691437006234 Protein of unknown function (DUF2621); Region: DUF2621; pfam11084 691437006235 Protein of unknown function (DUF1453); Region: DUF1453; cl02009 691437006236 Response regulator receiver domain; Region: Response_reg; pfam00072 691437006237 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 691437006238 active site 691437006239 phosphorylation site [posttranslational modification] 691437006240 intermolecular recognition site; other site 691437006241 dimerization interface [polypeptide binding]; other site 691437006242 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 691437006243 Spo0E like sporulation regulatory protein; Region: SpoOE-like; pfam09388 691437006244 putative multidrug transporter membrane\ATP-binding components; Provisional; Region: PRK10790 691437006245 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 691437006246 Glucan exporter ATP-binding protein. In A. tumefaciens cyclic beta-1, 2-glucan must be transported into the periplasmic space to exert its action as a virluence factor. This subfamily belongs to the MRP-like family and is involved in drug, peptide, and...; Region: ABCC_Glucan_exporter_like; cd03254 691437006247 Walker A/P-loop; other site 691437006248 ATP binding site [chemical binding]; other site 691437006249 Q-loop/lid; other site 691437006250 ABC transporter signature motif; other site 691437006251 Walker B; other site 691437006252 D-loop; other site 691437006253 H-loop/switch region; other site 691437006254 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 691437006255 putative multidrug transporter membrane\ATP-binding components; Provisional; Region: PRK10789 691437006256 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 691437006257 Walker A/P-loop; other site 691437006258 ATP binding site [chemical binding]; other site 691437006259 Q-loop/lid; other site 691437006260 ABC transporter signature motif; other site 691437006261 Walker B; other site 691437006262 D-loop; other site 691437006263 H-loop/switch region; other site 691437006264 Uncharacterized protein family (UPF0154); Region: UPF0154; cl01536 691437006265 Protein of unknown function (DUF2522); Region: DUF2522; pfam10747 691437006266 Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021 691437006267 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 691437006268 TPP-binding site [chemical binding]; other site 691437006269 dimer interface [polypeptide binding]; other site 691437006270 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 691437006271 PYR/PP interface [polypeptide binding]; other site 691437006272 dimer interface [polypeptide binding]; other site 691437006273 TPP binding site [chemical binding]; other site 691437006274 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 691437006275 Bacterial protein of unknown function (DUF896); Region: DUF896; cl01722 691437006276 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 691437006277 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 691437006278 catalytic residues [active] 691437006279 catalytic nucleophile [active] 691437006280 cell division suppressor protein YneA; Provisional; Region: PRK14125 691437006281 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118 691437006282 putative peptidoglycan binding site; other site 691437006283 LexA repressor; Validated; Region: PRK00215 691437006284 Helix-turn-helix domains; Region: HTH; cl00088 691437006285 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 691437006286 Catalytic site [active] 691437006287 glutamine synthetase, type I; Region: GlnA; TIGR00653 691437006288 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 691437006289 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 691437006290 Helix-Turn-Helix DNA binding domain of GlnR-like transcription regulators; Region: HTH_GlnR-like; cd01105 691437006291 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 691437006292 DNA binding residues [nucleotide binding] 691437006293 putative dimer interface [polypeptide binding]; other site 691437006294 Cystathionine beta-lyase family protein involved in aluminum resistance [Inorganic ion transport and metabolism]; Region: COG4100 691437006295 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 691437006296 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 691437006297 catalytic residue [active] 691437006298 GTP-binding protein HflX; Region: GTP_HflX; TIGR03156 691437006299 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 691437006300 HflX GTPase family; Region: HflX; cd01878 691437006301 G1 box; other site 691437006302 GTP/Mg2+ binding site [chemical binding]; other site 691437006303 Switch I region; other site 691437006304 G2 box; other site 691437006305 G3 box; other site 691437006306 Switch II region; other site 691437006307 G4 box; other site 691437006308 G5 box; other site 691437006309 Predicted membrane protein [Function unknown]; Region: COG2860 691437006310 UPF0126 domain; Region: UPF0126; pfam03458 691437006311 UPF0126 domain; Region: UPF0126; pfam03458 691437006312 EamA-like transporter family; Region: EamA; cl01037 691437006313 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 691437006314 EamA-like transporter family; Region: EamA; cl01037 691437006315 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 691437006316 putative active site [active] 691437006317 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 691437006318 acetyl-CoA acetyltransferases; Region: AcCoA-C-Actrans; TIGR01930 691437006319 dimer interface [polypeptide binding]; other site 691437006320 active site 691437006321 3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK05808 691437006322 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 691437006323 LDH/MDH dimer interface [polypeptide binding]; other site 691437006324 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 691437006325 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187 691437006326 AMP-binding enzyme; Region: AMP-binding; cl15778 691437006327 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 691437006328 CoA-transferase family III; Region: CoA_transf_3; pfam02515 691437006329 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 691437006330 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 691437006331 active site 691437006332 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187 691437006333 AMP-binding enzyme; Region: AMP-binding; cl15778 691437006334 AMP-binding enzyme; Region: AMP-binding; cl15778 691437006335 stage V sporulation protein K; Region: spore_V_K; TIGR02881 691437006336 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 691437006337 Walker A motif; other site 691437006338 ATP binding site [chemical binding]; other site 691437006339 Walker B motif; other site 691437006340 arginine finger; other site 691437006341 Hfq, an abundant, ubiquitous RNA-binding protein, functions as a pleiotrophic regulator of RNA metabolism in prokaryotes, required for transcription of some transcripts and degradation of others. Hfq binds small RNA molecules called riboregulators that...; Region: Hfq; cd01716 691437006342 Sm1 motif; other site 691437006343 intra - hexamer interaction site; other site 691437006344 inter - hexamer interaction site [polypeptide binding]; other site 691437006345 nucleotide binding pocket [chemical binding]; other site 691437006346 Sm2 motif; other site 691437006347 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 691437006348 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 691437006349 CHASE3 domain; Region: CHASE3; cl05000 691437006350 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 691437006351 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 691437006352 dimerization interface [polypeptide binding]; other site 691437006353 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 691437006354 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 691437006355 dimer interface [polypeptide binding]; other site 691437006356 putative CheW interface [polypeptide binding]; other site 691437006357 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 691437006358 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 691437006359 putative substrate translocation pore; other site 691437006360 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cl11420 691437006361 BCCT family transporter; Region: BCCT; cl00569 691437006362 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118 691437006363 putative peptidoglycan binding site; other site 691437006364 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 691437006365 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118 691437006366 putative peptidoglycan binding site; other site 691437006367 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 691437006368 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118 691437006369 putative peptidoglycan binding site; other site 691437006370 NlpC/P60 family; Region: NLPC_P60; cl11438 691437006371 DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095 691437006372 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 691437006373 ATP binding site [chemical binding]; other site 691437006374 Mg2+ binding site [ion binding]; other site 691437006375 G-X-G motif; other site 691437006376 MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is...; Region: MutL_Trans; cd00782 691437006377 ATP binding site [chemical binding]; other site 691437006378 MutL C terminal dimerisation domain; Region: MutL_C; cl07336 691437006379 DNA mismatch repair protein MutS; Provisional; Region: PRK05399 691437006380 MutS domain I; Region: MutS_I; pfam01624 691437006381 MutS domain II; Region: MutS_II; pfam05188 691437006382 MutS family domain IV; Region: MutS_IV; pfam05190 691437006383 MutS1 homolog in eukaryotes. The MutS protein initiates DNA mismatch repair by recognizing mispaired and unpaired bases embedded in duplex DNA and activating endo- and exonucleases to remove the mismatch. Members of the MutS family possess C-terminal...; Region: ABC_MutS1; cd03284 691437006384 Walker A/P-loop; other site 691437006385 ATP binding site [chemical binding]; other site 691437006386 Q-loop/lid; other site 691437006387 ABC transporter signature motif; other site 691437006388 Walker B; other site 691437006389 D-loop; other site 691437006390 H-loop/switch region; other site 691437006391 Outer spore coat protein E (CotE); Region: CotE; pfam10628 691437006392 Protein of unknown function (DUF964); Region: DUF964; cl01483 691437006393 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14327 691437006394 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 691437006395 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 691437006396 FeS/SAM binding site; other site 691437006397 TRAM domain; Region: TRAM; cl01282 691437006398 2-oxoglutarate ferredoxin oxidoreductase subunit beta; Reviewed; Region: PRK11867 691437006399 Thiamine pyrophosphate (TPP family), 2-oxoglutarate ferredoxin oxidoreductase (OGFOR) subfamily, TPP-binding module; OGFOR catalyzes the oxidative decarboxylation of 2-oxo-acids, with ferredoxin acting as an electron acceptor. In the TCA cycle, OGFOR...; Region: TPP_OGFOR; cd03375 691437006400 TPP-binding site [chemical binding]; other site 691437006401 Pyruvate ferredoxin oxidoreductase beta subunit C terminal; Region: PFO_beta_C; pfam12367 691437006402 2-oxoacid:acceptor oxidoreductase, alpha subunit; Region: OAFO_sf; TIGR03710 691437006403 Pyruvate ferredoxin/flavodoxin oxidoreductase; Region: POR; cl00546 691437006404 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 691437006405 dimer interface [polypeptide binding]; other site 691437006406 PYR/PP interface [polypeptide binding]; other site 691437006407 TPP binding site [chemical binding]; other site 691437006408 substrate binding site [chemical binding]; other site 691437006409 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 691437006410 renal dipeptidase (rDP), best studied in mammals and also called membrane or microsomal dipeptidase, is a membrane-bound glycoprotein hydrolyzing dipeptides and is involved in hydrolytic metabolism of penem and carbapenem beta-lactam antibiotics; Region: rDP_like; cd01301 691437006411 active site 691437006412 dimer interface [polypeptide binding]; other site 691437006413 Stage V sporulation protein S (SpoVS); Region: SpoVS; cl01005 691437006414 Deinococcus radiodurans DR1281 and related proteins, metallophosphatase domain; Region: MPP_DR1281; cd07382 691437006415 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 691437006416 putative active site [active] 691437006417 metal binding site [ion binding]; metal-binding site 691437006418 homodimer binding site [polypeptide binding]; other site 691437006419 phosphodiesterase; Provisional; Region: PRK12704 691437006420 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 691437006421 Cation efflux family; Region: Cation_efflux; cl00316 691437006422 Uncharacterized protein family (UPF0236); Region: UPF0236; pfam06782 691437006423 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 691437006424 Walker B motif; other site 691437006425 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 691437006426 Walker A motif; other site 691437006427 ATP binding site [chemical binding]; other site 691437006428 competence damage-inducible protein A; Provisional; Region: PRK00549 691437006429 Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885 691437006430 putative MPT binding site; other site 691437006431 Competence-damaged protein; Region: CinA; cl00666 691437006432 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 691437006433 Predicted transcriptional regulator contains Xre-like HTH domain [Function unknown]; Region: COG1426 691437006434 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 691437006435 non-specific DNA binding site [nucleotide binding]; other site 691437006436 salt bridge; other site 691437006437 sequence-specific DNA binding site [nucleotide binding]; other site 691437006438 Domain of unknown function (DUF4115); Region: DUF4115; pfam13464 691437006439 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 691437006440 Protein of unknown function (DUF3388); Region: DUF3388; pfam11868 691437006441 Protein of unknown function (DUF3243); Region: DUF3243; pfam11588 691437006442 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 691437006443 classical (c) SDRs; Region: SDR_c; cd05233 691437006444 NAD(P) binding site [chemical binding]; other site 691437006445 active site 691437006446 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 691437006447 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 691437006448 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 691437006449 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 691437006450 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 691437006451 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 691437006452 TM-ABC transporter signature motif; other site 691437006453 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 691437006454 TM-ABC transporter signature motif; other site 691437006455 ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845 691437006456 This family represents the domain I of the carbohydrate uptake proteins that transport only monosaccharides (Monos). The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and hexoses...; Region: ABC_Carb_Monos_I; cd03216 691437006457 Walker A/P-loop; other site 691437006458 ATP binding site [chemical binding]; other site 691437006459 Q-loop/lid; other site 691437006460 ABC transporter signature motif; other site 691437006461 Walker B; other site 691437006462 D-loop; other site 691437006463 H-loop/switch region; other site 691437006464 This family represents domain II of the carbohydrate uptake proteins that transport only monosaccharides (Monos). The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and hexoses; Region: ABC_Carb_Monos_II; cd03215 691437006465 Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744 691437006466 Periplasmic binding domain of basic membrane lipoprotein, PnrA, in Treponema pallidum and its homologs from other bacteria and Archaea; Region: PBP1_BmpA_PnrA_like; cd06354 691437006467 ligand binding site [chemical binding]; other site 691437006468 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 691437006469 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 691437006470 DNA-binding site [nucleotide binding]; DNA binding site 691437006471 UTRA domain; Region: UTRA; cl01230 691437006472 Domain of unknown function (DUF4117); Region: DUF4117; pfam13491 691437006473 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 691437006474 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 691437006475 Ftsk gamma domain; Region: Ftsk_gamma; cl09645 691437006476 YlzJ-like protein; Region: YlzJ; pfam14035 691437006477 Clp protease; Region: CLP_protease; pfam00574 691437006478 Caseinolytic protease (ClpP) is an ATP-dependent protease; Region: Clp_protease_like; cl15763 691437006479 active site 691437006480 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 691437006481 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 691437006482 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 691437006483 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 691437006484 dihydrodipicolinate synthase; Region: dapA; TIGR00674 691437006485 dimer interface [polypeptide binding]; other site 691437006486 active site 691437006487 catalytic residue [active] 691437006488 aspartate kinase I; Reviewed; Region: PRK08210 691437006489 Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452 691437006490 nucleotide binding site [chemical binding]; other site 691437006491 substrate binding site [chemical binding]; other site 691437006492 ACT domains of the diaminopimelate-sensitive aspartokinase (AK) isoenzyme AKI; Region: ACT_AKi-DapG-BS_1; cd04914 691437006493 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 691437006494 aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874 691437006495 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 691437006496 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; cl15856 691437006497 Flavoprotein; Region: Flavoprotein; cl08021 691437006498 dipicolinate synthase subunit A; Reviewed; Region: PRK08306 691437006499 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 691437006500 Photosynthetic reaction center (RC) complex, subunit H; RC is an integral membrane protein-pigment complex which catalyzes light-induced reduction of ubiquinone to ubiquinol, generating a transmembrane electrochemical gradient of protons used to produce...; Region: PRCH; cl09959 691437006501 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 691437006502 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 691437006503 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 691437006504 probable sporulation protein, polysaccharide deacetylase family; Region: spore_ylxY; TIGR02873 691437006505 Putative catalytic NodB homology domain of uncharacterized protein YlxY from Bacillus subtilis and its bacterial homologs; Region: CE4_BsYlxY_like; cd10950 691437006506 NodB motif; other site 691437006507 polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824 691437006508 Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363 691437006509 RNase E interface [polypeptide binding]; other site 691437006510 trimer interface [polypeptide binding]; other site 691437006511 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 691437006512 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 691437006513 RNase E interface [polypeptide binding]; other site 691437006514 trimer interface [polypeptide binding]; other site 691437006515 active site 691437006516 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 691437006517 putative nucleic acid binding region [nucleotide binding]; other site 691437006518 G-X-X-G motif; other site 691437006519 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 691437006520 RNA binding site [nucleotide binding]; other site 691437006521 domain interface; other site 691437006522 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 691437006523 16S/18S rRNA binding site [nucleotide binding]; other site 691437006524 S13e-L30e interaction site [polypeptide binding]; other site 691437006525 25S rRNA binding site [nucleotide binding]; other site 691437006526 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 691437006527 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 691437006528 active site 691437006529 Riboflavin kinase; Region: Flavokinase; cl03312 691437006530 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK01550 691437006531 PseudoU_synth_EcTruB: Pseudouridine synthase, Escherichia coli TruB like. This group consists of bacterial pseudouridine synthases similar to E. coli TruB and Mycobacterium tuberculosis TruB. Pseudouridine synthases catalyze the isomerization of specific...; Region: PseudoU_synth_EcTruB; cd02573 691437006532 RNA binding site [nucleotide binding]; other site 691437006533 active site 691437006534 Ribosome-binding factor A; Region: RBFA; cl00542 691437006535 Protein of unknown function (DUF503); Region: DUF503; cl00669 691437006536 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 691437006537 translation initiation factor IF-2; Region: IF-2; TIGR00487 691437006538 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 691437006539 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 691437006540 G1 box; other site 691437006541 putative GEF interaction site [polypeptide binding]; other site 691437006542 GTP/Mg2+ binding site [chemical binding]; other site 691437006543 Switch I region; other site 691437006544 G2 box; other site 691437006545 G3 box; other site 691437006546 Switch II region; other site 691437006547 G4 box; other site 691437006548 G5 box; other site 691437006549 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 691437006550 Translation-initiation factor 2; Region: IF-2; pfam11987 691437006551 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 691437006552 Ribosomal protein L7Ae/L30e/S12e/Gadd45 family; Region: Ribosomal_L7Ae; cl00600 691437006553 Ylxr homologs; group of conserved hypothetical bacterial proteins of unknown function; structure revealed putative RNA binding cleft; proteins are encoded by an operon that includes other proteins involved in transcription and/or translation; Region: YlxR; cd00279 691437006554 putative RNA binding cleft [nucleotide binding]; other site 691437006555 transcription elongation factor NusA; Provisional; Region: nusA; PRK12327 691437006556 NusA N-terminal domain; Region: NusA_N; pfam08529 691437006557 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 691437006558 RNA binding site [nucleotide binding]; other site 691437006559 homodimer interface [polypeptide binding]; other site 691437006560 K homology RNA-binding domain, type I. KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains that...; Region: KH-I; cl00098 691437006561 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 691437006562 G-X-X-G motif; other site 691437006563 ribosome maturation protein RimP; Reviewed; Region: PRK00092 691437006564 The eukaryotic Sm and Sm-like (LSm) proteins associate with RNA to form the core domain of the ribonucleoprotein particles involved in a variety of RNA processing events including pre-mRNA splicing, telomere replication, and mRNA degradation. Members of...; Region: Sm_like; cl00259 691437006565 YxlS is a Bacillus subtilis gene of unknown function with two domains that each have an alpha/beta fold. The N-terminal domain is composed of two alpha-helices and a three-stranded beta-sheet, while the C-terminal domain is composed of one alpha-helix...; Region: YlxS_C; cd01734 691437006566 Sm1 motif; other site 691437006567 predicted subunit interaction site [polypeptide binding]; other site 691437006568 RNA binding pocket [nucleotide binding]; other site 691437006569 Sm2 motif; other site 691437006570 DNA polymerase III PolC; Validated; Region: polC; PRK00448 691437006571 DNA polymerase III polC-type N-terminus; Region: DNA_pol3_alph_N; pfam11490 691437006572 polC_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold nucleic acid binding domain of Bacillus subtilis type C replicative DNA polymerase III alpha subunit (polC). Replication in B. subtilis and Staphylococcus aureus requires two...; Region: polC_OBF; cd04484 691437006573 generic binding surface I; other site 691437006574 generic binding surface II; other site 691437006575 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 691437006576 active site 691437006577 catalytic site [active] 691437006578 substrate binding site [chemical binding]; other site 691437006579 Bacterial DNA polymerase III alpha subunit; Region: DNA_pol3_alpha; pfam07733 691437006580 prolyl-tRNA synthetase; Provisional; Region: PRK09194 691437006581 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent formation of...; Region: ProRS_core_prok; cd00779 691437006582 dimer interface [polypeptide binding]; other site 691437006583 motif 1; other site 691437006584 active site 691437006585 motif 2; other site 691437006586 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334 691437006587 putative deacylase active site [active] 691437006588 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it attaches...; Region: class_II_aaRS-like_core; cl00268 691437006589 active site 691437006590 motif 3; other site 691437006591 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 691437006592 anticodon binding site; other site 691437006593 RIP metalloprotease RseP; Region: TIGR00054 691437006594 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 691437006595 active site 691437006596 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 691437006597 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 691437006598 protein binding site [polypeptide binding]; other site 691437006599 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 691437006600 putative substrate binding region [chemical binding]; other site 691437006601 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447 691437006602 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 691437006603 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 691437006604 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 691437006605 Cytidylyltransferase family; Region: CTP_transf_1; cl00347 691437006606 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475 691437006607 Putative undecaprenyl diphosphate synthase; Region: Prenyltransf; pfam01255 691437006608 catalytic residue [active] 691437006609 putative FPP diphosphate binding site; other site 691437006610 putative FPP binding hydrophobic cleft; other site 691437006611 dimer interface [polypeptide binding]; other site 691437006612 putative IPP diphosphate binding site; other site 691437006613 ribosome recycling factor; Reviewed; Region: frr; PRK00083 691437006614 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are 'recycled' and ready for another round of...; Region: RRF; cd00520 691437006615 hinge region; other site 691437006616 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 691437006617 putative nucleotide binding site [chemical binding]; other site 691437006618 uridine monophosphate binding site [chemical binding]; other site 691437006619 homohexameric interface [polypeptide binding]; other site 691437006620 elongation factor Ts; Provisional; Region: tsf; PRK09377 691437006621 Ubiquitin Associated domain. The UBA domain is a commonly occurring sequence motif in some members of the ubiquitination pathway, UV excision repair proteins, and certain protein kinases. Although its specific role is so far unknown, it has been...; Region: UBA; cl00153 691437006622 Elongation factor TS; Region: EF_TS; pfam00889 691437006623 Elongation factor TS; Region: EF_TS; pfam00889 691437006624 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 691437006625 rRNA interaction site [nucleotide binding]; other site 691437006626 S8 interaction site; other site 691437006627 putative laminin-1 binding site; other site 691437006628 Helix-turn-helix domains; Region: HTH; cl00088 691437006629 RNA polymerase sigma factor SigD; Validated; Region: PRK07670 691437006630 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 691437006631 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 691437006632 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 691437006633 DNA binding residues [nucleotide binding] 691437006634 CheD chemotactic sensory transduction; Region: CheD; cl00810 691437006635 Chemotaxis protein CheC, inhibitor of MCP methylation [Cell motility and secretion / Signal transduction mechanisms]; Region: CheC; COG1776 691437006636 Chemotaxis phosphatase CheX; Region: CheX; cl15816 691437006637 Chemotaxis phosphatase CheX; Region: CheX; cl15816 691437006638 CheW, a small regulator protein, unique to the chemotaxis signalling in prokaryotes and archea. CheW interacts with the histidine kinase CheA, most likely with the related regulatory domain of CheA. CheW is proposed to form signalling arrays together...; Region: CheW; cd00732 691437006639 putative CheA interaction surface; other site 691437006640 Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643 691437006641 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 691437006642 putative binding surface; other site 691437006643 active site 691437006644 P2 response regulator binding domain; Region: P2; pfam07194 691437006645 Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895 691437006646 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 691437006647 ATP binding site [chemical binding]; other site 691437006648 Mg2+ binding site [ion binding]; other site 691437006649 G-X-G motif; other site 691437006650 CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731 691437006651 chemotaxis-specific methylesterase; Provisional; Region: PRK00742 691437006652 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 691437006653 active site 691437006654 phosphorylation site [posttranslational modification] 691437006655 intermolecular recognition site; other site 691437006656 dimerization interface [polypeptide binding]; other site 691437006657 CheB methylesterase; Region: CheB_methylest; pfam01339 691437006658 Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455 691437006659 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 691437006660 FleN is a member of the Fer4_NifH superfamily. It shares the common function as an ATPase, with the ATP-binding domain at the N-terminus. In Pseudomonas aeruginosa, FleN gene is involved in regulating the number of flagella and chemotactic motility by...; Region: FleN-like; cd02038 691437006661 flagellar biosynthesis regulator FlhF; Validated; Region: flhF; PRK05703 691437006662 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 691437006663 flagellar biosynthesis protein FlhA; Validated; Region: flhA; cl07980 691437006664 FHIPEP family; Region: FHIPEP; pfam00771 691437006665 flagellar biosynthesis protein FlhB; Reviewed; Region: flhB; PRK05702 691437006666 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257; cl15822 691437006667 Bacterial export proteins, family 1; Region: Bac_export_1; cl00734 691437006668 Bacterial export proteins, family 3; Region: Bac_export_3; cl00867 691437006669 FliP family; Region: FliP; cl00593 691437006670 Flagellar biosynthesis protein, FliO; Region: FliO; cl01247 691437006671 Response regulator receiver domain; Region: Response_reg; pfam00072 691437006672 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 691437006673 active site 691437006674 phosphorylation site [posttranslational modification] 691437006675 intermolecular recognition site; other site 691437006676 dimerization interface [polypeptide binding]; other site 691437006677 flagellar motor switch protein; Validated; Region: PRK08119 691437006678 Chemotaxis phosphatase CheX; Region: CheX; cl15816 691437006679 Chemotaxis phosphatase CheX; Region: CheX; cl15816 691437006680 Surface presentation of antigens (SPOA); Region: SpoA; cl00819 691437006681 flagellar motor switch protein FliM; Validated; Region: fliM; PRK06666 691437006682 Surface presentation of antigens (SPOA); Region: SpoA; cl00819 691437006683 flagellar basal body-associated protein FliL; Reviewed; Region: fliL; PRK07718 691437006684 Flagellar basal body-associated protein FliL; Region: FliL; cl00681 691437006685 Flagellar protein (FlbD); Region: FlbD; cl00683 691437006686 flagellar basal body rod protein FlgG; Provisional; Region: flgG; PRK12636 691437006687 Flagella basal body rod protein; Region: Flg_bb_rod; cl15793 691437006688 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; cl15855 691437006689 flagellar basal body rod modification protein; Provisional; Region: flgD; PRK09618 691437006690 Flagellar hook capping protein - N-terminal region; Region: FlgD; pfam03963 691437006691 Flagellar hook-length control protein FliK; Region: Flg_hook; cl15269 691437006692 AAA domain; Region: AAA_13; pfam13166 691437006693 MgtE intracellular N domain; Region: MgtE_N; cl15244 691437006694 flagellar biosynthesis chaperone; Validated; Region: fliJ; cl09161 691437006695 flagellar export protein FliJ; Region: flagell_FliJ; TIGR02473 691437006696 flagellum-specific ATP synthase; Validated; Region: fliI; PRK07721 691437006697 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; cl15275 691437006698 Flagellum-specific ATPase/type III secretory pathway virulence-related protein. This group of ATPases are responsible for the export of flagellum and virulence-related proteins. The bacterial flagellar motor is similar to the F0F1-ATPase, in that they...; Region: ATPase_flagellum-secretory_path_III; cd01136 691437006699 Walker A motif/ATP binding site; other site 691437006700 Walker B motif; other site 691437006701 flagellar assembly protein FliH; Region: FliH_bacil; TIGR03825 691437006702 Flagellar assembly protein FliH; Region: FliH; pfam02108 691437006703 flagellar motor switch protein G; Validated; Region: fliG; PRK05686 691437006704 MgtE intracellular N domain; Region: MgtE_N; cl15244 691437006705 FliG C-terminal domain; Region: FliG_C; pfam01706 691437006706 Secretory protein of YscJ/FliF family; Region: YscJ_FliF; cl01907 691437006707 Flagellar M-ring protein C-terminal; Region: YscJ_FliF_C; pfam08345 691437006708 Flagellar hook-basal body complex protein FliE; Region: FliE; cl09139 691437006709 flagellar basal body rod protein FlgC; Reviewed; Region: flgC; PRK05681 691437006710 Flagella basal body rod protein; Region: Flg_bb_rod; cl15793 691437006711 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; cl15855 691437006712 flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK05680 691437006713 Flagella basal body rod protein; Region: Flg_bb_rod; cl15793 691437006714 transcriptional repressor CodY; Validated; Region: PRK04158 691437006715 CodY GAF-like domain; Region: CodY; pfam06018 691437006716 Helix-turn-helix domains; Region: HTH; cl00088 691437006717 ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201 691437006718 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 691437006719 Walker A motif; other site 691437006720 ATP binding site [chemical binding]; other site 691437006721 Walker B motif; other site 691437006722 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 691437006723 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; cl11083 691437006724 Protease HslV and the ATPase/chaperone HslU are part of an ATP-dependent proteolytic system that is the prokaryotic homolog of the proteasome. HslV is a dimer of hexamers (a dodecamer) that forms a central proteolytic chamber with active sites on the...; Region: protease_HslV; cd01913 691437006725 active site 691437006726 HslU subunit interaction site [polypeptide binding]; other site 691437006727 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 691437006728 XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798 691437006729 active site 691437006730 Int/Topo IB signature motif; other site 691437006731 DNA topoisomerase I; Validated; Region: PRK05582 691437006732 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 691437006733 active site 691437006734 interdomain interaction site; other site 691437006735 putative metal-binding site [ion binding]; other site 691437006736 nucleotide binding site [chemical binding]; other site 691437006737 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 691437006738 domain I; other site 691437006739 DNA binding groove [nucleotide binding] 691437006740 phosphate binding site [ion binding]; other site 691437006741 domain II; other site 691437006742 domain III; other site 691437006743 nucleotide binding site [chemical binding]; other site 691437006744 catalytic site [active] 691437006745 domain IV; other site 691437006746 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 691437006747 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 691437006748 Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695 691437006749 DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481 691437006750 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 691437006751 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 691437006752 CoA-ligase; Region: Ligase_CoA; cl02894 691437006753 succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696 691437006754 ATP-grasp domain; Region: ATP-grasp_4; cl03087 691437006755 CoA-ligase; Region: Ligase_CoA; cl02894 691437006756 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257; cl15822 691437006757 Flagellar hook-length control protein FliK; Region: Flg_hook; cl15269 691437006758 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 691437006759 RNA/DNA hybrid binding site [nucleotide binding]; other site 691437006760 active site 691437006761 GTPase YlqF; Reviewed; Region: rbgA; PRK09563 691437006762 Circularly permuted YlqF GTPase; Region: YlqF; cd01856 691437006763 GTP/Mg2+ binding site [chemical binding]; other site 691437006764 G4 box; other site 691437006765 G5 box; other site 691437006766 G1 box; other site 691437006767 Switch I region; other site 691437006768 G2 box; other site 691437006769 G3 box; other site 691437006770 Switch II region; other site 691437006771 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 691437006772 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 691437006773 Catalytic site [active] 691437006774 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 691437006775 Ribosomal protein L19; Region: Ribosomal_L19; cl00406 691437006776 tRNA (Guanine-1)-methyltransferase; Region: tRNA_m1G_MT; cl00407 691437006777 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 691437006778 RimM N-terminal domain; Region: RimM; pfam01782 691437006779 Photosynthetic reaction center (RC) complex, subunit H; RC is an integral membrane protein-pigment complex which catalyzes light-induced reduction of ubiquinone to ubiquinol, generating a transmembrane electrochemical gradient of protons used to produce...; Region: PRCH; cl09959 691437006780 Predicted RNA-binding protein (contains KH domain) [General function prediction only]; Region: COG1837 691437006781 K homology RNA-binding domain, type I. KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains that...; Region: KH-I; cl00098 691437006782 Ribosomal protein S16; Region: Ribosomal_S16; cl00368 691437006783 signal recognition particle protein; Provisional; Region: PRK10867 691437006784 SRP54-type protein, helical bundle domain; Region: SRP54_N; cl03758 691437006785 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 691437006786 GTP binding site [chemical binding]; other site 691437006787 Signal peptide binding domain; Region: SRP_SPB; pfam02978 691437006788 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 691437006789 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 691437006790 SRP54-type protein, helical bundle domain; Region: SRP54_N; cl03758 691437006791 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 691437006792 P loop; other site 691437006793 GTP binding site [chemical binding]; other site 691437006794 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 691437006795 Barmotin is a tight junction-associated protein expressed in rat epithelial cells which is thought to have an important regulatory role in tight junction barrier function. Barmotin belongs to the SMC protein family. SMC proteins are large; Region: ABC_SMC_barmotin; cd03278 691437006796 Walker A/P-loop; other site 691437006797 ATP binding site [chemical binding]; other site 691437006798 Q-loop/lid; other site 691437006799 SMC proteins Flexible Hinge Domain; Region: SMC_hinge; cl05797 691437006800 Barmotin is a tight junction-associated protein expressed in rat epithelial cells which is thought to have an important regulatory role in tight junction barrier function. Barmotin belongs to the SMC protein family. SMC proteins are large; Region: ABC_SMC_barmotin; cd03278 691437006801 ABC transporter signature motif; other site 691437006802 Walker B; other site 691437006803 D-loop; other site 691437006804 H-loop/switch region; other site 691437006805 ribonuclease III; Reviewed; Region: rnc; PRK00102 691437006806 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 691437006807 dimerization interface [polypeptide binding]; other site 691437006808 active site 691437006809 metal binding site [ion binding]; metal-binding site 691437006810 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 691437006811 dsRNA binding site [nucleotide binding]; other site 691437006812 Phosphopantetheine attachment site; Region: PP-binding; cl09936 691437006813 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 691437006814 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 691437006815 NAD(P) binding site [chemical binding]; other site 691437006816 homotetramer interface [polypeptide binding]; other site 691437006817 homodimer interface [polypeptide binding]; other site 691437006818 active site 691437006819 Acyl transferase domain; Region: Acyl_transf_1; cl08282 691437006820 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 691437006821 Phosphate acetyl/butaryl transferase; Region: PTA_PTB; cl00390 691437006822 fatty acid biosynthesis transcriptional regulator; Provisional; Region: PRK04424 691437006823 Helix-turn-helix domains; Region: HTH; cl00088 691437006824 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 691437006825 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 691437006826 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 691437006827 generic binding surface II; other site 691437006828 ssDNA binding site; other site 691437006829 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 691437006830 ATP binding site [chemical binding]; other site 691437006831 putative Mg++ binding site [ion binding]; other site 691437006832 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 691437006833 nucleotide binding region [chemical binding]; other site 691437006834 ATP-binding site [chemical binding]; other site 691437006835 Serine dehydratase alpha chain; Region: SDH_alpha; cl12120 691437006836 L-serine deaminase [Amino acid transport and metabolism]; Region: SdaA; COG1760 691437006837 L-serine dehydratase, iron-sulfur-dependent, beta subunit; Region: sda_beta; TIGR00719 691437006838 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 691437006839 C-terminal ACT domain of the L-serine dehydratase (LSD), iron-sulfur-dependent, beta subunit; Region: ACT_LSD; cd04903 691437006840 putative L-serine binding site [chemical binding]; other site 691437006841 DAK2 domain fusion protein YloV; Region: YloV; TIGR03599 691437006842 DAK2 domain; Region: Dak2; cl03685 691437006843 Uncharacterized protein, DegV family COG1307; Region: DegV; cl00577 691437006844 Asp23 family; Region: Asp23; cl00574 691437006845 Ribosomal L28 family; Region: Ribosomal_L28; cl00367 691437006846 Stage V sporulation protein family; Region: SpoV; cl15455 691437006847 Thiamine pyrophosphokinase; Region: TPK; cd07995 691437006848 thiamine pyrophosphokinase; Region: thi_PPkinase; TIGR01378 691437006849 active site 691437006850 dimerization interface [polypeptide binding]; other site 691437006851 thiamine binding site [chemical binding]; other site 691437006852 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 691437006853 ribulose-phosphate 3-epimerase; Region: rpe; TIGR01163 691437006854 substrate binding site [chemical binding]; other site 691437006855 hexamer interface [polypeptide binding]; other site 691437006856 metal binding site [ion binding]; metal-binding site 691437006857 S1_YloQ_GTPase: YloQ GTase family (also known as YjeQ and CpgA), S1-like RNA-binding domain. Proteins in the YloQ GTase family bind the ribosome and have GTPase activity. The precise role of this family is unknown. The protein structure is composed of...; Region: S1_YloQ_GTPase; cd04466 691437006858 GTPase RsgA; Reviewed; Region: PRK00098 691437006859 RNA binding site [nucleotide binding]; other site 691437006860 homodimer interface [polypeptide binding]; other site 691437006861 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 691437006862 GTPase/Zn-binding domain interface [polypeptide binding]; other site 691437006863 GTP/Mg2+ binding site [chemical binding]; other site 691437006864 G4 box; other site 691437006865 G5 box; other site 691437006866 G1 box; other site 691437006867 Switch I region; other site 691437006868 G2 box; other site 691437006869 G3 box; other site 691437006870 Switch II region; other site 691437006871 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 691437006872 Catalytic domain of Protein Kinases; Region: PKc; cd00180 691437006873 active site 691437006874 ATP binding site [chemical binding]; other site 691437006875 substrate binding site [chemical binding]; other site 691437006876 activation loop (A-loop); other site 691437006877 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2815 691437006878 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 691437006879 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 691437006880 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 691437006881 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 691437006882 Protein phosphatase 2C; Region: PP2C; pfam00481 691437006883 active site 691437006884 ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK14455 691437006885 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 691437006886 FeS/SAM binding site; other site 691437006887 16S rRNA methyltransferase B; Provisional; Region: PRK14902 691437006888 RNA binding domain of NusB (N protein-Utilization Substance B) and Sun (also known as RrmB or Fmu) proteins. This family includes two orthologous groups exemplified by the transcription termination factor NusB and the N-terminal domain of the...; Region: NusB_Sun; cl00223 691437006889 putative RNA binding site [nucleotide binding]; other site 691437006890 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 691437006891 S-adenosylmethionine binding site [chemical binding]; other site 691437006892 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 691437006893 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 691437006894 putative active site [active] 691437006895 substrate binding site [chemical binding]; other site 691437006896 putative cosubstrate binding site; other site 691437006897 catalytic site [active] 691437006898 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 691437006899 substrate binding site [chemical binding]; other site 691437006900 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 691437006901 active site 691437006902 catalytic residues [active] 691437006903 metal binding site [ion binding]; metal-binding site 691437006904 primosome assembly protein PriA; Validated; Region: PRK05580 691437006905 primosome assembly protein PriA; Validated; Region: PRK05580 691437006906 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 691437006907 ATP binding site [chemical binding]; other site 691437006908 putative Mg++ binding site [ion binding]; other site 691437006909 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 691437006910 nucleotide binding region [chemical binding]; other site 691437006911 ATP-binding site [chemical binding]; other site 691437006912 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 691437006913 Flavoprotein; Region: Flavoprotein; cl08021 691437006914 DNA / pantothenate metabolism flavoprotein; Region: DFP; cl04410 691437006915 RNA polymerase Rpb6; Region: RNA_pol_Rpb6; cl14651 691437006916 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 691437006917 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 691437006918 catalytic site [active] 691437006919 G-X2-G-X-G-K; other site 691437006920 Domain of unknown function (DUF370); Region: DUF370; cl00898 691437006921 hypothetical protein; Provisional; Region: PRK11820 691437006922 YicC-like family, N-terminal region; Region: YicC_N; pfam03755 691437006923 Domain of unknown function (DUF1732); Region: DUF1732; pfam08340 691437006924 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 691437006925 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; cl02930 691437006926 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 691437006927 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 691437006928 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 691437006929 motif II; other site 691437006930 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 691437006931 Fibronectin-binding protein A N-terminus (FbpA); Region: FbpA; pfam05833 691437006932 Domain of unknown function (DUF814); Region: DUF814; pfam05670 691437006933 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 691437006934 putative active site [active] 691437006935 PIN domain of ribonucleases (toxins), VapC, FitB, and PAE0151 of bacterial and archaeal toxin/antitoxin-like operons, and other similar homologs; Region: PIN_VapC-like; cd09861 691437006936 putative active site [active] 691437006937 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 691437006938 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 691437006939 catalytic residue [active] 691437006940 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 691437006941 extended (e) SDRs; Region: SDR_e; cd08946 691437006942 NAD(P) binding site [chemical binding]; other site 691437006943 active site 691437006944 substrate binding site [chemical binding]; other site 691437006945 Trehalose and maltose hydrolases (possible phosphorylases) [Carbohydrate transport and metabolism]; Region: ATH1; COG1554 691437006946 Glycosyl hydrolase family 65, N-terminal domain; Region: Glyco_hydro_65N; pfam03636 691437006947 Glycosyl hydrolase family 65 central catalytic domain; Region: Glyco_hydro_65m; pfam03632 691437006948 Glycosyl hydrolase family 65, C-terminal domain; Region: Glyco_hydro_65C; pfam03633 691437006949 Transposase domain (DUF772); Region: DUF772; cl15789 691437006950 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 691437006951 Transposase domain (DUF772); Region: DUF772; cl15789 691437006952 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 691437006953 Transposase [DNA replication, recombination, and repair]; Region: COG5421 691437006954 beta-phosphoglucomutase; Region: bPGM; TIGR01990 691437006955 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 691437006956 H+ Antiporter protein; Region: 2A0121; TIGR00900 691437006957 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 691437006958 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 691437006959 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 691437006960 Coenzyme A binding pocket [chemical binding]; other site 691437006961 hypothetical protein; Provisional; Region: PRK07206 691437006962 ATP-grasp domain; Region: ATP-grasp_4; cl03087 691437006963 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 691437006964 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 691437006965 pyridoxal 5'-phosphate binding site [chemical binding]; other site 691437006966 homodimer interface [polypeptide binding]; other site 691437006967 catalytic residue [active] 691437006968 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 691437006969 Coenzyme A binding pocket [chemical binding]; other site 691437006970 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 691437006971 active site 691437006972 nucleotide binding site [chemical binding]; other site 691437006973 HIGH motif; other site 691437006974 KMSKS motif; other site 691437006975 Glutamate-1-semialdehyde aminotransferase [Coenzyme metabolism]; Region: HemL; COG0001 691437006976 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 691437006977 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 691437006978 catalytic residue [active] 691437006979 Transposase domain (DUF772); Region: DUF772; cl15789 691437006980 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 691437006981 Transposase domain (DUF772); Region: DUF772; cl15789 691437006982 H+ Antiporter protein; Region: 2A0121; TIGR00900 691437006983 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 691437006984 putative substrate translocation pore; other site 691437006985 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 691437006986 Transposase; Region: DDE_Tnp_ISL3; pfam01610 691437006987 orotate phosphoribosyltransferase; Validated; Region: pyrE; PRK00455 691437006988 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 691437006989 active site 691437006990 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase contains two...; Region: OMP_decarboxylase_like; cd04725 691437006991 active site 691437006992 dimer interface [polypeptide binding]; other site 691437006993 dihydroorotate dehydrogenase (subfamily 1) family protein; Region: pyrD_sub1_fam; TIGR01037 691437006994 Dihydroorotate dehydrogenase (DHOD) class 1B FMN-binding domain. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine...; Region: DHOD_1B_like; cd04740 691437006995 heterodimer interface [polypeptide binding]; other site 691437006996 active site 691437006997 FMN binding site [chemical binding]; other site 691437006998 homodimer interface [polypeptide binding]; other site 691437006999 substrate binding site [chemical binding]; other site 691437007000 dihydroorotate dehydrogenase electron transfer subunit; Reviewed; Region: PRK00054 691437007001 FAD/NAD binding domain in the electron transfer subunit of dihydroorotate dehydrogenase. Dihydroorotate dehydrogenases (DHODs) catalyze the only redox reaction in pyrimidine de novo biosynthesis. They catalyze the oxidation of (S)-dihydroorotate to...; Region: DHOD_e_trans; cd06218 691437007002 FAD binding pocket [chemical binding]; other site 691437007003 FAD binding motif [chemical binding]; other site 691437007004 phosphate binding motif [ion binding]; other site 691437007005 beta-alpha-beta structure motif; other site 691437007006 NAD binding pocket [chemical binding]; other site 691437007007 Iron coordination center [ion binding]; other site 691437007008 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 691437007009 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 691437007010 ATP-grasp domain; Region: ATP-grasp_4; cl03087 691437007011 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 691437007012 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 691437007013 ATP-grasp domain; Region: ATP-grasp_4; cl03087 691437007014 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 691437007015 IMP binding site; other site 691437007016 dimer interface [polypeptide binding]; other site 691437007017 interdomain contacts; other site 691437007018 partial ornithine binding site; other site 691437007019 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 691437007020 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; cl03056 691437007021 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 691437007022 catalytic site [active] 691437007023 subunit interface [polypeptide binding]; other site 691437007024 dihydroorotase; Validated; Region: pyrC; PRK09357 691437007025 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 691437007026 Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317 691437007027 active site 691437007028 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 691437007029 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 691437007030 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 691437007031 pyrimidine utilization transport protein G; Region: RutG; TIGR03616 691437007032 uracil-xanthine permease; Region: ncs2; TIGR00801 691437007033 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 691437007034 active site 691437007035 pseudouridine synthase, RluA family; Region: rluA_subfam; TIGR00005 691437007036 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 691437007037 RNA binding surface [nucleotide binding]; other site 691437007038 PseudoU_synth_RsuA/RluD: Pseudouridine synthase, RsuA/RluD family. This group is comprised of eukaryotic, bacterial and archeal proteins similar to eight site specific Escherichia coli pseudouridine synthases: RsuA, RluA, RluB, RluC, RluD, RluE, RluF and...; Region: PseudoU_synth_RluCD_like; cd02869 691437007039 active site 691437007040 Signal peptidase (SPase) II; Region: Peptidase_A8; cl00458 691437007041 lipoprotein signal peptidase; Provisional; Region: PRK14787 691437007042 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743 691437007043 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 691437007044 HIGH motif; other site 691437007045 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 691437007046 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 691437007047 active site 691437007048 KMSKS motif; other site 691437007049 Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960 691437007050 tRNA binding surface [nucleotide binding]; other site 691437007051 anticodon binding site; other site 691437007052 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 691437007053 DivIVA protein; Region: DivIVA; pfam05103 691437007054 DivIVA domain; Region: DivI1A_domain; TIGR03544 691437007055 Uncharacterized conserved protein, contains S4-like domain [Function unknown]; Region: COG2302 691437007056 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 691437007057 RNA binding surface [nucleotide binding]; other site 691437007058 YGGT family; Region: YGGT; cl00508 691437007059 Protein of unknown function (DUF552); Region: DUF552; cl00775 691437007060 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635 691437007061 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 691437007062 catalytic residue [active] 691437007063 Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496 691437007064 Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; cl00650 691437007065 Photosynthetic reaction center (RC) complex, subunit H; RC is an integral membrane protein-pigment complex which catalyzes light-induced reduction of ubiquinone to ubiquinol, generating a transmembrane electrochemical gradient of protons used to produce...; Region: PRCH; cl09959 691437007066 sporulation sigma factor SigG; Reviewed; Region: PRK08215 691437007067 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 691437007068 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 691437007069 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 691437007070 DNA binding residues [nucleotide binding] 691437007071 sporulation sigma factor SigE; Reviewed; Region: PRK08301 691437007072 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 691437007073 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 691437007074 DNA binding residues [nucleotide binding] 691437007075 Sporulation factor SpoIIGA; Region: Peptidase_U4; pfam03419 691437007076 sigma-E processing peptidase SpoIIGA; Region: spore_II_GA; TIGR02854 691437007077 cell division protein FtsZ; Validated; Region: PRK09330 691437007078 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 691437007079 nucleotide binding site [chemical binding]; other site 691437007080 SulA interaction site; other site 691437007081 cell division protein FtsA; Region: ftsA; TIGR01174 691437007082 Cell division protein FtsA; Region: FtsA; cl11496 691437007083 Cell division protein FtsA; Region: FtsA; cl11496 691437007084 Protein of unknown function (DUF1290); Region: DUF1290; cl01587 691437007085 Bacterial protein of unknown function (DUF881); Region: DUF881; pfam05949 691437007086 Bacterial protein of unknown function (DUF881); Region: DUF881; pfam05949 691437007087 Cell division septal protein [Cell envelope biogenesis, outer membrane]; Region: FtsQ; COG1589 691437007088 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 691437007089 Cell division protein FtsQ; Region: FtsQ; pfam03799 691437007090 Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511 691437007091 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK02472 691437007092 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 691437007093 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 691437007094 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 691437007095 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 691437007096 Mg++ binding site [ion binding]; other site 691437007097 putative catalytic motif [active] 691437007098 putative substrate binding site [chemical binding]; other site 691437007099 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 691437007100 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 691437007101 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 691437007102 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 691437007103 stage V sporulation protein D; Region: spoVD_pbp; TIGR02214 691437007104 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 691437007105 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 691437007106 PASTA domain. This domain is found at the C-termini of several Penicillin-binding proteins (PBPs) and bacterial serine/threonine kinases. It is a small globular fold consisting of 3 beta-sheets and an alpha-helix. The name PASTA is derived from PBP and...; Region: PASTA; cd06573 691437007107 stage V sporulation protein D; Region: spoVD_pbp; TIGR02214 691437007108 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 691437007109 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 691437007110 PASTA domain of PBP2x-like proteins, first repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_1; cd06576 691437007111 PASTA domain of PBP2x-like proteins, second repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_2; cd06575 691437007112 Septum formation initiator; Region: DivIC; cl11433 691437007113 Predicted S-adenosylmethionine-dependent methyltransferase involved in cell envelope biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG0275 691437007114 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 691437007115 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4365 691437007116 bacillithiol biosynthesis cysteine-adding enzyme BshC; Region: thiol_BshC; TIGR03998 691437007117 Protein of unknown function (DUF3397); Region: DUF3397; pfam11877 691437007118 2-dehydropantoate 2-reductase; Reviewed; Region: PRK06522 691437007119 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 691437007120 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 691437007121 transcription factor, RsfA family; Region: DNA_bind_RsfA; TIGR02894 691437007122 putative spore coat protein regulator protein YlbO; Provisional; Region: PRK13923 691437007123 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 691437007124 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 691437007125 substrate binding site [chemical binding]; other site 691437007126 oxyanion hole (OAH) forming residues; other site 691437007127 trimer interface [polypeptide binding]; other site 691437007128 Ribosomal L32p protein family; Region: Ribosomal_L32p; cl09115 691437007129 Uncharacterized ACR, COG1399; Region: DUF177; cl00616 691437007130 hypothetical protein; Provisional; Region: PRK13670 691437007131 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 691437007132 Predicted secreted protein containing a PDZ domain [Signal transduction mechanisms]; Region: SdrC; COG3480 691437007133 PDZ domain of ATP-dependent LON serine proteases. Most PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated. In this bacterial subfamily of protease-associated PDZ...; Region: PDZ_LON_protease; cd00986 691437007134 protein binding site [polypeptide binding]; other site 691437007135 Subunit ChlI of Mg-chelatase; Region: ChlI; cl12214 691437007136 Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396 691437007137 active site 691437007138 nucleophile elbow; other site 691437007139 sporulation integral membrane protein YlbJ; Region: spore_ylbJ; TIGR02871 691437007140 Nucleoside recognition; Region: Gate; cl00486 691437007141 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 691437007142 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 691437007143 active site 691437007144 (T/H)XGH motif; other site 691437007145 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 691437007146 S-adenosylmethionine binding site [chemical binding]; other site 691437007147 Uncharacterized protein conserved in bacteria (DUF2129); Region: DUF2129; cl11453 691437007148 Protein of unknown function (DUF964); Region: DUF964; cl01483 691437007149 YlbE-like protein; Region: YlbE; pfam14003 691437007150 Putative coat protein; Region: YlbD_coat; pfam14071 691437007151 Uncharacterized protein with SCP/PR1 domains [Function unknown]; Region: COG2340 691437007152 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 691437007153 FOG: CBS domain [General function prediction only]; Region: COG0517 691437007154 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_9; cd04622 691437007155 YugN-like family; Region: YugN; pfam08868 691437007156 Asp23 family; Region: Asp23; cl00574 691437007157 Protein of unknown function (DUF420); Region: DUF420; cl00989 691437007158 Cytochrome c oxidase caa3 assembly factor (Caa3_CtaG); Region: Caa3_CtaG; cl09173 691437007159 Prokaryotic Cytochrome C oxidase subunit IV; Region: COX4_pro; cl01204 691437007160 Ubiquinol oxidase subunit III subfamily. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously...; Region: Ubiquinol_oxidase_III; cd02863 691437007161 Subunit I/III interface [polypeptide binding]; other site 691437007162 Subunit III/IV interface [polypeptide binding]; other site 691437007163 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 691437007164 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 691437007165 D-pathway; other site 691437007166 Putative ubiquinol binding site [chemical binding]; other site 691437007167 Low-spin heme (heme b) binding site [chemical binding]; other site 691437007168 Putative water exit pathway; other site 691437007169 Binuclear center (heme o3/CuB) [ion binding]; other site 691437007170 K-pathway; other site 691437007171 Putative proton exit pathway; other site 691437007172 Heme/copper-type cytochrome/quinol oxidases, subunit 2 [Energy production and conversion]; Region: CyoA; COG1622 691437007173 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; cl11412 691437007174 Cytochrome c; Region: Cytochrom_C; cl11414 691437007175 UbiA prenyltransferase family; Region: UbiA; cl00337 691437007176 Cytochrome oxidase assembly protein; Region: COX15-CtaA; cl15852 691437007177 pyruvate carboxylase; Reviewed; Region: PRK12999 691437007178 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 691437007179 ATP-grasp domain; Region: ATP-grasp_4; cl03087 691437007180 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; cl08365 691437007181 Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937 691437007182 active site 691437007183 catalytic residues [active] 691437007184 metal binding site [ion binding]; metal-binding site 691437007185 homodimer binding site [polypeptide binding]; other site 691437007186 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 691437007187 carboxyltransferase (CT) interaction site; other site 691437007188 biotinylation site [posttranslational modification]; other site 691437007189 Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511 691437007190 Protein of unknown function (DUF1507); Region: DUF1507; cl11487 691437007191 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 691437007192 NYN ribonuclease and ATPase of PhoH family domains [General function prediction only]; Region: COG1875 691437007193 PIN domain of bacterial Smg6-like homologs with PhoH-like ATPase domains; Region: PIN_PhoHL-ATPase; cd09883 691437007194 putative active site [active] 691437007195 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 691437007196 sporulation lipoprotein, YhcN/YlaJ family; Region: spore_YhcN_YlaJ; TIGR02898 691437007197 Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ); Region: Spore_YhcN_YlaJ; pfam09580 691437007198 Uncharacterized protein conserved in bacteria (DUF2197); Region: DUF2197; cl11558 691437007199 YlaH-like protein; Region: YlaH; pfam14036 691437007200 Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217 691437007201 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 691437007202 G1 box; other site 691437007203 putative GEF interaction site [polypeptide binding]; other site 691437007204 GTP/Mg2+ binding site [chemical binding]; other site 691437007205 Switch I region; other site 691437007206 G2 box; other site 691437007207 G3 box; other site 691437007208 Switch II region; other site 691437007209 G4 box; other site 691437007210 G5 box; other site 691437007211 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 691437007212 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 691437007213 Inositol-monophosphatase-like domains. This family of phosphatases is dependent on bivalent metal ions such as Mg++, and many members are inhibited by Li+ (which is thought to displace a bivalent ion in the active site). Substrates include fructose-1; Region: IMPase_like; cd01637 691437007214 active site 691437007215 putative enoyl-[acyl-carrier-protein] reductase II; Region: enACPred_II; TIGR03151 691437007216 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 691437007217 FMN binding site [chemical binding]; other site 691437007218 substrate binding site [chemical binding]; other site 691437007219 putative catalytic residue [active] 691437007220 Arginine/lysine/ornithine decarboxylases [Amino acid transport and metabolism]; Region: LdcC; COG1982 691437007221 Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615 691437007222 homodimer interface [polypeptide binding]; other site 691437007223 pyridoxal 5'-phosphate binding site [chemical binding]; other site 691437007224 catalytic residue [active] 691437007225 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 691437007226 Domain of unknown function (DUF4182); Region: DUF4182; pfam13790 691437007227 Domain of unknown function (DUF1885); Region: DUF1885; pfam08968 691437007228 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06416 691437007229 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 691437007230 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 691437007231 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 691437007232 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 691437007233 E3 interaction surface; other site 691437007234 lipoyl attachment site [posttranslational modification]; other site 691437007235 e3 binding domain; Region: E3_binding; pfam02817 691437007236 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; cl02008 691437007237 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 691437007238 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 691437007239 alpha subunit interface [polypeptide binding]; other site 691437007240 TPP binding site [chemical binding]; other site 691437007241 heterodimer interface [polypeptide binding]; other site 691437007242 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 691437007243 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_x; TIGR03181 691437007244 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 691437007245 TPP-binding site [chemical binding]; other site 691437007246 tetramer interface [polypeptide binding]; other site 691437007247 heterodimer interface [polypeptide binding]; other site 691437007248 phosphorylation loop region [posttranslational modification] 691437007249 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 691437007250 active site 691437007251 catalytic residues [active] 691437007252 metal binding site [ion binding]; metal-binding site 691437007253 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 691437007254 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 691437007255 active site 691437007256 motif I; other site 691437007257 motif II; other site 691437007258 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 691437007259 motif II; other site 691437007260 Protein of unknown function (DUF1447); Region: DUF1447; cl11492 691437007261 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 691437007262 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 691437007263 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 691437007264 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 691437007265 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 691437007266 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl15357 691437007267 Uncharacterized protein family (UPF0180); Region: UPF0180; cl04214 691437007268 M20 Peptidase Aminoacyclase-1 YkuR-like proteins, including YkuR and Ama/HipO/HyuC proteins; Region: M20_Acy1_YkuR_like; cd05670 691437007269 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 691437007270 metal binding site [ion binding]; metal-binding site 691437007271 putative dimer interface [polypeptide binding]; other site 691437007272 Tetrahydrodipicolinate succinyltransferase N-terminal; Region: DapH_N; pfam08503 691437007273 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-acetyltransferase; Region: DapD_Ac; TIGR03532 691437007274 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (also called THP succinyltransferase): THDP N-succinyltransferase catalyzes the conversion of tetrahydrodipicolinate and succinyl-CoA to N-succinyltetrahydrodipicolinate and CoA; Region: LbH_THP_succinylT; cd03350 691437007275 active site 691437007276 trimer interface [polypeptide binding]; other site 691437007277 substrate binding site [chemical binding]; other site 691437007278 CoA binding site [chemical binding]; other site 691437007279 FOG: CBS domain [General function prediction only]; Region: COG0517 691437007280 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_30; cd04643 691437007281 Antirepressor AbbA; Region: AbbA_antirepres; pfam14156 691437007282 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 691437007283 EAL-domain associated signalling protein domain; Region: YkuI_C; pfam10388 691437007284 short chain dehydrogenase; Provisional; Region: PRK07677 691437007285 Trans-2-enoyl-CoA reductase (TER) and 2,4-dienoyl-CoA reductase (DECR), atypical (a) SDR; Region: TER_DECR_SDR_a; cd05369 691437007286 NAD(P) binding site [chemical binding]; other site 691437007287 substrate binding site [chemical binding]; other site 691437007288 homotetramer interface [polypeptide binding]; other site 691437007289 active site 691437007290 homodimer interface [polypeptide binding]; other site 691437007291 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 691437007292 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 691437007293 putative active site [active] 691437007294 putative metal binding site [ion binding]; other site 691437007295 YkyB-like protein; Region: YkyB; pfam14177 691437007296 Glycosyltransferases, probably involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG1215 691437007297 CESA_like is the cellulose synthase superfamily; Region: CESA_like; cd06423 691437007298 DXD motif; other site 691437007299 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 691437007300 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 691437007301 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 691437007302 active site 691437007303 phosphorylation site [posttranslational modification] 691437007304 intermolecular recognition site; other site 691437007305 dimerization interface [polypeptide binding]; other site 691437007306 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 691437007307 metal binding site [ion binding]; metal-binding site 691437007308 active site 691437007309 I-site; other site 691437007310 Response regulator receiver domain; Region: Response_reg; pfam00072 691437007311 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 691437007312 active site 691437007313 phosphorylation site [posttranslational modification] 691437007314 intermolecular recognition site; other site 691437007315 dimerization interface [polypeptide binding]; other site 691437007316 BacA is a bacterial lysin from Enterococcus faecalis that degrades bacterial cell walls by catalyzing the hydrolysis of 1,4-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues. BacA is homologous to the YbfG and YkuG lysins of...; Region: GH25_BacA-like; cd06418 691437007317 active site 691437007318 magnesium Mg(2+) and cobalt Co(2+) transport protein (corA); Region: corA; TIGR00383 691437007319 magnesium/nickel/cobalt transporter CorA; Provisional; Region: PRK11085; cl00459 691437007320 IDEAL domain; Region: IDEAL; cl07452 691437007321 aminotransferase A; Validated; Region: PRK07683 691437007322 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 691437007323 pyridoxal 5'-phosphate binding site [chemical binding]; other site 691437007324 homodimer interface [polypeptide binding]; other site 691437007325 catalytic residue [active] 691437007326 putative NAD(P)H quinone oxidoreductase, PIG3 family; Region: quinone_pig3; TIGR02824 691437007327 Quinone oxidoreductase (QOR); Region: QOR1; cd08241 691437007328 NAD(P) binding site [chemical binding]; other site 691437007329 2-phosphosulpholactate phosphatase; Region: 2-ph_phosp; cl00895 691437007330 Phosphosulfolactate phosphohydrolase and related enzymes [Coenzyme metabolism / General function prediction only]; Region: COG2045 691437007331 Predicted aminoglycoside phosphotransferase [General function prediction only]; Region: COG3173 691437007332 Acyl-CoA dehydrogenase (ACAD) 10 and 11, N-terminal domain, and similar proteins. This subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: ACAD10_11_like; cd05154 691437007333 putative active site [active] 691437007334 putative substrate binding site [chemical binding]; other site 691437007335 ATP binding site [chemical binding]; other site 691437007336 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 691437007337 Helix-turn-helix domains; Region: HTH; cl00088 691437007338 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07656 691437007339 AMP-binding enzyme; Region: AMP-binding; cl15778 691437007340 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 691437007341 gluconate 5-dehydrogenase; Provisional; Region: PRK08213 691437007342 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 691437007343 NAD(P) binding site [chemical binding]; other site 691437007344 active site 691437007345 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 691437007346 Acyl-CoA dehydrogenases similar to fadE2; Region: ACAD_FadE2; cd01155 691437007347 FAD binding site [chemical binding]; other site 691437007348 substrate binding site [chemical binding]; other site 691437007349 catalytic base [active] 691437007350 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 691437007351 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 691437007352 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 691437007353 putative beta-ketoacyl acyl carrier protein [ACP] reductase (BKR)-like, SDR; Region: BKR_like_SDR_like; cd05344 691437007354 putative NAD(P) binding site [chemical binding]; other site 691437007355 putative active site [active] 691437007356 dihydrolipoamide succinyltransferase; Validated; Region: PRK05704 691437007357 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 691437007358 E3 interaction surface; other site 691437007359 lipoyl attachment site [posttranslational modification]; other site 691437007360 e3 binding domain; Region: E3_binding; pfam02817 691437007361 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; cl02008 691437007362 2-oxoglutarate dehydrogenase E1 component; Reviewed; Region: sucA; PRK09404 691437007363 Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016 691437007364 TPP-binding site [chemical binding]; other site 691437007365 Pyrimidine (PYR) binding domain of thiamine pyrophosphate (TPP)-dependent enzymes; Region: TPP_enzyme_PYR; cl11410 691437007366 Cache domain; Region: Cache_1; pfam02743 691437007367 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 691437007368 dimerization interface [polypeptide binding]; other site 691437007369 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 691437007370 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 691437007371 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 691437007372 dimer interface [polypeptide binding]; other site 691437007373 putative CheW interface [polypeptide binding]; other site 691437007374 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 691437007375 Putative peptidoglycan binding domain; Region: PG_binding_1; cl15437 691437007376 Protein of unknown function (DUF1256); Region: DUF1256; cl06087 691437007377 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 691437007378 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 691437007379 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; cl01586 691437007380 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl09155 691437007381 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 691437007382 dimerization domain swap beta strand [polypeptide binding]; other site 691437007383 regulatory protein interface [polypeptide binding]; other site 691437007384 active site 691437007385 regulatory phosphorylation site [posttranslational modification]; other site 691437007386 PTS system, glucose-specific IIBC component; Region: PTS-II-BC-glcB; TIGR02002 691437007387 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; cl00557 691437007388 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 691437007389 active site turn [active] 691437007390 phosphorylation site [posttranslational modification] 691437007391 Biotin carboxyl carrier protein [Lipid metabolism]; Region: AccB; COG0511 691437007392 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210 691437007393 HPr interaction site; other site 691437007394 glycerol kinase (GK) interaction site [polypeptide binding]; other site 691437007395 active site 691437007396 phosphorylation site [posttranslational modification] 691437007397 transcriptional antiterminator BglG; Provisional; Region: PRK09772 691437007398 CAT RNA binding domain; Region: CAT_RBD; cl03904 691437007399 PRD domain; Region: PRD; cl15445 691437007400 PRD domain; Region: PRD; cl15445 691437007401 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 691437007402 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 691437007403 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 691437007404 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 691437007405 putative active site [active] 691437007406 heme pocket [chemical binding]; other site 691437007407 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 691437007408 dimer interface [polypeptide binding]; other site 691437007409 phosphorylation site [posttranslational modification] 691437007410 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 691437007411 ATP binding site [chemical binding]; other site 691437007412 Mg2+ binding site [ion binding]; other site 691437007413 G-X-G motif; other site 691437007414 YueH-like protein; Region: YueH; pfam14166 691437007415 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 691437007416 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 691437007417 NAD(P) binding site [chemical binding]; other site 691437007418 active site 691437007419 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118 691437007420 putative peptidoglycan binding site; other site 691437007421 Cell Wall Hydrolase; Region: Hydrolase_2; pfam07486 691437007422 Uncharacterized protein conserved in bacteria (DUF2187); Region: DUF2187; cl11556 691437007423 CC3(TIP30)-like, atypical (a) SDRs; Region: CC3_like_SDR_a; cd05250 691437007424 NAD binding site [chemical binding]; other site 691437007425 active site 691437007426 Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1), 6-pyrovoyl...; Region: TFold; cl00263 691437007427 7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE; Region: Bsubt_queE; TIGR03365 691437007428 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cl15377 691437007429 FeS/SAM binding site; other site 691437007430 Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1), 6-pyrovoyl...; Region: TFold; cl00263 691437007431 active site 691437007432 ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995 691437007433 Ligand Binding Site [chemical binding]; other site 691437007434 Spore germination protein; Region: Spore_permease; cl15802 691437007435 Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; cl05194 691437007436 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 691437007437 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 691437007438 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 691437007439 dimer interface [polypeptide binding]; other site 691437007440 putative CheW interface [polypeptide binding]; other site 691437007441 Uncharacterized membrane protein [Function unknown]; Region: COG3949 691437007442 FixH; Region: FixH; cl01254 691437007443 FixH; Region: FixH; cl01254 691437007444 Modulator of heat shock repressor CtsR, McsA [Signal transduction mechanisms]; Region: COG3880 691437007445 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 691437007446 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 691437007447 Walker A motif; other site 691437007448 ATP binding site [chemical binding]; other site 691437007449 Walker B motif; other site 691437007450 arginine finger; other site 691437007451 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 691437007452 Walker A motif; other site 691437007453 ATP binding site [chemical binding]; other site 691437007454 Walker B motif; other site 691437007455 arginine finger; other site 691437007456 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; cl11083 691437007457 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 691437007458 active site 691437007459 NTP binding site [chemical binding]; other site 691437007460 metal binding triad [ion binding]; metal-binding site 691437007461 antibiotic binding site [chemical binding]; other site 691437007462 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 691437007463 Helix-turn-helix domains; Region: HTH; cl00088 691437007464 ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668 691437007465 ABC-2 type transporter; Region: ABC2_membrane; cl11417 691437007466 ABC transporter, ATP-binding subunit, PQQ-dependent alcohol dehydrogenase system; Region: PQQ_ABC_ATP; TIGR03864 691437007467 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 691437007468 Walker A/P-loop; other site 691437007469 ATP binding site [chemical binding]; other site 691437007470 Q-loop/lid; other site 691437007471 ABC transporter signature motif; other site 691437007472 Walker B; other site 691437007473 D-loop; other site 691437007474 H-loop/switch region; other site 691437007475 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 691437007476 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 691437007477 Coenzyme A binding pocket [chemical binding]; other site 691437007478 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_1; cd09606 691437007479 oligoendopeptidase, M3 family; Region: M3_not_pepF; TIGR02289 691437007480 active site 691437007481 Zn binding site [ion binding]; other site 691437007482 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506 691437007483 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 691437007484 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 691437007485 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 691437007486 short chain dehydrogenase; Provisional; Region: PRK08309 691437007487 Propanediol utilisation protein PduL; Region: PduL; pfam06130 691437007488 Propanediol utilisation protein PduL; Region: PduL; pfam06130 691437007489 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 691437007490 Helix-turn-helix domains; Region: HTH; cl00088 691437007491 Predicted divalent heavy-metal cations transporter [Inorganic ion transport and metabolism]; Region: COG0428; cl00437 691437007492 Domain of unknown function (DUF3418); Region: DUF3418; pfam11898 691437007493 Cupin domain; Region: Cupin_2; cl09118 691437007494 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cl00214 691437007495 intersubunit interface [polypeptide binding]; other site 691437007496 active site 691437007497 Zn2+ binding site [ion binding]; other site 691437007498 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 691437007499 haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702 691437007500 2,3-diketo-5-methylthiopentyl-1-phosphate enolase; Reviewed; Region: mtnW; PRK09549 691437007501 2,3-diketo-5-methylthiopentyl-1-phosphate enolase; Region: RLP_DK-MTP-1-P-enolase; cd08209 691437007502 dimer interface [polypeptide binding]; other site 691437007503 active site 691437007504 catalytic residue [active] 691437007505 metal binding site [ion binding]; metal-binding site 691437007506 transaminase; Reviewed; Region: PRK08068 691437007507 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 691437007508 pyridoxal 5'-phosphate binding site [chemical binding]; other site 691437007509 homodimer interface [polypeptide binding]; other site 691437007510 catalytic residue [active] 691437007511 Predicted amidohydrolase [General function prediction only]; Region: COG0388 691437007512 Uncharacterized subgroup of the nitrilase superfamily (putative class 13 nitrilases); Region: nitrilase_5; cd07583 691437007513 putative active site [active] 691437007514 catalytic triad [active] 691437007515 putative dimer interface [polypeptide binding]; other site 691437007516 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 691437007517 methylthioribose-1-phosphate isomerase; Reviewed; Region: mtnA; PRK05720 691437007518 Predicted translation initiation factor 2B subunit, eIF-2B alpha/beta/delta family [Translation, ribosomal structure and biogenesis]; Region: COG0182; cl00348 691437007519 Methylthioribose-binding protein-like of ABC-type transport systems that belong to a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_methylthioribose_binding_like; cd06305 691437007520 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 691437007521 putative ligand binding site [chemical binding]; other site 691437007522 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 691437007523 This family represents the domain I of the carbohydrate uptake proteins that transport only monosaccharides (Monos). The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and hexoses...; Region: ABC_Carb_Monos_I; cd03216 691437007524 Walker A/P-loop; other site 691437007525 ATP binding site [chemical binding]; other site 691437007526 Q-loop/lid; other site 691437007527 ABC transporter signature motif; other site 691437007528 Walker B; other site 691437007529 D-loop; other site 691437007530 H-loop/switch region; other site 691437007531 This family represents domain II of the carbohydrate uptake proteins that transport only monosaccharides (Monos). The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and hexoses; Region: ABC_Carb_Monos_II; cd03215 691437007532 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 691437007533 TM-ABC transporter signature motif; other site 691437007534 methylated-DNA--protein-cysteine methyltransferase; Provisional; Region: PRK00901 691437007535 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 691437007536 DNA binding site [nucleotide binding] 691437007537 active site 691437007538 PAS domain S-box; Region: sensory_box; TIGR00229 691437007539 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 691437007540 PAS domain S-box; Region: sensory_box; TIGR00229 691437007541 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 691437007542 PAS domain S-box; Region: sensory_box; TIGR00229 691437007543 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 691437007544 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 691437007545 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 691437007546 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 691437007547 dimer interface [polypeptide binding]; other site 691437007548 phosphorylation site [posttranslational modification] 691437007549 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 691437007550 ATP binding site [chemical binding]; other site 691437007551 Mg2+ binding site [ion binding]; other site 691437007552 G-X-G motif; other site 691437007553 B12 binding domain_like associated with radical SAM domain. This domain shows similarity with B12 (adenosylcobamide) binding domains found in several enzymes, such as glutamate mutase, methionine synthase and methylmalonyl-CoA mutase, but it lacks the...; Region: radical_SAM_B12_BD; cd02068 691437007554 Radical SAM superfamily; Region: Radical_SAM; pfam04055 691437007555 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 691437007556 FeS/SAM binding site; other site 691437007557 Protein of unknown function (DUF4080); Region: DUF4080; pfam13311 691437007558 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 691437007559 Major Facilitator Superfamily; Region: MFS_1; pfam07690 691437007560 putative substrate translocation pore; other site 691437007561 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 691437007562 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 691437007563 dimer interface [polypeptide binding]; other site 691437007564 conserved gate region; other site 691437007565 putative PBP binding loops; other site 691437007566 ABC-ATPase subunit interface; other site 691437007567 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 691437007568 dimer interface [polypeptide binding]; other site 691437007569 conserved gate region; other site 691437007570 putative PBP binding loops; other site 691437007571 ABC-ATPase subunit interface; other site 691437007572 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 691437007573 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 691437007574 Glycogen debranching enzyme [Carbohydrate transport and metabolism]; Region: GDB1; COG3408 691437007575 Bacterial alpha-L-rhamnosidase; Region: Bac_rhamnosid; cl01801 691437007576 Transcriptional regulators [Transcription]; Region: PurR; COG1609 691437007577 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 691437007578 DNA binding site [nucleotide binding] 691437007579 domain linker motif; other site 691437007580 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 691437007581 dimerization interface [polypeptide binding]; other site 691437007582 ligand binding site [chemical binding]; other site 691437007583 Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269 691437007584 amino acid transporter; Region: 2A0306; TIGR00909 691437007585 Spore germination protein; Region: Spore_permease; cl15802 691437007586 Spore germination protein; Region: Spore_permease; cl15802 691437007587 Protein of unknown function, DUF485; Region: DUF485; cl01231 691437007588 Sodium:solute symporter family; Region: SSF; cl00456 691437007589 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 691437007590 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 691437007591 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 691437007592 Coenzyme A binding pocket [chemical binding]; other site 691437007593 N-acylamino acid racemase (NAAAR), an octameric enzyme that catalyzes the racemization of N-acylamino acids. NAAARs act on a broad range of N-acylamino acids rather than amino acids. Enantiopure amino acids are of industrial interest as chiral building...; Region: NAAAR; cd03317 691437007594 o-succinylbenzoate synthase; Region: menC_lowGC/arch; TIGR01928 691437007595 active site 691437007596 octamer interface [polypeptide binding]; other site 691437007597 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 691437007598 Coenzyme A binding pocket [chemical binding]; other site 691437007599 M20 Peptidase Aminoacylase 1 amhX_like subfamily; Region: M20_Acy1_amhX_like; cd08018 691437007600 amidohydrolase; Region: amidohydrolases; TIGR01891 691437007601 metal binding site [ion binding]; metal-binding site 691437007602 putative dimer interface [polypeptide binding]; other site 691437007603 Protein of unknown function (DUF1212); Region: DUF1212; cl01118 691437007604 Uncharacterized conserved protein [Function unknown]; Region: COG2966 691437007605 Protein of unknown function (DUF1212); Region: DUF1212; cl01118 691437007606 Protein of unknown function (DUF1212); Region: DUF1212; cl01118 691437007607 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 691437007608 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; cl01255 691437007609 Diacylglycerol kinase accessory domain; Region: DAGK_acc; cl02440 691437007610 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13905 691437007611 FAD binding domain; Region: FAD_binding_4; pfam01565 691437007612 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 691437007613 Encapsulating protein for peroxidase; Region: Linocin_M18; cl12047 691437007614 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 691437007615 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 691437007616 putative active site pocket [active] 691437007617 dimerization interface [polypeptide binding]; other site 691437007618 putative catalytic residue [active] 691437007619 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 691437007620 putative active site pocket [active] 691437007621 dimerization interface [polypeptide binding]; other site 691437007622 putative catalytic residue [active] 691437007623 TPR repeat; Region: TPR_11; pfam13414 691437007624 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 691437007625 TPR motif; other site 691437007626 Tetratricopeptide repeat; Region: TPR_16; pfam13432 691437007627 binding surface 691437007628 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 691437007629 dimer interface [polypeptide binding]; other site 691437007630 putative radical transfer pathway; other site 691437007631 diiron center [ion binding]; other site 691437007632 tyrosyl radical; other site 691437007633 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK09209 691437007634 Class I ribonucleotide reductase; Region: RNR_I; cd01679 691437007635 active site 691437007636 dimer interface [polypeptide binding]; other site 691437007637 catalytic residues [active] 691437007638 effector binding site; other site 691437007639 R2 peptide binding site; other site 691437007640 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 691437007641 daunorubicin resistance ABC transporter ATP-binding subunit; Region: drrA; TIGR01188 691437007642 Walker A/P-loop; other site 691437007643 ATP binding site [chemical binding]; other site 691437007644 Q-loop/lid; other site 691437007645 ABC transporter signature motif; other site 691437007646 Walker B; other site 691437007647 D-loop; other site 691437007648 H-loop/switch region; other site 691437007649 Domain of unknown function (DUF4162); Region: DUF4162; pfam13732 691437007650 ABC-2 type transporter; Region: ABC2_membrane; cl11417 691437007651 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 691437007652 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 691437007653 active site 691437007654 phosphorylation site [posttranslational modification] 691437007655 intermolecular recognition site; other site 691437007656 dimerization interface [polypeptide binding]; other site 691437007657 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 691437007658 DNA binding site [nucleotide binding] 691437007659 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 691437007660 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 691437007661 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 691437007662 dimer interface [polypeptide binding]; other site 691437007663 phosphorylation site [posttranslational modification] 691437007664 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 691437007665 ATP binding site [chemical binding]; other site 691437007666 Mg2+ binding site [ion binding]; other site 691437007667 G-X-G motif; other site 691437007668 Asparagine synthase (glutamine-hydrolyzing) [Amino acid transport and metabolism]; Region: AsnB; COG0367 691437007669 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 691437007670 active site 691437007671 dimer interface [polypeptide binding]; other site 691437007672 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 691437007673 Ligand Binding Site [chemical binding]; other site 691437007674 Molecular Tunnel; other site 691437007675 Peptidase_C39 like family; Region: Peptidase_C39_2; pfam13529 691437007676 A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the 'double-glycine' leader peptides from the precursors of various bacteriocins; Region: Peptidase_C39A; cd02549 691437007677 putative active site [active] 691437007678 Putative multicopper oxidases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: SufI; COG2132 691437007679 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; cl11412 691437007680 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; cl11412 691437007681 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; cl11412 691437007682 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 691437007683 active site 691437007684 NTP binding site [chemical binding]; other site 691437007685 metal binding triad [ion binding]; metal-binding site 691437007686 antibiotic binding site [chemical binding]; other site 691437007687 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 691437007688 metal-binding site [ion binding] 691437007689 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 691437007690 metal-binding site [ion binding] 691437007691 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 691437007692 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 691437007693 metal-binding site [ion binding] 691437007694 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 691437007695 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 691437007696 motif II; other site 691437007697 Transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this domain superfamily was previously known as DUF156; Region: CsoR-like_DUF156; cl00846 691437007698 putative homodimer interface [polypeptide binding]; other site 691437007699 putative homotetramer interface [polypeptide binding]; other site 691437007700 putative allosteric switch controlling residues; other site 691437007701 putative metal binding site [ion binding]; other site 691437007702 putative homodimer-homodimer interface [polypeptide binding]; other site 691437007703 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; cl11412 691437007704 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; cl11412 691437007705 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 691437007706 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 691437007707 Domain of unknown function (DUF4405); Region: DUF4405; pfam14358 691437007708 LysR transcriptional regulator; Provisional; Region: rbcR; CHL00180 691437007709 Helix-turn-helix domains; Region: HTH; cl00088 691437007710 C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420 691437007711 putative dimerization interface [polypeptide binding]; other site 691437007712 Conserved hypothetical protein 698; Region: Cons_hypoth698; cl01075 691437007713 integrating conjugative element protein, PFL_4705 family; Region: conj_TIGR03752 691437007714 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 691437007715 dimerization interface [polypeptide binding]; other site 691437007716 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 691437007717 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 691437007718 dimer interface [polypeptide binding]; other site 691437007719 putative CheW interface [polypeptide binding]; other site 691437007720 Predicted restriction endonuclease [Defense mechanisms]; Region: COG3183 691437007721 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cl00083 691437007722 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 691437007723 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 691437007724 HsdM N-terminal domain; Region: HsdM_N; pfam12161 691437007725 N-6 DNA Methylase; Region: N6_Mtase; pfam02384 691437007726 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 691437007727 type I restriction enzyme EcoKI subunit R; Provisional; Region: hsdR; PRK11448 691437007728 Domain of unknown function (DUF4145); Region: DUF4145; pfam13643 691437007729 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 691437007730 ATP binding site [chemical binding]; other site 691437007731 putative Mg++ binding site [ion binding]; other site 691437007732 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 691437007733 active site 691437007734 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 691437007735 Zn2+ binding site [ion binding]; other site 691437007736 Mg2+ binding site [ion binding]; other site 691437007737 cystathionine beta-lyase; Provisional; Region: PRK08064 691437007738 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 691437007739 homodimer interface [polypeptide binding]; other site 691437007740 substrate-cofactor binding pocket; other site 691437007741 pyridoxal 5'-phosphate binding site [chemical binding]; other site 691437007742 catalytic residue [active] 691437007743 cystathionine gamma-synthase; Reviewed; Region: PRK08247 691437007744 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 691437007745 homodimer interface [polypeptide binding]; other site 691437007746 substrate-cofactor binding pocket; other site 691437007747 pyridoxal 5'-phosphate binding site [chemical binding]; other site 691437007748 catalytic residue [active] 691437007749 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 691437007750 Putative esterase; Region: Esterase; pfam00756 691437007751 hypothetical protein; Provisional; Region: PRK13679 691437007752 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 691437007753 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 691437007754 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 691437007755 Coenzyme A binding pocket [chemical binding]; other site 691437007756 Stage VI sporulation protein F; Region: SpoVIF; pfam14069 691437007757 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 691437007758 catalytic residues [active] 691437007759 Protein of unknown function (DUF421); Region: DUF421; cl00990 691437007760 Protein of unknown function (DUF1657); Region: DUF1657; pfam07870 691437007761 Protein of unknown function (DUF1657); Region: DUF1657; pfam07870 691437007762 SpoVA protein; Region: SpoVA; cl04298 691437007763 stage V sporulation protein AD; Provisional; Region: PRK12404 691437007764 Stage V sporulation protein AD (SpoVAD); Region: SpoVAD; pfam07451 691437007765 SpoVA protein; Region: SpoVA; cl04298 691437007766 Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ); Region: Spore_YhcN_YlaJ; pfam09580 691437007767 Protein of unknown function (DUF1657); Region: DUF1657; pfam07870 691437007768 Bacteriophage holin; Region: Phage_holin_1; cl02344 691437007769 putative spore coat protein regulator protein YlbO; Provisional; Region: PRK13923 691437007770 Protein of unknown function (DUF1360); Region: DUF1360; pfam07098 691437007771 spore coat protein, CotS family; Region: spore_CotS; TIGR02906 691437007772 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: APH_ChoK_like; cd05120 691437007773 active site 691437007774 ATP binding site [chemical binding]; other site 691437007775 substrate binding site [chemical binding]; other site 691437007776 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 691437007777 This is a family of GT1 glycosyltransferases found specifically in certain bacteria. amsK in Erwinia amylovora, has been reported to be involved in the biosynthesis of amylovoran, a exopolysaccharide acting as a virulence factor; Region: GT1_amsK_like; cd03799 691437007778 putative ADP-binding pocket [chemical binding]; other site 691437007779 Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004 691437007780 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 691437007781 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 691437007782 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 691437007783 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 691437007784 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 691437007785 NAD(P) binding site [chemical binding]; other site 691437007786 active site 691437007787 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 691437007788 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 691437007789 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 691437007790 spore coat protein, CotS family; Region: spore_CotS; TIGR02906 691437007791 active site 691437007792 substrate binding site [chemical binding]; other site 691437007793 ATP binding site [chemical binding]; other site 691437007794 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 691437007795 lipopolysaccharide 1,2-N-acetylglucosaminetransferase; Provisional; Region: PRK15484 691437007796 Spore coat protein CotO; Region: Spore_coat_CotO; pfam14153 691437007797 Spore coat protein CotO; Region: Spore_coat_CotO; pfam14153 691437007798 Enoyl-[acyl-carrier-protein]; Region: FabI; COG0623 691437007799 Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372 691437007800 NAD binding site [chemical binding]; other site 691437007801 homotetramer interface [polypeptide binding]; other site 691437007802 homodimer interface [polypeptide binding]; other site 691437007803 substrate binding site [chemical binding]; other site 691437007804 active site 691437007805 Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511 691437007806 bis(5'-nucleosyl)-tetraphosphatase PrpE; Provisional; Region: PRK13625 691437007807 Bacillus subtilis PrpE and related proteins, metallophosphatase domain; Region: MPP_PrpE; cd07423 691437007808 active site 691437007809 metal binding site [ion binding]; metal-binding site 691437007810 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 691437007811 PseudoU_synth_RsuA/RluD: Pseudouridine synthase, RsuA/RluD family. This group is comprised of eukaryotic, bacterial and archeal proteins similar to eight site specific Escherichia coli pseudouridine synthases: RsuA, RluA, RluB, RluC, RluD, RluE, RluF and...; Region: PseudoU_synth_RluCD_like; cd02869 691437007812 active site 691437007813 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; cl01255 691437007814 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 691437007815 synthetase active site [active] 691437007816 NTP binding site [chemical binding]; other site 691437007817 metal binding site [ion binding]; metal-binding site 691437007818 Uncharacterized subgroup 1 of the CYTH-like superfamily; Region: CYTH-like_Pase_1; cd07762 691437007819 putative active site [active] 691437007820 putative metal binding residues [ion binding]; other site 691437007821 signature motif; other site 691437007822 putative triphosphate binding site [ion binding]; other site 691437007823 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic 'goose-type' lysozymes (GEWL). LTs catalyze...; Region: LT_GEWL; cd00254 691437007824 N-acetyl-D-glucosamine binding site [chemical binding]; other site 691437007825 catalytic residue [active] 691437007826 Truncated hemoglobins (trHbs) are a family of oxygen-binding heme proteins found in cyanobacteria, eubacteria, unicellular eukaryotes, and plants. The truncated hemoglobins have a characteristic two-over-two alpha helical folding pattern that is distinct...; Region: Trunc_globin; cd00454 691437007827 apolar tunnel; other site 691437007828 heme binding site [chemical binding]; other site 691437007829 dimerization interface [polypeptide binding]; other site 691437007830 DsbA family, FrnE-like subfamily; composed of uncharacterized proteins containing a CXXC motif with similarity to DsbA and FrnE. FrnE is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the...; Region: DsbA_FrnE_like; cd03025 691437007831 Thioredoxin; Region: Thioredoxin_5; pfam13743 691437007832 catalytic residues [active] 691437007833 oligoendopeptidase F; Region: pepF; TIGR00181 691437007834 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_3; cd09608 691437007835 active site 691437007836 Zn binding site [ion binding]; other site 691437007837 Competence protein CoiA-like family; Region: CoiA; cl11541 691437007838 cardiolipin synthetase; Reviewed; Region: cls; PRK01642 691437007839 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 691437007840 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 691437007841 putative active site [active] 691437007842 catalytic site [active] 691437007843 catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112 691437007844 putative active site [active] 691437007845 catalytic site [active] 691437007846 Negative regulator of genetic competence (MecA); Region: MecA; cl02022 691437007847 Integral membrane protein TerC family; Region: TerC; cl10468 691437007848 Arsenate Reductase (ArsC) family, Spx subfamily; Spx is a unique RNA polymerase (RNAP)-binding protein present in bacilli and some mollicutes. It inhibits transcription by binding to the C-terminal domain of the alpha subunit of RNAP, disrupting complex...; Region: ArsC_Spx; cd03032 691437007849 ArsC family; Region: ArsC; pfam03960 691437007850 putative catalytic residues [active] 691437007851 thiol/disulfide switch; other site 691437007852 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 691437007853 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 691437007854 Walker A/P-loop; other site 691437007855 ATP binding site [chemical binding]; other site 691437007856 Q-loop/lid; other site 691437007857 ABC transporter signature motif; other site 691437007858 Walker B; other site 691437007859 D-loop; other site 691437007860 H-loop/switch region; other site 691437007861 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 691437007862 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 691437007863 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 691437007864 Walker A/P-loop; other site 691437007865 ATP binding site [chemical binding]; other site 691437007866 Q-loop/lid; other site 691437007867 ABC transporter signature motif; other site 691437007868 Walker B; other site 691437007869 D-loop; other site 691437007870 H-loop/switch region; other site 691437007871 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 691437007872 oligopeptide ABC transporter permease OppC; Provisional; Region: PRK15406 691437007873 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 691437007874 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 691437007875 dimer interface [polypeptide binding]; other site 691437007876 conserved gate region; other site 691437007877 putative PBP binding loops; other site 691437007878 ABC-ATPase subunit interface; other site 691437007879 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 691437007880 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 691437007881 dimer interface [polypeptide binding]; other site 691437007882 conserved gate region; other site 691437007883 putative PBP binding loops; other site 691437007884 ABC-ATPase subunit interface; other site 691437007885 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 691437007886 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 691437007887 peptide binding site [polypeptide binding]; other site 691437007888 Domain of unknown function (DUF3899); Region: DUF3899; pfam13038 691437007889 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 691437007890 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 691437007891 active site 691437007892 HIGH motif; other site 691437007893 dimer interface [polypeptide binding]; other site 691437007894 KMSKS motif; other site 691437007895 Protein of unknown function (DUF3603); Region: DUF3603; pfam12227 691437007896 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 691437007897 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 691437007898 dimer interface [polypeptide binding]; other site 691437007899 active site 691437007900 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 691437007901 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 691437007902 dimer interface [polypeptide binding]; other site 691437007903 active site 691437007904 CoA binding pocket [chemical binding]; other site 691437007905 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 691437007906 Protein of unknown function (DUF2929); Region: DUF2929; pfam11151 691437007907 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 691437007908 Clp amino terminal domain; Region: Clp_N; pfam02861 691437007909 Clp amino terminal domain; Region: Clp_N; pfam02861 691437007910 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 691437007911 Walker A motif; other site 691437007912 ATP binding site [chemical binding]; other site 691437007913 Walker B motif; other site 691437007914 arginine finger; other site 691437007915 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 691437007916 Walker A motif; other site 691437007917 ATP binding site [chemical binding]; other site 691437007918 Walker B motif; other site 691437007919 arginine finger; other site 691437007920 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; cl11083 691437007921 YjzC-like protein; Region: YjzC; pfam14168 691437007922 ornithine carbamoyltransferase; Provisional; Region: PRK00779 691437007923 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 691437007924 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 691437007925 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK12815 691437007926 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 691437007927 ATP-grasp domain; Region: ATP-grasp_4; cl03087 691437007928 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 691437007929 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 691437007930 ATP-grasp domain; Region: ATP-grasp_4; cl03087 691437007931 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12838 691437007932 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; cl03056 691437007933 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 691437007934 catalytic site [active] 691437007935 subunit interface [polypeptide binding]; other site 691437007936 acetylornithine aminotransferase; Provisional; Region: argD; PRK02936 691437007937 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 691437007938 inhibitor-cofactor binding pocket; inhibition site 691437007939 pyridoxal 5'-phosphate binding site [chemical binding]; other site 691437007940 catalytic residue [active] 691437007941 AAK_NAGK-like: N-Acetyl-L-glutamate kinase (NAGK)-like . Included in this CD are the Escherichia coli and Pseudomonas aeruginosa type NAGKs which catalyze the phosphorylation of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine...; Region: AAK_NAGK-like; cd04238 691437007942 nucleotide binding site [chemical binding]; other site 691437007943 N-acetyl-L-glutamate binding site [chemical binding]; other site 691437007944 Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152 691437007945 heterotetramer interface [polypeptide binding]; other site 691437007946 active site pocket [active] 691437007947 cleavage site 691437007948 N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436 691437007949 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 691437007950 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; cl15856 691437007951 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 691437007952 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 691437007953 ligand binding site [chemical binding]; other site 691437007954 flexible hinge region; other site 691437007955 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 691437007956 putative switch regulator; other site 691437007957 non-specific DNA interactions [nucleotide binding]; other site 691437007958 DNA binding site [nucleotide binding] 691437007959 sequence specific DNA binding site [nucleotide binding]; other site 691437007960 putative cAMP binding site [chemical binding]; other site 691437007961 YwiC-like protein; Region: YwiC; pfam14256 691437007962 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 691437007963 MoaE interaction surface [polypeptide binding]; other site 691437007964 MoeB interaction surface [polypeptide binding]; other site 691437007965 thiocarboxylated glycine; other site 691437007966 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 691437007967 MoaE homodimer interface [polypeptide binding]; other site 691437007968 MoaD interaction [polypeptide binding]; other site 691437007969 active site residues [active] 691437007970 Molybdenum is an essential trace element in the form of molybdenum cofactor (Moco) which is associated with the metabolism of nitrogen, carbon and sulfur by redox active enzymes. In E. coli, the synthesis of Moco involves genes from several loci: moa; Region: MobB; cd03116 691437007971 Walker A motif; other site 691437007972 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 691437007973 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 691437007974 dimer interface [polypeptide binding]; other site 691437007975 putative functional site; other site 691437007976 putative MPT binding site; other site 691437007977 iron-sulfur cluster repair di-iron protein; Region: FeS_repair_RIC; TIGR03652 691437007978 Domain of unknown function (DUF1858); Region: DUF1858; cl14817 691437007979 Hemerythrin (Hr) is a non-heme diiron oxygen transport protein found in four marine invertebrate phyla including priapulida, brachiopoda, sipunculida, and annelida, as well as in protozoa. Myohemerythrin (Mhr), a hemerythrin homolog, is found in the...; Region: Hemerythrin; cl15774 691437007980 molybdenum cofactor biosynthesis protein A, bacterial; Region: moaA; TIGR02666 691437007981 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 691437007982 FeS/SAM binding site; other site 691437007983 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 691437007984 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 691437007985 putative PBP binding loops; other site 691437007986 dimer interface [polypeptide binding]; other site 691437007987 ABC-ATPase subunit interface; other site 691437007988 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 691437007989 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 691437007990 ligand binding site [chemical binding]; other site 691437007991 flexible hinge region; other site 691437007992 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 691437007993 putative switch regulator; other site 691437007994 non-specific DNA interactions [nucleotide binding]; other site 691437007995 DNA binding site [nucleotide binding] 691437007996 sequence specific DNA binding site [nucleotide binding]; other site 691437007997 putative cAMP binding site [chemical binding]; other site 691437007998 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; cl11412 691437007999 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 691437008000 nitrite extrusion protein (nitrite facilitator); Region: 2A0108; TIGR00886 691437008001 putative substrate translocation pore; other site 691437008002 ABC-2 type transporter; Region: ABC2_membrane; cl11417 691437008003 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 691437008004 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 691437008005 Walker A/P-loop; other site 691437008006 ATP binding site [chemical binding]; other site 691437008007 Q-loop/lid; other site 691437008008 ABC transporter signature motif; other site 691437008009 Walker B; other site 691437008010 D-loop; other site 691437008011 H-loop/switch region; other site 691437008012 Predicted membrane protein [Function unknown]; Region: COG1470 691437008013 Ubp3 associated protein Bre5; Region: Bre5; pfam11614 691437008014 NPCBM-associated, NEW3 domain of alpha-galactosidase; Region: NPCBM_assoc; pfam10633 691437008015 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 691437008016 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 691437008017 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 691437008018 DNA binding residues [nucleotide binding] 691437008019 Anti-sigma-K factor rskA; Region: RskA; pfam10099 691437008020 radical SAM protein, BA_1875 family; Region: sam_11; TIGR04053 691437008021 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 691437008022 FeS/SAM binding site; other site 691437008023 Domain of unknown function (DUF4008); Region: DUF4008; cl14869 691437008024 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 691437008025 putative bacteriocin export ABC transporter, lactococcin 972 group; Region: L_ocin_972_ABC; TIGR03608 691437008026 Walker A/P-loop; other site 691437008027 ATP binding site [chemical binding]; other site 691437008028 Q-loop/lid; other site 691437008029 ABC transporter signature motif; other site 691437008030 Walker B; other site 691437008031 D-loop; other site 691437008032 H-loop/switch region; other site 691437008033 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 691437008034 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 691437008035 Walker A/P-loop; other site 691437008036 ATP binding site [chemical binding]; other site 691437008037 Q-loop/lid; other site 691437008038 ABC transporter signature motif; other site 691437008039 Walker B; other site 691437008040 D-loop; other site 691437008041 H-loop/switch region; other site 691437008042 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 691437008043 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 691437008044 active site 691437008045 phosphorylation site [posttranslational modification] 691437008046 intermolecular recognition site; other site 691437008047 dimerization interface [polypeptide binding]; other site 691437008048 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 691437008049 DNA binding residues [nucleotide binding] 691437008050 dimerization interface [polypeptide binding]; other site 691437008051 MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503 691437008052 molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317 691437008053 GTP binding site; other site 691437008054 SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain. SirA (also known as UvrY, and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cl00436 691437008055 MAEBL; Provisional; Region: PTZ00121 691437008056 Nitric oxide reductase large subunit [Inorganic ion transport and metabolism]; Region: NorB; COG3256 691437008057 Gluconate 2-dehydrogenase subunit 3; Region: Gluconate_2-dh3; pfam13618 691437008058 Heme-copper oxidase subunit I. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which catalyze the reduction of O2 and simultaneously pump protons across the membrane. The superfamily is...; Region: Heme_Cu_Oxidase_I; cl00275 691437008059 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 691437008060 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 691437008061 ligand binding site [chemical binding]; other site 691437008062 flexible hinge region; other site 691437008063 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 691437008064 putative switch regulator; other site 691437008065 non-specific DNA interactions [nucleotide binding]; other site 691437008066 DNA binding site [nucleotide binding] 691437008067 sequence specific DNA binding site [nucleotide binding]; other site 691437008068 putative cAMP binding site [chemical binding]; other site 691437008069 SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain. SirA (also known as UvrY, and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cl00436 691437008070 SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain. SirA (also known as UvrY, and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291 691437008071 CPxP motif; other site 691437008072 Domain of unknown function DUF59; Region: DUF59; cl00941 691437008073 Fic family protein [Function unknown]; Region: COG3177 691437008074 Fic/DOC family; Region: Fic; cl00960 691437008075 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 691437008076 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 691437008077 metal-binding site [ion binding] 691437008078 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 691437008079 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 691437008080 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 691437008081 dimerization interface [polypeptide binding]; other site 691437008082 putative DNA binding site [nucleotide binding]; other site 691437008083 putative Zn2+ binding site [ion binding]; other site 691437008084 esterase; Provisional; Region: PRK10566 691437008085 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 691437008086 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 691437008087 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 691437008088 active site 691437008089 motif I; other site 691437008090 motif II; other site 691437008091 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 691437008092 Protein of unknown function (DUF3813); Region: DUF3813; pfam12758 691437008093 Uncharacterized protein, DegV family COG1307; Region: DegV; cl00577 691437008094 Fic/DOC family N-terminal; Region: Fic_N; pfam13784 691437008095 Fic/DOC family; Region: Fic; cl00960 691437008096 Protein of unknown function (DUF520); Region: DUF520; cl00723 691437008097 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 691437008098 This family of ATP-binding proteins belongs to a multisubunit transporter involved in drug resistance (BcrA and DrrA), nodulation, lipid transport, and lantibiotic immunity. In bacteria and archaea, these transporters usually include an ATP-binding...; Region: ABC_DR_subfamily_A; cd03230 691437008099 Walker A/P-loop; other site 691437008100 ATP binding site [chemical binding]; other site 691437008101 Q-loop/lid; other site 691437008102 ABC transporter signature motif; other site 691437008103 Walker B; other site 691437008104 D-loop; other site 691437008105 H-loop/switch region; other site 691437008106 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; cl00986 691437008107 DinB superfamily; Region: DinB_2; pfam12867 691437008108 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 691437008109 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD3; cd08297 691437008110 NAD binding site [chemical binding]; other site 691437008111 substrate binding site [chemical binding]; other site 691437008112 catalytic Zn binding site [ion binding]; other site 691437008113 tetramer interface [polypeptide binding]; other site 691437008114 structural Zn binding site [ion binding]; other site 691437008115 Ralstonia eutrophus NAD+-dependent acetaldehyde dehydrogenase II-like; Region: ALDH_ACDHII-AcoD; cd07116 691437008116 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 691437008117 NAD(P) binding site [chemical binding]; other site 691437008118 catalytic residues [active] 691437008119 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 691437008120 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 691437008121 active site 691437008122 phosphorylation site [posttranslational modification] 691437008123 intermolecular recognition site; other site 691437008124 dimerization interface [polypeptide binding]; other site 691437008125 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 691437008126 Walker A motif; other site 691437008127 ATP binding site [chemical binding]; other site 691437008128 Walker B motif; other site 691437008129 arginine finger; other site 691437008130 Helix-turn-helix domains; Region: HTH; cl00088 691437008131 GAF domain; Region: GAF; cl15785 691437008132 GAF domain; Region: GAF_2; pfam13185 691437008133 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 691437008134 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 691437008135 dimer interface [polypeptide binding]; other site 691437008136 phosphorylation site [posttranslational modification] 691437008137 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 691437008138 ATP binding site [chemical binding]; other site 691437008139 Mg2+ binding site [ion binding]; other site 691437008140 G-X-G motif; other site 691437008141 Iron-containing alcohol dehydrogenases-like; Region: Fe-ADH4; cd08188 691437008142 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 691437008143 putative active site [active] 691437008144 metal binding site [ion binding]; metal-binding site 691437008145 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 691437008146 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 691437008147 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 691437008148 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 691437008149 dimer interface [polypeptide binding]; other site 691437008150 conserved gate region; other site 691437008151 putative PBP binding loops; other site 691437008152 ABC-ATPase subunit interface; other site 691437008153 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 691437008154 dimer interface [polypeptide binding]; other site 691437008155 conserved gate region; other site 691437008156 putative PBP binding loops; other site 691437008157 ABC-ATPase subunit interface; other site 691437008158 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 691437008159 PotA is an ABC-type transporter and the ATPase component of the spermidine/putrescine-preferential uptake system consisting of PotA, -B, -C, and -D. PotA has two domains with the N-terminal domain containing the ATPase activity and the residues required...; Region: ABC_PotA_N; cd03300 691437008160 Walker A/P-loop; other site 691437008161 ATP binding site [chemical binding]; other site 691437008162 Q-loop/lid; other site 691437008163 ABC transporter signature motif; other site 691437008164 Walker B; other site 691437008165 D-loop; other site 691437008166 H-loop/switch region; other site 691437008167 TOBE domain; Region: TOBE_2; cl01440 691437008168 ABC-type transport system involved in cytochrome c biogenesis, ATPase component [Posttranslational modification, protein turnover, chaperones]; Region: CcmA; COG4133 691437008169 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 691437008170 Walker A/P-loop; other site 691437008171 ATP binding site [chemical binding]; other site 691437008172 Q-loop/lid; other site 691437008173 ABC transporter signature motif; other site 691437008174 Walker B; other site 691437008175 D-loop; other site 691437008176 H-loop/switch region; other site 691437008177 Integral membrane protein DUF95; Region: DUF95; cl00572 691437008178 Bacteriocin class IId cyclical uberolysin-like; Region: Bacteriocin_IId; cl12130 691437008179 type I secretion system ATPase, LssB family; Region: type_I_sec_LssB; TIGR03375 691437008180 zinc-ribbon domain; Region: zf-ribbon_3; cl11198 691437008181 bifunctional homocysteine S-methyltransferase/5,10-methylenetetrahydrofolate reductase protein; Reviewed; Region: PRK08645 691437008182 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; cl14105 691437008183 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 691437008184 FAD binding site [chemical binding]; other site 691437008185 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; cl14105 691437008186 5-methyltetrahydrofolate--homocysteine methyltransferase; Region: metH; TIGR02082 691437008187 MeTr subgroup of pterin binding enzymes. This family includes cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). Cobalamin-dependent...; Region: MeTr; cd00740 691437008188 substrate binding pocket [chemical binding]; other site 691437008189 B12 binding domain of methionine synthase. This domain binds methylcobalamin, which it uses as an intermediate methyl carrier from methyltetrahydrofolate (CH3H4folate) to homocysteine (Hcy); Region: methionine_synthase_B12_BD; cd02069 691437008190 B12 binding site [chemical binding]; other site 691437008191 cobalt ligand [ion binding]; other site 691437008192 Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965 691437008193 PIN domain of ribonucleases (toxins), VapC, FitB, and PAE0151 of bacterial and archaeal toxin/antitoxin-like operons, and other similar homologs; Region: PIN_VapC-like; cd09861 691437008194 putative active site [active] 691437008195 Antidote-toxin recognition MazE; Region: Antitoxin-MazE; cl00877 691437008196 short chain dehydrogenase; Provisional; Region: PRK06701 691437008197 classical (c) SDR, subgroup 1; Region: SDR_c1; cd05355 691437008198 NAD binding site [chemical binding]; other site 691437008199 metal binding site [ion binding]; metal-binding site 691437008200 active site 691437008201 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 691437008202 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 691437008203 E3 interaction surface; other site 691437008204 lipoyl attachment site [posttranslational modification]; other site 691437008205 e3 binding domain; Region: E3_binding; pfam02817 691437008206 e3 binding domain; Region: E3_binding; pfam02817 691437008207 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; cl02008 691437008208 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 691437008209 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 691437008210 alpha subunit interface [polypeptide binding]; other site 691437008211 TPP binding site [chemical binding]; other site 691437008212 heterodimer interface [polypeptide binding]; other site 691437008213 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 691437008214 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_y; TIGR03182 691437008215 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 691437008216 tetramer interface [polypeptide binding]; other site 691437008217 TPP-binding site [chemical binding]; other site 691437008218 heterodimer interface [polypeptide binding]; other site 691437008219 phosphorylation loop region [posttranslational modification] 691437008220 Transcriptional activator of acetoin/glycerol metabolism [Secondary metabolites biosynthesis, transport, and catabolism / Transcription]; Region: AcoR; COG3284 691437008221 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 691437008222 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 691437008223 Walker A motif; other site 691437008224 ATP binding site [chemical binding]; other site 691437008225 Walker B motif; other site 691437008226 arginine finger; other site 691437008227 Helix-turn-helix domains; Region: HTH; cl00088 691437008228 Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657 691437008229 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 691437008230 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 691437008231 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 691437008232 Domain of unknown function (DUF1932); Region: DUF1932; pfam09130 691437008233 Demethylmenaquinone methyltransferase; Region: Methyltransf_6; cl00480 691437008234 hypothetical protein; Validated; Region: PRK06201 691437008235 GlcNAc-PI de-N-acetylase; Region: PIG-L; cl00929 691437008236 Transcriptional regulators [Transcription]; Region: FadR; COG2186 691437008237 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 691437008238 DNA-binding site [nucleotide binding]; DNA binding site 691437008239 FCD domain; Region: FCD; cl11656 691437008240 N-terminal, non-catalytic, domain of BphC_JF8, (2,3-dihydroxybiphenyl 1,2-dioxygenase) from Bacillus sp. JF8 and similar proteins; Region: BphC-JF8_N_like; cd09013 691437008241 tetramer interface [polypeptide binding]; other site 691437008242 catechol 2,3 dioxygenase; Region: catechol_2_3; TIGR03211 691437008243 C-terminal, catalytic, domain of BphC_JF8, (2,3-dihydroxybiphenyl 1,2-dioxygenase) from Bacillus sp. JF8 and similar proteins; Region: BphC-JF8_C_like; cd09014 691437008244 tetramer interface [polypeptide binding]; other site 691437008245 active site 691437008246 metal binding site [ion binding]; metal-binding site 691437008247 Antibiotic biosynthesis monooxygenase; Region: ABM; cl10022 691437008248 O-methyltransferase; Region: Methyltransf_3; pfam01596 691437008249 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 691437008250 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 691437008251 dimer interface [polypeptide binding]; other site 691437008252 phosphorylation site [posttranslational modification] 691437008253 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 691437008254 ATP binding site [chemical binding]; other site 691437008255 Mg2+ binding site [ion binding]; other site 691437008256 G-X-G motif; other site 691437008257 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 691437008258 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 691437008259 active site 691437008260 phosphorylation site [posttranslational modification] 691437008261 intermolecular recognition site; other site 691437008262 dimerization interface [polypeptide binding]; other site 691437008263 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 691437008264 DNA binding site [nucleotide binding] 691437008265 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 691437008266 FtsX-like permease family; Region: FtsX; cl15850 691437008267 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 691437008268 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 691437008269 Walker A/P-loop; other site 691437008270 ATP binding site [chemical binding]; other site 691437008271 Q-loop/lid; other site 691437008272 ABC transporter signature motif; other site 691437008273 Walker B; other site 691437008274 D-loop; other site 691437008275 H-loop/switch region; other site 691437008276 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 691437008277 E3 interaction surface; other site 691437008278 lipoyl attachment site [posttranslational modification]; other site 691437008279 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 691437008280 Transcriptional regulators [Transcription]; Region: PurR; COG1609 691437008281 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 691437008282 DNA binding site [nucleotide binding] 691437008283 domain linker motif; other site 691437008284 Ligand-binding domain of uncharacterized transcription regulator ycjW which is a member of the LacI-GalR family repressors; Region: PBP1_ycjW_transcription_regulator_like; cd06294 691437008285 putative dimerization interface [polypeptide binding]; other site 691437008286 putative ligand binding site [chemical binding]; other site 691437008287 trehalose synthase; Region: treS_nterm; TIGR02456 691437008288 Alpha amylase catalytic domain found in bacterial cyclomaltodextrinases and related proteins; Region: AmyAc_bac_CMD_like_2; cd11339 691437008289 active site 691437008290 catalytic site [active] 691437008291 ABC-type maltose transport systems, permease component [Carbohydrate transport and metabolism]; Region: MalG; COG3833 691437008292 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 691437008293 dimer interface [polypeptide binding]; other site 691437008294 conserved gate region; other site 691437008295 putative PBP binding loops; other site 691437008296 ABC-ATPase subunit interface; other site 691437008297 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 691437008298 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 691437008299 dimer interface [polypeptide binding]; other site 691437008300 conserved gate region; other site 691437008301 putative PBP binding loops; other site 691437008302 ABC-ATPase subunit interface; other site 691437008303 Maltose-binding periplasmic proteins/domains [Carbohydrate transport and metabolism]; Region: MalE; COG2182 691437008304 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 691437008305 maltodextrin glucosidase; Provisional; Region: PRK10785 691437008306 N-terminal Early set domain associated with the catalytic domain of cyclomaltodextrinase and pullulan-degrading enzymes; Region: E_set_CDase_PDE_N; cd02857 691437008307 homodimer interface [polypeptide binding]; other site 691437008308 Alpha amylase catalytic domain found in cyclomaltodextrinases and related proteins; Region: AmyAc_CMD; cd11338 691437008309 active site 691437008310 homodimer interface [polypeptide binding]; other site 691437008311 catalytic site [active] 691437008312 Cyclo-malto-dextrinase C-terminal domain; Region: Cyc-maltodext_C; pfam10438 691437008313 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 691437008314 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 691437008315 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 691437008316 MatE; Region: MatE; cl10513 691437008317 MatE; Region: MatE; cl10513 691437008318 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 691437008319 active site 691437008320 asparagine synthase (glutamine-hydrolyzing); Region: asn_synth_AEB; TIGR01536 691437008321 dimer interface [polypeptide binding]; other site 691437008322 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 691437008323 Ligand Binding Site [chemical binding]; other site 691437008324 Molecular Tunnel; other site 691437008325 Protein of unknown function (DUF2777); Region: DUF2777; pfam10949 691437008326 FIST N domain; Region: FIST; cl10701 691437008327 FIST C domain; Region: FIST_C; pfam10442 691437008328 PAS domain S-box; Region: sensory_box; TIGR00229 691437008329 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 691437008330 putative active site [active] 691437008331 heme pocket [chemical binding]; other site 691437008332 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 691437008333 metal binding site [ion binding]; metal-binding site 691437008334 active site 691437008335 I-site; other site 691437008336 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 691437008337 Protein of unknown function (DUF1516); Region: DUF1516; cl11654 691437008338 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 691437008339 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 691437008340 Spo0E like sporulation regulatory protein; Region: SpoOE-like; pfam09388 691437008341 Predicted membrane protein [Function unknown]; Region: COG2311 691437008342 Protein of unknown function (DUF418); Region: DUF418; cl12135 691437008343 Protein of unknown function (DUF418); Region: DUF418; cl12135 691437008344 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187 691437008345 AMP-binding enzyme; Region: AMP-binding; cl15778 691437008346 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 691437008347 Spore germination protein gerPA/gerPF; Region: gerPA; pfam10676 691437008348 Spore germination protein gerPA/gerPF; Region: gerPA; pfam10676 691437008349 Spore germination protein gerPA/gerPF; Region: gerPA; pfam10676 691437008350 Protein of unknown function (DUF2539); Region: DUF2539; pfam10803 691437008351 Spore germination protein GerPC; Region: GerPC; pfam10737 691437008352 Protein of unknown function (DUF2772); Region: DUF2772; pfam10970 691437008353 Spore germination protein gerPA/gerPF; Region: gerPA; pfam10676 691437008354 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: SbcC; COG0419 691437008355 SbcCD and other Mre11/Rad50 (MR) complexes are implicated in the metabolism of DNA ends. They cleave ends sealed by hairpin structures and are thought to play a role in removing protein bound to DNA termini; Region: ABC_sbcCD; cd03279 691437008356 Walker A/P-loop; other site 691437008357 ATP binding site [chemical binding]; other site 691437008358 Q-loop/lid; other site 691437008359 ABC transporter signature motif; other site 691437008360 exonuclease subunit SbcC; Provisional; Region: PRK10246 691437008361 SbcCD and other Mre11/Rad50 (MR) complexes are implicated in the metabolism of DNA ends. They cleave ends sealed by hairpin structures and are thought to play a role in removing protein bound to DNA termini; Region: ABC_sbcCD; cd03279 691437008362 Q-loop/lid; other site 691437008363 ABC transporter signature motif; other site 691437008364 Walker B; other site 691437008365 D-loop; other site 691437008366 H-loop/switch region; other site 691437008367 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 691437008368 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 691437008369 active site 691437008370 metal binding site [ion binding]; metal-binding site 691437008371 DNA binding site [nucleotide binding] 691437008372 Type 5 capsule protein repressor C-terminal domain; Region: SbcD_C; pfam12320 691437008373 helicase-exonuclease AddAB, AddA subunit, Firmicutes type; Region: addA_Gpos; TIGR02785 691437008374 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 691437008375 Family description; Region: UvrD_C_2; cl15862 691437008376 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641 691437008377 helicase-exonuclease AddAB, AddB subunit; Region: addB_Gpos; TIGR02773 691437008378 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641 691437008379 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 691437008380 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 691437008381 Catalytic site [active] 691437008382 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 691437008383 ComK protein; Region: ComK; cl11560 691437008384 PEP phosphonomutase and related enzymes [Carbohydrate transport and metabolism]; Region: PrpB; COG2513 691437008385 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 691437008386 tetramer interface [polypeptide binding]; other site 691437008387 active site 691437008388 Mg2+/Mn2+ binding site [ion binding]; other site 691437008389 Uncharacterized protein SCO1/SenC/PrrC, involved in biogenesis of respiratory and photosynthetic systems [General function prediction only]; Region: COG1999 691437008390 SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968 691437008391 Cu(I) binding site [ion binding]; other site 691437008392 Branched-chain amino acid transport protein (AzlD); Region: AzlD; cl00735 691437008393 AzlC protein; Region: AzlC; cl00570 691437008394 D-Alanine aminotransferase (D-AAT_like): D-amino acid aminotransferase catalyzes transamination between D-amino acids and their respective alpha-keto acids. It plays a major role in the synthesis of bacterial cell wall components like D-alanine and...; Region: D-AAT_like; cd01558 691437008395 homodimer interface [polypeptide binding]; other site 691437008396 substrate-cofactor binding pocket; other site 691437008397 pyridoxal 5'-phosphate binding site [chemical binding]; other site 691437008398 catalytic residue [active] 691437008399 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: PhnK; COG1101 691437008400 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 691437008401 Walker A/P-loop; other site 691437008402 ATP binding site [chemical binding]; other site 691437008403 Q-loop/lid; other site 691437008404 ABC transporter signature motif; other site 691437008405 Walker B; other site 691437008406 D-loop; other site 691437008407 H-loop/switch region; other site 691437008408 Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cd06574 691437008409 TM-ABC transporter signature motif; other site 691437008410 Type I periplasmic ligand-binding domain of uncharacterized ABC-type transport systems that are predicted to be involved in the uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_uncharacterized_transporter; cd06325 691437008411 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 691437008412 zinc binding site [ion binding]; other site 691437008413 putative ligand binding site [chemical binding]; other site 691437008414 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07656 691437008415 AMP-binding enzyme; Region: AMP-binding; cl15778 691437008416 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 691437008417 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 691437008418 YhfH-like protein; Region: YhfH; pfam14149 691437008419 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 691437008420 Helix-turn-helix domains; Region: HTH; cl00088 691437008421 protoporphyrinogen oxidase; Reviewed; Region: PRK11883 691437008422 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 691437008423 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 691437008424 ferrochelatase; Provisional; Region: PRK12435 691437008425 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 691437008426 C-terminal domain interface [polypeptide binding]; other site 691437008427 active site 691437008428 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 691437008429 active site 691437008430 N-terminal domain interface [polypeptide binding]; other site 691437008431 methyltransferase, MtaA/CmuA family; Region: mtaA_cmuA; TIGR01463 691437008432 Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717 691437008433 substrate binding site [chemical binding]; other site 691437008434 active site 691437008435 Citrate transporter; Region: CitMHS; pfam03600 691437008436 Bacterial ABC transporter protein EcsB; Region: EcsB; cl11542 691437008437 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 691437008438 This family of ATP-binding proteins belongs to a multisubunit transporter involved in drug resistance (BcrA and DrrA), nodulation, lipid transport, and lantibiotic immunity. In bacteria and archaea, these transporters usually include an ATP-binding...; Region: ABC_DR_subfamily_A; cd03230 691437008439 Walker A/P-loop; other site 691437008440 ATP binding site [chemical binding]; other site 691437008441 Q-loop/lid; other site 691437008442 ABC transporter signature motif; other site 691437008443 Walker B; other site 691437008444 D-loop; other site 691437008445 H-loop/switch region; other site 691437008446 HINT (histidine triad nucleotide-binding protein) subgroup: Members of this CD belong to the superfamily of histidine triad hydrolases that act on alpha-phosphate of ribonucleotides. This subgroup includes members from all three forms of cellular life; Region: HINT_subgroup; cd01277 691437008447 HIT family signature motif; other site 691437008448 catalytic residue [active] 691437008449 peptidylprolyl isomerase; Reviewed; Region: prsA; PRK02998 691437008450 PPIC-type PPIASE domain; Region: Rotamase; cl08278 691437008451 Protein of unknown function (DUF1878); Region: DUF1878; pfam08963 691437008452 transcriptional regulator Hpr; Provisional; Region: PRK13777 691437008453 Helix-turn-helix domains; Region: HTH; cl00088 691437008454 Phosphoserine aminotransferase (PSAT) family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major group in this CD corresponds to phosphoserine aminotransferase (PSAT). PSAT is active as...; Region: PSAT_like; cd00611 691437008455 homodimer interface [polypeptide binding]; other site 691437008456 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 691437008457 substrate-cofactor binding pocket; other site 691437008458 pyridoxal 5'-phosphate binding site [chemical binding]; other site 691437008459 catalytic residue [active] 691437008460 Sporulation protein YhaL; Region: Spore_YhaL; pfam14147 691437008461 3'-5' exoribonuclease YhaM; Provisional; Region: PRK13480 691437008462 YhaM_OBF_like: A subfamily of OB folds similar to that found in Bacillus subtilis YhaM and Staphylococcus aureus cmp-binding factor-1 (SaCBF1). Both these proteins are 3'-to-5'exoribonucleases. YhaM requires Mn2+ or Co2+ for activity and is inactive in...; Region: YhaM_OBF_like; cd04492 691437008463 generic binding surface II; other site 691437008464 generic binding surface I; other site 691437008465 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 691437008466 ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668 691437008467 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4152 691437008468 This subfamily is involved in drug resistance, nodulation, lipid transport, and bacteriocin and lantibiotic immunity. In eubacteria and archaea, the typical organization consists of one ABC and one or two IMs. Eukaryote systems of the ABCA subfamily...; Region: ABC_putative_ATPase; cd03269 691437008469 Walker A/P-loop; other site 691437008470 ATP binding site [chemical binding]; other site 691437008471 Q-loop/lid; other site 691437008472 ABC transporter signature motif; other site 691437008473 Walker B; other site 691437008474 D-loop; other site 691437008475 H-loop/switch region; other site 691437008476 Domain of unknown function (DUF4162); Region: DUF4162; pfam13732 691437008477 YhzD-like protein; Region: YhzD; pfam14120 691437008478 coproporphyrinogen III oxidase; Provisional; Region: PRK08207 691437008479 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cl15377 691437008480 FeS/SAM binding site; other site 691437008481 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 691437008482 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 691437008483 active site 691437008484 motif I; other site 691437008485 motif II; other site 691437008486 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 691437008487 Protein of unknown function (DUF964); Region: DUF964; cl01483 691437008488 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4399 691437008489 ATP-grasp domain; Region: ATP-grasp_4; cl03087 691437008490 ATP-grasp domain; Region: ATP-grasp_4; cl03087 691437008491 ATP-grasp domain; Region: ATP-grasp_4; cl03087 691437008492 ATP-grasp domain; Region: ATP-grasp_4; cl03087 691437008493 Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508 691437008494 Helix-turn-helix domains; Region: HTH; cl00088 691437008495 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 691437008496 The N-terminal ATPase domain of the maltose transporter, MalK. ATP binding cassette (ABC) proteins function from bacteria to human, mediating the translocation of substances into and out of cells or organelles. ABC transporters contain two...; Region: ABC_MalK_N; cd03301 691437008497 Walker A/P-loop; other site 691437008498 ATP binding site [chemical binding]; other site 691437008499 Q-loop/lid; other site 691437008500 ABC transporter signature motif; other site 691437008501 Walker B; other site 691437008502 D-loop; other site 691437008503 H-loop/switch region; other site 691437008504 TOBE domain; Region: TOBE_2; cl01440 691437008505 Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269 691437008506 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 691437008507 Domain of unknown function DUF21; Region: DUF21; pfam01595 691437008508 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 691437008509 Transporter associated domain; Region: CorC_HlyC; cl08393 691437008510 thiamine/molybdopterin biosynthesis ThiF/MoeB-like protein; Validated; Region: PRK07688 691437008511 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 691437008512 ATP binding site [chemical binding]; other site 691437008513 substrate interface [chemical binding]; other site 691437008514 Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728 691437008515 ThiS interaction site; other site 691437008516 putative active site [active] 691437008517 tetramer interface [polypeptide binding]; other site 691437008518 ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565 691437008519 thiS-thiF/thiG interaction site; other site 691437008520 glycine oxidase ThiO; Region: thiamin_ThiO; TIGR02352 691437008521 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 691437008522 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 691437008523 thiamine phosphate binding site [chemical binding]; other site 691437008524 active site 691437008525 pyrophosphate binding site [ion binding]; other site 691437008526 Cobalt transport protein; Region: CbiQ; cl00463 691437008527 Domain I of the ABC component of a cobalt transport family found in bacteria, archaea, and eukaryota. The transition metal cobalt is an essential component of many enzymes and must be transported into cells in appropriate amounts when needed. This ABC...; Region: ABC_cobalt_CbiO_domain1; cd03225 691437008528 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 691437008529 Walker A/P-loop; other site 691437008530 ATP binding site [chemical binding]; other site 691437008531 Q-loop/lid; other site 691437008532 ABC transporter signature motif; other site 691437008533 Walker B; other site 691437008534 D-loop; other site 691437008535 H-loop/switch region; other site 691437008536 cobalt transport protein ATP-binding subunit; Region: cbiO; TIGR01166 691437008537 Domain I of the ABC component of a cobalt transport family found in bacteria, archaea, and eukaryota. The transition metal cobalt is an essential component of many enzymes and must be transported into cells in appropriate amounts when needed. This ABC...; Region: ABC_cobalt_CbiO_domain1; cd03225 691437008538 Walker A/P-loop; other site 691437008539 ATP binding site [chemical binding]; other site 691437008540 Q-loop/lid; other site 691437008541 ABC transporter signature motif; other site 691437008542 Walker B; other site 691437008543 D-loop; other site 691437008544 H-loop/switch region; other site 691437008545 ABC-type cobalt transport system, permease component; Region: ABC_cobalt; cl01943 691437008546 Heme oxygenase catalyzes the rate limiting step in the degradation of heme to bilirubin, it is essential for recycling of iron from heme. Heme is used as a substrate and cofactor for its own degradation to biliverdin, iron, and carbon monoxide. This...; Region: HemeO; cl15243 691437008547 PUA domain; Region: PUA; cl00607 691437008548 Predicted SAM-dependent methyltransferases [General function prediction only]; Region: COG1092 691437008549 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 691437008550 S-adenosylmethionine binding site [chemical binding]; other site 691437008551 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 691437008552 putative transporter; Provisional; Region: PRK12382 691437008553 putative substrate translocation pore; other site 691437008554 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; cl00986 691437008555 DinB superfamily; Region: DinB_2; pfam12867 691437008556 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 691437008557 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 691437008558 Ca binding site [ion binding]; other site 691437008559 active site 691437008560 catalytic site [active] 691437008561 2-dehydropantoate 2-reductase; Provisional; Region: PRK12921 691437008562 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 691437008563 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 691437008564 Protein of unknown function (DUF466); Region: DUF466; cl01082 691437008565 carbon starvation protein A; Provisional; Region: PRK15015 691437008566 Carbon starvation protein CstA; Region: CstA; pfam02554 691437008567 C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722 691437008568 Integral membrane protein TerC family; Region: TerC; cl10468 691437008569 Small Multidrug Resistance protein; Region: Multi_Drug_Res; cl00910 691437008570 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; cl00562 691437008571 Uncharacterized conserved protein [Function unknown]; Region: SpoVR; COG2719 691437008572 SpoVR like protein; Region: SpoVR; pfam04293 691437008573 PAP2_like proteins, BcrC_like subfamily. Several members of this family have been annotated as bacitracin transport permeases, as it was suspected that they form the permease component of an ABC transporter system. It was shown, however, that BcrC from...; Region: PAP2_BcrC_like; cd03385 691437008574 active site 691437008575 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 691437008576 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 691437008577 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 691437008578 dimer interface [polypeptide binding]; other site 691437008579 phosphorylation site [posttranslational modification] 691437008580 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 691437008581 ATP binding site [chemical binding]; other site 691437008582 Mg2+ binding site [ion binding]; other site 691437008583 G-X-G motif; other site 691437008584 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 691437008585 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 691437008586 YhdB-like protein; Region: YhdB; pfam14148 691437008587 phosphoglucomutase-2-like protein; Provisional; Region: PTZ00150 691437008588 This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...; Region: PGM2; cd05799 691437008589 active site 691437008590 substrate binding site [chemical binding]; other site 691437008591 metal binding site [ion binding]; metal-binding site 691437008592 FOG: CBS domain [General function prediction only]; Region: COG0517 691437008593 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_9; cd04622 691437008594 Disulfide bond formation protein DsbB; Region: DsbB; cl00649 691437008595 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 691437008596 catalytic residues [active] 691437008597 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 691437008598 PseudoU_synth_RsuA/RluD: Pseudouridine synthase, RsuA/RluD family. This group is comprised of eukaryotic, bacterial and archeal proteins similar to eight site specific Escherichia coli pseudouridine synthases: RsuA, RluA, RluB, RluC, RluD, RluE, RluF and...; Region: PseudoU_synth_RluCD_like; cd02869 691437008599 active site 691437008600 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 691437008601 Domain of unknown function DUF21; Region: DUF21; pfam01595 691437008602 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 691437008603 Transporter associated domain; Region: CorC_HlyC; cl08393 691437008604 Putative neutral zinc metallopeptidase; Region: Zn_peptidase_2; cl01049 691437008605 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 691437008606 active site 691437008607 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 691437008608 catalytic tetrad [active] 691437008609 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 691437008610 Sodium:dicarboxylate symporter family; Region: SDF; cl00573 691437008611 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 691437008612 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441 691437008613 Signal transduction histidine kinase regulating citrate/malate metabolism [Signal transduction mechanisms]; Region: CitA; COG3290 691437008614 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 691437008615 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 691437008616 ATP binding site [chemical binding]; other site 691437008617 Mg2+ binding site [ion binding]; other site 691437008618 G-X-G motif; other site 691437008619 Response regulator of citrate/malate metabolism [Transcription / Signal transduction mechanisms]; Region: CitB; COG4565 691437008620 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 691437008621 active site 691437008622 phosphorylation site [posttranslational modification] 691437008623 intermolecular recognition site; other site 691437008624 dimerization interface [polypeptide binding]; other site 691437008625 Helix-turn-helix domains; Region: HTH; cl00088 691437008626 Uncharacterized conserved protein [Function unknown]; Region: COG2718 691437008627 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 691437008628 Putative Ser protein kinase [Signal transduction mechanisms]; Region: PrkA; COG2766 691437008629 PrkA serine protein kinase C-terminal domain; Region: PrkA; pfam06798 691437008630 SpoU rRNA Methylase family; Region: SpoU_methylase; cl00362 691437008631 NlpC/P60 family; Region: NLPC_P60; cl11438 691437008632 Uncharacterized Fe-S protein [Energy production and conversion]; Region: COG1600 691437008633 Domain of unknown function (DUF1730); Region: DUF1730; pfam08331 691437008634 B3/4 domain; Region: B3_4; cl11458 691437008635 Protein of unknown function (DUF2614); Region: DUF2614; cl07936 691437008636 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 691437008637 metal binding site 2 [ion binding]; metal-binding site 691437008638 putative DNA binding helix; other site 691437008639 metal binding site 1 [ion binding]; metal-binding site 691437008640 dimer interface [polypeptide binding]; other site 691437008641 structural Zn2+ binding site [ion binding]; other site 691437008642 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 691437008643 catalytic triad [active] 691437008644 Ion channel; Region: Ion_trans_2; cl11596 691437008645 L-lactate dehydrogenase; Reviewed; Region: ldh; PRK00066 691437008646 L-2-hydroxyisocapronate dehydrogenases and some bacterial L-lactate dehydrogenases; Region: HicDH_like; cd05291 691437008647 tetramer (dimer of dimers) interface [polypeptide binding]; other site 691437008648 NAD binding site [chemical binding]; other site 691437008649 dimer interface [polypeptide binding]; other site 691437008650 substrate binding site [chemical binding]; other site 691437008651 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4587 691437008652 ABC-2 family transporter protein; Region: ABC2_membrane_6; cl01496 691437008653 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4587 691437008654 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4586 691437008655 Similar in sequence to NatA, this is the ATPase component of a bacterial ABC-type Na+ transport system called NatAB, which catalyzes ATP-dependent electrogenic Na+ extrusion without mechanically coupled to proton or K+ uptake. NatB possess six putative...; Region: ABC_NatA_like; cd03267 691437008656 Walker A/P-loop; other site 691437008657 ATP binding site [chemical binding]; other site 691437008658 Q-loop/lid; other site 691437008659 ABC transporter signature motif; other site 691437008660 Walker B; other site 691437008661 D-loop; other site 691437008662 H-loop/switch region; other site 691437008663 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK12389 691437008664 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 691437008665 inhibitor-cofactor binding pocket; inhibition site 691437008666 pyridoxal 5'-phosphate binding site [chemical binding]; other site 691437008667 catalytic residue [active] 691437008668 Predicted membrane protein [Function unknown]; Region: COG4129 691437008669 Fusaric acid resistance protein-like; Region: FUSC_2; cl15844 691437008670 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 691437008671 glutathione ABC transporter permease GsiD; Provisional; Region: PRK15082 691437008672 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 691437008673 dimer interface [polypeptide binding]; other site 691437008674 conserved gate region; other site 691437008675 ABC-ATPase subunit interface; other site 691437008676 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 691437008677 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 691437008678 dimer interface [polypeptide binding]; other site 691437008679 conserved gate region; other site 691437008680 putative PBP binding loops; other site 691437008681 ABC-ATPase subunit interface; other site 691437008682 The substrate-binding component of an ABC-type dipeptide import system contains the type 2 periplasmic binding fold; Region: PBP2_DppA_like; cd08493 691437008683 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 691437008684 peptide binding site [polypeptide binding]; other site 691437008685 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 691437008686 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 691437008687 Walker A/P-loop; other site 691437008688 ATP binding site [chemical binding]; other site 691437008689 Q-loop/lid; other site 691437008690 ABC transporter signature motif; other site 691437008691 Walker B; other site 691437008692 D-loop; other site 691437008693 H-loop/switch region; other site 691437008694 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 691437008695 Protein of unknown function (DUF402); Region: DUF402; cl00979 691437008696 YgaB-like protein; Region: YgaB; pfam14182 691437008697 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 691437008698 1-cyclohexenylcarbonyl_coenzyme A_reductase (ChcA)_like, classical (c) SDRs; Region: ChcA_like_SDR_c; cd05359 691437008699 putative NAD(P) binding site [chemical binding]; other site 691437008700 active site 691437008701 A/G-specific DNA glycosylase [DNA replication, recombination, and repair]; Region: MutY; COG1194 691437008702 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 691437008703 minor groove reading motif; other site 691437008704 helix-hairpin-helix signature motif; other site 691437008705 substrate binding pocket [chemical binding]; other site 691437008706 active site 691437008707 Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; cl15304 691437008708 DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431 691437008709 DNA binding and oxoG recognition site [nucleotide binding] 691437008710 Oxalate/Formate Antiporter; Region: 2A0111; TIGR00890 691437008711 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 691437008712 putative substrate translocation pore; other site 691437008713 FdhD/NarQ family; Region: FdhD-NarQ; cl00659 691437008714 Uncharacterized conserved protein (DUF2294); Region: DUF2294; cl02390 691437008715 Uncharacterized anaerobic dehydrogenase [General function prediction only]; Region: COG3383 691437008716 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 691437008717 catalytic loop [active] 691437008718 iron binding site [ion binding]; other site 691437008719 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; cl11210 691437008720 4Fe-4S binding domain; Region: Fer4; cl02805 691437008721 Formate dehydrogenase H (Formate-Dh-H) catalyzes the reversible oxidation of formate to CO2 with the release of a proton and two electrons. It is a component of the anaerobic formate hydrogen lyase complex. The E. coli formate dehydrogenase H (Fdh-H) is...; Region: MopB_Formate-Dh-H; cd02753 691437008722 [4Fe-4S] binding site [ion binding]; other site 691437008723 molybdopterin cofactor binding site; other site 691437008724 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_CT_Formate-Dh-Na-like; cd02792 691437008725 molybdopterin cofactor binding site; other site 691437008726 Protein of unknown function (DUF1641); Region: DUF1641; cl01025 691437008727 Predicted membrane-bound metal-dependent hydrolase (DUF457); Region: DUF457; cl00868 691437008728 Small acid-soluble spore protein K family; Region: SspK; cl11509 691437008729 YpzG-like protein; Region: YpzG; pfam14139 691437008730 Protein of unknown function (DUF1811); Region: DUF1811; pfam08838 691437008731 RecX family; Region: RecX; cl00936 691437008732 atypical (a) SDRs, subgroup 8; Region: SDR_a8; cd05242 691437008733 TIGR01777 family protein; Region: yfcH 691437008734 putative NAD(P) binding site [chemical binding]; other site 691437008735 putative active site [active] 691437008736 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 691437008737 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 691437008738 YfhE-like protein; Region: YfhE; pfam14152 691437008739 YfhD-like protein; Region: YfhD; pfam14151 691437008740 A4GalT_like proteins catalyze the addition of galactose or glucose residues to the lipooligosaccharide (LOS) or lipopolysaccharide (LPS) of the bacterial cell surface; Region: GT8_A4GalT_like; cd04194 691437008741 Glycosyl transferase family 8; Region: Glyco_transf_8; pfam01501 691437008742 Ligand binding site; other site 691437008743 metal-binding site 691437008744 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 691437008745 CoA-transferase family III; Region: CoA_transf_3; pfam02515 691437008746 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 691437008747 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 691437008748 active site 691437008749 Domain of unknown function (DUF3870); Region: DUF3870; pfam12986 691437008750 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3002 691437008751 Uncharacterized protein conserved in bacteria (DUF2309); Region: DUF2309; pfam10070 691437008752 NADH dehydrogenase subunit 5; Validated; Region: PRK08601 691437008753 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; cl14187 691437008754 Uncharacterized conserved protein (DUF2294); Region: DUF2294; cl02390 691437008755 Predicted ATPase of the ABC class; Region: ABC_ATPase; pfam09818 691437008756 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 691437008757 Walker A/P-loop; other site 691437008758 ATP binding site [chemical binding]; other site 691437008759 ABC transporter signature motif; other site 691437008760 Walker B; other site 691437008761 D-loop; other site 691437008762 H-loop/switch region; other site 691437008763 Uncharacterized conserved protein [Function unknown]; Region: COG0397; cl00428 691437008764 Uncharacterized ACR, YdiU/UPF0061 family; Region: UPF0061; pfam02696 691437008765 integrating conjugative element protein, PFL_4705 family; Region: conj_TIGR03752 691437008766 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 691437008767 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 691437008768 active site 691437008769 phosphorylation site [posttranslational modification] 691437008770 intermolecular recognition site; other site 691437008771 dimerization interface [polypeptide binding]; other site 691437008772 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 691437008773 DNA binding residues [nucleotide binding] 691437008774 dimerization interface [polypeptide binding]; other site 691437008775 Histidine kinase; Region: HisKA_3; pfam07730 691437008776 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 691437008777 ATP binding site [chemical binding]; other site 691437008778 Mg2+ binding site [ion binding]; other site 691437008779 G-X-G motif; other site 691437008780 Predicted membrane protein [Function unknown]; Region: COG4758 691437008781 Cell wall-active antibiotics response protein (DUF2154); Region: DUF2154; pfam09922 691437008782 Phage shock protein A (IM30), suppresses sigma54-dependent transcription [Transcription / Signal transduction mechanisms]; Region: PspA; COG1842 691437008783 TRAM domain; Region: TRAM; cl01282 691437008784 23S rRNA (uracil-5-)-methyltransferase RumA; Region: rumA; TIGR00479 691437008785 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 691437008786 S-adenosylmethionine binding site [chemical binding]; other site 691437008787 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl15754 691437008788 3-methyladenine DNA glycosylase/8-oxoguanine DNA glycosylase [DNA replication, recombination, and repair]; Region: AlkA; COG0122 691437008789 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 691437008790 minor groove reading motif; other site 691437008791 helix-hairpin-helix signature motif; other site 691437008792 substrate binding pocket [chemical binding]; other site 691437008793 active site 691437008794 Catalytic NodB homology domain of Bacillus subtilis polysaccharide deacetylase PdaA, and its bacterial homologs; Region: CE4_BsPdaA_like; cd10948 691437008795 delta-lactam-biosynthetic de-N-acetylase; Region: spore_pdaA; TIGR02884 691437008796 NodB motif; other site 691437008797 active site 691437008798 catalytic site [active] 691437008799 Cd binding site [ion binding]; other site 691437008800 Fumarate hydratase (Fumerase); Region: Fumerase; cl00851 691437008801 fumarate hydratase FumB; Provisional; Region: PRK15391 691437008802 Fumarase C-terminus; Region: Fumerase_C; cl00795 691437008803 Radical SAM superfamily; Region: Radical_SAM; pfam04055 691437008804 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 691437008805 FeS/SAM binding site; other site 691437008806 YfkB-like domain; Region: YfkB; pfam08756 691437008807 YfkD-like protein; Region: YfkD; pfam14167 691437008808 calcium/proton exchanger (cax); Region: cax; TIGR00378 691437008809 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 691437008810 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 691437008811 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 691437008812 putative substrate translocation pore; other site 691437008813 Virulence factor BrkB; Region: Virul_fac_BrkB; cl07918 691437008814 Low molecular weight phosphatase family; Region: LMWPc; cd00115 691437008815 Low molecular weight phosphotyrosine protein phosphatase; Region: LMWPc; pfam01451 691437008816 active site 691437008817 Protein of unknown function (DUF1128); Region: DUF1128; cl11553 691437008818 3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes [Amino acid transport and metabolism / Coenzyme metabolism]; Region: CysH; COG0175 691437008819 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 691437008820 Active Sites [active] 691437008821 sulfate adenylyltransferase; Reviewed; Region: sat; PRK04149 691437008822 ATP-sulfurylase; Region: ATPS; cd00517 691437008823 active site 691437008824 HXXH motif; other site 691437008825 flexible loop; other site 691437008826 Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically 'activated' sulfate form important for the assimilation of...; Region: APSK; cd02027 691437008827 Gluconate kinase [Carbohydrate transport and metabolism]; Region: GntK; COG3265 691437008828 ligand-binding site [chemical binding]; other site 691437008829 Precorrin-3B methylase [Coenzyme metabolism]; Region: CobJ; cl00304 691437008830 Tetrapyrrole (Corrin/Porphyrin) Methylases; Region: TP_methylase; pfam00590 691437008831 Sirohydrochlorin ferrochelatase [Inorganic ion transport and metabolism]; Region: COG2138 691437008832 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_N; cd03416 691437008833 putative active site [active] 691437008834 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), C-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_C; cd03414 691437008835 putative active site [active] 691437008836 Acylphosphatase; Region: Acylphosphatase; cl00551 691437008837 Arginase family; Region: Arginase; cl00306 691437008838 Protein of unknown function (DUF1806); Region: DUF1806; pfam08830 691437008839 GlcNAc-PI de-N-acetylase; Region: PIG-L; cl00929 691437008840 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 691437008841 precorrin-2 dehydrogenase; Reviewed; Region: PRK06718 691437008842 DDE superfamily endonuclease; Region: DDE_5; cl02413 691437008843 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 691437008844 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 691437008845 H+ Antiporter protein; Region: 2A0121; TIGR00900 691437008846 putative substrate translocation pore; other site 691437008847 Cupin domain; Region: Cupin_2; cl09118 691437008848 Cupin domain; Region: Cupin_2; cl09118 691437008849 enolase; Provisional; Region: eno; PRK00077 691437008850 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 691437008851 dimer interface [polypeptide binding]; other site 691437008852 metal binding site [ion binding]; metal-binding site 691437008853 substrate binding pocket [chemical binding]; other site 691437008854 Phosphoglyceromutase [Carbohydrate transport and metabolism]; Region: GpmI; COG0696 691437008855 Sulfatase; Region: Sulfatase; cl10460 691437008856 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 691437008857 substrate binding site [chemical binding]; other site 691437008858 dimer interface [polypeptide binding]; other site 691437008859 catalytic triad [active] 691437008860 Phosphoglycerate kinase; Region: PGK; pfam00162 691437008861 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 691437008862 substrate binding site [chemical binding]; other site 691437008863 hinge regions; other site 691437008864 ADP binding site [chemical binding]; other site 691437008865 catalytic site [active] 691437008866 glyceraldehyde-3-phosphate dehydrogenase; Validated; Region: PRK07729 691437008867 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 691437008868 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; cl15856 691437008869 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 691437008870 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 691437008871 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 691437008872 RNA polymerase factor sigma-54; Reviewed; Region: PRK05932 691437008873 Sigma-54 factor, Activator interacting domain (AID); Region: Sigma54_AID; pfam00309 691437008874 Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963 691437008875 Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552 691437008876 Clp protease; Region: CLP_protease; pfam00574 691437008877 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 691437008878 oligomer interface [polypeptide binding]; other site 691437008879 active site residues [active] 691437008880 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 691437008881 dimerization domain swap beta strand [polypeptide binding]; other site 691437008882 regulatory protein interface [polypeptide binding]; other site 691437008883 active site 691437008884 regulatory phosphorylation site [posttranslational modification]; other site 691437008885 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1481 691437008886 Sporulation Regulator WhiA N terminal; Region: WhiA_N; pfam10298 691437008887 family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187 691437008888 phosphate binding site [ion binding]; other site 691437008889 putative substrate binding pocket [chemical binding]; other site 691437008890 dimer interface [polypeptide binding]; other site 691437008891 P-loop ATPase protein family; Region: ATP_bind_2; cl15794 691437008892 Predicted P-loop-containing kinase [General function prediction only]; Region: COG1660 691437008893 MutT homolog-1 (MTH1) is a member of the Nudix hydrolase superfamily. MTH1, the mammalian counterpart of MutT, hydrolyzes oxidized purine nucleoside triphosphates, such as 8-oxo-dGTP and 2-hydroxy-ATP, to monophosphates, thereby preventing the...; Region: MTH1; cd03427 691437008894 putative active site [active] 691437008895 nucleotide binding site [chemical binding]; other site 691437008896 nudix motif; other site 691437008897 putative metal binding site [ion binding]; other site 691437008898 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 691437008899 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 691437008900 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 691437008901 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 691437008902 binding surface 691437008903 TPR motif; other site 691437008904 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 691437008905 Phosphoribosyl-AMP cyclohydrolase; Region: PRA-CH; cl00344 691437008906 bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase protein; Reviewed; Region: PRK02759 691437008907 MazG nucleotide pyrophosphohydrolase domain; Region: MazG; cl00345 691437008908 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 691437008909 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 691437008910 substrate binding site [chemical binding]; other site 691437008911 glutamase interaction surface [polypeptide binding]; other site 691437008912 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 691437008913 phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Region: TIGR00007 691437008914 catalytic residues [active] 691437008915 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13141 691437008916 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 691437008917 putative active site [active] 691437008918 oxyanion strand; other site 691437008919 catalytic triad [active] 691437008920 imidazoleglycerol-phosphate dehydratase; Validated; Region: hisB; PRK00951 691437008921 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 691437008922 putative active site pocket [active] 691437008923 4-fold oligomerization interface [polypeptide binding]; other site 691437008924 metal binding residues [ion binding]; metal-binding site 691437008925 3-fold/trimer interface [polypeptide binding]; other site 691437008926 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 691437008927 histidinol dehydrogenase; Region: hisD; TIGR00069 691437008928 NAD binding site [chemical binding]; other site 691437008929 dimerization interface [polypeptide binding]; other site 691437008930 product binding site; other site 691437008931 substrate binding site [chemical binding]; other site 691437008932 zinc binding site [ion binding]; other site 691437008933 catalytic residues [active] 691437008934 ATP phosphoribosyltransferase; Region: HisG; cl15266 691437008935 ATP phosphoribosyltransferase regulatory subunit; Provisional; Region: hisZ; PRK12292 691437008936 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: HisRS-like_core; cd00773 691437008937 dimer interface [polypeptide binding]; other site 691437008938 motif 1; other site 691437008939 active site 691437008940 motif 2; other site 691437008941 motif 3; other site 691437008942 VanZ like family; Region: VanZ; cl01971 691437008943 Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647 691437008944 trimer interface [polypeptide binding]; other site 691437008945 active site 691437008946 substrate binding site [chemical binding]; other site 691437008947 CoA binding site [chemical binding]; other site 691437008948 pyrophosphatase PpaX; Provisional; Region: PRK13288 691437008949 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 691437008950 active site 691437008951 motif I; other site 691437008952 motif II; other site 691437008953 Nucleoside recognition; Region: Gate; cl00486 691437008954 Nucleoside recognition; Region: Gate; cl00486 691437008955 Prolipoprotein diacylglyceryl transferase; Region: LGT; cl00478 691437008956 HPr kinase/phosphorylase; Provisional; Region: PRK05428 691437008957 DRTGG domain; Region: DRTGG; cl12147 691437008958 HprK/P, the bifunctional histidine-containing protein kinase/phosphatase, controls the phosphorylation state of the phosphocarrier protein HPr and regulates the utilization of carbon sources by gram-positive bacteria. It catalyzes both the ATP-dependent...; Region: HprK_C; cd01918 691437008959 Hpr binding site; other site 691437008960 active site 691437008961 homohexamer subunit interaction site [polypeptide binding]; other site 691437008962 Membrane protein of unknown function; Region: DUF360; cl00850 691437008963 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 691437008964 The excision repair protein UvrA domain I; Nucleotide excision repair in eubacteria is a process that repairs DNA damage by the removal of a 12-13-mer oligonucleotide containing the lesion. Recognition and cleavage of the damaged DNA is a multistep...; Region: ABC_UvrA_I; cd03270 691437008965 The excision repair protein UvrA domain I; Nucleotide excision repair in eubacteria is a process that repairs DNA damage by the removal of a 12-13-mer oligonucleotide containing the lesion. Recognition and cleavage of the damaged DNA is a multistep...; Region: ABC_UvrA_I; cd03270 691437008966 The excision repair protein UvrA domain II; Nucleotide excision repair in eubacteria is a process that repairs DNA damage by the removal of a 12-13-mer oligonucleotide containing the lesion. Recognition and cleavage of the damaged DNA is a multistep...; Region: ABC_UvrA_II; cd03271 691437008967 excinuclease ABC subunit B; Provisional; Region: PRK05298 691437008968 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 691437008969 ATP binding site [chemical binding]; other site 691437008970 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 691437008971 nucleotide binding region [chemical binding]; other site 691437008972 ATP-binding site [chemical binding]; other site 691437008973 Ultra-violet resistance protein B; Region: UvrB; pfam12344 691437008974 Uncharacterized protein conserved in bacteria (DUF2198); Region: DUF2198; cl11559 691437008975 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 691437008976 polar chromosome segregation protein; Reviewed; Region: racA; PRK13182 691437008977 Helix-Turn-Helix DNA binding domain of truncated MerR-like proteins; Region: HTH_MerR-trunc; cd04762 691437008978 DNA binding residues [nucleotide binding] 691437008979 Predicted membrane protein (DUF2079); Region: DUF2079; pfam09852 691437008980 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 691437008981 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 691437008982 Ligand binding site; other site 691437008983 Putative Catalytic site; other site 691437008984 DXD motif; other site 691437008985 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 691437008986 C-terminal peptidase (prc); Region: prc; TIGR00225 691437008987 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 691437008988 protein binding site [polypeptide binding]; other site 691437008989 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 691437008990 Catalytic dyad [active] 691437008991 Putative peptidoglycan binding domain; Region: PG_binding_1; cl15437 691437008992 Cupin domain; Region: Cupin_2; cl09118 691437008993 Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726 691437008994 YusW-like protein; Region: YusW; pfam14039 691437008995 Helix-Turn-Helix DNA binding domain of the MerR1 transcription regulator; Region: HTH_MerR1; cd04783 691437008996 Hg(II)-responsive transcriptional regulator; Region: MerR; TIGR02051 691437008997 DNA binding residues [nucleotide binding] 691437008998 dimer interface [polypeptide binding]; other site 691437008999 mercury binding site [ion binding]; other site 691437009000 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 691437009001 metal-binding site [ion binding] 691437009002 mercuric reductase; Region: MerA; TIGR02053 691437009003 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 691437009004 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 691437009005 MerE protein; Region: MerE; cl04911 691437009006 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 691437009007 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3883 691437009008 Peptidase family M23; Region: Peptidase_M23; pfam01551 691437009009 Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177 691437009010 FtsX-like permease family; Region: FtsX; cl15850 691437009011 Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884 691437009012 FtsE is a hydrophilic nucleotide-binding protein that binds FtsX to form a heterodimeric ATP-binding cassette (ABC)-type transporter that associates with the bacterial inner membrane. The FtsE/X transporter is thought to be involved in cell division and...; Region: ABC_FtsE_transporter; cd03292 691437009013 Walker A/P-loop; other site 691437009014 ATP binding site [chemical binding]; other site 691437009015 Q-loop/lid; other site 691437009016 ABC transporter signature motif; other site 691437009017 Walker B; other site 691437009018 D-loop; other site 691437009019 H-loop/switch region; other site 691437009020 Cytochrome c; Region: Cytochrom_C; cl11414 691437009021 Uncharacterized conserved protein [Function unknown]; Region: COG1284 691437009022 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 691437009023 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 691437009024 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; cl10498 691437009025 Plasmid stabilisation system protein; Region: Plasmid_stabil; cl11422 691437009026 peptide chain release factor 2; Validated; Region: prfB; PRK00578 691437009027 RF-1 domain; Region: RF-1; cl02875 691437009028 RF-1 domain; Region: RF-1; cl02875 691437009029 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 691437009030 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 691437009031 SecA preprotein cross-linking domain; Region: SecA_PP_bind; cl03078 691437009032 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 691437009033 nucleotide binding region [chemical binding]; other site 691437009034 ATP-binding site [chemical binding]; other site 691437009035 Uncharacterized conserved protein (DUF2036); Region: DUF2036; pfam09724 691437009036 SEC-C motif; Region: SEC-C; pfam02810 691437009037 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 691437009038 RaiA ('ribosome-associated inhibitor A', also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal A site; Region: RaiA; cd00552 691437009039 30S subunit binding site; other site 691437009040 Flagellar protein FliT; Region: FliT; cl05125 691437009041 Flagellar protein FliS; Region: FliS; cl00654 691437009042 flagellar capping protein; Validated; Region: fliD; PRK07737 691437009043 Flagellar hook-associated protein 2 C-terminus; Region: FliD_N; pfam02465 691437009044 Flagellin hook IN motif; Region: Flagellin_IN; pfam07196 691437009045 Flagellar hook-associated protein 2 C-terminus; Region: FliD_C; pfam07195 691437009046 FlaG protein; Region: FlaG; cl00591 691437009047 LAGLIDADG DNA endonuclease family; Region: LAGLIDADG_2; pfam03161 691437009048 flagellin; Reviewed; Region: PRK08869 691437009049 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 691437009050 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 691437009051 Global regulator protein family; Region: CsrA; cl00670 691437009052 FliW protein; Region: FliW; cl00740 691437009053 flagellar hook-associated protein FlgL; Validated; Region: flgL; PRK07701 691437009054 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 691437009055 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 691437009056 flagellar hook-associated protein FlgK; Validated; Region: flgK; PRK07739 691437009057 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; cl15855 691437009058 FlgN protein; Region: FlgN; cl09176 691437009059 Anti-sigma-28 factor, FlgM; Region: FlgM; cl01052 691437009060 flagellar operon protein TIGR03826; Region: YvyF 691437009061 Protein of unknown function (DUF327); Region: DUF327; cl00753 691437009062 flagellin; Provisional; Region: PRK12804 691437009063 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 691437009064 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 691437009065 Flagellar protein FliS; Region: FliS; cl00654 691437009066 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257; cl15822 691437009067 Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040 691437009068 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 691437009069 active site 691437009070 Superfamily II DNA/RNA helicase required for DNA uptake (late competence protein) [DNA replication, recombination, and repair]; Region: comFA; COG4098 691437009071 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 691437009072 ATP binding site [chemical binding]; other site 691437009073 putative Mg++ binding site [ion binding]; other site 691437009074 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 691437009075 nucleotide binding region [chemical binding]; other site 691437009076 ATP-binding site [chemical binding]; other site 691437009077 Uncharacterized protein, DegV family COG1307; Region: DegV; cl00577 691437009078 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 691437009079 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 691437009080 active site 691437009081 phosphorylation site [posttranslational modification] 691437009082 intermolecular recognition site; other site 691437009083 dimerization interface [polypeptide binding]; other site 691437009084 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 691437009085 DNA binding residues [nucleotide binding] 691437009086 dimerization interface [polypeptide binding]; other site 691437009087 Sensor protein DegS; Region: DegS; pfam05384 691437009088 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 691437009089 Histidine kinase; Region: HisKA_3; pfam07730 691437009090 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 691437009091 ATP binding site [chemical binding]; other site 691437009092 Mg2+ binding site [ion binding]; other site 691437009093 G-X-G motif; other site 691437009094 uncharacterized protein, YigZ family; Region: IMPACT_YIGZ; TIGR00257 691437009095 Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205 691437009096 Domain of unknown function (DUF1949); Region: DUF1949; pfam09186 691437009097 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581 691437009098 Bacterial SH3 domain; Region: SH3_3; cl02551 691437009099 Bacterial SH3 domain; Region: SH3_3; cl02551 691437009100 Bacterial SH3 domain; Region: SH3_3; cl02551 691437009101 Bacterial SH3 domain; Region: SH3_3; cl02551 691437009102 Bacterial SH3 domain; Region: SH3_3; cl02551 691437009103 Bacterial SH3 domain; Region: SH3_3; cl02551 691437009104 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3807 691437009105 Bacterial SH3 domain; Region: SH3_3; cl02551 691437009106 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 691437009107 active site 691437009108 metal binding site [ion binding]; metal-binding site 691437009109 Bacterial SH3 domain; Region: SH3_3; cl02551 691437009110 Bacterial SH3 domain; Region: SH3_3; cl02551 691437009111 Stage II sporulation protein; Region: SpoIID; pfam08486 691437009112 SpoIID/LytB domain; Region: SpoIID_LytB; TIGR02669 691437009113 putative glycosyl transferase; Provisional; Region: PRK10307 691437009114 This family is most closely related to the GT1 family of glycosyltransferases. wbuB in E. coli is involved in the biosynthesis of the O26 O-antigen. It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase; Region: GT1_wbuB_like; cd03794 691437009115 This family is most closely related to the GT1 family of glycosyltransferases. wlbH in Bordetella parapertussis has been shown to be required for the biosynthesis of a trisaccharide that, when attached to the B. pertussis lipopolysaccharide (LPS) core; Region: GT1_wlbH_like; cd03798 691437009116 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 691437009117 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 691437009118 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 691437009119 active site 691437009120 UDP-N-acetylglucosamine 2-epimerase; Region: Epimerase_2; pfam02350 691437009121 homodimer interface [polypeptide binding]; other site 691437009122 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 691437009123 MatE; Region: MatE; cl10513 691437009124 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 691437009125 putative trimer interface [polypeptide binding]; other site 691437009126 Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110 691437009127 putative CoA binding site [chemical binding]; other site 691437009128 WcxM-like, Left-handed parallel beta-Helix (LbH) N-terminal domain: This group is composed of Xanthomonas campestris WcxM and proteins with similarity to the WcxM N-terminal domain. WcxM is thought to be bifunctional, catalyzing both the isomerization...; Region: LbH_WxcM_N_like; cd03358 691437009129 putative trimer interface [polypeptide binding]; other site 691437009130 putative active site [active] 691437009131 putative substrate binding site [chemical binding]; other site 691437009132 putative CoA binding site [chemical binding]; other site 691437009133 UDP-N-acetyl-D-mannosaminuronate dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: WecC; COG0677 691437009134 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 691437009135 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 691437009136 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 691437009137 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 691437009138 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; cl11611 691437009139 DegT/DnrJ/EryC1/StrS aminotransferase family; Region: DegT_DnrJ_EryC1; pfam01041 691437009140 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 691437009141 inhibitor-cofactor binding pocket; inhibition site 691437009142 pyridoxal 5'-phosphate binding site [chemical binding]; other site 691437009143 catalytic residue [active] 691437009144 UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472 691437009145 This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853 691437009146 Mg++ binding site [ion binding]; other site 691437009147 putative catalytic motif [active] 691437009148 substrate binding site [chemical binding]; other site 691437009149 preprotein translocase subunit SecA; Reviewed; Region: PRK09200 691437009150 SecA preprotein cross-linking domain; Region: SecA_PP_bind; cl03078 691437009151 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 691437009152 Protein of unknown function (DUF3426); Region: DUF3426; pfam11906 691437009153 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 691437009154 C-terminal peptidase (prc); Region: prc; TIGR00225 691437009155 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 691437009156 protein binding site [polypeptide binding]; other site 691437009157 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 691437009158 Catalytic dyad [active] 691437009159 Bacterial Ig-like domain; Region: Big_5; cl01012 691437009160 Predicted periplasmic protein (DUF2233); Region: DUF2233; pfam09992 691437009161 Predicted periplasmic protein (DUF2233); Region: DUF2233; pfam09992 691437009162 Flagellar filament outer layer protein Flaa; Region: FlaA; pfam04620 691437009163 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 691437009164 Early set domain associated with the catalytic domain of sugar utilizing enzymes at either the N or C terminus; Region: E_set; cl09101 691437009165 N-terminal Early set domain associated with the catalytic domain of cyclomaltodextrinase and pullulan-degrading enzymes; Region: E_set_CDase_PDE_N; cd02857 691437009166 homodimer interface [polypeptide binding]; other site 691437009167 maltodextrin glucosidase; Provisional; Region: PRK10785 691437009168 Alpha amylase catalytic domain found in cyclomaltodextrinases and related proteins; Region: AmyAc_CMD; cd11338 691437009169 active site 691437009170 homodimer interface [polypeptide binding]; other site 691437009171 catalytic site [active] 691437009172 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; cl02706 691437009173 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cl00065 691437009174 Domain of unknown function (DUF3416); Region: DUF3416; pfam11896 691437009175 The family 20 carbohydrate-binding module (CBM20), also known as the starch-binding domain, is found in a large number of starch degrading enzymes including alpha-amylase, beta-amylase, glucoamylase, and CGTase (cyclodextrin glucanotransferase). CBM20 is...; Region: CBM20; cl15347 691437009176 cytoplasmic alpha-amylase; Reviewed; Region: PRK09441 691437009177 Alpha amylase catalytic domain found in bacterial and fungal Alpha amylases (also called 1,4-alpha-D-glucan-4-glucanohydrolase); Region: AmyAc_bac_fung_AmyA; cd11318 691437009178 active site 691437009179 Na/Ca binding site [ion binding]; other site 691437009180 catalytic site [active] 691437009181 Domain of unknown function (DUF1939); Region: DUF1939; pfam09154 691437009182 bifunctional 2',3'-cyclic nucleotide 2'-phosphodiesterase/3'-nucleotidase periplasmic precursor protein; Reviewed; Region: cpdB; PRK09420 691437009183 Escherichia coli CpdB and related proteins, N-terminal metallophosphatase domain; Region: MPP_CpdB_N; cd07410 691437009184 active site 691437009185 metal binding site [ion binding]; metal-binding site 691437009186 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 691437009187 Domain of unknown function (DUF955); Region: DUF955; cl01076 691437009188 Putative peptidoglycan binding domain; Region: PG_binding_1; cl15437 691437009189 Putative peptidoglycan binding domain; Region: PG_binding_1; cl15437 691437009190 Putative peptidoglycan binding domain; Region: PG_binding_1; cl15437 691437009191 Putative peptidoglycan binding domain; Region: PG_binding_1; cl15437 691437009192 NlpC/P60 family; Region: NLPC_P60; cl11438 691437009193 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 691437009194 non-specific DNA binding site [nucleotide binding]; other site 691437009195 salt bridge; other site 691437009196 sequence-specific DNA binding site [nucleotide binding]; other site 691437009197 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 691437009198 dimer interface [polypeptide binding]; other site 691437009199 ssDNA binding site [nucleotide binding]; other site 691437009200 tetramer (dimer of dimers) interface [polypeptide binding]; other site 691437009201 YwpF-like protein; Region: YwpF; pfam14183 691437009202 Sortase D (SrtD) is a membrane transpeptidase found in gram-positive bacteria that anchors surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the surface protein substrate is cleaved...; Region: Sortase_D_4; cd05828 691437009203 active site 691437009204 catalytic site [active] 691437009205 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 691437009206 aspartate kinase; Reviewed; Region: PRK09034 691437009207 AAK_AKiii-YclM-BS: Amino Acid Kinase Superfamily (AAK), AKiii-YclM-BS; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine plus threonine-sensitive aspartokinase isoenzyme AKIII, a monofunctional class enzyme found in...; Region: AAK_AKiii-YclM-BS; cd04245 691437009208 putative catalytic residues [active] 691437009209 putative nucleotide binding site [chemical binding]; other site 691437009210 putative aspartate binding site [chemical binding]; other site 691437009211 ACT domains located C-terminal to the catalytic domain of the lysine plus threonine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-YclM-BS_1; cd04911 691437009212 allosteric regulatory residue; other site 691437009213 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 691437009214 Protein of unknown function (DUF1284); Region: DUF1284; cl01419 691437009215 Ralstonia eutrophus NAD+-dependent acetaldehyde dehydrogenase II-like; Region: ALDH_ACDHII-AcoD; cd07116 691437009216 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 691437009217 NAD(P) binding site [chemical binding]; other site 691437009218 catalytic residues [active] 691437009219 Protein of unknown function (DUF779); Region: DUF779; cl01432 691437009220 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 691437009221 Major Facilitator Superfamily; Region: MFS_1; pfam07690 691437009222 putative substrate translocation pore; other site 691437009223 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 691437009224 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 691437009225 Helix-turn-helix domains; Region: HTH; cl00088 691437009226 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 691437009227 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 691437009228 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 691437009229 dimer interface [polypeptide binding]; other site 691437009230 conserved gate region; other site 691437009231 putative PBP binding loops; other site 691437009232 ABC-ATPase subunit interface; other site 691437009233 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 691437009234 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 691437009235 dimer interface [polypeptide binding]; other site 691437009236 conserved gate region; other site 691437009237 putative PBP binding loops; other site 691437009238 ABC-ATPase subunit interface; other site 691437009239 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 691437009240 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 691437009241 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 691437009242 Response regulator containing CheY-like receiver domain and AraC-type DNA-binding domain [Signal transduction mechanisms]; Region: COG4753 691437009243 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 691437009244 active site 691437009245 phosphorylation site [posttranslational modification] 691437009246 intermolecular recognition site; other site 691437009247 dimerization interface [polypeptide binding]; other site 691437009248 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 691437009249 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 691437009250 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 691437009251 dimerization interface [polypeptide binding]; other site 691437009252 Histidine kinase; Region: His_kinase; pfam06580 691437009253 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 691437009254 ATP binding site [chemical binding]; other site 691437009255 Mg2+ binding site [ion binding]; other site 691437009256 G-X-G motif; other site 691437009257 Periplasmic sugar-binding domain of active transport systems that are members of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_sugar_binding_like; cd01536 691437009258 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 691437009259 ligand binding site [chemical binding]; other site 691437009260 Alpha-galactosidases/6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: CelF; COG1486 691437009261 Glycoside Hydrolases Family 4; Phospho-beta-glucosidase; Region: GH4_P_beta_glucosidase; cd05296 691437009262 NAD binding site [chemical binding]; other site 691437009263 sugar binding site [chemical binding]; other site 691437009264 divalent metal binding site [ion binding]; other site 691437009265 tetramer (dimer of dimers) interface [polypeptide binding]; other site 691437009266 dimer interface [polypeptide binding]; other site 691437009267 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 691437009268 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 691437009269 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 691437009270 putative active site [active] 691437009271 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 691437009272 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 691437009273 Walker A/P-loop; other site 691437009274 ATP binding site [chemical binding]; other site 691437009275 Q-loop/lid; other site 691437009276 ABC transporter signature motif; other site 691437009277 Walker B; other site 691437009278 D-loop; other site 691437009279 H-loop/switch region; other site 691437009280 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 691437009281 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 691437009282 FtsX-like permease family; Region: FtsX; cl15850 691437009283 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cd05709 691437009284 active site 691437009285 putative substrate binding region [chemical binding]; other site 691437009286 D-lactate dehydrogenase [cytochrome]; Region: PLN02805 691437009287 FAD binding domain; Region: FAD_binding_4; pfam01565 691437009288 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 691437009289 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 691437009290 alpha subunit interface [polypeptide binding]; other site 691437009291 TPP binding site [chemical binding]; other site 691437009292 heterodimer interface [polypeptide binding]; other site 691437009293 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 691437009294 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_x; TIGR03181 691437009295 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 691437009296 TPP-binding site [chemical binding]; other site 691437009297 tetramer interface [polypeptide binding]; other site 691437009298 heterodimer interface [polypeptide binding]; other site 691437009299 phosphorylation loop region [posttranslational modification] 691437009300 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 691437009301 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 691437009302 E3 interaction surface; other site 691437009303 lipoyl attachment site [posttranslational modification]; other site 691437009304 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; cl02008 691437009305 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 691437009306 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 691437009307 Domain of unknown function (DUF4275); Region: DUF4275; pfam14101 691437009308 Low molecular weight phosphatase family; Region: LMWPc; cd00115 691437009309 Low molecular weight phosphotyrosine protein phosphatase; Region: LMWPc; pfam01451 691437009310 active site 691437009311 Arsenite efflux pump ACR3 and related permeases [Inorganic ion transport and metabolism]; Region: ACR3; COG0798 691437009312 Membrane transport protein; Region: Mem_trans; cl09117 691437009313 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 691437009314 dimerization interface [polypeptide binding]; other site 691437009315 putative DNA binding site [nucleotide binding]; other site 691437009316 putative Zn2+ binding site [ion binding]; other site 691437009317 Protein of unknown function (DUF1360); Region: DUF1360; pfam07098 691437009318 Periplasmic sugar-binding domain of the thermophilic Thermoanaerobacter tengcongensis ribose binding protein (ttRBP) and its mesophilic homologs; Region: PBP1_ribose_binding; cd06323 691437009319 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 691437009320 ligand binding site [chemical binding]; other site 691437009321 dimerization interface [polypeptide binding]; other site 691437009322 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 691437009323 TM-ABC transporter signature motif; other site 691437009324 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 691437009325 This family represents the domain I of the carbohydrate uptake proteins that transport only monosaccharides (Monos). The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and hexoses...; Region: ABC_Carb_Monos_I; cd03216 691437009326 Walker A/P-loop; other site 691437009327 ATP binding site [chemical binding]; other site 691437009328 Q-loop/lid; other site 691437009329 ABC transporter signature motif; other site 691437009330 Walker B; other site 691437009331 D-loop; other site 691437009332 H-loop/switch region; other site 691437009333 This family represents domain II of the carbohydrate uptake proteins that transport only monosaccharides (Monos). The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and hexoses; Region: ABC_Carb_Monos_II; cd03215 691437009334 RbsD / FucU transport protein family; Region: RbsD_FucU; cl00809 691437009335 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 691437009336 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 691437009337 substrate binding site [chemical binding]; other site 691437009338 dimer interface [polypeptide binding]; other site 691437009339 ATP binding site [chemical binding]; other site 691437009340 Transcriptional regulators [Transcription]; Region: PurR; COG1609 691437009341 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 691437009342 DNA binding site [nucleotide binding] 691437009343 domain linker motif; other site 691437009344 Ligand binding domain of the lacI-like transcription regulator from a novel metal-reducing bacterium Alkaliphilus Metalliredigens (strain Qymf) and its close homologs; Region: PBP1_Qymf_like; cd06291 691437009345 dimerization interface [polypeptide binding]; other site 691437009346 ligand binding site [chemical binding]; other site 691437009347 sodium binding site [ion binding]; other site 691437009348 VanZ like family; Region: VanZ; cl01971 691437009349 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 691437009350 M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886 691437009351 metal binding site [ion binding]; metal-binding site 691437009352 dimer interface [polypeptide binding]; other site 691437009353 Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004 691437009354 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 691437009355 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 691437009356 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 691437009357 Bacterial SH3 domain; Region: SH3_3; cl02551 691437009358 Bacterial SH3 domain; Region: SH3_3; cl02551 691437009359 Bacterial SH3 domain; Region: SH3_3; cl02551 691437009360 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 691437009361 active site 691437009362 metal binding site [ion binding]; metal-binding site 691437009363 SEC-C motif; Region: SEC-C; pfam02810 691437009364 Plasmid pRiA4b ORF-3-like protein; Region: PRiA4_ORF3; pfam07929 691437009365 SEC-C motif; Region: SEC-C; pfam02810 691437009366 SEC-C motif; Region: SEC-C; pfam02810 691437009367 SEC-C motif; Region: SEC-C; pfam02810 691437009368 Uncharacterized conserved protein [Function unknown]; Region: COG4715 691437009369 SNF2 Helicase protein; Region: DUF3670; pfam12419 691437009370 SNF2 family N-terminal domain; Region: SNF2_N; pfam00176 691437009371 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 691437009372 ATP binding site [chemical binding]; other site 691437009373 putative Mg++ binding site [ion binding]; other site 691437009374 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 691437009375 nucleotide binding region [chemical binding]; other site 691437009376 ATP-binding site [chemical binding]; other site 691437009377 Protein of unknown function (DUF1861); Region: DUF1861; pfam08950 691437009378 Macro domain, Unknown family 2. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ADP-ribose polymerases)...; Region: Macro_2; cd03330 691437009379 putative ADP-ribose binding site [chemical binding]; other site 691437009380 AAA domain; Region: AAA_21; pfam13304 691437009381 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 691437009382 active site 691437009383 tetramer interface; other site 691437009384 Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647 691437009385 active site 691437009386 Protein of unknown function (DUF1861); Region: DUF1861; pfam08950 691437009387 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 691437009388 dimer interface [polypeptide binding]; other site 691437009389 conserved gate region; other site 691437009390 ABC-ATPase subunit interface; other site 691437009391 EamA-like transporter family; Region: EamA; cl01037 691437009392 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 691437009393 EamA-like transporter family; Region: EamA; cl01037 691437009394 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118 691437009395 putative peptidoglycan binding site; other site 691437009396 L,D-transpeptidase catalytic domain; Region: YkuD; cl15405 691437009397 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 691437009398 D-galactonate transporter; Region: 2A0114; TIGR00893 691437009399 putative substrate translocation pore; other site 691437009400 Protein of unknown function DUF262; Region: DUF262; cl14890 691437009401 Protein of unknown function DUF262; Region: DUF262; cl14890 691437009402 bifunctional argininosuccinate lyase/N-acetylglutamate synthase; Provisional; Region: PRK12308 691437009403 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 691437009404 Coenzyme A binding pocket [chemical binding]; other site 691437009405 aminotransferase, LLPSF_NHT_00031 family; Region: NHT_00031; TIGR04181 691437009406 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 691437009407 inhibitor-cofactor binding pocket; inhibition site 691437009408 pyridoxal 5'-phosphate binding site [chemical binding]; other site 691437009409 catalytic residue [active] 691437009410 sugar O-acyltransferase, sialic acid O-acetyltransferase NeuD family; Region: NeuD_NnaD; TIGR03570 691437009411 Putative Acyltransferase (AT), Left-handed parallel beta-Helix (LbH) domain; This group is composed of mostly uncharacterized proteins containing an N-terminal helical subdomain followed by a LbH domain. The alignment contains 6 turns, each containing...; Region: LbH_AT_putative; cd03360 691437009412 putative trimer interface [polypeptide binding]; other site 691437009413 putative CoA binding site [chemical binding]; other site 691437009414 Bacterial sugar transferase; Region: Bac_transf; cl00939 691437009415 UDP-glucose 4-epimerase; Region: PLN02240 691437009416 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 691437009417 NAD binding site [chemical binding]; other site 691437009418 homodimer interface [polypeptide binding]; other site 691437009419 active site 691437009420 substrate binding site [chemical binding]; other site 691437009421 Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004 691437009422 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 691437009423 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 691437009424 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 691437009425 UDP glucuronic acid epimerase, extended (e) SDRs; Region: UDP_GE_SDE_e; cd05253 691437009426 putative NAD(P) binding site [chemical binding]; other site 691437009427 active site 691437009428 putative substrate binding site [chemical binding]; other site 691437009429 This family is most closely related to the GT1 family of glycosyltransferases. cap1E in Streptococcus pneumoniae is required for the synthesis of type 1 capsular polysaccharides; Region: GT1_cap1E_like; cd03808 691437009430 N-acetyl-alpha-D-glucosaminyl L-malate synthase BshA; Region: thiol_BshA; TIGR03999 691437009431 putative ADP-binding pocket [chemical binding]; other site 691437009432 This family is most closely related to the GT1 family of glycosyltransferases. WbnK in Shigella dysenteriae has been shown to be involved in the type 7 O-antigen biosynthesis; Region: GT1_WbnK_like; cd03807 691437009433 sugar transferase, PEP-CTERM/EpsH1 system associated; Region: stp2; TIGR03088 691437009434 putative ADP-binding pocket [chemical binding]; other site 691437009435 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 691437009436 This family is most closely related to the GT1 family of glycosyltransferases. WabH in Klebsiella pneumoniae has been shown to transfer a GlcNAc residue from UDP-GlcNAc onto the acceptor GalUA residue in the cellular outer core; Region: GT1_WabH_like; cd03811 691437009437 putative ADP-binding pocket [chemical binding]; other site 691437009438 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 691437009439 MatE; Region: MatE; cl10513 691437009440 Bacterial sugar transferase; Region: Bac_transf; cl00939 691437009441 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 691437009442 active site 691437009443 tetramer interface; other site 691437009444 Predicted membrane protein [Function unknown]; Region: COG1511 691437009445 Uncharacterized conserved protein [Function unknown]; Region: COG4938 691437009446 Capsular polysaccharide biosynthesis protein [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: CapC; COG4464 691437009447 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581 691437009448 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229 691437009449 active site 691437009450 oxyanion hole [active] 691437009451 catalytic triad [active] 691437009452 capsular exopolysaccharide family; Region: eps_fam; TIGR01007 691437009453 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 691437009454 Capsular polysaccharide biosynthesis protein [Cell envelope biogenesis, outer membrane]; Region: COG3944 691437009455 Chain length determinant protein; Region: Wzz; cl15801 691437009456 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 691437009457 DNA-directed RNA polymerase subunit beta; Region: EpuA; pfam11772 691437009458 Flagellar basal body rod protein [Cell motility and secretion]; Region: FlgG; COG4786 691437009459 Flagella basal body rod protein; Region: Flg_bb_rod; cl15793 691437009460 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; cl15855 691437009461 Flagellar basal body rod protein [Cell motility and secretion]; Region: FlgG; COG4786 691437009462 Flagella basal body rod protein; Region: Flg_bb_rod; cl15793 691437009463 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; cl15855 691437009464 rod shape-determining protein Mbl; Provisional; Region: PRK13928 691437009465 Actin; An ubiquitous protein involved in the formation of filaments that are a major component of the cytoskeleton. Interaction with myosin provides the basis of muscular contraction and many aspects of cell motility. Each actin protomer binds one...; Region: ACTIN; cl11528 691437009466 ATP binding site [chemical binding]; other site 691437009467 profilin binding site; other site 691437009468 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 691437009469 Intracellular proteinase inhibitor; Region: BsuPI; pfam12690 691437009470 Chromate transporter; Region: Chromate_transp; pfam02417 691437009471 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; cl08040 691437009472 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019 691437009473 Peptidase family M23; Region: Peptidase_M23; pfam01551 691437009474 Apocytochrome F, C-terminal; Region: Apocytochr_F_C; cl03168 691437009475 stage II sporulation protein D; Region: spore_II_D; TIGR02870 691437009476 Stage II sporulation protein; Region: SpoIID; pfam08486 691437009477 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 691437009478 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 691437009479 hinge; other site 691437009480 active site 691437009481 Protein of unknown function (DUF1779); Region: DUF1779; pfam08680 691437009482 Protein of unknown function (DUF1146); Region: DUF1146; cl11486 691437009483 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; cl14187 691437009484 NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846 691437009485 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; cl14187 691437009486 NADH:ubiquinone oxidoreductase subunit L; Reviewed; Region: PRK06590 691437009487 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; cl14187 691437009488 NADH-ubiquinone/plastoquinone oxidoreductase chain 4L; Region: Oxidored_q2; cl00492 691437009489 NADH:ubiquinone oxidoreductase subunit J; Provisional; Region: PRK06638 691437009490 NADH dehydrogenase subunit J; Provisional; Region: PRK06433; cl14634 691437009491 NADH dehydrogenase subunit I; Provisional; Region: PRK05888 691437009492 4Fe-4S binding domain; Region: Fer4; cl02805 691437009493 4Fe-4S binding domain; Region: Fer4; cl02805 691437009494 NADH dehydrogenase; Region: NADHdh; cl00469 691437009495 Nickel-dependent hydrogenase; Region: NiFeSe_Hases; cl00417 691437009496 Respiratory-chain NADH dehydrogenase, 49 Kd subunit; Region: Complex1_49kDa; pfam00346 691437009497 Respiratory-chain NADH dehydrogenase, 30 Kd subunit; Region: Complex1_30kDa; cl15771 691437009498 NADH dehydrogenase subunit B; Validated; Region: PRK06411 691437009499 NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; cl15792 691437009500 NADH-ubiquinone/plastoquinone oxidoreductase, chain 3; Region: Oxidored_q4; cl00535 691437009501 F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571 691437009502 ATP synthase, Delta/Epsilon chain, beta-sandwich domain; Region: ATP-synt_DE_N; cl10033 691437009503 ATP synthase, Delta/Epsilon chain, long alpha-helix domain; Region: ATP-synt_DE; pfam00401 691437009504 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 691437009505 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; cl15275 691437009506 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 691437009507 alpha subunit interaction interface [polypeptide binding]; other site 691437009508 Walker A motif; other site 691437009509 ATP binding site [chemical binding]; other site 691437009510 Walker B motif; other site 691437009511 inhibitor binding site; inhibition site 691437009512 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 691437009513 ATP synthase; Region: ATP-synt; cl00365 691437009514 F0F1 ATP synthase subunit gamma; Provisional; Region: PRK13422 691437009515 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 691437009516 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; cl15275 691437009517 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 691437009518 beta subunit interaction interface [polypeptide binding]; other site 691437009519 Walker A motif; other site 691437009520 ATP binding site [chemical binding]; other site 691437009521 Walker B motif; other site 691437009522 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 691437009523 Plant ATP synthase F0; Region: YMF19; cl07975 691437009524 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 691437009525 Plant ATP synthase F0; Region: YMF19; cl07975 691437009526 ATP synthase subunit C; Region: ATP-synt_C; cl00466 691437009527 ATP synthase A chain; Region: ATP-synt_A; cl00413 691437009528 ATP synthase I chain; Region: ATP_synt_I; cl09170 691437009529 Putative F0F1-ATPase subunit (ATPase_gene1); Region: ATPase_gene1; cl09754 691437009530 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 691437009531 active site 691437009532 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 691437009533 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 691437009534 dimer interface [polypeptide binding]; other site 691437009535 active site 691437009536 glycine-pyridoxal phosphate binding site [chemical binding]; other site 691437009537 folate binding site [chemical binding]; other site 691437009538 Protein of unknown function (DUF436); Region: DUF436; cl01860 691437009539 Ribose/Galactose Isomerase; Region: LacAB_rpiB; cl00485 691437009540 Signal transduction histidine kinase involved in nitrogen fixation and metabolism regulation [Signal transduction mechanisms]; Region: NtrY; COG5000 691437009541 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 691437009542 dimerization interface [polypeptide binding]; other site 691437009543 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 691437009544 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 691437009545 dimer interface [polypeptide binding]; other site 691437009546 putative CheW interface [polypeptide binding]; other site 691437009547 Low molecular weight phosphatase family; Region: LMWPc; cd00115 691437009548 Low molecular weight phosphotyrosine protein phosphatase; Region: LMWPc; pfam01451 691437009549 active site 691437009550 Predicted membrane protein [Function unknown]; Region: COG1971 691437009551 Domain of unknown function DUF; Region: DUF204; pfam02659 691437009552 Domain of unknown function DUF; Region: DUF204; pfam02659 691437009553 Telomere recombination; Region: Sua5_yciO_yrdC; cl00305 691437009554 Putative GTP-binding controlling metal-binding; Region: SUA5; pfam03481 691437009555 Stage II sporulation protein R (spore_II_R); Region: Spore_II_R; cl09775 691437009556 protein-(glutamine-N5) methyltransferase, release factor-specific; Region: RF_mod_PrmC; TIGR03534 691437009557 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 691437009558 S-adenosylmethionine binding site [chemical binding]; other site 691437009559 peptide chain release factor 1; Validated; Region: prfA; PRK00591 691437009560 RF-1 domain; Region: RF-1; cl02875 691437009561 RF-1 domain; Region: RF-1; cl02875 691437009562 D-fructose-responsive transcription factor; Region: fruct_sucro_rep; TIGR02417 691437009563 thymidine kinase; Provisional; Region: PRK04296 691437009564 SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339 691437009565 Ribosomal protein L31; Region: Ribosomal_L31; cl00377 691437009566 transcription termination factor Rho; Provisional; Region: rho; PRK09376 691437009567 Rho termination factor, N-terminal domain; Region: Rho_N; cl06505 691437009568 Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459 691437009569 RNA binding site [nucleotide binding]; other site 691437009570 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128 691437009571 multimer interface [polypeptide binding]; other site 691437009572 Walker A motif; other site 691437009573 ATP binding site [chemical binding]; other site 691437009574 Walker B motif; other site 691437009575 Bacterial fructose-1,6-bisphosphatase, glpX-encoded. A dimeric enzyme dependent on Mg(2+). glpX-encoded FPBase (FBPase class II) differs from other members of the inositol-phosphatase superfamily by permutation of secondary structure elements. The core...; Region: FBPase_glpX; cd01516 691437009576 putative active site [active] 691437009577 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 691437009578 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 691437009579 hinge; other site 691437009580 active site 691437009581 Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956 691437009582 active site 691437009583 intersubunit interactions; other site 691437009584 catalytic residue [active] 691437009585 hypothetical protein; Provisional; Region: PRK08185 691437009586 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 691437009587 intersubunit interface [polypeptide binding]; other site 691437009588 active site 691437009589 zinc binding site [ion binding]; other site 691437009590 Na+ binding site [ion binding]; other site 691437009591 Response regulator receiver domain; Region: Response_reg; pfam00072 691437009592 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 691437009593 active site 691437009594 phosphorylation site [posttranslational modification] 691437009595 intermolecular recognition site; other site 691437009596 dimerization interface [polypeptide binding]; other site 691437009597 Protein of unknown function (DUF2529); Region: DUF2529; pfam10740 691437009598 CTP synthetase; Validated; Region: pyrG; PRK05380 691437009599 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 691437009600 Catalytic site [active] 691437009601 active site 691437009602 UTP binding site [chemical binding]; other site 691437009603 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 691437009604 active site 691437009605 putative oxyanion hole; other site 691437009606 catalytic triad [active] 691437009607 DNA-directed RNA polymerase delta subunit; Region: RNA_pol_delta; cl01319 691437009608 methylmalonyl CoA mutase B12 binding domain. This domain binds to B12 (adenosylcobamide), which initiates the conversion of succinyl CoA and methylmalonyl CoA by forming an adenosyl radical, which then undergoes a rearrangement exchanging a hydrogen atom...; Region: MM_CoA_mut_B12_BD; cd02071 691437009609 B12 binding site [chemical binding]; other site 691437009610 cobalt ligand [ion binding]; other site 691437009611 Putative periplasmic protein kinase ArgK and related GTPases of G3E family [Amino acid transport and metabolism]; Region: ArgK; COG1703 691437009612 The function of this protein family is unkown. The protein sequences are similar to the ArgK protein in E. coli. ArgK protein is a membrane ATPase which is required for transporting arginine, ornithine and lysine into the cells by the arginine and...; Region: ArgK-like; cd03114 691437009613 Walker A; other site 691437009614 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM) family, unknown subfamily 1; composed of uncharacterized bacterial proteins containing a C-terminal MCM domain. MCM catalyzes the isomerization of methylmalonyl-CoA to succinyl-CoA. The...; Region: MM_CoA_mutase_1; cd03678 691437009615 Methylmalonyl-CoA mutase, N-terminal domain/subunit [Lipid metabolism]; Region: Sbm; COG1884 691437009616 putative active site [active] 691437009617 putative substrate binding site [chemical binding]; other site 691437009618 putative coenzyme B12 binding site [chemical binding]; other site 691437009619 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 691437009620 Helix-turn-helix domains; Region: HTH; cl00088 691437009621 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 691437009622 Short chain acyl-CoA dehydrogenases and eukaryotic short/branched chain acyl-CoA dehydrogenases; Region: SCAD_SBCAD; cd01158 691437009623 FAD binding site [chemical binding]; other site 691437009624 homotetramer interface [polypeptide binding]; other site 691437009625 substrate binding pocket [chemical binding]; other site 691437009626 catalytic base [active] 691437009627 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 691437009628 Short chain acyl-CoA dehydrogenases and eukaryotic short/branched chain acyl-CoA dehydrogenases; Region: SCAD_SBCAD; cd01158 691437009629 FAD binding site [chemical binding]; other site 691437009630 homotetramer interface [polypeptide binding]; other site 691437009631 substrate binding pocket [chemical binding]; other site 691437009632 catalytic base [active] 691437009633 3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK05808 691437009634 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 691437009635 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 691437009636 acetyl-CoA acetyltransferase; Provisional; Region: PRK08235 691437009637 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 691437009638 dimer interface [polypeptide binding]; other site 691437009639 active site 691437009640 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 691437009641 Cysteine-rich domain; Region: CCG; pfam02754 691437009642 Cysteine-rich domain; Region: CCG; pfam02754 691437009643 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 691437009644 PLD-like domain; Region: PLDc_2; pfam13091 691437009645 putative active site [active] 691437009646 catalytic site [active] 691437009647 catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112 691437009648 PLD-like domain; Region: PLDc_2; pfam13091 691437009649 putative active site [active] 691437009650 catalytic site [active] 691437009651 arginyl-tRNA synthetase; Reviewed; Region: argS; PRK01611 691437009652 Arginyl tRNA synthetase N terminal domain; Region: Arg_tRNA_synt_N; cl04104 691437009653 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 691437009654 active site 691437009655 HIGH motif; other site 691437009656 KMSK motif region; other site 691437009657 Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956 691437009658 tRNA binding surface [nucleotide binding]; other site 691437009659 anticodon binding site; other site 691437009660 Domain of unknown function (DUF1934); Region: DUF1934; cl01870 691437009661 Heme-copper oxidase subunit I. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which catalyze the reduction of O2 and simultaneously pump protons across the membrane. The superfamily is...; Region: Heme_Cu_Oxidase_I; cl00275 691437009662 Arginase family; Region: Arginase; cl00306 691437009663 spermidine synthase; Provisional; Region: PRK00811 691437009664 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl15754 691437009665 Transglycosylase; Region: Transgly; cl07896 691437009666 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 691437009667 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 691437009668 YwhD family; Region: YwhD; pfam08741 691437009669 Uncharacterized homologs of Site-2 protease (S2P), zinc metalloproteases (MEROPS family M50) which cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of the...; Region: S2P-M50_like_1; cd06158 691437009670 active site 691437009671 putative substrate binding region [chemical binding]; other site 691437009672 4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cd00491 691437009673 active site 1 [active] 691437009674 dimer interface [polypeptide binding]; other site 691437009675 hexamer interface [polypeptide binding]; other site 691437009676 active site 2 [active] 691437009677 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 691437009678 Uncharacterized conserved protein [Function unknown]; Region: COG3465 691437009679 HD superfamily phosphohydrolases [General function prediction only]; Region: COG1078 691437009680 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 691437009681 Protein of unknown function (DUF1450); Region: DUF1450; cl11488 691437009682 putative spore coat protein regulator protein YlbO; Provisional; Region: PRK13923 691437009683 transcription factor, RsfA family; Region: DNA_bind_RsfA; TIGR02894 691437009684 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 691437009685 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 691437009686 Phosphate acetyl/butaryl transferase; Region: PTA_PTB; cl00390 691437009687 Phosphotransacetylase [Energy production and conversion]; Region: Pta; COG0280 691437009688 Chlorite dismutase; Region: Chlor_dismutase; cl01280 691437009689 Cell Wall Hydrolase; Region: Hydrolase_2; pfam07486 691437009690 Spore coat protein (Spore_GerQ); Region: Spore_GerQ; cl09881 691437009691 Protein of unknown function (DUF423); Region: DUF423; cl01008 691437009692 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 691437009693 ligand binding site [chemical binding]; other site 691437009694 active site 691437009695 UGI interface [polypeptide binding]; other site 691437009696 catalytic site [active] 691437009697 Protein of unknown function (DUF1232); Region: DUF1232; cl01318 691437009698 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 691437009699 anti sigma factor interaction site; other site 691437009700 regulatory phosphorylation site [posttranslational modification]; other site 691437009701 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 691437009702 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 691437009703 ATP binding site [chemical binding]; other site 691437009704 Mg2+ binding site [ion binding]; other site 691437009705 G-X-G motif; other site 691437009706 RNA polymerase sigma-70 factor, sigma-B/F/G subfamily; Region: SigBFG; TIGR02980 691437009707 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 691437009708 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 691437009709 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 691437009710 DNA binding residues [nucleotide binding] 691437009711 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 691437009712 PAS domain; Region: PAS_9; pfam13426 691437009713 putative active site [active] 691437009714 heme pocket [chemical binding]; other site 691437009715 Sigma factor PP2C-like phosphatases; Region: PP2C_SIG; smart00331 691437009716 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cl00120 691437009717 PemK-like protein; Region: PemK; cl00995 691437009718 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 691437009719 glycyl-tRNA synthetase; Provisional; Region: PRK04173 691437009720 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it attaches...; Region: class_II_aaRS-like_core; cl00268 691437009721 motif 1; other site 691437009722 Glycyl-tRNA synthetase (GlyRS)-like class II core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes. It is responsible for the attachment of glycine to the 3'...; Region: GlyRS-like_core; cd00774 691437009723 active site 691437009724 motif 2; other site 691437009725 motif 3; other site 691437009726 GlyRS Glycyl-anticodon binding domain. GlyRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: GlyRS_anticodon; cd00858 691437009727 anticodon binding site; other site 691437009728 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 691437009729 active site 691437009730 benzoate transport; Region: 2A0115; TIGR00895 691437009731 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 691437009732 putative substrate translocation pore; other site 691437009733 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 691437009734 Helix-turn-helix domains; Region: HTH; cl00088 691437009735 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cl00162 691437009736 HPr interaction site; other site 691437009737 glycerol kinase (GK) interaction site [polypeptide binding]; other site 691437009738 active site 691437009739 phosphorylation site [posttranslational modification] 691437009740 Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508 691437009741 Helix-turn-helix domains; Region: HTH; cl00088 691437009742 Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686 691437009743 Alanine dehydrogenase/PNT, N-terminal domain; Region: AlaDh_PNT_N; cl15379 691437009744 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 691437009745 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 691437009746 putative active site [active] 691437009747 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 691437009748 dimer interface [polypeptide binding]; other site 691437009749 substrate binding site [chemical binding]; other site 691437009750 ATP binding site [chemical binding]; other site 691437009751 Predicted amidohydrolase [General function prediction only]; Region: COG0388 691437009752 Uncharacterized subgroup of the nitrilase superfamily; some members of this subgroup have an N-terminal RimI domain (class 12 nitrilases); Region: nitrilase_Rim1_like; cd07574 691437009753 putative active site [active] 691437009754 catalytic triad [active] 691437009755 putative dimer interface [polypeptide binding]; other site 691437009756 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 691437009757 Sodium:solute symporter family; Region: SSF; cl00456 691437009758 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 691437009759 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 691437009760 substrate binding pocket [chemical binding]; other site 691437009761 membrane-bound complex binding site; other site 691437009762 hinge residues; other site 691437009763 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 691437009764 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 691437009765 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 691437009766 dimer interface [polypeptide binding]; other site 691437009767 conserved gate region; other site 691437009768 putative PBP binding loops; other site 691437009769 ABC-ATPase subunit interface; other site 691437009770 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 691437009771 HisP and GlnQ are the ATP-binding components of the bacterial periplasmic histidine and glutamine permeases, repectively. Histidine permease is a multisubunit complex containing the HisQ and HisM integral membrane subunits and two copies of HisP. HisP...; Region: ABC_HisP_GlnQ_permeases; cd03262 691437009772 Walker A/P-loop; other site 691437009773 ATP binding site [chemical binding]; other site 691437009774 Q-loop/lid; other site 691437009775 ABC transporter signature motif; other site 691437009776 Walker B; other site 691437009777 D-loop; other site 691437009778 H-loop/switch region; other site 691437009779 Probable transposase; Region: OrfB_IS605; pfam01385 691437009780 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 691437009781 Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282 691437009782 Transposase IS200 like; Region: Y1_Tnp; cl00848 691437009783 Prokaryotic Cytochrome C oxidase subunit IV; Region: COX4_pro; cl01204 691437009784 Ubiquinol oxidase subunit III subfamily. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously...; Region: Ubiquinol_oxidase_III; cd02863 691437009785 Subunit I/III interface [polypeptide binding]; other site 691437009786 Subunit III/IV interface [polypeptide binding]; other site 691437009787 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 691437009788 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 691437009789 D-pathway; other site 691437009790 Putative ubiquinol binding site [chemical binding]; other site 691437009791 Low-spin heme (heme b) binding site [chemical binding]; other site 691437009792 Putative water exit pathway; other site 691437009793 Binuclear center (heme o3/CuB) [ion binding]; other site 691437009794 K-pathway; other site 691437009795 Putative proton exit pathway; other site 691437009796 cytochrome aa3 quinol oxidase, subunit II; Region: QOXA; TIGR01432 691437009797 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; cl11412 691437009798 SpoU rRNA Methylase family; Region: SpoU_methylase; cl00362 691437009799 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 691437009800 Predicted transcriptional regulator containing an HTH domain and an uncharacterized domain shared with the mammalian protein Schlafen [Transcription]; Region: COG2865 691437009801 ATP-dependent DNA helicase recG C-terminal; Region: HATPase_c_4; pfam13749 691437009802 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 691437009803 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 691437009804 YhfW family, C-terminal Rieske domain; YhfW is a protein of unknown function with an N-terminal DadA-like (glycine/D-amino acid dehydrogenase) domain and a C-terminal Rieske domain. The Rieske domain is a [2Fe-2S] cluster binding domain involved in...; Region: Rieske_YhfW_C; cd03477 691437009805 [2Fe-2S] cluster binding site [ion binding]; other site 691437009806 Phosphomannose isomerase [Carbohydrate transport and metabolism]; Region: ManA; COG1482 691437009807 Phosphomannose isomerase type I; Region: PMI_typeI; cl15429 691437009808 Glycerate kinase family; Region: Gly_kinase; cl00841 691437009809 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 691437009810 metal binding site [ion binding]; metal-binding site 691437009811 active site 691437009812 I-site; other site 691437009813 Predicted SPOUT methyltransferase; Region: SPOUT_MTase; pfam02590 691437009814 Uncharacterized conserved protein [Function unknown]; Region: COG1576; cl00679 691437009815 YyzF-like protein; Region: YyzF; cl15733 691437009816 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149 691437009817 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 691437009818 protein binding site [polypeptide binding]; other site 691437009819 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 691437009820 YycH protein; Region: YycI; cl02015 691437009821 YycH protein; Region: YycH; pfam07435 691437009822 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4863 691437009823 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: VicK; COG5002 691437009824 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 691437009825 dimerization interface [polypeptide binding]; other site 691437009826 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 691437009827 putative active site [active] 691437009828 heme pocket [chemical binding]; other site 691437009829 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 691437009830 dimer interface [polypeptide binding]; other site 691437009831 phosphorylation site [posttranslational modification] 691437009832 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 691437009833 ATP binding site [chemical binding]; other site 691437009834 Mg2+ binding site [ion binding]; other site 691437009835 G-X-G motif; other site 691437009836 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 691437009837 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 691437009838 active site 691437009839 phosphorylation site [posttranslational modification] 691437009840 intermolecular recognition site; other site 691437009841 dimerization interface [polypeptide binding]; other site 691437009842 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 691437009843 DNA binding site [nucleotide binding] 691437009844 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 691437009845 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 691437009846 GDP-binding site [chemical binding]; other site 691437009847 ACT binding site; other site 691437009848 IMP binding site; other site 691437009849 replicative DNA helicase; Provisional; Region: PRK05748 691437009850 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 691437009851 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 691437009852 Walker A motif; other site 691437009853 ATP binding site [chemical binding]; other site 691437009854 Walker B motif; other site 691437009855 DNA binding loops [nucleotide binding] 691437009856 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 691437009857 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 691437009858 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 691437009859 Predicted signaling protein consisting of a modified GGDEF domain and a DHH domain [Signal transduction mechanisms]; Region: COG3887 691437009860 Class III nucleotidyl cyclases; Region: Nucleotidyl_cyc_III; cl11967 691437009861 DHH family; Region: DHH; pfam01368 691437009862 DHHA1 domain; Region: DHHA1; pfam02272 691437009863 Predicted membrane protein (DUF2232); Region: DUF2232; cl01728 691437009864 Ribosomal protein S18; Region: Ribosomal_S18; cl00373 691437009865 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 691437009866 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 691437009867 dimer interface [polypeptide binding]; other site 691437009868 ssDNA binding site [nucleotide binding]; other site 691437009869 tetramer (dimer of dimers) interface [polypeptide binding]; other site 691437009870 Ribosomal protein S6; Region: Ribosomal_S6; cl00414 691437009871 GTP-binding protein YchF; Reviewed; Region: PRK09601 691437009872 YchF GTPase; Region: YchF; cd01900 691437009873 G1 box; other site 691437009874 GTP/Mg2+ binding site [chemical binding]; other site 691437009875 Switch I region; other site 691437009876 G2 box; other site 691437009877 Switch II region; other site 691437009878 G3 box; other site 691437009879 G4 box; other site 691437009880 G5 box; other site 691437009881 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 691437009882 Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243 691437009883 The MopB_3 CD includes a group of related uncharacterized bacterial and archaeal molybdopterin-binding oxidoreductase-like domains with a putative N-terminal iron-sulfur [4Fe-4S] cluster binding site and molybdopterin cofactor binding site. These members...; Region: MopB_3; cd02766 691437009884 putative [4Fe-4S] binding site [ion binding]; other site 691437009885 putative molybdopterin cofactor binding site [chemical binding]; other site 691437009886 Molybdopterin-Binding, C-terminal (MopB_CT) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum-...; Region: MopB_CT; cl09929 691437009887 molybdopterin cofactor binding site; other site 691437009888 Bacterial protein of unknown function (DUF951); Region: DUF951; cl01864 691437009889 Mechanosensitive ion channel; Region: MS_channel; pfam00924 691437009890 Protein of unknown function (DUF1256); Region: DUF1256; cl06087 691437009891 ParB-like partition proteins; Region: parB_part; TIGR00180 691437009892 ParB-like nuclease domain; Region: ParBc; cl02129 691437009893 KorB domain; Region: KorB; pfam08535 691437009894 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 691437009895 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 691437009896 P-loop; other site 691437009897 Magnesium ion binding site [ion binding]; other site 691437009898 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 691437009899 Magnesium ion binding site [ion binding]; other site 691437009900 Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475 691437009901 ParB-like nuclease domain; Region: ParBc; cl02129 691437009902 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl15754 691437009903 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 691437009904 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 691437009905 GidA associated domain 3; Region: GIDA_assoc_3; pfam13932 691437009906 tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291 691437009907 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 691437009908 trmE is a tRNA modification GTPase; Region: trmE; cd04164 691437009909 G1 box; other site 691437009910 GTP/Mg2+ binding site [chemical binding]; other site 691437009911 Switch I region; other site 691437009912 G2 box; other site 691437009913 Switch II region; other site 691437009914 G3 box; other site 691437009915 G4 box; other site 691437009916 G5 box; other site 691437009917 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 691437009918 Predicted RNA-binding protein [General function prediction only]; Region: Jag; COG1847 691437009919 jag_K homology RNA-binding domain. The KH domain is found in proteins homologous to the Bacillus subtilis protein Jag, which is associated with SpoIIIJ and is necessary for the third stage of sporulation. The KH motif is a beta-alpha-alpha-beta-beta...; Region: jag_KH; cd02414 691437009920 G-X-X-G motif; other site 691437009921 R3H domain found in proteins homologous to Bacillus subtilus Jag, which is associated with SpoIIIJ. SpoIIIJ is necessary for the third stage of sporulation. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine...; Region: R3H_jag; cd02644 691437009922 RxxxH motif; other site 691437009923 60Kd inner membrane protein; Region: 60KD_IMP; cl00489 691437009924 Ribonuclease P; Region: Ribonuclease_P; cl00457 691437009925 Ribosomal protein L34; Region: Ribosomal_L34; cl00370