-- dump date 20120504_145103 -- class Genbank::misc_feature -- table misc_feature_note -- id note 471223000001 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 471223000002 DNA binding site [nucleotide binding] 471223000003 Int/Topo IB signature motif; other site 471223000004 active site 471223000005 C-5 cytosine-specific DNA methylase; Region: DNA_methylase; pfam00145 471223000006 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl15754 471223000007 cofactor binding site; other site 471223000008 DNA binding site [nucleotide binding] 471223000009 substrate interaction site [chemical binding]; other site 471223000010 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl15754 471223000011 MjaII restriction endonuclease; Region: RE_MjaII; pfam09520 471223000012 LEM domain; Region: LEM; cl02649 471223000013 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 471223000014 DNA binding residues [nucleotide binding] 471223000015 chromosomal replication initiation protein; Reviewed; Region: dnaA; PRK00149 471223000016 DnaA N-terminal domain; Region: DnaA_N; pfam11638 471223000017 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 471223000018 Walker A motif; other site 471223000019 ATP binding site [chemical binding]; other site 471223000020 Walker B motif; other site 471223000021 arginine finger; other site 471223000022 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 471223000023 DnaA box-binding interface [nucleotide binding]; other site 471223000024 DNA polymerase III subunit beta; Validated; Region: PRK05643 471223000025 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 471223000026 putative DNA binding surface [nucleotide binding]; other site 471223000027 dimer interface [polypeptide binding]; other site 471223000028 beta-clamp/clamp loader binding surface; other site 471223000029 beta-clamp/translesion DNA polymerase binding surface; other site 471223000030 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cl09940 471223000031 recombination protein F; Reviewed; Region: recF; PRK00064 471223000032 RecF is a recombinational DNA repair ATPase that maintains replication in the presence of DNA damage. When replication is prematurely disrupted by DNA damage, several recF pathway gene products play critical roles processing the arrested replication...; Region: ABC_RecF; cd03242 471223000033 Walker A/P-loop; other site 471223000034 ATP binding site [chemical binding]; other site 471223000035 Q-loop/lid; other site 471223000036 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 471223000037 ABC transporter signature motif; other site 471223000038 Walker B; other site 471223000039 D-loop; other site 471223000040 H-loop/switch region; other site 471223000041 DNA gyrase subunit B; Validated; Region: gyrB; PRK05644 471223000042 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 471223000043 Mg2+ binding site [ion binding]; other site 471223000044 G-X-G motif; other site 471223000045 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 471223000046 anchoring element; other site 471223000047 dimer interface [polypeptide binding]; other site 471223000048 ATP binding site [chemical binding]; other site 471223000049 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 471223000050 active site 471223000051 putative metal-binding site [ion binding]; other site 471223000052 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 471223000053 DNA gyrase subunit A; Validated; Region: PRK05560 471223000054 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes in DNA...; Region: TOP4c; cd00187 471223000055 CAP-like domain; other site 471223000056 active site 471223000057 primary dimer interface [polypeptide binding]; other site 471223000058 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 471223000059 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 471223000060 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 471223000061 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 471223000062 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 471223000063 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 471223000064 DNA-directed RNA polymerase, beta'' subunit; Region: rpoC2_cyan; TIGR02388 471223000065 c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206 471223000066 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 471223000067 Zn2+ binding site [ion binding]; other site 471223000068 Mg2+ binding site [ion binding]; other site 471223000069 YaaC-like Protein; Region: YaaC; pfam14175 471223000070 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 471223000071 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl09108 471223000072 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a key...; Region: CBS_pair_IMPDH; cd04601 471223000073 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of the guanine...; Region: IMPDH; cd00381 471223000074 active site 471223000075 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 471223000076 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 471223000077 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; cl06814 471223000078 pyridoxal 5'-phosphate synthase, synthase subunit Pdx1; Region: TIGR00343 471223000079 PdxS is a subunit of the pyridoxal 5'-phosphate (PLP) synthase, an important enzyme in deoxyxylulose 5-phosphate (DXP)-independent pathway for de novo biosynthesis of PLP, present in some eubacteria, in archaea, fungi, plants, plasmodia, and some...; Region: pdxS; cd04727 471223000080 active site 471223000081 multimer interface [polypeptide binding]; other site 471223000082 Glutamine amidotransferase [Amino acid transport and metabolism]; Region: HisH; COG0118 471223000083 Glutamine Amidotransferase (GATase_I) involved in pyridoxine biosynthesis; Region: GATase1_PB; cd01749 471223000084 predicted active site [active] 471223000085 catalytic triad [active] 471223000086 seryl-tRNA synthetase; Provisional; Region: PRK05431 471223000087 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 471223000088 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme bound...; Region: SerRS_core; cd00770 471223000089 dimer interface [polypeptide binding]; other site 471223000090 active site 471223000091 motif 1; other site 471223000092 motif 2; other site 471223000093 motif 3; other site 471223000094 Deoxynucleoside kinases [Nucleotide transport and metabolism]; Region: COG1428 471223000095 Deoxyribonucleoside kinase (dNK) catalyzes the phosphorylation of deoxyribonucleosides to yield corresponding monophosphates (dNMPs). This family consists of various deoxynucleoside kinases including deoxyribo- cytidine (EC 2.7.1.74), guanosine (EC 2.7.1; Region: dNK; cd01673 471223000096 Substrate-binding site [chemical binding]; other site 471223000097 Substrate specificity [chemical binding]; other site 471223000098 Deoxynucleoside kinases [Nucleotide transport and metabolism]; Region: COG1428 471223000099 Deoxyribonucleoside kinase (dNK) catalyzes the phosphorylation of deoxyribonucleosides to yield corresponding monophosphates (dNMPs). This family consists of various deoxynucleoside kinases including deoxyribo- cytidine (EC 2.7.1.74), guanosine (EC 2.7.1; Region: dNK; cd01673 471223000100 Substrate-binding site [chemical binding]; other site 471223000101 Substrate specificity [chemical binding]; other site 471223000102 Predicted glycosyl hydrolase [General function prediction only]; Region: COG3858 471223000103 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118 471223000104 putative peptidoglycan binding site; other site 471223000105 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118 471223000106 putative peptidoglycan binding site; other site 471223000107 Cortical fragment-lytic enzyme (CFLE) is a peptidoglycan hydrolase involved in bacterial endospore germination. CFLE is expressed as an inactive preprotein (called SleB) in the forespore compartment of sporulating cells. SleB translocates across the...; Region: GH18_CFLE_spore_hydrolase; cd02874 471223000108 active site 471223000109 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 471223000110 nucleoside/Zn binding site; other site 471223000111 dimer interface [polypeptide binding]; other site 471223000112 catalytic motif [active] 471223000113 DNA polymerase III subunits gamma and tau; Validated; Region: PRK05563 471223000114 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 471223000115 Walker A motif; other site 471223000116 ATP binding site [chemical binding]; other site 471223000117 Walker B motif; other site 471223000118 arginine finger; other site 471223000119 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 471223000120 YbaB/EbfC DNA-binding family; Region: YbaB_DNA_bd; cl00494 471223000121 recombination protein RecR; Reviewed; Region: recR; PRK00076 471223000122 RecR protein; Region: RecR; pfam02132 471223000123 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 471223000124 putative active site [active] 471223000125 putative metal-binding site [ion binding]; other site 471223000126 tetramer interface [polypeptide binding]; other site 471223000127 Protein of unknown function (DUF2508); Region: DUF2508; pfam10704 471223000128 SigmaK-factor processing regulatory protein BofA; Region: BofA; cl06466 471223000129 Inhibitor of sigma-G Gin; Region: Gin; pfam10764 471223000130 Arginine/lysine/ornithine decarboxylases [Amino acid transport and metabolism]; Region: LdcC; COG1982 471223000131 Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615 471223000132 homodimer interface [polypeptide binding]; other site 471223000133 pyridoxal 5'-phosphate binding site [chemical binding]; other site 471223000134 catalytic residue [active] 471223000135 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 471223000136 thymidylate kinase; Validated; Region: tmk; PRK00698 471223000137 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 471223000138 TMP-binding site; other site 471223000139 ATP-binding site [chemical binding]; other site 471223000140 DNA polymerase III subunit delta'; Validated; Region: PRK08058 471223000141 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 471223000142 PSP1 C-terminal conserved region; Region: PSP1; cl00770 471223000143 TSC-22/dip/bun family; Region: TSC22; cl01853 471223000144 Predicted O-methyltransferase [General function prediction only]; Region: COG4123 471223000145 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 471223000146 S-adenosylmethionine binding site [chemical binding]; other site 471223000147 Predicted methyltransferases [General function prediction only]; Region: COG0313 471223000148 Precorrin-3B methylase [Coenzyme metabolism]; Region: CobJ; cl00304 471223000149 Regulators of stationary/sporulation gene expression [Transcription]; Region: AbrB; COG2002 471223000150 Antidote-toxin recognition MazE; Region: Antitoxin-MazE; cl00877 471223000151 methionyl-tRNA synthetase; Reviewed; Region: PRK12267 471223000152 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 471223000153 active site 471223000154 HIGH motif; other site 471223000155 KMSKS motif; other site 471223000156 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 471223000157 tRNA binding surface [nucleotide binding]; other site 471223000158 anticodon binding site; other site 471223000159 tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins. This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties. MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800 471223000160 dimer interface [polypeptide binding]; other site 471223000161 putative tRNA-binding site [nucleotide binding]; other site 471223000162 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 471223000163 active site 471223000164 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3583 471223000165 Domain of unknown function (DUF348); Region: DUF348; pfam03990 471223000166 Domain of unknown function (DUF348); Region: DUF348; pfam03990 471223000167 Domain of unknown function (DUF348); Region: DUF348; pfam03990 471223000168 G5 domain; Region: G5; pfam07501 471223000169 3D domain; Region: 3D; cl01439 471223000170 ribonuclease M5; Region: 5S_RNA_mat_M5; TIGR00334 471223000171 TOPRIM_ RNase M5_like: The topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain found in Ribonuclease M5: (RNase M5) and other small primase-like proteins from bacteria and archaea. RNase M5 catalyzes the maturation of 5S rRNA in low...; Region: TOPRIM_RNase_M5_like; cd01027 471223000172 putative active site [active] 471223000173 putative metal binding site [ion binding]; other site 471223000174 Domain of unknown function (DUF4093); Region: DUF4093; pfam13331 471223000175 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 471223000176 YabG peptidase U57; Region: Peptidase_U57; cl05250 471223000177 Protein of unknown function (DUF1021); Region: DUF1021; cl01852 471223000178 Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269 471223000179 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: ipk; PRK00128 471223000180 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 471223000181 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 471223000182 pur operon repressor; Provisional; Region: PRK09213 471223000183 Bacterial purine repressor, N-terminal; Region: PuR_N; pfam09182 471223000184 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 471223000185 active site 471223000186 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 471223000187 homotrimer interaction site [polypeptide binding]; other site 471223000188 putative active site [active] 471223000189 SpoVG; Region: SpoVG; cl00915 471223000190 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14354 471223000191 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 471223000192 Substrate binding site; other site 471223000193 Mg++ binding site; other site 471223000194 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 471223000195 active site 471223000196 substrate binding site [chemical binding]; other site 471223000197 CoA binding site [chemical binding]; other site 471223000198 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259 471223000199 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 471223000200 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 471223000201 active site 471223000202 50S ribosomal protein L25/general stress protein Ctc; Reviewed; Region: PRK05618 471223000203 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 471223000204 5S rRNA interface [nucleotide binding]; other site 471223000205 CTC domain interface [polypeptide binding]; other site 471223000206 L16 interface [polypeptide binding]; other site 471223000207 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 471223000208 putative active site [active] 471223000209 catalytic residue [active] 471223000210 Protein of unknown function (DUF2757); Region: DUF2757; pfam10955 471223000211 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 471223000212 CarD-like/TRCF domain; Region: CarD_CdnL_TRCF; cl00588 471223000213 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 471223000214 ATP binding site [chemical binding]; other site 471223000215 putative Mg++ binding site [ion binding]; other site 471223000216 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 471223000217 nucleotide binding region [chemical binding]; other site 471223000218 ATP-binding site [chemical binding]; other site 471223000219 TRCF domain; Region: TRCF; cl04088 471223000220 stage V sporulation protein T; Region: spore_V_T; TIGR02851 471223000221 Antidote-toxin recognition MazE; Region: Antitoxin-MazE; cl00877 471223000222 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 471223000223 MatE; Region: MatE; cl10513 471223000224 Precorrin-3B methylase [Coenzyme metabolism]; Region: CobJ; cl00304 471223000225 Protein containing tetrapyrrole methyltransferase domain and MazG-like (predicted pyrophosphatase) domain [General function prediction only]; Region: COG3956 471223000226 MazG nucleotide pyrophosphohydrolase domain; Region: MazG; cl00345 471223000227 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 471223000228 RNA binding surface [nucleotide binding]; other site 471223000229 YabP family; Region: YabP; cl06766 471223000230 Spore cortex protein YabQ (Spore_YabQ); Region: Spore_YabQ; cl09801 471223000231 Septum formation initiator; Region: DivIC; cl11433 471223000232 hypothetical protein; Provisional; Region: PRK08582 471223000233 S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists of...; Region: S1_RPS1_repeat_hs4; cd05692 471223000234 RNA binding site [nucleotide binding]; other site 471223000235 stage II sporulation protein E; Region: spore_II_E; TIGR02865 471223000236 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cl00120 471223000237 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 471223000238 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 471223000239 metal ion-dependent adhesion site (MIDAS); other site 471223000240 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 471223000241 active site 471223000242 ATP binding site [chemical binding]; other site 471223000243 substrate binding site [chemical binding]; other site 471223000244 activation loop (A-loop); other site 471223000245 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 471223000246 Ligand Binding Site [chemical binding]; other site 471223000247 TilS substrate binding domain; Region: TilS; pfam09179 471223000248 B3/4 domain; Region: B3_4; cl11458 471223000249 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 471223000250 active site 471223000251 FtsH Extracellular; Region: FtsH_ext; pfam06480 471223000252 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 471223000253 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 471223000254 Walker A motif; other site 471223000255 ATP binding site [chemical binding]; other site 471223000256 Walker B motif; other site 471223000257 arginine finger; other site 471223000258 Peptidase family M41; Region: Peptidase_M41; pfam01434 471223000259 Type III pantothenate kinase; Region: Pan_kinase; cl09130 471223000260 Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114 471223000261 Heat shock protein 33 (Hsp33): Cytosolic protein that acts as a molecular chaperone under oxidative conditions. In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498 471223000262 dimerization interface [polypeptide binding]; other site 471223000263 domain crossover interface; other site 471223000264 redox-dependent activation switch; other site 471223000265 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 471223000266 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 471223000267 dimer interface [polypeptide binding]; other site 471223000268 pyridoxal 5'-phosphate binding site [chemical binding]; other site 471223000269 catalytic residue [active] 471223000270 DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808 471223000271 para-aminobenzoate synthase component II; Provisional; Region: PRK08857 471223000272 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 471223000273 glutamine binding [chemical binding]; other site 471223000274 catalytic triad [active] 471223000275 PyridoxaL 5'-Phosphate Dependent Enzymes class IV (PLPDE_IV). This D-amino acid superfamily, one of five classes of PLPDE, consists of branched-chain amino acid aminotransferases (BCAT), D-amino acid transferases (DAAT), and 4-amino-4-deoxychorismate...; Region: PLPDE_IV; cl00224 471223000276 homodimer interface [polypeptide binding]; other site 471223000277 substrate-cofactor binding pocket; other site 471223000278 pyridoxal 5'-phosphate binding site [chemical binding]; other site 471223000279 catalytic residue [active] 471223000280 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 471223000281 dihydropteroate synthase; Region: DHPS; TIGR01496 471223000282 substrate binding pocket [chemical binding]; other site 471223000283 dimer interface [polypeptide binding]; other site 471223000284 inhibitor binding site; inhibition site 471223000285 Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534 471223000286 homooctamer interface [polypeptide binding]; other site 471223000287 active site 471223000288 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 471223000289 catalytic center binding site [active] 471223000290 ATP binding site [chemical binding]; other site 471223000291 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 471223000292 non-specific DNA binding site [nucleotide binding]; other site 471223000293 salt bridge; other site 471223000294 sequence-specific DNA binding site [nucleotide binding]; other site 471223000295 DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808 471223000296 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 471223000297 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 471223000298 dimer interface [polypeptide binding]; other site 471223000299 putative anticodon binding site; other site 471223000300 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 471223000301 motif 1; other site 471223000302 active site 471223000303 motif 2; other site 471223000304 motif 3; other site 471223000305 DDE superfamily endonuclease; Region: DDE_5; cl02413 471223000306 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 471223000307 Archaeal putative transposase ISC1217; Region: DDE_Tnp_2; pfam04693 471223000308 Firmicute transcriptional repressor of class III stress genes (CtsR); Region: CtsR; cl01850 471223000309 Modulator of heat shock repressor CtsR, McsA [Signal transduction mechanisms]; Region: COG3880 471223000310 UvrB/uvrC motif; Region: UVR; pfam02151 471223000311 ATP:guanido phosphotransferase; Provisional; Region: PRK01059 471223000312 Phosphagen (guanidino) kinases found in bacteria; Region: bacterial_phosphagen_kinase; cd07930 471223000313 ADP binding site [chemical binding]; other site 471223000314 phosphagen binding site; other site 471223000315 substrate specificity loop; other site 471223000316 Clp protease ATP binding subunit; Region: clpC; CHL00095 471223000317 Clp amino terminal domain; Region: Clp_N; pfam02861 471223000318 Clp amino terminal domain; Region: Clp_N; pfam02861 471223000319 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 471223000320 Walker A motif; other site 471223000321 ATP binding site [chemical binding]; other site 471223000322 Walker B motif; other site 471223000323 arginine finger; other site 471223000324 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 471223000325 Walker A motif; other site 471223000326 ATP binding site [chemical binding]; other site 471223000327 Walker B motif; other site 471223000328 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; cl11083 471223000329 DNA repair protein RadA; Provisional; Region: PRK11823 471223000330 Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121 471223000331 Walker A motif/ATP binding site; other site 471223000332 ATP binding site [chemical binding]; other site 471223000333 Walker B motif; other site 471223000334 Subunit ChlI of Mg-chelatase; Region: ChlI; cl12214 471223000335 Integral membrane protein (PIN domain superfamily) [General function prediction only]; Region: COG4956 471223000336 PIN domain of Thermus Thermophilus Hb8, uncharacterized Bacillus subtilis YacL, and other bacterial homologs; Region: PIN_YacL; cd09877 471223000337 putative active site [active] 471223000338 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 471223000339 substrate binding site; other site 471223000340 dimer interface; other site 471223000341 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554 471223000342 homotrimer interaction site [polypeptide binding]; other site 471223000343 zinc binding site [ion binding]; other site 471223000344 CDP-binding sites; other site 471223000345 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 471223000346 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 471223000347 HIGH motif; other site 471223000348 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 471223000349 active site 471223000350 KMSKS motif; other site 471223000351 serine O-acetyltransferase; Region: cysE; TIGR01172 471223000352 Serine acetyltransferase, N-terminal; Region: SATase_N; cl05762 471223000353 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 471223000354 trimer interface [polypeptide binding]; other site 471223000355 active site 471223000356 substrate binding site [chemical binding]; other site 471223000357 CoA binding site [chemical binding]; other site 471223000358 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 471223000359 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 471223000360 active site 471223000361 HIGH motif; other site 471223000362 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 471223000363 KMSKS motif; other site 471223000364 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 471223000365 tRNA binding surface [nucleotide binding]; other site 471223000366 anticodon binding site; other site 471223000367 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 471223000368 active site 471223000369 metal binding site [ion binding]; metal-binding site 471223000370 dimerization interface [polypeptide binding]; other site 471223000371 rRNA methylase, putative, group 3; Region: rRNA_methyl_3; TIGR00186 471223000372 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; cl06870 471223000373 SpoU rRNA Methylase family; Region: SpoU_methylase; cl00362 471223000374 YacP-like NYN domain; Region: NYN_YacP; cl01491 471223000375 RNA polymerase factor sigma-70; Validated; Region: PRK08295 471223000376 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 471223000377 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 471223000378 Ribosomal protein L33; Region: Ribosomal_L33; cl00383 471223000379 SecE/Sec61-gamma subunits of protein translocation complex; Region: SecE; cl00481 471223000380 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 471223000381 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 471223000382 putative homodimer interface [polypeptide binding]; other site 471223000383 KOW motif; Region: KOW; cl00354 471223000384 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 471223000385 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 471223000386 23S rRNA interface [nucleotide binding]; other site 471223000387 L7/L12 interface [polypeptide binding]; other site 471223000388 putative thiostrepton binding site; other site 471223000389 L25 interface [polypeptide binding]; other site 471223000390 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 471223000391 mRNA/rRNA interface [nucleotide binding]; other site 471223000392 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 471223000393 23S rRNA interface [nucleotide binding]; other site 471223000394 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 471223000395 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 471223000396 core dimer interface [polypeptide binding]; other site 471223000397 peripheral dimer interface [polypeptide binding]; other site 471223000398 L10 interface [polypeptide binding]; other site 471223000399 L11 interface [polypeptide binding]; other site 471223000400 putative EF-Tu interaction site [polypeptide binding]; other site 471223000401 putative EF-G interaction site [polypeptide binding]; other site 471223000402 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 471223000403 S-adenosylmethionine binding site [chemical binding]; other site 471223000404 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 471223000405 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl04593 471223000406 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 471223000407 RPB1 interaction site [polypeptide binding]; other site 471223000408 RPB10 interaction site [polypeptide binding]; other site 471223000409 RPB11 interaction site [polypeptide binding]; other site 471223000410 RPB3 interaction site [polypeptide binding]; other site 471223000411 RPB12 interaction site [polypeptide binding]; other site 471223000412 DNA-directed RNA polymerase subunit beta'; Provisional; Region: PRK00566 471223000413 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 471223000414 RNA polymerase Rpb1, domain 2; Region: RNA_pol_Rpb1_2; cl11591 471223000415 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 471223000416 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 471223000417 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 471223000418 Rpb1 (beta') - Rpb6 (omega) interaction site [polypeptide binding]; other site 471223000419 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 471223000420 G-loop; other site 471223000421 DNA binding site [nucleotide binding] 471223000422 Ribosomal protein L7Ae/L30e/S12e/Gadd45 family; Region: Ribosomal_L7Ae; cl00600 471223000423 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 471223000424 S17 interaction site [polypeptide binding]; other site 471223000425 S8 interaction site; other site 471223000426 16S rRNA interaction site [nucleotide binding]; other site 471223000427 streptomycin interaction site [chemical binding]; other site 471223000428 23S rRNA interaction site [nucleotide binding]; other site 471223000429 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 471223000430 Ribosomal protein S7p/S5e; Region: Ribosomal_S7; cl00313 471223000431 elongation factor G; Reviewed; Region: PRK00007 471223000432 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 471223000433 G1 box; other site 471223000434 putative GEF interaction site [polypeptide binding]; other site 471223000435 GTP/Mg2+ binding site [chemical binding]; other site 471223000436 Switch I region; other site 471223000437 G2 box; other site 471223000438 G3 box; other site 471223000439 Switch II region; other site 471223000440 G4 box; other site 471223000441 G5 box; other site 471223000442 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 471223000443 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 471223000444 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 471223000445 elongation factor Tu; Reviewed; Region: PRK00049 471223000446 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 471223000447 G1 box; other site 471223000448 GEF interaction site [polypeptide binding]; other site 471223000449 GTP/Mg2+ binding site [chemical binding]; other site 471223000450 Switch I region; other site 471223000451 G2 box; other site 471223000452 G3 box; other site 471223000453 Switch II region; other site 471223000454 G4 box; other site 471223000455 G5 box; other site 471223000456 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 471223000457 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 471223000458 Antibiotic Binding Site [chemical binding]; other site 471223000459 Ribosomal protein S10p/S20e; Region: Ribosomal_S10; cl00314 471223000460 Ribosomal protein L3; Region: Ribosomal_L3; cl00324 471223000461 Ribosomal protein L4/L1 family; Region: Ribosomal_L4; cl00325 471223000462 Ribosomal protein L23; Region: Ribosomal_L23; cl00326 471223000463 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 471223000464 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 471223000465 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 471223000466 Ribosomal protein S19; Region: Ribosomal_S19; cl00350 471223000467 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 471223000468 putative translocon binding site; other site 471223000469 protein-rRNA interface [nucleotide binding]; other site 471223000470 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 471223000471 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 471223000472 G-X-X-G motif; other site 471223000473 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 471223000474 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 471223000475 23S rRNA interface [nucleotide binding]; other site 471223000476 5S rRNA interface [nucleotide binding]; other site 471223000477 putative antibiotic binding site [chemical binding]; other site 471223000478 L25 interface [polypeptide binding]; other site 471223000479 L27 interface [polypeptide binding]; other site 471223000480 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 471223000481 23S rRNA interface [nucleotide binding]; other site 471223000482 putative translocon interaction site; other site 471223000483 signal recognition particle (SRP54) interaction site; other site 471223000484 L23 interface [polypeptide binding]; other site 471223000485 trigger factor interaction site; other site 471223000486 Ribosomal protein S17; Region: Ribosomal_S17; cl00351 471223000487 Ribosomal protein L14p/L23e; Region: Ribosomal_L14; cl00328 471223000488 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 471223000489 KOW motif; Region: KOW; cl00354 471223000490 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 471223000491 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 471223000492 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 471223000493 Ribosomal protein S14p/S29e; Region: Ribosomal_S14; cl00355 471223000494 Ribosomal protein S8; Region: Ribosomal_S8; cl00330 471223000495 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 471223000496 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 471223000497 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 471223000498 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 471223000499 23S rRNA interface [nucleotide binding]; other site 471223000500 5S rRNA interface [nucleotide binding]; other site 471223000501 L27 interface [polypeptide binding]; other site 471223000502 L5 interface [polypeptide binding]; other site 471223000503 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 471223000504 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 471223000505 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 471223000506 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 471223000507 23S rRNA binding site [nucleotide binding]; other site 471223000508 Ribosomal protein L18e/L15; Region: Ribosomal_L18e; cl12022 471223000509 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK12907 471223000510 SecY translocase; Region: SecY; pfam00344 471223000511 adenylate kinase; Reviewed; Region: adk; PRK00279 471223000512 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 471223000513 AMP-binding site [chemical binding]; other site 471223000514 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 471223000515 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 471223000516 active site 471223000517 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 471223000518 rRNA binding site [nucleotide binding]; other site 471223000519 predicted 30S ribosome binding site; other site 471223000520 Ribosomal protein L36; Region: Ribosomal_L36; cl00380 471223000521 Ribosomal protein S13/S18; Region: Ribosomal_S13; cl00331 471223000522 Ribosomal protein S13 [Translation, ribosomal structure and biogenesis]; Region: RpsM; COG0099 471223000523 Ribosomal protein S11; Region: Ribosomal_S11; cl00332 471223000524 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 471223000525 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 471223000526 alphaNTD homodimer interface [polypeptide binding]; other site 471223000527 alphaNTD - beta interaction site [polypeptide binding]; other site 471223000528 alphaNTD - beta' interaction site [polypeptide binding]; other site 471223000529 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; cl11613 471223000530 Ribosomal protein L17; Region: Ribosomal_L17; cl00356 471223000531 cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13635 471223000532 Domain I of the ABC component of a cobalt transport family found in bacteria, archaea, and eukaryota. The transition metal cobalt is an essential component of many enzymes and must be transported into cells in appropriate amounts when needed. This ABC...; Region: ABC_cobalt_CbiO_domain1; cd03225 471223000533 Walker A/P-loop; other site 471223000534 ATP binding site [chemical binding]; other site 471223000535 Q-loop/lid; other site 471223000536 ABC transporter signature motif; other site 471223000537 Walker B; other site 471223000538 D-loop; other site 471223000539 H-loop/switch region; other site 471223000540 cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13634 471223000541 Domain I of the ABC component of a cobalt transport family found in bacteria, archaea, and eukaryota. The transition metal cobalt is an essential component of many enzymes and must be transported into cells in appropriate amounts when needed. This ABC...; Region: ABC_cobalt_CbiO_domain1; cd03225 471223000542 Walker A/P-loop; other site 471223000543 ATP binding site [chemical binding]; other site 471223000544 Q-loop/lid; other site 471223000545 ABC transporter signature motif; other site 471223000546 Walker B; other site 471223000547 D-loop; other site 471223000548 H-loop/switch region; other site 471223000549 Cobalt transport protein; Region: CbiQ; cl00463 471223000550 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 471223000551 PseudoU_synth_EcTruA: Pseudouridine synthase, Escherichia coli TruA like. This group consists of eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA, Pseudomonas aeruginosa truA and human pseudouridine synthase-like 1 (PUSL1); Region: PseudoU_synth_EcTruA; cd02570 471223000552 dimerization interface 3.5A [polypeptide binding]; other site 471223000553 active site 471223000554 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 471223000555 23S rRNA interface [nucleotide binding]; other site 471223000556 L3 interface [polypeptide binding]; other site 471223000557 Ribosomal protein S9/S16; Region: Ribosomal_S9; cl00334 471223000558 Protein of unknown function (DUF2521); Region: DUF2521; pfam10730 471223000559 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 471223000560 active site 471223000561 Domain of unknown function DUF59; Region: DUF59; cl00941 471223000562 antiporter inner membrane protein; Provisional; Region: PRK11670 471223000563 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 471223000564 Walker A motif; other site 471223000565 KinB-signalling pathway activation in sporulation; Region: KbaA; pfam14089 471223000566 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 471223000567 Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692 471223000568 Arginase family; Region: Arginase; cl00306 471223000569 RNA polymerase sigma factor SigW; Provisional; Region: PRK09641 471223000570 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 471223000571 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 471223000572 DNA binding residues [nucleotide binding] 471223000573 Predicted transmembrane transcriptional regulator (anti-sigma factor) [Transcription]; Region: COG5662 471223000574 Putative zinc-finger; Region: zf-HC2; cl15806 471223000575 Uncharacterized conserved protein [Function unknown]; Region: COG1624 471223000576 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 471223000577 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4856 471223000578 YbbR-like protein; Region: YbbR; pfam07949 471223000579 YbbR-like protein; Region: YbbR; pfam07949 471223000580 YbbR-like protein; Region: YbbR; pfam07949 471223000581 phosphoglucosamine mutase; Provisional; Region: glmM; PRK14316 471223000582 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 471223000583 active site 471223000584 substrate binding site [chemical binding]; other site 471223000585 metal binding site [ion binding]; metal-binding site 471223000586 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 471223000587 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 471223000588 glutaminase active site [active] 471223000589 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 471223000590 dimer interface [polypeptide binding]; other site 471223000591 active site 471223000592 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 471223000593 dimer interface [polypeptide binding]; other site 471223000594 active site 471223000595 Flavin Reductases; Region: FlaRed; cl00801 471223000596 Transposase, Mutator family; Region: Transposase_mut; pfam00872 471223000597 MULE transposase domain; Region: MULE; pfam10551 471223000598 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 471223000599 transposase, putative, N-terminal domain; Region: tspaseT_teng_N; TIGR01765 471223000600 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 471223000601 Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282 471223000602 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 471223000603 Transposase; Region: DDE_Tnp_ISL3; pfam01610 471223000604 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 471223000605 dimerization interface [polypeptide binding]; other site 471223000606 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 471223000607 dimer interface [polypeptide binding]; other site 471223000608 phosphorylation site [posttranslational modification] 471223000609 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 471223000610 ATP binding site [chemical binding]; other site 471223000611 Mg2+ binding site [ion binding]; other site 471223000612 G-X-G motif; other site 471223000613 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 471223000614 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 471223000615 active site 471223000616 phosphorylation site [posttranslational modification] 471223000617 intermolecular recognition site; other site 471223000618 dimerization interface [polypeptide binding]; other site 471223000619 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 471223000620 DNA binding site [nucleotide binding] 471223000621 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 471223000622 transposase, putative, N-terminal domain; Region: tspaseT_teng_N; TIGR01765 471223000623 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 471223000624 Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282 471223000625 EamA-like transporter family; Region: EamA; cl01037 471223000626 Domain of unknown function (DUF4306); Region: DUF4306; pfam14154 471223000627 Helix-turn-helix domains; Region: HTH; cl00088 471223000628 hypothetical protein; Validated; Region: PRK07668 471223000629 Predicted dithiol-disulfide isomerase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FrnE; COG2761 471223000630 DsbA family, FrnE subfamily; FrnE is a DsbA-like protein containing a CXXC motif. It is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the aromatic antibiotics frenolicin and nanaomycins; Region: DsbA_FrnE; cd03024 471223000631 catalytic residues [active] 471223000632 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; cl00986 471223000633 DinB superfamily; Region: DinB_2; pfam12867 471223000634 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 471223000635 active site 471223000636 metal binding site [ion binding]; metal-binding site 471223000637 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368 471223000638 Sulfatase; Region: Sulfatase; cl10460 471223000639 putative sporulation protein YtaF; Region: spore_YtaF; TIGR02840 471223000640 Domain of unknown function DUF; Region: DUF204; pfam02659 471223000641 Domain of unknown function DUF; Region: DUF204; pfam02659 471223000642 Sporulation control protein [General function prediction only]; Region: Spo0M; COG4326 471223000643 SpoOM protein; Region: Spo0M; pfam07070 471223000644 Bacitracin resistance protein BacA; Region: BacA; cl00858 471223000645 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 471223000646 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 471223000647 active site 471223000648 phosphorylation site [posttranslational modification] 471223000649 intermolecular recognition site; other site 471223000650 dimerization interface [polypeptide binding]; other site 471223000651 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 471223000652 DNA binding residues [nucleotide binding] 471223000653 dimerization interface [polypeptide binding]; other site 471223000654 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 471223000655 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 471223000656 ATP binding site [chemical binding]; other site 471223000657 Mg2+ binding site [ion binding]; other site 471223000658 G-X-G motif; other site 471223000659 Transposase IS200 like; Region: Y1_Tnp; cl00848 471223000660 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 471223000661 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 471223000662 Probable transposase; Region: OrfB_IS605; pfam01385 471223000663 Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282 471223000664 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; cl14891 471223000665 Integrase core domain; Region: rve; cl01316 471223000666 Helix-turn-helix domains; Region: HTH; cl00088 471223000667 Winged helix-turn helix; Region: HTH_29; pfam13551 471223000668 Helix-turn-helix domains; Region: HTH; cl00088 471223000669 Winged helix-turn helix; Region: HTH_33; pfam13592 471223000670 Integrase core domain; Region: rve; cl01316 471223000671 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 471223000672 undecaprenyldiphospho-muramoylpentapeptide beta-N-acetylglucosaminyltransferase; Reviewed; Region: PRK12446 471223000673 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 471223000674 active site 471223000675 homodimer interface [polypeptide binding]; other site 471223000676 Catalytic NodB homology domain of uncharacterized bacterial polysaccharide deacetylases; Region: CE4_NodB_like_3; cd10959 471223000677 NodB motif; other site 471223000678 putative active site [active] 471223000679 putative catalytic site [active] 471223000680 putative Zn binding site [ion binding]; other site 471223000681 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 471223000682 Monogalactosyldiacylglycerol (MGDG) synthase; Region: MGDG_synth; pfam06925 471223000683 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 471223000684 D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966 471223000685 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 471223000686 ATP-grasp domain; Region: ATP-grasp_4; cl03087 471223000687 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 471223000688 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase; Region: murF; TIGR01143 471223000689 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 471223000690 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 471223000691 Esterase/lipase [General function prediction only]; Region: COG1647 471223000692 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 471223000693 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 471223000694 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 471223000695 ATP binding site [chemical binding]; other site 471223000696 Mg++ binding site [ion binding]; other site 471223000697 motif III; other site 471223000698 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 471223000699 nucleotide binding region [chemical binding]; other site 471223000700 ATP-binding site [chemical binding]; other site 471223000701 Rhomboid family; Region: Rhomboid; cl11446 471223000702 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; cl00500 471223000703 Outer membrane lipoprotein carrier protein LolA; Region: LolA; cl01065 471223000704 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 471223000705 alanine racemase; Reviewed; Region: alr; PRK00053 471223000706 active site 471223000707 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 471223000708 dimer interface [polypeptide binding]; other site 471223000709 substrate binding site [chemical binding]; other site 471223000710 catalytic residues [active] 471223000711 Predicted transcriptional regulators containing the CopG/Arc/MetJ DNA-binding domain and a metal-binding domain [Transcription]; Region: NikR; COG0864 471223000712 PemK-like protein; Region: PemK; cl00995 471223000713 Transcriptional accessory protein [Transcription]; Region: Tex; COG2183 471223000714 Tex-like protein N-terminal domain; Region: Tex_N; pfam09371 471223000715 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD includes...; Region: RuvC_resolvase; cl00243 471223000716 Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872 471223000717 S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685 471223000718 RNA binding site [nucleotide binding]; other site 471223000719 SprT homologues; Region: SprT; cl01182 471223000720 hypothetical protein; Provisional; Region: PRK04351 471223000721 Uncharacterized P-loop hydrolase UPF0079; Region: UPF0079; cl00520 471223000722 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl14000 471223000723 Glycoprotease family; Region: Peptidase_M22; pfam00814 471223000724 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 471223000725 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 471223000726 Coenzyme A binding pocket [chemical binding]; other site 471223000727 UGMP family protein; Validated; Region: PRK09604 471223000728 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl14000 471223000729 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; cl14891 471223000730 Integrase core domain; Region: rve; cl01316 471223000731 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 471223000732 Probable transposase; Region: OrfB_IS605; pfam01385 471223000733 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 471223000734 Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282 471223000735 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 471223000736 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 471223000737 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 471223000738 ABC transporter; Region: ABC_tran_2; pfam12848 471223000739 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 471223000740 ABC transporter; Region: ABC_tran_2; pfam12848 471223000741 MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420 471223000742 trimer interface [polypeptide binding]; other site 471223000743 dimer interface [polypeptide binding]; other site 471223000744 putative active site [active] 471223000745 redox-sensing transcriptional repressor Rex; Provisional; Region: PRK05472 471223000746 Putative DNA-binding protein N-terminus; Region: Put_DNA-bind_N; pfam06971 471223000747 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 471223000748 DDE superfamily endonuclease; Region: DDE_5; cl02413 471223000749 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 471223000750 Archaeal putative transposase ISC1217; Region: DDE_Tnp_2; pfam04693 471223000751 mttA/Hcf106 family; Region: MttA_Hcf106; cl00788 471223000752 Sec-independent protein translocase protein (TatC); Region: TatC; cl00521 471223000753 Domain of unknown function (DUF4305); Region: DUF4305; pfam14146 471223000754 CAAX protease self-immunity; Region: Abi; cl00558 471223000755 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 471223000756 oligomerisation interface [polypeptide binding]; other site 471223000757 mobile loop; other site 471223000758 roof hairpin; other site 471223000759 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 471223000760 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 471223000761 ring oligomerisation interface [polypeptide binding]; other site 471223000762 ATP/Mg binding site [chemical binding]; other site 471223000763 stacking interactions; other site 471223000764 hinge regions; other site 471223000765 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 471223000766 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 471223000767 Putative regulatory, ligand-binding protein related to C-terminal domains of K+ channels [Inorganic ion transport and metabolism]; Region: COG0490 471223000768 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl15357 471223000769 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 471223000770 transposase, putative, N-terminal domain; Region: tspaseT_teng_N; TIGR01765 471223000771 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 471223000772 Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282 471223000773 Transglutaminase-like superfamily; Region: Transglut_core; cl10469 471223000774 Domain of unknown function (DUF4129); Region: DUF4129; pfam13559 471223000775 GMP synthase; Reviewed; Region: guaA; PRK00074 471223000776 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 471223000777 AMP/PPi binding site [chemical binding]; other site 471223000778 candidate oxyanion hole; other site 471223000779 catalytic triad [active] 471223000780 potential glutamine specificity residues [chemical binding]; other site 471223000781 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 471223000782 ATP Binding subdomain [chemical binding]; other site 471223000783 Ligand Binding sites [chemical binding]; other site 471223000784 Dimerization subdomain; other site 471223000785 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 471223000786 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 471223000787 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 471223000788 ABC-2 type transporter; Region: ABC2_membrane; cl11417 471223000789 ABC-2 type transporter; Region: ABC2_membrane; cl11417 471223000790 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 471223000791 gallidermin-class lantibiotic protection ABC transporter, ATP-binding subunit; Region: galliderm_ABC; TIGR03740 471223000792 The BcrA subfamily represents ABC transporters involved in peptide antibiotic resistance. Bacitracin is a dodecapeptide antibiotic produced by B. licheniformis and B. subtilis. The synthesis of bacitracin is non-ribosomally catalyzed by a multienzyme...; Region: ABC_BcrA_bacitracin_resist; cd03268 471223000793 Walker A/P-loop; other site 471223000794 ATP binding site [chemical binding]; other site 471223000795 Q-loop/lid; other site 471223000796 ABC transporter signature motif; other site 471223000797 Walker B; other site 471223000798 D-loop; other site 471223000799 H-loop/switch region; other site 471223000800 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 471223000801 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 471223000802 active site 471223000803 phosphorylation site [posttranslational modification] 471223000804 intermolecular recognition site; other site 471223000805 dimerization interface [polypeptide binding]; other site 471223000806 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 471223000807 DNA binding site [nucleotide binding] 471223000808 Transposase DDE domain group 1; Region: DDE_Tnp_1_4; pfam13701 471223000809 Domain of unknown function (DUF4277); Region: DUF4277; pfam14104 471223000810 Transposase [DNA replication, recombination, and repair]; Region: COG5421 471223000811 Uncharacterized protein family (UPF0236); Region: UPF0236; pfam06782 471223000812 Transposase domain (DUF772); Region: DUF772; cl15789 471223000813 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 471223000814 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 471223000815 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 471223000816 putative dimer interface [polypeptide binding]; other site 471223000817 DDE superfamily endonuclease; Region: DDE_5; cl02413 471223000818 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 471223000819 Archaeal putative transposase ISC1217; Region: DDE_Tnp_2; pfam04693 471223000820 AIR carboxylase; Region: AIRC; cl00310 471223000821 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 471223000822 ATP-grasp domain; Region: ATP-grasp_4; cl03087 471223000823 adenylosuccinate lyase; Provisional; Region: PRK07492 471223000824 Adenylsuccinate lyase (ASL)_subgroup 1; Region: Adenylsuccinate_lyase_1; cd01360 471223000825 tetramer interface [polypeptide binding]; other site 471223000826 active site 471223000827 phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362 471223000828 bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415 471223000829 ATP binding site [chemical binding]; other site 471223000830 active site 471223000831 substrate binding site [chemical binding]; other site 471223000832 Phosphoribosylformylglycinamidine (FGAM) synthase; Region: PurS; cl00789 471223000833 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 471223000834 Glutamine amidotransferase class-I; Region: GATase; pfam00117 471223000835 putative active site [active] 471223000836 catalytic triad [active] 471223000837 phosphoribosylformylglycinamidine synthase II; Provisional; Region: PRK01213 471223000838 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 471223000839 dimerization interface [polypeptide binding]; other site 471223000840 ATP binding site [chemical binding]; other site 471223000841 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 471223000842 dimerization interface [polypeptide binding]; other site 471223000843 ATP binding site [chemical binding]; other site 471223000844 amidophosphoribosyltransferase; Provisional; Region: PRK07631 471223000845 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 471223000846 active site 471223000847 tetramer interface [polypeptide binding]; other site 471223000848 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 471223000849 active site 471223000850 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 471223000851 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 471223000852 dimerization interface [polypeptide binding]; other site 471223000853 putative ATP binding site [chemical binding]; other site 471223000854 phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647 471223000855 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 471223000856 active site 471223000857 substrate binding site [chemical binding]; other site 471223000858 cosubstrate binding site; other site 471223000859 catalytic site [active] 471223000860 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 471223000861 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 471223000862 purine monophosphate binding site [chemical binding]; other site 471223000863 dimer interface [polypeptide binding]; other site 471223000864 putative catalytic residues [active] 471223000865 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 471223000866 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 471223000867 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 471223000868 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 471223000869 ATP-grasp domain; Region: ATP-grasp_4; cl03087 471223000870 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 471223000871 Protein of unknown function (DUF2892); Region: DUF2892; pfam11127 471223000872 Adenine deaminase [Nucleotide transport and metabolism]; Region: AdeC; COG1001 471223000873 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 471223000874 Adenine deaminase (AdeC) directly deaminates adenine to form hypoxanthine. This reaction is part of one of the adenine salvage pathways, as well as the degradation pathway. It is important for adenine utilization as a purine, as well as a nitrogen source...; Region: AdeC; cd01295 471223000875 active site 471223000876 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 471223000877 Protein of unknown function (DUF3048); Region: DUF3048; pfam11258 471223000878 Helix-turn-helix domains; Region: HTH; cl00088 471223000879 PcrB_like proteins. One member of this family, a protein from Archaeoglobus fulgidus, has been characterized as a (S)-3-O-geranylgeranylglyceryl phosphate synthase (AfGGGPS). AfGGGPS catalyzes the formation of an ether linkage between...; Region: PcrB_like; cd02812 471223000880 substrate binding site [chemical binding]; other site 471223000881 putative active site [active] 471223000882 dimer interface [polypeptide binding]; other site 471223000883 ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073 471223000884 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 471223000885 Family description; Region: UvrD_C_2; cl15862 471223000886 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 471223000887 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 471223000888 nucleotide binding pocket [chemical binding]; other site 471223000889 K-X-D-G motif; other site 471223000890 catalytic site [active] 471223000891 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 471223000892 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 471223000893 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786 471223000894 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 471223000895 Dimer interface [polypeptide binding]; other site 471223000896 CamS sex pheromone cAM373 precursor; Region: CamS; cl11554 471223000897 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 471223000898 Probable transposase; Region: OrfB_IS605; pfam01385 471223000899 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 471223000900 Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282 471223000901 1-pyrroline-5-carboxylate dehydrogenase; Provisional; Region: PRK03137 471223000902 Delta(1)-pyrroline-5-carboxylate dehydrogenase, RocA; Region: ALDH_PutA-P5CDH-RocA; cd07124 471223000903 Glutamate binding site [chemical binding]; other site 471223000904 homodimer interface [polypeptide binding]; other site 471223000905 NAD binding site [chemical binding]; other site 471223000906 catalytic residues [active] 471223000907 Helix-Turn-Helix DNA binding domain of the transcription regulators TipAL, Mta, and SkgA; Region: HTH_TipAL-Mta; cd01106 471223000908 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 471223000909 DNA binding residues [nucleotide binding] 471223000910 dimer interface [polypeptide binding]; other site 471223000911 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 471223000912 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 471223000913 MTABC3 (also known as ABCB6) is a mitochondrial ATP-binding cassette protein involved in iron homeostasis and one of four ABC transporters expressed in the mitochondrial inner membrane, the other three being MDL1(ABC7), MDL2, and ATM1. In fact, the...; Region: ABC_MTABC3_MDL1_MDL2; cd03249 471223000914 Walker A/P-loop; other site 471223000915 ATP binding site [chemical binding]; other site 471223000916 Q-loop/lid; other site 471223000917 ABC transporter signature motif; other site 471223000918 Walker B; other site 471223000919 D-loop; other site 471223000920 H-loop/switch region; other site 471223000921 Erythromycin esterase homolog [General function prediction only]; Region: COG2312 471223000922 Protein of unknown function, DUF399; Region: DUF399; cl01139 471223000923 Erythromycin esterase; Region: Erythro_esteras; pfam05139 471223000924 HutP; Region: HutP; cl07944 471223000925 Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332 471223000926 active sites [active] 471223000927 tetramer interface [polypeptide binding]; other site 471223000928 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 471223000929 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 471223000930 transposase, putative, N-terminal domain; Region: tspaseT_teng_N; TIGR01765 471223000931 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 471223000932 Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282 471223000933 Glu-tRNAGln amidotransferase C subunit; Region: Glu-tRNAGln; cl00495 471223000934 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 471223000935 Amidase; Region: Amidase; cl11426 471223000936 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 471223000937 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 471223000938 GatB domain; Region: GatB_Yqey; cl11497 471223000939 NMT1-like family; Region: NMT1_2; cl15260 471223000940 TRAP-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: Imp; COG2358 471223000941 C4-dicarboxylate anaerobic carrier; Region: DcuC; cl15356 471223000942 DctM-like transporters; Region: DctM; pfam06808 471223000943 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062 471223000944 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 471223000945 inhibitor-cofactor binding pocket; inhibition site 471223000946 pyridoxal 5'-phosphate binding site [chemical binding]; other site 471223000947 catalytic residue [active] 471223000948 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 471223000949 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 471223000950 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 471223000951 putative active site [active] 471223000952 Proteins of 100 residues with WXG; Region: WXG100; cl02005 471223000953 A pre-toxin domain with the TG motif; Region: PT-TG; pfam14449 471223000954 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 471223000955 ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism]; Region: OpuBA; COG1125 471223000956 OpuCA is a the ATP binding component of a bacterial solute transporter that serves a protective role to cells growing in a hyperosmolar environment. ABC (ATP-binding cassette) transporter nucleotide-binding domain; ABC transporters are a large family of...; Region: ABC_OpuCA_Osmoprotection; cd03295 471223000957 Walker A/P-loop; other site 471223000958 ATP binding site [chemical binding]; other site 471223000959 Q-loop/lid; other site 471223000960 ABC transporter signature motif; other site 471223000961 Walker B; other site 471223000962 D-loop; other site 471223000963 H-loop/switch region; other site 471223000964 FOG: CBS domain [General function prediction only]; Region: COG0517 471223000965 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with the ABC transporter OpuCA. OpuCA is the ATP binding component of a bacterial solute transporter that serves a protective role to cells growing...; Region: CBS_pair_ABC_OpuCA_assoc2; cd04583 471223000966 NMT1-like family; Region: NMT1_2; cl15260 471223000967 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 471223000968 conserved hypothetical protein YmdA/YtgF; Region: YmdA_YtgF; TIGR03319 471223000969 TIGR02677 family protein; Region: TIGR02677 471223000970 Protein of unknown function (DUF2397); Region: DUF2397; pfam09660 471223000971 Protein of unknown function (DUF2398); Region: DUF2398; cl09875 471223000972 TIGR02680 family protein; Region: TIGR02680 471223000973 Putative exonuclease SbcCD, C subunit; Region: SbcCD_C; pfam13558 471223000974 TIGR02679 family protein; Region: TIGR02679 471223000975 Protein of unknown function N-terminus (DUF3323); Region: DUF3323; pfam11796 471223000976 Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718 471223000977 L-Aminopeptidase D-amidase/D-esterase (DmpA) family; DmpA catalyzes the release of N-terminal D and L amino acids from peptide susbtrates. DmpA is synthesized as a single polypeptide precursor, which is autocatalytically cleaved to the active...; Region: DmpA; cd02253 471223000978 homodimer interface [polypeptide binding]; other site 471223000979 homotetramer interface [polypeptide binding]; other site 471223000980 active site pocket [active] 471223000981 cleavage site 471223000982 CRISPR/Cas system-associated protein Cas8b; Region: Cas8b_I-B; cl09718 471223000983 CRISPR/Cas system-associated RAMP superfamily protein Cas7; Region: Cas7_I-C; cl01465 471223000984 CRISPR-associated protein Cas5, subtype I-B/HMARI; Region: cas_Cas5h; TIGR02592 471223000985 CRISPR/Cas system-associated RAMP superfamily protein Cas5; Region: Cas5_I; cl12040 471223000986 CRISPR/Cas system-associated protein Cas3''; Region: Cas3''_I; cd09641 471223000987 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 471223000988 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641 471223000989 CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-B; cd09722 471223000990 CRISPR/Cas system-associated protein Cas2; Region: Cas2_I_II_III; cd09725 471223000991 CRISPR/Cas system-associated RAMP superfamily protein Cas6; Region: Cas6-I-III; cd09652 471223000992 CRISPR/Cas system-associated protein Csm6; Region: Csm6_III-A; cl01634 471223000993 CRISPR/Cas system-associated protein Csx1; Region: Csx1_III-U; cd09732 471223000994 CRISPR/Cas system-associated protein Csx1; Region: Csx1_III-U; cl14784 471223000995 CRISPR/Cas system-associated RAMP superfamily protein; Region: RAMP_I_III; cl00592 471223000996 CRISPR/Cas system-associated protein Cas10; Region: Cas10_III; cd09679 471223000997 CRISPR-associated protein Cas10/Cmr2, subtype III-B; Region: cas_TM1794_Cmr2; TIGR02577 471223000998 CRISPR-associated protein (Cas_Cmr3); Region: Cas_Cmr3; pfam09700 471223000999 CRISPR/Cas system-associated RAMP superfamily protein Cmr3; Region: Cmr3_III-B; cl12075 471223001000 CRISPR/Cas system-associated RAMP superfamily protein; Region: RAMP_I_III; cl00592 471223001001 CRISPR/Cas system-associated protein Cmr5; Region: Cmr5_III-B; cd09749 471223001002 CRISPR/Cas system-associated RAMP superfamily protein; Region: RAMP_I_III; cl00592 471223001003 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 471223001004 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 471223001005 Walker A/P-loop; other site 471223001006 ATP binding site [chemical binding]; other site 471223001007 Q-loop/lid; other site 471223001008 ABC transporter signature motif; other site 471223001009 Walker B; other site 471223001010 D-loop; other site 471223001011 H-loop/switch region; other site 471223001012 TOBE domain; Region: TOBE_2; cl01440 471223001013 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 471223001014 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 471223001015 dimer interface [polypeptide binding]; other site 471223001016 conserved gate region; other site 471223001017 putative PBP binding loops; other site 471223001018 ABC-ATPase subunit interface; other site 471223001019 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 471223001020 dimer interface [polypeptide binding]; other site 471223001021 conserved gate region; other site 471223001022 putative PBP binding loops; other site 471223001023 ABC-ATPase subunit interface; other site 471223001024 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 471223001025 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 471223001026 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 471223001027 Probable transposase; Region: OrfB_IS605; pfam01385 471223001028 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 471223001029 Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282 471223001030 DDE superfamily endonuclease; Region: DDE_5; cl02413 471223001031 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 471223001032 Archaeal putative transposase ISC1217; Region: DDE_Tnp_2; pfam04693 471223001033 Transposase, Mutator family; Region: Transposase_mut; pfam00872 471223001034 MULE transposase domain; Region: MULE; pfam10551 471223001035 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2268 471223001036 Band_7_flotillin: a subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. These two proteins are lipid raft-associated. Individual proteins of...; Region: Band_7_flotillin; cd03399 471223001037 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2268 471223001038 putative lipid kinase; Reviewed; Region: PRK13337 471223001039 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; cl01255 471223001040 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 471223001041 Probable transposase; Region: OrfB_IS605; pfam01385 471223001042 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 471223001043 Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282 471223001044 TRAM domain; Region: TRAM; cl01282 471223001045 23S rRNA (uracil-5-)-methyltransferase RumA; Region: rumA; TIGR00479 471223001046 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 471223001047 S-adenosylmethionine binding site [chemical binding]; other site 471223001048 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 471223001049 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 471223001050 catalytic residues [active] 471223001051 catalytic nucleophile [active] 471223001052 Recombinase; Region: Recombinase; pfam07508 471223001053 Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408 471223001054 Domain of unknown function (DUF4368); Region: DUF4368; pfam14287 471223001055 Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239 471223001056 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 471223001057 DNA binding residues [nucleotide binding] 471223001058 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 471223001059 PemK-like protein; Region: PemK; cl00995 471223001060 The band 7 domain of flotillin (reggie) like proteins. This group contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual proteins of this...; Region: Band_7; cl02525 471223001061 putative thiazole-containing bacteriocin maturation protein; Region: ocin_ThiF_like; TIGR03693 471223001062 MoeZ/MoeB domain; Region: MoeZ_MoeB; cl14816 471223001063 Transposase; Region: DEDD_Tnp_IS110; pfam01548 471223001064 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 471223001065 MoeZ/MoeB domain; Region: MoeZ_MoeB; cl14816 471223001066 YcaO-like family; Region: YcaO; pfam02624 471223001067 Uncharacterized conserved protein [Function unknown]; Region: COG1944; cl09146 471223001068 This family is the oxydase domain of NRPS (non-ribosomal peptide synthetase) and other proteins that modify polypeptides by cyclizing a thioester to form a ring. These include epoB, part of the epothilone biosynthesis pathway; tubD, part of the tubulysin...; Region: mcbC-like_oxidoreductase; cd02142 471223001069 NADPH bind site [chemical binding]; other site 471223001070 putative FMN binding site [chemical binding]; other site 471223001071 This family is the oxydase domain of NRPS (non-ribosomal peptide synthetase) and other proteins that modify polypeptides by cyclizing a thioester to form a ring. These include epoB, part of the epothilone biosynthesis pathway; tubD, part of the tubulysin...; Region: mcbC-like_oxidoreductase; cd02142 471223001072 NADPH bind site [chemical binding]; other site 471223001073 putative FMN binding site [chemical binding]; other site 471223001074 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 471223001075 (2R,3R)-2,3-butanediol dehydrogenase; Region: butanediol_DH_like; cd08233 471223001076 putative NAD(P) binding site [chemical binding]; other site 471223001077 catalytic Zn binding site [ion binding]; other site 471223001078 The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425 471223001079 active site 471223001080 8-oxo-dGMP binding site [chemical binding]; other site 471223001081 nudix motif; other site 471223001082 metal binding site [ion binding]; metal-binding site 471223001083 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 471223001084 PLD-like domain; Region: PLDc_2; pfam13091 471223001085 putative active site [active] 471223001086 catalytic site [active] 471223001087 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 471223001088 ATP binding site [chemical binding]; other site 471223001089 putative Mg++ binding site [ion binding]; other site 471223001090 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 471223001091 nucleotide binding region [chemical binding]; other site 471223001092 ATP-binding site [chemical binding]; other site 471223001093 Domain of unknown function (DUF3427); Region: DUF3427; pfam11907 471223001094 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 471223001095 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; cl11611 471223001096 NTP_transferases catalyze the transfer of nucleotides onto phosphosugars; Region: NTP_transferase; cd04181 471223001097 active site 471223001098 Substrate binding site; other site 471223001099 Mg++ binding site; other site 471223001100 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 471223001101 putative trimer interface [polypeptide binding]; other site 471223001102 putative CoA binding site [chemical binding]; other site 471223001103 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 471223001104 This family is most closely related to the GT1 family of glycosyltransferases. ORF704 in E. coli has been shown to be involved in the biosynthesis of O-specific mannose homopolysaccharides; Region: GT1_ecORF704_like; cd03822 471223001105 Highly conserved protein containing a thioredoxin domain [Posttranslational modification, protein turnover, chaperones]; Region: COG1331 471223001106 phosphoglucosamine mutase; Region: Arch_GlmM; TIGR03990 471223001107 The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a...; Region: PMM_PGM; cd03089 471223001108 active site 471223001109 substrate binding site [chemical binding]; other site 471223001110 metal binding site [ion binding]; metal-binding site 471223001111 Protein of unknown function (DUF3147); Region: DUF3147; pfam11345 471223001112 Transposase, Mutator family; Region: Transposase_mut; pfam00872 471223001113 MULE transposase domain; Region: MULE; pfam10551 471223001114 Sensory domain found in PocR; Region: PocR; pfam10114 471223001115 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 471223001116 DNA binding residues [nucleotide binding] 471223001117 dimerization interface [polypeptide binding]; other site 471223001118 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 471223001119 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 471223001120 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 471223001121 anti sigma factor interaction site; other site 471223001122 regulatory phosphorylation site [posttranslational modification]; other site 471223001123 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 471223001124 PAS fold; Region: PAS_3; pfam08447 471223001125 putative active site [active] 471223001126 heme pocket [chemical binding]; other site 471223001127 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 471223001128 PAS domain; Region: PAS_9; pfam13426 471223001129 putative active site [active] 471223001130 heme pocket [chemical binding]; other site 471223001131 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cl00120 471223001132 RDD family; Region: RDD; cl00746 471223001133 Domain of unknown function (DUF2935); Region: DUF2935; pfam11155 471223001134 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 471223001135 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 471223001136 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 471223001137 dimer interface [polypeptide binding]; other site 471223001138 putative CheW interface [polypeptide binding]; other site 471223001139 thiamine biosynthesis protein ThiC; Provisional; Region: PRK09284 471223001140 ThiC-associated domain; Region: ThiC-associated; pfam13667 471223001141 ThiC family; Region: ThiC; cl08031 471223001142 N-methylhydantoinase B/acetone carboxylase, alpha subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuB; COG0146 471223001143 N-methylhydantoinase A/acetone carboxylase, beta subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuA; COG0145 471223001144 Hydantoinase/oxoprolinase N-terminal region; Region: Hydant_A_N; pfam05378 471223001145 Hydantoinase/oxoprolinase; Region: Hydantoinase_A; cl00668 471223001146 Adenosylmethionine-8-amino-7-oxononanoate aminotransferase [Coenzyme metabolism]; Region: BioA; COG0161 471223001147 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 471223001148 inhibitor-cofactor binding pocket; inhibition site 471223001149 pyridoxal 5'-phosphate binding site [chemical binding]; other site 471223001150 catalytic residue [active] 471223001151 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 471223001152 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 471223001153 tetramerization interface [polypeptide binding]; other site 471223001154 NAD(P) binding site [chemical binding]; other site 471223001155 catalytic residues [active] 471223001156 LL-diaminopimelate aminotransferase; Provisional; Region: PRK09276 471223001157 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 471223001158 pyridoxal 5'-phosphate binding site [chemical binding]; other site 471223001159 homodimer interface [polypeptide binding]; other site 471223001160 catalytic residue [active] 471223001161 thiamine pyrophosphate protein; Validated; Region: PRK08199 471223001162 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 471223001163 PYR/PP interface [polypeptide binding]; other site 471223001164 dimer interface [polypeptide binding]; other site 471223001165 TPP binding site [chemical binding]; other site 471223001166 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; cl00815 471223001167 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cd00568 471223001168 TPP-binding site [chemical binding]; other site 471223001169 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 471223001170 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 471223001171 NAD(P) binding site [chemical binding]; other site 471223001172 catalytic residues [active] 471223001173 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 471223001174 Saccharopine dehydrogenase; Region: Saccharop_dh; pfam03435 471223001175 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4877 471223001176 A subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual...; Region: Band_7_2; cd03402 471223001177 Integral membrane protein TerC family; Region: TerC; cl10468 471223001178 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 471223001179 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 471223001180 Uncharacterized ACR, YkgG family COG1556; Region: DUF162; cl00674 471223001181 iron-sulfur cluster-binding protein; Region: TIGR00273 471223001182 Uncharacterized ACR, YkgG family COG1556; Region: DUF162; cl00674 471223001183 Domain of unknown function (DUF3390); Region: DUF3390; pfam11870 471223001184 Cysteine-rich domain; Region: CCG; pfam02754 471223001185 Cysteine-rich domain; Region: CCG; pfam02754 471223001186 Transcriptional regulators [Transcription]; Region: FadR; COG2186 471223001187 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 471223001188 DNA-binding site [nucleotide binding]; DNA binding site 471223001189 FCD domain; Region: FCD; cl11656 471223001190 glycolate transporter; Provisional; Region: PRK09695 471223001191 L-lactate permease; Region: Lactate_perm; cl00701 471223001192 rod shape-determining protein MreB; Provisional; Region: PRK13930 471223001193 Actin; An ubiquitous protein involved in the formation of filaments that are a major component of the cytoskeleton. Interaction with myosin provides the basis of muscular contraction and many aspects of cell motility. Each actin protomer binds one...; Region: ACTIN; cl11528 471223001194 ATP binding site [chemical binding]; other site 471223001195 gelsolin binding site; other site 471223001196 profilin binding site; other site 471223001197 NlpC/P60 family; Region: NLPC_P60; cl11438 471223001198 sensory histidine kinase DcuS; Provisional; Region: PRK11086 471223001199 PAS domain S-box; Region: sensory_box; TIGR00229 471223001200 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 471223001201 putative active site [active] 471223001202 heme pocket [chemical binding]; other site 471223001203 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 471223001204 metal binding site [ion binding]; metal-binding site 471223001205 active site 471223001206 I-site; other site 471223001207 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 471223001208 Domain of unknown function (DUF1992); Region: DUF1992; cl08096 471223001209 precorrin-2 dehydrogenase; Reviewed; Region: PRK06718 471223001210 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 471223001211 GlcNAc-PI de-N-acetylase; Region: PIG-L; cl00929 471223001212 Protein of unknown function (DUF1806); Region: DUF1806; pfam08830 471223001213 Arginase family; Region: Arginase; cl00306 471223001214 Acylphosphatase; Region: Acylphosphatase; cl00551 471223001215 Sirohydrochlorin ferrochelatase [Inorganic ion transport and metabolism]; Region: COG2138 471223001216 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_N; cd03416 471223001217 putative active site [active] 471223001218 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), C-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_C; cd03414 471223001219 putative active site [active] 471223001220 Precorrin-3B methylase [Coenzyme metabolism]; Region: CobJ; cl00304 471223001221 Tetrapyrrole (Corrin/Porphyrin) Methylases; Region: TP_methylase; pfam00590 471223001222 DDE superfamily endonuclease; Region: DDE_5; cl02413 471223001223 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 471223001224 Archaeal putative transposase ISC1217; Region: DDE_Tnp_2; pfam04693 471223001225 Protein of unknown function (DUF3906); Region: DUF3906; pfam13046 471223001226 ferredoxin-nitrite reductase; Reviewed; Region: nirA; PRK09566 471223001227 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 471223001228 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 471223001229 Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically 'activated' sulfate form important for the assimilation of...; Region: APSK; cd02027 471223001230 AAA domain; Region: AAA_18; pfam13238 471223001231 ligand-binding site [chemical binding]; other site 471223001232 sulfate adenylyltransferase; Reviewed; Region: sat; PRK04149 471223001233 ATP-sulfurylase; Region: ATPS; cd00517 471223001234 active site 471223001235 HXXH motif; other site 471223001236 flexible loop; other site 471223001237 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 471223001238 Active Sites [active] 471223001239 PAS domain S-box; Region: sensory_box; TIGR00229 471223001240 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 471223001241 putative active site [active] 471223001242 heme pocket [chemical binding]; other site 471223001243 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 471223001244 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 471223001245 putative active site [active] 471223001246 heme pocket [chemical binding]; other site 471223001247 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 471223001248 dimer interface [polypeptide binding]; other site 471223001249 phosphorylation site [posttranslational modification] 471223001250 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 471223001251 ATP binding site [chemical binding]; other site 471223001252 Mg2+ binding site [ion binding]; other site 471223001253 G-X-G motif; other site 471223001254 Protein of unknown function (DUF1128); Region: DUF1128; cl11553 471223001255 Low molecular weight phosphatase family; Region: LMWPc; cd00115 471223001256 Low molecular weight phosphotyrosine protein phosphatase; Region: LMWPc; pfam01451 471223001257 active site 471223001258 YtxH-like protein; Region: YtxH; cl02079 471223001259 Virulence factor BrkB; Region: Virul_fac_BrkB; cl07918 471223001260 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 471223001261 Major Facilitator Superfamily; Region: MFS_1; pfam07690 471223001262 putative substrate translocation pore; other site 471223001263 calcium/proton exchanger (cax); Region: cax; TIGR00378 471223001264 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 471223001265 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 471223001266 YfkD-like protein; Region: YfkD; pfam14167 471223001267 Radical SAM superfamily; Region: Radical_SAM; pfam04055 471223001268 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 471223001269 FeS/SAM binding site; other site 471223001270 YfkB-like domain; Region: YfkB; pfam08756 471223001271 Fumarate hydratase (Fumerase); Region: Fumerase; cl00851 471223001272 Fumarase C-terminus; Region: Fumerase_C; cl00795 471223001273 Catalytic NodB homology domain of Bacillus subtilis polysaccharide deacetylase PdaA, and its bacterial homologs; Region: CE4_BsPdaA_like; cd10948 471223001274 delta-lactam-biosynthetic de-N-acetylase; Region: spore_pdaA; TIGR02884 471223001275 NodB motif; other site 471223001276 active site 471223001277 catalytic site [active] 471223001278 Cd binding site [ion binding]; other site 471223001279 3-methyladenine DNA glycosylase/8-oxoguanine DNA glycosylase [DNA replication, recombination, and repair]; Region: AlkA; COG0122 471223001280 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 471223001281 minor groove reading motif; other site 471223001282 helix-hairpin-helix signature motif; other site 471223001283 substrate binding pocket [chemical binding]; other site 471223001284 active site 471223001285 TRAM domain; Region: TRAM; cl01282 471223001286 23S rRNA (uracil-5-)-methyltransferase RumA; Region: rumA; TIGR00479 471223001287 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 471223001288 S-adenosylmethionine binding site [chemical binding]; other site 471223001289 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl15754 471223001290 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 471223001291 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 471223001292 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl15357 471223001293 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 471223001294 Cation transport protein; Region: TrkH; cl10514 471223001295 DDE superfamily endonuclease; Region: DDE_5; cl02413 471223001296 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 471223001297 Archaeal putative transposase ISC1217; Region: DDE_Tnp_2; pfam04693 471223001298 succinate CoA transferases; Region: YgfH_subfam; TIGR03458 471223001299 Acetyl-CoA hydrolase/transferase N-terminal domain; Region: AcetylCoA_hydro; pfam02550 471223001300 SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339 471223001301 LytTr DNA-binding domain; Region: LytTR; cl04498 471223001302 Domain of unknown function (DUF3870); Region: DUF3870; pfam12986 471223001303 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 471223001304 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 471223001305 active site 471223001306 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 471223001307 CoA-transferase family III; Region: CoA_transf_3; pfam02515 471223001308 NTF2-like N-terminal transpeptidase domain; Region: MecA_N; pfam05223 471223001309 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 471223001310 penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423 471223001311 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 471223001312 isocitrate dehydrogenase; Validated; Region: PRK09222 471223001313 Isocitrate/isopropylmalate dehydrogenase; Region: Iso_dh; cl00445 471223001314 peroxiredoxin; Region: AhpC; TIGR03137 471223001315 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 471223001316 dimer interface [polypeptide binding]; other site 471223001317 decamer (pentamer of dimers) interface [polypeptide binding]; other site 471223001318 catalytic triad [active] 471223001319 peroxidatic and resolving cysteines [active] 471223001320 alkyl hydroperoxide reductase subunit F; Provisional; Region: PRK15317 471223001321 Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) family, N-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which in turn catalyzes the reduction...; Region: AhpF_NTD_N; cd02974 471223001322 catalytic residue [active] 471223001323 TRX-GRX-like family, Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) subfamily, C-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which then...; Region: AhpF_NTD_C; cd03026 471223001324 catalytic residues [active] 471223001325 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 471223001326 A4GalT_like proteins catalyze the addition of galactose or glucose residues to the lipooligosaccharide (LOS) or lipopolysaccharide (LPS) of the bacterial cell surface; Region: GT8_A4GalT_like; cd04194 471223001327 Glycosyl transferase family 8; Region: Glyco_transf_8; pfam01501 471223001328 Ligand binding site; other site 471223001329 metal-binding site 471223001330 YfhD-like protein; Region: YfhD; pfam14151 471223001331 YfhE-like protein; Region: YfhE; pfam14152 471223001332 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 471223001333 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 471223001334 transposase, putative, N-terminal domain; Region: tspaseT_teng_N; TIGR01765 471223001335 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 471223001336 Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282 471223001337 RecX family; Region: RecX; cl00936 471223001338 Protein of unknown function (DUF1811); Region: DUF1811; pfam08838 471223001339 YpzG-like protein; Region: YpzG; pfam14139 471223001340 Small acid-soluble spore protein K family; Region: SspK; cl11509 471223001341 WVELL protein; Region: WVELL; pfam14043 471223001342 Predicted membrane-bound metal-dependent hydrolase (DUF457); Region: DUF457; cl00868 471223001343 Protein of unknown function (DUF1641); Region: DUF1641; cl01025 471223001344 Uncharacterized anaerobic dehydrogenase [General function prediction only]; Region: COG3383 471223001345 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 471223001346 catalytic loop [active] 471223001347 iron binding site [ion binding]; other site 471223001348 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; cl11210 471223001349 4Fe-4S binding domain; Region: Fer4; cl02805 471223001350 4Fe-4S binding domain; Region: Fer4; cl02805 471223001351 Formate dehydrogenase H (Formate-Dh-H) catalyzes the reversible oxidation of formate to CO2 with the release of a proton and two electrons. It is a component of the anaerobic formate hydrogen lyase complex. The E. coli formate dehydrogenase H (Fdh-H) is...; Region: MopB_Formate-Dh-H; cd02753 471223001352 [4Fe-4S] binding site [ion binding]; other site 471223001353 molybdopterin cofactor binding site; other site 471223001354 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_CT_Formate-Dh-Na-like; cd02792 471223001355 molybdopterin cofactor binding site; other site 471223001356 Uncharacterized conserved protein (DUF2294); Region: DUF2294; cl02390 471223001357 FdhD/NarQ family; Region: FdhD-NarQ; cl00659 471223001358 Oxalate/Formate Antiporter; Region: 2A0111; TIGR00890 471223001359 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 471223001360 putative substrate translocation pore; other site 471223001361 A/G-specific adenine glycosylase; Region: mutY; TIGR01084 471223001362 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 471223001363 minor groove reading motif; other site 471223001364 helix-hairpin-helix signature motif; other site 471223001365 substrate binding pocket [chemical binding]; other site 471223001366 active site 471223001367 Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; cl15304 471223001368 DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431 471223001369 DNA binding and oxoG recognition site [nucleotide binding] 471223001370 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 471223001371 1-cyclohexenylcarbonyl_coenzyme A_reductase (ChcA)_like, classical (c) SDRs; Region: ChcA_like_SDR_c; cd05359 471223001372 putative NAD(P) binding site [chemical binding]; other site 471223001373 active site 471223001374 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 471223001375 Probable transposase; Region: OrfB_IS605; pfam01385 471223001376 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 471223001377 Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282 471223001378 YgaB-like protein; Region: YgaB; pfam14182 471223001379 Protein of unknown function (DUF402); Region: DUF402; cl00979 471223001380 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 471223001381 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 471223001382 MsbA is an essential ABC transporter, closely related to eukaryotic MDR proteins. ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars, ions, peptides, and more complex organic...; Region: ABCC_MsbA; cd03251 471223001383 Walker A/P-loop; other site 471223001384 ATP binding site [chemical binding]; other site 471223001385 Q-loop/lid; other site 471223001386 ABC transporter signature motif; other site 471223001387 Walker B; other site 471223001388 D-loop; other site 471223001389 H-loop/switch region; other site 471223001390 Transposase DDE domain group 1; Region: DDE_Tnp_1_4; pfam13701 471223001391 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 471223001392 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 471223001393 Walker A/P-loop; other site 471223001394 ATP binding site [chemical binding]; other site 471223001395 Q-loop/lid; other site 471223001396 ABC transporter signature motif; other site 471223001397 Walker B; other site 471223001398 D-loop; other site 471223001399 H-loop/switch region; other site 471223001400 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 471223001401 dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308 471223001402 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 471223001403 Walker A/P-loop; other site 471223001404 ATP binding site [chemical binding]; other site 471223001405 Q-loop/lid; other site 471223001406 ABC transporter signature motif; other site 471223001407 Walker B; other site 471223001408 D-loop; other site 471223001409 H-loop/switch region; other site 471223001410 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 471223001411 The substrate-binding component of an ABC-type dipeptide import system contains the type 2 periplasmic binding fold; Region: PBP2_DppA_like; cd08493 471223001412 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 471223001413 peptide binding site [polypeptide binding]; other site 471223001414 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 471223001415 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 471223001416 dimer interface [polypeptide binding]; other site 471223001417 conserved gate region; other site 471223001418 putative PBP binding loops; other site 471223001419 ABC-ATPase subunit interface; other site 471223001420 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 471223001421 glutathione ABC transporter permease GsiD; Provisional; Region: PRK15082 471223001422 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 471223001423 dimer interface [polypeptide binding]; other site 471223001424 conserved gate region; other site 471223001425 ABC-ATPase subunit interface; other site 471223001426 Predicted membrane protein [Function unknown]; Region: COG4129 471223001427 Fusaric acid resistance protein-like; Region: FUSC_2; cl15844 471223001428 RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651 471223001429 Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078 471223001430 putative active site [active] 471223001431 putative NTP binding site [chemical binding]; other site 471223001432 putative nucleic acid binding site [nucleotide binding]; other site 471223001433 Group II intron, maturase-specific domain; Region: GIIM; pfam08388 471223001434 glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750 471223001435 Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713 471223001436 active site 471223001437 dimer interface [polypeptide binding]; other site 471223001438 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 471223001439 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 471223001440 active site 471223001441 FMN binding site [chemical binding]; other site 471223001442 substrate binding site [chemical binding]; other site 471223001443 3Fe-4S cluster binding site [ion binding]; other site 471223001444 GXGXG domain. This domain of unknown function is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS), in subunit C of tungsten formylmethanofuran dehydrogenase (FwdC) and in subunit C of molybdenum formylmethanofuran...; Region: GXGXG; cd00504 471223001445 domain_subunit interface; other site 471223001446 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK12389 471223001447 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 471223001448 inhibitor-cofactor binding pocket; inhibition site 471223001449 pyridoxal 5'-phosphate binding site [chemical binding]; other site 471223001450 catalytic residue [active] 471223001451 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4586 471223001452 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 471223001453 Walker A/P-loop; other site 471223001454 ATP binding site [chemical binding]; other site 471223001455 Q-loop/lid; other site 471223001456 ABC transporter signature motif; other site 471223001457 Walker B; other site 471223001458 D-loop; other site 471223001459 H-loop/switch region; other site 471223001460 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4587 471223001461 ABC-2 family transporter protein; Region: ABC2_membrane_6; cl01496 471223001462 ABC-2 family transporter protein; Region: ABC2_membrane_6; cl01496 471223001463 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4587 471223001464 L-lactate dehydrogenase; Reviewed; Region: ldh; PRK00066 471223001465 L-2-hydroxyisocapronate dehydrogenases and some bacterial L-lactate dehydrogenases; Region: HicDH_like; cd05291 471223001466 tetramer (dimer of dimers) interface [polypeptide binding]; other site 471223001467 NAD binding site [chemical binding]; other site 471223001468 dimer interface [polypeptide binding]; other site 471223001469 substrate binding site [chemical binding]; other site 471223001470 L-lactate permease; Region: Lactate_perm; cl00701 471223001471 glycolate transporter; Provisional; Region: PRK09695 471223001472 DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808 471223001473 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 471223001474 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 471223001475 Walker A/P-loop; other site 471223001476 ATP binding site [chemical binding]; other site 471223001477 Q-loop/lid; other site 471223001478 ABC transporter signature motif; other site 471223001479 Walker B; other site 471223001480 D-loop; other site 471223001481 H-loop/switch region; other site 471223001482 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 471223001483 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080 471223001484 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 471223001485 ATP binding site [chemical binding]; other site 471223001486 Mg2+ binding site [ion binding]; other site 471223001487 G-X-G motif; other site 471223001488 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 471223001489 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 471223001490 active site 471223001491 phosphorylation site [posttranslational modification] 471223001492 intermolecular recognition site; other site 471223001493 dimerization interface [polypeptide binding]; other site 471223001494 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 471223001495 DNA binding site [nucleotide binding] 471223001496 Ion channel; Region: Ion_trans_2; cl11596 471223001497 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 471223001498 catalytic triad [active] 471223001499 ferric uptake regulator; Provisional; Region: fur; PRK09462 471223001500 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 471223001501 metal binding site 2 [ion binding]; metal-binding site 471223001502 putative DNA binding helix; other site 471223001503 metal binding site 1 [ion binding]; metal-binding site 471223001504 dimer interface [polypeptide binding]; other site 471223001505 structural Zn2+ binding site [ion binding]; other site 471223001506 Protein of unknown function (DUF2614); Region: DUF2614; cl07936 471223001507 Uncharacterized protein family (UPF0236); Region: UPF0236; pfam06782 471223001508 B3/4 domain; Region: B3_4; cl11458 471223001509 Uncharacterized Fe-S protein [Energy production and conversion]; Region: COG1600 471223001510 Domain of unknown function (DUF1730); Region: DUF1730; pfam08331 471223001511 HEAT repeats; Region: HEAT_2; pfam13646 471223001512 PBS lyase HEAT-like repeat; Region: HEAT_PBS; cl15388 471223001513 NlpC/P60 family; Region: NLPC_P60; cl11438 471223001514 SpoU rRNA Methylase family; Region: SpoU_methylase; cl00362 471223001515 Putative Ser protein kinase [Signal transduction mechanisms]; Region: PrkA; COG2766 471223001516 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 471223001517 PrkA serine protein kinase C-terminal domain; Region: PrkA; pfam06798 471223001518 Transposase DDE domain group 1; Region: DDE_Tnp_1_4; pfam13701 471223001519 Uncharacterized conserved protein [Function unknown]; Region: COG2718 471223001520 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 471223001521 Transcriptional regulators [Transcription]; Region: PurR; COG1609 471223001522 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 471223001523 DNA binding site [nucleotide binding] 471223001524 domain linker motif; other site 471223001525 Ligand-binding domain of a novel transcription factor implicated in catabolite repression in Bacillus and Clostridium species; Region: PBP1_CcpB_like; cd06286 471223001526 putative ligand binding site [chemical binding]; other site 471223001527 putative dimerization interface [polypeptide binding]; other site 471223001528 Response regulator of citrate/malate metabolism [Transcription / Signal transduction mechanisms]; Region: CitB; COG4565 471223001529 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 471223001530 active site 471223001531 phosphorylation site [posttranslational modification] 471223001532 intermolecular recognition site; other site 471223001533 dimerization interface [polypeptide binding]; other site 471223001534 Helix-turn-helix domains; Region: HTH; cl00088 471223001535 Signal transduction histidine kinase regulating citrate/malate metabolism [Signal transduction mechanisms]; Region: CitA; COG3290 471223001536 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 471223001537 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 471223001538 ATP binding site [chemical binding]; other site 471223001539 Mg2+ binding site [ion binding]; other site 471223001540 G-X-G motif; other site 471223001541 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 471223001542 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441 471223001543 Sodium:dicarboxylate symporter family; Region: SDF; cl00573 471223001544 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 471223001545 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 471223001546 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 471223001547 active site 471223001548 catalytic tetrad [active] 471223001549 Putative neutral zinc metallopeptidase; Region: Zn_peptidase_2; cl01049 471223001550 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 471223001551 Domain of unknown function DUF21; Region: DUF21; pfam01595 471223001552 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 471223001553 Transporter associated domain; Region: CorC_HlyC; cl08393 471223001554 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 471223001555 PseudoU_synth_RsuA/RluD: Pseudouridine synthase, RsuA/RluD family. This group is comprised of eukaryotic, bacterial and archeal proteins similar to eight site specific Escherichia coli pseudouridine synthases: RsuA, RluA, RluB, RluC, RluD, RluE, RluF and...; Region: PseudoU_synth_RluCD_like; cd02869 471223001556 active site 471223001557 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 471223001558 catalytic residues [active] 471223001559 Disulfide bond formation protein DsbB; Region: DsbB; cl00649 471223001560 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 471223001561 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 471223001562 Ca binding site [ion binding]; other site 471223001563 active site 471223001564 catalytic site [active] 471223001565 FOG: CBS domain [General function prediction only]; Region: COG0517 471223001566 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_9; cd04622 471223001567 phosphoglucomutase-2-like protein; Provisional; Region: PTZ00150 471223001568 This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...; Region: PGM2; cd05799 471223001569 active site 471223001570 substrate binding site [chemical binding]; other site 471223001571 metal binding site [ion binding]; metal-binding site 471223001572 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 471223001573 transposase, putative, N-terminal domain; Region: tspaseT_teng_N; TIGR01765 471223001574 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 471223001575 Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282 471223001576 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 471223001577 YhdB-like protein; Region: YhdB; pfam14148 471223001578 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 471223001579 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 471223001580 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 471223001581 Predicted transcriptional regulator containing an HTH domain and an uncharacterized domain shared with the mammalian protein Schlafen [Transcription]; Region: COG2865 471223001582 Divergent AAA domain; Region: AAA_4; pfam04326 471223001583 ATP-dependent DNA helicase recG C-terminal; Region: HATPase_c_4; pfam13749 471223001584 Protein of unknown function (DUF1407); Region: DUF1407; pfam07191 471223001585 Integrase core domain; Region: rve; cl01316 471223001586 DDE domain; Region: DDE_Tnp_IS240; pfam13610 471223001587 Integrase core domain; Region: rve_3; cl15866 471223001588 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3328 471223001589 Protein of unknown function with PCYCGC motif; Region: PCYCGC; pfam13798 471223001590 Predicted divalent heavy-metal cations transporter [Inorganic ion transport and metabolism]; Region: COG0428; cl00437 471223001591 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 471223001592 dimerization interface [polypeptide binding]; other site 471223001593 putative DNA binding site [nucleotide binding]; other site 471223001594 putative Zn2+ binding site [ion binding]; other site 471223001595 Cation efflux family; Region: Cation_efflux; cl00316 471223001596 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 471223001597 flavin-dependent oxidoreductase, MSMEG_0569 family; Region: MSMEG_0569_nitr; TIGR04046 471223001598 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 471223001599 flavin-dependent oxidoreductase, MSMEG_0569 family; Region: MSMEG_0569_nitr; TIGR04046 471223001600 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 471223001601 dimerization interface [polypeptide binding]; other site 471223001602 putative DNA binding site [nucleotide binding]; other site 471223001603 putative Zn2+ binding site [ion binding]; other site 471223001604 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 471223001605 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 471223001606 metal-binding site [ion binding] 471223001607 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 471223001608 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 471223001609 Uncharacterized conserved protein [Function unknown]; Region: SpoVR; COG2719 471223001610 SpoVR like protein; Region: SpoVR; pfam04293 471223001611 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; cl00562 471223001612 Cytochrome bd-type quinol oxidase, subunit 2 [Energy production and conversion]; Region: AppB; COG1294 471223001613 DsrE/DsrF-like family; Region: DrsE; cl00672 471223001614 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 471223001615 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 471223001616 S-adenosylmethionine binding site [chemical binding]; other site 471223001617 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 471223001618 active site residue [active] 471223001619 Uncharacterized protein YrkD from Bacillus subtilis and related domains; this domain superfamily was previously known as part of DUF156; Region: BsYrkD-like_DUF156; cd10155 471223001620 putative homotetramer interface [polypeptide binding]; other site 471223001621 putative homodimer interface [polypeptide binding]; other site 471223001622 putative metal binding site [ion binding]; other site 471223001623 putative homodimer-homodimer interface [polypeptide binding]; other site 471223001624 putative allosteric switch controlling residues; other site 471223001625 SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain. SirA (also known as UvrY, and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291 471223001626 CPxP motif; other site 471223001627 DsrE/DsrF-like family; Region: DrsE; cl00672 471223001628 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 471223001629 active site residue [active] 471223001630 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 471223001631 active site residue [active] 471223001632 SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain. SirA (also known as UvrY, and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291 471223001633 CPxP motif; other site 471223001634 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 471223001635 active site residue [active] 471223001636 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 471223001637 active site residue [active] 471223001638 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 471223001639 SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain. SirA (also known as UvrY, and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291 471223001640 CPxP motif; other site 471223001641 Predicted permeases [General function prediction only]; Region: COG0730; cl00498 471223001642 formaldehyde dehydrogenase (FDH)-like; Region: FDH_like_ADH2; cd08286 471223001643 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 471223001644 catalytic Zn binding site [ion binding]; other site 471223001645 structural Zn binding site [ion binding]; other site 471223001646 NAD(P) binding site [chemical binding]; other site 471223001647 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 471223001648 dimerization interface [polypeptide binding]; other site 471223001649 putative DNA binding site [nucleotide binding]; other site 471223001650 putative Zn2+ binding site [ion binding]; other site 471223001651 luciferase-type oxidoreductase, BA3436 family; Region: lucif_BA3436; TIGR03571 471223001652 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 471223001653 Coenzyme A acylating aldehyde dehydrogenase (ACDH), ALDH family 20-like; Region: ALDH_F20_ACDH; cd07122 471223001654 putative catalytic cysteine [active] 471223001655 Domain of unknown function (DUF4277); Region: DUF4277; pfam14104 471223001656 Transposase [DNA replication, recombination, and repair]; Region: COG5421 471223001657 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 471223001658 nudix motif; other site 471223001659 Transposase domain (DUF772); Region: DUF772; cl15789 471223001660 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 471223001661 Transposase domain (DUF772); Region: DUF772; cl15789 471223001662 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 471223001663 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 471223001664 Walker A/P-loop; other site 471223001665 ATP binding site [chemical binding]; other site 471223001666 Q-loop/lid; other site 471223001667 ABC transporter signature motif; other site 471223001668 Walker B; other site 471223001669 D-loop; other site 471223001670 H-loop/switch region; other site 471223001671 This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002 471223001672 putative deacylase active site [active] 471223001673 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 471223001674 transposase, putative, N-terminal domain; Region: tspaseT_teng_N; TIGR01765 471223001675 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 471223001676 Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282 471223001677 transposase, putative, N-terminal domain; Region: tspaseT_teng_N; TIGR01765 471223001678 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 471223001679 Small Multidrug Resistance protein; Region: Multi_Drug_Res; cl00910 471223001680 Domain of unknown function (DUF4179); Region: DUF4179; pfam13786 471223001681 RNA polymerase sigma factor; Provisional; Region: PRK11924 471223001682 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 471223001683 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 471223001684 DNA binding residues [nucleotide binding] 471223001685 Antibiotic biosynthesis monooxygenase; Region: ABM; cl10022 471223001686 EamA-like transporter family; Region: EamA; cl01037 471223001687 Protein of unknown function (DUF1232); Region: DUF1232; cl01318 471223001688 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 471223001689 dimer interface [polypeptide binding]; other site 471223001690 putative radical transfer pathway; other site 471223001691 diiron center [ion binding]; other site 471223001692 tyrosyl radical; other site 471223001693 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK09209 471223001694 Class I ribonucleotide reductase; Region: RNR_I; cd01679 471223001695 active site 471223001696 dimer interface [polypeptide binding]; other site 471223001697 catalytic residues [active] 471223001698 effector binding site; other site 471223001699 R2 peptide binding site; other site 471223001700 carbon starvation protein A; Provisional; Region: PRK15015 471223001701 Carbon starvation protein CstA; Region: CstA; pfam02554 471223001702 C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722 471223001703 Protein of unknown function (DUF466); Region: DUF466; cl01082 471223001704 2-dehydropantoate 2-reductase; Provisional; Region: PRK12921 471223001705 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 471223001706 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 471223001707 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 471223001708 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 471223001709 Ca binding site [ion binding]; other site 471223001710 active site 471223001711 catalytic site [active] 471223001712 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; cl00986 471223001713 DinB superfamily; Region: DinB_2; pfam12867 471223001714 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 471223001715 major facilitator superfamily transporter; Provisional; Region: PRK05122 471223001716 putative substrate translocation pore; other site 471223001717 Predicted SAM-dependent methyltransferases [General function prediction only]; Region: COG1092 471223001718 PUA domain; Region: PUA; cl00607 471223001719 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 471223001720 S-adenosylmethionine binding site [chemical binding]; other site 471223001721 Heme oxygenase catalyzes the rate limiting step in the degradation of heme to bilirubin, it is essential for recycling of iron from heme. Heme is used as a substrate and cofactor for its own degradation to biliverdin, iron, and carbon monoxide. This...; Region: HemeO; cl15243 471223001722 ABC-type cobalt transport system, permease component; Region: ABC_cobalt; cl01943 471223001723 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 471223001724 Domain I of the ABC component of a cobalt transport family found in bacteria, archaea, and eukaryota. The transition metal cobalt is an essential component of many enzymes and must be transported into cells in appropriate amounts when needed. This ABC...; Region: ABC_cobalt_CbiO_domain1; cd03225 471223001725 Walker A/P-loop; other site 471223001726 ATP binding site [chemical binding]; other site 471223001727 Q-loop/lid; other site 471223001728 ABC transporter signature motif; other site 471223001729 Walker B; other site 471223001730 D-loop; other site 471223001731 H-loop/switch region; other site 471223001732 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 471223001733 Domain I of the ABC component of a cobalt transport family found in bacteria, archaea, and eukaryota. The transition metal cobalt is an essential component of many enzymes and must be transported into cells in appropriate amounts when needed. This ABC...; Region: ABC_cobalt_CbiO_domain1; cd03225 471223001734 Walker A/P-loop; other site 471223001735 ATP binding site [chemical binding]; other site 471223001736 Q-loop/lid; other site 471223001737 ABC transporter signature motif; other site 471223001738 Walker B; other site 471223001739 D-loop; other site 471223001740 H-loop/switch region; other site 471223001741 Cobalt transport protein; Region: CbiQ; cl00463 471223001742 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 471223001743 thiamine phosphate binding site [chemical binding]; other site 471223001744 active site 471223001745 pyrophosphate binding site [ion binding]; other site 471223001746 ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565 471223001747 thiS-thiF/thiG interaction site; other site 471223001748 Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728 471223001749 ThiS interaction site; other site 471223001750 putative active site [active] 471223001751 tetramer interface [polypeptide binding]; other site 471223001752 thiamine/molybdopterin biosynthesis ThiF/MoeB-like protein; Validated; Region: PRK07688 471223001753 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 471223001754 ATP binding site [chemical binding]; other site 471223001755 substrate interface [chemical binding]; other site 471223001756 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 471223001757 transposase, putative, N-terminal domain; Region: tspaseT_teng_N; TIGR01765 471223001758 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 471223001759 Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282 471223001760 Domain of unknown function DUF21; Region: DUF21; pfam01595 471223001761 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 471223001762 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 471223001763 Transporter associated domain; Region: CorC_HlyC; cl08393 471223001764 Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269 471223001765 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 471223001766 The N-terminal ATPase domain of the maltose transporter, MalK. ATP binding cassette (ABC) proteins function from bacteria to human, mediating the translocation of substances into and out of cells or organelles. ABC transporters contain two...; Region: ABC_MalK_N; cd03301 471223001767 Walker A/P-loop; other site 471223001768 ATP binding site [chemical binding]; other site 471223001769 Q-loop/lid; other site 471223001770 ABC transporter signature motif; other site 471223001771 Walker B; other site 471223001772 D-loop; other site 471223001773 H-loop/switch region; other site 471223001774 TOBE domain; Region: TOBE_2; cl01440 471223001775 Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508 471223001776 Helix-turn-helix domains; Region: HTH; cl00088 471223001777 ATP-grasp domain; Region: ATP-grasp_4; cl03087 471223001778 ATP-grasp domain; Region: ATP-grasp_4; cl03087 471223001779 ATP-grasp domain; Region: ATP-grasp_4; cl03087 471223001780 Sugar-transfer associated ATP-grasp; Region: ATPgrasp_ST; pfam14397 471223001781 ATP-grasp domain; Region: ATP-grasp_4; cl03087 471223001782 Protein of unknown function (DUF964); Region: DUF964; cl01483 471223001783 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 471223001784 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 471223001785 coproporphyrinogen III oxidase; Provisional; Region: PRK08207 471223001786 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 471223001787 FeS/SAM binding site; other site 471223001788 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 471223001789 transposase, putative, N-terminal domain; Region: tspaseT_teng_N; TIGR01765 471223001790 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 471223001791 Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282 471223001792 YhzD-like protein; Region: YhzD; pfam14120 471223001793 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4152 471223001794 This subfamily is involved in drug resistance, nodulation, lipid transport, and bacteriocin and lantibiotic immunity. In eubacteria and archaea, the typical organization consists of one ABC and one or two IMs. Eukaryote systems of the ABCA subfamily...; Region: ABC_putative_ATPase; cd03269 471223001795 Walker A/P-loop; other site 471223001796 ATP binding site [chemical binding]; other site 471223001797 Q-loop/lid; other site 471223001798 ABC transporter signature motif; other site 471223001799 Walker B; other site 471223001800 D-loop; other site 471223001801 H-loop/switch region; other site 471223001802 Domain of unknown function (DUF4162); Region: DUF4162; pfam13732 471223001803 ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668 471223001804 ABC-2 type transporter; Region: ABC2_membrane; cl11417 471223001805 3'-5' exoribonuclease YhaM; Provisional; Region: PRK13480 471223001806 YhaM_OBF_like: A subfamily of OB folds similar to that found in Bacillus subtilis YhaM and Staphylococcus aureus cmp-binding factor-1 (SaCBF1). Both these proteins are 3'-to-5'exoribonucleases. YhaM requires Mn2+ or Co2+ for activity and is inactive in...; Region: YhaM_OBF_like; cd04492 471223001807 generic binding surface II; other site 471223001808 generic binding surface I; other site 471223001809 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 471223001810 Zn2+ binding site [ion binding]; other site 471223001811 Mg2+ binding site [ion binding]; other site 471223001812 Sporulation protein YhaL; Region: Spore_YhaL; pfam14147 471223001813 Phosphoserine aminotransferase (PSAT) family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major group in this CD corresponds to phosphoserine aminotransferase (PSAT). PSAT is active as...; Region: PSAT_like; cd00611 471223001814 homodimer interface [polypeptide binding]; other site 471223001815 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 471223001816 substrate-cofactor binding pocket; other site 471223001817 pyridoxal 5'-phosphate binding site [chemical binding]; other site 471223001818 catalytic residue [active] 471223001819 transcriptional regulator Hpr; Provisional; Region: PRK13777 471223001820 Helix-turn-helix domains; Region: HTH; cl00088 471223001821 Protein of unknown function (DUF1878); Region: DUF1878; pfam08963 471223001822 peptidylprolyl isomerase; Reviewed; Region: prsA; PRK03095 471223001823 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 471223001824 PPIC-type PPIASE domain; Region: Rotamase; cl08278 471223001825 HINT (histidine triad nucleotide-binding protein) subgroup: Members of this CD belong to the superfamily of histidine triad hydrolases that act on alpha-phosphate of ribonucleotides. This subgroup includes members from all three forms of cellular life; Region: HINT_subgroup; cd01277 471223001826 HIT family signature motif; other site 471223001827 catalytic residue [active] 471223001828 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 471223001829 This family of ATP-binding proteins belongs to a multisubunit transporter involved in drug resistance (BcrA and DrrA), nodulation, lipid transport, and lantibiotic immunity. In bacteria and archaea, these transporters usually include an ATP-binding...; Region: ABC_DR_subfamily_A; cd03230 471223001830 Walker A/P-loop; other site 471223001831 ATP binding site [chemical binding]; other site 471223001832 Q-loop/lid; other site 471223001833 ABC transporter signature motif; other site 471223001834 Walker B; other site 471223001835 D-loop; other site 471223001836 H-loop/switch region; other site 471223001837 Bacterial ABC transporter protein EcsB; Region: EcsB; cl11542 471223001838 Antibiotic biosynthesis monooxygenase; Region: ABM; cl10022 471223001839 Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717 471223001840 methyltransferase, MtaA/CmuA family; Region: mtaA_cmuA; TIGR01463 471223001841 substrate binding site [chemical binding]; other site 471223001842 active site 471223001843 ferrochelatase; Provisional; Region: PRK12435 471223001844 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 471223001845 C-terminal domain interface [polypeptide binding]; other site 471223001846 active site 471223001847 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 471223001848 active site 471223001849 N-terminal domain interface [polypeptide binding]; other site 471223001850 protoporphyrinogen oxidase; Reviewed; Region: PRK11883 471223001851 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 471223001852 Helix-turn-helix domains; Region: HTH; cl00088 471223001853 Predicted membrane protein [Function unknown]; Region: COG1511 471223001854 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 471223001855 X-X-X-Leu-X-X-Gly heptad repeats; Region: xxxLxxG_by_4; TIGR03057 471223001856 X-X-X-Leu-X-X-Gly heptad repeats; Region: xxxLxxG_by_4; TIGR03057 471223001857 X-X-X-Leu-X-X-Gly heptad repeats; Region: xxxLxxG_by_4; TIGR03057 471223001858 X-X-X-Leu-X-X-Gly heptad repeats; Region: xxxLxxG_by_4; TIGR03057 471223001859 ABC-2 type transporter; Region: ABC2_membrane; cl11417 471223001860 YhfH-like protein; Region: YhfH; pfam14149 471223001861 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 471223001862 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07656 471223001863 AMP-binding enzyme; Region: AMP-binding; cl15778 471223001864 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 471223001865 Type I periplasmic ligand-binding domain of uncharacterized ABC-type transport systems that are predicted to be involved in the uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_uncharacterized_transporter; cd06325 471223001866 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 471223001867 zinc binding site [ion binding]; other site 471223001868 putative ligand binding site [chemical binding]; other site 471223001869 Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cd06574 471223001870 TM-ABC transporter signature motif; other site 471223001871 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: PhnK; COG1101 471223001872 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 471223001873 Walker A/P-loop; other site 471223001874 ATP binding site [chemical binding]; other site 471223001875 Q-loop/lid; other site 471223001876 ABC transporter signature motif; other site 471223001877 Walker B; other site 471223001878 D-loop; other site 471223001879 H-loop/switch region; other site 471223001880 D-Alanine aminotransferase (D-AAT_like): D-amino acid aminotransferase catalyzes transamination between D-amino acids and their respective alpha-keto acids. It plays a major role in the synthesis of bacterial cell wall components like D-alanine and...; Region: D-AAT_like; cd01558 471223001881 homodimer interface [polypeptide binding]; other site 471223001882 substrate-cofactor binding pocket; other site 471223001883 pyridoxal 5'-phosphate binding site [chemical binding]; other site 471223001884 catalytic residue [active] 471223001885 AzlC protein; Region: AzlC; cl00570 471223001886 Branched-chain amino acid transport protein (AzlD); Region: AzlD; cl00735 471223001887 SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968 471223001888 Cu(I) binding site [ion binding]; other site 471223001889 PEP phosphonomutase and related enzymes [Carbohydrate transport and metabolism]; Region: PrpB; COG2513 471223001890 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 471223001891 tetramer interface [polypeptide binding]; other site 471223001892 active site 471223001893 Mg2+/Mn2+ binding site [ion binding]; other site 471223001894 ComK protein; Region: ComK; cl11560 471223001895 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 471223001896 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 471223001897 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 471223001898 Catalytic site [active] 471223001899 helicase-exonuclease AddAB, AddB subunit; Region: addB_Gpos; TIGR02773 471223001900 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641 471223001901 helicase-exonuclease AddAB, AddA subunit, Firmicutes type; Region: addA_Gpos; TIGR02785 471223001902 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 471223001903 Family description; Region: UvrD_C_2; cl15862 471223001904 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641 471223001905 DNA repair exonuclease [DNA replication, recombination, and repair]; Region: SbcD; COG0420 471223001906 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 471223001907 active site 471223001908 metal binding site [ion binding]; metal-binding site 471223001909 DNA binding site [nucleotide binding] 471223001910 Type 5 capsule protein repressor C-terminal domain; Region: SbcD_C; pfam12320 471223001911 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: SbcC; COG0419 471223001912 SbcCD and other Mre11/Rad50 (MR) complexes are implicated in the metabolism of DNA ends. They cleave ends sealed by hairpin structures and are thought to play a role in removing protein bound to DNA termini; Region: ABC_sbcCD; cd03279 471223001913 Walker A/P-loop; other site 471223001914 ATP binding site [chemical binding]; other site 471223001915 Q-loop/lid; other site 471223001916 ABC transporter signature motif; other site 471223001917 exonuclease SbcC; Region: sbcc; TIGR00618 471223001918 SbcCD and other Mre11/Rad50 (MR) complexes are implicated in the metabolism of DNA ends. They cleave ends sealed by hairpin structures and are thought to play a role in removing protein bound to DNA termini; Region: ABC_sbcCD; cd03279 471223001919 Q-loop/lid; other site 471223001920 ABC transporter signature motif; other site 471223001921 Walker B; other site 471223001922 D-loop; other site 471223001923 H-loop/switch region; other site 471223001924 Spore germination protein gerPA/gerPF; Region: gerPA; pfam10676 471223001925 Protein of unknown function (DUF2772); Region: DUF2772; pfam10970 471223001926 Spore germination protein GerPC; Region: GerPC; pfam10737 471223001927 Protein of unknown function (DUF2539); Region: DUF2539; pfam10803 471223001928 Spore germination protein gerPA/gerPF; Region: gerPA; pfam10676 471223001929 Spore germination protein gerPA/gerPF; Region: gerPA; pfam10676 471223001930 Spore germination protein gerPA/gerPF; Region: gerPA; pfam10676 471223001931 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187 471223001932 AMP-binding enzyme; Region: AMP-binding; cl15778 471223001933 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 471223001934 Predicted membrane protein [Function unknown]; Region: COG2311 471223001935 Protein of unknown function (DUF418); Region: DUF418; cl12135 471223001936 Protein of unknown function (DUF418); Region: DUF418; cl12135 471223001937 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 471223001938 ornithine--oxo-acid transaminase; Provisional; Region: rocD; PRK04073 471223001939 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 471223001940 inhibitor-cofactor binding pocket; inhibition site 471223001941 pyridoxal 5'-phosphate binding site [chemical binding]; other site 471223001942 catalytic residue [active] 471223001943 Protein of unknown function (DUF1516); Region: DUF1516; cl11654 471223001944 FIST N domain; Region: FIST; cl10701 471223001945 FIST C domain; Region: FIST_C; pfam10442 471223001946 PAS domain S-box; Region: sensory_box; TIGR00229 471223001947 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 471223001948 putative active site [active] 471223001949 heme pocket [chemical binding]; other site 471223001950 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 471223001951 metal binding site [ion binding]; metal-binding site 471223001952 active site 471223001953 I-site; other site 471223001954 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 471223001955 Protein of unknown function (DUF2777); Region: DUF2777; pfam10949 471223001956 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 471223001957 active site 471223001958 asparagine synthase (glutamine-hydrolyzing); Region: asn_synth_AEB; TIGR01536 471223001959 dimer interface [polypeptide binding]; other site 471223001960 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 471223001961 Ligand Binding Site [chemical binding]; other site 471223001962 Molecular Tunnel; other site 471223001963 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 471223001964 MatE; Region: MatE; cl10513 471223001965 MatE; Region: MatE; cl10513 471223001966 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 471223001967 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 471223001968 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 471223001969 maltodextrin glucosidase; Provisional; Region: PRK10785 471223001970 N-terminal Early set domain associated with the catalytic domain of cyclomaltodextrinase and pullulan-degrading enzymes; Region: E_set_CDase_PDE_N; cd02857 471223001971 homodimer interface [polypeptide binding]; other site 471223001972 Alpha amylase catalytic domain found in cyclomaltodextrinases and related proteins; Region: AmyAc_CMD; cd11338 471223001973 active site 471223001974 homodimer interface [polypeptide binding]; other site 471223001975 catalytic site [active] 471223001976 Protein of unknown function (DUF1407); Region: DUF1407; pfam07191 471223001977 Integrase core domain; Region: rve; cl01316 471223001978 DDE domain; Region: DDE_Tnp_IS240; pfam13610 471223001979 Integrase core domain; Region: rve_3; cl15866 471223001980 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 471223001981 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 471223001982 dimer interface [polypeptide binding]; other site 471223001983 conserved gate region; other site 471223001984 putative PBP binding loops; other site 471223001985 ABC-ATPase subunit interface; other site 471223001986 ABC-type maltose transport systems, permease component [Carbohydrate transport and metabolism]; Region: MalG; COG3833 471223001987 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 471223001988 dimer interface [polypeptide binding]; other site 471223001989 conserved gate region; other site 471223001990 putative PBP binding loops; other site 471223001991 ABC-ATPase subunit interface; other site 471223001992 trehalose synthase; Region: treS_nterm; TIGR02456 471223001993 Alpha amylase catalytic domain found in bacterial cyclomaltodextrinases and related proteins; Region: AmyAc_bac_CMD_like_2; cd11339 471223001994 active site 471223001995 catalytic site [active] 471223001996 Transcriptional regulators [Transcription]; Region: PurR; COG1609 471223001997 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 471223001998 DNA binding site [nucleotide binding] 471223001999 domain linker motif; other site 471223002000 Ligand-binding domain of uncharacterized transcription regulator ycjW which is a member of the LacI-GalR family repressors; Region: PBP1_ycjW_transcription_regulator_like; cd06294 471223002001 putative dimerization interface [polypeptide binding]; other site 471223002002 putative ligand binding site [chemical binding]; other site 471223002003 Alpha amylase catalytic domain found in maltogenic amylases, cyclodextrin glycosyltransferase, and related proteins; Region: AmyAc_AmyMalt_CGTase_like; cd11320 471223002004 Ca binding site [ion binding]; other site 471223002005 active site 471223002006 catalytic site [active] 471223002007 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; cl02706 471223002008 IPT domain (domain D) of cyclodextrin glycosyltransferase (CGTase) and similar enzymes. These enzymes are involved in the enzymatic hydrolysis of alpha-1,4 linkages of starch polymers and belong to the glycosyl hydrolase family 13. Most consist of three...; Region: IPT_CGTD; cd00604 471223002009 The family 20 carbohydrate-binding module (CBM20), also known as the starch-binding domain, is found in a large number of starch degrading enzymes including alpha-amylase, beta-amylase, glucoamylase, and CGTase (cyclodextrin glucanotransferase). CBM20 is...; Region: CBM20; cl15347 471223002010 starch-binding site 2 [chemical binding]; other site 471223002011 starch-binding site 1 [chemical binding]; other site 471223002012 Maltose-binding periplasmic proteins/domains [Carbohydrate transport and metabolism]; Region: MalE; COG2182 471223002013 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 471223002014 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 471223002015 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 471223002016 dimer interface [polypeptide binding]; other site 471223002017 conserved gate region; other site 471223002018 putative PBP binding loops; other site 471223002019 ABC-ATPase subunit interface; other site 471223002020 ABC-type maltose transport systems, permease component [Carbohydrate transport and metabolism]; Region: MalG; COG3833 471223002021 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 471223002022 dimer interface [polypeptide binding]; other site 471223002023 conserved gate region; other site 471223002024 putative PBP binding loops; other site 471223002025 ABC-ATPase subunit interface; other site 471223002026 putative alpha-glucosidase; Provisional; Region: PRK10658 471223002027 Galactose mutarotase-like; Region: Gal_mutarotas_2; pfam13802 471223002028 CtsZ (cyclic tetrasaccharide-synthesizing enzyme Z) is a bacterial 6-alpha-glucosyltransferase, first identified in Arthrobacter globiformis, that produces cyclic tetrasaccharides together with a closely related enzyme CtsY. CtsZ and CtsY both have a...; Region: GH31_transferase_CtsZ; cd06598 471223002029 putative active site [active] 471223002030 putative catalytic site [active] 471223002031 short chain dehydrogenase; Provisional; Region: PRK06701 471223002032 classical (c) SDR, subgroup 1; Region: SDR_c1; cd05355 471223002033 NAD binding site [chemical binding]; other site 471223002034 metal binding site [ion binding]; metal-binding site 471223002035 active site 471223002036 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; cl14105 471223002037 5-methyltetrahydrofolate--homocysteine methyltransferase; Region: metH; TIGR02082 471223002038 Pterin binding enzymes. This family includes dihydropteroate synthase (DHPS) and cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). DHPS, a...; Region: Pterin_binding; cl00219 471223002039 substrate binding pocket [chemical binding]; other site 471223002040 dimer interface [polypeptide binding]; other site 471223002041 inhibitor binding site; inhibition site 471223002042 B12 binding domain of methionine synthase. This domain binds methylcobalamin, which it uses as an intermediate methyl carrier from methyltetrahydrofolate (CH3H4folate) to homocysteine (Hcy); Region: methionine_synthase_B12_BD; cd02069 471223002043 B12 binding site [chemical binding]; other site 471223002044 cobalt ligand [ion binding]; other site 471223002045 Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965 471223002046 bifunctional homocysteine S-methyltransferase/5,10-methylenetetrahydrofolate reductase protein; Reviewed; Region: PRK08645 471223002047 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; cl14105 471223002048 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 471223002049 FAD binding site [chemical binding]; other site 471223002050 Protein of unknown function (DUF520); Region: DUF520; cl00723 471223002051 Predicted RNA-bindining protein (contains S1 and HTH domains) [General function prediction only]; Region: COG2996 471223002052 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 471223002053 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 471223002054 Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744 471223002055 Periplasmic binding domain of basic membrane lipoprotein, PnrA, in Treponema pallidum and its homologs from other bacteria and Archaea; Region: PBP1_BmpA_PnrA_like; cd06354 471223002056 ligand binding site [chemical binding]; other site 471223002057 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 471223002058 nitrate/nitrite sensor protein NarQ; Provisional; Region: PRK10935 471223002059 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 471223002060 dimerization interface [polypeptide binding]; other site 471223002061 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 471223002062 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 471223002063 dimer interface [polypeptide binding]; other site 471223002064 putative CheW interface [polypeptide binding]; other site 471223002065 Uncharacterized protein, DegV family COG1307; Region: DegV; cl00577 471223002066 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 471223002067 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 471223002068 motif II; other site 471223002069 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 471223002070 esterase; Provisional; Region: PRK10566 471223002071 Domain of unknown function DUF59; Region: DUF59; cl00941 471223002072 SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain. SirA (also known as UvrY, and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cl00436 471223002073 molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317 471223002074 MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503 471223002075 GTP binding site; other site 471223002076 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 471223002077 Probable transposase; Region: OrfB_IS605; pfam01385 471223002078 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 471223002079 Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282 471223002080 Transposase; Region: DEDD_Tnp_IS110; pfam01548 471223002081 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 471223002082 molybdenum cofactor biosynthesis protein A, bacterial; Region: moaA; TIGR02666 471223002083 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 471223002084 FeS/SAM binding site; other site 471223002085 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 471223002086 Domain of unknown function (DUF1858); Region: DUF1858; cl14817 471223002087 iron-sulfur cluster repair di-iron protein; Region: FeS_repair_RIC; TIGR03652 471223002088 Hemerythrin (Hr) is a non-heme diiron oxygen transport protein found in four marine invertebrate phyla including priapulida, brachiopoda, sipunculida, and annelida, as well as in protozoa. Myohemerythrin (Mhr), a hemerythrin homolog, is found in the...; Region: Hemerythrin; cl15774 471223002089 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 471223002090 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 471223002091 dimer interface [polypeptide binding]; other site 471223002092 putative functional site; other site 471223002093 putative MPT binding site; other site 471223002094 Molybdenum is an essential trace element in the form of molybdenum cofactor (Moco) which is associated with the metabolism of nitrogen, carbon and sulfur by redox active enzymes. In E. coli, the synthesis of Moco involves genes from several loci: moa; Region: MobB; cd03116 471223002095 Walker A motif; other site 471223002096 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 471223002097 MoaE homodimer interface [polypeptide binding]; other site 471223002098 MoaD interaction [polypeptide binding]; other site 471223002099 active site residues [active] 471223002100 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 471223002101 MoaE interaction surface [polypeptide binding]; other site 471223002102 MoeB interaction surface [polypeptide binding]; other site 471223002103 thiocarboxylated glycine; other site 471223002104 YwiC-like protein; Region: YwiC; pfam14256 471223002105 N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436 471223002106 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 471223002107 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; cl15856 471223002108 Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152 471223002109 heterotetramer interface [polypeptide binding]; other site 471223002110 active site pocket [active] 471223002111 cleavage site 471223002112 AAK_NAGK-like: N-Acetyl-L-glutamate kinase (NAGK)-like . Included in this CD are the Escherichia coli and Pseudomonas aeruginosa type NAGKs which catalyze the phosphorylation of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine...; Region: AAK_NAGK-like; cd04238 471223002113 nucleotide binding site [chemical binding]; other site 471223002114 N-acetyl-L-glutamate binding site [chemical binding]; other site 471223002115 acetylornithine aminotransferase; Provisional; Region: argD; PRK02936 471223002116 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 471223002117 inhibitor-cofactor binding pocket; inhibition site 471223002118 pyridoxal 5'-phosphate binding site [chemical binding]; other site 471223002119 catalytic residue [active] 471223002120 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12838 471223002121 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; cl03056 471223002122 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 471223002123 catalytic site [active] 471223002124 subunit interface [polypeptide binding]; other site 471223002125 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK12815 471223002126 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 471223002127 ATP-grasp domain; Region: ATP-grasp_4; cl03087 471223002128 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 471223002129 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 471223002130 ATP-grasp domain; Region: ATP-grasp_4; cl03087 471223002131 ornithine carbamoyltransferase; Provisional; Region: PRK00779 471223002132 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 471223002133 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 471223002134 YjzC-like protein; Region: YjzC; pfam14168 471223002135 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 471223002136 Clp amino terminal domain; Region: Clp_N; pfam02861 471223002137 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 471223002138 Walker A motif; other site 471223002139 ATP binding site [chemical binding]; other site 471223002140 Walker B motif; other site 471223002141 arginine finger; other site 471223002142 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 471223002143 Walker A motif; other site 471223002144 ATP binding site [chemical binding]; other site 471223002145 Walker B motif; other site 471223002146 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; cl11083 471223002147 Protein of unknown function (DUF2929); Region: DUF2929; pfam11151 471223002148 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 471223002149 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 471223002150 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 471223002151 dimer interface [polypeptide binding]; other site 471223002152 active site 471223002153 CoA binding pocket [chemical binding]; other site 471223002154 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 471223002155 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 471223002156 dimer interface [polypeptide binding]; other site 471223002157 active site 471223002158 Predicted Zn-dependent protease (DUF2268); Region: DUF2268; cl02316 471223002159 Protein of unknown function (DUF3603); Region: DUF3603; pfam12227 471223002160 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 471223002161 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 471223002162 active site 471223002163 HIGH motif; other site 471223002164 dimer interface [polypeptide binding]; other site 471223002165 KMSKS motif; other site 471223002166 Domain of unknown function (DUF3899); Region: DUF3899; pfam13038 471223002167 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 471223002168 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 471223002169 peptide binding site [polypeptide binding]; other site 471223002170 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 471223002171 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 471223002172 dimer interface [polypeptide binding]; other site 471223002173 conserved gate region; other site 471223002174 putative PBP binding loops; other site 471223002175 ABC-ATPase subunit interface; other site 471223002176 oligopeptide ABC transporter permease OppC; Provisional; Region: PRK15406 471223002177 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 471223002178 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 471223002179 dimer interface [polypeptide binding]; other site 471223002180 conserved gate region; other site 471223002181 putative PBP binding loops; other site 471223002182 ABC-ATPase subunit interface; other site 471223002183 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 471223002184 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 471223002185 Walker A/P-loop; other site 471223002186 ATP binding site [chemical binding]; other site 471223002187 Q-loop/lid; other site 471223002188 ABC transporter signature motif; other site 471223002189 Walker B; other site 471223002190 D-loop; other site 471223002191 H-loop/switch region; other site 471223002192 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 471223002193 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 471223002194 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 471223002195 Walker A/P-loop; other site 471223002196 ATP binding site [chemical binding]; other site 471223002197 Q-loop/lid; other site 471223002198 ABC transporter signature motif; other site 471223002199 Walker B; other site 471223002200 D-loop; other site 471223002201 H-loop/switch region; other site 471223002202 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 471223002203 Transposase, Mutator family; Region: Transposase_mut; pfam00872 471223002204 MULE transposase domain; Region: MULE; pfam10551 471223002205 Arsenate Reductase (ArsC) family, Spx subfamily; Spx is a unique RNA polymerase (RNAP)-binding protein present in bacilli and some mollicutes. It inhibits transcription by binding to the C-terminal domain of the alpha subunit of RNAP, disrupting complex...; Region: ArsC_Spx; cd03032 471223002206 ArsC family; Region: ArsC; pfam03960 471223002207 putative catalytic residues [active] 471223002208 thiol/disulfide switch; other site 471223002209 Integral membrane protein TerC family; Region: TerC; cl10468 471223002210 Negative regulator of genetic competence (MecA); Region: MecA; cl02022 471223002211 cardiolipin synthetase; Reviewed; Region: cls; PRK01642 471223002212 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 471223002213 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 471223002214 putative active site [active] 471223002215 catalytic site [active] 471223002216 catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112 471223002217 putative active site [active] 471223002218 catalytic site [active] 471223002219 Competence protein CoiA-like family; Region: CoiA; cl11541 471223002220 oligoendopeptidase F; Region: pepF; TIGR00181 471223002221 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_3; cd09608 471223002222 active site 471223002223 Zn binding site [ion binding]; other site 471223002224 DsbA family, FrnE-like subfamily; composed of uncharacterized proteins containing a CXXC motif with similarity to DsbA and FrnE. FrnE is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the...; Region: DsbA_FrnE_like; cd03025 471223002225 Thioredoxin; Region: Thioredoxin_5; pfam13743 471223002226 catalytic residues [active] 471223002227 Truncated hemoglobins (trHbs) are a family of oxygen-binding heme proteins found in cyanobacteria, eubacteria, unicellular eukaryotes, and plants. The truncated hemoglobins have a characteristic two-over-two alpha helical folding pattern that is distinct...; Region: Trunc_globin; cd00454 471223002228 apolar tunnel; other site 471223002229 heme binding site [chemical binding]; other site 471223002230 dimerization interface [polypeptide binding]; other site 471223002231 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic 'goose-type' lysozymes (GEWL). LTs catalyze...; Region: LT_GEWL; cd00254 471223002232 N-acetyl-D-glucosamine binding site [chemical binding]; other site 471223002233 catalytic residue [active] 471223002234 Uncharacterized subgroup 1 of the CYTH-like superfamily; Region: CYTH-like_Pase_1; cd07762 471223002235 putative active site [active] 471223002236 putative metal binding residues [ion binding]; other site 471223002237 signature motif; other site 471223002238 putative triphosphate binding site [ion binding]; other site 471223002239 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 471223002240 synthetase active site [active] 471223002241 NTP binding site [chemical binding]; other site 471223002242 metal binding site [ion binding]; metal-binding site 471223002243 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; cl01255 471223002244 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 471223002245 PseudoU_synth_RsuA/RluD: Pseudouridine synthase, RsuA/RluD family. This group is comprised of eukaryotic, bacterial and archeal proteins similar to eight site specific Escherichia coli pseudouridine synthases: RsuA, RluA, RluB, RluC, RluD, RluE, RluF and...; Region: PseudoU_synth_RluCD_like; cd02869 471223002246 active site 471223002247 bis(5'-nucleosyl)-tetraphosphatase PrpE; Provisional; Region: PRK13625 471223002248 Bacillus subtilis PrpE and related proteins, metallophosphatase domain; Region: MPP_PrpE; cd07423 471223002249 active site 471223002250 metal binding site [ion binding]; metal-binding site 471223002251 Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511 471223002252 Enoyl-[acyl-carrier-protein]; Region: FabI; COG0623 471223002253 Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372 471223002254 NAD binding site [chemical binding]; other site 471223002255 homotetramer interface [polypeptide binding]; other site 471223002256 homodimer interface [polypeptide binding]; other site 471223002257 substrate binding site [chemical binding]; other site 471223002258 active site 471223002259 Spore coat protein CotO; Region: Spore_coat_CotO; pfam14153 471223002260 Protein of unknown function (DUF1360); Region: DUF1360; pfam07098 471223002261 Bacteriophage holin; Region: Phage_holin_1; cl02344 471223002262 Protein of unknown function (DUF1657); Region: DUF1657; pfam07870 471223002263 Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ); Region: Spore_YhcN_YlaJ; pfam09580 471223002264 SpoVA protein; Region: SpoVA; cl04298 471223002265 stage V sporulation protein AD; Provisional; Region: PRK12404 471223002266 Stage V sporulation protein AD (SpoVAD); Region: SpoVAD; pfam07451 471223002267 SpoVA protein; Region: SpoVA; cl04298 471223002268 Protein of unknown function (DUF1657); Region: DUF1657; pfam07870 471223002269 Protein of unknown function (DUF421); Region: DUF421; cl00990 471223002270 Protein of unknown function (DUF1657); Region: DUF1657; pfam07870 471223002271 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 471223002272 catalytic residues [active] 471223002273 Stage VI sporulation protein F; Region: SpoVIF; pfam14069 471223002274 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 471223002275 Coenzyme A binding pocket [chemical binding]; other site 471223002276 hypothetical protein; Provisional; Region: PRK13679 471223002277 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 471223002278 Putative esterase; Region: Esterase; pfam00756 471223002279 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 471223002280 cystathionine gamma-synthase; Reviewed; Region: PRK08247 471223002281 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 471223002282 homodimer interface [polypeptide binding]; other site 471223002283 substrate-cofactor binding pocket; other site 471223002284 pyridoxal 5'-phosphate binding site [chemical binding]; other site 471223002285 catalytic residue [active] 471223002286 cystathionine beta-lyase; Provisional; Region: PRK08064 471223002287 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 471223002288 homodimer interface [polypeptide binding]; other site 471223002289 substrate-cofactor binding pocket; other site 471223002290 pyridoxal 5'-phosphate binding site [chemical binding]; other site 471223002291 catalytic residue [active] 471223002292 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 471223002293 Transposase; Region: DDE_Tnp_ISL3; pfam01610 471223002294 Predicted membrane protein [Function unknown]; Region: COG3428 471223002295 Bacterial PH domain; Region: DUF304; cl01348 471223002296 Bacterial PH domain; Region: DUF304; cl01348 471223002297 Bacterial PH domain; Region: DUF304; cl01348 471223002298 Bacterial PH domain; Region: DUF304; cl01348 471223002299 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 471223002300 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 471223002301 NAD(P) binding site [chemical binding]; other site 471223002302 catalytic residues [active] 471223002303 OsmC-like protein; Region: OsmC; cl00767 471223002304 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13905 471223002305 FAD binding domain; Region: FAD_binding_4; pfam01565 471223002306 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 471223002307 Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334 471223002308 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 471223002309 NAD(P) binding domain of glutamate dehydrogenase, subgroup 1; Region: NAD_bind_1_Glu_DH; cd01076 471223002310 NAD(P) binding site [chemical binding]; other site 471223002311 Transposase, Mutator family; Region: Transposase_mut; pfam00872 471223002312 MULE transposase domain; Region: MULE; pfam10551 471223002313 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 471223002314 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; cl01255 471223002315 Diacylglycerol kinase accessory domain; Region: DAGK_acc; cl02440 471223002316 DDE superfamily endonuclease; Region: DDE_5; cl02413 471223002317 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 471223002318 Archaeal putative transposase ISC1217; Region: DDE_Tnp_2; pfam04693 471223002319 CrcB-like protein; Region: CRCB; cl09114 471223002320 CrcB-like protein; Region: CRCB; cl09114 471223002321 Uncharacterized conserved protein [Function unknown]; Region: COG2966 471223002322 Protein of unknown function (DUF1212); Region: DUF1212; cl01118 471223002323 Protein of unknown function (DUF1212); Region: DUF1212; cl01118 471223002324 M20 Peptidase Aminoacylase 1 amhX_like subfamily; Region: M20_Acy1_amhX_like; cd08018 471223002325 amidohydrolase; Region: amidohydrolases; TIGR01891 471223002326 metal binding site [ion binding]; metal-binding site 471223002327 putative dimer interface [polypeptide binding]; other site 471223002328 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 471223002329 N-acylamino acid racemase (NAAAR), an octameric enzyme that catalyzes the racemization of N-acylamino acids. NAAARs act on a broad range of N-acylamino acids rather than amino acids. Enantiopure amino acids are of industrial interest as chiral building...; Region: NAAAR; cd03317 471223002330 o-succinylbenzoate synthase; Region: menC_lowGC/arch; TIGR01928 471223002331 active site 471223002332 octamer interface [polypeptide binding]; other site 471223002333 Sodium:solute symporter family; Region: SSF; cl00456 471223002334 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 471223002335 Protein of unknown function, DUF485; Region: DUF485; cl01231 471223002336 amino acid transporter; Region: 2A0306; TIGR00909 471223002337 Spore germination protein; Region: Spore_permease; cl15802 471223002338 Spore germination protein; Region: Spore_permease; cl15802 471223002339 Spore germination protein; Region: Spore_permease; cl15802 471223002340 putative RNA polymerase sigma factor SigI; Reviewed; Region: PRK08311 471223002341 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 471223002342 Anti-sigma factor N-terminus; Region: RsgI_N; pfam12791 471223002343 Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269 471223002344 Protein of unknown function (DUF3905); Region: DUF3905; pfam13045 471223002345 B12 binding domain_like associated with radical SAM domain. This domain shows similarity with B12 (adenosylcobamide) binding domains found in several enzymes, such as glutamate mutase, methionine synthase and methylmalonyl-CoA mutase, but it lacks the...; Region: radical_SAM_B12_BD; cd02068 471223002346 Elongator protein 3, MiaB family, Radical SAM; Region: Elp3; smart00729 471223002347 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 471223002348 FeS/SAM binding site; other site 471223002349 Protein of unknown function (DUF4080); Region: DUF4080; pfam13311 471223002350 PAS domain S-box; Region: sensory_box; TIGR00229 471223002351 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 471223002352 PAS domain S-box; Region: sensory_box; TIGR00229 471223002353 PAS domain S-box; Region: sensory_box; TIGR00229 471223002354 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 471223002355 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 471223002356 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 471223002357 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 471223002358 dimer interface [polypeptide binding]; other site 471223002359 phosphorylation site [posttranslational modification] 471223002360 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 471223002361 ATP binding site [chemical binding]; other site 471223002362 Mg2+ binding site [ion binding]; other site 471223002363 G-X-G motif; other site 471223002364 methylated-DNA--protein-cysteine methyltransferase; Provisional; Region: PRK00901 471223002365 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870 471223002366 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 471223002367 DNA binding site [nucleotide binding] 471223002368 active site 471223002369 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 471223002370 TM-ABC transporter signature motif; other site 471223002371 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 471223002372 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 471223002373 Walker A/P-loop; other site 471223002374 ATP binding site [chemical binding]; other site 471223002375 Q-loop/lid; other site 471223002376 ABC transporter signature motif; other site 471223002377 Walker B; other site 471223002378 D-loop; other site 471223002379 H-loop/switch region; other site 471223002380 This family represents domain II of the carbohydrate uptake proteins that transport only monosaccharides (Monos). The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and hexoses; Region: ABC_Carb_Monos_II; cd03215 471223002381 Methylthioribose-binding protein-like of ABC-type transport systems that belong to a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_methylthioribose_binding_like; cd06305 471223002382 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 471223002383 putative ligand binding site [chemical binding]; other site 471223002384 methylthioribose-1-phosphate isomerase; Reviewed; Region: mtnA; PRK05720 471223002385 Predicted translation initiation factor 2B subunit, eIF-2B alpha/beta/delta family [Translation, ribosomal structure and biogenesis]; Region: COG0182; cl00348 471223002386 Predicted aminoglycoside phosphotransferase [General function prediction only]; Region: COG3173 471223002387 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 471223002388 Predicted amidohydrolase [General function prediction only]; Region: COG0388 471223002389 Uncharacterized subgroup of the nitrilase superfamily (putative class 13 nitrilases); Region: nitrilase_5; cd07583 471223002390 putative active site [active] 471223002391 catalytic triad [active] 471223002392 putative dimer interface [polypeptide binding]; other site 471223002393 transaminase; Reviewed; Region: PRK08068 471223002394 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 471223002395 pyridoxal 5'-phosphate binding site [chemical binding]; other site 471223002396 homodimer interface [polypeptide binding]; other site 471223002397 catalytic residue [active] 471223002398 2,3-diketo-5-methylthiopentyl-1-phosphate enolase; Reviewed; Region: mtnW; PRK09549 471223002399 2,3-diketo-5-methylthiopentyl-1-phosphate enolase; Region: RLP_DK-MTP-1-P-enolase; cd08209 471223002400 dimer interface [polypeptide binding]; other site 471223002401 active site 471223002402 catalytic residue [active] 471223002403 metal binding site [ion binding]; metal-binding site 471223002404 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 471223002405 haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702 471223002406 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cl00214 471223002407 intersubunit interface [polypeptide binding]; other site 471223002408 active site 471223002409 Zn2+ binding site [ion binding]; other site 471223002410 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1791 471223002411 Cupin domain; Region: Cupin_2; cl09118 471223002412 Predicted divalent heavy-metal cations transporter [Inorganic ion transport and metabolism]; Region: COG0428; cl00437 471223002413 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 471223002414 Helix-turn-helix domains; Region: HTH; cl00088 471223002415 Helix-turn-helix domains; Region: HTH; cl00088 471223002416 Propanediol utilisation protein PduL; Region: PduL; pfam06130 471223002417 Propanediol utilisation protein PduL; Region: PduL; pfam06130 471223002418 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506 471223002419 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 471223002420 structural tetrad; other site 471223002421 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 471223002422 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 471223002423 Probable transposase; Region: OrfB_IS605; pfam01385 471223002424 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 471223002425 Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282 471223002426 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_1; cd09606 471223002427 oligoendopeptidase, M3 family; Region: M3_not_pepF; TIGR02289 471223002428 active site 471223002429 Zn binding site [ion binding]; other site 471223002430 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 471223002431 active site 471223002432 NTP binding site [chemical binding]; other site 471223002433 metal binding triad [ion binding]; metal-binding site 471223002434 antibiotic binding site [chemical binding]; other site 471223002435 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 471223002436 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 471223002437 Coenzyme A binding pocket [chemical binding]; other site 471223002438 Transposase; Region: DEDD_Tnp_IS110; pfam01548 471223002439 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 471223002440 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 471223002441 Helix-turn-helix domains; Region: HTH; cl00088 471223002442 Uncharacterized protein family (UPF0236); Region: UPF0236; pfam06782 471223002443 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; cl14891 471223002444 Integrase core domain; Region: rve; cl01316 471223002445 Transposase domain (DUF772); Region: DUF772; cl15789 471223002446 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 471223002447 Transposase domain (DUF772); Region: DUF772; cl15789 471223002448 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 471223002449 Transposase domain (DUF772); Region: DUF772; cl15789 471223002450 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 471223002451 Alcohol dehydrogenases of the MDR family; Region: Zn_ADH6; cd08260 471223002452 putative NAD(P) binding site [chemical binding]; other site 471223002453 catalytic Zn binding site [ion binding]; other site 471223002454 structural Zn binding site [ion binding]; other site 471223002455 ALDH subfamily: ALDH families 1and 2, including 10-formyltetrahydrofolate dehydrogenase, NAD+-dependent retinal dehydrogenase 1 and related proteins; Region: ALDH_F1-2_Ald2-like; cd07091 471223002456 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 471223002457 NAD(P) binding site [chemical binding]; other site 471223002458 catalytic residues [active] 471223002459 Modulator of heat shock repressor CtsR, McsA [Signal transduction mechanisms]; Region: COG3880 471223002460 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 471223002461 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 471223002462 Walker A motif; other site 471223002463 ATP binding site [chemical binding]; other site 471223002464 Walker B motif; other site 471223002465 arginine finger; other site 471223002466 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 471223002467 Walker A motif; other site 471223002468 ATP binding site [chemical binding]; other site 471223002469 Walker B motif; other site 471223002470 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; cl11083 471223002471 FixH; Region: FixH; cl01254 471223002472 FixH; Region: FixH; cl01254 471223002473 Uncharacterized membrane protein [Function unknown]; Region: COG3949 471223002474 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 471223002475 Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; cl05194 471223002476 Spore germination protein; Region: Spore_permease; cl15802 471223002477 ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995 471223002478 Ligand Binding Site [chemical binding]; other site 471223002479 Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1), 6-pyrovoyl...; Region: TFold; cl00263 471223002480 active site 471223002481 7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE; Region: Bsubt_queE; TIGR03365 471223002482 Protein of unknown function (DUF3603); Region: DUF3603; pfam12227 471223002483 Uncharacterized protein conserved in bacteria (DUF2187); Region: DUF2187; cl11556 471223002484 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118 471223002485 putative peptidoglycan binding site; other site 471223002486 Cell Wall Hydrolase; Region: Hydrolase_2; pfam07486 471223002487 YueH-like protein; Region: YueH; pfam14166 471223002488 Nitroreductase-like family 1. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_1; cd02137 471223002489 dimer interface [polypeptide binding]; other site 471223002490 FMN binding site [chemical binding]; other site 471223002491 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 471223002492 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 471223002493 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 471223002494 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 471223002495 active site 471223002496 motif I; other site 471223002497 motif II; other site 471223002498 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 471223002499 transcriptional antiterminator BglG; Provisional; Region: PRK09772 471223002500 CAT RNA binding domain; Region: CAT_RBD; cl03904 471223002501 PRD domain; Region: PRD; cl15445 471223002502 PRD domain; Region: PRD; cl15445 471223002503 Transposase; Region: DEDD_Tnp_IS110; pfam01548 471223002504 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 471223002505 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; cl00557 471223002506 PTS system, glucose-specific IIBC component; Region: PTS-II-BC-glcB; TIGR02002 471223002507 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 471223002508 active site turn [active] 471223002509 phosphorylation site [posttranslational modification] 471223002510 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210 471223002511 HPr interaction site; other site 471223002512 glycerol kinase (GK) interaction site [polypeptide binding]; other site 471223002513 active site 471223002514 phosphorylation site [posttranslational modification] 471223002515 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 471223002516 dimerization domain swap beta strand [polypeptide binding]; other site 471223002517 regulatory protein interface [polypeptide binding]; other site 471223002518 active site 471223002519 regulatory phosphorylation site [posttranslational modification]; other site 471223002520 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 471223002521 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 471223002522 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; cl01586 471223002523 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl09155 471223002524 Protein of unknown function (DUF1256); Region: DUF1256; cl06087 471223002525 Cache domain; Region: Cache_1; pfam02743 471223002526 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 471223002527 dimerization interface [polypeptide binding]; other site 471223002528 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 471223002529 dimer interface [polypeptide binding]; other site 471223002530 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 471223002531 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 471223002532 dimer interface [polypeptide binding]; other site 471223002533 putative CheW interface [polypeptide binding]; other site 471223002534 2-oxoglutarate dehydrogenase E1 component; Reviewed; Region: sucA; PRK09404 471223002535 Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016 471223002536 TPP-binding site [chemical binding]; other site 471223002537 Pyrimidine (PYR) binding domain of thiamine pyrophosphate (TPP)-dependent enzymes; Region: TPP_enzyme_PYR; cl11410 471223002538 dihydrolipoamide succinyltransferase; Validated; Region: PRK05704 471223002539 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 471223002540 E3 interaction surface; other site 471223002541 lipoyl attachment site [posttranslational modification]; other site 471223002542 e3 binding domain; Region: E3_binding; pfam02817 471223002543 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; cl02008 471223002544 Cupin domain; Region: Cupin_2; cl09118 471223002545 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 471223002546 putative beta-ketoacyl acyl carrier protein [ACP] reductase (BKR)-like, SDR; Region: BKR_like_SDR_like; cd05344 471223002547 putative NAD(P) binding site [chemical binding]; other site 471223002548 putative active site [active] 471223002549 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 471223002550 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 471223002551 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 471223002552 Acyl-CoA dehydrogenases similar to fadE2; Region: ACAD_FadE2; cd01155 471223002553 FAD binding site [chemical binding]; other site 471223002554 substrate binding site [chemical binding]; other site 471223002555 catalytic base [active] 471223002556 gluconate 5-dehydrogenase; Provisional; Region: PRK08213 471223002557 gluconate 5-dehydrogenase (Ga5DH)-like, classical (c) SDRs; Region: Ga5DH-like_SDR_c; cd05347 471223002558 NADP binding site [chemical binding]; other site 471223002559 homodimer interface [polypeptide binding]; other site 471223002560 active site 471223002561 Predicted aminoglycoside phosphotransferase [General function prediction only]; Region: COG3173 471223002562 Acyl-CoA dehydrogenase (ACAD) 10 and 11, N-terminal domain, and similar proteins. This subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: ACAD10_11_like; cd05154 471223002563 putative active site [active] 471223002564 putative substrate binding site [chemical binding]; other site 471223002565 ATP binding site [chemical binding]; other site 471223002566 2-phosphosulpholactate phosphatase; Region: 2-ph_phosp; cl00895 471223002567 putative NAD(P)H quinone oxidoreductase, PIG3 family; Region: quinone_pig3; TIGR02824 471223002568 Quinone oxidoreductase (QOR); Region: QOR2; cd05286 471223002569 NADP binding site [chemical binding]; other site 471223002570 dimer interface [polypeptide binding]; other site 471223002571 aminotransferase A; Validated; Region: PRK07683 471223002572 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 471223002573 pyridoxal 5'-phosphate binding site [chemical binding]; other site 471223002574 homodimer interface [polypeptide binding]; other site 471223002575 catalytic residue [active] 471223002576 IDEAL domain; Region: IDEAL; cl07452 471223002577 magnesium Mg(2+) and cobalt Co(2+) transport protein (corA); Region: corA; TIGR00383 471223002578 magnesium/nickel/cobalt transporter CorA; Provisional; Region: PRK11085; cl00459 471223002579 Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695 471223002580 BacA is a bacterial lysin from Enterococcus faecalis that degrades bacterial cell walls by catalyzing the hydrolysis of 1,4-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues. BacA is homologous to the YbfG and YkuG lysins of...; Region: GH25_BacA-like; cd06418 471223002581 active site 471223002582 CheW, a small regulator protein, unique to the chemotaxis signalling in prokaryotes and archea. CheW interacts with the histidine kinase CheA, most likely with the related regulatory domain of CheA. CheW is proposed to form signalling arrays together...; Region: CheW; cd00732 471223002583 putative CheA interaction surface; other site 471223002584 Response regulator receiver domain; Region: Response_reg; pfam00072 471223002585 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 471223002586 active site 471223002587 phosphorylation site [posttranslational modification] 471223002588 intermolecular recognition site; other site 471223002589 dimerization interface [polypeptide binding]; other site 471223002590 YkyB-like protein; Region: YkyB; pfam14177 471223002591 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 471223002592 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 471223002593 putative active site [active] 471223002594 putative metal binding site [ion binding]; other site 471223002595 short chain dehydrogenase; Provisional; Region: PRK07677 471223002596 Trans-2-enoyl-CoA reductase (TER) and 2,4-dienoyl-CoA reductase (DECR), atypical (a) SDR; Region: TER_DECR_SDR_a; cd05369 471223002597 NAD(P) binding site [chemical binding]; other site 471223002598 substrate binding site [chemical binding]; other site 471223002599 homotetramer interface [polypeptide binding]; other site 471223002600 active site 471223002601 homodimer interface [polypeptide binding]; other site 471223002602 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 471223002603 EAL-domain associated signalling protein domain; Region: YkuI_C; pfam10388 471223002604 Antirepressor AbbA; Region: AbbA_antirepres; pfam14156 471223002605 FOG: CBS domain [General function prediction only]; Region: COG0517 471223002606 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_30; cd04643 471223002607 Tetrahydrodipicolinate succinyltransferase N-terminal; Region: DapH_N; pfam08503 471223002608 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-acetyltransferase; Region: DapD_Ac; TIGR03532 471223002609 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (also called THP succinyltransferase): THDP N-succinyltransferase catalyzes the conversion of tetrahydrodipicolinate and succinyl-CoA to N-succinyltetrahydrodipicolinate and CoA; Region: LbH_THP_succinylT; cd03350 471223002610 active site 471223002611 trimer interface [polypeptide binding]; other site 471223002612 substrate binding site [chemical binding]; other site 471223002613 CoA binding site [chemical binding]; other site 471223002614 M20 Peptidase Aminoacyclase-1 YkuR-like proteins, including YkuR and Ama/HipO/HyuC proteins; Region: M20_Acy1_YkuR_like; cd05670 471223002615 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 471223002616 metal binding site [ion binding]; metal-binding site 471223002617 putative dimer interface [polypeptide binding]; other site 471223002618 Uncharacterized protein family (UPF0180); Region: UPF0180; cl04214 471223002619 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 471223002620 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 471223002621 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 471223002622 Protein of unknown function (DUF1447); Region: DUF1447; cl11492 471223002623 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 471223002624 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 471223002625 active site 471223002626 motif I; other site 471223002627 motif II; other site 471223002628 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 471223002629 motif II; other site 471223002630 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 471223002631 active site 471223002632 catalytic residues [active] 471223002633 metal binding site [ion binding]; metal-binding site 471223002634 Putative cell-wall binding lipoprotein; Region: YkyA; pfam10368 471223002635 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_x; TIGR03181 471223002636 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 471223002637 TPP-binding site [chemical binding]; other site 471223002638 tetramer interface [polypeptide binding]; other site 471223002639 heterodimer interface [polypeptide binding]; other site 471223002640 phosphorylation loop region [posttranslational modification] 471223002641 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 471223002642 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 471223002643 alpha subunit interface [polypeptide binding]; other site 471223002644 TPP binding site [chemical binding]; other site 471223002645 heterodimer interface [polypeptide binding]; other site 471223002646 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 471223002647 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 471223002648 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 471223002649 E3 interaction surface; other site 471223002650 lipoyl attachment site [posttranslational modification]; other site 471223002651 e3 binding domain; Region: E3_binding; pfam02817 471223002652 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; cl02008 471223002653 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06416 471223002654 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 471223002655 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 471223002656 Domain of unknown function (DUF1885); Region: DUF1885; pfam08968 471223002657 Protein of unknown function (DUF3055); Region: DUF3055; pfam11256 471223002658 Domain of unknown function (DUF4182); Region: DUF4182; pfam13790 471223002659 Arginine/lysine/ornithine decarboxylases [Amino acid transport and metabolism]; Region: LdcC; COG1982 471223002660 Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615 471223002661 homodimer interface [polypeptide binding]; other site 471223002662 pyridoxal 5'-phosphate binding site [chemical binding]; other site 471223002663 catalytic residue [active] 471223002664 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 471223002665 putative enoyl-[acyl-carrier-protein] reductase II; Region: enACPred_II; TIGR03151 471223002666 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 471223002667 FMN binding site [chemical binding]; other site 471223002668 substrate binding site [chemical binding]; other site 471223002669 putative catalytic residue [active] 471223002670 Uncharacterized protein family (UPF0223); Region: UPF0223; cl11484 471223002671 Inositol-monophosphatase-like domains. This family of phosphatases is dependent on bivalent metal ions such as Mg++, and many members are inhibited by Li+ (which is thought to displace a bivalent ion in the active site). Substrates include fructose-1; Region: IMPase_like; cd01637 471223002672 active site 471223002673 Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217 471223002674 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 471223002675 G1 box; other site 471223002676 putative GEF interaction site [polypeptide binding]; other site 471223002677 GTP/Mg2+ binding site [chemical binding]; other site 471223002678 Switch I region; other site 471223002679 G2 box; other site 471223002680 G3 box; other site 471223002681 Switch II region; other site 471223002682 G4 box; other site 471223002683 G5 box; other site 471223002684 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 471223002685 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 471223002686 YlaH-like protein; Region: YlaH; pfam14036 471223002687 Uncharacterized protein conserved in bacteria (DUF2197); Region: DUF2197; cl11558 471223002688 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 471223002689 Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ); Region: Spore_YhcN_YlaJ; pfam09580 471223002690 Domain of unknown function (DUF4277); Region: DUF4277; pfam14104 471223002691 Transposase [DNA replication, recombination, and repair]; Region: COG5421 471223002692 Protein of unknown function (DUF1507); Region: DUF1507; cl11487 471223002693 Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511 471223002694 pyruvate carboxylase; Reviewed; Region: PRK12999 471223002695 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 471223002696 ATP-grasp domain; Region: ATP-grasp_4; cl03087 471223002697 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; cl08365 471223002698 Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937 471223002699 active site 471223002700 catalytic residues [active] 471223002701 metal binding site [ion binding]; metal-binding site 471223002702 homodimer binding site [polypeptide binding]; other site 471223002703 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 471223002704 carboxyltransferase (CT) interaction site; other site 471223002705 biotinylation site [posttranslational modification]; other site 471223002706 Uncharacterized protein required for cytochrome oxidase assembly [Posttranslational modification, protein turnover, chaperones]; Region: CtaA; COG1612 471223002707 Cytochrome oxidase assembly protein; Region: COX15-CtaA; cl15852 471223002708 UbiA prenyltransferase family; Region: UbiA; cl00337 471223002709 Heme/copper-type cytochrome/quinol oxidases, subunit 2 [Energy production and conversion]; Region: CyoA; COG1622 471223002710 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; cl11412 471223002711 Cytochrome c; Region: Cytochrom_C; cl11414 471223002712 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 471223002713 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 471223002714 D-pathway; other site 471223002715 Putative ubiquinol binding site [chemical binding]; other site 471223002716 Low-spin heme (heme b) binding site [chemical binding]; other site 471223002717 Putative water exit pathway; other site 471223002718 Binuclear center (heme o3/CuB) [ion binding]; other site 471223002719 K-pathway; other site 471223002720 Putative proton exit pathway; other site 471223002721 Ubiquinol oxidase subunit III subfamily. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously...; Region: Ubiquinol_oxidase_III; cd02863 471223002722 Subunit I/III interface [polypeptide binding]; other site 471223002723 Subunit III/IV interface [polypeptide binding]; other site 471223002724 Prokaryotic Cytochrome C oxidase subunit IV; Region: COX4_pro; cl01204 471223002725 Cytochrome c oxidase caa3 assembly factor (Caa3_CtaG); Region: Caa3_CtaG; cl09173 471223002726 Protein of unknown function (DUF420); Region: DUF420; cl00989 471223002727 Asp23 family; Region: Asp23; cl00574 471223002728 YugN-like family; Region: YugN; pfam08868 471223002729 Uncharacterized protein with SCP/PR1 domains [Function unknown]; Region: COG2340 471223002730 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 471223002731 Putative coat protein; Region: YlbD_coat; pfam14071 471223002732 YlbE-like protein; Region: YlbE; pfam14003 471223002733 Protein of unknown function (DUF964); Region: DUF964; cl01483 471223002734 Uncharacterized protein conserved in bacteria (DUF2129); Region: DUF2129; cl11453 471223002735 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl15754 471223002736 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 471223002737 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 471223002738 active site 471223002739 (T/H)XGH motif; other site 471223002740 sporulation integral membrane protein YlbJ; Region: spore_ylbJ; TIGR02871 471223002741 Nucleoside recognition; Region: Gate; cl00486 471223002742 Nucleoside recognition; Region: Gate; cl00486 471223002743 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 471223002744 Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396 471223002745 active site 471223002746 nucleophile elbow; other site 471223002747 Predicted secreted protein containing a PDZ domain [Signal transduction mechanisms]; Region: SdrC; COG3480 471223002748 PDZ domain of ATP-dependent LON serine proteases. Most PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated. In this bacterial subfamily of protease-associated PDZ...; Region: PDZ_LON_protease; cd00986 471223002749 protein binding site [polypeptide binding]; other site 471223002750 Subunit ChlI of Mg-chelatase; Region: ChlI; cl12214 471223002751 hypothetical protein; Provisional; Region: PRK13670 471223002752 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 471223002753 Uncharacterized ACR, COG1399; Region: DUF177; cl00616 471223002754 Ribosomal L32p protein family; Region: Ribosomal_L32p; cl09115 471223002755 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 471223002756 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 471223002757 substrate binding site [chemical binding]; other site 471223002758 oxyanion hole (OAH) forming residues; other site 471223002759 trimer interface [polypeptide binding]; other site 471223002760 putative spore coat protein regulator protein YlbO; Provisional; Region: PRK13923 471223002761 transcription factor, RsfA family; Region: DNA_bind_RsfA; TIGR02894 471223002762 2-dehydropantoate 2-reductase; Reviewed; Region: PRK06522 471223002763 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 471223002764 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 471223002765 Protein of unknown function (DUF3397); Region: DUF3397; pfam11877 471223002766 Uncharacterized protein conserved in bacteria (DUF2317); Region: DUF2317; pfam10079 471223002767 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4365 471223002768 Predicted S-adenosylmethionine-dependent methyltransferase involved in cell envelope biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG0275 471223002769 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 471223002770 Septum formation initiator; Region: DivIC; cl11433 471223002771 stage V sporulation protein D; Region: spoVD_pbp; TIGR02214 471223002772 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 471223002773 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 471223002774 PASTA domain of PBP2x-like proteins, first repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_1; cd06576 471223002775 PASTA domain of PBP2x-like proteins, second repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_2; cd06575 471223002776 stage V sporulation protein D; Region: spoVD_pbp; TIGR02214 471223002777 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 471223002778 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 471223002779 PASTA domain. This domain is found at the C-termini of several Penicillin-binding proteins (PBPs) and bacterial serine/threonine kinases. It is a small globular fold consisting of 3 beta-sheets and an alpha-helix. The name PASTA is derived from PBP and...; Region: PASTA; cd06573 471223002780 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 471223002781 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 471223002782 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 471223002783 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 471223002784 UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770 471223002785 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 471223002786 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 471223002787 Mg++ binding site [ion binding]; other site 471223002788 putative catalytic motif [active] 471223002789 putative substrate binding site [chemical binding]; other site 471223002790 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK02472 471223002791 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 471223002792 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 471223002793 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 471223002794 Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511 471223002795 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13905 471223002796 FAD binding domain; Region: FAD_binding_4; pfam01565 471223002797 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 471223002798 Cell division septal protein [Cell envelope biogenesis, outer membrane]; Region: FtsQ; COG1589 471223002799 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 471223002800 Cell division protein FtsQ; Region: FtsQ; pfam03799 471223002801 Transposase; Region: DEDD_Tnp_IS110; pfam01548 471223002802 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 471223002803 Growth-arrest specific micro-tubule binding; Region: GAS; pfam13851 471223002804 Bacterial protein of unknown function (DUF881); Region: DUF881; pfam05949 471223002805 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3879 471223002806 Bacterial protein of unknown function (DUF881); Region: DUF881; pfam05949 471223002807 Protein of unknown function (DUF1290); Region: DUF1290; cl01587 471223002808 cell division protein FtsA; Region: ftsA; TIGR01174 471223002809 Cell division protein FtsA; Region: FtsA; cl11496 471223002810 Cell division protein FtsA; Region: FtsA; cl11496 471223002811 cell division protein FtsZ; Validated; Region: PRK09330 471223002812 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 471223002813 nucleotide binding site [chemical binding]; other site 471223002814 SulA interaction site; other site 471223002815 Sporulation factor SpoIIGA; Region: Peptidase_U4; pfam03419 471223002816 sigma-E processing peptidase SpoIIGA; Region: spore_II_GA; TIGR02854 471223002817 sporulation sigma factor SigE; Reviewed; Region: PRK08301 471223002818 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 471223002819 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 471223002820 DNA binding residues [nucleotide binding] 471223002821 sporulation sigma factor SigG; Reviewed; Region: PRK08215 471223002822 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 471223002823 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 471223002824 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 471223002825 DNA binding residues [nucleotide binding] 471223002826 Photosynthetic reaction center (RC) complex, subunit H; RC is an integral membrane protein-pigment complex which catalyzes light-induced reduction of ubiquinone to ubiquinol, generating a transmembrane electrochemical gradient of protons used to produce...; Region: PRCH; cl09959 471223002827 Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496 471223002828 Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; cl00650 471223002829 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635 471223002830 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 471223002831 catalytic residue [active] 471223002832 Protein of unknown function (DUF552); Region: DUF552; cl00775 471223002833 YGGT family; Region: YGGT; cl00508 471223002834 Uncharacterized conserved protein, contains S4-like domain [Function unknown]; Region: COG2302 471223002835 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 471223002836 RNA binding surface [nucleotide binding]; other site 471223002837 DivIVA protein; Region: DivIVA; pfam05103 471223002838 DivIVA domain; Region: DivI1A_domain; TIGR03544 471223002839 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743 471223002840 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 471223002841 HIGH motif; other site 471223002842 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 471223002843 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 471223002844 active site 471223002845 KMSKS motif; other site 471223002846 Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960 471223002847 tRNA binding surface [nucleotide binding]; other site 471223002848 anticodon binding site; other site 471223002849 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 471223002850 Signal peptidase (SPase) II; Region: Peptidase_A8; cl00458 471223002851 pseudouridine synthase, RluA family; Region: rluA_subfam; TIGR00005 471223002852 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 471223002853 RNA binding surface [nucleotide binding]; other site 471223002854 PseudoU_synth_RsuA/RluD: Pseudouridine synthase, RsuA/RluD family. This group is comprised of eukaryotic, bacterial and archeal proteins similar to eight site specific Escherichia coli pseudouridine synthases: RsuA, RluA, RluB, RluC, RluD, RluE, RluF and...; Region: PseudoU_synth_RluCD_like; cd02869 471223002855 active site 471223002856 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 471223002857 active site 471223002858 pyrimidine utilization transport protein G; Region: RutG; TIGR03616 471223002859 uracil-xanthine permease; Region: ncs2; TIGR00801 471223002860 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 471223002861 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 471223002862 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 471223002863 dihydroorotase; Validated; Region: pyrC; PRK09357 471223002864 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 471223002865 Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317 471223002866 active site 471223002867 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 471223002868 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; cl03056 471223002869 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 471223002870 catalytic site [active] 471223002871 subunit interface [polypeptide binding]; other site 471223002872 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 471223002873 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 471223002874 ATP-grasp domain; Region: ATP-grasp_4; cl03087 471223002875 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 471223002876 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 471223002877 ATP-grasp domain; Region: ATP-grasp_4; cl03087 471223002878 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 471223002879 IMP binding site; other site 471223002880 dimer interface [polypeptide binding]; other site 471223002881 interdomain contacts; other site 471223002882 partial ornithine binding site; other site 471223002883 dihydroorotate dehydrogenase electron transfer subunit; Reviewed; Region: PRK00054 471223002884 FAD/NAD binding domain in the electron transfer subunit of dihydroorotate dehydrogenase. Dihydroorotate dehydrogenases (DHODs) catalyze the only redox reaction in pyrimidine de novo biosynthesis. They catalyze the oxidation of (S)-dihydroorotate to...; Region: DHOD_e_trans; cd06218 471223002885 FAD binding pocket [chemical binding]; other site 471223002886 FAD binding motif [chemical binding]; other site 471223002887 phosphate binding motif [ion binding]; other site 471223002888 beta-alpha-beta structure motif; other site 471223002889 NAD binding pocket [chemical binding]; other site 471223002890 Iron coordination center [ion binding]; other site 471223002891 dihydroorotate dehydrogenase (subfamily 1) family protein; Region: pyrD_sub1_fam; TIGR01037 471223002892 Dihydroorotate dehydrogenase (DHOD) class 1B FMN-binding domain. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine...; Region: DHOD_1B_like; cd04740 471223002893 heterodimer interface [polypeptide binding]; other site 471223002894 active site 471223002895 FMN binding site [chemical binding]; other site 471223002896 homodimer interface [polypeptide binding]; other site 471223002897 substrate binding site [chemical binding]; other site 471223002898 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase contains two...; Region: OMP_decarboxylase_like; cd04725 471223002899 active site 471223002900 dimer interface [polypeptide binding]; other site 471223002901 orotate phosphoribosyltransferase; Validated; Region: pyrE; PRK00455 471223002902 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 471223002903 active site 471223002904 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 471223002905 putative active site [active] 471223002906 Fibronectin-binding protein A N-terminus (FbpA); Region: FbpA; pfam05833 471223002907 Domain of unknown function (DUF814); Region: DUF814; pfam05670 471223002908 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 471223002909 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; cl02930 471223002910 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 471223002911 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 471223002912 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 471223002913 motif II; other site 471223002914 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 471223002915 Uncharacterized protein family (UPF0236); Region: UPF0236; pfam06782 471223002916 hypothetical protein; Provisional; Region: PRK11820 471223002917 YicC-like family, N-terminal region; Region: YicC_N; pfam03755 471223002918 Domain of unknown function (DUF1732); Region: DUF1732; pfam08340 471223002919 Domain of unknown function (DUF370); Region: DUF370; cl00898 471223002920 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 471223002921 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 471223002922 catalytic site [active] 471223002923 G-X2-G-X-G-K; other site 471223002924 RNA polymerase Rpb6; Region: RNA_pol_Rpb6; cl14651 471223002925 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 471223002926 Flavoprotein; Region: Flavoprotein; cl08021 471223002927 DNA / pantothenate metabolism flavoprotein; Region: DFP; cl04410 471223002928 primosome assembly protein PriA; Validated; Region: PRK05580 471223002929 primosome assembly protein PriA; Validated; Region: PRK05580 471223002930 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 471223002931 ATP binding site [chemical binding]; other site 471223002932 putative Mg++ binding site [ion binding]; other site 471223002933 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 471223002934 nucleotide binding region [chemical binding]; other site 471223002935 ATP-binding site [chemical binding]; other site 471223002936 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 471223002937 active site 471223002938 catalytic residues [active] 471223002939 metal binding site [ion binding]; metal-binding site 471223002940 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 471223002941 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 471223002942 putative active site [active] 471223002943 substrate binding site [chemical binding]; other site 471223002944 putative cosubstrate binding site; other site 471223002945 catalytic site [active] 471223002946 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 471223002947 substrate binding site [chemical binding]; other site 471223002948 16S rRNA methyltransferase B; Provisional; Region: PRK14902 471223002949 RNA binding domain of NusB (N protein-Utilization Substance B) and Sun (also known as RrmB or Fmu) proteins. This family includes two orthologous groups exemplified by the transcription termination factor NusB and the N-terminal domain of the...; Region: NusB_Sun; cl00223 471223002950 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 471223002951 S-adenosylmethionine binding site [chemical binding]; other site 471223002952 ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK14455 471223002953 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 471223002954 FeS/SAM binding site; other site 471223002955 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 471223002956 Protein phosphatase 2C; Region: PP2C; pfam00481 471223002957 active site 471223002958 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 471223002959 Catalytic domain of Protein Kinases; Region: PKc; cd00180 471223002960 active site 471223002961 ATP binding site [chemical binding]; other site 471223002962 substrate binding site [chemical binding]; other site 471223002963 activation loop (A-loop); other site 471223002964 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2815 471223002965 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 471223002966 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 471223002967 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 471223002968 S1_YloQ_GTPase: YloQ GTase family (also known as YjeQ and CpgA), S1-like RNA-binding domain. Proteins in the YloQ GTase family bind the ribosome and have GTPase activity. The precise role of this family is unknown. The protein structure is composed of...; Region: S1_YloQ_GTPase; cd04466 471223002969 GTPase RsgA; Reviewed; Region: PRK00098 471223002970 RNA binding site [nucleotide binding]; other site 471223002971 homodimer interface [polypeptide binding]; other site 471223002972 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 471223002973 GTPase/Zn-binding domain interface [polypeptide binding]; other site 471223002974 GTP/Mg2+ binding site [chemical binding]; other site 471223002975 G4 box; other site 471223002976 G5 box; other site 471223002977 G1 box; other site 471223002978 Switch I region; other site 471223002979 G2 box; other site 471223002980 G3 box; other site 471223002981 Switch II region; other site 471223002982 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 471223002983 ribulose-phosphate 3-epimerase; Region: rpe; TIGR01163 471223002984 substrate binding site [chemical binding]; other site 471223002985 hexamer interface [polypeptide binding]; other site 471223002986 metal binding site [ion binding]; metal-binding site 471223002987 Thiamine pyrophosphokinase; Region: TPK; cd07995 471223002988 thiamine pyrophosphokinase; Region: thi_PPkinase; TIGR01378 471223002989 active site 471223002990 dimerization interface [polypeptide binding]; other site 471223002991 thiamine binding site [chemical binding]; other site 471223002992 Stage V sporulation protein family; Region: SpoV; cl15455 471223002993 Ribosomal L28 family; Region: Ribosomal_L28; cl00367 471223002994 Asp23 family; Region: Asp23; cl00574 471223002995 DAK2 domain fusion protein YloV; Region: YloV; TIGR03599 471223002996 DAK2 domain; Region: Dak2; cl03685 471223002997 Uncharacterized protein, DegV family COG1307; Region: DegV; cl00577 471223002998 L-serine dehydratase, iron-sulfur-dependent, beta subunit; Region: sda_beta; TIGR00719 471223002999 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 471223003000 C-terminal ACT domain of the L-serine dehydratase (LSD), iron-sulfur-dependent, beta subunit; Region: ACT_LSD; cd04903 471223003001 putative L-serine binding site [chemical binding]; other site 471223003002 Serine dehydratase alpha chain; Region: SDH_alpha; cl12120 471223003003 L-serine deaminase [Amino acid transport and metabolism]; Region: SdaA; COG1760 471223003004 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 471223003005 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 471223003006 generic binding surface II; other site 471223003007 ssDNA binding site; other site 471223003008 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 471223003009 ATP binding site [chemical binding]; other site 471223003010 putative Mg++ binding site [ion binding]; other site 471223003011 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 471223003012 nucleotide binding region [chemical binding]; other site 471223003013 ATP-binding site [chemical binding]; other site 471223003014 fatty acid biosynthesis transcriptional regulator; Provisional; Region: PRK04424 471223003015 Helix-turn-helix domains; Region: HTH; cl00088 471223003016 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 471223003017 Phosphate acetyl/butaryl transferase; Region: PTA_PTB; cl00390 471223003018 Acyl transferase domain; Region: Acyl_transf_1; cl08282 471223003019 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 471223003020 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 471223003021 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 471223003022 NAD(P) binding site [chemical binding]; other site 471223003023 homotetramer interface [polypeptide binding]; other site 471223003024 homodimer interface [polypeptide binding]; other site 471223003025 active site 471223003026 Phosphopantetheine attachment site; Region: PP-binding; cl09936 471223003027 ribonuclease III; Reviewed; Region: rnc; PRK00102 471223003028 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 471223003029 dimerization interface [polypeptide binding]; other site 471223003030 active site 471223003031 metal binding site [ion binding]; metal-binding site 471223003032 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 471223003033 dsRNA binding site [nucleotide binding]; other site 471223003034 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 471223003035 Barmotin is a tight junction-associated protein expressed in rat epithelial cells which is thought to have an important regulatory role in tight junction barrier function. Barmotin belongs to the SMC protein family. SMC proteins are large; Region: ABC_SMC_barmotin; cd03278 471223003036 Walker A/P-loop; other site 471223003037 ATP binding site [chemical binding]; other site 471223003038 Q-loop/lid; other site 471223003039 SMC proteins Flexible Hinge Domain; Region: SMC_hinge; cl05797 471223003040 Barmotin is a tight junction-associated protein expressed in rat epithelial cells which is thought to have an important regulatory role in tight junction barrier function. Barmotin belongs to the SMC protein family. SMC proteins are large; Region: ABC_SMC_barmotin; cd03278 471223003041 ABC transporter signature motif; other site 471223003042 Walker B; other site 471223003043 D-loop; other site 471223003044 H-loop/switch region; other site 471223003045 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 471223003046 SRP54-type protein, helical bundle domain; Region: SRP54_N; cl03758 471223003047 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 471223003048 P loop; other site 471223003049 GTP binding site [chemical binding]; other site 471223003050 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 471223003051 Putative helix-turn-helix protein, YlxM / p13 like; Region: UPF0122; pfam04297 471223003052 signal recognition particle protein; Provisional; Region: PRK10867 471223003053 SRP54-type protein, helical bundle domain; Region: SRP54_N; cl03758 471223003054 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 471223003055 P loop; other site 471223003056 GTP binding site [chemical binding]; other site 471223003057 Signal peptide binding domain; Region: SRP_SPB; pfam02978 471223003058 Ribosomal protein S16; Region: Ribosomal_S16; cl00368 471223003059 Predicted RNA-binding protein (contains KH domain) [General function prediction only]; Region: COG1837 471223003060 K homology RNA-binding domain, type I. KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains that...; Region: KH-I; cl00098 471223003061 Protein of unknown function (DUF2869); Region: DUF2869; pfam11068 471223003062 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 471223003063 RimM N-terminal domain; Region: RimM; pfam01782 471223003064 tRNA (Guanine-1)-methyltransferase; Region: tRNA_m1G_MT; cl00407 471223003065 Ribosomal protein L19; Region: Ribosomal_L19; cl00406 471223003066 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 471223003067 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 471223003068 Catalytic site [active] 471223003069 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 471223003070 GTPase YlqF; Reviewed; Region: rbgA; PRK09563 471223003071 Circularly permuted YlqF GTPase; Region: YlqF; cd01856 471223003072 GTP/Mg2+ binding site [chemical binding]; other site 471223003073 G4 box; other site 471223003074 G5 box; other site 471223003075 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 471223003076 G1 box; other site 471223003077 G1 box; other site 471223003078 GTP/Mg2+ binding site [chemical binding]; other site 471223003079 Switch I region; other site 471223003080 G2 box; other site 471223003081 G2 box; other site 471223003082 G3 box; other site 471223003083 G3 box; other site 471223003084 Switch II region; other site 471223003085 Switch II region; other site 471223003086 G4 box; other site 471223003087 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 471223003088 RNA/DNA hybrid binding site [nucleotide binding]; other site 471223003089 active site 471223003090 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257; cl15822 471223003091 succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696 471223003092 ATP-grasp domain; Region: ATP-grasp_4; cl03087 471223003093 CoA-ligase; Region: Ligase_CoA; cl02894 471223003094 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 471223003095 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 471223003096 CoA-ligase; Region: Ligase_CoA; cl02894 471223003097 Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695 471223003098 DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481 471223003099 DNA topoisomerase I; Validated; Region: PRK05582 471223003100 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 471223003101 active site 471223003102 interdomain interaction site; other site 471223003103 putative metal-binding site [ion binding]; other site 471223003104 nucleotide binding site [chemical binding]; other site 471223003105 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 471223003106 domain I; other site 471223003107 DNA binding groove [nucleotide binding] 471223003108 phosphate binding site [ion binding]; other site 471223003109 domain II; other site 471223003110 domain III; other site 471223003111 nucleotide binding site [chemical binding]; other site 471223003112 catalytic site [active] 471223003113 domain IV; other site 471223003114 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 471223003115 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 471223003116 NAD(FAD)-utilizing enzyme possibly involved in translation [Translation, ribosomal structure and biogenesis]; Region: Gid; COG1206 471223003117 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 471223003118 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 471223003119 XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798 471223003120 Int/Topo IB signature motif; other site 471223003121 active site 471223003122 Protease HslV and the ATPase/chaperone HslU are part of an ATP-dependent proteolytic system that is the prokaryotic homolog of the proteasome. HslV is a dimer of hexamers (a dodecamer) that forms a central proteolytic chamber with active sites on the...; Region: protease_HslV; cd01913 471223003123 active site 471223003124 HslU subunit interaction site [polypeptide binding]; other site 471223003125 ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201 471223003126 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 471223003127 Walker A motif; other site 471223003128 ATP binding site [chemical binding]; other site 471223003129 Walker B motif; other site 471223003130 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 471223003131 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; cl11083 471223003132 transcriptional repressor CodY; Validated; Region: PRK04158 471223003133 CodY GAF-like domain; Region: CodY; pfam06018 471223003134 Helix-turn-helix domains; Region: HTH; cl00088 471223003135 flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK05680 471223003136 Flagella basal body rod protein; Region: Flg_bb_rod; cl15793 471223003137 flagellar basal body rod protein FlgC; Reviewed; Region: flgC; PRK05681 471223003138 Flagella basal body rod protein; Region: Flg_bb_rod; cl15793 471223003139 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; cl15855 471223003140 Flagellar hook-basal body complex protein FliE; Region: FliE; cl09139 471223003141 flagellar MS-ring protein; Reviewed; Region: fliF; PRK06007 471223003142 Secretory protein of YscJ/FliF family; Region: YscJ_FliF; cl01907 471223003143 Flagellar M-ring protein C-terminal; Region: YscJ_FliF_C; pfam08345 471223003144 flagellar motor switch protein G; Validated; Region: fliG; PRK05686 471223003145 MgtE intracellular N domain; Region: MgtE_N; cl15244 471223003146 FliG C-terminal domain; Region: FliG_C; pfam01706 471223003147 flagellar assembly protein H; Validated; Region: fliH; PRK06669 471223003148 Flagellar assembly protein FliH; Region: FliH; pfam02108 471223003149 flagellum-specific ATP synthase; Validated; Region: fliI; PRK07721 471223003150 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; cl15275 471223003151 Flagellum-specific ATPase/type III secretory pathway virulence-related protein. This group of ATPases are responsible for the export of flagellum and virulence-related proteins. The bacterial flagellar motor is similar to the F0F1-ATPase, in that they...; Region: ATPase_flagellum-secretory_path_III; cd01136 471223003152 Walker A motif/ATP binding site; other site 471223003153 Walker B motif; other site 471223003154 flagellar biosynthesis chaperone; Validated; Region: fliJ; cl09161 471223003155 flagellar export protein FliJ; Region: flagell_FliJ; TIGR02473 471223003156 MgtE intracellular N domain; Region: MgtE_N; cl15244 471223003157 Flagellar hook-length control protein FliK; Region: Flg_hook; cl15269 471223003158 flagellar basal body rod modification protein; Provisional; Region: flgD; PRK09618 471223003159 Flagellar hook capping protein - N-terminal region; Region: FlgD; pfam03963 471223003160 flagellar basal body rod protein FlgG; Provisional; Region: flgG; PRK12636 471223003161 Flagella basal body rod protein; Region: Flg_bb_rod; cl15793 471223003162 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; cl15855 471223003163 Flagellar protein (FlbD); Region: FlbD; cl00683 471223003164 flagellar basal body-associated protein FliL; Reviewed; Region: fliL; PRK07718 471223003165 Flagellar basal body-associated protein FliL; Region: FliL; cl00681 471223003166 flagellar motor switch protein FliM; Validated; Region: fliM; PRK06666 471223003167 Surface presentation of antigens (SPOA); Region: SpoA; cl00819 471223003168 flagellar motor switch protein; Validated; Region: PRK08119 471223003169 Chemotaxis phosphatase CheX; Region: CheX; cl15816 471223003170 Chemotaxis phosphatase CheX; Region: CheX; cl15816 471223003171 Surface presentation of antigens (SPOA); Region: SpoA; cl00819 471223003172 Response regulator receiver domain; Region: Response_reg; pfam00072 471223003173 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 471223003174 active site 471223003175 phosphorylation site [posttranslational modification] 471223003176 intermolecular recognition site; other site 471223003177 dimerization interface [polypeptide binding]; other site 471223003178 Flagellar biosynthesis protein, FliO; Region: FliO; cl01247 471223003179 FliP family; Region: FliP; cl00593 471223003180 Bacterial export proteins, family 3; Region: Bac_export_3; cl00867 471223003181 Bacterial export proteins, family 1; Region: Bac_export_1; cl00734 471223003182 flagellar biosynthesis protein FlhB; Reviewed; Region: flhB; PRK05702 471223003183 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257; cl15822 471223003184 flagellar biosynthesis protein FlhA; Validated; Region: flhA; cl07980 471223003185 FHIPEP family; Region: FHIPEP; pfam00771 471223003186 flagellar biosynthesis regulator FlhF; Validated; Region: flhF; PRK05703 471223003187 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 471223003188 Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455 471223003189 FleN is a member of the Fer4_NifH superfamily. It shares the common function as an ATPase, with the ATP-binding domain at the N-terminus. In Pseudomonas aeruginosa, FleN gene is involved in regulating the number of flagella and chemotactic motility by...; Region: FleN-like; cd02038 471223003190 P-loop; other site 471223003191 chemotaxis-specific methylesterase; Provisional; Region: PRK00742 471223003192 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 471223003193 active site 471223003194 phosphorylation site [posttranslational modification] 471223003195 intermolecular recognition site; other site 471223003196 dimerization interface [polypeptide binding]; other site 471223003197 CheB methylesterase; Region: CheB_methylest; pfam01339 471223003198 Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643 471223003199 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 471223003200 putative binding surface; other site 471223003201 active site 471223003202 P2 response regulator binding domain; Region: P2; pfam07194 471223003203 Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895 471223003204 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 471223003205 ATP binding site [chemical binding]; other site 471223003206 Mg2+ binding site [ion binding]; other site 471223003207 G-X-G motif; other site 471223003208 CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731 471223003209 CheW, a small regulator protein, unique to the chemotaxis signalling in prokaryotes and archea. CheW interacts with the histidine kinase CheA, most likely with the related regulatory domain of CheA. CheW is proposed to form signalling arrays together...; Region: CheW; cd00732 471223003210 putative CheA interaction surface; other site 471223003211 Chemotaxis protein CheC, inhibitor of MCP methylation [Cell motility and secretion / Signal transduction mechanisms]; Region: CheC; COG1776 471223003212 Chemotaxis phosphatase CheX; Region: CheX; cl15816 471223003213 CheD chemotactic sensory transduction; Region: CheD; cl00810 471223003214 RNA polymerase sigma factor SigD; Validated; Region: PRK07670 471223003215 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 471223003216 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 471223003217 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 471223003218 DNA binding residues [nucleotide binding] 471223003219 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 471223003220 rRNA interaction site [nucleotide binding]; other site 471223003221 S8 interaction site; other site 471223003222 putative laminin-1 binding site; other site 471223003223 elongation factor Ts; Provisional; Region: tsf; PRK09377 471223003224 Ubiquitin Associated domain. The UBA domain is a commonly occurring sequence motif in some members of the ubiquitination pathway, UV excision repair proteins, and certain protein kinases. Although its specific role is so far unknown, it has been...; Region: UBA; cl00153 471223003225 Elongation factor TS; Region: EF_TS; pfam00889 471223003226 Elongation factor TS; Region: EF_TS; pfam00889 471223003227 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 471223003228 putative nucleotide binding site [chemical binding]; other site 471223003229 uridine monophosphate binding site [chemical binding]; other site 471223003230 homohexameric interface [polypeptide binding]; other site 471223003231 ribosome recycling factor; Reviewed; Region: frr; PRK00083 471223003232 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are 'recycled' and ready for another round of...; Region: RRF; cd00520 471223003233 hinge region; other site 471223003234 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475 471223003235 Putative undecaprenyl diphosphate synthase; Region: Prenyltransf; pfam01255 471223003236 catalytic residue [active] 471223003237 putative FPP diphosphate binding site; other site 471223003238 putative FPP binding hydrophobic cleft; other site 471223003239 dimer interface [polypeptide binding]; other site 471223003240 putative IPP diphosphate binding site; other site 471223003241 Cytidylyltransferase family; Region: CTP_transf_1; cl00347 471223003242 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447 471223003243 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 471223003244 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 471223003245 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 471223003246 RIP metalloprotease RseP; Region: TIGR00054 471223003247 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 471223003248 active site 471223003249 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 471223003250 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 471223003251 protein binding site [polypeptide binding]; other site 471223003252 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 471223003253 putative substrate binding region [chemical binding]; other site 471223003254 prolyl-tRNA synthetase; Provisional; Region: PRK09194 471223003255 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent formation of...; Region: ProRS_core_prok; cd00779 471223003256 dimer interface [polypeptide binding]; other site 471223003257 motif 1; other site 471223003258 active site 471223003259 motif 2; other site 471223003260 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334 471223003261 putative deacylase active site [active] 471223003262 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it attaches...; Region: class_II_aaRS-like_core; cl00268 471223003263 active site 471223003264 motif 3; other site 471223003265 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 471223003266 anticodon binding site; other site 471223003267 DNA polymerase III PolC; Validated; Region: polC; PRK00448 471223003268 DNA polymerase III polC-type N-terminus; Region: DNA_pol3_alph_N; pfam11490 471223003269 polC_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold nucleic acid binding domain of Bacillus subtilis type C replicative DNA polymerase III alpha subunit (polC). Replication in B. subtilis and Staphylococcus aureus requires two...; Region: polC_OBF; cd04484 471223003270 generic binding surface II; other site 471223003271 generic binding surface I; other site 471223003272 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 471223003273 active site 471223003274 substrate binding site [chemical binding]; other site 471223003275 catalytic site [active] 471223003276 Bacterial DNA polymerase III alpha subunit; Region: DNA_pol3_alpha; pfam07733 471223003277 ribosome maturation protein RimP; Reviewed; Region: PRK00092 471223003278 The eukaryotic Sm and Sm-like (LSm) proteins associate with RNA to form the core domain of the ribonucleoprotein particles involved in a variety of RNA processing events including pre-mRNA splicing, telomere replication, and mRNA degradation. Members of...; Region: Sm_like; cl00259 471223003279 YxlS is a Bacillus subtilis gene of unknown function with two domains that each have an alpha/beta fold. The N-terminal domain is composed of two alpha-helices and a three-stranded beta-sheet, while the C-terminal domain is composed of one alpha-helix...; Region: YlxS_C; cd01734 471223003280 Sm1 motif; other site 471223003281 predicted subunit interaction site [polypeptide binding]; other site 471223003282 RNA binding pocket [nucleotide binding]; other site 471223003283 Sm2 motif; other site 471223003284 transcription elongation factor NusA; Provisional; Region: nusA; PRK12327 471223003285 NusA N-terminal domain; Region: NusA_N; pfam08529 471223003286 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 471223003287 RNA binding site [nucleotide binding]; other site 471223003288 homodimer interface [polypeptide binding]; other site 471223003289 K homology RNA-binding domain, type I. KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains that...; Region: KH-I; cl00098 471223003290 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 471223003291 G-X-X-G motif; other site 471223003292 Ylxr homologs; group of conserved hypothetical bacterial proteins of unknown function; structure revealed putative RNA binding cleft; proteins are encoded by an operon that includes other proteins involved in transcription and/or translation; Region: YlxR; cd00279 471223003293 putative RNA binding cleft [nucleotide binding]; other site 471223003294 Ribosomal protein L7Ae/L30e/S12e/Gadd45 family; Region: Ribosomal_L7Ae; cl00600 471223003295 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 471223003296 translation initiation factor IF-2; Region: IF-2; TIGR00487 471223003297 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 471223003298 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 471223003299 G1 box; other site 471223003300 putative GEF interaction site [polypeptide binding]; other site 471223003301 GTP/Mg2+ binding site [chemical binding]; other site 471223003302 Switch I region; other site 471223003303 G2 box; other site 471223003304 G3 box; other site 471223003305 Switch II region; other site 471223003306 G4 box; other site 471223003307 G5 box; other site 471223003308 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 471223003309 Translation-initiation factor 2; Region: IF-2; pfam11987 471223003310 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 471223003311 Protein of unknown function (DUF503); Region: DUF503; cl00669 471223003312 Ribosome-binding factor A; Region: RBFA; cl00542 471223003313 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK01550 471223003314 PseudoU_synth_EcTruB: Pseudouridine synthase, Escherichia coli TruB like. This group consists of bacterial pseudouridine synthases similar to E. coli TruB and Mycobacterium tuberculosis TruB. Pseudouridine synthases catalyze the isomerization of specific...; Region: PseudoU_synth_EcTruB; cd02573 471223003315 RNA binding site [nucleotide binding]; other site 471223003316 active site 471223003317 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 471223003318 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 471223003319 active site 471223003320 Riboflavin kinase; Region: Flavokinase; cl03312 471223003321 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 471223003322 16S/18S rRNA binding site [nucleotide binding]; other site 471223003323 S13e-L30e interaction site [polypeptide binding]; other site 471223003324 25S rRNA binding site [nucleotide binding]; other site 471223003325 polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824 471223003326 Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363 471223003327 RNase E interface [polypeptide binding]; other site 471223003328 trimer interface [polypeptide binding]; other site 471223003329 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 471223003330 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 471223003331 RNase E interface [polypeptide binding]; other site 471223003332 trimer interface [polypeptide binding]; other site 471223003333 active site 471223003334 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 471223003335 putative nucleic acid binding region [nucleotide binding]; other site 471223003336 G-X-X-G motif; other site 471223003337 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 471223003338 RNA binding site [nucleotide binding]; other site 471223003339 domain interface; other site 471223003340 probable sporulation protein, polysaccharide deacetylase family; Region: spore_ylxY; TIGR02873 471223003341 Putative catalytic NodB homology domain of uncharacterized protein YlxY from Bacillus subtilis and its bacterial homologs; Region: CE4_BsYlxY_like; cd10950 471223003342 NodB motif; other site 471223003343 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 471223003344 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 471223003345 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 471223003346 Photosynthetic reaction center (RC) complex, subunit H; RC is an integral membrane protein-pigment complex which catalyzes light-induced reduction of ubiquinone to ubiquinol, generating a transmembrane electrochemical gradient of protons used to produce...; Region: PRCH; cl09959 471223003347 dipicolinate synthase subunit A; Reviewed; Region: PRK08306 471223003348 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 471223003349 Flavoprotein; Region: Flavoprotein; cl08021 471223003350 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 471223003351 transposase, putative, N-terminal domain; Region: tspaseT_teng_N; TIGR01765 471223003352 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 471223003353 Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282 471223003354 aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874 471223003355 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 471223003356 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; cl15856 471223003357 aspartate kinase I; Reviewed; Region: PRK08210 471223003358 Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452 471223003359 nucleotide binding site [chemical binding]; other site 471223003360 substrate binding site [chemical binding]; other site 471223003361 ACT domains of the diaminopimelate-sensitive aspartokinase (AK) isoenzyme AKI; Region: ACT_AKi-DapG-BS_1; cd04914 471223003362 ACT domains of the diaminopimelate-sensitive aspartokinase (AK) isoenzyme AKI; Region: ACT_AKi-DapG-BS_2; cd04937 471223003363 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 471223003364 dihydrodipicolinate synthase; Region: dapA; TIGR00674 471223003365 dimer interface [polypeptide binding]; other site 471223003366 active site 471223003367 catalytic residue [active] 471223003368 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 471223003369 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 471223003370 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 471223003371 Clp protease; Region: CLP_protease; pfam00574 471223003372 Caseinolytic protease (ClpP) is an ATP-dependent protease; Region: Clp_protease_like; cl15763 471223003373 active site 471223003374 YlzJ-like protein; Region: YlzJ; pfam14035 471223003375 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 471223003376 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 471223003377 Ftsk gamma domain; Region: Ftsk_gamma; cl09645 471223003378 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 471223003379 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 471223003380 DNA-binding site [nucleotide binding]; DNA binding site 471223003381 UTRA domain; Region: UTRA; cl01230 471223003382 Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744 471223003383 Periplasmic binding domain of basic membrane lipoprotein, PnrA, in Treponema pallidum and its homologs from other bacteria and Archaea; Region: PBP1_BmpA_PnrA_like; cd06354 471223003384 ligand binding site [chemical binding]; other site 471223003385 ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845 471223003386 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 471223003387 Walker A/P-loop; other site 471223003388 ATP binding site [chemical binding]; other site 471223003389 Q-loop/lid; other site 471223003390 ABC transporter signature motif; other site 471223003391 Walker B; other site 471223003392 D-loop; other site 471223003393 H-loop/switch region; other site 471223003394 This family represents domain II of the carbohydrate uptake proteins that transport only monosaccharides (Monos). The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and hexoses; Region: ABC_Carb_Monos_II; cd03215 471223003395 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 471223003396 TM-ABC transporter signature motif; other site 471223003397 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 471223003398 TM-ABC transporter signature motif; other site 471223003399 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 471223003400 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 471223003401 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 471223003402 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 471223003403 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 471223003404 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 471223003405 classical (c) SDRs; Region: SDR_c; cd05233 471223003406 NAD(P) binding site [chemical binding]; other site 471223003407 active site 471223003408 Protein of unknown function (DUF3243); Region: DUF3243; pfam11588 471223003409 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 471223003410 Protein of unknown function (DUF3388); Region: DUF3388; pfam11868 471223003411 Predicted transcriptional regulator contains Xre-like HTH domain [Function unknown]; Region: COG1426 471223003412 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 471223003413 non-specific DNA binding site [nucleotide binding]; other site 471223003414 salt bridge; other site 471223003415 sequence-specific DNA binding site [nucleotide binding]; other site 471223003416 Domain of unknown function (DUF4115); Region: DUF4115; pfam13464 471223003417 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 471223003418 competence damage-inducible protein A; Provisional; Region: PRK00549 471223003419 Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885 471223003420 putative MPT binding site; other site 471223003421 Competence-damaged protein; Region: CinA; cl00666 471223003422 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 471223003423 Walker A motif; other site 471223003424 ATP binding site [chemical binding]; other site 471223003425 RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651 471223003426 Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078 471223003427 putative active site [active] 471223003428 putative NTP binding site [chemical binding]; other site 471223003429 putative nucleic acid binding site [nucleotide binding]; other site 471223003430 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 471223003431 active site 471223003432 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 471223003433 Walker B motif; other site 471223003434 phosphodiesterase; Provisional; Region: PRK12704 471223003435 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 471223003436 Cation efflux family; Region: Cation_efflux; cl00316 471223003437 Deinococcus radiodurans DR1281 and related proteins, metallophosphatase domain; Region: MPP_DR1281; cd07382 471223003438 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 471223003439 putative active site [active] 471223003440 metal binding site [ion binding]; metal-binding site 471223003441 homodimer binding site [polypeptide binding]; other site 471223003442 Stage V sporulation protein S (SpoVS); Region: SpoVS; cl01005 471223003443 renal dipeptidase (rDP), best studied in mammals and also called membrane or microsomal dipeptidase, is a membrane-bound glycoprotein hydrolyzing dipeptides and is involved in hydrolytic metabolism of penem and carbapenem beta-lactam antibiotics; Region: rDP_like; cd01301 471223003444 active site 471223003445 dimer interface [polypeptide binding]; other site 471223003446 2-oxoacid:acceptor oxidoreductase, alpha subunit; Region: OAFO_sf; TIGR03710 471223003447 Pyruvate ferredoxin/flavodoxin oxidoreductase; Region: POR; cl00546 471223003448 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 471223003449 dimer interface [polypeptide binding]; other site 471223003450 PYR/PP interface [polypeptide binding]; other site 471223003451 TPP binding site [chemical binding]; other site 471223003452 substrate binding site [chemical binding]; other site 471223003453 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 471223003454 2-oxoglutarate ferredoxin oxidoreductase subunit beta; Reviewed; Region: PRK11867 471223003455 Thiamine pyrophosphate (TPP family), 2-oxoglutarate ferredoxin oxidoreductase (OGFOR) subfamily, TPP-binding module; OGFOR catalyzes the oxidative decarboxylation of 2-oxo-acids, with ferredoxin acting as an electron acceptor. In the TCA cycle, OGFOR...; Region: TPP_OGFOR; cd03375 471223003456 TPP-binding site [chemical binding]; other site 471223003457 Pyruvate ferredoxin oxidoreductase beta subunit C terminal; Region: PFO_beta_C; pfam12367 471223003458 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14327 471223003459 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 471223003460 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 471223003461 FeS/SAM binding site; other site 471223003462 TRAM domain; Region: TRAM; cl01282 471223003463 Protein of unknown function (DUF964); Region: DUF964; cl01483 471223003464 Outer spore coat protein E (CotE); Region: CotE; pfam10628 471223003465 Acetone carboxylase, gamma subunit [Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcxC; COG4647 471223003466 Acetone carboxylase gamma subunit; Region: Acetone_carb_G; pfam08882 471223003467 DNA mismatch repair protein MutS; Provisional; Region: PRK05399 471223003468 MutS domain I; Region: MutS_I; pfam01624 471223003469 MutS domain II; Region: MutS_II; pfam05188 471223003470 MutS family domain IV; Region: MutS_IV; pfam05190 471223003471 MutS1 homolog in eukaryotes. The MutS protein initiates DNA mismatch repair by recognizing mispaired and unpaired bases embedded in duplex DNA and activating endo- and exonucleases to remove the mismatch. Members of the MutS family possess C-terminal...; Region: ABC_MutS1; cd03284 471223003472 Walker A/P-loop; other site 471223003473 ATP binding site [chemical binding]; other site 471223003474 Q-loop/lid; other site 471223003475 ABC transporter signature motif; other site 471223003476 Walker B; other site 471223003477 D-loop; other site 471223003478 H-loop/switch region; other site 471223003479 DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095 471223003480 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 471223003481 ATP binding site [chemical binding]; other site 471223003482 Mg2+ binding site [ion binding]; other site 471223003483 G-X-G motif; other site 471223003484 MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is...; Region: MutL_Trans; cd00782 471223003485 ATP binding site [chemical binding]; other site 471223003486 MutL C terminal dimerisation domain; Region: MutL_C; cl07336 471223003487 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 471223003488 Uncharacterized conserved protein [Function unknown]; Region: COG1284 471223003489 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 471223003490 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 471223003491 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; cl10498 471223003492 Amino acid permease; Region: AA_permease_2; pfam13520 471223003493 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118 471223003494 putative peptidoglycan binding site; other site 471223003495 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 471223003496 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118 471223003497 putative peptidoglycan binding site; other site 471223003498 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118 471223003499 putative peptidoglycan binding site; other site 471223003500 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 471223003501 NlpC/P60 family; Region: NLPC_P60; cl11438 471223003502 Nitrous oxidase accessory protein [Inorganic ion transport and metabolism]; Region: NosD; COG3420 471223003503 parallel beta-helix repeat (two copies); Region: para_beta_helix; TIGR03804 471223003504 parallel beta-helix repeat (two copies); Region: para_beta_helix; TIGR03804 471223003505 parallel beta-helix repeat (two copies); Region: para_beta_helix; TIGR03804 471223003506 NosL; Region: NosL; cl01769 471223003507 ABC-2 type transporter; Region: ABC2_membrane; cl11417 471223003508 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 471223003509 This family of ATP-binding proteins belongs to a multisubunit transporter involved in drug resistance (BcrA and DrrA), nodulation, lipid transport, and lantibiotic immunity. In bacteria and archaea, these transporters usually include an ATP-binding...; Region: ABC_DR_subfamily_A; cd03230 471223003510 Walker A/P-loop; other site 471223003511 ATP binding site [chemical binding]; other site 471223003512 Q-loop/lid; other site 471223003513 ABC transporter signature motif; other site 471223003514 Walker B; other site 471223003515 D-loop; other site 471223003516 H-loop/switch region; other site 471223003517 BCCT family transporter; Region: BCCT; cl00569 471223003518 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 471223003519 Major Facilitator Superfamily; Region: MFS_1; pfam07690 471223003520 putative substrate translocation pore; other site 471223003521 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 471223003522 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 471223003523 CHASE3 domain; Region: CHASE3; cl05000 471223003524 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 471223003525 dimerization interface [polypeptide binding]; other site 471223003526 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 471223003527 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 471223003528 dimer interface [polypeptide binding]; other site 471223003529 putative CheW interface [polypeptide binding]; other site 471223003530 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 471223003531 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 471223003532 Hfq, an abundant, ubiquitous RNA-binding protein, functions as a pleiotrophic regulator of RNA metabolism in prokaryotes, required for transcription of some transcripts and degradation of others. Hfq binds small RNA molecules called riboregulators that...; Region: Hfq; cd01716 471223003533 Sm1 motif; other site 471223003534 intra - hexamer interaction site; other site 471223003535 inter - hexamer interaction site [polypeptide binding]; other site 471223003536 nucleotide binding pocket [chemical binding]; other site 471223003537 Sm2 motif; other site 471223003538 stage V sporulation protein K; Region: spore_V_K; TIGR02881 471223003539 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 471223003540 Walker A motif; other site 471223003541 ATP binding site [chemical binding]; other site 471223003542 Walker B motif; other site 471223003543 arginine finger; other site 471223003544 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187 471223003545 AMP-binding enzyme; Region: AMP-binding; cl15778 471223003546 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 471223003547 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 471223003548 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 471223003549 active site 471223003550 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 471223003551 CoA-transferase family III; Region: CoA_transf_3; pfam02515 471223003552 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187 471223003553 AMP-binding enzyme; Region: AMP-binding; cl15778 471223003554 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 471223003555 3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK05808 471223003556 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 471223003557 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 471223003558 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 471223003559 acetyl-CoA acetyltransferases; Region: AcCoA-C-Actrans; TIGR01930 471223003560 dimer interface [polypeptide binding]; other site 471223003561 active site 471223003562 Predicted membrane protein [Function unknown]; Region: COG2860 471223003563 UPF0126 domain; Region: UPF0126; pfam03458 471223003564 UPF0126 domain; Region: UPF0126; pfam03458 471223003565 GTP-binding protein HflX; Region: GTP_HflX; TIGR03156 471223003566 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 471223003567 HflX GTPase family; Region: HflX; cd01878 471223003568 G1 box; other site 471223003569 GTP/Mg2+ binding site [chemical binding]; other site 471223003570 Switch I region; other site 471223003571 G2 box; other site 471223003572 G3 box; other site 471223003573 Switch II region; other site 471223003574 G4 box; other site 471223003575 G5 box; other site 471223003576 Cystathionine beta-lyase family protein involved in aluminum resistance [Inorganic ion transport and metabolism]; Region: COG4100 471223003577 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 471223003578 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 471223003579 catalytic residue [active] 471223003580 Helix-Turn-Helix DNA binding domain of GlnR-like transcription regulators; Region: HTH_GlnR-like; cd01105 471223003581 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 471223003582 DNA binding residues [nucleotide binding] 471223003583 putative dimer interface [polypeptide binding]; other site 471223003584 glutamine synthetase, type I; Region: GlnA; TIGR00653 471223003585 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 471223003586 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 471223003587 LexA repressor; Validated; Region: PRK00215 471223003588 Helix-turn-helix domains; Region: HTH; cl00088 471223003589 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 471223003590 Catalytic site [active] 471223003591 cell division suppressor protein YneA; Provisional; Region: PRK14125 471223003592 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cl00107 471223003593 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 471223003594 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 471223003595 catalytic residues [active] 471223003596 catalytic nucleophile [active] 471223003597 Bacterial protein of unknown function (DUF896); Region: DUF896; cl01722 471223003598 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 471223003599 Probable transposase; Region: OrfB_IS605; pfam01385 471223003600 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 471223003601 Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282 471223003602 Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021 471223003603 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 471223003604 TPP-binding site [chemical binding]; other site 471223003605 dimer interface [polypeptide binding]; other site 471223003606 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 471223003607 PYR/PP interface [polypeptide binding]; other site 471223003608 dimer interface [polypeptide binding]; other site 471223003609 TPP binding site [chemical binding]; other site 471223003610 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 471223003611 Protein of unknown function (DUF2522); Region: DUF2522; pfam10747 471223003612 Uncharacterized protein family (UPF0154); Region: UPF0154; cl01536 471223003613 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 471223003614 putative multidrug transporter membrane\ATP-binding components; Provisional; Region: PRK10789 471223003615 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 471223003616 Walker A/P-loop; other site 471223003617 ATP binding site [chemical binding]; other site 471223003618 Q-loop/lid; other site 471223003619 ABC transporter signature motif; other site 471223003620 Walker B; other site 471223003621 D-loop; other site 471223003622 H-loop/switch region; other site 471223003623 putative multidrug transporter membrane\ATP-binding components; Provisional; Region: PRK10790 471223003624 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 471223003625 Glucan exporter ATP-binding protein. In A. tumefaciens cyclic beta-1, 2-glucan must be transported into the periplasmic space to exert its action as a virluence factor. This subfamily belongs to the MRP-like family and is involved in drug, peptide, and...; Region: ABCC_Glucan_exporter_like; cd03254 471223003626 Walker A/P-loop; other site 471223003627 ATP binding site [chemical binding]; other site 471223003628 Q-loop/lid; other site 471223003629 ABC transporter signature motif; other site 471223003630 Walker B; other site 471223003631 D-loop; other site 471223003632 H-loop/switch region; other site 471223003633 Spo0E like sporulation regulatory protein; Region: SpoOE-like; pfam09388 471223003634 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 471223003635 Response regulator receiver domain; Region: Response_reg; pfam00072 471223003636 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 471223003637 active site 471223003638 phosphorylation site [posttranslational modification] 471223003639 intermolecular recognition site; other site 471223003640 dimerization interface [polypeptide binding]; other site 471223003641 Protein of unknown function (DUF1453); Region: DUF1453; cl02009 471223003642 Protein of unknown function (DUF2621); Region: DUF2621; pfam11084 471223003643 cell division suppressor protein YneA; Provisional; Region: PRK14125 471223003644 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118 471223003645 putative peptidoglycan binding site; other site 471223003646 Cell Wall Hydrolase; Region: Hydrolase_2; pfam07486 471223003647 Uncharacterized protein family (UPF0236); Region: UPF0236; pfam06782 471223003648 alpha-crystallin domain (ACD) found in alpha-crystallin-type small heat shock proteins, and a similar domain found in p23 (a cochaperone for Hsp90) and in other p23-like proteins; Region: alpha-crystallin-Hsps_p23-like; cl00175 471223003649 Small acid-soluble spore protein P family; Region: SspP; cl12105 471223003650 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 471223003651 transposase, putative, N-terminal domain; Region: tspaseT_teng_N; TIGR01765 471223003652 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 471223003653 Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282 471223003654 aconitate hydratase; Validated; Region: PRK09277 471223003655 Aconitase A catalytic domain; Region: AcnA_IRP; cd01586 471223003656 substrate binding site [chemical binding]; other site 471223003657 ligand binding site [chemical binding]; other site 471223003658 Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580 471223003659 substrate binding site [chemical binding]; other site 471223003660 small, acid-soluble spore protein L; Region: SASP_sspL; TIGR03093 471223003661 EamA-like transporter family; Region: EamA; cl01037 471223003662 hypothetical protein; Validated; Region: PRK07708 471223003663 RNAse HI family that includes Archaeal RNase HI; Region: RNase_HI_archaeal_like; cd09279 471223003664 RNA/DNA hybrid binding site [nucleotide binding]; other site 471223003665 active site 471223003666 Protein of unknown function (DUF2602); Region: DUF2602; pfam10782 471223003667 Protein of unknown function (DUF2564); Region: DUF2564; pfam10819 471223003668 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box protein; Region: CSP_CDS; cd04458 471223003669 DNA-binding site [nucleotide binding]; DNA binding site 471223003670 RNA-binding motif; other site 471223003671 Sporulation control protein [General function prediction only]; Region: Spo0M; COG4326 471223003672 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333 471223003673 amphipathic channel; other site 471223003674 Asn-Pro-Ala signature motifs; other site 471223003675 glycerol kinase; Provisional; Region: glpK; PRK00047 471223003676 Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786 471223003677 N- and C-terminal domain interface [polypeptide binding]; other site 471223003678 active site 471223003679 MgATP binding site [chemical binding]; other site 471223003680 catalytic site [active] 471223003681 metal binding site [ion binding]; metal-binding site 471223003682 glycerol binding site [chemical binding]; other site 471223003683 homotetramer interface [polypeptide binding]; other site 471223003684 homodimer interface [polypeptide binding]; other site 471223003685 FBP binding site [chemical binding]; other site 471223003686 protein IIAGlc interface [polypeptide binding]; other site 471223003687 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 471223003688 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 471223003689 Walker A/P-loop; other site 471223003690 ATP binding site [chemical binding]; other site 471223003691 Q-loop/lid; other site 471223003692 ABC transporter signature motif; other site 471223003693 Walker B; other site 471223003694 D-loop; other site 471223003695 H-loop/switch region; other site 471223003696 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 471223003697 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 471223003698 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 471223003699 Walker A/P-loop; other site 471223003700 ATP binding site [chemical binding]; other site 471223003701 Q-loop/lid; other site 471223003702 ABC transporter signature motif; other site 471223003703 Walker B; other site 471223003704 D-loop; other site 471223003705 H-loop/switch region; other site 471223003706 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 471223003707 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 471223003708 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 471223003709 dimer interface [polypeptide binding]; other site 471223003710 conserved gate region; other site 471223003711 putative PBP binding loops; other site 471223003712 ABC-ATPase subunit interface; other site 471223003713 nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790 471223003714 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 471223003715 dimer interface [polypeptide binding]; other site 471223003716 conserved gate region; other site 471223003717 putative PBP binding loops; other site 471223003718 ABC-ATPase subunit interface; other site 471223003719 The substrate binding component of an ABC-type lactococcal OppA-like transport system contains; Region: PBP2_Lactococcal_OppA_like; cd08510 471223003720 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 471223003721 peptide binding site [polypeptide binding]; other site 471223003722 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 471223003723 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 471223003724 active site 471223003725 metal binding site [ion binding]; metal-binding site 471223003726 membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082 471223003727 Putative ammonia monooxygenase; Region: AmoA; pfam05145 471223003728 membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082 471223003729 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 471223003730 CoenzymeA binding site [chemical binding]; other site 471223003731 subunit interaction site [polypeptide binding]; other site 471223003732 PHB binding site; other site 471223003733 Arginase family; Region: Arginase; cl00306 471223003734 Response regulator containing CheY-like receiver domain and AraC-type DNA-binding domain [Signal transduction mechanisms]; Region: COG4753 471223003735 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 471223003736 active site 471223003737 phosphorylation site [posttranslational modification] 471223003738 intermolecular recognition site; other site 471223003739 dimerization interface [polypeptide binding]; other site 471223003740 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 471223003741 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 471223003742 Probable transposase; Region: OrfB_IS605; pfam01385 471223003743 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 471223003744 Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282 471223003745 urocanate hydratase; Provisional; Region: PRK05414 471223003746 imidazolonepropionase; Validated; Region: PRK09356 471223003747 Imidazolonepropionase/imidazolone-5-propionate hydrolase (Imidazolone-5PH) catalyzes the third step in the histidine degradation pathway, the hydrolysis of (S)-3-(5-oxo-4,5-dihydro-3H-imidazol-4-yl)propanoate to N-formimidoyl-L-glutamate. In bacteria; Region: Imidazolone-5PH; cd01296 471223003748 active site 471223003749 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3314 471223003750 Nucleoside recognition; Region: Gate; cl00486 471223003751 Large-conductance mechanosensitive channel, MscL; Region: MscL; cl00860 471223003752 large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567 471223003753 Transposase DDE domain group 1; Region: DDE_Tnp_1_4; pfam13701 471223003754 putative inner membrane protein; Provisional; Region: PRK11099 471223003755 Sulphur transport; Region: Sulf_transp; cl01018 471223003756 putative inner membrane protein; Provisional; Region: PRK11099 471223003757 Sulphur transport; Region: Sulf_transp; cl01018 471223003758 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 471223003759 AAA domain; Region: AAA_21; pfam13304 471223003760 ABC (ATP-binding cassette) transporter nucleotide-binding domain; ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars, ions, peptides, and more complex organic molecules. The...; Region: ABC_ATPase; cd00267 471223003761 ABC transporter signature motif; other site 471223003762 Walker B; other site 471223003763 D-loop; other site 471223003764 H-loop/switch region; other site 471223003765 Uncharacterized conserved protein [Function unknown]; Region: COG4715 471223003766 Domain of unknown function (DUF3578); Region: DUF3578; pfam12102 471223003767 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 471223003768 Domain of unknown function (DUF2357); Region: DUF2357; pfam09823 471223003769 Protein of unknown function (DUF524); Region: DUF524; pfam04411 471223003770 MazG nucleotide pyrophosphohydrolase domain; Region: MazG; cl00345 471223003771 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; cl14891 471223003772 Integrase core domain; Region: rve; cl01316 471223003773 Putative inner membrane protein (DUF1819); Region: DUF1819; pfam08849 471223003774 Domain of unknown function (DUF1788); Region: DUF1788; pfam08747 471223003775 septation ring formation regulator EzrA; Provisional; Region: PRK04778 471223003776 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 471223003777 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 471223003778 TIGR02687 family protein; Region: TIGR02687 471223003779 PglZ domain; Region: PglZ; pfam08665 471223003780 Superfamily II DNA/RNA helicases, SNF2 family [Transcription / DNA replication, recombination, and repair]; Region: HepA; COG0553 471223003781 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 471223003782 ATP binding site [chemical binding]; other site 471223003783 putative Mg++ binding site [ion binding]; other site 471223003784 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 471223003785 nucleotide binding region [chemical binding]; other site 471223003786 ATP-binding site [chemical binding]; other site 471223003787 AAA ATPase domain; Region: AAA_15; pfam13175 471223003788 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 471223003789 Walker A/P-loop; other site 471223003790 ATP binding site [chemical binding]; other site 471223003791 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 471223003792 ABC transporter signature motif; other site 471223003793 Walker B; other site 471223003794 D-loop; other site 471223003795 H-loop/switch region; other site 471223003796 conserved hypothetical protein (putative transposase or invertase); Region: T_den_put_tspse; TIGR01784 471223003797 Putative transposase, YhgA-like; Region: Transposase_31; pfam04754 471223003798 Restriction endonuclease; Region: Mrr_cat; cl00516 471223003799 DNA topoisomerase I, bacterial; Region: topA_bact; TIGR01051 471223003800 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 471223003801 Domain of unknown function (DUF4143); Region: DUF4143; pfam13635 471223003802 gamma-aminobutyrate permease; Region: GABAperm; TIGR01773 471223003803 Purine catabolism regulatory protein-like family; Region: PucR; pfam07905 471223003804 Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508 471223003805 Helix-turn-helix domains; Region: HTH; cl00088 471223003806 Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085 471223003807 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 471223003808 tetrameric interface [polypeptide binding]; other site 471223003809 NAD binding site [chemical binding]; other site 471223003810 catalytic residues [active] 471223003811 aminotransferase; Validated; Region: PRK07678 471223003812 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 471223003813 inhibitor-cofactor binding pocket; inhibition site 471223003814 pyridoxal 5'-phosphate binding site [chemical binding]; other site 471223003815 catalytic residue [active] 471223003816 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 471223003817 putative active site [active] 471223003818 Haemagglutinin; Region: Hemagglutinin; pfam00509 471223003819 Transposase; Region: DEDD_Tnp_IS110; pfam01548 471223003820 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 471223003821 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 471223003822 Probable transposase; Region: OrfB_IS605; pfam01385 471223003823 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 471223003824 Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282 471223003825 SNF2 Helicase protein; Region: DUF3670; pfam12419 471223003826 SNF2 family N-terminal domain; Region: SNF2_N; pfam00176 471223003827 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 471223003828 ATP binding site [chemical binding]; other site 471223003829 putative Mg++ binding site [ion binding]; other site 471223003830 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 471223003831 nucleotide binding region [chemical binding]; other site 471223003832 ATP-binding site [chemical binding]; other site 471223003833 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 471223003834 Probable transposase; Region: OrfB_IS605; pfam01385 471223003835 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 471223003836 Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282 471223003837 Protein of unknown function (DUF3986); Region: DUF3986; pfam13143 471223003838 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 471223003839 putative active site [active] 471223003840 Haemagglutinin; Region: Hemagglutinin; pfam00509 471223003841 Phage integrase, N-terminal SAM-like domain; Region: Phage_integr_N; cl12235 471223003842 Acetamidase/Formamidase family; Region: FmdA_AmdA; cl01023 471223003843 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 471223003844 Amidase; Region: Amidase; cl11426 471223003845 Yhfp putative quinone oxidoreductases; Region: MDR_yhfp_like; cd08289 471223003846 putative quinone oxidoreductase, YhdH/YhfP family; Region: oxido_YhdH; TIGR02823 471223003847 putative NADP binding site [chemical binding]; other site 471223003848 putative dimer interface [polypeptide binding]; other site 471223003849 dihydroxyacetone kinase subunit DhaK; Provisional; Region: PRK14481; cl10557 471223003850 Dihydroxyacetone kinase [Carbohydrate transport and metabolism]; Region: DAK1; COG2376 471223003851 DAK2 domain; Region: Dak2; cl03685 471223003852 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cl00025 471223003853 Transcriptional regulator [Transcription]; Region: LysR; COG0583 471223003854 Helix-turn-helix domains; Region: HTH; cl00088 471223003855 The substrate binding domain of LysR-type transcriptional regulator GltC, which activates gltA expression of glutamate synthase operon, contains type 2 periplasmic binding fold; Region: PBP2_GltC_like; cd08434 471223003856 putative dimerization interface [polypeptide binding]; other site 471223003857 glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750 471223003858 Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713 471223003859 active site 471223003860 dimer interface [polypeptide binding]; other site 471223003861 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 471223003862 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 471223003863 active site 471223003864 FMN binding site [chemical binding]; other site 471223003865 substrate binding site [chemical binding]; other site 471223003866 3Fe-4S cluster binding site [ion binding]; other site 471223003867 gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982 471223003868 domain interface; other site 471223003869 glutamate synthase subunit beta; Reviewed; Region: gltD; PRK12810 471223003870 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 471223003871 OsmC-like protein; Region: OsmC; cl00767 471223003872 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 471223003873 MoaE interaction surface [polypeptide binding]; other site 471223003874 MoeB interaction surface [polypeptide binding]; other site 471223003875 thiocarboxylated glycine; other site 471223003876 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 471223003877 MoaE homodimer interface [polypeptide binding]; other site 471223003878 MoaD interaction [polypeptide binding]; other site 471223003879 active site residues [active] 471223003880 molybdenum cofactor biosynthesis protein A, bacterial; Region: moaA; TIGR02666 471223003881 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 471223003882 FeS/SAM binding site; other site 471223003883 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 471223003884 GyrI-like small molecule binding domain; Region: GyrI-like; cl01368 471223003885 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 471223003886 active site 471223003887 Predicted membrane protein [Function unknown]; Region: COG4984 471223003888 Predicted membrane protein (DUF2157); Region: DUF2157; cl10480 471223003889 GDYXXLXY protein; Region: GDYXXLXY; cl02066 471223003890 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 471223003891 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 471223003892 Immune inhibitor A peptidase M6; Region: Peptidase_M6; cl11525 471223003893 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 471223003894 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971 471223003895 Glycosyl hydrolase family 3 C-terminal domain; Region: Glyco_hydro_3_C; pfam01915 471223003896 Protein of unknown function (DUF1343); Region: DUF1343; cl01598 471223003897 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 471223003898 Transposase; Region: DDE_Tnp_ISL3; pfam01610 471223003899 Transposase; Region: DEDD_Tnp_IS110; pfam01548 471223003900 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 471223003901 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: APH_ChoK_like; cd05120 471223003902 Phosphotransferase enzyme family; Region: APH; pfam01636 471223003903 active site 471223003904 ATP binding site [chemical binding]; other site 471223003905 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 471223003906 NAD-dependent deacetylase; Provisional; Region: PRK00481 471223003907 SIR2_Af2: Archaeal and prokaryotic group which includes Archaeoglobus fulgidus Sir2-Af2, Sulfolobus solfataricus ssSir2, and several bacterial homologs; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which...; Region: SIR2_Af2; cd01413 471223003908 NAD+ binding site [chemical binding]; other site 471223003909 substrate binding site [chemical binding]; other site 471223003910 Zn binding site [ion binding]; other site 471223003911 intracellular protease, PfpI family; Region: PfpI; TIGR01382 471223003912 Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_1; cd03169 471223003913 conserved cys residue [active] 471223003914 EamA-like transporter family; Region: EamA; cl01037 471223003915 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 471223003916 EamA-like transporter family; Region: EamA; cl01037 471223003917 Predicted dithiol-disulfide isomerase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FrnE; COG2761 471223003918 DsbA family, FrnE subfamily; FrnE is a DsbA-like protein containing a CXXC motif. It is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the aromatic antibiotics frenolicin and nanaomycins; Region: DsbA_FrnE; cd03024 471223003919 catalytic residues [active] 471223003920 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 471223003921 Malic enzyme, N-terminal domain; Region: malic; pfam00390 471223003922 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 471223003923 putative NAD(P) binding site [chemical binding]; other site 471223003924 Nucleotidyltransferase substrate binding protein like; Region: NTase_sub_bind; cl08495 471223003925 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 471223003926 active site 471223003927 NTP binding site [chemical binding]; other site 471223003928 metal binding triad [ion binding]; metal-binding site 471223003929 antibiotic binding site [chemical binding]; other site 471223003930 Uncharacterized conserved protein [Function unknown]; Region: COG4127 471223003931 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 471223003932 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 471223003933 McrBC 5-methylcytosine restriction system component; Region: McrBC; cl01737 471223003934 Transposase domain (DUF772); Region: DUF772; cl15789 471223003935 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 471223003936 Glycerol-3-phosphate responsive antiterminator; Region: G3P_antiterm; cl00852 471223003937 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 471223003938 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 471223003939 Walker A/P-loop; other site 471223003940 ATP binding site [chemical binding]; other site 471223003941 Q-loop/lid; other site 471223003942 ABC transporter signature motif; other site 471223003943 Walker B; other site 471223003944 D-loop; other site 471223003945 H-loop/switch region; other site 471223003946 TOBE domain; Region: TOBE_2; cl01440 471223003947 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 471223003948 dimer interface [polypeptide binding]; other site 471223003949 conserved gate region; other site 471223003950 putative PBP binding loops; other site 471223003951 ABC-ATPase subunit interface; other site 471223003952 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 471223003953 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 471223003954 dimer interface [polypeptide binding]; other site 471223003955 conserved gate region; other site 471223003956 putative PBP binding loops; other site 471223003957 ABC-ATPase subunit interface; other site 471223003958 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 471223003959 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 471223003960 Glycerophosphodiester phosphodiesterase domain of Thermoanaerobacter tengcongensis and similar proteins; Region: GDPD_TtGDE_like; cd08563 471223003961 Glycerophosphoryl diester phosphodiesterase family; Region: GDPD; pfam03009 471223003962 active site 471223003963 catalytic site [active] 471223003964 metal binding site [ion binding]; metal-binding site 471223003965 dimer interface [polypeptide binding]; other site 471223003966 putative fructoselysine transporter; Provisional; Region: frlA; PRK11357 471223003967 Spore germination protein; Region: Spore_permease; cl15802 471223003968 Cache domain; Region: Cache_1; pfam02743 471223003969 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 471223003970 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 471223003971 dimerization interface [polypeptide binding]; other site 471223003972 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 471223003973 phosphorylation site [posttranslational modification] 471223003974 dimer interface [polypeptide binding]; other site 471223003975 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 471223003976 ATP binding site [chemical binding]; other site 471223003977 Mg2+ binding site [ion binding]; other site 471223003978 G-X-G motif; other site 471223003979 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 471223003980 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 471223003981 intersubunit interface [polypeptide binding]; other site 471223003982 ABC component of the metal-type transporters. This family includes transporters involved in the uptake of various metallic cations such as iron, manganese, and zinc. The ATPases of this group of transporters are very similar to members of...; Region: ABC_Metallic_Cations; cd03235 471223003983 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 471223003984 ABC component of the metal-type transporters. This family includes transporters involved in the uptake of various metallic cations such as iron, manganese, and zinc. The ATPases of this group of transporters are very similar to members of...; Region: ABC_Metallic_Cations; cd03235 471223003985 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 471223003986 ABC-ATPase subunit interface; other site 471223003987 dimer interface [polypeptide binding]; other site 471223003988 putative PBP binding regions; other site 471223003989 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 471223003990 ABC-ATPase subunit interface; other site 471223003991 dimer interface [polypeptide binding]; other site 471223003992 putative PBP binding regions; other site 471223003993 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 471223003994 Probable transposase; Region: OrfB_IS605; pfam01385 471223003995 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 471223003996 Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282 471223003997 DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808 471223003998 Uncharacterized conserved protein [Function unknown]; Region: COG4127 471223003999 Restriction endonuclease; Region: Mrr_cat; cl00516 471223004000 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 471223004001 Helix-turn-helix domains; Region: HTH; cl00088 471223004002 PRD domain; Region: PRD; cl15445 471223004003 PRD domain; Region: PRD; cl15445 471223004004 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 471223004005 P-loop; other site 471223004006 active site 471223004007 phosphorylation site [posttranslational modification] 471223004008 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 471223004009 active site 471223004010 phosphorylation site [posttranslational modification] 471223004011 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 471223004012 active site 471223004013 phosphorylation site [posttranslational modification] 471223004014 PTS_IIB_ascorbate: subunit IIB of enzyme II (EII) of the L-ascorbate-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is an L-ascorbate-specific permease with two cytoplasmic subunits (IIA and IIB) and a...; Region: PTS_IIB_ascorbate; cd05563 471223004015 P-loop; other site 471223004016 active site 471223004017 phosphorylation site [posttranslational modification] 471223004018 PTS system sugar-specific permease component; Region: EIIC-GAT; cl04451 471223004019 Phosphotriesterase (PTE) catalyzes the hydrolysis of organophosphate nerve agents, including the chemical warfare agents VX, soman, and sarin as well as the insecticide paraoxon. PTE exists as a homodimer with one active site per monomer. The active site...; Region: PTE; cd00530 471223004020 active site 471223004021 substrate binding pocket [chemical binding]; other site 471223004022 homodimer interaction site [polypeptide binding]; other site 471223004023 Creatinine amidohydrolase; Region: Creatininase; cl00618 471223004024 Protein of unknown function (DUF1341); Region: DUF1341; cl06211 471223004025 hypothetical protein; Provisional; Region: PRK02947 471223004026 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 471223004027 putative active site [active] 471223004028 Transposase DDE domain group 1; Region: DDE_Tnp_1_4; pfam13701 471223004029 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 471223004030 Uncharacterized protein family (UPF0236); Region: UPF0236; pfam06782 471223004031 Bacterial aspartate proteases, retropepsin-like protease family; Region: retropepsin_like_bacteria; cd05483 471223004032 catalytic motif [active] 471223004033 Catalytic residue [active] 471223004034 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 471223004035 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 471223004036 DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808 471223004037 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; cl14891 471223004038 Integrase core domain; Region: rve; cl01316 471223004039 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 471223004040 Predicted dehydrogenase [General function prediction only]; Region: COG0579 471223004041 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 471223004042 Transposase; Region: DDE_Tnp_ISL3; pfam01610 471223004043 Branched-chain amino acid transport protein; Region: Branch_AA_trans; cl00547 471223004044 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 471223004045 Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548 471223004046 PCD_DCoH: The bifunctional protein pterin-4alpha-carbinolamine dehydratase (PCD), also known as DCoH (dimerization cofactor of hepatocyte nuclear factor-1), is both a transcription activator and a metabolic enzyme. DCoH stimulates gene expression by...; Region: PCD_DCoH; cd00488 471223004047 aromatic arch; other site 471223004048 DCoH dimer interaction site [polypeptide binding]; other site 471223004049 DCoH /HNF-1 dimer interaction site [polypeptide binding]; other site 471223004050 DCoH tetramer interaction site [polypeptide binding]; other site 471223004051 substrate binding site [chemical binding]; other site 471223004052 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 471223004053 Pyridoxal-phosphate dependent enzyme; Region: PALP; pfam00291 471223004054 pyridoxal 5'-phosphate binding site [chemical binding]; other site 471223004055 catalytic residue [active] 471223004056 ABC-2 type transporter; Region: ABC2_membrane; cl11417 471223004057 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 471223004058 Helix-turn-helix domains; Region: HTH; cl00088 471223004059 Na+/H+ antiporter [Energy production and conversion]; Region: NhaC; COG1757 471223004060 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 471223004061 transposase, putative, N-terminal domain; Region: tspaseT_teng_N; TIGR01765 471223004062 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 471223004063 Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282 471223004064 Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917 471223004065 NodB motif; other site 471223004066 active site 471223004067 catalytic site [active] 471223004068 metal binding site [ion binding]; metal-binding site 471223004069 Formate/nitrite transporter; Region: Form_Nir_trans; cl00927 471223004070 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 471223004071 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 471223004072 DNA-binding site [nucleotide binding]; DNA binding site 471223004073 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 471223004074 pyridoxal 5'-phosphate binding site [chemical binding]; other site 471223004075 homodimer interface [polypeptide binding]; other site 471223004076 catalytic residue [active] 471223004077 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; cl14891 471223004078 Integrase core domain; Region: rve; cl01316 471223004079 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 471223004080 Protein of unknown function, DUF606; Region: DUF606; cl01273 471223004081 IDEAL domain; Region: IDEAL; cl07452 471223004082 Transcriptional regulators [Transcription]; Region: PurR; COG1609 471223004083 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 471223004084 DNA binding site [nucleotide binding] 471223004085 domain linker motif; other site 471223004086 Ligand-binding domain of uncharacterized DNA-binding regulatory proteins that are members of the LacI-GalR family of bacterial transcription repressors; Region: PBP1_LacI_like_1; cd06277 471223004087 putative dimerization interface [polypeptide binding]; other site 471223004088 putative ligand binding site [chemical binding]; other site 471223004089 Domain of unknown function (DUF377); Region: DUF377; pfam04041 471223004090 Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647 471223004091 active site 471223004092 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 471223004093 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 471223004094 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 471223004095 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 471223004096 putative PBP binding loops; other site 471223004097 dimer interface [polypeptide binding]; other site 471223004098 ABC-ATPase subunit interface; other site 471223004099 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 471223004100 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 471223004101 dimer interface [polypeptide binding]; other site 471223004102 conserved gate region; other site 471223004103 putative PBP binding loops; other site 471223004104 ABC-ATPase subunit interface; other site 471223004105 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; cl08371 471223004106 Beta-galactosidase/beta-glucuronidase [Carbohydrate transport and metabolism]; Region: LacZ; COG3250 471223004107 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 471223004108 Cellulase (glycosyl hydrolase family 5); Region: Cellulase; cl15381 471223004109 YceI-like domain; Region: YceI; cl01001 471223004110 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 471223004111 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 471223004112 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 471223004113 putative active site [active] 471223004114 N-acetylmuramic acid-6-phosphate etherase; Reviewed; Region: murQ; PRK05441 471223004115 N-acetylmuramic acid 6-phosphate etherase. Members of this family contain the SIS (Sugar ISomerase) domain. The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. The bacterial cell wall sugar N-acetylmuramic acid...; Region: SIS_Etherase; cd05007 471223004116 putative active site [active] 471223004117 PTS system, sucrose-specific IIBC component; Region: PTS-II-BC-sucr; TIGR01996 471223004118 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 471223004119 active site turn [active] 471223004120 phosphorylation site [posttranslational modification] 471223004121 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; cl00557 471223004122 Bacterial protein of unknown function (DUF871); Region: DUF871; cl15404 471223004123 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 471223004124 Response regulator receiver domain; Region: Response_reg; pfam00072 471223004125 active site 471223004126 phosphorylation site [posttranslational modification] 471223004127 intermolecular recognition site; other site 471223004128 dimerization interface [polypeptide binding]; other site 471223004129 YcbB domain; Region: YcbB; pfam08664 471223004130 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 471223004131 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 471223004132 ATP binding site [chemical binding]; other site 471223004133 G-X-G motif; other site 471223004134 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 471223004135 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 471223004136 dimer interface [polypeptide binding]; other site 471223004137 conserved gate region; other site 471223004138 putative PBP binding loops; other site 471223004139 ABC-ATPase subunit interface; other site 471223004140 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 471223004141 dimer interface [polypeptide binding]; other site 471223004142 conserved gate region; other site 471223004143 putative PBP binding loops; other site 471223004144 ABC-ATPase subunit interface; other site 471223004145 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 471223004146 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 471223004147 substrate binding pocket [chemical binding]; other site 471223004148 membrane-bound complex binding site; other site 471223004149 hinge residues; other site 471223004150 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 471223004151 HisP and GlnQ are the ATP-binding components of the bacterial periplasmic histidine and glutamine permeases, repectively. Histidine permease is a multisubunit complex containing the HisQ and HisM integral membrane subunits and two copies of HisP. HisP...; Region: ABC_HisP_GlnQ_permeases; cd03262 471223004152 Walker A/P-loop; other site 471223004153 ATP binding site [chemical binding]; other site 471223004154 Q-loop/lid; other site 471223004155 ABC transporter signature motif; other site 471223004156 Walker B; other site 471223004157 D-loop; other site 471223004158 H-loop/switch region; other site 471223004159 Membrane transport protein; Region: Mem_trans; cl09117 471223004160 Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cd00016 471223004161 Alkaline phosphatase homologues; Region: alkPPc; smart00098 471223004162 active site 471223004163 dimer interface [polypeptide binding]; other site 471223004164 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 471223004165 Uncharacterized protein family (UPF0236); Region: UPF0236; pfam06782 471223004166 Transcriptional regulators [Transcription]; Region: PurR; COG1609 471223004167 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 471223004168 DNA binding site [nucleotide binding] 471223004169 domain linker motif; other site 471223004170 Ligand-binding domain of DNA transcription repressor RegR and other putative regulators such as KdgR and EndR; Region: PBP1_RegR_EndR_KdgR_like; cd06283 471223004171 putative dimerization interface [polypeptide binding]; other site 471223004172 putative ligand binding site [chemical binding]; other site 471223004173 gluconate kinase, FGGY type; Region: gntK_FGGY; TIGR01314 471223004174 gluconate kinases; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_GntK; cd07770 471223004175 N- and C-terminal domain interface [polypeptide binding]; other site 471223004176 putative active site [active] 471223004177 catalytic site [active] 471223004178 metal binding site [ion binding]; metal-binding site 471223004179 carbohydrate binding site [chemical binding]; other site 471223004180 ATP binding site [chemical binding]; other site 471223004181 Na+-H+ antiporter family; Region: Na_H_antiport_2; cl15264 471223004182 GntP family permease; Region: GntP_permease; pfam02447 471223004183 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 471223004184 Coenzyme A binding pocket [chemical binding]; other site 471223004185 pseudaminic acid biosynthesis N-acetyl transferase; Region: PseH; TIGR03585 471223004186 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 471223004187 Uncharacterized ALDH (y4uC) with similarity to Tortula ruralis aldehyde dehydrogenase ALDH21A1; Region: ALDH_y4uC; cd07149 471223004188 NAD(P) binding site [chemical binding]; other site 471223004189 catalytic residues [active] 471223004190 enoyl-CoA hydratase; Provisional; Region: PRK07659 471223004191 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 471223004192 substrate binding site [chemical binding]; other site 471223004193 oxyanion hole (OAH) forming residues; other site 471223004194 trimer interface [polypeptide binding]; other site 471223004195 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 471223004196 putative active site [active] 471223004197 Domain of unknown function DUF20; Region: UPF0118; pfam01594 471223004198 pheromone autoinducer 2 transporter; Reviewed; Region: tqsA; cl00465 471223004199 Transcriptional regulator containing PAS, AAA-type ATPase, and DNA-binding domains [Transcription / Signal transduction mechanisms]; Region: RocR; COG3829 471223004200 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 471223004201 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 471223004202 putative active site [active] 471223004203 heme pocket [chemical binding]; other site 471223004204 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 471223004205 Walker A motif; other site 471223004206 ATP binding site [chemical binding]; other site 471223004207 Walker B motif; other site 471223004208 arginine finger; other site 471223004209 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 471223004210 Uncharacterized ALDH (y4uC) with similarity to Tortula ruralis aldehyde dehydrogenase ALDH21A1; Region: ALDH_y4uC; cd07149 471223004211 NAD(P) binding site [chemical binding]; other site 471223004212 catalytic residues [active] 471223004213 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 471223004214 Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872 471223004215 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 471223004216 active site 471223004217 NAD binding site [chemical binding]; other site 471223004218 metal binding site [ion binding]; metal-binding site 471223004219 Protein of unknown function (DUF3940); Region: DUF3940; pfam13076 471223004220 DDE superfamily endonuclease; Region: DDE_5; cl02413 471223004221 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 471223004222 Archaeal putative transposase ISC1217; Region: DDE_Tnp_2; pfam04693 471223004223 Helix-Turn-Helix DNA binding domain of GlnR-like transcription regulators; Region: HTH_GlnR-like; cd01105 471223004224 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 471223004225 DNA binding residues [nucleotide binding] 471223004226 putative dimer interface [polypeptide binding]; other site 471223004227 Endonuclease I; Region: Endonuclease_1; cl01003 471223004228 bile acid transporter; Region: bass; TIGR00841 471223004229 Membrane transport protein; Region: Mem_trans; cl09117 471223004230 FeoA domain; Region: FeoA; cl00838 471223004231 Fe2+ transport system protein B [Inorganic ion transport and metabolism]; Region: FeoB; COG0370 471223004232 Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879 471223004233 G1 box; other site 471223004234 GTP/Mg2+ binding site [chemical binding]; other site 471223004235 Switch I region; other site 471223004236 G2 box; other site 471223004237 G3 box; other site 471223004238 Switch II region; other site 471223004239 G4 box; other site 471223004240 G5 box; other site 471223004241 Nucleoside recognition; Region: Gate; cl00486 471223004242 Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664 471223004243 Nucleoside recognition; Region: Gate; cl00486 471223004244 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 471223004245 Helix-turn-helix domains; Region: HTH; cl00088 471223004246 SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339 471223004247 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105 471223004248 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 471223004249 putative substrate binding site [chemical binding]; other site 471223004250 putative ATP binding site [chemical binding]; other site 471223004251 PTS system 2-O-a-mannosyl-D-glycerate specific transporter subunit IIABC; Provisional; Region: PRK09765 471223004252 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 471223004253 active site 471223004254 phosphorylation site [posttranslational modification] 471223004255 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 471223004256 P-loop; other site 471223004257 active site 471223004258 phosphorylation site [posttranslational modification] 471223004259 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; cl00557 471223004260 Helix-turn-helix domains; Region: HTH; cl00088 471223004261 Domain of unknown function (DUF4277); Region: DUF4277; pfam14104 471223004262 Transposase [DNA replication, recombination, and repair]; Region: COG5421 471223004263 Integrase core domain; Region: rve; cl01316 471223004264 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 471223004265 Transposase domain (DUF772); Region: DUF772; cl15789 471223004266 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 471223004267 Transposase domain (DUF772); Region: DUF772; cl15789 471223004268 Predicted permeases [General function prediction only]; Region: COG0701 471223004269 Predicted permease; Region: DUF318; pfam03773 471223004270 Domain of unknown function (DUF1980); Region: DUF1980; cl01492 471223004271 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 471223004272 Uncharacterized protein family UPF0047; Region: UPF0047; cl00439 471223004273 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 471223004274 active site 471223004275 ECF-type riboflavin transporter, S component; Region: ECF-ribofla_trS; cl01942 471223004276 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 471223004277 dimer interface [polypeptide binding]; other site 471223004278 phosphorylation site [posttranslational modification] 471223004279 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 471223004280 ATP binding site [chemical binding]; other site 471223004281 Mg2+ binding site [ion binding]; other site 471223004282 G-X-G motif; other site 471223004283 uroporphyrinogen-III synthase; Reviewed; Region: hemD; PRK05928 471223004284 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 471223004285 active site 471223004286 Hemerythrin (Hr) is a non-heme diiron oxygen transport protein found in four marine invertebrate phyla including priapulida, brachiopoda, sipunculida, and annelida, as well as in protozoa. Myohemerythrin (Mhr), a hemerythrin homolog, is found in the...; Region: Hemerythrin; cl15774 471223004287 Nitrate reductase gamma subunit; Region: Nitrate_red_gam; cl00959 471223004288 Nitrate reductase delta subunit; Region: Nitrate_red_del; cl00958 471223004289 respiratory nitrate reductase, alpha subunit; Region: narG; TIGR01580 471223004290 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_Nitrate-R-NarG-like; cd02750 471223004291 [4Fe-4S] binding site [ion binding]; other site 471223004292 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 471223004293 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 471223004294 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 471223004295 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_CT_Nitrate-R-NarG-like; cd02776 471223004296 molybdopterin cofactor binding site; other site 471223004297 Predicted membrane-bound metal-dependent hydrolase (DUF457); Region: DUF457; cl00868 471223004298 60Kd inner membrane protein; Region: 60KD_IMP; cl00489 471223004299 Isochorismatase family; Region: Isochorismatase; pfam00857 471223004300 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 471223004301 catalytic triad [active] 471223004302 conserved cis-peptide bond; other site 471223004303 nicotinate phosphoribosyltransferase; Validated; Region: PRK09243 471223004304 Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570 471223004305 active site 471223004306 oligoendopeptidase F; Region: pepF; TIGR00181 471223004307 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_3; cd09608 471223004308 active site 471223004309 Zn binding site [ion binding]; other site 471223004310 Transposase; Region: DEDD_Tnp_IS110; pfam01548 471223004311 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 471223004312 Demethylmenaquinone methyltransferase; Region: Methyltransf_6; cl00480 471223004313 Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980 471223004314 dimer interface [polypeptide binding]; other site 471223004315 [2Fe-2S] cluster binding site [ion binding]; other site 471223004316 Cobalt uptake substrate-specific transmembrane region; Region: CbiM; cl00397 471223004317 Cobalt transport protein component CbiN; Region: CbiN; cl00842 471223004318 Cobalt transport protein; Region: CbiQ; cl00463 471223004319 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 471223004320 Domain I of the ABC component of a cobalt transport family found in bacteria, archaea, and eukaryota. The transition metal cobalt is an essential component of many enzymes and must be transported into cells in appropriate amounts when needed. This ABC...; Region: ABC_cobalt_CbiO_domain1; cd03225 471223004321 Walker A/P-loop; other site 471223004322 ATP binding site [chemical binding]; other site 471223004323 Q-loop/lid; other site 471223004324 ABC transporter signature motif; other site 471223004325 Walker B; other site 471223004326 D-loop; other site 471223004327 H-loop/switch region; other site 471223004328 Tetrapyrrole (Corrin/Porphyrin) Methylases; Region: TP_methylase; pfam00590 471223004329 Precorrin-3B methylase [Coenzyme metabolism]; Region: CobJ; cl00304 471223004330 Nitrite and sulphite reductase 4Fe-4S domain; Region: NIR_SIR; pfam01077 471223004331 Sirohydrochlorin ferrochelatase [Inorganic ion transport and metabolism]; Region: COG2138 471223004332 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_N; cd03416 471223004333 putative active site [active] 471223004334 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), C-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_C; cd03414 471223004335 putative active site [active] 471223004336 Transposase; Region: DEDD_Tnp_IS110; pfam01548 471223004337 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 471223004338 Precorrin-6x reductase [Coenzyme metabolism]; Region: CobK; COG2099 471223004339 Precorrin-6x reductase CbiJ/CobK; Region: CbiJ; cl00922 471223004340 Precorrin isomerase [Coenzyme metabolism]; Region: CobH; cl00913 471223004341 Precorrin-8X methylmutase; Region: CbiC; pfam02570 471223004342 CbiD; Region: CbiD; cl00828 471223004343 Tetrapyrrole (Corrin/Porphyrin) Methylases; Region: TP_methylase; pfam00590 471223004344 Precorrin-3B methylase [Coenzyme metabolism]; Region: CobJ; cl00304 471223004345 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl15754 471223004346 cobalt-precorrin-6Y C(15)-methyltransferase; Validated; Region: PRK08287 471223004347 Precorrin-3B methylase [Coenzyme metabolism]; Region: CobJ; cl00304 471223004348 Tetrapyrrole (Corrin/Porphyrin) Methylases; Region: TP_methylase; pfam00590 471223004349 Tetrapyrrole (Corrin/Porphyrin) Methylases; Region: TP_methylase; pfam00590 471223004350 Precorrin-3B methylase [Coenzyme metabolism]; Region: CobJ; cl00304 471223004351 cobalamin biosynthesis protein CbiG; Validated; Region: PRK05788 471223004352 Cobalamin synthesis G N-terminal; Region: CbiG_N; pfam11760 471223004353 Cobalamin biosynthesis central region; Region: CbiG_mid; pfam11761 471223004354 Cobalamin synthesis G C-terminus; Region: CbiG_C; cl12133 471223004355 cobyrinic acid a,c-diamide synthase; Validated; Region: PRK01077 471223004356 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 471223004357 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyrinic Acid a,c-Diamide Synthase; Region: GATase1_CobB; cd03130 471223004358 catalytic triad [active] 471223004359 cobyric acid synthase; Provisional; Region: PRK00784 471223004360 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 471223004361 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 471223004362 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 471223004363 catalytic triad [active] 471223004364 Phosphoribosyltransferase; Region: DBI_PRT; pfam02277 471223004365 Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (DMB-PRT), also called CobT; Region: DMB-PRT_CobT; cd02439 471223004366 putative dimer interface [polypeptide binding]; other site 471223004367 active site pocket [active] 471223004368 putative cataytic base [active] 471223004369 Precorrin-3B methylase [Coenzyme metabolism]; Region: CobJ; cl00304 471223004370 Tetrapyrrole (Corrin/Porphyrin) Methylases; Region: TP_methylase; pfam00590 471223004371 ATP:corrinoid adenosyltransferase BtuR/CobO/CobP. This family consists of the BtuR, CobO, CobP proteins all of which are Cob(I)alamin (vitamin B12) adenosyltransferase, which is involved in cobalamin (vitamin B12) biosynthesis. This enzyme is a homodimer; Region: CobA_CobO_BtuR; cd00561 471223004372 homodimer interface [polypeptide binding]; other site 471223004373 Walker A motif; other site 471223004374 ATP binding site [chemical binding]; other site 471223004375 hydroxycobalamin binding site [chemical binding]; other site 471223004376 Walker B motif; other site 471223004377 Protein of unknown function (DUF3892); Region: DUF3892; pfam13031 471223004378 Methyltransferase domain; Region: Methyltransf_31; pfam13847 471223004379 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 471223004380 S-adenosylmethionine binding site [chemical binding]; other site 471223004381 Homoserine O-succinyltransferase; Region: HTS; pfam04204 471223004382 Type 1 glutamine amidotransferase (GATase1)-like domain found in homoserine trans-succinylase (HTS); Region: GATase1_HTS; cd03131 471223004383 proposed active site lysine [active] 471223004384 conserved cys residue [active] 471223004385 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 471223004386 catalytic residues [active] 471223004387 dimer interface [polypeptide binding]; other site 471223004388 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 471223004389 Domain I of the ABC component of a cobalt transport family found in bacteria, archaea, and eukaryota. The transition metal cobalt is an essential component of many enzymes and must be transported into cells in appropriate amounts when needed. This ABC...; Region: ABC_cobalt_CbiO_domain1; cd03225 471223004390 Walker A/P-loop; other site 471223004391 ATP binding site [chemical binding]; other site 471223004392 Q-loop/lid; other site 471223004393 ABC transporter signature motif; other site 471223004394 Walker B; other site 471223004395 D-loop; other site 471223004396 H-loop/switch region; other site 471223004397 ABC transporter; Region: ABC_tran_2; pfam12848 471223004398 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 471223004399 Scaffold protein Nfu/NifU N terminal; Region: Nfu_N; cl07364 471223004400 Virulence factor; Region: Virulence_fact; pfam13769 471223004401 FOG: HEAT repeat [Energy production and conversion]; Region: COG1413 471223004402 PBS lyase HEAT-like repeat; Region: HEAT_PBS; cl15388 471223004403 PBS lyase HEAT-like repeat; Region: HEAT_PBS; cl15388 471223004404 Disulphide isomerase; Region: Disulph_isomer; pfam06491 471223004405 YuzL-like protein; Region: YuzL; pfam14115 471223004406 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 471223004407 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 471223004408 transposase, putative, N-terminal domain; Region: tspaseT_teng_N; TIGR01765 471223004409 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 471223004410 Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282 471223004411 YpjP-like protein; Region: YpjP; pfam14005 471223004412 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 471223004413 dimerization interface [polypeptide binding]; other site 471223004414 active site 471223004415 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 471223004416 folate binding site [chemical binding]; other site 471223004417 NADP+ binding site [chemical binding]; other site 471223004418 Protein of unknown function (DUF2512); Region: DUF2512; pfam10710 471223004419 threonine dehydratase; Validated; Region: PRK08639 471223004420 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 471223004421 tetramer interface [polypeptide binding]; other site 471223004422 pyridoxal 5'-phosphate binding site [chemical binding]; other site 471223004423 catalytic residue [active] 471223004424 Second of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_2; cd04907 471223004425 putative Ile/Val binding site [chemical binding]; other site 471223004426 Protein of unknown function (DUF2535); Region: DUF2535; pfam10751 471223004427 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 471223004428 transposase, putative, N-terminal domain; Region: tspaseT_teng_N; TIGR01765 471223004429 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 471223004430 Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282 471223004431 Uncharacterized protein, DegV family COG1307; Region: DegV; cl00577 471223004432 SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968 471223004433 Cu(I) binding site [ion binding]; other site 471223004434 Members of the SGNH-hydrolase superfamily, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_YpmR_like; cd04506 471223004435 active site 471223004436 catalytic triad [active] 471223004437 oxyanion hole [active] 471223004438 Uncharacterized protein conserved in bacteria (DUF2140); Region: DUF2140; cl11548 471223004439 tRNA and rRNA cytosine-C5-methylases [Translation, ribosomal structure and biogenesis]; Region: Sun; COG0144 471223004440 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 471223004441 S-adenosylmethionine binding site [chemical binding]; other site 471223004442 pre-rRNA processing and ribosome biogenesis; Region: Nol1_Nop2_Fmu_2; cl01283 471223004443 Glycerol-3-phosphate acyltransferase; Region: G3P_acyltransf; cl00410 471223004444 OsmC-like protein; Region: OsmC; cl00767 471223004445 peptidase T; Region: peptidase-T; TIGR01882 471223004446 M20 Peptidase T specifically cleaves tripeptides; Region: M20_peptT; cd03892 471223004447 metal binding site [ion binding]; metal-binding site 471223004448 dimer interface [polypeptide binding]; other site 471223004449 ECF-type riboflavin transporter, S component; Region: ECF-ribofla_trS; cl01942 471223004450 Protein of unknown function (DUF3816); Region: DUF3816; pfam12822 471223004451 bacterial and archael members of the sulfite oxidase (SO) family of molybdopterin binding domains. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and...; Region: arch_bact_SO_family_Moco; cd02109 471223004452 Moco binding site; other site 471223004453 metal coordination site [ion binding]; other site 471223004454 Predicted acetyltransferase [General function prediction only]; Region: COG3153 471223004455 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 471223004456 Coenzyme A binding pocket [chemical binding]; other site 471223004457 Acetyltransferase (GNAT) domain; Region: Acetyltransf_4; pfam13420 471223004458 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 471223004459 Coenzyme A binding pocket [chemical binding]; other site 471223004460 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 471223004461 Uncharacterized protein family (UPF0157); Region: UPF0157; cl00987 471223004462 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 471223004463 transposase, putative, N-terminal domain; Region: tspaseT_teng_N; TIGR01765 471223004464 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 471223004465 Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282 471223004466 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 471223004467 NADH dehydrogenase subunit 5; Validated; Region: PRK08601 471223004468 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; cl14187 471223004469 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3002 471223004470 Uncharacterized protein conserved in bacteria (DUF2309); Region: DUF2309; pfam10070 471223004471 Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661 471223004472 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 471223004473 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: APH_ChoK_like; cd05120 471223004474 active site 471223004475 ATP binding site [chemical binding]; other site 471223004476 Uncharacterized protein family (UPF0236); Region: UPF0236; pfam06782 471223004477 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 471223004478 DNA topoisomerase IV, B subunit, Gram-positive; Region: parE_Gpos; TIGR01058 471223004479 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 471223004480 ATP binding site [chemical binding]; other site 471223004481 Mg2+ binding site [ion binding]; other site 471223004482 G-X-G motif; other site 471223004483 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 471223004484 anchoring element; other site 471223004485 dimer interface [polypeptide binding]; other site 471223004486 ATP binding site [chemical binding]; other site 471223004487 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 471223004488 active site 471223004489 putative metal-binding site [ion binding]; other site 471223004490 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 471223004491 DNA topoisomerase IV, A subunit, Gram-positive; Region: parC_Gpos; TIGR01061 471223004492 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes in DNA...; Region: TOP4c; cd00187 471223004493 CAP-like domain; other site 471223004494 active site 471223004495 primary dimer interface [polypeptide binding]; other site 471223004496 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 471223004497 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 471223004498 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 471223004499 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 471223004500 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 471223004501 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 471223004502 DNA binding residues [nucleotide binding] 471223004503 PTS system, trehalose-specific IIBC component; Region: PTS-IIBC-Tre; TIGR01992 471223004504 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 471223004505 active site turn [active] 471223004506 phosphorylation site [posttranslational modification] 471223004507 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; cl00557 471223004508 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 471223004509 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 471223004510 Ca binding site [ion binding]; other site 471223004511 active site 471223004512 catalytic site [active] 471223004513 trehalose operon repressor, B. subtilis-type; Region: trehalos_R_Bsub; TIGR02404 471223004514 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 471223004515 DNA-binding site [nucleotide binding]; DNA binding site 471223004516 UTRA domain; Region: UTRA; cl01230 471223004517 Na+/H+ antiporter [Energy production and conversion]; Region: NhaC; COG1757 471223004518 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 471223004519 active site 471223004520 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 471223004521 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 471223004522 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 471223004523 catalytic residue [active] 471223004524 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 471223004525 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 471223004526 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 471223004527 spermidine synthase; Provisional; Region: PRK00811 471223004528 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 471223004529 S-adenosylmethionine binding site [chemical binding]; other site 471223004530 Helix-turn-helix domains; Region: HTH; cl00088 471223004531 Rrf2 family protein; Region: rrf2_super; TIGR00738 471223004532 Peptide methionine sulfoxide reductase; Region: PMSR; cl00366 471223004533 Conserved domain frequently associated with peptide methionine sulfoxide reductase [Posttranslational modification, protein turnover, chaperones]; Region: COG0229 471223004534 methionine sulfoxide reductase B; Provisional; Region: PRK00222; cl15841 471223004535 formyltetrahydrofolate deformylase; Reviewed; Region: purU; PRK06027 471223004536 N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875 471223004537 Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648 471223004538 putative active site [active] 471223004539 putative substrate binding site [chemical binding]; other site 471223004540 putative cosubstrate binding site; other site 471223004541 catalytic site [active] 471223004542 Replication terminator protein; Region: RTP; pfam02334 471223004543 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 471223004544 Walker A motif; other site 471223004545 ATP binding site [chemical binding]; other site 471223004546 Walker B motif; other site 471223004547 arginine finger; other site 471223004548 Nitric oxide reductase activation protein [Inorganic ion transport and metabolism]; Region: NorD; COG4548 471223004549 norD type: Denitrifying bacteria contain both membrane bound and periplasmic nitrate reductases. Denitrification plays a major role in completing the nitrogen cycle by converting nitrate or nitrite to nitrogen gas. The pathway for microbial...; Region: vWA_norD_type; cd01454 471223004550 metal ion-dependent adhesion site (MIDAS); other site 471223004551 Predicted phosphohydrolase (DHH superfamily) [General function prediction only]; Region: COG2404 471223004552 DHH family; Region: DHH; pfam01368 471223004553 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 471223004554 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 471223004555 DNA binding site [nucleotide binding] 471223004556 Int/Topo IB signature motif; other site 471223004557 active site 471223004558 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 471223004559 DNA binding site [nucleotide binding] 471223004560 Int/Topo IB signature motif; other site 471223004561 active site 471223004562 type I site-specific deoxyribonuclease, HsdR family; Region: hsdR; TIGR00348 471223004563 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; cl14958 471223004564 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 471223004565 ATP binding site [chemical binding]; other site 471223004566 putative Mg++ binding site [ion binding]; other site 471223004567 Domain of unknown function (DUF3387); Region: DUF3387; pfam11867 471223004568 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 471223004569 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 471223004570 HsdM N-terminal domain; Region: HsdM_N; pfam12161 471223004571 N-6 DNA Methylase; Region: N6_Mtase; pfam02384 471223004572 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 471223004573 type I site-specific deoxyribonuclease, HsdR family; Region: hsdR; TIGR00348 471223004574 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; cl14958 471223004575 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 471223004576 ATP binding site [chemical binding]; other site 471223004577 putative Mg++ binding site [ion binding]; other site 471223004578 SGT1 protein; Region: SGT1; pfam07093 471223004579 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 471223004580 non-specific DNA binding site [nucleotide binding]; other site 471223004581 salt bridge; other site 471223004582 sequence-specific DNA binding site [nucleotide binding]; other site 471223004583 SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2; cl00195 471223004584 Coatomer (COPI) alpha subunit C-terminus; Region: COPI_C; pfam06957 471223004585 Helix-turn-helix domains; Region: HTH; cl00088 471223004586 Winged helix-turn helix; Region: HTH_29; pfam13551 471223004587 Helix-turn-helix domains; Region: HTH; cl00088 471223004588 Winged helix-turn helix; Region: HTH_33; pfam13592 471223004589 Integrase core domain; Region: rve; cl01316 471223004590 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 471223004591 Response regulator receiver domain; Region: Response_reg; pfam00072 471223004592 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 471223004593 active site 471223004594 phosphorylation site [posttranslational modification] 471223004595 intermolecular recognition site; other site 471223004596 dimerization interface [polypeptide binding]; other site 471223004597 Transposase, Mutator family; Region: Transposase_mut; pfam00872 471223004598 MULE transposase domain; Region: MULE; pfam10551 471223004599 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; cl11412 471223004600 Protein with unknown function (DUF469); Region: DUF469; cl01237 471223004601 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 471223004602 H+ Antiporter protein; Region: 2A0121; TIGR00900 471223004603 putative substrate translocation pore; other site 471223004604 D-alanine--poly(phosphoribitol) ligase subunit 1; Provisional; Region: PRK04813 471223004605 AMP-binding enzyme; Region: AMP-binding; cl15778 471223004606 Phosphopantetheine attachment site; Region: PP-binding; cl09936 471223004607 Condensation domain; Region: Condensation; pfam00668 471223004608 Transposase, Mutator family; Region: Transposase_mut; pfam00872 471223004609 MULE transposase domain; Region: MULE; pfam10551 471223004610 Mannose-1-phosphate guanylyltransferase [Cell envelope biogenesis, outer membrane]; Region: {ManC}; COG0836 471223004611 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 471223004612 active site 471223004613 Cupin domain; Region: Cupin_2; cl09118 471223004614 GDP-fucose synthetase, extended (e) SDRs; Region: GDP_FS_SDR_e; cd05239 471223004615 GDP-4-keto-6-deoxymannose-3, 5-epimerase-4-reductase; Region: PLN02725 471223004616 NADP binding site [chemical binding]; other site 471223004617 active site 471223004618 putative substrate binding site [chemical binding]; other site 471223004619 DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808 471223004620 Transposase domain (DUF772); Region: DUF772; cl15789 471223004621 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 471223004622 Transposase domain (DUF772); Region: DUF772; cl15789 471223004623 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 471223004624 Transposase domain (DUF772); Region: DUF772; cl15789 471223004625 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 471223004626 Type 1 glutamine amidotransferase (GATase1)-like domain found in peptidase E; Region: GAT1_Peptidase_E; cd03146 471223004627 active site pocket [active] 471223004628 oxyanion hole [active] 471223004629 catalytic triad [active] 471223004630 active site nucleophile [active] 471223004631 Helix-turn-helix domain of transposase family ISL3; Region: HTH_Tnp_ISL3; pfam13542 471223004632 Helix-turn-helix domains; Region: HTH; cl00088 471223004633 Integrase core domain; Region: rve; cl01316 471223004634 Integrase core domain; Region: rve_3; cl15866 471223004635 Mu transposase, C-terminal; Region: Mu-transpos_C; pfam09299 471223004636 Type II secretory pathway, component ExeA (predicted ATPase) [Intracellular trafficking and secretion]; Region: ExeA; COG3267 471223004637 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 471223004638 Walker A motif; other site 471223004639 ATP binding site [chemical binding]; other site 471223004640 Walker B motif; other site 471223004641 arginine finger; other site 471223004642 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 471223004643 nudix motif; other site 471223004644 Sigma factor regulator N-terminal; Region: Sigma_reg_N; pfam13800 471223004645 Sigma factor regulator C-terminal; Region: Sigma_reg_C; pfam13791 471223004646 Transposase, Mutator family; Region: Transposase_mut; pfam00872 471223004647 MULE transposase domain; Region: MULE; pfam10551 471223004648 Putative multicopper oxidases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: SufI; COG2132 471223004649 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; cl11412 471223004650 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; cl11412 471223004651 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; cl11412 471223004652 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 471223004653 metal-binding site [ion binding] 471223004654 Transposase; Region: DEDD_Tnp_IS110; pfam01548 471223004655 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 471223004656 Transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this domain superfamily was previously known as DUF156; Region: CsoR-like_DUF156; cl00846 471223004657 putative homotetramer interface [polypeptide binding]; other site 471223004658 putative homodimer interface [polypeptide binding]; other site 471223004659 putative allosteric switch controlling residues; other site 471223004660 putative metal binding site [ion binding]; other site 471223004661 putative homodimer-homodimer interface [polypeptide binding]; other site 471223004662 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 471223004663 Type II secretory pathway, component ExeA (predicted ATPase) [Intracellular trafficking and secretion]; Region: ExeA; COG3267 471223004664 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 471223004665 Walker A motif; other site 471223004666 ATP binding site [chemical binding]; other site 471223004667 Walker B motif; other site 471223004668 arginine finger; other site 471223004669 LysR transcriptional regulator; Provisional; Region: rbcR; CHL00180 471223004670 Helix-turn-helix domains; Region: HTH; cl00088 471223004671 C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420 471223004672 putative dimerization interface [polypeptide binding]; other site 471223004673 Conserved hypothetical protein 698; Region: Cons_hypoth698; cl01075 471223004674 gp58-like protein; Region: Gp58; pfam07902 471223004675 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 471223004676 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 471223004677 metal-binding site [ion binding] 471223004678 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 471223004679 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 471223004680 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 471223004681 dimerization interface [polypeptide binding]; other site 471223004682 putative DNA binding site [nucleotide binding]; other site 471223004683 putative Zn2+ binding site [ion binding]; other site 471223004684 RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651 471223004685 Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078 471223004686 putative active site [active] 471223004687 putative NTP binding site [chemical binding]; other site 471223004688 putative nucleic acid binding site [nucleotide binding]; other site 471223004689 Group II intron, maturase-specific domain; Region: GIIM; pfam08388 471223004690 Short C-terminal domain; Region: SHOCT; cl01373 471223004691 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 471223004692 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 471223004693 heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386 471223004694 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 471223004695 dimerization interface [polypeptide binding]; other site 471223004696 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 471223004697 dimer interface [polypeptide binding]; other site 471223004698 phosphorylation site [posttranslational modification] 471223004699 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 471223004700 metal binding site [ion binding]; metal-binding site 471223004701 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 471223004702 Transposase; Region: DDE_Tnp_ISL3; pfam01610 471223004703 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 471223004704 putative substrate translocation pore; other site 471223004705 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 471223004706 FAD binding domain; Region: FAD_binding_4; pfam01565 471223004707 short chain dehydrogenase; Provisional; Region: PRK06914 471223004708 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 471223004709 NADP binding site [chemical binding]; other site 471223004710 active site 471223004711 steroid binding site; other site 471223004712 Low molecular weight phosphatase family; Region: LMWPc; cd00115 471223004713 active site 471223004714 ABC-type molybdate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: ModA; COG0725 471223004715 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 471223004716 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 471223004717 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 471223004718 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 471223004719 dimer interface [polypeptide binding]; other site 471223004720 conserved gate region; other site 471223004721 putative PBP binding loops; other site 471223004722 ABC-ATPase subunit interface; other site 471223004723 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 471223004724 cell division ATP-binding protein FtsE; Region: FtsE; TIGR02673 471223004725 Walker A/P-loop; other site 471223004726 ATP binding site [chemical binding]; other site 471223004727 Q-loop/lid; other site 471223004728 ABC transporter signature motif; other site 471223004729 Walker B; other site 471223004730 D-loop; other site 471223004731 H-loop/switch region; other site 471223004732 amino acid transporter; Region: 2A0306; TIGR00909 471223004733 Spore germination protein; Region: Spore_permease; cl15802 471223004734 Spore germination protein; Region: Spore_permease; cl15802 471223004735 Uncharacterized conserved protein [Function unknown]; Region: COG4717 471223004736 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 471223004737 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 471223004738 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 471223004739 motif II; other site 471223004740 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 471223004741 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 471223004742 Walker A/P-loop; other site 471223004743 ATP binding site [chemical binding]; other site 471223004744 Q-loop/lid; other site 471223004745 ABC transporter signature motif; other site 471223004746 Walker B; other site 471223004747 D-loop; other site 471223004748 H-loop/switch region; other site 471223004749 lipoyltransferase and lipoate-protein ligase; Region: lipoyltrans; TIGR00545 471223004750 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 471223004751 Bacterial lipoate protein ligase C-terminus; Region: Lip_prot_lig_C; pfam10437 471223004752 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 471223004753 transposase, putative, N-terminal domain; Region: tspaseT_teng_N; TIGR01765 471223004754 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 471223004755 Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282 471223004756 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 471223004757 Transposase; Region: DDE_Tnp_ISL3; pfam01610 471223004758 hybrid cluster protein; Provisional; Region: PRK05290 471223004759 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 471223004760 Lysine 2,3-aminomutase [Amino acid transport and metabolism]; Region: KamA; COG1509 471223004761 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cl15377 471223004762 Predicted membrane protein [Function unknown]; Region: COG3428 471223004763 Bacterial PH domain; Region: DUF304; cl01348 471223004764 Bacterial PH domain; Region: DUF304; cl01348 471223004765 Bacterial PH domain; Region: DUF304; cl01348 471223004766 Bacterial PH domain; Region: DUF304; cl01348 471223004767 Predicted membrane protein [Function unknown]; Region: COG1511 471223004768 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 471223004769 ABC-2 type transporter; Region: ABC2_membrane; cl11417 471223004770 QueT transporter; Region: QueT; cl01932 471223004771 Transposase, Mutator family; Region: Transposase_mut; pfam00872 471223004772 MULE transposase domain; Region: MULE; pfam10551 471223004773 DNA polymerase IV; Validated; Region: PRK01810 471223004774 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 471223004775 active site 471223004776 DNA binding site [nucleotide binding] 471223004777 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 471223004778 transposase, putative, N-terminal domain; Region: tspaseT_teng_N; TIGR01765 471223004779 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 471223004780 Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282 471223004781 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 471223004782 Domain of unknown function DUF21; Region: DUF21; pfam01595 471223004783 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 471223004784 Transporter associated domain; Region: CorC_HlyC; cl08393 471223004785 Putative neutral zinc metallopeptidase; Region: Zn_peptidase_2; cl01049 471223004786 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 471223004787 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 471223004788 DNA binding residues [nucleotide binding] 471223004789 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 471223004790 Helix-turn-helix domains; Region: HTH; cl00088 471223004791 YsiA-like protein, C-terminal region; Region: TetR_C_4; pfam08359 471223004792 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 471223004793 SAV4209_like. Similar in sequence to the Streptomyces avermitilis SAV4209 protein, with a hot dog fold that is similar to those of (R)-specific enoyl-CoA hydratase, the peroxisomal Hydratase-Dehydrogenase-Epimerase (HDE) protein, and the fatty acid...; Region: SAV4209_like; cd03453 471223004794 active site 471223004795 catalytic site [active] 471223004796 (R)-hydratase [(R)-specific enoyl-CoA hydratase]. Catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. The structure of the monomer includes a five-strand antiparallel...; Region: R_hydratase_like; cd03441 471223004797 active site 471223004798 catalytic site [active] 471223004799 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 471223004800 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 471223004801 NAD(P) binding site [chemical binding]; other site 471223004802 homotetramer interface [polypeptide binding]; other site 471223004803 homodimer interface [polypeptide binding]; other site 471223004804 active site 471223004805 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 471223004806 NAD-dependent deacetylase; Provisional; Region: PRK00481 471223004807 SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2; cl00195 471223004808 arginine/ornithine antiporter; Region: arg_ornith_anti; TIGR03810 471223004809 Spore germination protein; Region: Spore_permease; cl15802 471223004810 HAD superfamily (subfamily IA) hydrolase, TIGR02253; Region: CTE7 471223004811 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 471223004812 motif II; other site 471223004813 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 471223004814 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 471223004815 Coenzyme A binding pocket [chemical binding]; other site 471223004816 Domain of Unknown Function (DUF350); Region: DUF350; pfam03994 471223004817 A circularly permuted ATPgrasp; Region: CP_ATPgrasp_1; cl00503 471223004818 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 471223004819 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 471223004820 Transposase DDE domain group 1; Region: DDE_Tnp_1_4; pfam13701 471223004821 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 471223004822 Transposase; Region: DDE_Tnp_ISL3; pfam01610 471223004823 cxxc_20_cxxc protein; Region: cxxc_20_cxxc; TIGR04104 471223004824 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 471223004825 metal-binding site [ion binding] 471223004826 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 471223004827 metal-binding site [ion binding] 471223004828 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 471223004829 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 471223004830 metal-binding site [ion binding] 471223004831 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 471223004832 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 471223004833 motif II; other site 471223004834 Transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this domain superfamily was previously known as DUF156; Region: CsoR-like_DUF156; cl00846 471223004835 putative homotetramer interface [polypeptide binding]; other site 471223004836 putative homodimer interface [polypeptide binding]; other site 471223004837 putative allosteric switch controlling residues; other site 471223004838 putative metal binding site [ion binding]; other site 471223004839 putative homodimer-homodimer interface [polypeptide binding]; other site 471223004840 aminoglycoside resistance protein; Provisional; Region: PRK13746 471223004841 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 471223004842 active site 471223004843 NTP binding site [chemical binding]; other site 471223004844 metal binding triad [ion binding]; metal-binding site 471223004845 Domain of unknown function (DUF4111); Region: DUF4111; pfam13427 471223004846 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 471223004847 putative substrate translocation pore; other site 471223004848 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; cl14891 471223004849 Integrase core domain; Region: rve; cl01316 471223004850 Transposase domain (DUF772); Region: DUF772; cl15789 471223004851 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 471223004852 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 471223004853 Probable transposase; Region: OrfB_IS605; pfam01385 471223004854 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 471223004855 Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282 471223004856 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 471223004857 ABC-2 type transporter; Region: ABC2_membrane; cl11417 471223004858 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 471223004859 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 471223004860 Walker A/P-loop; other site 471223004861 ATP binding site [chemical binding]; other site 471223004862 Q-loop/lid; other site 471223004863 ABC transporter signature motif; other site 471223004864 Walker B; other site 471223004865 D-loop; other site 471223004866 H-loop/switch region; other site 471223004867 Members of the SGNH-hydrolase superfamily, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_YpmR_like; cd04506 471223004868 active site 471223004869 catalytic triad [active] 471223004870 oxyanion hole [active] 471223004871 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 471223004872 Predicted permeases [General function prediction only]; Region: COG0730; cl00498 471223004873 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 471223004874 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 471223004875 putative active site pocket [active] 471223004876 dimerization interface [polypeptide binding]; other site 471223004877 putative catalytic residue [active] 471223004878 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box protein; Region: CSP_CDS; cd04458 471223004879 DNA-binding site [nucleotide binding]; DNA binding site 471223004880 RNA-binding motif; other site 471223004881 Peroxiredoxin (PRX)-like 1 family; hypothetical proteins that show sequence similarity to PRXs. Members of this group contain a conserved cysteine that aligns to the first cysteine in the CXXC motif of TRX. This does not correspond to the peroxidatic...; Region: PRX_like1; cd02969 471223004882 putative catalytic residue [active] 471223004883 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 471223004884 Probable transposase; Region: OrfB_IS605; pfam01385 471223004885 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 471223004886 Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282 471223004887 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 471223004888 dimerization interface [polypeptide binding]; other site 471223004889 putative DNA binding site [nucleotide binding]; other site 471223004890 putative Zn2+ binding site [ion binding]; other site 471223004891 ABC-2 type transporter; Region: ABC2_membrane; cl11417 471223004892 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 471223004893 This family of ATP-binding proteins belongs to a multisubunit transporter involved in drug resistance (BcrA and DrrA), nodulation, lipid transport, and lantibiotic immunity. In bacteria and archaea, these transporters usually include an ATP-binding...; Region: ABC_DR_subfamily_A; cd03230 471223004894 Walker A/P-loop; other site 471223004895 ATP binding site [chemical binding]; other site 471223004896 Q-loop/lid; other site 471223004897 ABC transporter signature motif; other site 471223004898 Walker B; other site 471223004899 D-loop; other site 471223004900 H-loop/switch region; other site 471223004901 Predicted transcriptional regulators [Transcription]; Region: COG1725 471223004902 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 471223004903 DNA-binding site [nucleotide binding]; DNA binding site 471223004904 Protein of unknown function (DUF421); Region: DUF421; cl00990 471223004905 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 471223004906 dimer interface [polypeptide binding]; other site 471223004907 phosphorylation site [posttranslational modification] 471223004908 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 471223004909 ATP binding site [chemical binding]; other site 471223004910 Mg2+ binding site [ion binding]; other site 471223004911 G-X-G motif; other site 471223004912 EamA-like transporter family; Region: EamA; cl01037 471223004913 EamA-like transporter family; Region: EamA; cl01037 471223004914 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 471223004915 EamA-like transporter family; Region: EamA; cl01037 471223004916 Uncharacterized protein family (UPF0236); Region: UPF0236; pfam06782 471223004917 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 471223004918 Major Facilitator Superfamily; Region: MFS_1; pfam07690 471223004919 putative substrate translocation pore; other site 471223004920 Membrane carboxypeptidase (penicillin-binding protein) [Cell envelope biogenesis, outer membrane]; Region: MrcB; COG0744 471223004921 Transglycosylase; Region: Transgly; cl07896 471223004922 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 471223004923 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 471223004924 putative substrate translocation pore; other site 471223004925 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 471223004926 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 471223004927 Helix-turn-helix domains; Region: HTH; cl00088 471223004928 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 471223004929 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl15772 471223004930 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl15772 471223004931 enoyl-CoA hydratase; Provisional; Region: PRK07657 471223004932 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 471223004933 substrate binding site [chemical binding]; other site 471223004934 oxyanion hole (OAH) forming residues; other site 471223004935 trimer interface [polypeptide binding]; other site 471223004936 3-hydroxy-3-methylglutaryl-CoA lyase, catalytic TIM barrel domain; Region: DRE_TIM_HMGL; cd07938 471223004937 active site 471223004938 catalytic residues [active] 471223004939 metal binding site [ion binding]; metal-binding site 471223004940 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 471223004941 carboxyltransferase (CT) interaction site; other site 471223004942 biotinylation site [posttranslational modification]; other site 471223004943 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK06111 471223004944 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 471223004945 ATP-grasp domain; Region: ATP-grasp_4; cl03087 471223004946 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; cl08365 471223004947 Transposase domain (DUF772); Region: DUF772; cl15789 471223004948 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 471223004949 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 471223004950 Short chain acyl-CoA dehydrogenases and eukaryotic short/branched chain acyl-CoA dehydrogenases; Region: SCAD_SBCAD; cd01158 471223004951 FAD binding site [chemical binding]; other site 471223004952 homotetramer interface [polypeptide binding]; other site 471223004953 substrate binding pocket [chemical binding]; other site 471223004954 catalytic base [active] 471223004955 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 471223004956 Helix-turn-helix domains; Region: HTH; cl00088 471223004957 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 471223004958 Predicted acetyltransferase [General function prediction only]; Region: COG3393 471223004959 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 471223004960 DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808 471223004961 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 471223004962 transposase, putative, N-terminal domain; Region: tspaseT_teng_N; TIGR01765 471223004963 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 471223004964 Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282 471223004965 threonine dehydratase; Provisional; Region: PRK08198 471223004966 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 471223004967 tetramer interface [polypeptide binding]; other site 471223004968 pyridoxal 5'-phosphate binding site [chemical binding]; other site 471223004969 catalytic residue [active] 471223004970 C-terminal ACT domain of biodegradative (catabolic) threonine dehydratase II (ThrD-II) and other related ACT domains; Region: ACT_ThrD-II-like; cd04886 471223004971 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 471223004972 Major Facilitator Superfamily; Region: MFS_1; pfam07690 471223004973 putative substrate translocation pore; other site 471223004974 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 471223004975 transposase, putative, N-terminal domain; Region: tspaseT_teng_N; TIGR01765 471223004976 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 471223004977 Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282 471223004978 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 471223004979 active site 471223004980 multidrug efflux protein; Reviewed; Region: PRK01766 471223004981 MatE; Region: MatE; cl10513 471223004982 MatE; Region: MatE; cl10513 471223004983 Predicted permeases [General function prediction only]; Region: RarD; COG2962 471223004984 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 471223004985 Cation efflux family; Region: Cation_efflux; cl00316 471223004986 D-ala-D-ala dipeptidase; Region: Peptidase_M15; cl00813 471223004987 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 471223004988 Uridine phosphorylase [Nucleotide transport and metabolism]; Region: Udp; COG2820 471223004989 Transposase; Region: DEDD_Tnp_IS110; pfam01548 471223004990 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 471223004991 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 471223004992 Probable transposase; Region: OrfB_IS605; pfam01385 471223004993 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 471223004994 Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282 471223004995 YozD-like protein; Region: YozD; pfam14162 471223004996 Protein of unknown function (DUF1250); Region: DUF1250; cl11485 471223004997 biotin synthase; Validated; Region: PRK06256 471223004998 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 471223004999 FeS/SAM binding site; other site 471223005000 Biotin and Thiamin Synthesis associated domain; Region: BATS; cl06149 471223005001 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 471223005002 binding surface 471223005003 TPR motif; other site 471223005004 Tetratrico peptide repeat; Region: TPR_5; pfam12688 471223005005 Uncharacterized FAD-dependent dehydrogenases [General function prediction only]; Region: COG2509 471223005006 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 471223005007 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 471223005008 Protein of unknown function (DUF502); Region: DUF502; cl01107 471223005009 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 471223005010 magnesium/nickel/cobalt transporter CorA; Provisional; Region: PRK11085; cl00459 471223005011 Iron-sulphur cluster biosynthesis; Region: Fe-S_biosyn; cl00400 471223005012 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 471223005013 CoenzymeA binding site [chemical binding]; other site 471223005014 subunit interaction site [polypeptide binding]; other site 471223005015 PHB binding site; other site 471223005016 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 471223005017 active site 471223005018 small acid-soluble spore protein Tlp; Provisional; Region: PRK03830; cl07951 471223005019 Small acid-soluble spore protein N family; Region: SspN; cl11659 471223005020 Protein of unknown function (DUF3901); Region: DUF3901; pfam13040 471223005021 Uncharacterized protein SCO1/SenC/PrrC, involved in biogenesis of respiratory and photosynthetic systems [General function prediction only]; Region: COG1999 471223005022 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 471223005023 catalytic residues [active] 471223005024 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 471223005025 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 471223005026 active site residue [active] 471223005027 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 471223005028 active site residue [active] 471223005029 Protein of unknown function (DUF2533); Region: DUF2533; pfam10752 471223005030 Predicted nucleotidyltransferase; Region: Nuc-transf; cl01417 471223005031 Dynamin-like protein including dynamins, mitofusins, and guanylate-binding proteins; Region: DLP_2; cd09912 471223005032 Dynamin family; Region: Dynamin_N; pfam00350 471223005033 G1 box; other site 471223005034 GTP/Mg2+ binding site [chemical binding]; other site 471223005035 G2 box; other site 471223005036 Switch I region; other site 471223005037 G3 box; other site 471223005038 Switch II region; other site 471223005039 G4 box; other site 471223005040 G5 box; other site 471223005041 Predicted GTPases [General function prediction only]; Region: COG1161 471223005042 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 471223005043 Dynamin family; Region: Dynamin_N; pfam00350 471223005044 G1 box; other site 471223005045 GTP/Mg2+ binding site [chemical binding]; other site 471223005046 G2 box; other site 471223005047 Switch I region; other site 471223005048 Dynamin-like protein including dynamins, mitofusins, and guanylate-binding proteins; Region: DLP_2; cd09912 471223005049 G3 box; other site 471223005050 Switch II region; other site 471223005051 GTP/Mg2+ binding site [chemical binding]; other site 471223005052 G4 box; other site 471223005053 G5 box; other site 471223005054 Heme/copper-type cytochrome/quinol oxidases, subunit 2 [Energy production and conversion]; Region: CyoA; COG1622 471223005055 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; cl11412 471223005056 Heme-copper oxidase subunit I. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which catalyze the reduction of O2 and simultaneously pump protons across the membrane. The superfamily is...; Region: Heme_Cu_Oxidase_I; cl00275 471223005057 D-pathway; other site 471223005058 Low-spin heme binding site [chemical binding]; other site 471223005059 Putative water exit pathway; other site 471223005060 Binuclear center (active site) [active] 471223005061 K-pathway; other site 471223005062 Putative proton exit pathway; other site 471223005063 Zn-dependent carboxypeptidase [Amino acid transport and metabolism]; Region: COG2317 471223005064 Peptidase family M32 includes thermostable carboxypeptidases TaqCP and PfuCP; Region: M32_Taq; cd06460 471223005065 active site 471223005066 Zn binding site [ion binding]; other site 471223005067 Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199 471223005068 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 471223005069 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 471223005070 Predicted N6-adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0116 471223005071 THUMP domain; Region: THUMP; cl12076 471223005072 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 471223005073 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 471223005074 PAS domain; Region: PAS_9; pfam13426 471223005075 putative active site [active] 471223005076 heme pocket [chemical binding]; other site 471223005077 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 471223005078 metal binding site [ion binding]; metal-binding site 471223005079 active site 471223005080 I-site; other site 471223005081 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 471223005082 cell division protein GpsB; Provisional; Region: PRK14127 471223005083 DivIVA domain; Region: DivI1A_domain; TIGR03544 471223005084 Protein of unknown function (DUF1273); Region: DUF1273; cl01859 471223005085 Inner spore coat protein D; Region: Spore-coat_CotD; pfam11122 471223005086 Predicted exonuclease [DNA replication, recombination, and repair]; Region: COG3359 471223005087 DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012 471223005088 active site 471223005089 substrate binding site [chemical binding]; other site 471223005090 Predicted N-acetylglucosaminyl transferase [Carbohydrate transport and metabolism]; Region: COG2956 471223005091 Distinct helicase family with a unique C-terminal domain including a metal-binding cysteine cluster [General function prediction only]; Region: COG1205 471223005092 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 471223005093 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 471223005094 ATP binding site [chemical binding]; other site 471223005095 putative Mg++ binding site [ion binding]; other site 471223005096 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 471223005097 nucleotide binding region [chemical binding]; other site 471223005098 ATP-binding site [chemical binding]; other site 471223005099 Domain of unknown function (DUF1998); Region: DUF1998; pfam09369 471223005100 Transcriptional regulator [Transcription]; Region: IclR; COG1414 471223005101 Helix-turn-helix domains; Region: HTH; cl00088 471223005102 Bacterial transcriptional regulator; Region: IclR; pfam01614 471223005103 Malic enzyme [Energy production and conversion]; Region: SfcA; COG0281 471223005104 Malic enzyme, N-terminal domain; Region: malic; pfam00390 471223005105 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 471223005106 putative NAD(P) binding site [chemical binding]; other site 471223005107 Malate synthase G (MSG), monomeric enzyme present in some bacteria. In general, malate synthase catalyzes the Claisen condensation of glyoxylate and acetyl-CoA to malyl-CoA , which hydrolyzes to malate and CoA. This reaction is part of the glyoxylate...; Region: malate_synt_G; cd00728 471223005108 active site 471223005109 FAD binding domain; Region: FAD_binding_4; pfam01565 471223005110 glycolate oxidase, subunit GlcD; Region: glcD; TIGR00387 471223005111 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 471223005112 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 471223005113 Cysteine-rich domain; Region: CCG; pfam02754 471223005114 Cysteine-rich domain; Region: CCG; pfam02754 471223005115 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 471223005116 FAD binding domain; Region: FAD_binding_4; pfam01565 471223005117 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 471223005118 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 471223005119 hydroxypyruvate isomerase; Region: OH-pyruv-isom; TIGR03234 471223005120 Transposase DDE domain group 1; Region: DDE_Tnp_1_4; pfam13701 471223005121 Bacterial BAX inhibitor (BI)-1/YccA-like proteins; Region: BI-1-like_bacterial; cd10432 471223005122 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 471223005123 transposase, putative, N-terminal domain; Region: tspaseT_teng_N; TIGR01765 471223005124 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 471223005125 Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282 471223005126 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 471223005127 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 471223005128 dimer interface [polypeptide binding]; other site 471223005129 pyridoxal 5'-phosphate binding site [chemical binding]; other site 471223005130 catalytic residue [active] 471223005131 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 471223005132 dimerization interface [polypeptide binding]; other site 471223005133 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 471223005134 dimer interface [polypeptide binding]; other site 471223005135 phosphorylation site [posttranslational modification] 471223005136 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 471223005137 ATP binding site [chemical binding]; other site 471223005138 Mg2+ binding site [ion binding]; other site 471223005139 G-X-G motif; other site 471223005140 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 471223005141 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 471223005142 active site 471223005143 phosphorylation site [posttranslational modification] 471223005144 intermolecular recognition site; other site 471223005145 dimerization interface [polypeptide binding]; other site 471223005146 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 471223005147 DNA binding site [nucleotide binding] 471223005148 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 471223005149 structural tetrad; other site 471223005150 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 471223005151 putative substrate translocation pore; other site 471223005152 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cl11420 471223005153 Peptidase S8 family domain in Thermitase-like proteins; Region: Peptidases_S8_Thermitase_like; cd07484 471223005154 active site 471223005155 catalytic triad [active] 471223005156 Uncharacterized protein family (UPF0236); Region: UPF0236; pfam06782 471223005157 lysine transporter; Provisional; Region: PRK10836 471223005158 Spore germination protein; Region: Spore_permease; cl15802 471223005159 mttA/Hcf106 family; Region: MttA_Hcf106; cl00788 471223005160 Small acid-soluble spore protein H family; Region: SspH; cl06949 471223005161 OpgC protein; Region: OpgC_C; cl00792 471223005162 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 471223005163 thiamine phosphate binding site [chemical binding]; other site 471223005164 active site 471223005165 pyrophosphate binding site [ion binding]; other site 471223005166 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 471223005167 dimer interface [polypeptide binding]; other site 471223005168 substrate binding site [chemical binding]; other site 471223005169 ATP binding site [chemical binding]; other site 471223005170 4-methyl-5-beta-hydroxyethylthiazole (Thz) kinase catalyzes the phosphorylation of the hydroxylgroup of Thz. A reaction that allows cells to recycle Thz into the thiamine biosynthesis pathway, as an alternative to its synthesis from cysteine, tyrosine...; Region: THZ_kinase; cd01170 471223005171 substrate binding site [chemical binding]; other site 471223005172 multimerization interface [polypeptide binding]; other site 471223005173 ATP binding site [chemical binding]; other site 471223005174 DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808 471223005175 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 471223005176 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 471223005177 Ligand binding site; other site 471223005178 Putative Catalytic site; other site 471223005179 DXD motif; other site 471223005180 Predicted membrane protein (DUF2079); Region: DUF2079; pfam09852 471223005181 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK08314 471223005182 AMP-binding enzyme; Region: AMP-binding; cl15778 471223005183 AMP-binding enzyme; Region: AMP-binding; cl15778 471223005184 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 471223005185 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 471223005186 motif II; other site 471223005187 Predicted acetyltransferase [General function prediction only]; Region: COG3393 471223005188 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 471223005189 LysE type translocator; Region: LysE; cl00565 471223005190 LamB/YcsF family; Region: LamB_YcsF; cl00664 471223005191 Allophanate hydrolase subunit 2; Region: AHS2; cl00865 471223005192 Allophanate hydrolase subunit 1; Region: AHS1; pfam02682 471223005193 Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; cl00896 471223005194 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 471223005195 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 471223005196 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 471223005197 DNA-binding site [nucleotide binding]; DNA binding site 471223005198 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 471223005199 pyridoxal 5'-phosphate binding site [chemical binding]; other site 471223005200 homodimer interface [polypeptide binding]; other site 471223005201 catalytic residue [active] 471223005202 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 471223005203 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl15357 471223005204 transmembrane helices; other site 471223005205 putative carbohydrate kinase; Provisional; Region: PRK10565 471223005206 YjeF-related protein N-terminus; Region: YjeF_N; cl00318 471223005207 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 471223005208 putative substrate binding site [chemical binding]; other site 471223005209 putative ATP binding site [chemical binding]; other site 471223005210 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 471223005211 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 471223005212 putative substrate translocation pore; other site 471223005213 Protein of unknown function, DUF393; Region: DUF393; cl01136 471223005214 Uncharacterized ACR, COG2135; Region: DUF159; cl03646 471223005215 Uncharacterized conserved protein (DUF2294); Region: DUF2294; cl02390 471223005216 DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808 471223005217 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 471223005218 Probable transposase; Region: OrfB_IS605; pfam01385 471223005219 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 471223005220 Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282 471223005221 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 471223005222 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 471223005223 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 471223005224 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 471223005225 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl15357 471223005226 ABC-2 family transporter protein; Region: ABC2_membrane_6; cl01496 471223005227 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4587 471223005228 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4587 471223005229 ABC-2 family transporter protein; Region: ABC2_membrane_6; cl01496 471223005230 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4586 471223005231 Similar in sequence to NatA, this is the ATPase component of a bacterial ABC-type Na+ transport system called NatAB, which catalyzes ATP-dependent electrogenic Na+ extrusion without mechanically coupled to proton or K+ uptake. NatB possess six putative...; Region: ABC_NatA_like; cd03267 471223005232 Walker A/P-loop; other site 471223005233 ATP binding site [chemical binding]; other site 471223005234 Q-loop/lid; other site 471223005235 ABC transporter signature motif; other site 471223005236 Walker B; other site 471223005237 D-loop; other site 471223005238 H-loop/switch region; other site 471223005239 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 471223005240 ABC-ATPase subunit interface; other site 471223005241 dimer interface [polypeptide binding]; other site 471223005242 putative PBP binding regions; other site 471223005243 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 471223005244 ABC-ATPase subunit interface; other site 471223005245 dimer interface [polypeptide binding]; other site 471223005246 putative PBP binding regions; other site 471223005247 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 471223005248 Periplasmic binding protein FeuA. These proteins have predicted to function as initial receptors in ABC transport of metal ions in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct...; Region: FeuA; cd01138 471223005249 putative ligand binding residues [chemical binding]; other site 471223005250 acetoacetyl-CoA synthetase; Provisional; Region: PRK03584 471223005251 Domain of unknown function (DUF3448); Region: DUF3448; pfam11930 471223005252 AMP-binding enzyme; Region: AMP-binding; cl15778 471223005253 FeoA domain; Region: FeoA; cl00838 471223005254 Ferrous iron transport protein B; Region: FeoB_N; pfam02421 471223005255 Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879 471223005256 G1 box; other site 471223005257 GTP/Mg2+ binding site [chemical binding]; other site 471223005258 Switch I region; other site 471223005259 G2 box; other site 471223005260 G3 box; other site 471223005261 Switch II region; other site 471223005262 G4 box; other site 471223005263 G5 box; other site 471223005264 Nucleoside recognition; Region: Gate; cl00486 471223005265 Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664 471223005266 Nucleoside recognition; Region: Gate; cl00486 471223005267 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 471223005268 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 471223005269 catalytic core [active] 471223005270 Microcin C7 self-immunity protein determines resistance to exogenous microcin C7; Region: Peptidase_S66_mccF_like; cd07062 471223005271 putative dimer interface [polypeptide binding]; other site 471223005272 catalytic triad [active] 471223005273 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 471223005274 catalytic core [active] 471223005275 Aminoglycoside 3-N-acetyltransferase; Region: Antibiotic_NAT; cl01051 471223005276 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 471223005277 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 471223005278 Coenzyme A binding pocket [chemical binding]; other site 471223005279 Bacterial membrane-spanning protein N-terminus; Region: YojJ; pfam10372 471223005280 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 471223005281 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 471223005282 PAS domain; Region: PAS_9; pfam13426 471223005283 putative active site [active] 471223005284 heme pocket [chemical binding]; other site 471223005285 hypothetical protein; Provisional; Region: PRK13560 471223005286 Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain); Region: PAC; smart00086 471223005287 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 471223005288 metal binding site [ion binding]; metal-binding site 471223005289 active site 471223005290 I-site; other site 471223005291 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 471223005292 Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276 471223005293 FhuF 2Fe-2S C-terminal domain; Region: FhuF_C; pfam11575 471223005294 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 471223005295 ABC transporters, involved in the uptake of siderophores, heme, and vitamin B12, are widely conserved in bacteria and archaea. Only very few species lack representatives of the siderophore family transporters. The E. coli BtuCD protein is an ABC...; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 471223005296 Walker A/P-loop; other site 471223005297 ATP binding site [chemical binding]; other site 471223005298 Q-loop/lid; other site 471223005299 ABC transporter signature motif; other site 471223005300 Walker B; other site 471223005301 D-loop; other site 471223005302 H-loop/switch region; other site 471223005303 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 471223005304 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 471223005305 ABC-ATPase subunit interface; other site 471223005306 dimer interface [polypeptide binding]; other site 471223005307 putative PBP binding regions; other site 471223005308 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 471223005309 ABC-ATPase subunit interface; other site 471223005310 dimer interface [polypeptide binding]; other site 471223005311 putative PBP binding regions; other site 471223005312 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 471223005313 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 471223005314 siderophore binding site; other site 471223005315 Protein of unknown function with PCYCGC motif; Region: PCYCGC; pfam13798 471223005316 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 471223005317 Protein of unknown function (DUF4025); Region: DUF4025; pfam13217 471223005318 Protein of unknown function (DUF2512); Region: DUF2512; pfam10710 471223005319 Toxic anion resistance protein (TelA); Region: TelA; pfam05816 471223005320 5-bromo-4-chloroindolyl phosphate hydrolysis protein; Region: Halogen_Hydrol; cl02059 471223005321 Protein of unknown function (DUF541); Region: SIMPL; cl01077 471223005322 Predicted membrane protein [Function unknown]; Region: COG4640 471223005323 Major Facilitator Superfamily; Region: MFS_1; pfam07690 471223005324 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 471223005325 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 471223005326 Helix-turn-helix domain of transposase family ISL3; Region: HTH_Tnp_ISL3; pfam13542 471223005327 Type II secretory pathway, component ExeA (predicted ATPase) [Intracellular trafficking and secretion]; Region: ExeA; COG3267 471223005328 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 471223005329 Walker A motif; other site 471223005330 ATP binding site [chemical binding]; other site 471223005331 Walker B motif; other site 471223005332 arginine finger; other site 471223005333 CRISPR/Cas system-associated protein Cas2; Region: Cas2_I_II_III; cd09725 471223005334 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641 471223005335 CRISPR/Cas system-associated protein Cas3''; Region: Cas3''_I; cd09641 471223005336 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 471223005337 CRISPR-associated helicase Cas3; Region: cas3_core; TIGR01587 471223005338 CRISPR-associated protein Cas5, subtype I-B/TNEAP; Region: cas_Cas5t; TIGR01895 471223005339 CRISPR/Cas system-associated RAMP superfamily protein Cas5; Region: Cas5_I; cl12040 471223005340 CRISPR/Cas system-associated RAMP superfamily protein Cas7; Region: Cas7_I; cl00803 471223005341 CRISPR/Cas system-associated protein Cas8a1; Region: Cas8a1_I-A; cl09909 471223005342 CRISPR/Cas system-associated RAMP superfamily protein Cas6; Region: Cas6-I-III; cd09652 471223005343 Transposase domain (DUF772); Region: DUF772; cl15789 471223005344 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 471223005345 putative acyltransferase; Provisional; Region: PRK05790 471223005346 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 471223005347 dimer interface [polypeptide binding]; other site 471223005348 active site 471223005349 6-phosphogluconate dehydratase; Region: edd; TIGR01196 471223005350 Dehydratase family; Region: ILVD_EDD; cl00340 471223005351 VanZ like family; Region: VanZ; cl01971 471223005352 gamma-glutamyl kinase; Provisional; Region: PRK05429 471223005353 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 471223005354 nucleotide binding site [chemical binding]; other site 471223005355 homotetrameric interface [polypeptide binding]; other site 471223005356 putative phosphate binding site [ion binding]; other site 471223005357 putative allosteric binding site; other site 471223005358 PUA domain; Region: PUA; cl00607 471223005359 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 471223005360 gamma-glutamyl phosphate reductase; Region: proA; TIGR00407 471223005361 putative catalytic cysteine [active] 471223005362 Domain of unknown function (DUF3784); Region: DUF3784; pfam12650 471223005363 GtrA-like protein; Region: GtrA; cl00971 471223005364 Exonuclease VII, large subunit; Region: Exonuc_VII_L; pfam02601 471223005365 shikimate kinase; Reviewed; Region: aroK; PRK00131 471223005366 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 471223005367 ADP binding site [chemical binding]; other site 471223005368 magnesium binding site [ion binding]; other site 471223005369 putative shikimate binding site; other site 471223005370 Type I 3-dehydroquinase, (3-dehydroquinate dehydratase or DHQase); Region: DHQase_I; cd00502 471223005371 3-dehydroquinate dehydratase, type I; Region: aroD; TIGR01093 471223005372 active site 471223005373 catalytic residue [active] 471223005374 dimer interface [polypeptide binding]; other site 471223005375 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 471223005376 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 471223005377 active site 471223005378 motif I; other site 471223005379 motif II; other site 471223005380 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 471223005381 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 471223005382 active site 471223005383 NTP binding site [chemical binding]; other site 471223005384 metal binding triad [ion binding]; metal-binding site 471223005385 Nucleotidyltransferase substrate binding protein like; Region: NTase_sub_bind; cl08495 471223005386 Plasmid pRiA4b ORF-3-like protein; Region: PRiA4_ORF3; pfam07929 471223005387 Domain of unknown function (DUF4275); Region: DUF4275; pfam14101 471223005388 type IV pilus biogenesis/stability protein PilW; Region: type_IV_pilW; TIGR02521 471223005389 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 471223005390 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 471223005391 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 471223005392 metal binding site [ion binding]; metal-binding site 471223005393 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 471223005394 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 471223005395 DNA-directed RNA polymerase, sigma subunit (sigma70/sigma32) [Transcription]; Region: RpoD; COG0568 471223005396 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 471223005397 DNA binding residues [nucleotide binding] 471223005398 Domain of unknown function (DUF1998); Region: DUF1998; pfam09369 471223005399 Distinct helicase family with a unique C-terminal domain including a metal-binding cysteine cluster [General function prediction only]; Region: COG1205 471223005400 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 471223005401 N-terminal putative catalytic domain of uncharacterized prokaryotic and archeal HKD family nucleases fused to a DEAD/DEAH box helicase domain; Region: PLDc_N_DEXD_b3; cd09205 471223005402 PLD-like domain; Region: PLDc_2; pfam13091 471223005403 putative homodimer interface [polypeptide binding]; other site 471223005404 putative active site [active] 471223005405 catalytic site [active] 471223005406 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 471223005407 ATP binding site [chemical binding]; other site 471223005408 putative Mg++ binding site [ion binding]; other site 471223005409 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 471223005410 nucleotide binding region [chemical binding]; other site 471223005411 ATP-binding site [chemical binding]; other site 471223005412 Uncharacterized conserved protein [Function unknown]; Region: COG4997 471223005413 Transposase IS200 like; Region: Y1_Tnp; cl00848 471223005414 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 471223005415 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 471223005416 Probable transposase; Region: OrfB_IS605; pfam01385 471223005417 Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282 471223005418 Glutaminase; Region: Glutaminase; cl00907 471223005419 7-keto-8-aminopelargonate synthetase and related enzymes [Coenzyme metabolism]; Region: BioF; COG0156 471223005420 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454 471223005421 substrate-cofactor binding pocket; other site 471223005422 pyridoxal 5'-phosphate binding site [chemical binding]; other site 471223005423 catalytic residue [active] 471223005424 Transposase; Region: DEDD_Tnp_IS110; pfam01548 471223005425 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 471223005426 Spore coat assembly protein [Cell envelope biogenesis, outer membrane]; Region: CotH; COG5337 471223005427 Protein of unknown function (DUF1407); Region: DUF1407; pfam07191 471223005428 Integrase core domain; Region: rve; cl01316 471223005429 DDE domain; Region: DDE_Tnp_IS240; pfam13610 471223005430 Integrase core domain; Region: rve_3; cl15866 471223005431 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 471223005432 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_9; cd07245 471223005433 dimer interface [polypeptide binding]; other site 471223005434 putative metal binding site [ion binding]; other site 471223005435 Putative membrane peptidase family (DUF2324); Region: DUF2324; cl01810 471223005436 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 471223005437 metal binding site [ion binding]; metal-binding site 471223005438 Transposase domain (DUF772); Region: DUF772; cl15789 471223005439 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 471223005440 DoxX; Region: DoxX; cl00976 471223005441 Helix-turn-helix domains; Region: HTH; cl00088 471223005442 5'-3' exonuclease; Region: 53EXOc; smart00475 471223005443 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 471223005444 active site 471223005445 metal binding site 1 [ion binding]; metal-binding site 471223005446 putative 5' ssDNA interaction site; other site 471223005447 metal binding site 3; metal-binding site 471223005448 metal binding site 2 [ion binding]; metal-binding site 471223005449 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 471223005450 putative DNA binding site [nucleotide binding]; other site 471223005451 putative metal binding site [ion binding]; other site 471223005452 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 471223005453 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 471223005454 Transposase domain (DUF772); Region: DUF772; cl15789 471223005455 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 471223005456 Thermophilic metalloprotease (M29); Region: Peptidase_M29; pfam02073 471223005457 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 471223005458 ATP binding site [chemical binding]; other site 471223005459 putative Mg++ binding site [ion binding]; other site 471223005460 Prominin; Region: Prominin; pfam05478 471223005461 Adenine specific DNA methylase Mod [DNA replication, recombination, and repair]; Region: COG2189 471223005462 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 471223005463 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 471223005464 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 471223005465 ATP binding site [chemical binding]; other site 471223005466 putative Mg++ binding site [ion binding]; other site 471223005467 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 471223005468 nucleotide binding region [chemical binding]; other site 471223005469 ATP-binding site [chemical binding]; other site 471223005470 Transposase domain (DUF772); Region: DUF772; cl15789 471223005471 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 471223005472 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 471223005473 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 471223005474 putative dimer interface [polypeptide binding]; other site 471223005475 DNA-binding transcriptional repressor EbgR; Provisional; Region: PRK10339 471223005476 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 471223005477 DNA binding site [nucleotide binding] 471223005478 Ligand-binding domain of DNA transcription repressor GalR which is one of two regulatory proteins involved in galactose transport and metabolism; Region: PBP1_GalR; cd01544 471223005479 putative dimerization interface [polypeptide binding]; other site 471223005480 putative ligand binding site [chemical binding]; other site 471223005481 aldose 1-epimerase superfamily; Region: Aldose_epim; cl14648 471223005482 aldose 1-epimerase superfamily; Region: Aldose_epim; cl14648 471223005483 active site 471223005484 catalytic residues [active] 471223005485 Transposase; Region: DEDD_Tnp_IS110; pfam01548 471223005486 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 471223005487 UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087 471223005488 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 471223005489 NAD binding site [chemical binding]; other site 471223005490 homodimer interface [polypeptide binding]; other site 471223005491 active site 471223005492 substrate binding site [chemical binding]; other site 471223005493 galactokinase; Provisional; Region: PRK05322 471223005494 Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509 471223005495 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 471223005496 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 471223005497 EcsC protein family; Region: EcsC; pfam12787 471223005498 Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578 471223005499 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 471223005500 Transposase; Region: DEDD_Tnp_IS110; pfam01548 471223005501 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 471223005502 Transposase; Region: DEDD_Tnp_IS110; pfam01548 471223005503 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 471223005504 DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808 471223005505 Glycerol-3-phosphate responsive antiterminator; Region: G3P_antiterm; cl00852 471223005506 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 471223005507 ATP binding site [chemical binding]; other site 471223005508 Mg2+ binding site [ion binding]; other site 471223005509 G-X-G motif; other site 471223005510 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 471223005511 transposase, putative, N-terminal domain; Region: tspaseT_teng_N; TIGR01765 471223005512 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 471223005513 Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282 471223005514 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 471223005515 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 471223005516 putative dimer interface [polypeptide binding]; other site 471223005517 FO synthase subunit 1; Reviewed; Region: cofG; PRK06245 471223005518 YppG-like protein; Region: YppG; pfam14179 471223005519 YppF-like protein; Region: YppF; pfam14178 471223005520 Bacterial domain of unknown function (DUF1798); Region: DUF1798; pfam08807 471223005521 Recombination protein U; Region: RecU; cl01314 471223005522 Transglycosylase; Region: Transgly; cl07896 471223005523 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 471223005524 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 471223005525 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 471223005526 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 471223005527 minor groove reading motif; other site 471223005528 helix-hairpin-helix signature motif; other site 471223005529 substrate binding pocket [chemical binding]; other site 471223005530 active site 471223005531 Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; cl15304 471223005532 Putative primosome component and related proteins [DNA replication, recombination, and repair]; Region: DnaD; COG3935 471223005533 Helix-turn-helix domains; Region: HTH; cl00088 471223005534 Replication initiation and membrane attachment; Region: DnaB_2; cl12121 471223005535 asparaginyl-tRNA synthetase; Validated; Region: asnC; PRK03932 471223005536 AsnRS_cyto_like_N: N-terminal, anticodon recognition domain of the type found in human and Saccharomyces cerevisiae cytoplasmic asparaginyl-tRNA synthetase (AsnRS), in Brugia malayai AsnRs and, in various putative bacterial AsnRSs. This domain is a...; Region: AsnRS_cyto_like_N; cd04323 471223005537 putative dimer interface [polypeptide binding]; other site 471223005538 putative anticodon binding site; other site 471223005539 Asx tRNA synthetase (AspRS/AsnRS) class II core domain. Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776 471223005540 homodimer interface [polypeptide binding]; other site 471223005541 motif 1; other site 471223005542 motif 2; other site 471223005543 active site 471223005544 motif 3; other site 471223005545 aspartate aminotransferase; Provisional; Region: PRK05764 471223005546 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 471223005547 pyridoxal 5'-phosphate binding site [chemical binding]; other site 471223005548 homodimer interface [polypeptide binding]; other site 471223005549 catalytic residue [active] 471223005550 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5353 471223005551 Peptidase propeptide and YPEB domain; Region: PepSY; cl15815 471223005552 Protein of unknown function (DUF4264); Region: DUF4264; pfam14084 471223005553 bifunctional ATP-dependent DNA helicase/DNA polymerase III subunit epsilon; Validated; Region: PRK08074 471223005554 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 471223005555 active site 471223005556 substrate binding site [chemical binding]; other site 471223005557 catalytic site [active] 471223005558 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 471223005559 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 471223005560 putative Mg++ binding site [ion binding]; other site 471223005561 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 471223005562 Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919 471223005563 tetramerization interface [polypeptide binding]; other site 471223005564 active site 471223005565 pantoate--beta-alanine ligase; Region: panC; TIGR00018 471223005566 Pantoate-beta-alanine ligase; Region: PanC; cd00560 471223005567 active site 471223005568 ATP-binding site [chemical binding]; other site 471223005569 pantoate-binding site; other site 471223005570 HXXH motif; other site 471223005571 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 471223005572 oligomerization interface [polypeptide binding]; other site 471223005573 active site 471223005574 metal binding site [ion binding]; metal-binding site 471223005575 Helix-turn-helix domains; Region: HTH; cl00088 471223005576 bifunctional biotin--[acetyl-CoA-carboxylase] synthetase/biotin operon repressor; Provisional; Region: PRK11886 471223005577 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 471223005578 Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237 471223005579 tRNA CCA-pyrophosphorylase; Provisional; Region: PRK13299 471223005580 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 471223005581 active site 471223005582 NTP binding site [chemical binding]; other site 471223005583 metal binding triad [ion binding]; metal-binding site 471223005584 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 471223005585 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 471223005586 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_5; cd04962 471223005587 N-acetyl-alpha-D-glucosaminyl L-malate synthase BshA; Region: thiol_BshA; TIGR03999 471223005588 GlcNAc-PI de-N-acetylase; Region: PIG-L; cl00929 471223005589 Methylglyoxal synthase catalyzes the enolization of dihydroxyacetone phosphate (DHAP) to produce methylglyoxal. The first part of the catalytic mechanism is believed to be similar to TIM (triosephosphate isomerase) in that both enzymes utilize DHAP to...; Region: MGS; cd01422 471223005590 active site 471223005591 dimer interfaces [polypeptide binding]; other site 471223005592 catalytic residues [active] 471223005593 dihydrodipicolinate reductase; Provisional; Region: PRK00048 471223005594 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 471223005595 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 471223005596 MazG nucleotide pyrophosphohydrolase domain; Region: MazG; cl00345 471223005597 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 471223005598 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 471223005599 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; cl10498 471223005600 Sporulation protein YpjB (SpoYpjB); Region: Spore_YpjB; cl09800 471223005601 Protein of unknown function (DUF1405); Region: DUF1405; cl01798 471223005602 Cytochrome b(C-terminus)/b6/petD: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: cytochrome_b_C; cl00193 471223005603 Cytochrome c; Region: Cytochrom_C; cl11414 471223005604 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cd00284 471223005605 interchain domain interface [polypeptide binding]; other site 471223005606 intrachain domain interface; other site 471223005607 heme bH binding site [chemical binding]; other site 471223005608 Qi binding site; other site 471223005609 heme bL binding site [chemical binding]; other site 471223005610 Qo binding site; other site 471223005611 Rieske Fe-S protein [Energy production and conversion]; Region: QcrA; COG0723 471223005612 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467 471223005613 iron-sulfur cluster [ion binding]; other site 471223005614 [2Fe-2S] cluster binding site [ion binding]; other site 471223005615 Protein of unknown function (DUF2487); Region: DUF2487; pfam10673 471223005616 hypothetical protein; Provisional; Region: PRK03636 471223005617 UPF0302 domain; Region: UPF0302; pfam08864 471223005618 IDEAL domain; Region: IDEAL; cl07452 471223005619 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 471223005620 binding surface 471223005621 TPR motif; other site 471223005622 Tetratricopeptide repeat; Region: TPR_12; pfam13424 471223005623 Tfp pilus assembly protein PilF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilF; COG3063 471223005624 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 471223005625 binding surface 471223005626 TPR motif; other site 471223005627 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 471223005628 binding surface 471223005629 TPR motif; other site 471223005630 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 471223005631 3-phosphoshikimate 1-carboxyvinyltransferase; Region: aroA; TIGR01356 471223005632 hinge; other site 471223005633 active site 471223005634 prephenate dehydrogenase; Validated; Region: PRK06545 471223005635 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 471223005636 NAD(P) binding site [chemical binding]; other site 471223005637 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 471223005638 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 471223005639 histidinol-phosphate aminotransferase; Validated; Region: PRK02731 471223005640 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 471223005641 pyridoxal 5'-phosphate binding site [chemical binding]; other site 471223005642 homodimer interface [polypeptide binding]; other site 471223005643 catalytic residue [active] 471223005644 tryptophan synthase subunit alpha; Provisional; Region: trpA; PRK13111 471223005645 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 471223005646 substrate binding site [chemical binding]; other site 471223005647 active site 471223005648 catalytic residues [active] 471223005649 heterodimer interface [polypeptide binding]; other site 471223005650 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 471223005651 Pyridoxal-phosphate dependent enzyme; Region: PALP; pfam00291 471223005652 pyridoxal 5'-phosphate binding site [chemical binding]; other site 471223005653 catalytic residue [active] 471223005654 Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are monomeric; Region: PRAI; cd00405 471223005655 active site 471223005656 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 471223005657 active site 471223005658 ribulose/triose binding site [chemical binding]; other site 471223005659 phosphate binding site [ion binding]; other site 471223005660 substrate (anthranilate) binding pocket [chemical binding]; other site 471223005661 product (indole) binding pocket [chemical binding]; other site 471223005662 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 471223005663 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 471223005664 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 471223005665 anthranilate synthase component I; Provisional; Region: PRK13569 471223005666 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 471223005667 chorismate binding enzyme; Region: Chorismate_bind; cl10555 471223005668 Chorismate mutase (AroH) is one of at least five chorismate-utilizing enzymes present in microorganisms that catalyze the rearrangement of chorismate to prephenic acid, the first committed step in the biosynthesis of aromatic amino acids. In prokaryotes; Region: AroH; cd02185 471223005669 homotrimer interaction site [polypeptide binding]; other site 471223005670 active site 471223005671 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 471223005672 active site 471223005673 dimer interface [polypeptide binding]; other site 471223005674 metal binding site [ion binding]; metal-binding site 471223005675 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 471223005676 Tetramer interface [polypeptide binding]; other site 471223005677 active site 471223005678 FMN-binding site [chemical binding]; other site 471223005679 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 471223005680 Methyltransferase, chemotaxis proteins; Region: MeTrc; smart00138 471223005681 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 471223005682 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 471223005683 active site 471223005684 multimer interface [polypeptide binding]; other site 471223005685 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 471223005686 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 471223005687 substrate binding pocket [chemical binding]; other site 471223005688 chain length determination region; other site 471223005689 substrate-Mg2+ binding site; other site 471223005690 catalytic residues [active] 471223005691 aspartate-rich region 1; other site 471223005692 active site lid residues [active] 471223005693 aspartate-rich region 2; other site 471223005694 ubiE/COQ5 methyltransferase family; Region: Ubie_methyltran; pfam01209 471223005695 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 471223005696 S-adenosylmethionine binding site [chemical binding]; other site 471223005697 Heptaprenyl diphosphate synthase (HEPPP synthase) subunit 1; Region: HEPPP_synt_1; pfam07307 471223005698 Tryptophan RNA-binding attenuator protein; Region: TrpBP; cl03437 471223005699 GTP cyclohydrolase I (GTP-CH-I) catalyzes the conversion of GTP into dihydroneopterin triphosphate. The enzyme product is the precursor of tetrahydrofolate in eubacteria, fungi, and plants and of the folate analogs in methanogenic bacteria. In...; Region: GTP_cyclohydro1; cd00642 471223005700 homodecamer interface [polypeptide binding]; other site 471223005701 GTP cyclohydrolase I; Provisional; Region: PLN03044 471223005702 active site 471223005703 putative catalytic site residues [active] 471223005704 zinc binding site [ion binding]; other site 471223005705 GTP-CH-I/GFRP interaction surface; other site 471223005706 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 471223005707 IHF dimer interface [polypeptide binding]; other site 471223005708 IHF - DNA interface [nucleotide binding]; other site 471223005709 Stage IV sporulation protein A (spore_IV_A); Region: Spore_IV_A; cl09772 471223005710 Protein of unknown function (DUF2768); Region: DUF2768; pfam10966 471223005711 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 471223005712 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 471223005713 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 471223005714 GTP-binding protein Der; Reviewed; Region: PRK00093 471223005715 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 471223005716 G1 box; other site 471223005717 GTP/Mg2+ binding site [chemical binding]; other site 471223005718 Switch I region; other site 471223005719 G2 box; other site 471223005720 Switch II region; other site 471223005721 G3 box; other site 471223005722 G4 box; other site 471223005723 G5 box; other site 471223005724 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 471223005725 G1 box; other site 471223005726 GTP/Mg2+ binding site [chemical binding]; other site 471223005727 Switch I region; other site 471223005728 G2 box; other site 471223005729 G3 box; other site 471223005730 Switch II region; other site 471223005731 G4 box; other site 471223005732 G5 box; other site 471223005733 YIEGIA protein; Region: YIEGIA; pfam14045 471223005734 YpzI-like protein; Region: YpzI; pfam14140 471223005735 Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; cl05194 471223005736 Spore germination protein; Region: Spore_permease; cl15802 471223005737 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 471223005738 isopentenyl pyrophosphate isomerase; Provisional; Region: PRK05437 471223005739 Isopentenyl-diphosphate:dimethylallyl diphosphate isomerase type 2 (IDI-2) FMN-binding domain. Two types of IDIs have been characterized at present. The long known IDI-1 is only dependent on divalent metals for activity, whereas IDI-2 requires a metal; Region: IDI-2_FMN; cd02811 471223005740 homotetramer interface [polypeptide binding]; other site 471223005741 FMN binding site [chemical binding]; other site 471223005742 homodimer contacts [polypeptide binding]; other site 471223005743 putative active site [active] 471223005744 putative substrate binding site [chemical binding]; other site 471223005745 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06676 471223005746 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 471223005747 RNA binding site [nucleotide binding]; other site 471223005748 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 471223005749 RNA binding site [nucleotide binding]; other site 471223005750 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 471223005751 RNA binding site [nucleotide binding]; other site 471223005752 S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists of...; Region: S1_RPS1_repeat_hs4; cd05692 471223005753 RNA binding site [nucleotide binding]; other site 471223005754 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 471223005755 putative acyl-acceptor binding pocket; other site 471223005756 cytidylate kinase; Provisional; Region: cmk; PRK00023 471223005757 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 471223005758 CMP-binding site; other site 471223005759 The sites determining sugar specificity; other site 471223005760 c-di-GMP-binding protein [Signal transduction mechanisms]; Region: COG5581 471223005761 Flagellar protein YcgR; Region: YcgR_2; pfam12945 471223005762 PilZ domain; Region: PilZ; cl01260 471223005763 germination protein YpeB; Region: spore_YpeB; TIGR02889 471223005764 spore cortex-lytic enzyme; Region: spore_SleB; TIGR02869 471223005765 Putative peptidoglycan binding domain; Region: PG_binding_1; cl15437 471223005766 Cell Wall Hydrolase; Region: Hydrolase_2; pfam07486 471223005767 Protease prsW family; Region: PrsW-protease; cl15823 471223005768 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 471223005769 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 471223005770 Probable transposase; Region: OrfB_IS605; pfam01385 471223005771 Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282 471223005772 Transposase IS200 like; Region: Y1_Tnp; cl00848 471223005773 DDE superfamily endonuclease; Region: DDE_5; cl02413 471223005774 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 471223005775 Archaeal putative transposase ISC1217; Region: DDE_Tnp_2; pfam04693 471223005776 Type II (periplasmic) bacterial L-asparaginase; Region: L-asparaginase_II; cd08964 471223005777 active site 471223005778 homotetramer interface [polypeptide binding]; other site 471223005779 homodimer interface [polypeptide binding]; other site 471223005780 putative bacillithiol system oxidoreductase, YpdA family; Region: Bthiol_YpdA; TIGR04018 471223005781 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 471223005782 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 471223005783 Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334 471223005784 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 471223005785 NAD(P) binding domain of glutamate dehydrogenase, subgroup 1; Region: NAD_bind_1_Glu_DH; cd01076 471223005786 NAD(P) binding site [chemical binding]; other site 471223005787 Negative regulator of genetic competence (MecA); Region: MecA; cl02022 471223005788 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 471223005789 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 471223005790 putative active site [active] 471223005791 putative metal binding site [ion binding]; other site 471223005792 Spore coat associated protein JA (CotJA); Region: CotJA; pfam11007 471223005793 CotJB protein; Region: CotJB; pfam12652 471223005794 Manganese catalase, ferritin-like diiron-binding domain; Region: Mn_catalase; cd01051 471223005795 dimanganese center [ion binding]; other site 471223005796 Protein of unknown function (DUF2663); Region: DUF2663; pfam10864 471223005797 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118 471223005798 putative peptidoglycan binding site; other site 471223005799 CAAX protease self-immunity; Region: Abi; cl00558 471223005800 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 471223005801 ATP binding site [chemical binding]; other site 471223005802 putative Mg++ binding site [ion binding]; other site 471223005803 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 471223005804 nucleotide binding region [chemical binding]; other site 471223005805 ATP-binding site [chemical binding]; other site 471223005806 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4955 471223005807 4Fe-4S single cluster domain; Region: Fer4_13; pfam13370 471223005808 Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412 471223005809 dimer interface [polypeptide binding]; other site 471223005810 substrate binding site [chemical binding]; other site 471223005811 metal binding sites [ion binding]; metal-binding site 471223005812 D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK13581 471223005813 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 471223005814 C-terminal ACT (regulatory) domain of D-3-phosphoglycerate dehydrogenase (3PGDH); Region: ACT_3PGDH-xct; cd04902 471223005815 putative L-serine binding site [chemical binding]; other site 471223005816 histidinol-phosphatase; Provisional; Region: PRK07328 471223005817 RNA polymerase sigma factor SigX; Provisional; Region: PRK09639 471223005818 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 471223005819 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 471223005820 DNA binding residues [nucleotide binding] 471223005821 AIR synthase related protein, N-terminal domain; Region: AIRS; pfam00586 471223005822 Cobalamin adenosyltransferase; Region: Cob_adeno_trans; cl00920 471223005823 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 471223005824 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 471223005825 catalytic core [active] 471223005826 Cobalamin-5-phosphate synthase; Region: CobS; cl00415 471223005827 Adenosylcobinamide kinase / adenosylcobinamide phosphate guanyltransferase (CobU). CobU is bifunctional cobalbumin biosynthesis enzymes which display adenosylcobinamide kinase and adenosylcobinamide phosphate guanyltransferase activity. This enzyme is a...; Region: CobU; cd00544 471223005828 homotrimer interface [polypeptide binding]; other site 471223005829 Walker A motif; other site 471223005830 GTP binding site [chemical binding]; other site 471223005831 Walker B motif; other site 471223005832 L-threonine-O-3-phosphate decarboxylase; Region: L_thr_O3P_dcar; TIGR01140 471223005833 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 471223005834 pyridoxal 5'-phosphate binding site [chemical binding]; other site 471223005835 homodimer interface [polypeptide binding]; other site 471223005836 catalytic residue [active] 471223005837 CobD/Cbib protein; Region: CobD_Cbib; cl00561 471223005838 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 471223005839 ABC transporters, involved in the uptake of siderophores, heme, and vitamin B12, are widely conserved in bacteria and archaea. Only very few species lack representatives of the siderophore family transporters. The E. coli BtuCD protein is an ABC...; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 471223005840 Walker A/P-loop; other site 471223005841 ATP binding site [chemical binding]; other site 471223005842 Q-loop/lid; other site 471223005843 ABC transporter signature motif; other site 471223005844 Walker B; other site 471223005845 D-loop; other site 471223005846 H-loop/switch region; other site 471223005847 Adenosylcobinamide amidohydrolase; Region: CbiZ; cl00808 471223005848 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 471223005849 ABC-ATPase subunit interface; other site 471223005850 dimer interface [polypeptide binding]; other site 471223005851 putative PBP binding regions; other site 471223005852 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 471223005853 Periplasmic binding protein YvrC. These proteins are predicted to function as initial receptors in ABC transport of metal ions in eubacteria and archaea. They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct...; Region: YvrC; cd01143 471223005854 putative binding site residues; other site 471223005855 Protein of unknown function (DUF1696); Region: DUF1696; pfam08000 471223005856 YvbH-like oligomerisation region; Region: YvbH_ext; pfam11724 471223005857 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 471223005858 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 471223005859 DNA-binding site [nucleotide binding]; DNA binding site 471223005860 UTRA domain; Region: UTRA; cl01230 471223005861 GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399 471223005862 active site 471223005863 trimer interface [polypeptide binding]; other site 471223005864 allosteric site; other site 471223005865 active site lid [active] 471223005866 hexamer (dimer of trimers) interface [polypeptide binding]; other site 471223005867 N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820 471223005868 N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854 471223005869 active site 471223005870 dimer interface [polypeptide binding]; other site 471223005871 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: VicK; COG5002 471223005872 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 471223005873 dimerization interface [polypeptide binding]; other site 471223005874 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 471223005875 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 471223005876 dimer interface [polypeptide binding]; other site 471223005877 phosphorylation site [posttranslational modification] 471223005878 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 471223005879 ATP binding site [chemical binding]; other site 471223005880 Mg2+ binding site [ion binding]; other site 471223005881 G-X-G motif; other site 471223005882 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 471223005883 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 471223005884 active site 471223005885 phosphorylation site [posttranslational modification] 471223005886 intermolecular recognition site; other site 471223005887 dimerization interface [polypeptide binding]; other site 471223005888 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 471223005889 DNA binding site [nucleotide binding] 471223005890 Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504 471223005891 Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504 471223005892 ResB protein required for cytochrome c biosynthesis [Posttranslational modification, protein turnover, chaperones]; Region: ResB; cl09125 471223005893 ResB-like family; Region: ResB; pfam05140 471223005894 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 471223005895 catalytic residues [active] 471223005896 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 471223005897 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 471223005898 RNA binding surface [nucleotide binding]; other site 471223005899 Pseudouridine synthases are responsible for the synthesis of pseudouridine from uracil in ribosomal RNA. The RsuA subfamily includes Pseudouridine Synthase similar to Ribosomal small subunit pseudouridine 516 synthase. Most of the proteins in this...; Region: PseudoU_synth_RsuA_like; cd02870 471223005900 active site 471223005901 Nucleoside recognition; Region: Gate; cl00486 471223005902 Nucleoside recognition; Region: Gate; cl00486 471223005903 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 471223005904 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 471223005905 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; cl06814 471223005906 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 471223005907 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 471223005908 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 471223005909 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 471223005910 transposase, putative, N-terminal domain; Region: tspaseT_teng_N; TIGR01765 471223005911 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 471223005912 Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282 471223005913 Protein of unknown function (DUF3907); Region: DUF3907; pfam13047 471223005914 Putative transcriptional regulators (Ypuh-like); Region: DUF387; cl00612 471223005915 ScpA/B protein; Region: ScpA_ScpB; cl00598 471223005916 Domain of unknown function (DUF309); Region: DUF309; cl00667 471223005917 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 471223005918 Coenzyme A binding pocket [chemical binding]; other site 471223005919 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 471223005920 homopentamer interface [polypeptide binding]; other site 471223005921 active site 471223005922 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09311 471223005923 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; cl00336 471223005924 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 471223005925 dimerization interface [polypeptide binding]; other site 471223005926 active site 471223005927 riboflavin synthase subunit alpha; Provisional; Region: PRK09289 471223005928 Lumazine binding domain; Region: Lum_binding; pfam00677 471223005929 Lumazine binding domain; Region: Lum_binding; pfam00677 471223005930 riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326 471223005931 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 471223005932 catalytic motif [active] 471223005933 Zn binding site [ion binding]; other site 471223005934 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cl00161 471223005935 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 471223005936 transposase, putative, N-terminal domain; Region: tspaseT_teng_N; TIGR01765 471223005937 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 471223005938 Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282 471223005939 Protein of unknown function (DUF1002); Region: DUF1002; pfam06207 471223005940 diaminopimelate decarboxylase; Region: lysA; TIGR01048 471223005941 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 471223005942 active site 471223005943 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 471223005944 substrate binding site [chemical binding]; other site 471223005945 catalytic residues [active] 471223005946 dimer interface [polypeptide binding]; other site 471223005947 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 471223005948 Stage V sporulation protein AE1; Region: SpoVAE; pfam14097 471223005949 SpoVA protein; Region: SpoVA; cl04298 471223005950 stage V sporulation protein AD; Validated; Region: PRK08304 471223005951 stage V sporulation protein AD; Provisional; Region: PRK12404 471223005952 SpoVA protein; Region: SpoVA; cl04298 471223005953 Stage V sporulation protein AB; Region: SpoVAB; pfam13782 471223005954 Stage V sporulation protein AA; Region: SporV_AA; pfam12164 471223005955 sporulation sigma factor SigF; Validated; Region: PRK05572 471223005956 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 471223005957 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 471223005958 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 471223005959 DNA binding residues [nucleotide binding] 471223005960 Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms]; Region: RsbW; COG2172 471223005961 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 471223005962 ATP binding site [chemical binding]; other site 471223005963 Mg2+ binding site [ion binding]; other site 471223005964 G-X-G motif; other site 471223005965 Sulphate Transporter and Anti-Sigma factor antagonist domain found in the C-terminal region of sulphate transporters as well as in bacterial and archaeal proteins involved in the regulation of sigma factors; Region: STAS; cd06844 471223005966 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 471223005967 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 471223005968 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; cl06814 471223005969 pyrimidine-nucleoside phosphorylase; Reviewed; Region: PRK06078 471223005970 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 471223005971 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 471223005972 Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; cl06734 471223005973 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 471223005974 Sulfatase; Region: Sulfatase; cl10460 471223005975 Metalloenzyme superfamily; Region: Metalloenzyme; pfam01676 471223005976 site-specific tyrosine recombinase XerD; Reviewed; Region: xerD; PRK00283 471223005977 XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798 471223005978 Int/Topo IB signature motif; other site 471223005979 active site 471223005980 Protein of unknown function (DUF4227); Region: DUF4227; pfam14004 471223005981 ferric uptake regulator; Provisional; Region: fur; PRK09462 471223005982 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 471223005983 metal binding site 2 [ion binding]; metal-binding site 471223005984 putative DNA binding helix; other site 471223005985 metal binding site 1 [ion binding]; metal-binding site 471223005986 dimer interface [polypeptide binding]; other site 471223005987 structural Zn2+ binding site [ion binding]; other site 471223005988 Integral membrane protein DUF95; Region: DUF95; cl00572 471223005989 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 471223005990 transposase, putative, N-terminal domain; Region: tspaseT_teng_N; TIGR01765 471223005991 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 471223005992 Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282 471223005993 PHP family phosphoesterase with a Zn ribbon [General function prediction only]; Region: COG1379 471223005994 PHP-associated; Region: PHP_C; pfam13263 471223005995 H3TH domains of structure-specific 5' nucleases (or flap endonuclease-1-like) involved in DNA replication, repair, and recombination; Region: H3TH_StructSpec-5'-nucleases; cl14815 471223005996 DNA binding site [nucleotide binding] 471223005997 nudix-type nucleoside diphosphatase, YffH/AdpP family; Region: TIGR00052 471223005998 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 471223005999 dimer interface [polypeptide binding]; other site 471223006000 ADP-ribose binding site [chemical binding]; other site 471223006001 active site 471223006002 nudix motif; other site 471223006003 metal binding site [ion binding]; metal-binding site 471223006004 Predicted oxidoreductases (related to aryl-alcohol dehydrogenases) [Energy production and conversion]; Region: Tas; COG0667 471223006005 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 471223006006 active site 471223006007 catalytic tetrad [active] 471223006008 Protein of unknown function (DUF2552); Region: DUF2552; pfam10827 471223006009 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4918 471223006010 Iron-binding zinc finger CDGSH type; Region: zf-CDGSH; cl02748 471223006011 YqzH-like protein; Region: YqzH; pfam14164 471223006012 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 471223006013 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 471223006014 NAD(P) binding site [chemical binding]; other site 471223006015 active site 471223006016 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 471223006017 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 471223006018 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 471223006019 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880 471223006020 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 471223006021 transposase, putative, N-terminal domain; Region: tspaseT_teng_N; TIGR01765 471223006022 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 471223006023 Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282 471223006024 Old yellow enzyme (OYE) YqjM-like FMN binding domain. YqjM is involved in the oxidative stress response of Bacillus subtilis. Like the other OYE members, each monomer of YqjM contains FMN as a non-covalently bound cofactor and uses NADPH as a reducing...; Region: OYE_YqiM_FMN; cd02932 471223006025 active site 471223006026 FMN binding site [chemical binding]; other site 471223006027 substrate binding site [chemical binding]; other site 471223006028 homotetramer interface [polypeptide binding]; other site 471223006029 catalytic residue [active] 471223006030 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 471223006031 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 471223006032 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 471223006033 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 471223006034 Putative cyclase; Region: Cyclase; cl00814 471223006035 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 471223006036 6-phosphogluconate dehydrogenase; Validated; Region: PRK09287 471223006037 6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393 471223006038 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 471223006039 active site 471223006040 NTP binding site [chemical binding]; other site 471223006041 metal binding triad [ion binding]; metal-binding site 471223006042 antibiotic binding site [chemical binding]; other site 471223006043 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256 471223006044 M20 Peptidase T like enzymes specifically cleave tripeptides; Region: M20_peptT_like; cd05683 471223006045 peptidase T-like protein; Region: PepT-like; TIGR01883 471223006046 metal binding site [ion binding]; metal-binding site 471223006047 putative dimer interface [polypeptide binding]; other site 471223006048 methylmalonyl-CoA decarboxylase alpha subunit; Region: mmdA; TIGR01117 471223006049 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl15772 471223006050 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl15772 471223006051 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 471223006052 Methylmalonyl-CoA epimerase (MMCE); Region: MMCE; cd07249 471223006053 dimer interface [polypeptide binding]; other site 471223006054 substrate binding site [chemical binding]; other site 471223006055 metal binding site [ion binding]; metal-binding site 471223006056 L,D-transpeptidase catalytic domain; Region: YkuD; cl15405 471223006057 Predicted membrane protein [Function unknown]; Region: COG4129 471223006058 Fusaric acid resistance protein-like; Region: FUSC_2; cl15844 471223006059 DUF939 C-terminal domain; Region: DUF939_C; pfam11728 471223006060 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 471223006061 HisP and GlnQ are the ATP-binding components of the bacterial periplasmic histidine and glutamine permeases, repectively. Histidine permease is a multisubunit complex containing the HisQ and HisM integral membrane subunits and two copies of HisP. HisP...; Region: ABC_HisP_GlnQ_permeases; cd03262 471223006062 Walker A/P-loop; other site 471223006063 ATP binding site [chemical binding]; other site 471223006064 Q-loop/lid; other site 471223006065 ABC transporter signature motif; other site 471223006066 Walker B; other site 471223006067 D-loop; other site 471223006068 H-loop/switch region; other site 471223006069 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 471223006070 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 471223006071 dimer interface [polypeptide binding]; other site 471223006072 conserved gate region; other site 471223006073 putative PBP binding loops; other site 471223006074 ABC-ATPase subunit interface; other site 471223006075 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 471223006076 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 471223006077 substrate binding pocket [chemical binding]; other site 471223006078 membrane-bound complex binding site; other site 471223006079 hinge residues; other site 471223006080 Disulphide isomerase; Region: Disulph_isomer; pfam06491 471223006081 membrane ATPase/protein kinase; Provisional; Region: PRK09435 471223006082 The function of this protein family is unkown. The protein sequences are similar to the ArgK protein in E. coli. ArgK protein is a membrane ATPase which is required for transporting arginine, ornithine and lysine into the cells by the arginine and...; Region: ArgK-like; cd03114 471223006083 Walker A; other site 471223006084 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 471223006085 G4 box; other site 471223006086 G5 box; other site 471223006087 methylmalonyl-CoA mutase; Reviewed; Region: PRK09426 471223006088 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM) family, Alpha subunit-like subfamily; contains proteins similar to the alpha subunit of Propionbacterium shermanni MCM, as well as human and E. coli MCM. Members of this subfamily contain...; Region: MM_CoA_mutase_alpha_like; cd03679 471223006089 active site 471223006090 substrate binding site [chemical binding]; other site 471223006091 coenzyme B12 binding site [chemical binding]; other site 471223006092 methylmalonyl CoA mutase B12 binding domain. This domain binds to B12 (adenosylcobamide), which initiates the conversion of succinyl CoA and methylmalonyl CoA by forming an adenosyl radical, which then undergoes a rearrangement exchanging a hydrogen atom...; Region: MM_CoA_mut_B12_BD; cd02071 471223006093 B12 binding site [chemical binding]; other site 471223006094 cobalt ligand [ion binding]; other site 471223006095 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM) family, Beta subunit-like subfamily; contains bacterial proteins similar to the beta subunit of MCMs from Propionbacterium shermanni and Streptomyces cinnamonensis, which are alpha/beta...; Region: MM_CoA_mutase_beta; cd03677 471223006096 heterodimer interface [polypeptide binding]; other site 471223006097 Methylmalonyl-CoA mutase, N-terminal domain/subunit [Lipid metabolism]; Region: Sbm; COG1884 471223006098 substrate interaction site [chemical binding]; other site 471223006099 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 471223006100 putative bacteriocin export ABC transporter, lactococcin 972 group; Region: L_ocin_972_ABC; TIGR03608 471223006101 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 471223006102 Walker A/P-loop; other site 471223006103 ATP binding site [chemical binding]; other site 471223006104 Q-loop/lid; other site 471223006105 ABC transporter signature motif; other site 471223006106 Walker B; other site 471223006107 D-loop; other site 471223006108 H-loop/switch region; other site 471223006109 Bacteriocin (Lactococcin_972); Region: Lactococcin_972; cl09891 471223006110 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 471223006111 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 471223006112 E3 interaction surface; other site 471223006113 lipoyl attachment site [posttranslational modification]; other site 471223006114 e3 binding domain; Region: E3_binding; pfam02817 471223006115 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; cl02008 471223006116 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 471223006117 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 471223006118 alpha subunit interface [polypeptide binding]; other site 471223006119 TPP binding site [chemical binding]; other site 471223006120 heterodimer interface [polypeptide binding]; other site 471223006121 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 471223006122 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit [Energy production and conversion]; Region: AcoA; COG1071 471223006123 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 471223006124 tetramer interface [polypeptide binding]; other site 471223006125 TPP-binding site [chemical binding]; other site 471223006126 heterodimer interface [polypeptide binding]; other site 471223006127 phosphorylation loop region [posttranslational modification] 471223006128 dihydrolipoamide dehydrogenase; Validated; Region: PRK05976 471223006129 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 471223006130 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 471223006131 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 471223006132 Acetokinase family; Region: Acetate_kinase; cl01029 471223006133 Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334 471223006134 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 471223006135 NAD(P) binding domain of leucine dehydrogenase, phenylalanine dehydrogenase, and valine dehydrogenase; Region: NAD_bind_Leu_Phe_Val_DH; cd01075 471223006136 NAD binding site [chemical binding]; other site 471223006137 Phe binding site; other site 471223006138 Phosphate acetyl/butaryl transferase; Region: PTA_PTB; cl00390 471223006139 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 471223006140 Transcriptional regulator containing PAS, AAA-type ATPase, and DNA-binding domains [Transcription / Signal transduction mechanisms]; Region: RocR; COG3829 471223006141 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 471223006142 putative active site [active] 471223006143 heme pocket [chemical binding]; other site 471223006144 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 471223006145 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 471223006146 Walker A motif; other site 471223006147 ATP binding site [chemical binding]; other site 471223006148 Walker B motif; other site 471223006149 arginine finger; other site 471223006150 Helix-turn-helix domains; Region: HTH; cl00088 471223006151 Protein of unknown function (DUF2627); Region: DUF2627; pfam11118 471223006152 Glycerophosphodiester phosphodiesterase domain of Thermoanaerobacter tengcongensis and similar proteins; Region: GDPD_TtGDE_like; cd08563 471223006153 Glycerophosphoryl diester phosphodiesterase family; Region: GDPD; pfam03009 471223006154 active site 471223006155 catalytic site [active] 471223006156 metal binding site [ion binding]; metal-binding site 471223006157 dimer interface [polypeptide binding]; other site 471223006158 YycC-like protein; Region: YycC; pfam14174 471223006159 sporulation transcription factor Spo0A; Region: spore_0_A; TIGR02875 471223006160 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 471223006161 active site 471223006162 phosphorylation site [posttranslational modification] 471223006163 intermolecular recognition site; other site 471223006164 dimerization interface [polypeptide binding]; other site 471223006165 Sporulation initiation factor Spo0A C terminal; Region: Spo0A_C; pfam08769 471223006166 stage IV sporulation protein B; Region: spore_IV_B; TIGR02860 471223006167 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 471223006168 SpoIVB peptidase S55; Region: Peptidase_S55; pfam05580 471223006169 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497 471223006170 RecN ATPase involved in DNA repair; ABC (ATP-binding cassette) transporter nucleotide-binding domain; ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds including sugars, ions, peptides, and...; Region: ABC_RecN; cd03241 471223006171 Walker A/P-loop; other site 471223006172 ATP binding site [chemical binding]; other site 471223006173 Q-loop/lid; other site 471223006174 RecN ATPase involved in DNA repair; ABC (ATP-binding cassette) transporter nucleotide-binding domain; ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds including sugars, ions, peptides, and...; Region: ABC_RecN; cd03241 471223006175 Q-loop/lid; other site 471223006176 ABC transporter signature motif; other site 471223006177 Walker B; other site 471223006178 D-loop; other site 471223006179 H-loop/switch region; other site 471223006180 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 471223006181 arginine repressor; Provisional; Region: PRK04280 471223006182 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 471223006183 Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189 471223006184 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 471223006185 RNA binding surface [nucleotide binding]; other site 471223006186 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl15754 471223006187 1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444 471223006188 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 471223006189 TPP-binding site; other site 471223006190 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 471223006191 PYR/PP interface [polypeptide binding]; other site 471223006192 dimer interface [polypeptide binding]; other site 471223006193 TPP binding site [chemical binding]; other site 471223006194 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 471223006195 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 471223006196 substrate binding pocket [chemical binding]; other site 471223006197 chain length determination region; other site 471223006198 substrate-Mg2+ binding site; other site 471223006199 catalytic residues [active] 471223006200 aspartate-rich region 1; other site 471223006201 active site lid residues [active] 471223006202 aspartate-rich region 2; other site 471223006203 Exonuclease VII small subunit; Region: Exonuc_VII_S; cl00750 471223006204 transposase, putative, N-terminal domain; Region: tspaseT_teng_N; TIGR01765 471223006205 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 471223006206 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 471223006207 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 471223006208 generic binding surface II; other site 471223006209 generic binding surface I; other site 471223006210 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14190 471223006211 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 471223006212 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 471223006213 homodimer interface [polypeptide binding]; other site 471223006214 NADP binding site [chemical binding]; other site 471223006215 substrate binding site [chemical binding]; other site 471223006216 Transcription termination factor NusB (N protein-Utilization Substance B). NusB plays a key role in the regulation of ribosomal RNA biosynthesis in eubacteria by modulating the efficiency of transcriptional antitermination. NusB along with other Nus...; Region: Terminator_NusB; cd00619 471223006217 putative RNA binding site [nucleotide binding]; other site 471223006218 Asp23 family; Region: Asp23; cl00574 471223006219 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 471223006220 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 471223006221 ATP-grasp domain; Region: ATP-grasp_4; cl03087 471223006222 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; cl08365 471223006223 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302 471223006224 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 471223006225 carboxyltransferase (CT) interaction site; other site 471223006226 biotinylation site [posttranslational modification]; other site 471223006227 SpoIIIAH-like protein; Region: SpoIIIAH; pfam12685 471223006228 stage III sporulation protein AG; Region: spore_III_AG; TIGR02830 471223006229 stage III sporulation protein AF; Region: spore_III_AF; TIGR02896 471223006230 Stage III sporulation protein AF (Spore_III_AF); Region: Spore_III_AF; pfam09581 471223006231 Stage III sporulation protein AE (spore_III_AE); Region: Spore_III_AE; cl09771 471223006232 Stage III sporulation protein AC/AD protein family; Region: SpoIIIAC; cl05961 471223006233 Stage III sporulation protein AC/AD protein family; Region: SpoIIIAC; cl05961 471223006234 Stage III sporulation protein AB (spore_III_AB); Region: Spore_III_AB; cl08022 471223006235 stage III sporulation protein AA; Region: spore_III_AA; TIGR02858 471223006236 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 471223006237 Walker A motif; other site 471223006238 ATP binding site [chemical binding]; other site 471223006239 Walker B motif; other site 471223006240 Protein of unknown function (DUF2619); Region: DUF2619; pfam10942 471223006241 elongation factor P; Validated; Region: PRK00529 471223006242 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 471223006243 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 471223006244 RNA binding site [nucleotide binding]; other site 471223006245 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 471223006246 RNA binding site [nucleotide binding]; other site 471223006247 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 471223006248 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 471223006249 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 471223006250 active site 471223006251 Conserved membrane protein YqhR; Region: YqhR; pfam11085 471223006252 Protein of unknown function (DUF1385); Region: DUF1385; cl01595 471223006253 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 471223006254 ExoU and VipD-like proteins; homologus to patatin, cPLA2, and iPLA2; Region: Pat_ExoU_VipD_like; cd07207 471223006255 active site 471223006256 nucleophile elbow; other site 471223006257 manganese transport transcriptional regulator; Provisional; Region: PRK03902 471223006258 Helix-turn-helix domains; Region: HTH; cl00088 471223006259 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 471223006260 Protein of unknown function (DUF445); Region: DUF445; pfam04286 471223006261 Sodium:dicarboxylate symporter family; Region: SDF; cl00573 471223006262 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 471223006263 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 471223006264 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 471223006265 active site residue [active] 471223006266 Helix-turn-helix domains; Region: HTH; cl00088 471223006267 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 471223006268 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 471223006269 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 471223006270 transposase, putative, N-terminal domain; Region: tspaseT_teng_N; TIGR01765 471223006271 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 471223006272 Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282 471223006273 Glycine cleavage system protein P (pyridoxal-binding), C-terminal domain [Amino acid transport and metabolism]; Region: GcvP; COG1003 471223006274 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 471223006275 tetramer interface [polypeptide binding]; other site 471223006276 pyridoxal 5'-phosphate binding site [chemical binding]; other site 471223006277 catalytic residue [active] 471223006278 Glycine cleavage system protein P (pyridoxal-binding), N-terminal domain [Amino acid transport and metabolism]; Region: GcvP; COG0403 471223006279 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 471223006280 tetramer interface [polypeptide binding]; other site 471223006281 pyridoxal 5'-phosphate binding site [chemical binding]; other site 471223006282 catalytic residue [active] 471223006283 glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389 471223006284 Sarcosine oxidase, gamma subunit family; Region: SoxG; cl01893 471223006285 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 471223006286 SNF2 family N-terminal domain; Region: SNF2_N; pfam00176 471223006287 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 471223006288 ATP binding site [chemical binding]; other site 471223006289 putative Mg++ binding site [ion binding]; other site 471223006290 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 471223006291 nucleotide binding region [chemical binding]; other site 471223006292 ATP-binding site [chemical binding]; other site 471223006293 Bacterial protein YqhG of unknown function; Region: YqhG; pfam11079 471223006294 YqzE-like protein; Region: YqzE; pfam14038 471223006295 ComG operon protein 7; Region: ComGG; pfam14173 471223006296 Competence protein ComGF [Intracellular trafficking and secretion]; Region: ComGF; COG4940 471223006297 Verrucomicrobium spinosum paralogous family TIGR02596; Region: TIGR02596 471223006298 Competence protein ComGC [Intracellular trafficking and secretion]; Region: ComGC; COG4537 471223006299 Type II secretion system (T2SS), protein F; Region: T2SF; cl00906 471223006300 Type II secretion system (T2SS), protein F; Region: T2SF; cl00906 471223006301 Type II/IV secretion system protein; Region: T2SE; pfam00437 471223006302 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 471223006303 Walker A motif; other site 471223006304 ATP binding site [chemical binding]; other site 471223006305 Walker B motif; other site 471223006306 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 471223006307 putative DNA binding site [nucleotide binding]; other site 471223006308 Predicted transcriptional regulator [Transcription]; Region: COG2345 471223006309 putative Zn2+ binding site [ion binding]; other site 471223006310 Protein of unknown function (DUF2626); Region: DUF2626; pfam11117 471223006311 Uncharacterized conserved protein [Function unknown]; Region: COG1565 471223006312 Putative S-adenosyl-L-methionine-dependent methyltransferase; Region: Methyltransf_28; pfam02636 471223006313 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 471223006314 Protein of unknown function (DUF2759); Region: DUF2759; pfam10958 471223006315 Peptidase M14 carboxypeptidase family-like domain of Endopeptidase I; Region: M14_Endopeptidase_I; cd06229 471223006316 putative active site [active] 471223006317 Zn binding site [ion binding]; other site 471223006318 ROK family protein (putative glucokinase); Region: ROK_glcA_fam; TIGR00744 471223006319 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 471223006320 PyridoxaL 5'-Phosphate Dependent Enzymes class IV (PLPDE_IV). This D-amino acid superfamily, one of five classes of PLPDE, consists of branched-chain amino acid aminotransferases (BCAT), D-amino acid transferases (DAAT), and 4-amino-4-deoxychorismate...; Region: PLPDE_IV; cl00224 471223006321 Bacterial protein of unknown function (DUF910); Region: DUF910; cl11543 471223006322 Rhomboid family; Region: Rhomboid; cl11446 471223006323 Integral membrane protein DUF92; Region: DUF92; cl00793 471223006324 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; cl00360 471223006325 Ribosomal protein L33; Region: Ribosomal_L33; cl00383 471223006326 Ligand Binding Domain of Ephrin Receptors; Region: EphR_LBD; cl02704 471223006327 proteins similar to Escherichia coli yceG; Region: yceG_like; cl00675 471223006328 phosphate transporter ATP-binding protein; Provisional; Region: PRK14238 471223006329 Phosphate uptake is of fundamental importance in the cell physiology of bacteria because phosphate is required as a nutrient. The Pst system of E. coli comprises four distinct subunits encoded by the pstS, pstA, pstB, and pstC genes. The PstS protein...; Region: ABC_PstB_phosphate_transporter; cd03260 471223006330 Walker A/P-loop; other site 471223006331 ATP binding site [chemical binding]; other site 471223006332 Q-loop/lid; other site 471223006333 ABC transporter signature motif; other site 471223006334 Walker B; other site 471223006335 D-loop; other site 471223006336 H-loop/switch region; other site 471223006337 Transposase; Region: DEDD_Tnp_IS110; pfam01548 471223006338 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 471223006339 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 471223006340 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 471223006341 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 471223006342 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 471223006343 putative substrate translocation pore; other site 471223006344 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 471223006345 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 471223006346 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 471223006347 Protein of unknown function (DUF1189); Region: DUF1189; pfam06691 471223006348 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581 471223006349 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 471223006350 dimer interface [polypeptide binding]; other site 471223006351 conserved gate region; other site 471223006352 putative PBP binding loops; other site 471223006353 ABC-ATPase subunit interface; other site 471223006354 phosphate ABC transporter, permease protein PstC; Region: phosphate_pstC; TIGR02138 471223006355 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 471223006356 dimer interface [polypeptide binding]; other site 471223006357 conserved gate region; other site 471223006358 putative PBP binding loops; other site 471223006359 ABC-ATPase subunit interface; other site 471223006360 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 471223006361 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 471223006362 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cl00107 471223006363 putative peptidoglycan binding site; other site 471223006364 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366 471223006365 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 471223006366 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 471223006367 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 471223006368 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 471223006369 metal binding site 2 [ion binding]; metal-binding site 471223006370 putative DNA binding helix; other site 471223006371 metal binding site 1 [ion binding]; metal-binding site 471223006372 dimer interface [polypeptide binding]; other site 471223006373 structural Zn2+ binding site [ion binding]; other site 471223006374 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 471223006375 ABC-ATPase subunit interface; other site 471223006376 dimer interface [polypeptide binding]; other site 471223006377 putative PBP binding regions; other site 471223006378 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 471223006379 ABC component of the metal-type transporters. This family includes transporters involved in the uptake of various metallic cations such as iron, manganese, and zinc. The ATPases of this group of transporters are very similar to members of...; Region: ABC_Metallic_Cations; cd03235 471223006380 Protein of unknown function (DUF2624); Region: DUF2624; pfam11116 471223006381 endonuclease IV; Provisional; Region: PRK01060 471223006382 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019 471223006383 AP (apurinic/apyrimidinic) site pocket; other site 471223006384 DNA interaction; other site 471223006385 Metal-binding active site; metal-binding site 471223006386 ATP-dependent RNA helicase SrmB; Provisional; Region: PRK11192 471223006387 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 471223006388 ATP binding site [chemical binding]; other site 471223006389 Mg++ binding site [ion binding]; other site 471223006390 motif III; other site 471223006391 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 471223006392 nucleotide binding region [chemical binding]; other site 471223006393 ATP-binding site [chemical binding]; other site 471223006394 YqfQ-like protein; Region: YqfQ; pfam14181 471223006395 LytB protein; Region: LYTB; cl00507 471223006396 (E)-4-hydroxy-3-methyl-but-2-enyl pyrophosphate reductase (IPP and DMAPP forming); Region: ispH_lytB; TIGR00216 471223006397 NIF3 (NGG1p interacting factor 3); Region: NIF3; cl15371 471223006398 NIF3 (NGG1p interacting factor 3); Region: NIF3; cl15371 471223006399 NIF3 (NGG1p interacting factor 3); Region: NIF3; cl15371 471223006400 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 471223006401 Cytochrome c; Region: Cytochrom_C; cl11414 471223006402 RNA polymerase sigma factor RpoD; Validated; Region: PRK09210 471223006403 Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979 471223006404 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 471223006405 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 471223006406 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 471223006407 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 471223006408 DNA binding residues [nucleotide binding] 471223006409 DNA primase; Validated; Region: dnaG; PRK05667 471223006410 CHC2 zinc finger; Region: zf-CHC2; cl15369 471223006411 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 471223006412 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 471223006413 active site 471223006414 metal binding site [ion binding]; metal-binding site 471223006415 interdomain interaction site; other site 471223006416 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 471223006417 Uncharacterized BCR, YaiI/YqxD family COG1671; Region: DUF188; cl00727 471223006418 Kinase/pyrophosphorylase; Region: Kinase-PPPase; cl00780 471223006419 Helix-turn-helix domains; Region: HTH; cl00088 471223006420 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_4; cd04617 471223006421 FOG: CBS domain [General function prediction only]; Region: COG0517 471223006422 DNA repair protein RecO; Reviewed; Region: recO; PRK00085 471223006423 Recombination protein O N terminal; Region: RecO_N; cl15812 471223006424 Recombination protein O C terminal; Region: RecO_C; pfam02565 471223006425 YqzL-like protein; Region: YqzL; pfam14006 471223006426 GTPase Era; Reviewed; Region: era; PRK00089 471223006427 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 471223006428 G1 box; other site 471223006429 GTP/Mg2+ binding site [chemical binding]; other site 471223006430 Switch I region; other site 471223006431 G2 box; other site 471223006432 Switch II region; other site 471223006433 G3 box; other site 471223006434 G4 box; other site 471223006435 G5 box; other site 471223006436 K homology RNA-binding domain, type I. KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains that...; Region: KH-I; cl00098 471223006437 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 471223006438 active site 471223006439 catalytic motif [active] 471223006440 Zn binding site [ion binding]; other site 471223006441 Prokaryotic diacylglycerol kinase; Region: DAGK_prokar; cl00526 471223006442 Uncharacterized protein family UPF0054; Region: UPF0054; cl00402 471223006443 Predicted membrane-associated HD superfamily hydrolase [General function prediction only]; Region: COG1480 471223006444 7TM receptor with intracellular HD hydrolase; Region: 7TM-7TMR_HD; pfam07698 471223006445 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 471223006446 Zn2+ binding site [ion binding]; other site 471223006447 Mg2+ binding site [ion binding]; other site 471223006448 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 471223006449 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 471223006450 Putative stage IV sporulation protein YqfD; Region: YqfD; pfam06898 471223006451 sporulation protein YqfD; Region: spore_yqfD; TIGR02876 471223006452 YabP family; Region: YabP; cl06766 471223006453 GatB domain; Region: GatB_Yqey; cl11497 471223006454 Ribosomal protein S21; Region: Ribosomal_S21; cl00529 471223006455 Na/Pi-cotransporter; Region: NaPi_cotrn_rel; TIGR00704 471223006456 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 471223006457 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 471223006458 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 471223006459 intersubunit interface [polypeptide binding]; other site 471223006460 active site 471223006461 catalytic residue [active] 471223006462 radical SAM methylthiotransferase, MiaB/RimO family; Region: TIGR00089 471223006463 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 471223006464 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 471223006465 FeS/SAM binding site; other site 471223006466 TRAM domain; Region: TRAM; cl01282 471223006467 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1385; cl00611 471223006468 RNA methyltransferase; Region: Methyltrans_RNA; pfam04452 471223006469 Ribosomal protein L11 methyltransferase (PrmA); Region: PrmA; pfam06325 471223006470 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 471223006471 S-adenosylmethionine binding site [chemical binding]; other site 471223006472 chaperone protein DnaJ; Provisional; Region: PRK14280 471223006473 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 471223006474 HSP70 interaction site [polypeptide binding]; other site 471223006475 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262 471223006476 substrate binding site [polypeptide binding]; other site 471223006477 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 471223006478 Zn binding sites [ion binding]; other site 471223006479 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 471223006480 dimer interface [polypeptide binding]; other site 471223006481 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 471223006482 Actin; An ubiquitous protein involved in the formation of filaments that are a major component of the cytoskeleton. Interaction with myosin provides the basis of muscular contraction and many aspects of cell motility. Each actin protomer binds one...; Region: ACTIN; cl11528 471223006483 ATP binding site [chemical binding]; other site 471223006484 profilin binding site; other site 471223006485 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 471223006486 dimer interface [polypeptide binding]; other site 471223006487 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 471223006488 heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082 471223006489 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 471223006490 HrcA protein C terminal domain; Region: HrcA; pfam01628 471223006491 coproporphyrinogen III oxidase; Provisional; Region: PRK08599 471223006492 HemN C-terminal domain; Region: HemN_C; pfam06969 471223006493 GTP-binding protein LepA; Provisional; Region: PRK05433 471223006494 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 471223006495 G1 box; other site 471223006496 putative GEF interaction site [polypeptide binding]; other site 471223006497 GTP/Mg2+ binding site [chemical binding]; other site 471223006498 Switch I region; other site 471223006499 G2 box; other site 471223006500 G3 box; other site 471223006501 Switch II region; other site 471223006502 G4 box; other site 471223006503 G5 box; other site 471223006504 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 471223006505 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 471223006506 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 471223006507 Protein of unknown function (DUF3679); Region: DUF3679; pfam12438 471223006508 Stage II sporulation protein P (SpoIIP); Region: SpoIIP; pfam07454 471223006509 stage II sporulation protein P; Region: spore_II_P; TIGR02867 471223006510 Germination protease; Region: Peptidase_A25; cl04057 471223006511 Ribosomal protein S20; Region: Ribosomal_S20p; cl00384 471223006512 DNA polymerase III subunit delta; Reviewed; Region: holA; PRK05574 471223006513 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 471223006514 YqzM-like protein; Region: YqzM; pfam14141 471223006515 Domain of unknown function (DUF4131); Region: DUF4131; pfam13567 471223006516 DNA internalization-related competence protein ComEC/Rec2; Region: ComEC_Rec2; TIGR00361 471223006517 Competence protein; Region: Competence; cl00471 471223006518 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 471223006519 Deoxycytidylate deaminase domain. Deoxycytidylate deaminase catalyzes the deamination of dCMP to dUMP, providing the nucleotide substrate for thymidylate synthase. The enzyme binds Zn++, which is required for catalytic activity. The activity of the...; Region: deoxycytidylate_deaminase; cd01286 471223006520 catalytic motif [active] 471223006521 Zn binding site [ion binding]; other site 471223006522 SLBB domain; Region: SLBB; pfam10531 471223006523 comEA protein; Region: comE; TIGR01259 471223006524 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786 471223006525 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 471223006526 Pyrroline-5-carboxylate reductase [Amino acid transport and metabolism]; Region: ProC; COG0345 471223006527 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 471223006528 S-adenosylmethionine binding site [chemical binding]; other site 471223006529 Oligomerisation domain; Region: Oligomerisation; cl00519 471223006530 Predicted HD superfamily hydrolase involved in NAD metabolism [Coenzyme metabolism]; Region: COG1713 471223006531 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 471223006532 Zn2+ binding site [ion binding]; other site 471223006533 Mg2+ binding site [ion binding]; other site 471223006534 nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071 471223006535 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 471223006536 active site 471223006537 (T/H)XGH motif; other site 471223006538 CRS1 / YhbY (CRM) domain; Region: CRS1_YhbY; cl00663 471223006539 shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258 471223006540 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 471223006541 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 471223006542 shikimate binding site; other site 471223006543 NAD(P) binding site [chemical binding]; other site 471223006544 GTPase YqeH; Provisional; Region: PRK13796 471223006545 Circularly permuted YqeH GTPase; Region: YqeH; cd01855 471223006546 GTP/Mg2+ binding site [chemical binding]; other site 471223006547 G4 box; other site 471223006548 G5 box; other site 471223006549 G1 box; other site 471223006550 Switch I region; other site 471223006551 G2 box; other site 471223006552 G3 box; other site 471223006553 Switch II region; other site 471223006554 Predicted hydrolase of the HAD superfamily [General function prediction only]; Region: COG2179 471223006555 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 471223006556 active site 471223006557 motif I; other site 471223006558 motif II; other site 471223006559 Sporulation inhibitor A; Region: Sda; pfam08970 471223006560 Phosphatidylserine decarboxylase; Region: PS_Dcarbxylase; cl03656 471223006561 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 471223006562 flagellar motor protein MotA; Validated; Region: PRK08124 471223006563 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 471223006564 flagellar motor protein MotB; Reviewed; Region: motB; PRK07734 471223006565 Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677 471223006566 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 471223006567 ligand binding site [chemical binding]; other site 471223006568 pheromone autoinducer 2 transporter; Reviewed; Region: tqsA; cl00465 471223006569 Domain of unknown function DUF20; Region: UPF0118; pfam01594 471223006570 Bacitracin resistance protein BacA; Region: BacA; cl00858 471223006571 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 471223006572 Sodium:dicarboxylate symporter family; Region: SDF; cl00573 471223006573 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 471223006574 DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808 471223006575 sporulation sigma factor SigK; Reviewed; Region: PRK05803 471223006576 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 471223006577 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 471223006578 DNA binding residues [nucleotide binding] 471223006579 YrhC-like protein; Region: YrhC; pfam14143 471223006580 cystathionine beta-lyase; Provisional; Region: PRK07671 471223006581 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 471223006582 homodimer interface [polypeptide binding]; other site 471223006583 substrate-cofactor binding pocket; other site 471223006584 pyridoxal 5'-phosphate binding site [chemical binding]; other site 471223006585 catalytic residue [active] 471223006586 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 471223006587 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 471223006588 dimer interface [polypeptide binding]; other site 471223006589 pyridoxal 5'-phosphate binding site [chemical binding]; other site 471223006590 catalytic residue [active] 471223006591 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 471223006592 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 471223006593 S-adenosylmethionine binding site [chemical binding]; other site 471223006594 Protein of unknown function (DUF2536); Region: DUF2536; pfam10750 471223006595 Protein of unknown function (DUF1510); Region: DUF1510; pfam07423 471223006596 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 471223006597 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 471223006598 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 471223006599 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 471223006600 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 471223006601 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 471223006602 Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage pathway; Region: UMPK; cd02023 471223006603 Sugar specificity; other site 471223006604 Pyrimidine base specificity; other site 471223006605 ATP-binding site [chemical binding]; other site 471223006606 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 471223006607 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl09108 471223006608 Peptidase family U32; Region: Peptidase_U32; cl03113 471223006609 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl09108 471223006610 Peptidase family U32; Region: Peptidase_U32; cl03113 471223006611 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 471223006612 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 471223006613 S-adenosylmethionine binding site [chemical binding]; other site 471223006614 YceG-like family; Region: YceG; pfam02618 471223006615 proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010 471223006616 dimerization interface [polypeptide binding]; other site 471223006617 Protein of unknown function (DUF1292); Region: DUF1292; cl01608 471223006618 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD includes...; Region: RuvC_resolvase; cl00243 471223006619 Bacterial protein of unknown function (DUF965); Region: DUF965; cl01857 471223006620 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 471223006621 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent formation of...; Region: AlaRS_core; cd00673 471223006622 motif 1; other site 471223006623 active site 471223006624 motif 2; other site 471223006625 motif 3; other site 471223006626 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; cl08469 471223006627 DHHA1 domain; Region: DHHA1; pfam02272 471223006628 pheromone autoinducer 2 transporter; Reviewed; Region: tqsA; cl00465 471223006629 Protein of unknown function (DUF3918); Region: DUF3918; pfam13056 471223006630 Photosynthetic reaction center (RC) complex, subunit H; RC is an integral membrane protein-pigment complex which catalyzes light-induced reduction of ubiquinone to ubiquinol, generating a transmembrane electrochemical gradient of protons used to produce...; Region: PRCH; cl09959 471223006631 Photosynthetic reaction center (RC) complex, subunit H; RC is an integral membrane protein-pigment complex which catalyzes light-induced reduction of ubiquinone to ubiquinol, generating a transmembrane electrochemical gradient of protons used to produce...; Region: PRCH; cl09959 471223006632 helicase, putative, RecD/TraA family; Region: recD_rel; TIGR01448 471223006633 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 471223006634 Family description; Region: UvrD_C_2; cl15862 471223006635 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 471223006636 binding surface 471223006637 TPR motif; other site 471223006638 TPR repeat; Region: TPR_11; pfam13414 471223006639 TPR repeat; Region: TPR_11; pfam13414 471223006640 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 471223006641 binding surface 471223006642 TPR motif; other site 471223006643 TPR repeat; Region: TPR_11; pfam13414 471223006644 tRNA methyl transferase; Region: tRNA_Me_trans; pfam03054 471223006645 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 471223006646 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 471223006647 cysteine desulfurase DndA; Region: DNA_S_dndA; TIGR03235 471223006648 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 471223006649 catalytic residue [active] 471223006650 Predicted transcriptional regulator [Transcription]; Region: COG1959 471223006651 Helix-turn-helix domains; Region: HTH; cl00088 471223006652 Predicted membrane protein [Function unknown]; Region: COG2364 471223006653 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 471223006654 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 471223006655 recombination factor protein RarA; Reviewed; Region: PRK13342 471223006656 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 471223006657 Walker A motif; other site 471223006658 ATP binding site [chemical binding]; other site 471223006659 Walker B motif; other site 471223006660 arginine finger; other site 471223006661 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 471223006662 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 471223006663 Helix-turn-helix domains; Region: HTH; cl00088 471223006664 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 471223006665 Protein export membrane protein; Region: SecD_SecF; cl14618 471223006666 putative spore coat protein regulator protein YlbO; Provisional; Region: PRK13923 471223006667 transcription factor, RsfA family; Region: DNA_bind_RsfA; TIGR02894 471223006668 Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 1 [Coenzyme metabolism]; Region: COG1179 471223006669 Family of activating enzymes (E1) of ubiquitin-like proteins related to the E.coli hypothetical protein ygdL. The common reaction mechanism catalyzed by E1-like enzymes begins with a nucleophilic attack of the C-terminal carboxylate of the ubiquitin-like...; Region: YgdL_like; cd00755 471223006670 putative ATP binding site [chemical binding]; other site 471223006671 putative substrate interface [chemical binding]; other site 471223006672 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 471223006673 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 471223006674 dimer interface [polypeptide binding]; other site 471223006675 anticodon binding site; other site 471223006676 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of the...; Region: AspRS_core; cd00777 471223006677 homodimer interface [polypeptide binding]; other site 471223006678 motif 1; other site 471223006679 active site 471223006680 motif 2; other site 471223006681 GAD domain; Region: GAD; pfam02938 471223006682 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of the...; Region: AspRS_core; cd00777 471223006683 motif 3; other site 471223006684 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 471223006685 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: HisRS-like_core; cd00773 471223006686 dimer interface [polypeptide binding]; other site 471223006687 motif 1; other site 471223006688 active site 471223006689 motif 2; other site 471223006690 motif 3; other site 471223006691 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 471223006692 anticodon binding site; other site 471223006693 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563 471223006694 putative active site [active] 471223006695 dimerization interface [polypeptide binding]; other site 471223006696 putative tRNAtyr binding site [nucleotide binding]; other site 471223006697 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 471223006698 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 471223006699 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 471223006700 synthetase active site [active] 471223006701 NTP binding site [chemical binding]; other site 471223006702 metal binding site [ion binding]; metal-binding site 471223006703 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 471223006704 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 471223006705 Adenine/guanine phosphoribosyltransferases and related PRPP-binding proteins [Nucleotide transport and metabolism]; Region: Apt; COG0503 471223006706 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 471223006707 active site 471223006708 single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644 471223006709 DHH family; Region: DHH; pfam01368 471223006710 DHHA1 domain; Region: DHHA1; pfam02272 471223006711 Single-strand DNA-specific exonuclease, C terminal domain; Region: ssDNA-exonuc_C; cl11538 471223006712 bifunctional preprotein translocase subunit SecD/SecF; Reviewed; Region: PRK13024 471223006713 SecD/SecF GG Motif; Region: Sec_GG; pfam07549 471223006714 Protein export membrane protein; Region: SecD_SecF; cl14618 471223006715 SecD/SecF GG Motif; Region: Sec_GG; pfam07549 471223006716 Protein export membrane protein; Region: SecD_SecF; cl14618 471223006717 Post-transcriptional regulator; Region: Post_transc_reg; pfam13797 471223006718 stage V sporulation protein B; Region: spore_V_B; TIGR02900 471223006719 MatE; Region: MatE; cl10513 471223006720 Protein of unknown function (DUF3792); Region: DUF3792; cl14821 471223006721 Preprotein translocase subunit; Region: YajC; cl00806 471223006722 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; cl00409 471223006723 tRNA-guanine transglycosylases, various specificities; Region: tgt_general; TIGR00449 471223006724 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147 471223006725 Queuosine biosynthesis protein; Region: Queuosine_synth; cl00523 471223006726 Protein of unknown function (DUF2905); Region: DUF2905; pfam11146 471223006727 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 471223006728 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 471223006729 Walker A motif; other site 471223006730 ATP binding site [chemical binding]; other site 471223006731 Walker B motif; other site 471223006732 arginine finger; other site 471223006733 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 471223006734 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 471223006735 RuvA N terminal domain; Region: RuvA_N; pfam01330 471223006736 RuvA, C-terminal domain; Region: RuvA_C; pfam07499 471223006737 Bypass of Forespore C, N terminal; Region: BOFC_N; pfam08977 471223006738 BofC C-terminal domain; Region: BofC_C; pfam08955 471223006739 Transcriptional regulator; Region: Transcrip_reg; cl00361 471223006740 Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ); Region: Spore_YhcN_YlaJ; pfam09580 471223006741 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 471223006742 NAD synthase; Region: NAD_synthase; pfam02540 471223006743 homodimer interface [polypeptide binding]; other site 471223006744 NAD binding pocket [chemical binding]; other site 471223006745 ATP binding pocket [chemical binding]; other site 471223006746 Mg binding site [ion binding]; other site 471223006747 active-site loop [active] 471223006748 Phosphotransferase enzyme family; Region: APH; pfam01636 471223006749 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 471223006750 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 471223006751 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118 471223006752 putative peptidoglycan binding site; other site 471223006753 Quinolinate synthetase A protein; Region: NadA; cl00420 471223006754 nicotinate-nucleotide pyrophosphorylase; Provisional; Region: PRK08072 471223006755 Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572 471223006756 dimerization interface [polypeptide binding]; other site 471223006757 active site 471223006758 L-aspartate oxidase; Provisional; Region: PRK08071 471223006759 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 471223006760 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 471223006761 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 471223006762 cysteine desulfurase DndA; Region: DNA_S_dndA; TIGR03235 471223006763 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 471223006764 catalytic residue [active] 471223006765 Predicted small molecule binding protein (contains 3H domain) [General function prediction only]; Region: COG1827 471223006766 Helix-turn-helix domains; Region: HTH; cl00088 471223006767 3H domain; Region: 3H; pfam02829 471223006768 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_18; cd04677 471223006769 nudix motif; other site 471223006770 prephenate dehydratase; Provisional; Region: PRK11898 471223006771 Prephenate dehydratase; Region: PDT; pfam00800 471223006772 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 471223006773 putative L-Phe binding site [chemical binding]; other site 471223006774 hypothetical protein; Provisional; Region: PRK04435 471223006775 C-terminal ACT domain of a small (; 147 a.a.) putative phenylalanine biosynthetic pathway protein described in Bacillus subtilis (BS) PheB (PheB-BS) and related domains; Region: ACT_PheB-BS; cd04888 471223006776 GTPase CgtA; Reviewed; Region: obgE; PRK12297 471223006777 GTP1/OBG; Region: GTP1_OBG; pfam01018 471223006778 Obg GTPase; Region: Obg; cd01898 471223006779 G1 box; other site 471223006780 GTP/Mg2+ binding site [chemical binding]; other site 471223006781 Switch I region; other site 471223006782 G2 box; other site 471223006783 G3 box; other site 471223006784 Switch II region; other site 471223006785 G4 box; other site 471223006786 G5 box; other site 471223006787 Domain of unknown function (DUF1967); Region: DUF1967; cl07779 471223006788 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 471223006789 Probable transposase; Region: OrfB_IS605; pfam01385 471223006790 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 471223006791 Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282 471223006792 Ribosomal L27 protein; Region: Ribosomal_L27; cl00359 471223006793 Protein of unknown function (DUF464); Region: DUF464; cl01080 471223006794 Ribosomal prokaryotic L21 protein; Region: Ribosomal_L21p; cl00382 471223006795 SpoIVFB Site-2 protease (S2P), a zinc metalloprotease (MEROPS family M50B), regulates intramembrane proteolysis (RIP), and is involved in the pro-sigmaK pathway of bacterial spore formation. SpoIVFB (sporulation protein, stage IV cell wall formation, F...; Region: S2P-M50_SpoIVFB; cd06161 471223006796 active site 471223006797 putative substrate binding region [chemical binding]; other site 471223006798 Peptidase family M23; Region: Peptidase_M23; pfam01551 471223006799 septum site-determining protein MinD; Region: minD_bact; TIGR01968 471223006800 Bacterial cell division requires the formation of a septum at mid-cell. The site is determined by the min operon products MinC, MinD and MinE. MinC is a nonspecific inhibitor of the septum protein FtsZ. MinE is the supressor of MinC. MinD plays a pivotal...; Region: MinD; cd02036 471223006801 P-loop; other site 471223006802 ADP binding residues [chemical binding]; other site 471223006803 Switch I; other site 471223006804 Switch II; other site 471223006805 septum formation inhibitor; Reviewed; Region: minC; PRK00513 471223006806 Septum formation inhibitor MinC, C-terminal domain; Region: MinC_C; pfam03775 471223006807 rod shape-determining protein MreD; Region: MreD; cl01087 471223006808 rod shape-determining protein MreC; Provisional; Region: PRK13922 471223006809 rod shape-determining protein MreC; Region: MreC; pfam04085 471223006810 rod shape-determining protein MreB; Provisional; Region: PRK13927 471223006811 Cell division protein FtsA; Region: FtsA; cl11496 471223006812 hypothetical protein; Reviewed; Region: PRK00024 471223006813 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 471223006814 MPN+ (JAMM) motif; other site 471223006815 Zinc-binding site [ion binding]; other site 471223006816 Maf-like protein; Region: Maf; pfam02545 471223006817 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 471223006818 active site 471223006819 dimer interface [polypeptide binding]; other site 471223006820 Tfp pilus assembly protein, ATPase PilM [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilM; COG4972 471223006821 Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989 471223006822 Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750 471223006823 Type IV leader peptidase family; Region: Peptidase_A24; cl02077 471223006824 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 471223006825 Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459 471223006826 Type II secretion system (T2SS), protein F; Region: T2SF; cl00906 471223006827 Type II secretion system (T2SS), protein F; Region: T2SF; cl00906 471223006828 pilus retraction protein PilT; Region: pilT_fam; TIGR01420 471223006829 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 471223006830 Walker A motif; other site 471223006831 ATP binding site [chemical binding]; other site 471223006832 Walker B motif; other site 471223006833 type IV-A pilus assembly ATPase PilB; Region: type_IV_pilB; TIGR02538 471223006834 Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157 471223006835 PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129 471223006836 Walker A motif; other site 471223006837 ATP binding site [chemical binding]; other site 471223006838 Walker B motif; other site 471223006839 VanW like protein; Region: VanW; pfam04294 471223006840 YqfQ-like protein; Region: YqfQ; pfam14181 471223006841 PRC-barrel domain containing protein [General function prediction only]; Region: COG3881 471223006842 Photosynthetic reaction center (RC) complex, subunit H; RC is an integral membrane protein-pigment complex which catalyzes light-induced reduction of ubiquinone to ubiquinol, generating a transmembrane electrochemical gradient of protons used to produce...; Region: PRCH; cl09959 471223006843 AAA ATPase containing von Willebrand factor type A (vWA) domain [General function prediction only]; Region: MDN1; COG5271 471223006844 Type II secretory pathway, component PulJ [Intracellular trafficking and secretion]; Region: PulJ; COG4795 471223006845 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; cl06830 471223006846 Helix-turn-helix domains; Region: HTH; cl00088 471223006847 Winged helix-turn helix; Region: HTH_29; pfam13551 471223006848 Helix-turn-helix domains; Region: HTH; cl00088 471223006849 Winged helix-turn helix; Region: HTH_33; pfam13592 471223006850 Integrase core domain; Region: rve; cl01316 471223006851 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 471223006852 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 471223006853 metal ion-dependent adhesion site (MIDAS); other site 471223006854 flagellar hook protein FlgE; Provisional; Region: flgE; PRK12637 471223006855 Bacterial Ig-like domain (group 2); Region: Big_2; cl02708 471223006856 folylpolyglutamate synthase/dihydrofolate synthase; Region: folC; TIGR01499 471223006857 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 471223006858 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 471223006859 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 471223006860 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 471223006861 active site 471223006862 HIGH motif; other site 471223006863 nucleotide binding site [chemical binding]; other site 471223006864 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 471223006865 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 471223006866 active site 471223006867 KMSKS motif; other site 471223006868 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 471223006869 tRNA binding surface [nucleotide binding]; other site 471223006870 anticodon binding site; other site 471223006871 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 471223006872 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 471223006873 spore coat protein, CotS family; Region: spore_CotS; TIGR02906 471223006874 stage VI sporulation protein D; Region: spore_VI_D; TIGR02907 471223006875 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118 471223006876 putative peptidoglycan binding site; other site 471223006877 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062 471223006878 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 471223006879 inhibitor-cofactor binding pocket; inhibition site 471223006880 pyridoxal 5'-phosphate binding site [chemical binding]; other site 471223006881 catalytic residue [active] 471223006882 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cd00384 471223006883 dimer interface [polypeptide binding]; other site 471223006884 active site 471223006885 Schiff base residues; other site 471223006886 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 471223006887 active site 471223006888 Uroporphyrinogen-III synthase HemD; Region: HEM4; pfam02602 471223006889 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 471223006890 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cd00494 471223006891 domain interfaces; other site 471223006892 active site 471223006893 Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504 471223006894 glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045 471223006895 NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213 471223006896 tRNA; other site 471223006897 putative tRNA binding site [nucleotide binding]; other site 471223006898 putative NADP binding site [chemical binding]; other site 471223006899 Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745 471223006900 Predicted GTPase [General function prediction only]; Region: COG0218 471223006901 YihA (EngB) GTPase family; Region: YihA_EngB; cd01876 471223006902 G1 box; other site 471223006903 GTP/Mg2+ binding site [chemical binding]; other site 471223006904 Switch I region; other site 471223006905 G2 box; other site 471223006906 G3 box; other site 471223006907 Switch II region; other site 471223006908 G4 box; other site 471223006909 G5 box; other site 471223006910 ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466 471223006911 Found in ATP-dependent protease La (LON); Region: LON; smart00464 471223006912 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 471223006913 Walker A motif; other site 471223006914 ATP binding site [chemical binding]; other site 471223006915 Walker B motif; other site 471223006916 arginine finger; other site 471223006917 Subunit ChlI of Mg-chelatase; Region: ChlI; cl12214 471223006918 ATP-dependent protease LonB; Region: spore_lonB; TIGR02902 471223006919 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 471223006920 Walker A motif; other site 471223006921 ATP binding site [chemical binding]; other site 471223006922 Walker B motif; other site 471223006923 arginine finger; other site 471223006924 Subunit ChlI of Mg-chelatase; Region: ChlI; cl12214 471223006925 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 471223006926 ClpX C4-type zinc finger; Region: zf-C4_ClpX; cl05964 471223006927 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 471223006928 Walker A motif; other site 471223006929 ATP binding site [chemical binding]; other site 471223006930 Walker B motif; other site 471223006931 arginine finger; other site 471223006932 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; cl11083 471223006933 trigger factor; Provisional; Region: tig; PRK01490 471223006934 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; cl11587 471223006935 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 471223006936 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 471223006937 binding surface 471223006938 Tetratricopeptide repeat; Region: TPR_16; pfam13432 471223006939 TPR motif; other site 471223006940 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 471223006941 substrate binding site [chemical binding]; other site 471223006942 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 471223006943 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 471223006944 substrate binding site [chemical binding]; other site 471223006945 ligand binding site [chemical binding]; other site 471223006946 tartrate dehydrogenase; Provisional; Region: PRK08194 471223006947 Isocitrate/isopropylmalate dehydrogenase; Region: Iso_dh; cl00445 471223006948 2-isopropylmalate synthase; Validated; Region: PRK00915 471223006949 2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940 471223006950 active site 471223006951 catalytic residues [active] 471223006952 metal binding site [ion binding]; metal-binding site 471223006953 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; cl07212 471223006954 ketol-acid reductoisomerase; Provisional; Region: PRK05479 471223006955 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 471223006956 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 471223006957 acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895 471223006958 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 471223006959 putative valine binding site [chemical binding]; other site 471223006960 dimer interface [polypeptide binding]; other site 471223006961 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 471223006962 acetolactate synthase catalytic subunit; Reviewed; Region: PRK07710 471223006963 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 471223006964 PYR/PP interface [polypeptide binding]; other site 471223006965 dimer interface [polypeptide binding]; other site 471223006966 TPP binding site [chemical binding]; other site 471223006967 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; cl00815 471223006968 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 471223006969 TPP-binding site [chemical binding]; other site 471223006970 dimer interface [polypeptide binding]; other site 471223006971 D-Alanine aminotransferase (D-AAT_like): D-amino acid aminotransferase catalyzes transamination between D-amino acids and their respective alpha-keto acids. It plays a major role in the synthesis of bacterial cell wall components like D-alanine and...; Region: D-AAT_like; cd01558 471223006972 homodimer interface [polypeptide binding]; other site 471223006973 substrate-cofactor binding pocket; other site 471223006974 pyridoxal 5'-phosphate binding site [chemical binding]; other site 471223006975 catalytic residue [active] 471223006976 Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841 471223006977 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 471223006978 active site 471223006979 metal binding site [ion binding]; metal-binding site 471223006980 homotetramer interface [polypeptide binding]; other site 471223006981 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 471223006982 active site 471223006983 dimerization interface [polypeptide binding]; other site 471223006984 ribonuclease PH; Reviewed; Region: rph; PRK00173 471223006985 Ribonuclease PH; Region: RNase_PH_bact; cd11362 471223006986 hexamer interface [polypeptide binding]; other site 471223006987 active site 471223006988 Sporulation and spore germination; Region: Germane; cl11253 471223006989 Spore germination protein [General function prediction only]; Region: COG5401 471223006990 Sporulation and spore germination; Region: Germane; cl11253 471223006991 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 471223006992 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 471223006993 DNA binding residues [nucleotide binding] 471223006994 dimerization interface [polypeptide binding]; other site 471223006995 succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK08640 471223006996 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cl00159 471223006997 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 471223006998 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK08641 471223006999 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 471223007000 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 471223007001 Succinate:quinone oxidoreductase (SQR) Type B subfamily 1, transmembrane subunit; composed of proteins similar to Bacillus subtilis SQR. SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. Bacillus subtilis...; Region: SQR_TypeB_1_TM; cd03497 471223007002 putative Iron-sulfur protein interface [polypeptide binding]; other site 471223007003 succinate dehydrogenase (or fumarate reductase) cytochrome b subunit, b558 family; Region: sdhC_b558_fam; TIGR02046 471223007004 proximal heme binding site [chemical binding]; other site 471223007005 distal heme binding site [chemical binding]; other site 471223007006 putative dimer interface [polypeptide binding]; other site 471223007007 Protein of unknown function (DUF2507); Region: DUF2507; pfam10702 471223007008 aspartate kinase; Reviewed; Region: PRK06635 471223007009 AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261 471223007010 putative nucleotide binding site [chemical binding]; other site 471223007011 putative catalytic residues [active] 471223007012 putative Mg ion binding site [ion binding]; other site 471223007013 putative aspartate binding site [chemical binding]; other site 471223007014 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913 471223007015 putative allosteric regulatory site; other site 471223007016 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AK-LysC-DapG-like_2; cd04923 471223007017 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 471223007018 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 471223007019 GIY-YIG motif/motif A; other site 471223007020 active site 471223007021 catalytic site [active] 471223007022 putative DNA binding site [nucleotide binding]; other site 471223007023 metal binding site [ion binding]; metal-binding site 471223007024 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 471223007025 H3TH domains of structure-specific 5' nucleases (or flap endonuclease-1-like) involved in DNA replication, repair, and recombination; Region: H3TH_StructSpec-5'-nucleases; cl14815 471223007026 Iron permease FTR1 family; Region: FTR1; cl00475 471223007027 Imelysin; Region: Peptidase_M75; cl09159 471223007028 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 471223007029 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 471223007030 Ligand binding site; other site 471223007031 Putative Catalytic site; other site 471223007032 DXD motif; other site 471223007033 Sulfatase; Region: Sulfatase; cl10460 471223007034 Uncharacterized protein family (UPF0104); Region: UPF0104; cl04219 471223007035 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 471223007036 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 471223007037 NAD(P) binding site [chemical binding]; other site 471223007038 active site 471223007039 alkanesulfonate monooxygenase; Provisional; Region: PRK00719 471223007040 Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094 471223007041 active site 471223007042 dimer interface [polypeptide binding]; other site 471223007043 non-prolyl cis peptide bond; other site 471223007044 insertion regions; other site 471223007045 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 471223007046 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 471223007047 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 471223007048 dimer interface [polypeptide binding]; other site 471223007049 conserved gate region; other site 471223007050 putative PBP binding loops; other site 471223007051 ABC-ATPase subunit interface; other site 471223007052 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 471223007053 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 471223007054 substrate binding pocket [chemical binding]; other site 471223007055 membrane-bound complex binding site; other site 471223007056 hinge residues; other site 471223007057 NrtD and SsuB are the ATP-binding subunits of the bacterial ABC-type nitrate and sulfonate transport systems, respectively. ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars; Region: ABC_NrtD_SsuB_transporters; cd03293 471223007058 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 471223007059 Walker A/P-loop; other site 471223007060 ATP binding site [chemical binding]; other site 471223007061 Q-loop/lid; other site 471223007062 ABC transporter signature motif; other site 471223007063 Walker B; other site 471223007064 D-loop; other site 471223007065 H-loop/switch region; other site 471223007066 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 471223007067 catalytic residues [active] 471223007068 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 471223007069 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715 471223007070 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 471223007071 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 471223007072 Ligand binding site [chemical binding]; other site 471223007073 Electron transfer flavoprotein domain; Region: ETF; pfam01012 471223007074 enoyl-CoA hydratase; Provisional; Region: PRK07658 471223007075 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 471223007076 substrate binding site [chemical binding]; other site 471223007077 oxyanion hole (OAH) forming residues; other site 471223007078 trimer interface [polypeptide binding]; other site 471223007079 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 471223007080 Helix-turn-helix domains; Region: HTH; cl00088 471223007081 YsiA-like protein, C-terminal region; Region: TetR_C_4; pfam08359 471223007082 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06710 471223007083 AMP-binding enzyme; Region: AMP-binding; cl15778 471223007084 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 471223007085 Predicted membrane protein [Function unknown]; Region: COG3766 471223007086 Domain of Unknown Function (DUF350); Region: DUF350; pfam03994 471223007087 Domain of Unknown Function (DUF350); Region: DUF350; pfam03994 471223007088 recombination and DNA strand exchange inhibitor protein; Reviewed; Region: PRK00409 471223007089 MutS2 homologs in bacteria and eukaryotes. The MutS protein initiates DNA mismatch repair by recognizing mispaired and unpaired bases embedded in duplex DNA and activating endo- and exonucleases to remove the mismatch. Members of the MutS family also...; Region: ABC_MutS2; cd03280 471223007090 Walker A/P-loop; other site 471223007091 ATP binding site [chemical binding]; other site 471223007092 Q-loop/lid; other site 471223007093 ABC transporter signature motif; other site 471223007094 Walker B; other site 471223007095 D-loop; other site 471223007096 H-loop/switch region; other site 471223007097 Plant ATP synthase F0; Region: YMF19; cl07975 471223007098 Smr domain; Region: Smr; cl02619 471223007099 hypothetical protein; Provisional; Region: PRK08609 471223007100 Nucleotidyltransferase (NT) domain of family X DNA Polymerases; Region: NT_POLXc; cd00141 471223007101 active site 471223007102 primer binding site [nucleotide binding]; other site 471223007103 NTP binding site [chemical binding]; other site 471223007104 metal binding triad [ion binding]; metal-binding site 471223007105 Colicin V production protein; Region: Colicin_V; cl00567 471223007106 Cell division protein ZapA; Region: ZapA; cl01146 471223007107 ribonuclease HIII; Provisional; Region: PRK00996 471223007108 Domain of unknown function (DUF3378); Region: DUF3378; pfam11858 471223007109 bacterial Ribonuclease HIII-like; Region: RNase_HII_bacteria_HIII_like; cd06590 471223007110 RNA/DNA hybrid binding site [nucleotide binding]; other site 471223007111 active site 471223007112 Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693 471223007113 Type 1 glutamine amidotransferase (GATase1)-like domain found in proteins similar to Escherichia coli Hsp31 protein; Region: GATase1_Hsp31_like; cd03141 471223007114 potential catalytic triad [active] 471223007115 conserved cys residue [active] 471223007116 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 471223007117 Predicted membrane protein [Function unknown]; Region: COG1511 471223007118 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 471223007119 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 471223007120 Helix-turn-helix domains; Region: HTH; cl00088 471223007121 Nucleotidyl transferase of unknown function (DUF2204); Region: DUF2204; pfam09970 471223007122 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 471223007123 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 471223007124 Walker A/P-loop; other site 471223007125 ATP binding site [chemical binding]; other site 471223007126 Q-loop/lid; other site 471223007127 ABC transporter signature motif; other site 471223007128 Walker B; other site 471223007129 D-loop; other site 471223007130 H-loop/switch region; other site 471223007131 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 471223007132 This family of ATP-binding proteins belongs to a multisubunit transporter involved in drug resistance (BcrA and DrrA), nodulation, lipid transport, and lantibiotic immunity. In bacteria and archaea, these transporters usually include an ATP-binding...; Region: ABC_DR_subfamily_A; cd03230 471223007133 Walker A/P-loop; other site 471223007134 ATP binding site [chemical binding]; other site 471223007135 Q-loop/lid; other site 471223007136 ABC transporter signature motif; other site 471223007137 Walker B; other site 471223007138 D-loop; other site 471223007139 H-loop/switch region; other site 471223007140 Predicted transcriptional regulators [Transcription]; Region: COG1725 471223007141 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 471223007142 DNA-binding site [nucleotide binding]; DNA binding site 471223007143 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 471223007144 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 471223007145 putative tRNA-binding site [nucleotide binding]; other site 471223007146 B3/4 domain; Region: B3_4; cl11458 471223007147 tRNA synthetase B5 domain; Region: B5; cl08394 471223007148 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 471223007149 dimer interface [polypeptide binding]; other site 471223007150 motif 1; other site 471223007151 motif 3; other site 471223007152 motif 2; other site 471223007153 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; cl08386 471223007154 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 471223007155 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 471223007156 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 471223007157 dimer interface [polypeptide binding]; other site 471223007158 motif 1; other site 471223007159 active site 471223007160 motif 2; other site 471223007161 motif 3; other site 471223007162 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 471223007163 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; cl06870 471223007164 SpoU rRNA Methylase family; Region: SpoU_methylase; cl00362 471223007165 Peptide methionine sulfoxide reductase; Region: PMSR; cl00366 471223007166 Small, acid-soluble spore protein I; Region: SSPI; cl07940 471223007167 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 471223007168 transposase, putative, N-terminal domain; Region: tspaseT_teng_N; TIGR01765 471223007169 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 471223007170 Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282 471223007171 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 471223007172 M42 Peptidase, Endoglucanases; Region: M42_Frv; cd05656 471223007173 oligomer interface [polypeptide binding]; other site 471223007174 active site 471223007175 metal binding site [ion binding]; metal-binding site 471223007176 Dimeric dUTPase [Carbohydrate transport and metabolism]; Region: COG4508 471223007177 dUTPase; Region: dUTPase_2; pfam08761 471223007178 Protein of unknown function (DUF1294); Region: DUF1294; cl01311 471223007179 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 471223007180 23S rRNA binding site [nucleotide binding]; other site 471223007181 L21 binding site [polypeptide binding]; other site 471223007182 L13 binding site [polypeptide binding]; other site 471223007183 Ribosomal protein L35; Region: Ribosomal_L35p; cl00392 471223007184 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 471223007185 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 471223007186 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 471223007187 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413 471223007188 TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667 471223007189 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; cl08469 471223007190 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 471223007191 active site 471223007192 dimer interface [polypeptide binding]; other site 471223007193 motif 1; other site 471223007194 motif 2; other site 471223007195 motif 3; other site 471223007196 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 471223007197 anticodon binding site; other site 471223007198 YtxC-like family; Region: YtxC; cl08500 471223007199 primosomal protein DnaI; Reviewed; Region: PRK08939 471223007200 Primosomal protein DnaI N-terminus; Region: DnaI_N; pfam07319 471223007201 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 471223007202 Walker A motif; other site 471223007203 ATP binding site [chemical binding]; other site 471223007204 Walker B motif; other site 471223007205 Replication initiation/membrane attachment protein [DNA replication, recombination, and repair]; Region: DnaB; COG3611 471223007206 Replication initiation and membrane attachment; Region: DnaB_2; cl12121 471223007207 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 471223007208 ATP cone domain; Region: ATP-cone; pfam03477 471223007209 Transposase domain (DUF772); Region: DUF772; cl15789 471223007210 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 471223007211 S-adenosylmethionine decarboxylase; Region: AdoMet_dc; cl00687 471223007212 glyceraldehyde-3-phosphate dehydrogenase; Validated; Region: PRK07729 471223007213 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 471223007214 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; cl15856 471223007215 dephospho-CoA kinase; Region: TIGR00152 471223007216 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 471223007217 CoA-binding site [chemical binding]; other site 471223007218 ATP-binding [chemical binding]; other site 471223007219 formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103 471223007220 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 471223007221 DNA binding site [nucleotide binding] 471223007222 catalytic residue [active] 471223007223 H2TH interface [polypeptide binding]; other site 471223007224 putative catalytic residues [active] 471223007225 turnover-facilitating residue; other site 471223007226 intercalation triad [nucleotide binding]; other site 471223007227 8OG recognition residue [nucleotide binding]; other site 471223007228 putative reading head residues; other site 471223007229 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 471223007230 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 471223007231 DNA polymerase I; Provisional; Region: PRK05755 471223007232 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 471223007233 active site 471223007234 metal binding site 1 [ion binding]; metal-binding site 471223007235 putative 5' ssDNA interaction site; other site 471223007236 metal binding site 3; metal-binding site 471223007237 metal binding site 2 [ion binding]; metal-binding site 471223007238 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 471223007239 putative DNA binding site [nucleotide binding]; other site 471223007240 putative metal binding site [ion binding]; other site 471223007241 inactive DEDDy 3'-5' exonuclease domain of Bacillus stearothermophilus DNA polymerase I and similar family-A DNA polymerases; Region: DNA_polA_I_Bacillus_like_exo; cd06140 471223007242 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 471223007243 active site 471223007244 DNA binding site [nucleotide binding] 471223007245 catalytic site [active] 471223007246 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 471223007247 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 471223007248 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 471223007249 putative active site [active] 471223007250 heme pocket [chemical binding]; other site 471223007251 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 471223007252 dimer interface [polypeptide binding]; other site 471223007253 phosphorylation site [posttranslational modification] 471223007254 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 471223007255 ATP binding site [chemical binding]; other site 471223007256 Mg2+ binding site [ion binding]; other site 471223007257 G-X-G motif; other site 471223007258 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 471223007259 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 471223007260 active site 471223007261 phosphorylation site [posttranslational modification] 471223007262 intermolecular recognition site; other site 471223007263 dimerization interface [polypeptide binding]; other site 471223007264 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 471223007265 DNA binding site [nucleotide binding] 471223007266 (R)-hydratase [(R)-specific enoyl-CoA hydratase] catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. (R)-hydratase contains a hot-dog fold similar to those of thioesterase...; Region: R_hydratase; cd03449 471223007267 dimer interaction site [polypeptide binding]; other site 471223007268 substrate-binding tunnel; other site 471223007269 active site 471223007270 catalytic site [active] 471223007271 substrate binding site [chemical binding]; other site 471223007272 malate dehydrogenase; Reviewed; Region: PRK06223 471223007273 L-lactate dehydrogenase-like malate dehydrogenase proteins; Region: LDH-like_MDH; cd01339 471223007274 NAD(P) binding site [chemical binding]; other site 471223007275 dimer interface [polypeptide binding]; other site 471223007276 tetramer (dimer of dimers) interface [polypeptide binding]; other site 471223007277 substrate binding site [chemical binding]; other site 471223007278 Isocitrate/isopropylmalate dehydrogenase; Region: Iso_dh; cl00445 471223007279 isocitrate dehydrogenase; Validated; Region: PRK07362 471223007280 Bacillus subtilis (Bs) citrate synthase (CS)-II_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). 2MCS catalyzes the...; Region: BSuCS-II_like; cd06110 471223007281 dimer interface [polypeptide binding]; other site 471223007282 Citrate synthase; Region: Citrate_synt; pfam00285 471223007283 active site 471223007284 citrylCoA binding site [chemical binding]; other site 471223007285 oxalacetate/citrate binding site [chemical binding]; other site 471223007286 coenzyme A binding site [chemical binding]; other site 471223007287 catalytic triad [active] 471223007288 Protein of unknown function (DUF441); Region: DUF441; cl01041 471223007289 DDE superfamily endonuclease; Region: DDE_5; cl02413 471223007290 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 471223007291 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 471223007292 transposase, putative, N-terminal domain; Region: tspaseT_teng_N; TIGR01765 471223007293 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 471223007294 Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282 471223007295 pheromone autoinducer 2 transporter; Reviewed; Region: tqsA; cl00465 471223007296 Domain of unknown function DUF20; Region: UPF0118; pfam01594 471223007297 FxsA cytoplasmic membrane protein; Region: FxsA; cl01148 471223007298 pyruvate kinase; Provisional; Region: PRK06354 471223007299 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cd00288 471223007300 domain interfaces; other site 471223007301 active site 471223007302 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; cl01586 471223007303 Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to a subfamily of the PFKA family (cd00363) and include bacterial ATP-dependent...; Region: Bacterial_PFK; cd00763 471223007304 active site 471223007305 ADP/pyrophosphate binding site [chemical binding]; other site 471223007306 dimerization interface [polypeptide binding]; other site 471223007307 allosteric effector site; other site 471223007308 fructose-1,6-bisphosphate binding site; other site 471223007309 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl15772 471223007310 acetyl-CoA carboxylase carboxyltransferase alpha subunit; Provisional; Region: accA; CHL00198 471223007311 acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654 471223007312 RNA polymerases M/15 Kd subunit; Region: RNA_POL_M_15KD; cl02717 471223007313 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl15772 471223007314 DNA polymerase III DnaE; Reviewed; Region: dnaE; PRK06920 471223007315 Bacterial DNA polymerase III alpha subunit; Region: DNA_pol3_alpha; pfam07733 471223007316 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 471223007317 generic binding surface II; other site 471223007318 generic binding surface I; other site 471223007319 Sporulation protein YtrH; Region: Spore_YtrH; pfam14034 471223007320 Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618 471223007321 DHH family; Region: DHH; pfam01368 471223007322 DHHA1 domain; Region: DHHA1; pfam02272 471223007323 YtpI-like protein; Region: YtpI; pfam14007 471223007324 Predicted transcriptional regulator containing CBS domains [Transcription]; Region: COG4109 471223007325 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 471223007326 DNA-binding site [nucleotide binding]; DNA binding site 471223007327 DRTGG domain; Region: DRTGG; cl12147 471223007328 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with a DRTGG domain upstream. The function of the DRTGG domain, named after its conserved residues, is unknown. CBS is a small domain originally...; Region: CBS_pair_DRTGG_assoc; cd04596 471223007329 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 471223007330 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 471223007331 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 471223007332 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 471223007333 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 471223007334 active site 471223007335 Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686 471223007336 Alanine dehydrogenase/PNT, N-terminal domain; Region: AlaDh_PNT_N; cl15379 471223007337 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 471223007338 NAD(P) binding pocket [chemical binding]; other site 471223007339 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 471223007340 classical (c) SDRs; Region: SDR_c; cd05233 471223007341 NAD(P) binding site [chemical binding]; other site 471223007342 active site 471223007343 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 471223007344 Ligand Binding Site [chemical binding]; other site 471223007345 argininosuccinate lyase; Provisional; Region: PRK00855 471223007346 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 471223007347 active sites [active] 471223007348 tetramer interface [polypeptide binding]; other site 471223007349 Argininosuccinate synthase [Amino acid transport and metabolism]; Region: ArgG; COG0137 471223007350 Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate . In...; Region: Argininosuccinate_Synthase; cd01999 471223007351 ANP binding site [chemical binding]; other site 471223007352 Substrate Binding Site II [chemical binding]; other site 471223007353 Substrate Binding Site I [chemical binding]; other site 471223007354 acetyl-CoA synthetase; Provisional; Region: PRK04319 471223007355 AMP-binding enzyme; Region: AMP-binding; cl15778 471223007356 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 471223007357 DDE superfamily endonuclease; Region: DDE_5; cl02413 471223007358 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 471223007359 Archaeal putative transposase ISC1217; Region: DDE_Tnp_2; pfam04693 471223007360 Acetokinase family; Region: Acetate_kinase; cl01029 471223007361 propionate/acetate kinase; Provisional; Region: PRK12379 471223007362 Adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0827 471223007363 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 471223007364 S-adenosylmethionine binding site [chemical binding]; other site 471223007365 Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014 471223007366 dimer interface [polypeptide binding]; other site 471223007367 catalytic triad [active] 471223007368 peroxidatic and resolving cysteines [active] 471223007369 Sporulation protein YtfJ (Spore_YtfJ); Region: Spore_YtfJ; cl01596 471223007370 Protein of unknown function (DUF2953); Region: DUF2953; pfam11167 471223007371 RDD family; Region: RDD; cl00746 471223007372 signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706 471223007373 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 471223007374 tandem repeat interface [polypeptide binding]; other site 471223007375 oligomer interface [polypeptide binding]; other site 471223007376 active site residues [active] 471223007377 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; cl01255 471223007378 Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases [Lipid metabolism]; Region: Acs; COG0365 471223007379 AMP-binding enzyme; Region: AMP-binding; cl15778 471223007380 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 471223007381 Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269 471223007382 thiamine biosynthesis protein ThiI; Provisional; Region: PRK01565 471223007383 THUMP domain; Region: THUMP; cl12076 471223007384 ThiI is required for thiazole synthesis in the thiamine biosynthesis pathway. It belongs to the Adenosine Nucleotide Hydrolysis suoerfamily and predicted to bind to Adenosine nucleotide; Region: ThiI; cd01712 471223007385 Ligand Binding Site [chemical binding]; other site 471223007386 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 471223007387 cysteine desulfurase DndA; Region: DNA_S_dndA; TIGR03235 471223007388 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 471223007389 catalytic residue [active] 471223007390 septation ring formation regulator EzrA; Provisional; Region: PRK04778 471223007391 histidinol-phosphatase; Reviewed; Region: PRK08123 471223007392 GAF domain; Region: GAF; cl15785 471223007393 GAF domain; Region: GAF; cl15785 471223007394 GAF domain; Region: GAF_2; pfam13185 471223007395 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 471223007396 GAF domain; Region: GAF; cl15785 471223007397 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 471223007398 metal binding site [ion binding]; metal-binding site 471223007399 active site 471223007400 I-site; other site 471223007401 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 471223007402 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 471223007403 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 471223007404 RNA binding surface [nucleotide binding]; other site 471223007405 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 471223007406 catalytic core domain of tyrosinyl-tRNA and tryptophanyl-tRNA synthetase; Region: Tyr_Trp_RS_core; cd00395 471223007407 active site 471223007408 HIGH motif; other site 471223007409 dimer interface [polypeptide binding]; other site 471223007410 KMSKS motif; other site 471223007411 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 471223007412 RNA binding surface [nucleotide binding]; other site 471223007413 Transposase domain (DUF772); Region: DUF772; cl15789 471223007414 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 471223007415 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 471223007416 Transglycosylase; Region: Transgly; cl07896 471223007417 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 471223007418 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cl00065 471223007419 acetyl-CoA synthetase; Provisional; Region: PRK04319 471223007420 Domain of unknown function (DUF3448); Region: DUF3448; pfam11930 471223007421 AMP-binding enzyme; Region: AMP-binding; cl15778 471223007422 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 471223007423 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 471223007424 FOG: CBS domain [General function prediction only]; Region: COG0517 471223007425 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the acetoin utilization proteins in bacteria. Acetoin is a product of fermentative metabolism in many prokaryotic and eukaryotic microorganisms. They produce...; Region: CBS_pair_ACT_assoc; cd04584 471223007426 FOG: CBS domain [General function prediction only]; Region: COG0517 471223007427 C-terminal ACT domain of the Bacillus subtilis acetoin utilization protein, AcuB; Region: ACT_AcuB; cd04883 471223007428 Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123 471223007429 Histone deacetylase domain; Region: Hist_deacetyl; cl02986 471223007430 catabolite control protein A; Region: ccpA; TIGR01481 471223007431 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 471223007432 DNA binding site [nucleotide binding] 471223007433 domain linker motif; other site 471223007434 Ligand-binding domain of the catabolite control protein A (CcpA), which functions as the major transcriptional regulator of carbon catabolite repression/regulation; Region: PBP1_CcpA_like; cd06298 471223007435 dimerization interface [polypeptide binding]; other site 471223007436 effector binding site; other site 471223007437 bifunctional 3-deoxy-7-phosphoheptulonate synthase/chorismate mutase; Reviewed; Region: PRK12595 471223007438 Chorismate mutase type II; Region: CM_2; cl00693 471223007439 NeuB family; Region: NeuB; cl00496 471223007440 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 471223007441 Bacterial protein of unknown function (DUF948); Region: DUF948; cl01972 471223007442 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 471223007443 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 471223007444 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 471223007445 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 471223007446 nicotinate phosphoribosyltransferase; Provisional; Region: PRK07188 471223007447 Nicotinate phosphoribosyltransferase (NAPRTase), subgroup B. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_B; cd01571 471223007448 active site 471223007449 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 471223007450 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 471223007451 Ftsk gamma domain; Region: Ftsk_gamma; cl09645 471223007452 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 471223007453 putative tRNA-binding site [nucleotide binding]; other site 471223007454 Protein of unknown function (DUF1444); Region: DUF1444; cl02011 471223007455 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 471223007456 catalytic residues [active] 471223007457 Protein of unknown function DUF84; Region: NTPase_I-T; cl00866 471223007458 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 471223007459 M42 Peptidase, Endoglucanases; Region: M42_Frv; cd05656 471223007460 oligomer interface [polypeptide binding]; other site 471223007461 active site 471223007462 metal binding site [ion binding]; metal-binding site 471223007463 Predicted small secreted protein [Function unknown]; Region: COG5584 471223007464 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 471223007465 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 471223007466 S-adenosylmethionine binding site [chemical binding]; other site 471223007467 YtzH-like protein; Region: YtzH; pfam14165 471223007468 Phosphotransferase enzyme family; Region: APH; pfam01636 471223007469 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 471223007470 active site 471223007471 ATP binding site [chemical binding]; other site 471223007472 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: APH_ChoK_like; cd05120 471223007473 active site 471223007474 ATP binding site [chemical binding]; other site 471223007475 substrate binding site [chemical binding]; other site 471223007476 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 471223007477 Probable transposase; Region: OrfB_IS605; pfam01385 471223007478 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 471223007479 Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282 471223007480 2'-5' RNA ligase; Region: 2_5_ligase; TIGR02258 471223007481 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 471223007482 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 471223007483 sugar efflux transporter; Region: 2A0120; TIGR00899 471223007484 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 471223007485 putative substrate translocation pore; other site 471223007486 dipeptidase PepV; Reviewed; Region: PRK07318 471223007487 M20 Peptidase Xaa-His dipeptidase (PepV) degrades hydrophobic dipeptides; Region: M20_PepV; cd03888 471223007488 active site 471223007489 metal binding site [ion binding]; metal-binding site 471223007490 Helix-turn-helix domains; Region: HTH; cl00088 471223007491 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 471223007492 PseudoU_synth_RsuA: Pseudouridine synthase, Escherichia coli RsuA like. This group is comprised of eukaryotic and bacterial proteins similar to Escherichia coli RsuA. Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA...; Region: PseudoU_synth_RsuA; cd02553 471223007493 active site 471223007494 uracil binding [chemical binding]; other site 471223007495 stage V sporulation protein B; Region: spore_V_B; TIGR02900 471223007496 MatE; Region: MatE; cl10513 471223007497 MatE; Region: MatE; cl10513 471223007498 HI0933-like protein; Region: HI0933_like; pfam03486 471223007499 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 471223007500 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 471223007501 Protein of unknown function (DUF2758); Region: DUF2758; pfam10957 471223007502 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 471223007503 active site residue [active] 471223007504 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 471223007505 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 471223007506 HIGH motif; other site 471223007507 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 471223007508 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 471223007509 active site 471223007510 KMSKS motif; other site 471223007511 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 471223007512 tRNA binding surface [nucleotide binding]; other site 471223007513 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 471223007514 Major Facilitator Superfamily; Region: MFS_1; pfam07690 471223007515 putative substrate translocation pore; other site 471223007516 Protein of unknown function (DUF2524); Region: DUF2524; pfam10732 471223007517 Transposase domain (DUF772); Region: DUF772; cl15789 471223007518 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 471223007519 Predicted Fe-S oxidoreductase [General function prediction only]; Region: COG1242 471223007520 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 471223007521 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 471223007522 Protein of unknown function (DUF2600); Region: DUF2600; pfam10776 471223007523 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 471223007524 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 471223007525 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 471223007526 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 471223007527 Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645 471223007528 trimer interface [polypeptide binding]; other site 471223007529 putative metal binding site [ion binding]; other site 471223007530 Peptidase_C39 like family; Region: Peptidase_C39_2; pfam13529 471223007531 A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the 'double-glycine' leader peptides from the precursors of various bacteriocins; Region: Peptidase_C39A; cd02549 471223007532 putative active site [active] 471223007533 Asparagine synthase (glutamine-hydrolyzing) [Amino acid transport and metabolism]; Region: AsnB; COG0367 471223007534 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 471223007535 active site 471223007536 dimer interface [polypeptide binding]; other site 471223007537 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 471223007538 Ligand Binding Site [chemical binding]; other site 471223007539 Molecular Tunnel; other site 471223007540 S-adenosylmethionine synthetase; Validated; Region: PRK05250 471223007541 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 471223007542 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 471223007543 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 471223007544 DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808 471223007545 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_ATP; cd00484 471223007546 active site 471223007547 substrate-binding site [chemical binding]; other site 471223007548 metal-binding site [ion binding] 471223007549 ATP binding site [chemical binding]; other site 471223007550 Protein of unknown function (DUF2584); Region: DUF2584; pfam10763 471223007551 Dienelactone hydrolase family; Region: DLH; pfam01738 471223007552 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 471223007553 NMT1-like family; Region: NMT1_2; cl15260 471223007554 NMT1/THI5 like; Region: NMT1; pfam09084 471223007555 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 471223007556 NrtD and SsuB are the ATP-binding subunits of the bacterial ABC-type nitrate and sulfonate transport systems, respectively. ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars; Region: ABC_NrtD_SsuB_transporters; cd03293 471223007557 Walker A/P-loop; other site 471223007558 ATP binding site [chemical binding]; other site 471223007559 Q-loop/lid; other site 471223007560 ABC transporter signature motif; other site 471223007561 Walker B; other site 471223007562 D-loop; other site 471223007563 H-loop/switch region; other site 471223007564 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 471223007565 nucleoside triphosphatase YtkD; Region: nudix_YtkD; TIGR02705 471223007566 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_8; cd04665 471223007567 nudix motif; other site 471223007568 Holin family; Region: Phage_holin_4; cl01989 471223007569 Ferritin-like domain; Region: Ferritin; pfam00210 471223007570 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 471223007571 dimerization interface [polypeptide binding]; other site 471223007572 DPS ferroxidase diiron center [ion binding]; other site 471223007573 ion pore; other site 471223007574 S-Ribosylhomocysteinase (LuxS); Region: LuxS; cl00802 471223007575 Haemolytic domain; Region: Haemolytic; cl00506 471223007576 Metal binding protein AcdA. These proteins have been shown to function in the ABC uptake of Zn2+ and Mn2+ and in competence for genetic transformation and adhesion. The AcdA proteins belong to the TroA superfamily of helical backbone metal receptor...; Region: AdcA; cd01017 471223007577 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 471223007578 metal binding site [ion binding]; metal-binding site 471223007579 Uncharacterized protein conserved in bacteria (DUF2325); Region: DUF2325; cl01811 471223007580 Domain of Unknown Function (DUF1540); Region: DUF1540; pfam07561 471223007581 O-succinylbenzoic acid--CoA ligase; Provisional; Region: PRK03640 471223007582 AMP-binding enzyme; Region: AMP-binding; cl15778 471223007583 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 471223007584 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 471223007585 Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378 471223007586 substrate binding site [chemical binding]; other site 471223007587 oxyanion hole (OAH) forming residues; other site 471223007588 trimer interface [polypeptide binding]; other site 471223007589 2-succinyl-6-hydroxy-2, 4-cyclohexadiene-1-carboxylate synthase; Region: menH_SHCHC; TIGR03695 471223007590 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 471223007591 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1- carboxylate synthase; Validated; Region: PRK07449 471223007592 Pyrimidine (PYR) binding domain of 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexadiene-1- carboxylate synthase (MenD) and related proteins; Region: TPP_PYR_MenD; cd07037 471223007593 dimer interface [polypeptide binding]; other site 471223007594 tetramer interface [polypeptide binding]; other site 471223007595 PYR/PP interface [polypeptide binding]; other site 471223007596 TPP binding site [chemical binding]; other site 471223007597 Thiamine pyrophosphate (TPP) family, SHCHC synthase subfamily, TPP-binding module; composed of proteins similar to Escherichia coli 2-succinyl-6-hydroxyl-2,4-cyclohexadiene-1-carboxylic acid (SHCHC) synthase (also called MenD). SHCHC synthase plays a key...; Region: TPP_SHCHC_synthase; cd02009 471223007598 TPP-binding site; other site 471223007599 Isochorismate synthase [Coenzyme metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: MenF; COG1169 471223007600 chorismate binding enzyme; Region: Chorismate_bind; cl10555 471223007601 Transposase, Mutator family; Region: Transposase_mut; pfam00872 471223007602 MULE transposase domain; Region: MULE; pfam10551 471223007603 UbiA prenyltransferase family; Region: UbiA; cl00337 471223007604 Prokaryotic dksA/traR C4-type zinc finger; Region: zf-dskA_traR; cl00755 471223007605 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 471223007606 Probable transposase; Region: OrfB_IS605; pfam01385 471223007607 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 471223007608 Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282 471223007609 Cation efflux family; Region: Cation_efflux; cl00316 471223007610 Sortases are cysteine transpeptidases, found in gram-positive bacteria, that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. They do so by catalyzing a transpeptidation reaction in which the surface protein substrate is...; Region: Sortase; cl09098 471223007611 catalytic site [active] 471223007612 Protein of unknown function (DUF3021); Region: DUF3021; pfam11457 471223007613 LytTr DNA-binding domain; Region: LytTR; cl04498 471223007614 atypical (a) SDRs, subgroup 5; Region: SDR_a5; cd05243 471223007615 NADH(P)-binding; Region: NAD_binding_10; pfam13460 471223007616 NAD(P) binding site [chemical binding]; other site 471223007617 putative active site [active] 471223007618 luciferase-type oxidoreductase, BA3436 family; Region: lucif_BA3436; TIGR03571 471223007619 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 471223007620 tRNA methyl transferase; Region: tRNA_Me_trans; pfam03054 471223007621 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 471223007622 Helix-turn-helix domains; Region: HTH; cl00088 471223007623 Rrf2 family protein; Region: rrf2_super; TIGR00738 471223007624 Helix-turn-helix domain of transposase family ISL3; Region: HTH_Tnp_ISL3; pfam13542 471223007625 Helix-turn-helix domains; Region: HTH; cl00088 471223007626 insertion element IS2 transposase InsD; Provisional; Region: PRK14702 471223007627 Integrase core domain; Region: rve; cl01316 471223007628 Integrase core domain; Region: rve_3; cl15866 471223007629 Mu transposase, C-terminal; Region: Mu-transpos_C; pfam09299 471223007630 Type II secretory pathway, component ExeA (predicted ATPase) [Intracellular trafficking and secretion]; Region: ExeA; COG3267 471223007631 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 471223007632 Walker A motif; other site 471223007633 ATP binding site [chemical binding]; other site 471223007634 Walker B motif; other site 471223007635 arginine finger; other site 471223007636 Transposase, Mutator family; Region: Transposase_mut; pfam00872 471223007637 MULE transposase domain; Region: MULE; pfam10551 471223007638 DDE superfamily endonuclease; Region: DDE_5; cl02413 471223007639 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 471223007640 Archaeal putative transposase ISC1217; Region: DDE_Tnp_2; pfam04693 471223007641 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 471223007642 Phage portal protein, SPP1 Gp6-like; Region: Phage_prot_Gp6; pfam05133 471223007643 phage portal protein, SPP1 family; Region: portal_SPP1; TIGR01538 471223007644 large terminase protein; Provisional; Region: 17; PHA02533 471223007645 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 471223007646 MG2 domain; Region: A2M_N; pfam01835 471223007647 Protein of unknown function (DUF2762); Region: DUF2762; pfam10960 471223007648 Transposase, Mutator family; Region: Transposase_mut; pfam00872 471223007649 MULE transposase domain; Region: MULE; pfam10551 471223007650 Site-specific recombinase XerD [DNA replication, recombination, and repair]; Region: XerD; COG4974 471223007651 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 471223007652 DNA binding site [nucleotide binding] 471223007653 Int/Topo IB signature motif; other site 471223007654 active site 471223007655 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 471223007656 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 471223007657 Probable transposase; Region: OrfB_IS605; pfam01385 471223007658 Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282 471223007659 Transposase IS200 like; Region: Y1_Tnp; cl00848 471223007660 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 471223007661 EamA-like transporter family; Region: EamA; cl01037 471223007662 Uncharacterized membrane protein [Function unknown]; Region: SapB; COG1285 471223007663 MgtC family; Region: MgtC; pfam02308 471223007664 Staphylococcal nuclease homologues; Region: SNc; smart00318 471223007665 Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cl00140 471223007666 Catalytic site; other site 471223007667 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 471223007668 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 471223007669 Coenzyme A binding pocket [chemical binding]; other site 471223007670 Small acid-soluble spore protein H family; Region: SspH; cl06949 471223007671 Ion channel; Region: Ion_trans_2; cl11596 471223007672 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 471223007673 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 471223007674 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl15357 471223007675 YugN-like family; Region: YugN; pfam08868 471223007676 glucose-6-phosphate isomerase; Provisional; Region: pgi; PRK14097 471223007677 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 471223007678 active site 471223007679 dimer interface [polypeptide binding]; other site 471223007680 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 471223007681 dimer interface [polypeptide binding]; other site 471223007682 active site 471223007683 Uncharacterized oxidoreductases, Fe-dependent alcohol dehydrogenase family [Energy production and conversion]; Region: COG1979 471223007684 Butanol dehydrogenase catalyzes the conversion of butyraldehyde to butanol with the cofactor NAD(P)H being oxidized in the process; Region: BDH; cd08187 471223007685 dimer interface [polypeptide binding]; other site 471223007686 active site 471223007687 metal binding site [ion binding]; metal-binding site 471223007688 Domain of unknown function (DUF378); Region: DUF378; cl00943 471223007689 general stress protein 13; Validated; Region: PRK08059 471223007690 S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists of...; Region: S1_RPS1_repeat_hs4; cd05692 471223007691 RNA binding site [nucleotide binding]; other site 471223007692 hypothetical protein; Validated; Region: PRK07682 471223007693 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 471223007694 pyridoxal 5'-phosphate binding site [chemical binding]; other site 471223007695 homodimer interface [polypeptide binding]; other site 471223007696 catalytic residue [active] 471223007697 Helix-turn-helix domains; Region: HTH; cl00088 471223007698 Helix-turn-helix domains; Region: HTH; cl00088 471223007699 Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities [Amino acid transport and metabolism]; Region: MalY; COG1168 471223007700 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 471223007701 pyridoxal 5'-phosphate binding site [chemical binding]; other site 471223007702 homodimer interface [polypeptide binding]; other site 471223007703 catalytic residue [active] 471223007704 Copper/zinc superoxide dismutase (SOD). superoxide dismutases catalyse the conversion of superoxide radicals to molecular oxygen. Three evolutionarily distinct families of SODs are known, of which the copper/zinc-binding family is one. Defects in the...; Region: Cu-Zn_Superoxide_Dismutase; cd00305 471223007705 E-class dimer interface [polypeptide binding]; other site 471223007706 P-class dimer interface [polypeptide binding]; other site 471223007707 active site 471223007708 Cu2+ binding site [ion binding]; other site 471223007709 Zn2+ binding site [ion binding]; other site 471223007710 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 471223007711 transposase, putative, N-terminal domain; Region: tspaseT_teng_N; TIGR01765 471223007712 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 471223007713 Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282 471223007714 Na+/H+ antiporter subunit; Region: PhaG_MnhG_YufB; cl00583 471223007715 Multiple resistance and pH regulation protein F (MrpF / PhaF); Region: MrpF_PhaF; cl09154 471223007716 Na+/H+ ion antiporter subunit; Region: MNHE; cl00807 471223007717 putative monovalent cation/H+ antiporter subunit D; Reviewed; Region: PRK07691 471223007718 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; cl14187 471223007719 NADH-ubiquinone/plastoquinone oxidoreductase chain 4L; Region: Oxidored_q2; cl00492 471223007720 Domain of unknown function (DUF4040); Region: DUF4040; cl00676 471223007721 monovalent cation/H+ antiporter subunit A; Reviewed; Region: PRK12645 471223007722 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; cl14187 471223007723 Domain of unknown function (DUF4040); Region: DUF4040; cl00676 471223007724 ECF-type riboflavin transporter, S component; Region: ECF-ribofla_trS; cl01942 471223007725 Phosphate transporter family; Region: PHO4; cl00396 471223007726 Phosphate transport regulator (distant homolog of PhoU) [Inorganic ion transport and metabolism]; Region: COG1392 471223007727 multifunctional aminopeptidase A; Provisional; Region: PRK00913 471223007728 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 471223007729 interface (dimer of trimers) [polypeptide binding]; other site 471223007730 Substrate-binding/catalytic site; other site 471223007731 Zn-binding sites [ion binding]; other site 471223007732 Cobalamin binding protein BtuF. These proteins have been shown to function as initial receptors in ABC transport of vitamin B12 (cobalamin) in eubacterial and some archaeal species. They belong to the TroA superfamily of helical backbone metal receptor...; Region: BtuF; cd01144 471223007733 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 471223007734 cobalamin binding residues [chemical binding]; other site 471223007735 putative BtuC binding residues; other site 471223007736 dimer interface [polypeptide binding]; other site 471223007737 3D domain; Region: 3D; cl01439 471223007738 Putative membrane protein; Region: YuiB; pfam14068 471223007739 chaperone protein DnaJ; Provisional; Region: PRK14295 471223007740 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 471223007741 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 471223007742 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 471223007743 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 471223007744 Transposase, Mutator family; Region: Transposase_mut; pfam00872 471223007745 MULE transposase domain; Region: MULE; pfam10551 471223007746 Iron-sulphur cluster biosynthesis; Region: Fe-S_biosyn; cl00400 471223007747 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 471223007748 Diaminopimelate epimerase; Region: DAP_epimerase; cl14668 471223007749 Diaminopimelate epimerase; Region: DAP_epimerase; cl14668 471223007750 Protein of unknown function (DUF1450); Region: DUF1450; cl11488 471223007751 DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808 471223007752 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 471223007753 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 471223007754 Protein of unknown function (DUF1462); Region: DUF1462; cl11552 471223007755 NifU-like domain; Region: NifU; cl00484 471223007756 homoserine kinase; Provisional; Region: PRK01212 471223007757 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 471223007758 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 471223007759 threonine synthase; Reviewed; Region: PRK06721 471223007760 Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants; Region: Thr-synth_1; cd01563 471223007761 homodimer interface [polypeptide binding]; other site 471223007762 pyridoxal 5'-phosphate binding site [chemical binding]; other site 471223007763 catalytic residue [active] 471223007764 homoserine dehydrogenase; Provisional; Region: PRK06349 471223007765 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 471223007766 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 471223007767 ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881 471223007768 glyoxylate reductase; Reviewed; Region: PRK13243 471223007769 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 471223007770 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 471223007771 Phosphatidylglycerophosphatase A; a bacterial membrane-associated enzyme involved in lipid metabolism; Region: PgpA; cd06971 471223007772 tetramer interfaces [polypeptide binding]; other site 471223007773 binuclear metal-binding site [ion binding]; other site 471223007774 HAD-superfamily subfamily IIA hydrolase, TIGR01457; Region: HAD-SF-IIA-hyp2 471223007775 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 471223007776 active site 471223007777 motif I; other site 471223007778 motif II; other site 471223007779 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 471223007780 Protein of unknown function DUF86; Region: DUF86; cl01031 471223007781 Protein of unknown function (DUF3055); Region: DUF3055; pfam11256 471223007782 Protein of unknown function (DUF1027); Region: DUF1027; cl09961 471223007783 Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ); Region: Spore_YhcN_YlaJ; pfam09580 471223007784 lipoyl synthase; Provisional; Region: PRK05481 471223007785 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 471223007786 FeS/SAM binding site; other site 471223007787 Peptidase family M23; Region: Peptidase_M23; pfam01551 471223007788 Sodium:neurotransmitter symporter family; Region: SNF; cl11976 471223007789 Sporulation protein YunB (Spo_YunB); Region: Spore_YunB; cl09783 471223007790 Domain of unknown function (DUF1805); Region: DUF1805; cl01339 471223007791 Escherichia coli UshA-like family, N-terminal metallophosphatase domain; Region: MPP_UshA_N_like; cd00845 471223007792 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 471223007793 active site 471223007794 metal binding site [ion binding]; metal-binding site 471223007795 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 471223007796 Predicted permeases [General function prediction only]; Region: COG0730; cl00498 471223007797 Protein of unknown function DUF72; Region: DUF72; cl00777 471223007798 Domain of unknown function (DUF771); Region: DUF771; cl09962 471223007799 Transposase, Mutator family; Region: Transposase_mut; pfam00872 471223007800 MULE transposase domain; Region: MULE; pfam10551 471223007801 Uncharacterized protein family (UPF0051); Region: UPF0051; cl03223 471223007802 FeS assembly protein SufB; Region: sufB; TIGR01980 471223007803 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 471223007804 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 471223007805 trimerization site [polypeptide binding]; other site 471223007806 active site 471223007807 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 471223007808 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 471223007809 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 471223007810 catalytic residue [active] 471223007811 Cysteine desulfurase activator SufB [Posttranslational modification, protein turnover, chaperones]; Region: SufB; COG0719 471223007812 Uncharacterized protein family (UPF0051); Region: UPF0051; cl03223 471223007813 FeS assembly ATPase SufC; Region: sufC; TIGR01978 471223007814 ABC-type transport system involved in Fe-S cluster assembly, ATPase component. Biosynthesis of iron-sulfur clusters (Fe-S) depends on multiprotein systems. The SUF system of E. coli and Erwinia chrysanthemi is important for Fe-S biogenesis under...; Region: ABC_FeS_Assembly; cd03217 471223007815 Walker A/P-loop; other site 471223007816 ATP binding site [chemical binding]; other site 471223007817 Q-loop/lid; other site 471223007818 ABC transporter signature motif; other site 471223007819 Walker B; other site 471223007820 D-loop; other site 471223007821 H-loop/switch region; other site 471223007822 NMT1-like family; Region: NMT1_2; cl15260 471223007823 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 471223007824 DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153 471223007825 MetN (also known as YusC) is an ABC-type transporter encoded by metN of the metNPQ operon in Bacillus subtilis that is involved in methionine transport. Other members of this system include the MetP permease and the MetQ substrate binding protein. ABC...; Region: ABC_MetN_methionine_transporter; cd03258 471223007826 Walker A/P-loop; other site 471223007827 ATP binding site [chemical binding]; other site 471223007828 Q-loop/lid; other site 471223007829 ABC transporter signature motif; other site 471223007830 Walker B; other site 471223007831 D-loop; other site 471223007832 H-loop/switch region; other site 471223007833 NIL domain; Region: NIL; cl09633 471223007834 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 471223007835 Probable transposase; Region: OrfB_IS605; pfam01385 471223007836 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 471223007837 Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282 471223007838 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 471223007839 catalytic residues [active] 471223007840 Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718 471223007841 active site 471223007842 metal binding site [ion binding]; metal-binding site 471223007843 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 471223007844 lipoyl attachment site [posttranslational modification]; other site 471223007845 Arsenate Reductase (ArsC) family, unknown subfamily; uncharacterized proteins containing a CXXC motif with similarity to thioredoxin (TRX)-fold arsenic reductases, ArsC. Proteins containing a redox active CXXC motif like TRX and glutaredoxin (GRX)...; Region: ArsC_like; cd03036 471223007846 ArsC family; Region: ArsC; pfam03960 471223007847 putative ArsC-like catalytic residues; other site 471223007848 putative TRX-like catalytic residues [active] 471223007849 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 471223007850 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 471223007851 active site 471223007852 acetyl-CoA acetyltransferase; Provisional; Region: PRK07661 471223007853 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 471223007854 dimer interface [polypeptide binding]; other site 471223007855 active site 471223007856 3-hydroxyacyl-CoA dehydrogenase [Lipid metabolism]; Region: FadB; COG1250 471223007857 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 471223007858 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 471223007859 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 471223007860 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 471223007861 substrate binding site [chemical binding]; other site 471223007862 oxyanion hole (OAH) forming residues; other site 471223007863 YuzL-like protein; Region: YuzL; pfam14115 471223007864 Proline dehydrogenase; Region: Pro_dh; cl03282 471223007865 Coat F domain; Region: Coat_F; cl15836 471223007866 adenosylmethionine--8-amino-7-oxononanoate transaminase; Provisional; Region: PRK06916 471223007867 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 471223007868 inhibitor-cofactor binding pocket; inhibition site 471223007869 pyridoxal 5'-phosphate binding site [chemical binding]; other site 471223007870 catalytic residue [active] 471223007871 AAA domain; Region: AAA_26; pfam13500 471223007872 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 471223007873 Dethiobiotin synthetase (DTBS) is the penultimate enzyme in the biotin biosynthesis pathway in Escherichia coli and other microorganisms. The enzyme catalyzes formation of the ureido ring of dethiobiotin from (7R,8S)-7,8-diaminononanoic acid (DAPA) and...; Region: DTBS; cd03109 471223007874 ECF-type riboflavin transporter, S component; Region: ECF-ribofla_trS; cl01942 471223007875 Transposase domain (DUF772); Region: DUF772; cl15789 471223007876 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 471223007877 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; cl14891 471223007878 Integrase core domain; Region: rve; cl01316 471223007879 Domain of unknown function (DUF4277); Region: DUF4277; pfam14104 471223007880 Transposase [DNA replication, recombination, and repair]; Region: COG5421 471223007881 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 471223007882 SmpB-tmRNA interface; other site 471223007883 ribonuclease R; Region: RNase_R; TIGR02063 471223007884 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 471223007885 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 471223007886 RNB domain; Region: RNB; pfam00773 471223007887 S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase play an important...; Region: S1_RNase_R; cd04471 471223007888 RNA binding site [nucleotide binding]; other site 471223007889 Esterase/lipase [General function prediction only]; Region: COG1647 471223007890 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 471223007891 Preprotein translocase SecG subunit; Region: SecG; cl09123 471223007892 enolase; Provisional; Region: eno; PRK00077 471223007893 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 471223007894 dimer interface [polypeptide binding]; other site 471223007895 metal binding site [ion binding]; metal-binding site 471223007896 substrate binding pocket [chemical binding]; other site 471223007897 Phosphoglyceromutase [Carbohydrate transport and metabolism]; Region: GpmI; COG0696 471223007898 Sulfatase; Region: Sulfatase; cl10460 471223007899 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 471223007900 substrate binding site [chemical binding]; other site 471223007901 dimer interface [polypeptide binding]; other site 471223007902 catalytic triad [active] 471223007903 Phosphoglycerate kinase; Region: PGK; pfam00162 471223007904 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 471223007905 substrate binding site [chemical binding]; other site 471223007906 hinge regions; other site 471223007907 ADP binding site [chemical binding]; other site 471223007908 catalytic site [active] 471223007909 glyceraldehyde-3-phosphate dehydrogenase; Validated; Region: PRK07729 471223007910 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 471223007911 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; cl15856 471223007912 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 471223007913 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 471223007914 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 471223007915 RNA polymerase factor sigma-54; Reviewed; Region: PRK05932 471223007916 Sigma-54 factor, Activator interacting domain (AID); Region: Sigma54_AID; pfam00309 471223007917 Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963 471223007918 Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552 471223007919 Clp protease; Region: CLP_protease; pfam00574 471223007920 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 471223007921 oligomer interface [polypeptide binding]; other site 471223007922 active site residues [active] 471223007923 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 471223007924 dimerization domain swap beta strand [polypeptide binding]; other site 471223007925 regulatory protein interface [polypeptide binding]; other site 471223007926 active site 471223007927 regulatory phosphorylation site [posttranslational modification]; other site 471223007928 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1481 471223007929 Sporulation Regulator WhiA N terminal; Region: WhiA_N; pfam10298 471223007930 family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187 471223007931 Uncharacterized protein family UPF0052; Region: UPF0052; pfam01933 471223007932 phosphate binding site [ion binding]; other site 471223007933 putative substrate binding pocket [chemical binding]; other site 471223007934 dimer interface [polypeptide binding]; other site 471223007935 P-loop ATPase protein family; Region: ATP_bind_2; cl15794 471223007936 Predicted P-loop-containing kinase [General function prediction only]; Region: COG1660 471223007937 MutT homolog-1 (MTH1) is a member of the Nudix hydrolase superfamily. MTH1, the mammalian counterpart of MutT, hydrolyzes oxidized purine nucleoside triphosphates, such as 8-oxo-dGTP and 2-hydroxy-ATP, to monophosphates, thereby preventing the...; Region: MTH1; cd03427 471223007938 putative active site [active] 471223007939 nucleotide binding site [chemical binding]; other site 471223007940 nudix motif; other site 471223007941 putative metal binding site [ion binding]; other site 471223007942 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 471223007943 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 471223007944 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 471223007945 TPR repeat; Region: TPR_11; pfam13414 471223007946 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 471223007947 binding surface 471223007948 TPR motif; other site 471223007949 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 471223007950 binding surface 471223007951 Tetratricopeptide repeat; Region: TPR_16; pfam13432 471223007952 TPR motif; other site 471223007953 bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase protein; Reviewed; Region: PRK02759 471223007954 Phosphoribosyl-AMP cyclohydrolase; Region: PRA-CH; cl00344 471223007955 MazG nucleotide pyrophosphohydrolase domain; Region: MazG; cl00345 471223007956 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 471223007957 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 471223007958 substrate binding site [chemical binding]; other site 471223007959 glutamase interaction surface [polypeptide binding]; other site 471223007960 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 471223007961 phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Region: TIGR00007 471223007962 catalytic residues [active] 471223007963 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13141 471223007964 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 471223007965 putative active site [active] 471223007966 oxyanion strand; other site 471223007967 catalytic triad [active] 471223007968 imidazoleglycerol-phosphate dehydratase; Validated; Region: hisB; PRK00951 471223007969 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 471223007970 putative active site pocket [active] 471223007971 4-fold oligomerization interface [polypeptide binding]; other site 471223007972 metal binding residues [ion binding]; metal-binding site 471223007973 3-fold/trimer interface [polypeptide binding]; other site 471223007974 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 471223007975 histidinol dehydrogenase; Region: hisD; TIGR00069 471223007976 NAD binding site [chemical binding]; other site 471223007977 dimerization interface [polypeptide binding]; other site 471223007978 product binding site; other site 471223007979 substrate binding site [chemical binding]; other site 471223007980 zinc binding site [ion binding]; other site 471223007981 catalytic residues [active] 471223007982 ATP phosphoribosyltransferase; Region: HisG; cl15266 471223007983 ATP phosphoribosyltransferase regulatory subunit; Provisional; Region: hisZ; PRK12292 471223007984 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: HisRS-like_core; cd00773 471223007985 dimer interface [polypeptide binding]; other site 471223007986 motif 1; other site 471223007987 active site 471223007988 motif 2; other site 471223007989 motif 3; other site 471223007990 Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647 471223007991 trimer interface [polypeptide binding]; other site 471223007992 active site 471223007993 substrate binding site [chemical binding]; other site 471223007994 CoA binding site [chemical binding]; other site 471223007995 pyrophosphatase PpaX; Provisional; Region: PRK13288 471223007996 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 471223007997 active site 471223007998 motif I; other site 471223007999 motif II; other site 471223008000 Nucleoside recognition; Region: Gate; cl00486 471223008001 Nucleoside recognition; Region: Gate; cl00486 471223008002 Prolipoprotein diacylglyceryl transferase; Region: LGT; cl00478 471223008003 HPr kinase/phosphorylase; Provisional; Region: PRK05428 471223008004 DRTGG domain; Region: DRTGG; cl12147 471223008005 HprK/P, the bifunctional histidine-containing protein kinase/phosphatase, controls the phosphorylation state of the phosphocarrier protein HPr and regulates the utilization of carbon sources by gram-positive bacteria. It catalyzes both the ATP-dependent...; Region: HprK_C; cd01918 471223008006 Hpr binding site; other site 471223008007 active site 471223008008 homohexamer subunit interaction site [polypeptide binding]; other site 471223008009 Membrane protein of unknown function; Region: DUF360; cl00850 471223008010 Uncharacterized conserved protein [Function unknown]; Region: COG3595 471223008011 Domain of unknown function (DUF4098); Region: DUF4098; pfam13345 471223008012 Tic20-like protein; Region: Tic20; pfam09685 471223008013 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 471223008014 The excision repair protein UvrA domain I; Nucleotide excision repair in eubacteria is a process that repairs DNA damage by the removal of a 12-13-mer oligonucleotide containing the lesion. Recognition and cleavage of the damaged DNA is a multistep...; Region: ABC_UvrA_I; cd03270 471223008015 The excision repair protein UvrA domain I; Nucleotide excision repair in eubacteria is a process that repairs DNA damage by the removal of a 12-13-mer oligonucleotide containing the lesion. Recognition and cleavage of the damaged DNA is a multistep...; Region: ABC_UvrA_I; cd03270 471223008016 The excision repair protein UvrA domain II; Nucleotide excision repair in eubacteria is a process that repairs DNA damage by the removal of a 12-13-mer oligonucleotide containing the lesion. Recognition and cleavage of the damaged DNA is a multistep...; Region: ABC_UvrA_II; cd03271 471223008017 excinuclease ABC subunit B; Provisional; Region: PRK05298 471223008018 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 471223008019 ATP binding site [chemical binding]; other site 471223008020 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 471223008021 nucleotide binding region [chemical binding]; other site 471223008022 ATP-binding site [chemical binding]; other site 471223008023 Ultra-violet resistance protein B; Region: UvrB; pfam12344 471223008024 UvrB/uvrC motif; Region: UVR; pfam02151 471223008025 Uncharacterized protein conserved in bacteria (DUF2198); Region: DUF2198; cl11559 471223008026 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 471223008027 polar chromosome segregation protein; Reviewed; Region: racA; PRK13182 471223008028 Helix-Turn-Helix DNA binding domain of truncated MerR-like proteins; Region: HTH_MerR-trunc; cd04762 471223008029 DNA binding residues [nucleotide binding] 471223008030 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 471223008031 C-terminal peptidase (prc); Region: prc; TIGR00225 471223008032 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 471223008033 protein binding site [polypeptide binding]; other site 471223008034 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 471223008035 Catalytic dyad [active] 471223008036 Putative peptidoglycan binding domain; Region: PG_binding_1; cl15437 471223008037 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 471223008038 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 471223008039 Probable transposase; Region: OrfB_IS605; pfam01385 471223008040 Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282 471223008041 Transposase IS200 like; Region: Y1_Tnp; cl00848 471223008042 TATA element modulatory factor 1 DNA binding; Region: TMF_DNA_bd; pfam12329 471223008043 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3883 471223008044 Peptidase family M23; Region: Peptidase_M23; pfam01551 471223008045 Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177 471223008046 FtsX-like permease family; Region: FtsX; cl15850 471223008047 Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884 471223008048 FtsE is a hydrophilic nucleotide-binding protein that binds FtsX to form a heterodimeric ATP-binding cassette (ABC)-type transporter that associates with the bacterial inner membrane. The FtsE/X transporter is thought to be involved in cell division and...; Region: ABC_FtsE_transporter; cd03292 471223008049 Walker A/P-loop; other site 471223008050 ATP binding site [chemical binding]; other site 471223008051 Q-loop/lid; other site 471223008052 ABC transporter signature motif; other site 471223008053 Walker B; other site 471223008054 D-loop; other site 471223008055 H-loop/switch region; other site 471223008056 Cytochrome c; Region: Cytochrom_C; cl11414 471223008057 Uncharacterized conserved protein [Function unknown]; Region: COG1284 471223008058 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 471223008059 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 471223008060 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; cl10498 471223008061 peptide chain release factor 2; Validated; Region: prfB; PRK00578 471223008062 CemA family; Region: CemA; cl03855 471223008063 RF-1 domain; Region: RF-1; cl02875 471223008064 RF-1 domain; Region: RF-1; cl02875 471223008065 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 471223008066 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 471223008067 SecA preprotein cross-linking domain; Region: SecA_PP_bind; cl03078 471223008068 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 471223008069 nucleotide binding region [chemical binding]; other site 471223008070 ATP-binding site [chemical binding]; other site 471223008071 SEC-C motif; Region: SEC-C; pfam02810 471223008072 RaiA ('ribosome-associated inhibitor A', also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal A site; Region: RaiA; cd00552 471223008073 30S subunit binding site; other site 471223008074 Flagellar protein FliT; Region: FliT; cl05125 471223008075 Flagellar protein FliS; Region: FliS; cl00654 471223008076 flagellar capping protein; Validated; Region: fliD; PRK07737 471223008077 Flagellar hook-associated protein 2 C-terminus; Region: FliD_N; pfam02465 471223008078 Flagellar hook-associated protein 2 C-terminus; Region: FliD_C; pfam07195 471223008079 FlaG protein; Region: FlaG; cl00591 471223008080 Protein of unknown function (DUF4046); Region: DUF4046; pfam13255 471223008081 Flagellin and related hook-associated proteins [Cell motility and secretion]; Region: FlgL; COG1344 471223008082 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 471223008083 Herpesvirus latent membrane protein 1 (LMP1); Region: Herpes_LMP1; pfam05297 471223008084 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 471223008085 Global regulator protein family; Region: CsrA; cl00670 471223008086 FliW protein; Region: FliW; cl00740 471223008087 CoA enzyme activase uncharacterized domain (DUF2229); Region: DUF2229; pfam09989 471223008088 flagellar hook-associated protein FlgL; Validated; Region: flgL; PRK07701 471223008089 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 471223008090 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 471223008091 flagellar hook-associated protein FlgK; Validated; Region: flgK; PRK07739 471223008092 Flagella basal body rod protein; Region: Flg_bb_rod; cl15793 471223008093 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; cl15855 471223008094 FlgN protein; Region: FlgN; cl09176 471223008095 Anti-sigma-28 factor, FlgM; Region: FlgM; cl01052 471223008096 flagellar operon protein TIGR03826; Region: YvyF 471223008097 Protein of unknown function (DUF327); Region: DUF327; cl00753 471223008098 flagellar hook-associated protein FlgL; Provisional; Region: flgL; PRK12718 471223008099 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 471223008100 flagellin; Provisional; Region: PRK12804 471223008101 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 471223008102 Flagellar protein FliS; Region: FliS; cl00654 471223008103 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257; cl15822 471223008104 MAEBL; Provisional; Region: PTZ00121 471223008105 Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040 471223008106 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 471223008107 active site 471223008108 Superfamily II DNA/RNA helicase required for DNA uptake (late competence protein) [DNA replication, recombination, and repair]; Region: comFA; COG4098 471223008109 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 471223008110 ATP binding site [chemical binding]; other site 471223008111 putative Mg++ binding site [ion binding]; other site 471223008112 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 471223008113 nucleotide binding region [chemical binding]; other site 471223008114 ATP-binding site [chemical binding]; other site 471223008115 Uncharacterized protein, DegV family COG1307; Region: DegV; cl00577 471223008116 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 471223008117 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 471223008118 active site 471223008119 phosphorylation site [posttranslational modification] 471223008120 intermolecular recognition site; other site 471223008121 dimerization interface [polypeptide binding]; other site 471223008122 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 471223008123 DNA binding residues [nucleotide binding] 471223008124 dimerization interface [polypeptide binding]; other site 471223008125 Sensor protein DegS; Region: DegS; pfam05384 471223008126 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 471223008127 Histidine kinase; Region: HisKA_3; pfam07730 471223008128 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 471223008129 ATP binding site [chemical binding]; other site 471223008130 Mg2+ binding site [ion binding]; other site 471223008131 G-X-G motif; other site 471223008132 uncharacterized protein, YigZ family; Region: IMPACT_YIGZ; TIGR00257 471223008133 Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205 471223008134 Domain of unknown function (DUF1949); Region: DUF1949; pfam09186 471223008135 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581 471223008136 UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472 471223008137 This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853 471223008138 Mg++ binding site [ion binding]; other site 471223008139 putative catalytic motif [active] 471223008140 substrate binding site [chemical binding]; other site 471223008141 preprotein translocase subunit SecA; Reviewed; Region: PRK09200 471223008142 SecA preprotein cross-linking domain; Region: SecA_PP_bind; cl03078 471223008143 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 471223008144 nucleotide binding region [chemical binding]; other site 471223008145 ATP-binding site [chemical binding]; other site 471223008146 dolichyl-phosphate beta-D-mannosyltransferase; Region: PLN02726 471223008147 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 471223008148 Ligand binding site; other site 471223008149 Putative Catalytic site; other site 471223008150 DXD motif; other site 471223008151 Uncharacterized conserved protein (DUF2304); Region: DUF2304; cl01034 471223008152 Small Multidrug Resistance protein; Region: Multi_Drug_Res; cl00910 471223008153 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl15769 471223008154 Domain of unknown function (DUF4277); Region: DUF4277; pfam14104 471223008155 Transposase [DNA replication, recombination, and repair]; Region: COG5421 471223008156 Putative catalytic polysaccharide deacetylase domain of uncharacterized protein yadE and similar proteins; Region: CE4_yadE_5s; cd10966 471223008157 putative active site [active] 471223008158 putative metal binding site [ion binding]; other site 471223008159 Membrane-fusion protein [Cell envelope biogenesis, outer membrane]; Region: AcrA; COG0845 471223008160 Protein of unknown function (DUF3221); Region: DUF3221; pfam11518 471223008161 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 471223008162 Probable transposase; Region: OrfB_IS605; pfam01385 471223008163 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 471223008164 Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282 471223008165 PemK-like protein; Region: PemK; cl00995 471223008166 Antidote-toxin recognition MazE; Region: Antitoxin-MazE; cl00877 471223008167 Domain of unknown function (DUF955); Region: DUF955; cl01076 471223008168 Transposase DDE domain group 1; Region: DDE_Tnp_1_4; pfam13701 471223008169 Integral membrane protein DUF95; Region: DUF95; cl00572 471223008170 BlaR1 peptidase M56; Region: Peptidase_M56; cl15829 471223008171 Peptidase family M48; Region: Peptidase_M48; cl12018 471223008172 Transposase IS200 like; Region: Y1_Tnp; cl00848 471223008173 Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606 471223008174 Subunit ChlI of Mg-chelatase; Region: ChlI; cl12214 471223008175 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 471223008176 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335 471223008177 DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808 471223008178 Bacterial pre-peptidase C-terminal domain; Region: PPC; pfam04151 471223008179 Bacterial pre-peptidase C-terminal domain; Region: PPC; pfam04151 471223008180 Restriction endonuclease; Region: Mrr_cat; cl00516 471223008181 Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277 471223008182 Domain of unknown function (DUF1508); Region: DUF1508; cl01356 471223008183 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 471223008184 Transposase; Region: DDE_Tnp_ISL3; pfam01610 471223008185 Helix-turn-helix domains; Region: HTH; cl00088 471223008186 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 471223008187 non-specific DNA binding site [nucleotide binding]; other site 471223008188 salt bridge; other site 471223008189 sequence-specific DNA binding site [nucleotide binding]; other site 471223008190 Site-specific recombinase XerD [DNA replication, recombination, and repair]; Region: XerD; COG4974 471223008191 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 471223008192 DNA binding site [nucleotide binding] 471223008193 Int/Topo IB signature motif; other site 471223008194 active site 471223008195 Domain of unknown function (DUF4277); Region: DUF4277; pfam14104 471223008196 Transposase [DNA replication, recombination, and repair]; Region: COG5421 471223008197 Transposase IS200 like; Region: Y1_Tnp; cl00848 471223008198 Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606 471223008199 Subunit ChlI of Mg-chelatase; Region: ChlI; cl12214 471223008200 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 471223008201 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335 471223008202 Site-specific recombinase XerD [DNA replication, recombination, and repair]; Region: XerD; COG4974 471223008203 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 471223008204 DNA binding site [nucleotide binding] 471223008205 Int/Topo IB signature motif; other site 471223008206 active site 471223008207 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 471223008208 MPN+ (JAMM) motif; other site 471223008209 Zinc-binding site [ion binding]; other site 471223008210 S-layer homology domain; Region: SLH; pfam00395 471223008211 S-layer homology domain; Region: SLH; pfam00395 471223008212 S-layer homology domain; Region: SLH; pfam00395 471223008213 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383 471223008214 Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307 471223008215 O-Antigen ligase; Region: Wzy_C; cl04850 471223008216 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 471223008217 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 471223008218 The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533 471223008219 UDP-N-acetyl-D-mannosaminuronate dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: WecC; COG0677 471223008220 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 471223008221 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 471223008222 Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; cl09156 471223008223 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 471223008224 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 471223008225 Uncharacterized membrane protein, putative virulence factor [General function prediction only]; Region: MviN; COG0728 471223008226 S-layer homology domain; Region: SLH; pfam00395 471223008227 S-layer homology domain; Region: SLH; pfam00395 471223008228 lysozyme_like domain. This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222 471223008229 NlpC/P60 family; Region: NLPC_P60; cl11438 471223008230 S-layer homology domain; Region: SLH; pfam00395 471223008231 S-layer homology domain; Region: SLH; pfam00395 471223008232 Peptidase S8 family domain in Subtilisin proteins; Region: Peptidases_S8_Subtilisin_subset; cd07477 471223008233 active site 471223008234 catalytic residues [active] 471223008235 Peptidase S8 family domain in Subtilisin proteins; Region: Peptidases_S8_Subtilisin_subset; cd07477 471223008236 active site 471223008237 catalytic residues [active] 471223008238 S-layer homology domain; Region: SLH; pfam00395 471223008239 S-layer homology domain; Region: SLH; pfam00395 471223008240 S-layer homology domain; Region: SLH; pfam00395 471223008241 S-layer homology domain; Region: SLH; pfam00395 471223008242 S-layer homology domain; Region: SLH; pfam00395 471223008243 Bacterial SH3 domain; Region: SH3_3; cl02551 471223008244 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 471223008245 active site 471223008246 metal binding site [ion binding]; metal-binding site 471223008247 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 471223008248 Transposase; Region: DDE_Tnp_ISL3; pfam01610 471223008249 Protein of unknown function (DUF3888); Region: DUF3888; pfam13027 471223008250 Transposase; Region: DEDD_Tnp_IS110; pfam01548 471223008251 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 471223008252 Integrase core domain; Region: rve; cl01316 471223008253 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3415 471223008254 Helix-turn-helix domains; Region: HTH; cl00088 471223008255 Winged helix-turn helix; Region: HTH_33; pfam13592 471223008256 Transposase; Region: DEDD_Tnp_IS110; pfam01548 471223008257 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 471223008258 UDP-N-acetylglucosamine 2-epimerase; Region: wecB; TIGR00236 471223008259 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 471223008260 active site 471223008261 homodimer interface [polypeptide binding]; other site 471223008262 Putative peptidoglycan binding domain; Region: PG_binding_1; cl15437 471223008263 Putative peptidoglycan binding domain; Region: PG_binding_1; cl15437 471223008264 Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409 471223008265 Putative peptidoglycan binding domain; Region: PG_binding_1; cl15437 471223008266 Putative peptidoglycan binding domain; Region: PG_binding_1; cl15437 471223008267 molybdopterin biosynthesis-like protein MoeZ; Validated; Region: PRK07878 471223008268 NlpC/P60 family; Region: NLPC_P60; cl11438 471223008269 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 471223008270 non-specific DNA binding site [nucleotide binding]; other site 471223008271 salt bridge; other site 471223008272 sequence-specific DNA binding site [nucleotide binding]; other site 471223008273 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 471223008274 transposase, putative, N-terminal domain; Region: tspaseT_teng_N; TIGR01765 471223008275 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 471223008276 Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282 471223008277 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 471223008278 dimer interface [polypeptide binding]; other site 471223008279 ssDNA binding site [nucleotide binding]; other site 471223008280 tetramer (dimer of dimers) interface [polypeptide binding]; other site 471223008281 YwpF-like protein; Region: YwpF; pfam14183 471223008282 Sortase D (SrtD) is a membrane transpeptidase found in gram-positive bacteria that anchors surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the surface protein substrate is cleaved...; Region: Sortase_D_4; cd05828 471223008283 active site 471223008284 catalytic site [active] 471223008285 aspartate kinase; Reviewed; Region: PRK09034 471223008286 AAK_AKiii-YclM-BS: Amino Acid Kinase Superfamily (AAK), AKiii-YclM-BS; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine plus threonine-sensitive aspartokinase isoenzyme AKIII, a monofunctional class enzyme found in...; Region: AAK_AKiii-YclM-BS; cd04245 471223008287 putative catalytic residues [active] 471223008288 putative nucleotide binding site [chemical binding]; other site 471223008289 putative aspartate binding site [chemical binding]; other site 471223008290 ACT domains located C-terminal to the catalytic domain of the lysine plus threonine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-YclM-BS_1; cd04911 471223008291 allosteric regulatory residue; other site 471223008292 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 471223008293 Protein of unknown function (DUF1284); Region: DUF1284; cl01419 471223008294 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 471223008295 Probable transposase; Region: OrfB_IS605; pfam01385 471223008296 Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282 471223008297 Ralstonia eutrophus NAD+-dependent acetaldehyde dehydrogenase II-like; Region: ALDH_ACDHII-AcoD; cd07116 471223008298 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 471223008299 NAD(P) binding site [chemical binding]; other site 471223008300 catalytic residues [active] 471223008301 Protein of unknown function (DUF779); Region: DUF779; cl01432 471223008302 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 471223008303 Major Facilitator Superfamily; Region: MFS_1; pfam07690 471223008304 putative substrate translocation pore; other site 471223008305 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 471223008306 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 471223008307 Helix-turn-helix domains; Region: HTH; cl00088 471223008308 Protein of unknown function (DUF3990); Region: DUF3990; pfam13151 471223008309 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 471223008310 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 471223008311 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 471223008312 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 471223008313 dimer interface [polypeptide binding]; other site 471223008314 conserved gate region; other site 471223008315 putative PBP binding loops; other site 471223008316 ABC-ATPase subunit interface; other site 471223008317 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 471223008318 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 471223008319 dimer interface [polypeptide binding]; other site 471223008320 conserved gate region; other site 471223008321 putative PBP binding loops; other site 471223008322 ABC-ATPase subunit interface; other site 471223008323 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 471223008324 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 471223008325 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 471223008326 Response regulator containing CheY-like receiver domain and AraC-type DNA-binding domain [Signal transduction mechanisms]; Region: COG4753 471223008327 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 471223008328 active site 471223008329 phosphorylation site [posttranslational modification] 471223008330 intermolecular recognition site; other site 471223008331 dimerization interface [polypeptide binding]; other site 471223008332 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 471223008333 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 471223008334 Periplasmic sugar-binding domain of active transport systems that are members of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_sugar_binding_like; cd01536 471223008335 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 471223008336 ligand binding site [chemical binding]; other site 471223008337 D-lactate dehydrogenase [cytochrome]; Region: PLN02805 471223008338 FAD binding domain; Region: FAD_binding_4; pfam01565 471223008339 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 471223008340 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 471223008341 alpha subunit interface [polypeptide binding]; other site 471223008342 TPP binding site [chemical binding]; other site 471223008343 heterodimer interface [polypeptide binding]; other site 471223008344 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 471223008345 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_x; TIGR03181 471223008346 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 471223008347 TPP-binding site [chemical binding]; other site 471223008348 tetramer interface [polypeptide binding]; other site 471223008349 heterodimer interface [polypeptide binding]; other site 471223008350 phosphorylation loop region [posttranslational modification] 471223008351 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 471223008352 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 471223008353 E3 interaction surface; other site 471223008354 lipoyl attachment site [posttranslational modification]; other site 471223008355 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; cl02008 471223008356 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_1; cd08352 471223008357 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 471223008358 putative metal binding site [ion binding]; other site 471223008359 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 471223008360 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 471223008361 VanZ like family; Region: VanZ; cl01971 471223008362 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 471223008363 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 471223008364 substrate binding site [chemical binding]; other site 471223008365 dimer interface [polypeptide binding]; other site 471223008366 ATP binding site [chemical binding]; other site 471223008367 DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808 471223008368 Domain of unknown function (DUF3870); Region: DUF3870; pfam12986 471223008369 Protein of unknown function (DUF819); Region: DUF819; cl02317 471223008370 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 471223008371 L-Ala-D/L-Glu epimerase catalyzes the epimerization of L-Ala-D/L-Glu and other dipeptides. The genomic context and the substrate specificity of characterized members of this family from E.coli and B.subtilis indicates a possible role in the metabolism of...; Region: L-Ala-DL-Glu_epimerase; cd03319 471223008372 active site 471223008373 Orthopoxvirus protein of unknown function (DUF830); Region: DUF830; cl13998 471223008374 NlpC/P60 family; Region: NLPC_P60; cl11438 471223008375 Sodium:solute symporter family; Region: SSF; cl00456 471223008376 Protein of unknown function (DUF3311); Region: DUF3311; pfam11755 471223008377 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 471223008378 M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886 471223008379 metal binding site [ion binding]; metal-binding site 471223008380 dimer interface [polypeptide binding]; other site 471223008381 allantoate amidohydrolase; Reviewed; Region: PRK09290 471223008382 M20 Peptidase beta-alanine synthase, an amidohydrolase; Region: M20_bAS; cd03884 471223008383 active site 471223008384 metal binding site [ion binding]; metal-binding site 471223008385 dimer interface [polypeptide binding]; other site 471223008386 Protein of unknown function (DUF1861); Region: DUF1861; pfam08950 471223008387 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 471223008388 Protein export membrane protein; Region: SecD_SecF; cl14618 471223008389 Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004 471223008390 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 471223008391 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 471223008392 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 471223008393 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 471223008394 DNA binding residues [nucleotide binding] 471223008395 PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812 471223008396 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_9; cd07245 471223008397 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 471223008398 dimer interface [polypeptide binding]; other site 471223008399 putative metal binding site [ion binding]; other site 471223008400 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; cl14891 471223008401 Integrase core domain; Region: rve; cl01316 471223008402 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3807 471223008403 Bacterial SH3 domain; Region: SH3_3; cl02551 471223008404 Bacterial SH3 domain; Region: SH3_3; cl02551 471223008405 Bacterial SH3 domain; Region: SH3_3; cl02551 471223008406 Bacterial SH3 domain; Region: SH3_3; cl02551 471223008407 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 471223008408 active site 471223008409 metal binding site [ion binding]; metal-binding site 471223008410 Branched-chain amino acid transport protein; Region: Branch_AA_trans; cl00547 471223008411 Transposase domain (DUF772); Region: DUF772; cl15789 471223008412 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 471223008413 Helix-turn-helix domain of transposase family ISL3; Region: HTH_Tnp_ISL3; pfam13542 471223008414 Helix-turn-helix domains; Region: HTH; cl00088 471223008415 insertion element IS2 transposase InsD; Provisional; Region: PRK14702 471223008416 Integrase core domain; Region: rve; cl01316 471223008417 Integrase core domain; Region: rve_3; cl15866 471223008418 Mu transposase, C-terminal; Region: Mu-transpos_C; pfam09299 471223008419 Type II secretory pathway, component ExeA (predicted ATPase) [Intracellular trafficking and secretion]; Region: ExeA; COG3267 471223008420 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 471223008421 Walker A motif; other site 471223008422 ATP binding site [chemical binding]; other site 471223008423 Walker B motif; other site 471223008424 arginine finger; other site 471223008425 DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808 471223008426 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 471223008427 dimerization interface [polypeptide binding]; other site 471223008428 putative DNA binding site [nucleotide binding]; other site 471223008429 putative Zn2+ binding site [ion binding]; other site 471223008430 Macro domain, a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ADP-ribose polymerases). Some macro domains recognize poly...; Region: Macro; cl00019 471223008431 ADP-ribose binding site [chemical binding]; other site 471223008432 GAF domain; Region: GAF_2; pfam13185 471223008433 GAF domain; Region: GAF; cl15785 471223008434 Permeases of the major facilitator superfamily [General function prediction only]; Region: COG2270 471223008435 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 471223008436 putative substrate translocation pore; other site 471223008437 Osmosensitive K+ channel histidine kinase [Signal transduction mechanisms]; Region: KdpD; COG2205 471223008438 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 471223008439 PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812 471223008440 EamA-like transporter family; Region: EamA; cl01037 471223008441 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 471223008442 EamA-like transporter family; Region: EamA; cl01037 471223008443 Putative transposase, YhgA-like; Region: Transposase_31; pfam04754 471223008444 conserved hypothetical protein (putative transposase or invertase); Region: T_den_put_tspse; TIGR01784 471223008445 SEC-C motif; Region: SEC-C; pfam02810 471223008446 Plasmid pRiA4b ORF-3-like protein; Region: PRiA4_ORF3; pfam07929 471223008447 SEC-C motif; Region: SEC-C; pfam02810 471223008448 SEC-C motif; Region: SEC-C; pfam02810 471223008449 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 471223008450 Probable transposase; Region: OrfB_IS605; pfam01385 471223008451 Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282 471223008452 SEC-C motif; Region: SEC-C; pfam02810 471223008453 SWIM zinc finger; Region: SWIM; cl15408 471223008454 Uncharacterized conserved protein [Function unknown]; Region: COG4715 471223008455 SNF2 Helicase protein; Region: DUF3670; pfam12419 471223008456 SNF2 family N-terminal domain; Region: SNF2_N; pfam00176 471223008457 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 471223008458 ATP binding site [chemical binding]; other site 471223008459 putative Mg++ binding site [ion binding]; other site 471223008460 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 471223008461 nucleotide binding region [chemical binding]; other site 471223008462 ATP-binding site [chemical binding]; other site 471223008463 Protein of unknown function (DUF1861); Region: DUF1861; pfam08950 471223008464 Macro domain, a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ADP-ribose polymerases). Some macro domains recognize poly...; Region: Macro; cl00019 471223008465 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118 471223008466 putative peptidoglycan binding site; other site 471223008467 L,D-transpeptidase catalytic domain; Region: YkuD; cl15405 471223008468 conserved hypothetical protein (putative transposase or invertase); Region: T_den_put_tspse; TIGR01784 471223008469 Protein of unknown function DUF262; Region: DUF262; cl14890 471223008470 Protein of unknown function DUF262; Region: DUF262; cl14890 471223008471 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 471223008472 Probable transposase; Region: OrfB_IS605; pfam01385 471223008473 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 471223008474 Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282 471223008475 AAA domain; Region: AAA_21; pfam13304 471223008476 ABC (ATP-binding cassette) transporter nucleotide-binding domain; ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars, ions, peptides, and more complex organic molecules. The...; Region: ABC_ATPase; cd00267 471223008477 Q-loop/lid; other site 471223008478 ABC transporter signature motif; other site 471223008479 Walker B; other site 471223008480 D-loop; other site 471223008481 H-loop/switch region; other site 471223008482 PIN domain of ribonucleases (toxins), VapC, FitB, and PAE0151 of bacterial and archaeal toxin/antitoxin-like operons, and other similar homologs; Region: PIN_VapC-like; cd09861 471223008483 putative active site [active] 471223008484 Regulators of stationary/sporulation gene expression [Transcription]; Region: AbrB; COG2002 471223008485 Antidote-toxin recognition MazE; Region: Antitoxin-MazE; cl00877 471223008486 Preprotein translocase subunit SecB. SecB is a cytoplasmic component of the multisubunit membrane-bound enzyme termed Sec protein translocase, which is the main constituent of the General Secretory (type II) Pathway involved in translocation of nascent...; Region: Translocase_SecB; cl00251 471223008487 Preprotein binding site; other site 471223008488 SecA binding site; other site 471223008489 Protein of unknown function (DUF2283); Region: DUF2283; cl02251 471223008490 Protein of unknown function (DUF3467); Region: DUF3467; pfam11950 471223008491 Transposase IS200 like; Region: Y1_Tnp; cl00848 471223008492 Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606 471223008493 Subunit ChlI of Mg-chelatase; Region: ChlI; cl12214 471223008494 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 471223008495 Walker A motif; other site 471223008496 ATP binding site [chemical binding]; other site 471223008497 Walker B motif; other site 471223008498 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335 471223008499 Protein of unknown function DUF262; Region: DUF262; cl14890 471223008500 Protein of unknown function DUF262; Region: DUF262; cl14890 471223008501 Protein of unknown function DUF262; Region: DUF262; cl14890 471223008502 aminotransferase, LLPSF_NHT_00031 family; Region: NHT_00031; TIGR04181 471223008503 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 471223008504 inhibitor-cofactor binding pocket; inhibition site 471223008505 pyridoxal 5'-phosphate binding site [chemical binding]; other site 471223008506 catalytic residue [active] 471223008507 HAD superfamily (subfamily IA) hydrolase, TIGR02253; Region: CTE7 471223008508 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 471223008509 carbamoyl phosphate synthase-like protein; Provisional; Region: PRK12767 471223008510 ATP-grasp domain; Region: ATP-grasp_4; cl03087 471223008511 Bacterial sugar transferase; Region: Bac_transf; cl00939 471223008512 This family is most closely related to the GT1 family of glycosyltransferases. cap1E in Streptococcus pneumoniae is required for the synthesis of type 1 capsular polysaccharides; Region: GT1_cap1E_like; cd03808 471223008513 sugar transferase, PEP-CTERM/EpsH1 system associated; Region: stp2; TIGR03088 471223008514 putative ADP-binding pocket [chemical binding]; other site 471223008515 Vi polysaccharide biosynthesis protein TviB; Provisional; Region: PRK15182 471223008516 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 471223008517 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 471223008518 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 471223008519 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 471223008520 UDP glucuronic acid epimerase, extended (e) SDRs; Region: UDP_GE_SDE_e; cd05253 471223008521 putative NAD(P) binding site [chemical binding]; other site 471223008522 active site 471223008523 putative substrate binding site [chemical binding]; other site 471223008524 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 471223008525 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 471223008526 O-antigen polysaccharide polymerase Wzy; Region: O-ag_pol_Wzy; pfam14296 471223008527 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 471223008528 This family is most closely related to the GT1 family of glycosyltransferases. capH in Staphylococcus aureus has been shown to be required for the biosynthesis of the type 1 capsular polysaccharide (CP1); Region: GT1_CapH_like; cd03812 471223008529 putative ADP-binding pocket [chemical binding]; other site 471223008530 MatE; Region: MatE; cl10513 471223008531 Transposase domain (DUF772); Region: DUF772; cl15789 471223008532 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 471223008533 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 471223008534 active site 471223008535 tetramer interface; other site 471223008536 chromosome segregation protein SMC, primarily archaeal type; Region: SMC_prok_A; TIGR02169 471223008537 DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808 471223008538 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581 471223008539 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229 471223008540 active site 471223008541 catalytic triad [active] 471223008542 capsular exopolysaccharide family; Region: eps_fam; TIGR01007 471223008543 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 471223008544 Capsular polysaccharide biosynthesis protein [Cell envelope biogenesis, outer membrane]; Region: COG3944 471223008545 Chain length determinant protein; Region: Wzz; cl15801 471223008546 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 471223008547 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 471223008548 DNA-directed RNA polymerase subunit beta; Region: EpuA; pfam11772 471223008549 Flagellar basal body rod protein [Cell motility and secretion]; Region: FlgG; COG4786 471223008550 Flagella basal body rod protein; Region: Flg_bb_rod; cl15793 471223008551 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; cl15855 471223008552 Flagellar basal body rod protein [Cell motility and secretion]; Region: FlgG; COG4786 471223008553 Flagella basal body rod protein; Region: Flg_bb_rod; cl15793 471223008554 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; cl15855 471223008555 rod shape-determining protein Mbl; Provisional; Region: PRK13928 471223008556 Actin; An ubiquitous protein involved in the formation of filaments that are a major component of the cytoskeleton. Interaction with myosin provides the basis of muscular contraction and many aspects of cell motility. Each actin protomer binds one...; Region: ACTIN; cl11528 471223008557 ATP binding site [chemical binding]; other site 471223008558 profilin binding site; other site 471223008559 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 471223008560 Intracellular proteinase inhibitor; Region: BsuPI; pfam12690 471223008561 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; cl08040 471223008562 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019 471223008563 Peptidase family M23; Region: Peptidase_M23; pfam01551 471223008564 Apocytochrome F, C-terminal; Region: Apocytochr_F_C; cl03168 471223008565 stage II sporulation protein D; Region: spore_II_D; TIGR02870 471223008566 Stage II sporulation protein; Region: SpoIID; pfam08486 471223008567 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 471223008568 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 471223008569 hinge; other site 471223008570 active site 471223008571 Protein of unknown function (DUF1779); Region: DUF1779; pfam08680 471223008572 Protein of unknown function (DUF1146); Region: DUF1146; cl11486 471223008573 NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777 471223008574 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; cl14187 471223008575 NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846 471223008576 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; cl14187 471223008577 NADH:ubiquinone oxidoreductase subunit L; Reviewed; Region: PRK06590 471223008578 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; cl14187 471223008579 NADH-Ubiquinone oxidoreductase (complex I) subunit C-terminus; Region: Oxidored_q1_C; pfam01010 471223008580 NADH-ubiquinone/plastoquinone oxidoreductase chain 4L; Region: Oxidored_q2; cl00492 471223008581 NADH dehydrogenase subunit J; Provisional; Region: PRK06433; cl14634 471223008582 NADH:ubiquinone oxidoreductase subunit 6 (chain J) [Energy production and conversion]; Region: NuoJ; COG0839 471223008583 NADH dehydrogenase subunit I; Provisional; Region: PRK05888 471223008584 4Fe-4S binding domain; Region: Fer4; cl02805 471223008585 4Fe-4S binding domain; Region: Fer4; cl02805 471223008586 NADH dehydrogenase; Region: NADHdh; cl00469 471223008587 Nickel-dependent hydrogenase; Region: NiFeSe_Hases; cl00417 471223008588 Respiratory-chain NADH dehydrogenase, 49 Kd subunit; Region: Complex1_49kDa; pfam00346 471223008589 Respiratory-chain NADH dehydrogenase, 30 Kd subunit; Region: Complex1_30kDa; cl15771 471223008590 NADH dehydrogenase subunit B; Validated; Region: PRK06411 471223008591 NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; cl15792 471223008592 NADH-ubiquinone/plastoquinone oxidoreductase, chain 3; Region: Oxidored_q4; cl00535 471223008593 F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571 471223008594 ATP synthase, Delta/Epsilon chain, beta-sandwich domain; Region: ATP-synt_DE_N; cl10033 471223008595 ATP synthase, Delta/Epsilon chain, long alpha-helix domain; Region: ATP-synt_DE; pfam00401 471223008596 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 471223008597 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; cl15275 471223008598 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 471223008599 alpha subunit interaction interface [polypeptide binding]; other site 471223008600 Walker A motif; other site 471223008601 ATP binding site [chemical binding]; other site 471223008602 Walker B motif; other site 471223008603 inhibitor binding site; inhibition site 471223008604 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 471223008605 ATP synthase; Region: ATP-synt; cl00365 471223008606 F0F1 ATP synthase subunit gamma; Provisional; Region: PRK13422 471223008607 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 471223008608 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; cl15275 471223008609 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 471223008610 beta subunit interaction interface [polypeptide binding]; other site 471223008611 Walker A motif; other site 471223008612 ATP binding site [chemical binding]; other site 471223008613 Walker B motif; other site 471223008614 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 471223008615 Plant ATP synthase F0; Region: YMF19; cl07975 471223008616 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 471223008617 Plant ATP synthase F0; Region: YMF19; cl07975 471223008618 ATP synthase subunit C; Region: ATP-synt_C; cl00466 471223008619 ATP synthase A chain; Region: ATP-synt_A; cl00413 471223008620 ATP synthase I chain; Region: ATP_synt_I; cl09170 471223008621 Putative F0F1-ATPase subunit (ATPase_gene1); Region: ATPase_gene1; cl09754 471223008622 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 471223008623 active site 471223008624 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 471223008625 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 471223008626 dimer interface [polypeptide binding]; other site 471223008627 glycine-pyridoxal phosphate binding site [chemical binding]; other site 471223008628 active site 471223008629 folate binding site [chemical binding]; other site 471223008630 Protein of unknown function (DUF436); Region: DUF436; cl01860 471223008631 Ribose/Galactose Isomerase; Region: LacAB_rpiB; cl00485 471223008632 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 471223008633 dimerization interface [polypeptide binding]; other site 471223008634 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 471223008635 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 471223008636 dimer interface [polypeptide binding]; other site 471223008637 putative CheW interface [polypeptide binding]; other site 471223008638 Low molecular weight phosphatase family; Region: LMWPc; cd00115 471223008639 Low molecular weight phosphotyrosine protein phosphatase; Region: LMWPc; pfam01451 471223008640 active site 471223008641 Predicted membrane protein [Function unknown]; Region: COG1971 471223008642 Domain of unknown function DUF; Region: DUF204; pfam02659 471223008643 Domain of unknown function DUF; Region: DUF204; pfam02659 471223008644 Telomere recombination; Region: Sua5_yciO_yrdC; cl00305 471223008645 Putative GTP-binding controlling metal-binding; Region: SUA5; pfam03481 471223008646 Stage II sporulation protein R (spore_II_R); Region: Spore_II_R; cl09775 471223008647 protein-(glutamine-N5) methyltransferase, release factor-specific; Region: RF_mod_PrmC; TIGR03534 471223008648 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 471223008649 S-adenosylmethionine binding site [chemical binding]; other site 471223008650 peptide chain release factor 1; Validated; Region: prfA; PRK00591 471223008651 RF-1 domain; Region: RF-1; cl02875 471223008652 RF-1 domain; Region: RF-1; cl02875 471223008653 DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808 471223008654 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 471223008655 (2R,3R)-2,3-butanediol dehydrogenase; Region: butanediol_DH_like; cd08233 471223008656 putative NAD(P) binding site [chemical binding]; other site 471223008657 catalytic Zn binding site [ion binding]; other site 471223008658 Transposase domain (DUF772); Region: DUF772; cl15789 471223008659 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 471223008660 thymidine kinase; Provisional; Region: PRK04296 471223008661 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 471223008662 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 471223008663 Probable transposase; Region: OrfB_IS605; pfam01385 471223008664 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 471223008665 Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282 471223008666 Ribosomal protein L31; Region: Ribosomal_L31; cl00377 471223008667 transcription termination factor Rho; Provisional; Region: rho; PRK09376 471223008668 Rho termination factor, N-terminal domain; Region: Rho_N; cl06505 471223008669 Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459 471223008670 RNA binding site [nucleotide binding]; other site 471223008671 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128 471223008672 multimer interface [polypeptide binding]; other site 471223008673 Walker A motif; other site 471223008674 ATP binding site [chemical binding]; other site 471223008675 Walker B motif; other site 471223008676 Bacterial fructose-1,6-bisphosphatase, glpX-encoded. A dimeric enzyme dependent on Mg(2+). glpX-encoded FPBase (FBPase class II) differs from other members of the inositol-phosphatase superfamily by permutation of secondary structure elements. The core...; Region: FBPase_glpX; cd01516 471223008677 putative active site [active] 471223008678 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 471223008679 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 471223008680 hinge; other site 471223008681 active site 471223008682 Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956 471223008683 active site 471223008684 intersubunit interactions; other site 471223008685 catalytic residue [active] 471223008686 hypothetical protein; Provisional; Region: PRK08185 471223008687 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 471223008688 intersubunit interface [polypeptide binding]; other site 471223008689 active site 471223008690 zinc binding site [ion binding]; other site 471223008691 Na+ binding site [ion binding]; other site 471223008692 Response regulator receiver domain; Region: Response_reg; pfam00072 471223008693 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 471223008694 active site 471223008695 phosphorylation site [posttranslational modification] 471223008696 intermolecular recognition site; other site 471223008697 dimerization interface [polypeptide binding]; other site 471223008698 Transposase domain (DUF772); Region: DUF772; cl15789 471223008699 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 471223008700 Protein of unknown function (DUF2529); Region: DUF2529; pfam10740 471223008701 CTP synthetase; Validated; Region: pyrG; PRK05380 471223008702 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 471223008703 Catalytic site [active] 471223008704 active site 471223008705 UTP binding site [chemical binding]; other site 471223008706 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 471223008707 active site 471223008708 putative oxyanion hole; other site 471223008709 catalytic triad [active] 471223008710 DNA-directed RNA polymerase delta subunit; Region: RNA_pol_delta; cl01319 471223008711 methylmalonyl CoA mutase B12 binding domain. This domain binds to B12 (adenosylcobamide), which initiates the conversion of succinyl CoA and methylmalonyl CoA by forming an adenosyl radical, which then undergoes a rearrangement exchanging a hydrogen atom...; Region: MM_CoA_mut_B12_BD; cd02071 471223008712 B12 binding site [chemical binding]; other site 471223008713 cobalt ligand [ion binding]; other site 471223008714 Putative periplasmic protein kinase ArgK and related GTPases of G3E family [Amino acid transport and metabolism]; Region: ArgK; COG1703 471223008715 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 471223008716 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM)-like family; contains proteins similar to MCM, and the large subunit of Streptomyces coenzyme B12-dependent isobutyryl-CoA mutase (ICM). MCM catalyzes the isomerization of...; Region: MM_CoA_mutase; cl00817 471223008717 Methylmalonyl-CoA mutase, N-terminal domain/subunit [Lipid metabolism]; Region: Sbm; COG1884 471223008718 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 471223008719 Helix-turn-helix domains; Region: HTH; cl00088 471223008720 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 471223008721 Short chain acyl-CoA dehydrogenases and eukaryotic short/branched chain acyl-CoA dehydrogenases; Region: SCAD_SBCAD; cd01158 471223008722 FAD binding site [chemical binding]; other site 471223008723 homotetramer interface [polypeptide binding]; other site 471223008724 substrate binding pocket [chemical binding]; other site 471223008725 catalytic base [active] 471223008726 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 471223008727 Short chain acyl-CoA dehydrogenases and eukaryotic short/branched chain acyl-CoA dehydrogenases; Region: SCAD_SBCAD; cd01158 471223008728 FAD binding site [chemical binding]; other site 471223008729 homotetramer interface [polypeptide binding]; other site 471223008730 substrate binding pocket [chemical binding]; other site 471223008731 catalytic base [active] 471223008732 3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK05808 471223008733 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 471223008734 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 471223008735 acetyl-CoA acetyltransferase; Provisional; Region: PRK08235 471223008736 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 471223008737 dimer interface [polypeptide binding]; other site 471223008738 active site 471223008739 Nitrate reductase gamma subunit; Region: Nitrate_red_gam; cl00959 471223008740 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 471223008741 Cysteine-rich domain; Region: CCG; pfam02754 471223008742 Cysteine-rich domain; Region: CCG; pfam02754 471223008743 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 471223008744 putative active site [active] 471223008745 catalytic site [active] 471223008746 catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112 471223008747 PLD-like domain; Region: PLDc_2; pfam13091 471223008748 putative active site [active] 471223008749 catalytic site [active] 471223008750 Protein of unknown function (DUF1427); Region: DUF1427; cl01771 471223008751 arginyl-tRNA synthetase; Reviewed; Region: argS; PRK01611 471223008752 Arginyl tRNA synthetase N terminal domain; Region: Arg_tRNA_synt_N; cl04104 471223008753 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 471223008754 active site 471223008755 HIGH motif; other site 471223008756 KMSK motif region; other site 471223008757 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 471223008758 tRNA binding surface [nucleotide binding]; other site 471223008759 anticodon binding site; other site 471223008760 Domain of unknown function (DUF1934); Region: DUF1934; cl01870 471223008761 Arginase family; Region: Arginase; cl00306 471223008762 spermidine synthase; Provisional; Region: PRK00811 471223008763 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl15754 471223008764 Transglycosylase; Region: Transgly; cl07896 471223008765 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 471223008766 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 471223008767 YwhD family; Region: YwhD; pfam08741 471223008768 Uncharacterized homologs of Site-2 protease (S2P), zinc metalloproteases (MEROPS family M50) which cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of the...; Region: S2P-M50_like_1; cd06158 471223008769 active site 471223008770 putative substrate binding region [chemical binding]; other site 471223008771 4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cd00491 471223008772 active site 1 [active] 471223008773 dimer interface [polypeptide binding]; other site 471223008774 hexamer interface [polypeptide binding]; other site 471223008775 active site 2 [active] 471223008776 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 471223008777 Uncharacterized conserved protein [Function unknown]; Region: COG3465 471223008778 HD superfamily phosphohydrolases [General function prediction only]; Region: COG1078 471223008779 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 471223008780 Protein of unknown function (DUF1450); Region: DUF1450; cl11488 471223008781 Uncharacterized protein family (UPF0236); Region: UPF0236; pfam06782 471223008782 Transposase DDE domain group 1; Region: DDE_Tnp_1_4; pfam13701 471223008783 putative spore coat protein regulator protein YlbO; Provisional; Region: PRK13923 471223008784 transcription factor, RsfA family; Region: DNA_bind_RsfA; TIGR02894 471223008785 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 471223008786 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 471223008787 Phosphate acetyl/butaryl transferase; Region: PTA_PTB; cl00390 471223008788 Phosphotransacetylase [Energy production and conversion]; Region: Pta; COG0280 471223008789 Chlorite dismutase; Region: Chlor_dismutase; cl01280 471223008790 Cell Wall Hydrolase; Region: Hydrolase_2; pfam07486 471223008791 Spore coat protein (Spore_GerQ); Region: Spore_GerQ; cl09881 471223008792 Protein of unknown function (DUF423); Region: DUF423; cl01008 471223008793 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 471223008794 ligand binding site [chemical binding]; other site 471223008795 active site 471223008796 UGI interface [polypeptide binding]; other site 471223008797 catalytic site [active] 471223008798 glycyl-tRNA synthetase; Provisional; Region: PRK04173 471223008799 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it attaches...; Region: class_II_aaRS-like_core; cl00268 471223008800 motif 1; other site 471223008801 Glycyl-tRNA synthetase (GlyRS)-like class II core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes. It is responsible for the attachment of glycine to the 3'...; Region: GlyRS-like_core; cd00774 471223008802 active site 471223008803 motif 2; other site 471223008804 motif 3; other site 471223008805 GlyRS Glycyl-anticodon binding domain. GlyRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: GlyRS_anticodon; cd00858 471223008806 anticodon binding site; other site 471223008807 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 471223008808 active site 471223008809 benzoate transport; Region: 2A0115; TIGR00895 471223008810 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 471223008811 putative substrate translocation pore; other site 471223008812 hypothetical protein; Provisional; Region: PRK09272 471223008813 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 471223008814 Helix-turn-helix domains; Region: HTH; cl00088 471223008815 M20 Peptidase Arginine utilization protein, RocB; Region: M20_ArgE_RocB; cd05654 471223008816 Arginine degradation protein (predicted deacylase) [Amino acid transport and metabolism]; Region: RocB; COG4187 471223008817 putative metal binding site [ion binding]; other site 471223008818 putative dimer interface [polypeptide binding]; other site 471223008819 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210 471223008820 HPr interaction site; other site 471223008821 glycerol kinase (GK) interaction site [polypeptide binding]; other site 471223008822 active site 471223008823 phosphorylation site [posttranslational modification] 471223008824 Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508 471223008825 Helix-turn-helix domains; Region: HTH; cl00088 471223008826 Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686 471223008827 Alanine dehydrogenase/PNT, N-terminal domain; Region: AlaDh_PNT_N; cl15379 471223008828 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 471223008829 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 471223008830 dimer interface [polypeptide binding]; other site 471223008831 substrate binding site [chemical binding]; other site 471223008832 ATP binding site [chemical binding]; other site 471223008833 Transposase domain (DUF772); Region: DUF772; cl15789 471223008834 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 471223008835 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 471223008836 Probable transposase; Region: OrfB_IS605; pfam01385 471223008837 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 471223008838 Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282 471223008839 Sodium:solute symporter family; Region: SSF; cl00456 471223008840 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 471223008841 substrate binding pocket [chemical binding]; other site 471223008842 membrane-bound complex binding site; other site 471223008843 hinge residues; other site 471223008844 SpoU rRNA Methylase family; Region: SpoU_methylase; cl00362 471223008845 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 471223008846 Spore germination protein; Region: Spore_permease; cl15802 471223008847 Pyruvate formate lyase 1; Region: PFL1; cd01678 471223008848 formate acetyltransferase 1; Region: pyr_form_ly_1; TIGR01255 471223008849 coenzyme A binding site [chemical binding]; other site 471223008850 active site 471223008851 catalytic residues [active] 471223008852 glycine loop; other site 471223008853 pyruvate formate-lyase 1-activating enzyme; Region: PFLA; TIGR02493 471223008854 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 471223008855 FeS/SAM binding site; other site 471223008856 Predicted transcriptional regulator containing an HTH domain and an uncharacterized domain shared with the mammalian protein Schlafen [Transcription]; Region: COG2865 471223008857 ATP-dependent DNA helicase recG C-terminal; Region: HATPase_c_4; pfam13749 471223008858 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 471223008859 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 471223008860 YhfW family, C-terminal Rieske domain; YhfW is a protein of unknown function with an N-terminal DadA-like (glycine/D-amino acid dehydrogenase) domain and a C-terminal Rieske domain. The Rieske domain is a [2Fe-2S] cluster binding domain involved in...; Region: Rieske_YhfW_C; cd03477 471223008861 [2Fe-2S] cluster binding site [ion binding]; other site 471223008862 putative PTS system transporter subunits IIBC; Provisional; Region: PRK11404 471223008863 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 471223008864 P-loop; other site 471223008865 active site 471223008866 phosphorylation site [posttranslational modification] 471223008867 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; cl00557 471223008868 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 471223008869 Helix-turn-helix domains; Region: HTH; cl00088 471223008870 Helix-turn-helix domains; Region: HTH; cl00088 471223008871 PRD domain; Region: PRD; cl15445 471223008872 PRD domain; Region: PRD; cl15445 471223008873 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 471223008874 P-loop; other site 471223008875 active site 471223008876 phosphorylation site [posttranslational modification] 471223008877 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 471223008878 active site 471223008879 phosphorylation site [posttranslational modification] 471223008880 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 471223008881 active site 471223008882 phosphorylation site [posttranslational modification] 471223008883 Phosphomannose isomerase [Carbohydrate transport and metabolism]; Region: ManA; COG1482 471223008884 Phosphomannose isomerase type I; Region: PMI_typeI; cl15429 471223008885 Glycerate kinase family; Region: Gly_kinase; cl00841 471223008886 Na+-H+ antiporter family; Region: Na_H_antiport_2; cl15264 471223008887 Na+-H+ antiporter family; Region: Na_H_antiport_2; cl15264 471223008888 Fatty acid desaturase; Region: FA_desaturase; pfam00487 471223008889 The Delta6 Fatty Acid Desaturase (Delta6-FADS)-like CD includes the integral-membrane enzymes: delta-4, delta-5, delta-6, delta-8, delta-8-sphingolipid, and delta-11 desaturases found in vertebrates, higher plants, fungi, and bacteria. These desaturases...; Region: Delta6-FADS-like; cd03506 471223008890 putative di-iron ligands [ion binding]; other site 471223008891 Uncharacterized conserved protein [Function unknown]; Region: COG1576; cl00679 471223008892 Predicted SPOUT methyltransferase; Region: SPOUT_MTase; pfam02590 471223008893 YyzF-like protein; Region: YyzF; cl15733 471223008894 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149 471223008895 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 471223008896 protein binding site [polypeptide binding]; other site 471223008897 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 471223008898 YycH protein; Region: YycI; cl02015 471223008899 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4863 471223008900 YycH protein; Region: YycH; pfam07435 471223008901 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: VicK; COG5002 471223008902 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 471223008903 dimerization interface [polypeptide binding]; other site 471223008904 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 471223008905 dimer interface [polypeptide binding]; other site 471223008906 phosphorylation site [posttranslational modification] 471223008907 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 471223008908 ATP binding site [chemical binding]; other site 471223008909 Mg2+ binding site [ion binding]; other site 471223008910 G-X-G motif; other site 471223008911 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 471223008912 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 471223008913 active site 471223008914 phosphorylation site [posttranslational modification] 471223008915 intermolecular recognition site; other site 471223008916 dimerization interface [polypeptide binding]; other site 471223008917 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 471223008918 DNA binding site [nucleotide binding] 471223008919 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 471223008920 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 471223008921 GDP-binding site [chemical binding]; other site 471223008922 ACT binding site; other site 471223008923 IMP binding site; other site 471223008924 replicative DNA helicase; Provisional; Region: PRK05748 471223008925 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 471223008926 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 471223008927 Walker A motif; other site 471223008928 ATP binding site [chemical binding]; other site 471223008929 Walker B motif; other site 471223008930 DNA binding loops [nucleotide binding] 471223008931 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 471223008932 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 471223008933 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 471223008934 Predicted signaling protein consisting of a modified GGDEF domain and a DHH domain [Signal transduction mechanisms]; Region: COG3887 471223008935 Phosphatidylserine decarboxylase; Region: PS_Dcarbxylase; cl03656 471223008936 Class III nucleotidyl cyclases; Region: Nucleotidyl_cyc_III; cl11967 471223008937 DHH family; Region: DHH; pfam01368 471223008938 DHHA1 domain; Region: DHHA1; pfam02272 471223008939 Predicted membrane protein (DUF2232); Region: DUF2232; cl01728 471223008940 Ribosomal protein S18; Region: Ribosomal_S18; cl00373 471223008941 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 471223008942 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 471223008943 dimer interface [polypeptide binding]; other site 471223008944 ssDNA binding site [nucleotide binding]; other site 471223008945 tetramer (dimer of dimers) interface [polypeptide binding]; other site 471223008946 Ribosomal protein S6; Region: Ribosomal_S6; cl00414 471223008947 GTP-binding protein YchF; Reviewed; Region: PRK09601 471223008948 YchF GTPase; Region: YchF; cd01900 471223008949 G1 box; other site 471223008950 GTP/Mg2+ binding site [chemical binding]; other site 471223008951 Switch I region; other site 471223008952 G2 box; other site 471223008953 Switch II region; other site 471223008954 G3 box; other site 471223008955 G4 box; other site 471223008956 G5 box; other site 471223008957 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 471223008958 Bacterial protein of unknown function (DUF951); Region: DUF951; cl01864 471223008959 mechanosensitive channel MscS; Provisional; Region: PRK10334 471223008960 Mechanosensitive ion channel; Region: MS_channel; pfam00924 471223008961 Protein of unknown function (DUF1256); Region: DUF1256; cl06087 471223008962 Protein of unknown function (DUF554); Region: DUF554; cl00784 471223008963 ParB-like partition proteins; Region: parB_part; TIGR00180 471223008964 ParB-like nuclease domain; Region: ParBc; cl02129 471223008965 KorB domain; Region: KorB; pfam08535 471223008966 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 471223008967 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 471223008968 P-loop; other site 471223008969 Magnesium ion binding site [ion binding]; other site 471223008970 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 471223008971 Magnesium ion binding site [ion binding]; other site 471223008972 Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475 471223008973 ParB-like nuclease domain; Region: ParBc; cl02129 471223008974 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl15754 471223008975 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 471223008976 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 471223008977 GidA associated domain 3; Region: GIDA_assoc_3; pfam13932 471223008978 tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291 471223008979 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 471223008980 trmE is a tRNA modification GTPase; Region: trmE; cd04164 471223008981 G1 box; other site 471223008982 GTP/Mg2+ binding site [chemical binding]; other site 471223008983 Switch I region; other site 471223008984 G2 box; other site 471223008985 Switch II region; other site 471223008986 G3 box; other site 471223008987 G4 box; other site 471223008988 G5 box; other site 471223008989 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 471223008990 Predicted RNA-binding protein [General function prediction only]; Region: Jag; COG1847 471223008991 jag_K homology RNA-binding domain. The KH domain is found in proteins homologous to the Bacillus subtilis protein Jag, which is associated with SpoIIIJ and is necessary for the third stage of sporulation. The KH motif is a beta-alpha-alpha-beta-beta...; Region: jag_KH; cd02414 471223008992 G-X-X-G motif; other site 471223008993 R3H domain found in proteins homologous to Bacillus subtilus Jag, which is associated with SpoIIIJ. SpoIIIJ is necessary for the third stage of sporulation. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine...; Region: R3H_jag; cd02644 471223008994 RxxxH motif; other site 471223008995 60Kd inner membrane protein; Region: 60KD_IMP; cl00489 471223008996 Transposase domain (DUF772); Region: DUF772; cl15789 471223008997 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 471223008998 Ribonuclease P; Region: Ribonuclease_P; cl00457 471223008999 Ribosomal protein L34; Region: Ribosomal_L34; cl00370 471223009000 Protein of unknown function (DUF3006); Region: DUF3006; pfam11213 471223009001 YolD-like protein; Region: YolD; pfam08863 471223009002 DNA polymerase IV; Reviewed; Region: PRK03103 471223009003 umuC subunit of DNA Polymerase V; Region: PolY_Pol_V_umuC; cd01700 471223009004 active site 471223009005 DNA binding site [nucleotide binding] 471223009006 Domain of unknown function (DUF4113); Region: DUF4113; pfam13438 471223009007 N-6 DNA Methylase; Region: N6_Mtase; pfam02384 471223009008 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 471223009009 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 471223009010 Type I restriction-modification system methyltransferase subunit [Defense mechanisms]; Region: HsdM; COG0286 471223009011 HsdM N-terminal domain; Region: HsdM_N; pfam12161 471223009012 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 471223009013 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 471223009014 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 471223009015 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 471223009016 Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: COG0610 471223009017 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; cl14958 471223009018 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 471223009019 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 471223009020 tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224 471223009021 DNA binding site [nucleotide binding] 471223009022 Int/Topo IB signature motif; other site 471223009023 active site 471223009024 Transposase, Mutator family; Region: Transposase_mut; pfam00872 471223009025 MULE transposase domain; Region: MULE; pfam10551 471223009026 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; cl14891 471223009027 Integrase core domain; Region: rve; cl01316 471223009028 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 471223009029 ATP binding site [chemical binding]; other site 471223009030 putative Mg++ binding site [ion binding]; other site 471223009031 Initiator Replication protein; Region: Rep_3; cl03080 471223009032 INT_SG3, DNA breaking-rejoining enzymes, integrase/recombinases subgroup 3, catalytic domain. The CD contains various predicted bacterial and phage integrase/recombinase sequences for which not much experimental characterization is available; Region: INT_SG3_C; cd01186 471223009033 Int/Topo IB signature motif; other site 471223009034 D-ala-D-ala dipeptidase; Region: Peptidase_M15; cl00813 471223009035 YvrJ protein family; Region: YvrJ; pfam12841 471223009036 Protein of unknown function (DUF2922); Region: DUF2922; pfam11148 471223009037 Protein of unknown function (DUF1659); Region: DUF1659; pfam07872 471223009038 Ribbon-helix-helix protein, copG family; Region: RHH_1; cl15783 471223009039 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 471223009040 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 471223009041 P-loop; other site 471223009042 Magnesium ion binding site [ion binding]; other site 471223009043 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 471223009044 Magnesium ion binding site [ion binding]; other site 471223009045 Primase C terminal 1 (PriCT-1); Region: PriCT_1; cl07362 471223009046 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446