-- dump date   	20120504_145241
-- class       	Genbank::misc_feature
-- table       	misc_feature_note
-- id	note
243231000001	chromosomal replication initiation protein; Reviewed; Region: dnaA; PRK00149
243231000002	DnaA N-terminal domain; Region: DnaA_N; pfam11638
243231000003	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
243231000004	Walker A motif; other site
243231000005	ATP binding site [chemical binding]; other site
243231000006	Walker B motif; other site
243231000007	arginine finger; other site
243231000008	C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571
243231000009	DnaA box-binding interface [nucleotide binding]; other site
243231000010	DNA polymerase III subunit beta; Validated; Region: PRK05643
243231000011	Beta clamp domain.  The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria.  The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140
243231000012	putative DNA binding surface [nucleotide binding]; other site
243231000013	dimer interface [polypeptide binding]; other site
243231000014	beta-clamp/clamp loader binding surface; other site
243231000015	beta-clamp/translesion DNA polymerase binding surface; other site
243231000016	recombination protein F; Reviewed; Region: recF; PRK00064
243231000017	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
243231000018	Walker A/P-loop; other site
243231000019	ATP binding site [chemical binding]; other site
243231000020	Q-loop/lid; other site
243231000021	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
243231000022	ABC transporter signature motif; other site
243231000023	Walker B; other site
243231000024	D-loop; other site
243231000025	H-loop/switch region; other site
243231000026	DNA gyrase subunit B; Provisional; Region: gyrB; PRK14939
243231000027	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
243231000028	Mg2+ binding site [ion binding]; other site
243231000029	G-X-G motif; other site
243231000030	TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822
243231000031	anchoring element; other site
243231000032	dimer interface [polypeptide binding]; other site
243231000033	ATP binding site [chemical binding]; other site
243231000034	TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366
243231000035	active site
243231000036	putative metal-binding site [ion binding]; other site
243231000037	DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986
243231000038	DNA gyrase subunit A; Validated; Region: PRK05560
243231000039	DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes in DNA...; Region: TOP4c; cd00187
243231000040	CAP-like domain; other site
243231000041	active site
243231000042	primary dimer interface [polypeptide binding]; other site
243231000043	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
243231000044	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
243231000045	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
243231000046	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
243231000047	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
243231000048	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
243231000049	NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094
243231000050	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
243231000051	NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479
243231000052	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: VicK; COG5002
243231000053	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
243231000054	dimerization interface [polypeptide binding]; other site
243231000055	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
243231000056	putative active site [active]
243231000057	heme pocket [chemical binding]; other site
243231000058	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
243231000059	dimer interface [polypeptide binding]; other site
243231000060	phosphorylation site [posttranslational modification]
243231000061	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
243231000062	ATP binding site [chemical binding]; other site
243231000063	Mg2+ binding site [ion binding]; other site
243231000064	G-X-G motif; other site
243231000065	Response regulator receiver domain; Region: Response_reg; pfam00072
243231000066	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
243231000067	active site
243231000068	phosphorylation site [posttranslational modification]
243231000069	intermolecular recognition site; other site
243231000070	dimerization interface [polypeptide binding]; other site
243231000071	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
243231000072	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
243231000073	putative active site [active]
243231000074	heme pocket [chemical binding]; other site
243231000075	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
243231000076	dimer interface [polypeptide binding]; other site
243231000077	phosphorylation site [posttranslational modification]
243231000078	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
243231000079	ATP binding site [chemical binding]; other site
243231000080	Mg2+ binding site [ion binding]; other site
243231000081	G-X-G motif; other site
243231000082	PAS domain S-box; Region: sensory_box; TIGR00229
243231000083	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459
243231000084	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920
243231000085	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
243231000086	dimer interface [polypeptide binding]; other site
243231000087	phosphorylation site [posttranslational modification]
243231000088	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
243231000089	ATP binding site [chemical binding]; other site
243231000090	Mg2+ binding site [ion binding]; other site
243231000091	G-X-G motif; other site
243231000092	Response regulator receiver domain; Region: Response_reg; pfam00072
243231000093	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
243231000094	active site
243231000095	phosphorylation site [posttranslational modification]
243231000096	intermolecular recognition site; other site
243231000097	dimerization interface [polypeptide binding]; other site
243231000098	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459
243231000099	PAS domain; Region: PAS_9; pfam13426
243231000100	GAF domain; Region: GAF_2; pfam13185
243231000101	GAF domain; Region: GAF; cl15785
243231000102	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
243231000103	dimer interface [polypeptide binding]; other site
243231000104	phosphorylation site [posttranslational modification]
243231000105	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
243231000106	ATP binding site [chemical binding]; other site
243231000107	Mg2+ binding site [ion binding]; other site
243231000108	G-X-G motif; other site
243231000109	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
243231000110	daunorubicin resistance ABC transporter ATP-binding subunit; Region: drrA; TIGR01188
243231000111	Walker A/P-loop; other site
243231000112	ATP binding site [chemical binding]; other site
243231000113	Q-loop/lid; other site
243231000114	ABC transporter signature motif; other site
243231000115	Walker B; other site
243231000116	D-loop; other site
243231000117	H-loop/switch region; other site
243231000118	Domain of unknown function (DUF4162); Region: DUF4162; pfam13732
243231000119	protoporphyrinogen oxidase; Reviewed; Region: PRK11883
243231000120	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
243231000121	Transcriptional regulators [Transcription]; Region: MarR; COG1846
243231000122	Helix-turn-helix domains; Region: HTH; cl00088
243231000123	chaperone protein DnaJ; Provisional; Region: PRK14299
243231000124	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
243231000125	HSP70 interaction site [polypeptide binding]; other site
243231000126	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747
243231000127	substrate binding site [polypeptide binding]; other site
243231000128	dimer interface [polypeptide binding]; other site
243231000129	SurA N-terminal domain; Region: SurA_N_3; cl07813
243231000130	PPIC-type PPIASE domain; Region: Rotamase; cl08278
243231000131	SurA N-terminal domain; Region: SurA_N_3; cl07813
243231000132	peptidylprolyl isomerase; Provisional; Region: prsA; PRK04405
243231000133	PPIC-type PPIASE domain; Region: Rotamase; cl08278
243231000134	Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197
243231000135	CarD-like/TRCF domain; Region: CarD_CdnL_TRCF; cl00588
243231000136	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
243231000137	ATP binding site [chemical binding]; other site
243231000138	putative Mg++ binding site [ion binding]; other site
243231000139	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
243231000140	nucleotide binding region [chemical binding]; other site
243231000141	ATP-binding site [chemical binding]; other site
243231000142	TRCF domain; Region: TRCF; cl04088
243231000143	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167
243231000144	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
243231000145	DNA-binding site [nucleotide binding]; DNA binding site
243231000146	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
243231000147	pyridoxal 5'-phosphate binding site [chemical binding]; other site
243231000148	homodimer interface [polypeptide binding]; other site
243231000149	catalytic residue [active]
243231000150	Pentapeptide repeats containing protein [Function unknown]; Region: COG1357
243231000151	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
243231000152	Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663
243231000153	Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645
243231000154	trimer interface [polypeptide binding]; other site
243231000155	putative metal binding site [ion binding]; other site
243231000156	Quinolinate synthetase A protein; Region: NadA; cl00420
243231000157	mttA/Hcf106 family; Region: MttA_Hcf106; cl00788
243231000158	tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795
243231000159	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
243231000160	binding surface
243231000161	TPR motif; other site
243231000162	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
243231000163	ligand binding site [chemical binding]; other site
243231000164	tol-pal system beta propeller repeat protein TolB; Region: propeller_TolB; TIGR02800
243231000165	TolB amino-terminal domain; Region: TolB_N; cl00639
243231000166	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
243231000167	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567
243231000168	structural tetrad; other site
243231000169	Periplasmic protein TonB, links inner and outer membranes [Cell envelope biogenesis, outer membrane]; Region: TonB; COG0810
243231000170	Gram-negative bacterial tonB protein; Region: TonB; cl10048
243231000171	Biopolymer transport protein ExbD/TolR; Region: ExbD; cl00537
243231000172	MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568
243231000173	Predicted amidohydrolase [General function prediction only]; Region: COG0388
243231000174	Uncharacterized subgroup of the nitrilase superfamily (putative class 13 nitrilases); Region: nitrilase_5; cd07583
243231000175	putative active site [active]
243231000176	catalytic triad [active]
243231000177	putative dimer interface [polypeptide binding]; other site
243231000178	coproporphyrinogen III oxidase; Provisional; Region: PRK05799
243231000179	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
243231000180	FeS/SAM binding site; other site
243231000181	HemN C-terminal domain; Region: HemN_C; pfam06969
243231000182	heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082
243231000183	Helix-turn-helix domains; Region: HTH; cl00088
243231000184	GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446
243231000185	dimer interface [polypeptide binding]; other site
243231000186	hsp70 (ATPase domain) interactions [polypeptide binding]; other site
243231000187	molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290
243231000188	FGGY family of carbohydrate kinases; Region: FGGY; cl08364
243231000189	chaperone protein DnaJ; Provisional; Region: PRK10767
243231000190	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
243231000191	HSP70 interaction site [polypeptide binding]; other site
243231000192	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262
243231000193	substrate binding site [polypeptide binding]; other site
243231000194	Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719
243231000195	Zn binding sites [ion binding]; other site
243231000196	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747
243231000197	dimer interface [polypeptide binding]; other site
243231000198	2'-5' RNA ligase; Region: 2_5_ligase; TIGR02258
243231000199	LigT like Phosphoesterase; Region: LigT_PEase; pfam02834
243231000200	LigT like Phosphoesterase; Region: LigT_PEase; pfam02834
243231000201	Bacterial capsule synthesis protein PGA_cap; Region: PGA_cap; smart00854
243231000202	CapA and related proteins, metallophosphatase domain; Region: MPP_CapA; cd07381
243231000203	putative active site [active]
243231000204	putative metal binding site [ion binding]; other site
243231000205	seryl-tRNA synthetase; Provisional; Region: PRK05431
243231000206	Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403
243231000207	Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme bound...; Region: SerRS_core; cd00770
243231000208	dimer interface [polypeptide binding]; other site
243231000209	active site
243231000210	motif 1; other site
243231000211	motif 2; other site
243231000212	motif 3; other site
243231000213	Gsu32; element integrated into the tRNA-Arg-4 gene
243231000214	Uncharacterized ACR, COG2135; Region: DUF159; cl03646
243231000215	LexA repressor; Validated; Region: PRK00215
243231000216	Helix-turn-helix domains; Region: HTH; cl00088
243231000217	Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529
243231000218	Catalytic site [active]
243231000219	DNA polymerase IV; Reviewed; Region: PRK03103
243231000220	DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586
243231000221	active site
243231000222	DNA binding site [nucleotide binding]
243231000223	Insecticide toxin TcdB middle/N-terminal region; Region: TcdB_toxin_midN; pfam12256
243231000224	Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209
243231000225	RHS Repeat; Region: RHS_repeat; cl11982
243231000226	RHS Repeat; Region: RHS_repeat; cl11982
243231000227	RHS Repeat; Region: RHS_repeat; cl11982
243231000228	Early set domain associated with the catalytic domain of sugar utilizing enzymes at either the N or C terminus; Region: E_set; cl09101
243231000229	Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199
243231000230	RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696
243231000231	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584
243231000232	Integrase core domain; Region: rve; cl01316
243231000233	transposase/IS protein; Provisional; Region: PRK09183
243231000234	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
243231000235	Walker A motif; other site
243231000236	ATP binding site [chemical binding]; other site
243231000237	Walker B motif; other site
243231000238	HTH-like domain; Region: HTH_21; pfam13276
243231000239	Integrase core domain; Region: rve; cl01316
243231000240	DDE domain; Region: DDE_Tnp_IS240; pfam13610
243231000241	Integrase core domain; Region: rve_3; cl15866
243231000242	Predicted transcriptional regulator [Transcription]; Region: COG2378
243231000243	WYL domain; Region: WYL; cl14852
243231000244	HIRAN domain; Region: HIRAN; cl07418
243231000245	CRISPR/Cas system-associated protein Cas3; Distinct Cas3 family with HD domain fused to C-termus of Helicase domain; Region: Cas3_I; cd09696
243231000246	CRISPR-associated helicase Cas3, subtype Dpsyc; Region: cas3_GSU0051; TIGR02621
243231000247	CRISPR/Cas system-associated protein Csx14; Region: Csx14_I-U; cd09765
243231000248	CRISPR/Cas system-associated protein Csb1; Region: Csb1_I-U; cd09678
243231000249	CRISPR/Cas system-associated protein Csb2; Region: Csb2_I-U; cd09734
243231000250	Plasmid stabilisation system protein; Region: Plasmid_stabil; cl11422
243231000251	Putative addiction module component; Region: Unstab_antitox; cl09921
243231000252	CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641
243231000253	CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-II-III; cd09634
243231000254	CRISPR/Cas system-associated protein Cas2; Region: Cas2_I_II_III; cd09725
243231000255	Protein of unknown function (DUF3232); Region: DUF3232; pfam11554
243231000256	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
243231000257	Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600
243231000258	Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements.  They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801
243231000259	active site
243231000260	Int/Topo IB signature motif; other site
243231000261	Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285
243231000262	nucleoside/Zn binding site; other site
243231000263	dimer interface [polypeptide binding]; other site
243231000264	catalytic motif [active]
243231000265	Peroxiredoxin (PRX)-like 2 family; hypothetical proteins that show sequence similarity to PRXs. Members of this group contain a CXXC motif, similar to TRX. The second cysteine in the motif corresponds to the peroxidatic cysteine of PRX, however, these...; Region: PRX_like2; cd02970
243231000266	putative catalytic residues [active]
243231000267	Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeA; cd00883
243231000268	active site clefts [active]
243231000269	zinc binding site [ion binding]; other site
243231000270	dimer interface [polypeptide binding]; other site
243231000271	decaheme c-type cytochrome, DmsE family; Region: decahem_SO; TIGR03508
243231000272	tetrathionate reductase subunit B; Provisional; Region: PRK14993
243231000273	Polysulphide reductase, NrfD; Region: NrfD; cl01295
243231000274	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl01155
243231000275	isoprenoid biosynthesis protein with amidotransferase-like domain; Provisional; Region: PRK11780
243231000276	Type 1 glutamine amidotransferase (GATase1)-like domain found in zebrafish ES1; Region: GATase1_ES1; cd03133
243231000277	conserved cys residue [active]
243231000278	atypical (a) SDRs, subgroup 2; Region: SDR_a2; cd05245
243231000279	Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702
243231000280	putative NAD(P) binding site [chemical binding]; other site
243231000281	putative active site [active]
243231000282	PilZ domain; Region: PilZ; cl01260
243231000283	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
243231000284	non-specific DNA binding site [nucleotide binding]; other site
243231000285	salt bridge; other site
243231000286	sequence-specific DNA binding site [nucleotide binding]; other site
243231000287	Cupin domain; Region: Cupin_2; cl09118
243231000288	periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037
243231000289	Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149
243231000290	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
243231000291	protein binding site [polypeptide binding]; other site
243231000292	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
243231000293	protein binding site [polypeptide binding]; other site
243231000294	pseudouridine synthase, RluA family; Region: rluA_subfam; TIGR00005
243231000295	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
243231000296	RNA binding surface [nucleotide binding]; other site
243231000297	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
243231000298	active site
243231000299	Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496
243231000300	Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; cl00650
243231000301	hypothetical protein; Provisional; Region: PRK07550
243231000302	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
243231000303	pyridoxal 5'-phosphate binding site [chemical binding]; other site
243231000304	homodimer interface [polypeptide binding]; other site
243231000305	catalytic residue [active]
243231000306	cytochrome-c3 hydrogenase subunit gamma; Provisional; Region: PRK08345
243231000307	Anaerobic sulfite reductase contains an FAD and NADPH binding module with structural similarity to ferredoxin reductase and sequence similarity to dihydroorotate dehydrogenases. Clostridium pasteurianum inducible dissimilatory type sulfite reductase is...; Region: sulfite_reductase_like; cd06221
243231000308	FAD binding pocket [chemical binding]; other site
243231000309	FAD binding motif [chemical binding]; other site
243231000310	phosphate binding motif [ion binding]; other site
243231000311	beta-alpha-beta structure motif; other site
243231000312	NAD binding pocket [chemical binding]; other site
243231000313	Iron coordination center [ion binding]; other site
243231000314	sulfite reductase, subunit A; Region: sulfite_red_A; TIGR02910
243231000315	4Fe-4S binding domain; Region: Fer4; cl02805
243231000316	Coenzyme F420-reducing hydrogenase, beta subunit [Energy production and conversion]; Region: FrhB; COG1035
243231000317	Coenzyme F420 hydrogenase/dehydrogenase, beta subunit C terminus; Region: FrhB_FdhB_C; pfam04432
243231000318	sulfite reductase, subunit A; Region: sulfite_red_A; TIGR02910
243231000319	4Fe-4S dicluster domain; Region: Fer4_18; pfam13746
243231000320	Methyl-viologen-reducing hydrogenase, delta subunit; Region: FlpD; cl00831
243231000321	Heterodisulfide reductase, subunit A and related polyferredoxins [Energy production and conversion]; Region: HdrA; COG1148
243231000322	4Fe-4S binding domain; Region: Fer4; cl02805
243231000323	Heterodisulfide reductase, subunit B [Energy production and conversion]; Region: HdrB; COG2048
243231000324	Cysteine-rich domain; Region: CCG; pfam02754
243231000325	Cysteine-rich domain; Region: CCG; pfam02754
243231000326	Heterodisulfide reductase, subunit C [Energy production and conversion]; Region: HdrC; COG1150
243231000327	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
243231000328	ABC transporter transmembrane region; Region: ABC_membrane; cl00549
243231000329	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
243231000330	Walker A/P-loop; other site
243231000331	ATP binding site [chemical binding]; other site
243231000332	Q-loop/lid; other site
243231000333	ABC transporter signature motif; other site
243231000334	Walker B; other site
243231000335	D-loop; other site
243231000336	H-loop/switch region; other site
243231000337	DNA polymerase III subunits gamma and tau; Provisional; Region: PRK14965
243231000338	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
243231000339	Walker A motif; other site
243231000340	ATP binding site [chemical binding]; other site
243231000341	Walker B motif; other site
243231000342	arginine finger; other site
243231000343	DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169
243231000344	Uncharacterized conserved protein [Function unknown]; Region: COG1615; cl09133
243231000345	YbaB/EbfC DNA-binding family; Region: YbaB_DNA_bd; cl00494
243231000346	recombination protein RecR; Reviewed; Region: recR; PRK00076
243231000347	RecR protein; Region: RecR; pfam02132
243231000348	TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR.  RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025
243231000349	putative active site [active]
243231000350	putative metal-binding site [ion binding]; other site
243231000351	tetramer interface [polypeptide binding]; other site
243231000352	pyruvate:ferredoxin (flavodoxin) oxidoreductase, homodimeric; Region: pyruv_ox_red; TIGR02176
243231000353	Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034
243231000354	dimer interface [polypeptide binding]; other site
243231000355	PYR/PP interface [polypeptide binding]; other site
243231000356	TPP binding site [chemical binding]; other site
243231000357	substrate binding site [chemical binding]; other site
243231000358	Pyruvate ferredoxin/flavodoxin oxidoreductase; Region: POR; cl00546
243231000359	Domain of unknown function; Region: EKR; cl11037
243231000360	4Fe-4S binding domain; Region: Fer4; cl02805
243231000361	Thiamine pyrophosphate (TPP family), PFOR_PNO subfamily, TPP-binding module; composed of proteins similar to the single subunit pyruvate ferredoxin oxidoreductase (PFOR) of Desulfovibrio Africanus, present in bacteria and amitochondriate eukaryotes. This...; Region: TPP_PFOR_PNO; cd03377
243231000362	TPP-binding site [chemical binding]; other site
243231000363	dimer interface [polypeptide binding]; other site
243231000364	Roadblock/LC7 domain; Region: Robl_LC7; cl00886
243231000365	Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882
243231000366	G1 box; other site
243231000367	GTP/Mg2+ binding site [chemical binding]; other site
243231000368	G2 box; other site
243231000369	Switch I region; other site
243231000370	G3 box; other site
243231000371	Switch II region; other site
243231000372	G4 box; other site
243231000373	G5 box; other site
243231000374	ABC transporter transmembrane region; Region: ABC_membrane; cl00549
243231000375	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
243231000376	Glucan exporter ATP-binding protein.  In A. tumefaciens cyclic beta-1, 2-glucan must be transported into the periplasmic space to exert its action as a virluence factor.  This subfamily belongs to the MRP-like family and is involved in drug, peptide, and...; Region: ABCC_Glucan_exporter_like; cd03254
243231000377	Walker A/P-loop; other site
243231000378	ATP binding site [chemical binding]; other site
243231000379	Q-loop/lid; other site
243231000380	ABC transporter signature motif; other site
243231000381	Walker B; other site
243231000382	D-loop; other site
243231000383	H-loop/switch region; other site
243231000384	selenocysteinyl-tRNA-specific translation factor; Provisional; Region: PRK10512
243231000385	SelB, the dedicated elongation factor for delivery of selenocysteinyl-tRNA to the ribosome; Region: SelB; cd04171
243231000386	G1 box; other site
243231000387	putative GEF interaction site [polypeptide binding]; other site
243231000388	GTP/Mg2+ binding site [chemical binding]; other site
243231000389	Switch I region; other site
243231000390	G2 box; other site
243231000391	G3 box; other site
243231000392	Switch II region; other site
243231000393	G4 box; other site
243231000394	G5 box; other site
243231000395	selB_II: this subfamily represents the domain of elongation factor SelB, homologous to domain II of EF-Tu. SelB may function by replacing EF-Tu. In prokaryotes, the incorporation of selenocysteine as the 21st amino acid, encoded by TGA, requires several...; Region: selB_II; cd03696
243231000396	This family represents the domain of elongation factor SelB, homologous to domain III of EF-Tu. SelB may function by replacing EF-Tu. In prokaryotes, the incorporation of selenocysteine as the 21st amino acid, encoded by TGA, requires several elements:...; Region: selB_III; cd04094
243231000397	Elongation factor SelB, winged helix; Region: SelB-wing_2; pfam09106
243231000398	Elongation factor SelB, winged helix; Region: SelB-wing_3; pfam09107
243231000399	sensory histidine kinase AtoS; Provisional; Region: PRK11360
243231000400	PAS fold; Region: PAS_4; pfam08448
243231000401	Bacteriophytochrome (light-regulated signal transduction histidine kinase) [Signal transduction mechanisms]; Region: COG4251
243231000402	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
243231000403	ATP binding site [chemical binding]; other site
243231000404	Mg2+ binding site [ion binding]; other site
243231000405	G-X-G motif; other site
243231000406	Response regulator receiver domain; Region: Response_reg; pfam00072
243231000407	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
243231000408	active site
243231000409	phosphorylation site [posttranslational modification]
243231000410	intermolecular recognition site; other site
243231000411	dimerization interface [polypeptide binding]; other site
243231000412	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
243231000413	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
243231000414	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
243231000415	Magnesium ion binding site [ion binding]; other site
243231000416	ParB-like partition proteins; Region: parB_part; TIGR00180
243231000417	ParB-like nuclease domain; Region: ParBc; cl02129
243231000418	Helix-turn-helix domains; Region: HTH; cl00088
243231000419	F0F1 ATP synthase subunit B'; Validated; Region: PRK07353
243231000420	ATP synthase B/B' CF(0); Region: ATP-synt_B; cl07975
243231000421	ATP synthase B/B' CF(0); Region: ATP-synt_B; cl07975
243231000422	ATP synthase B/B' CF(0); Region: ATP-synt_B; cl07975
243231000423	ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213
243231000424	F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281
243231000425	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; cl15275
243231000426	F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132
243231000427	beta subunit interaction interface [polypeptide binding]; other site
243231000428	Walker A motif; other site
243231000429	ATP binding site [chemical binding]; other site
243231000430	Walker B motif; other site
243231000431	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
243231000432	ATP synthase; Region: ATP-synt; cl00365
243231000433	F0F1 ATP synthase subunit gamma; Provisional; Region: PRK13422
243231000434	F0F1 ATP synthase subunit beta; Validated; Region: PRK09280
243231000435	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; cl15275
243231000436	F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133
243231000437	alpha subunit interaction interface [polypeptide binding]; other site
243231000438	Walker A motif; other site
243231000439	ATP binding site [chemical binding]; other site
243231000440	Walker B motif; other site
243231000441	inhibitor binding site; inhibition site
243231000442	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
243231000443	F0F1 ATP synthase subunit epsilon; Provisional; Region: atpC; PRK13446
243231000444	ATP synthase, Delta/Epsilon chain, beta-sandwich domain; Region: ATP-synt_DE_N; cl10033
243231000445	4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK03743
243231000446	Pyridoxal phosphate biosynthetic protein PdxA; Region: PdxA; cl00873
243231000447	Transglycosylase; Region: Transgly; cl07896
243231000448	Aspartate/tyrosine/aromatic aminotransferase [Amino acid transport and metabolism]; Region: COG0436
243231000449	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
243231000450	pyridoxal 5'-phosphate binding site [chemical binding]; other site
243231000451	homodimer interface [polypeptide binding]; other site
243231000452	catalytic residue [active]
243231000453	siderophore ferric iron reductase, AHA_1954 family; Region: sidero_Fe_reduc; TIGR03950
243231000454	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
243231000455	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587
243231000456	active site
243231000457	Endopeptidases belonging to membrane-bound hydrogenases group. These hydrogenases transfer electrons from H2 to a cytochrome that is bound to a membrane-located complex coupling electron transfer to transmembrane proton translocation. Endopeptidase HybD...; Region: H2MP_MemB-H2up; cd06062
243231000458	coenzyme F420-reducing hydrogenase delta subunit (putative coenzyme F420 hydrogenase processing subunit); Region: frhD; TIGR00130
243231000459	putative substrate-binding site; other site
243231000460	nickel binding site [ion binding]; other site
243231000461	Cytochrome b (N-terminus)/b6/petB:  Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859
243231000462	Nickel-dependent hydrogenase; Region: NiFeSe_Hases; cl00417
243231000463	Ni,Fe-hydrogenase I small subunit [Energy production and conversion]; Region: HyaA; COG1740
243231000464	Tat (twin-arginine translocation) pathway signal sequence; Region: TAT_signal_seq; TIGR01409
243231000465	NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; cl15792
243231000466	Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040
243231000467	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
243231000468	active site
243231000469	Uncharacterized ACR, YkgG family COG1556; Region: DUF162; cl00674
243231000470	Polyferredoxin [Energy production and conversion]; Region: NapH; COG0348
243231000471	4Fe-4S binding domain; Region: Fer4_5; pfam12801
243231000472	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
243231000473	tRNA 2-thiocytidine biosynthesis protein TtcA; Provisional; Region: PRK10696
243231000474	This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily  includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which  binds to Adenosine group.  This subfamily; Region: Alpha_ANH_like_II; cd01993
243231000475	Ligand Binding Site [chemical binding]; other site
243231000476	TIGR00269 family protein; Region: TIGR00269
243231000477	primosome assembly protein PriA; Validated; Region: PRK05580
243231000478	primosome assembly protein PriA; Validated; Region: PRK05580
243231000479	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
243231000480	ATP binding site [chemical binding]; other site
243231000481	putative Mg++ binding site [ion binding]; other site
243231000482	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
243231000483	Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487
243231000484	active site
243231000485	catalytic residues [active]
243231000486	metal binding site [ion binding]; metal-binding site
243231000487	methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005
243231000488	Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646
243231000489	putative active site [active]
243231000490	substrate binding site [chemical binding]; other site
243231000491	putative cosubstrate binding site; other site
243231000492	catalytic site [active]
243231000493	C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704
243231000494	substrate binding site [chemical binding]; other site
243231000495	Protein of unknown function DUF116; Region: DUF116; cl00800
243231000496	Chemotaxis phosphatase CheX; Region: CheX; cl15816
243231000497	Putative exonuclease, RdgC; Region: RdgC; cl01122
243231000498	Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446
243231000499	Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cd00384
243231000500	dimer interface [polypeptide binding]; other site
243231000501	active site
243231000502	Schiff base residues; other site
243231000503	DoxX; Region: DoxX; cl00976
243231000504	PilZ domain; Region: PilZ; cl01260
243231000505	peptide chain release factor 3; Provisional; Region: prfC; PRK00741
243231000506	Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169
243231000507	G1 box; other site
243231000508	putative GEF interaction site [polypeptide binding]; other site
243231000509	GTP/Mg2+ binding site [chemical binding]; other site
243231000510	Switch I region; other site
243231000511	G2 box; other site
243231000512	G3 box; other site
243231000513	Switch II region; other site
243231000514	G4 box; other site
243231000515	G5 box; other site
243231000516	RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689
243231000517	NCAIR mutase (PurE)-related proteins [General function prediction only]; Region: COG1691
243231000518	AIR carboxylase; Region: AIRC; cl00310
243231000519	Protein of unknown function DUF111; Region: DUF111; cl03398
243231000520	Phosphatidylglycerophosphatase A; a bacterial membrane-associated enzyme involved in lipid metabolism; Region: PgpA; cd06971
243231000521	tetramer interfaces [polypeptide binding]; other site
243231000522	binuclear metal-binding site [ion binding]; other site
243231000523	competence damage-inducible protein A; Provisional; Region: PRK00549
243231000524	Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885
243231000525	putative MPT binding site; other site
243231000526	Competence-damaged protein; Region: CinA; cl00666
243231000527	PAS domain S-box; Region: sensory_box; TIGR00229
243231000528	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459
243231000529	GAF domain; Region: GAF_2; pfam13185
243231000530	GAF domain; Region: GAF; cl15785
243231000531	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
243231000532	dimer interface [polypeptide binding]; other site
243231000533	phosphorylation site [posttranslational modification]
243231000534	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
243231000535	ATP binding site [chemical binding]; other site
243231000536	Mg2+ binding site [ion binding]; other site
243231000537	G-X-G motif; other site
243231000538	recombinase A; Provisional; Region: recA; PRK09354
243231000539	RecA is a  bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response.  RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983
243231000540	hexamer interface [polypeptide binding]; other site
243231000541	Walker A motif; other site
243231000542	ATP binding site [chemical binding]; other site
243231000543	Walker B motif; other site
243231000544	pilus retraction protein PilT; Region: pilT_fam; TIGR01420
243231000545	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
243231000546	Walker A motif; other site
243231000547	ATP binding site [chemical binding]; other site
243231000548	Walker B motif; other site
243231000549	RecX family; Region: RecX; cl00936
243231000550	alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252
243231000551	Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent formation of...; Region: AlaRS_core; cd00673
243231000552	motif 1; other site
243231000553	active site
243231000554	motif 2; other site
243231000555	motif 3; other site
243231000556	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; cl08469
243231000557	Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; Region: SPEC; cl02488
243231000558	DHHA1 domain; Region: DHHA1; pfam02272
243231000559	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
243231000560	active site
243231000561	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
243231000562	phosphorylation site [posttranslational modification]
243231000563	intermolecular recognition site; other site
243231000564	dimerization interface [polypeptide binding]; other site
243231000565	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
243231000566	dimer interface [polypeptide binding]; other site
243231000567	phosphorylation site [posttranslational modification]
243231000568	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
243231000569	ATP binding site [chemical binding]; other site
243231000570	Mg2+ binding site [ion binding]; other site
243231000571	G-X-G motif; other site
243231000572	AAK_NAGK-C: N-Acetyl-L-glutamate kinase - cyclic (NAGK-C) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine biosynthesis found in some bacteria and photosynthetic organisms using the...; Region: AAK_NAGK-C; cd04250
243231000573	feedback inhibition sensing region; other site
243231000574	homohexameric interface [polypeptide binding]; other site
243231000575	nucleotide binding site [chemical binding]; other site
243231000576	N-acetyl-L-glutamate binding site [chemical binding]; other site
243231000577	acetylornithine aminotransferase; Provisional; Region: PRK02627
243231000578	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
243231000579	inhibitor-cofactor binding pocket; inhibition site
243231000580	pyridoxal 5'-phosphate binding site [chemical binding]; other site
243231000581	catalytic residue [active]
243231000582	ornithine carbamoyltransferase; Provisional; Region: PRK00779
243231000583	Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729
243231000584	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
243231000585	Argininosuccinate synthase [Amino acid transport and metabolism]; Region: ArgG; COG0137
243231000586	Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate .  In...; Region: Argininosuccinate_Synthase; cd01999
243231000587	ANP binding site [chemical binding]; other site
243231000588	Substrate Binding Site II [chemical binding]; other site
243231000589	Substrate Binding Site I [chemical binding]; other site
243231000590	Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_15; cd04673
243231000591	nudix motif; other site
243231000592	argininosuccinate lyase; Provisional; Region: PRK00855
243231000593	Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359
243231000594	active sites [active]
243231000595	tetramer interface [polypeptide binding]; other site
243231000596	Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cl00065
243231000597	diaminopimelate decarboxylase; Region: lysA; TIGR01048
243231000598	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828
243231000599	active site
243231000600	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
243231000601	substrate binding site [chemical binding]; other site
243231000602	catalytic residues [active]
243231000603	dimer interface [polypeptide binding]; other site
243231000604	Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950
243231000605	dihydrodipicolinate synthase; Region: dapA; TIGR00674
243231000606	dimer interface [polypeptide binding]; other site
243231000607	active site
243231000608	catalytic residue [active]
243231000609	dihydrodipicolinate reductase; Provisional; Region: PRK00048
243231000610	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
243231000611	Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173
243231000612	LL-diaminopimelate aminotransferase; Region: DAPAT_plant; TIGR03542
243231000613	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
243231000614	pyridoxal 5'-phosphate binding site [chemical binding]; other site
243231000615	homodimer interface [polypeptide binding]; other site
243231000616	catalytic residue [active]
243231000617	Predicted transcriptional regulator [Transcription]; Region: COG4190
243231000618	Helix-turn-helix domains; Region: HTH; cl00088
243231000619	Uncharacterized conserved protein [Function unknown]; Region: COG4938
243231000620	Protein of unknown function (DUF3696); Region: DUF3696; pfam12476
243231000621	Transposase IS200 like; Region: Y1_Tnp; cl00848
243231000622	Fic family protein [Function unknown]; Region: COG3177
243231000623	Fic/DOC family N-terminal; Region: Fic_N; pfam13784
243231000624	Fic/DOC family; Region: Fic; cl00960
243231000625	Helix-turn-helix domains; Region: HTH; cl00088
243231000626	ABC transporter ATP-binding protein; Provisional; Region: PRK15064
243231000627	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
243231000628	Walker A/P-loop; other site
243231000629	ATP binding site [chemical binding]; other site
243231000630	Q-loop/lid; other site
243231000631	ABC transporter signature motif; other site
243231000632	Walker B; other site
243231000633	D-loop; other site
243231000634	H-loop/switch region; other site
243231000635	ABC transporter; Region: ABC_tran_2; pfam12848
243231000636	ABCF_EF-3  Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth.  EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221
243231000637	Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272
243231000638	Uncharacterized BCR, YaiI/YqxD family COG1671; Region: DUF188; cl00727
243231000639	N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247
243231000640	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
243231000641	Cupin superfamily (DUF985); Region: Cupin_5; cl01418
243231000642	Acetyl-CoA hydrolase/transferase N-terminal domain; Region: AcetylCoA_hydro; pfam02550
243231000643	succinate CoA transferases; Region: YgfH_subfam; TIGR03458
243231000644	SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339
243231000645	pyrimidine utilization regulatory protein R; Region: RutR; TIGR03613
243231000646	Helix-turn-helix domains; Region: HTH; cl00088
243231000647	Domain of unknown function (DUF1992); Region: DUF1992; cl08096
243231000648	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
243231000649	Coenzyme A binding pocket [chemical binding]; other site
243231000650	N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357
243231000651	Helix-turn-helix domains; Region: HTH; cl00088
243231000652	NADPH-dependent FMN reductase; Region: FMN_red; cl00438
243231000653	Protein of unknown function DUF45; Region: DUF45; cl00636
243231000654	TPR repeat; Region: TPR_11; pfam13414
243231000655	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
243231000656	binding surface
243231000657	TPR motif; other site
243231000658	L,D-transpeptidase catalytic domain; Region: YkuD; cl15405
243231000659	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
243231000660	L,D-transpeptidase catalytic domain; Region: YkuD; cl15405
243231000661	Sporulation related domain; Region: SPOR; cl10051
243231000662	Predicted phosphatases [General function prediction only]; Region: Gph; COG0546
243231000663	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
243231000664	motif II; other site
243231000665	Major Facilitator Superfamily; Region: MFS_1; pfam07690
243231000666	Predicted transcriptional regulator containing an HTH domain fused to a Zn-ribbon [Transcription]; Region: COG3357
243231000667	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
243231000668	ATP-dependent RNA helicase DbpA; Provisional; Region: PRK11776
243231000669	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
243231000670	ATP binding site [chemical binding]; other site
243231000671	Mg++ binding site [ion binding]; other site
243231000672	motif III; other site
243231000673	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
243231000674	nucleotide binding region [chemical binding]; other site
243231000675	ATP-binding site [chemical binding]; other site
243231000676	DbpA RNA binding domain; Region: DbpA; pfam03880
243231000677	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box protein; Region: CSP_CDS; cd04458
243231000678	DNA-binding site [nucleotide binding]; DNA binding site
243231000679	RNA-binding motif; other site
243231000680	Glucose/sorbosone dehydrogenases [Carbohydrate transport and metabolism]; Region: COG2133
243231000681	ADP-ribosylglycohydrolase; Region: ADP_ribosyl_GH; cl00614
243231000682	Dodecin; Region: Dodecin; cl01328
243231000683	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
243231000684	CoenzymeA binding site [chemical binding]; other site
243231000685	subunit interaction site [polypeptide binding]; other site
243231000686	PHB binding site; other site
243231000687	Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221
243231000688	classical (c) SDR, subgroup 5; Region: SDR_c5; cd05346
243231000689	putative NAD(P) binding site [chemical binding]; other site
243231000690	homodimer interface [polypeptide binding]; other site
243231000691	homotetramer interface [polypeptide binding]; other site
243231000692	active site
243231000693	Protein of unknown function (DUF3750); Region: DUF3750; pfam12570
243231000694	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
243231000695	catalytic loop [active]
243231000696	iron binding site [ion binding]; other site
243231000697	[2Fe-2S] binding domain; Region: Fer2_2; pfam01799
243231000698	Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529
243231000699	Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; cl03161
243231000700	Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738
243231000701	Xanthine and CO dehydrogenases maturation factor, XdhC/CoxF family [Posttranslational modification, protein turnover, chaperones]; Region: XdhC; COG1975
243231000702	XdhC and CoxI family; Region: XdhC_CoxI; pfam02625
243231000703	XdhC Rossmann domain; Region: XdhC_C; pfam13478
243231000704	GT_2_like_f is a subfamily of the glycosyltransferase family 2 (GT-2) with unknown function; Region: GT_2_like_f; cd04182
243231000705	molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317
243231000706	Ligand binding site; other site
243231000707	metal-binding site
243231000708	B12 binding domain_like associated with radical SAM domain. This domain shows similarity with B12 (adenosylcobamide) binding domains found in several enzymes, such as glutamate mutase, methionine synthase and methylmalonyl-CoA mutase, but it lacks the...; Region: radical_SAM_B12_BD; cd02068
243231000709	Elongator protein 3, MiaB family, Radical SAM; Region: Elp3; smart00729
243231000710	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cl15377
243231000711	FeS/SAM binding site; other site
243231000712	Helix-turn-helix domains; Region: HTH; cl00088
243231000713	Bacterial transcriptional repressor; Region: TetR; pfam13972
243231000714	Predicted divalent heavy-metal cations transporter [Inorganic ion transport and metabolism]; Region: COG0428; cl00437
243231000715	ZIP Zinc transporter; Region: Zip; pfam02535
243231000716	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box protein; Region: CSP_CDS; cd04458
243231000717	DNA-binding site [nucleotide binding]; DNA binding site
243231000718	RNA-binding motif; other site
243231000719	Domain of unknown function (DUF4350); Region: DUF4350; pfam14258
243231000720	Type I periplasmic ligand-binding domain of uncharacterized ABC-type transport systems that are predicted to be involved in the uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_uncharacterized_transporter; cd06325
243231000721	Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407
243231000722	zinc binding site [ion binding]; other site
243231000723	putative ligand binding site [chemical binding]; other site
243231000724	Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cd06574
243231000725	TM-ABC transporter signature motif; other site
243231000726	ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: PhnK; COG1101
243231000727	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
243231000728	Walker A/P-loop; other site
243231000729	ATP binding site [chemical binding]; other site
243231000730	Q-loop/lid; other site
243231000731	ABC transporter signature motif; other site
243231000732	Walker B; other site
243231000733	D-loop; other site
243231000734	H-loop/switch region; other site
243231000735	Elongator protein 3, MiaB family, Radical SAM; Region: Elp3; smart00729
243231000736	Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG2607
243231000737	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
243231000738	Walker A motif; other site
243231000739	ATP binding site [chemical binding]; other site
243231000740	Walker B motif; other site
243231000741	bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14190
243231000742	Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763
243231000743	NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080
243231000744	homodimer interface [polypeptide binding]; other site
243231000745	NADP binding site [chemical binding]; other site
243231000746	substrate binding site [chemical binding]; other site
243231000747	Nitroreductase-like family 3. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_3; cd02139
243231000748	putative FMN binding site [chemical binding]; other site
243231000749	SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968
243231000750	Cu(I) binding site [ion binding]; other site
243231000751	Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843
243231000752	Heme-copper oxidase subunit I.  Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which catalyze the reduction of O2 and simultaneously pump protons across the membrane.  The superfamily is...; Region: Heme_Cu_Oxidase_I; cl00275
243231000753	D-pathway; other site
243231000754	Low-spin heme binding site [chemical binding]; other site
243231000755	Putative water exit pathway; other site
243231000756	Binuclear center (active site) [active]
243231000757	K-pathway; other site
243231000758	Putative proton exit pathway; other site
243231000759	NorE_like subfamily of heme-copper oxidase subunit III.  Heme-copper oxidases include cytochrome c and ubiquinol oxidases.  Alcaligenes faecalis norE is found in a gene cluster containing norCB. norCB encodes the cytochrome c and cytochrome b subunits of...; Region: NorE_like; cd02862
243231000760	Subunit I/III interface [polypeptide binding]; other site
243231000761	Prokaryotic Cytochrome C oxidase subunit IV; Region: COX4_pro; cl01204
243231000762	cytochrome c oxidase, subunit II; Region: CoxB; TIGR02866
243231000763	Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; cl11412
243231000764	UbiA prenyltransferase family; Region: UbiA; cl00337
243231000765	Cupin domain; Region: Cupin_2; cl09118
243231000766	L-lactate permease; Region: Lactate_perm; cl00701
243231000767	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911
243231000768	Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dcm; COG0270
243231000769	cofactor binding site; other site
243231000770	DNA binding site [nucleotide binding]
243231000771	substrate interaction site [chemical binding]; other site
243231000772	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; cl11587
243231000773	long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187
243231000774	AMP-binding enzyme; Region: AMP-binding; cl15778
243231000775	pilus retraction protein PilT; Region: pilT_fam; TIGR01420
243231000776	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
243231000777	Walker A motif; other site
243231000778	ATP binding site [chemical binding]; other site
243231000779	Walker B motif; other site
243231000780	Domain of unknown function (DUF4388); Region: DUF4388; pfam14332
243231000781	hypothetical protein; Provisional; Region: PRK11239
243231000782	Protein of unknown function, DUF480; Region: DUF480; cl01209
243231000783	Formate/nitrite transporter; Region: Form_Nir_trans; cl00927
243231000784	Transcriptional accessory protein [Transcription]; Region: Tex; COG2183
243231000785	Tex-like protein N-terminal domain; Region: Tex_N; pfam09371
243231000786	Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination.  HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD includes...; Region: RuvC_resolvase; cl00243
243231000787	S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685
243231000788	RNA binding site [nucleotide binding]; other site
243231000789	Protein of unknown function, DUF393; Region: DUF393; cl01136
243231000790	NodN (nodulation factor N) contains a single hot dog fold similar to those of the peroxisomal Hydratase-Dehydrogenase-Epimerase (HDE) protein, and the fatty acid synthase beta subunit.  Rhizobium and related species form nodules on the roots of their...; Region: NodN; cd03450
243231000791	putative active site [active]
243231000792	putative catalytic site [active]
243231000793	B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293
243231000794	B12-binding domain/radical SAM domain protein, MJ_1487 family; Region: B12_SAM_MJ_1487; TIGR04013
243231000795	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
243231000796	FeS/SAM binding site; other site
243231000797	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
243231000798	active site
243231000799	Acyl transferase domain; Region: Acyl_transf_1; cl08282
243231000800	B12 binding domain_like associated with radical SAM domain. This domain shows similarity with B12 (adenosylcobamide) binding domains found in several enzymes, such as glutamate mutase, methionine synthase and methylmalonyl-CoA mutase, but it lacks the...; Region: radical_SAM_B12_BD; cd02068
243231000801	Elongator protein 3, MiaB family, Radical SAM; Region: Elp3; smart00729
243231000802	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
243231000803	FeS/SAM binding site; other site
243231000804	Phosphopantetheine attachment site; Region: PP-binding; cl09936
243231000805	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984
243231000806	putative acyl-acceptor binding pocket; other site
243231000807	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
243231000808	FeS/SAM binding site; other site
243231000809	Domain of unknown function (DUF4008); Region: DUF4008; cl14869
243231000810	DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179
243231000811	Ligand binding site; other site
243231000812	Putative Catalytic site; other site
243231000813	DXD motif; other site
243231000814	polysaccharide deacetylase family protein, PEP-CTERM locus subfamily; Region: pepcterm_polyde; TIGR03006
243231000815	Putative catalytic domain of uncharacterized prokaryotic polysaccharide deacetylases similar to bacterial PuuE allantoinases and Helicobacter pylori peptidoglycan deacetylase (HpPgdA); Region: CE4_PuuE_HpPgdA_like_2; cd10941
243231000816	putative active site [active]
243231000817	putative catalytic site [active]
243231000818	Fe-S oxidoreductase [Energy production and conversion]; Region: COG1032
243231000819	B12 binding domain_like associated with radical SAM domain. This domain shows similarity with B12 (adenosylcobamide) binding domains found in several enzymes, such as glutamate mutase, methionine synthase and methylmalonyl-CoA mutase, but it lacks the...; Region: radical_SAM_B12_BD; cd02068
243231000820	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
243231000821	FeS/SAM binding site; other site
243231000822	B12 binding domain_like associated with radical SAM domain. This domain shows similarity with B12 (adenosylcobamide) binding domains found in several enzymes, such as glutamate mutase, methionine synthase and methylmalonyl-CoA mutase, but it lacks the...; Region: radical_SAM_B12_BD; cd02068
243231000823	Elongator protein 3, MiaB family, Radical SAM; Region: Elp3; smart00729
243231000824	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
243231000825	FeS/SAM binding site; other site
243231000826	EamA-like transporter family; Region: EamA; cl01037
243231000827	Protein of unknown function (DUF2721); Region: DUF2721; pfam11026
243231000828	Domain of unknown function (DUF4372); Region: DUF4372; pfam14294
243231000829	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
243231000830	FOG: Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3385
243231000831	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
243231000832	PAS domain; Region: PAS_9; pfam13426
243231000833	putative active site [active]
243231000834	heme pocket [chemical binding]; other site
243231000835	GAF domain; Region: GAF_2; pfam13185
243231000836	GAF domain; Region: GAF; cl15785
243231000837	PAS domain S-box; Region: sensory_box; TIGR00229
243231000838	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
243231000839	putative active site [active]
243231000840	heme pocket [chemical binding]; other site
243231000841	Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal transduction mechanisms]; Region: COG4191
243231000842	PAS domain S-box; Region: sensory_box; TIGR00229
243231000843	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459
243231000844	Histidine kinase; Region: HisKA_3; pfam07730
243231000845	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
243231000846	ATP binding site [chemical binding]; other site
243231000847	Mg2+ binding site [ion binding]; other site
243231000848	G-X-G motif; other site
243231000849	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
243231000850	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
243231000851	active site
243231000852	phosphorylation site [posttranslational modification]
243231000853	intermolecular recognition site; other site
243231000854	dimerization interface [polypeptide binding]; other site
243231000855	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
243231000856	DNA binding residues [nucleotide binding]
243231000857	dimerization interface [polypeptide binding]; other site
243231000858	PAS fold; Region: PAS; pfam00989
243231000859	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
243231000860	putative active site [active]
243231000861	heme pocket [chemical binding]; other site
243231000862	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
243231000863	PAS fold; Region: PAS_3; pfam08447
243231000864	putative active site [active]
243231000865	heme pocket [chemical binding]; other site
243231000866	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
243231000867	dimer interface [polypeptide binding]; other site
243231000868	phosphorylation site [posttranslational modification]
243231000869	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
243231000870	ATP binding site [chemical binding]; other site
243231000871	Mg2+ binding site [ion binding]; other site
243231000872	G-X-G motif; other site
243231000873	Hemerythrin (Hr) is a non-heme diiron oxygen transport protein found in four marine invertebrate phyla including priapulida, brachiopoda, sipunculida, and annelida, as well as in protozoa. Myohemerythrin (Mhr), a hemerythrin homolog, is found in the...; Region: Hemerythrin; cl15774
243231000874	octamerization interface [polypeptide binding]; other site
243231000875	diferric-oxygen binding site [ion binding]; other site
243231000876	Antibiotic biosynthesis monooxygenase; Region: ABM; cl10022
243231000877	Flavin Reductases; Region: FlaRed; cl00801
243231000878	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
243231000879	Ligand Binding Site [chemical binding]; other site
243231000880	putative cation:proton antiport protein; Provisional; Region: PRK10669
243231000881	Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482
243231000882	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
243231000883	potential protein location (hypothetical protein) that overlaps protein (hypothetical protein)
243231000884	potential protein location (hypothetical protein) that overlaps protein (hypothetical protein)
243231000885	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
243231000886	bicyclomycin/multidrug efflux system; Provisional; Region: PRK11102
243231000887	putative substrate translocation pore; other site
243231000888	Membrane transport protein; Region: Mem_trans; cl09117
243231000889	Transcriptional regulator [Transcription]; Region: LysR; COG0583
243231000890	Helix-turn-helix domains; Region: HTH; cl00088
243231000891	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
243231000892	dimerization interface [polypeptide binding]; other site
243231000893	Transcriptional regulators [Transcription]; Region: PhnF; COG2188
243231000894	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
243231000895	DNA-binding site [nucleotide binding]; DNA binding site
243231000896	UTRA domain; Region: UTRA; cl01230
243231000897	Predicted permeases [General function prediction only]; Region: COG0730; cl00498
243231000898	Protein of unknown function (DUF1634); Region: DUF1634; cl01741
243231000899	glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331
243231000900	Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans).  The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714
243231000901	glutaminase active site [active]
243231000902	SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008
243231000903	dimer interface [polypeptide binding]; other site
243231000904	active site
243231000905	SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009
243231000906	dimer interface [polypeptide binding]; other site
243231000907	active site
243231000908	bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14355
243231000909	N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540
243231000910	Substrate binding site; other site
243231000911	Mg++ binding site; other site
243231000912	N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353
243231000913	active site
243231000914	substrate binding site [chemical binding]; other site
243231000915	CoA binding site [chemical binding]; other site
243231000916	B12 binding domain_like associated with radical SAM domain. This domain shows similarity with B12 (adenosylcobamide) binding domains found in several enzymes, such as glutamate mutase, methionine synthase and methylmalonyl-CoA mutase, but it lacks the...; Region: radical_SAM_B12_BD; cd02068
243231000917	Elongator protein 3, MiaB family, Radical SAM; Region: Elp3; smart00729
243231000918	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
243231000919	FeS/SAM binding site; other site
243231000920	Cytochrome c554 and c-prime; Region: Cytochrome_C554; pfam13435
243231000921	Heme-binding domain of the class III cytochrome C family and related proteins; Region: Cytochrom_C3; cl03439
243231000922	decaheme c-type cytochrome, DmsE family; Region: decahem_SO; TIGR03508
243231000923	type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843
243231000924	Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404
243231000925	Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404
243231000926	type I secretion system ATPase, LssB family; Region: type_I_sec_LssB; TIGR03375
243231000927	ABC transporter transmembrane region; Region: ABC_membrane; cl00549
243231000928	ABC-type bacteriocin exporters. Many non-lantibiotic bacteriocins of lactic acid bacteria are produced as precursors which have N-terminal leader peptides that share similarities in amino acid sequence and contain a conserved processing site of two...; Region: ABCC_bacteriocin_exporters; cd03245
243231000929	Walker A/P-loop; other site
243231000930	ATP binding site [chemical binding]; other site
243231000931	Q-loop/lid; other site
243231000932	ABC transporter signature motif; other site
243231000933	Walker B; other site
243231000934	D-loop; other site
243231000935	H-loop/switch region; other site
243231000936	type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844
243231000937	Cadherin tandem repeat domain; Region: Cadherin_repeat; cd11304
243231000938	Ca2+ binding site [ion binding]; other site
243231000939	Cadherin tandem repeat domain; Region: Cadherin_repeat; cd11304
243231000940	Ca2+ binding site [ion binding]; other site
243231000941	Cadherin tandem repeat domain; Region: Cadherin_repeat; cd11304
243231000942	Ca2+ binding site [ion binding]; other site
243231000943	Cadherin tandem repeat domain; Region: Cadherin_repeat; cd11304
243231000944	Ca2+ binding site [ion binding]; other site
243231000945	Cadherin tandem repeat domain; Region: Cadherin_repeat; cd11304
243231000946	Ca2+ binding site [ion binding]; other site
243231000947	Calx-beta domain; Region: Calx-beta; cl02522
243231000948	Calx-beta domain; Region: Calx-beta; cl02522
243231000949	Calx-beta domain; Region: Calx-beta; cl02522
243231000950	Calx-beta domain; Region: Calx-beta; cl02522
243231000951	Calx-beta domain; Region: Calx-beta; cl02522
243231000952	Calx-beta domain; Region: Calx-beta; cl02522
243231000953	Calx-beta domain; Region: Calx-beta; cl02522
243231000954	Calx-beta domain; Region: Calx-beta; cl02522
243231000955	Calx-beta domain; Region: Calx-beta; cl02522
243231000956	Calx-beta domain; Region: Calx-beta; cl02522
243231000957	Calx-beta domain; Region: Calx-beta; cl02522
243231000958	sodium/calcium exchanger 1; Region: caca; TIGR00845
243231000959	Calx-beta domain; Region: Calx-beta; cl02522
243231000960	Calx-beta domain; Region: Calx-beta; cl02522
243231000961	sodium/calcium exchanger 1; Region: caca; TIGR00845
243231000962	Calx-beta domain; Region: Calx-beta; cl02522
243231000963	sodium/calcium exchanger 1; Region: caca; TIGR00845
243231000964	Calx-beta domain; Region: Calx-beta; cl02522
243231000965	Calx-beta domain; Region: Calx-beta; cl02522
243231000966	sodium/calcium exchanger 1; Region: caca; TIGR00845
243231000967	Calx-beta domain; Region: Calx-beta; cl02522
243231000968	Calx-beta domain; Region: Calx-beta; cl02522
243231000969	Calx-beta domain; Region: Calx-beta; cl02522
243231000970	Calx-beta domain; Region: Calx-beta; cl02522
243231000971	Calx-beta domain; Region: Calx-beta; cl02522
243231000972	Calx-beta domain; Region: Calx-beta; cl02522
243231000973	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
243231000974	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
243231000975	active site
243231000976	phosphorylation site [posttranslational modification]
243231000977	intermolecular recognition site; other site
243231000978	dimerization interface [polypeptide binding]; other site
243231000979	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
243231000980	Walker A motif; other site
243231000981	ATP binding site [chemical binding]; other site
243231000982	Walker B motif; other site
243231000983	Helix-turn-helix domains; Region: HTH; cl00088
243231000984	GAF domain; Region: GAF_2; pfam13185
243231000985	GAF domain; Region: GAF; cl15785
243231000986	GAF domain; Region: GAF; cl15785
243231000987	Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852
243231000988	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
243231000989	dimer interface [polypeptide binding]; other site
243231000990	phosphorylation site [posttranslational modification]
243231000991	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
243231000992	ATP binding site [chemical binding]; other site
243231000993	Mg2+ binding site [ion binding]; other site
243231000994	G-X-G motif; other site
243231000995	Prokaryotic dksA/traR C4-type zinc finger; Region: zf-dskA_traR; cl00755
243231000996	DNA repair protein RadA; Provisional; Region: PRK11823
243231000997	Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121
243231000998	Walker A motif/ATP binding site; other site
243231000999	ATP binding site [chemical binding]; other site
243231001000	Walker B motif; other site
243231001001	Subunit ChlI of Mg-chelatase; Region: ChlI; cl12214
243231001002	FOG: HEAT repeat [Energy production and conversion]; Region: COG1413
243231001003	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
243231001004	Zn2+ binding site [ion binding]; other site
243231001005	Mg2+ binding site [ion binding]; other site
243231001006	HEAT repeats; Region: HEAT_2; pfam13646
243231001007	3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352
243231001008	Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830
243231001009	dimer interface [polypeptide binding]; other site
243231001010	active site
243231001011	CoA binding pocket [chemical binding]; other site
243231001012	Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352
243231001013	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911
243231001014	chemotaxis-specific methylesterase; Provisional; Region: PRK00742
243231001015	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
243231001016	active site
243231001017	phosphorylation site [posttranslational modification]
243231001018	intermolecular recognition site; other site
243231001019	dimerization interface [polypeptide binding]; other site
243231001020	CheB methylesterase; Region: CheB_methylest; pfam01339
243231001021	HDOD domain; Region: HDOD; pfam08668
243231001022	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076
243231001023	CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705
243231001024	Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352
243231001025	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911
243231001026	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088
243231001027	putative binding surface; other site
243231001028	active site
243231001029	Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895
243231001030	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
243231001031	ATP binding site [chemical binding]; other site
243231001032	Mg2+ binding site [ion binding]; other site
243231001033	G-X-G motif; other site
243231001034	CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731
243231001035	CheW, a small regulator protein, unique to the chemotaxis signalling in prokaryotes and archea. CheW interacts with the histidine kinase CheA, most likely with the related regulatory domain of CheA. CheW is proposed to form signalling arrays together...; Region: CheW; cd00732
243231001036	putative CheA interaction surface; other site
243231001037	Response regulator receiver domain; Region: Response_reg; pfam00072
243231001038	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
243231001039	active site
243231001040	phosphorylation site [posttranslational modification]
243231001041	intermolecular recognition site; other site
243231001042	dimerization interface [polypeptide binding]; other site
243231001043	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
243231001044	Walker A motif; other site
243231001045	ATP binding site [chemical binding]; other site
243231001046	Walker B motif; other site
243231001047	arginine finger; other site
243231001048	Domain of unknown function (DUF4372); Region: DUF4372; pfam14294
243231001049	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
243231001050	FOG: Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3385
243231001051	Transcriptional regulator containing PAS, AAA-type ATPase, and DNA-binding domains [Transcription / Signal transduction mechanisms]; Region: RocR; COG3829
243231001052	Helix-turn-helix domains; Region: HTH; cl00088
243231001053	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic 'goose-type' lysozymes (GEWL).  LTs catalyze...; Region: LT_GEWL; cd00254
243231001054	N-acetyl-D-glucosamine binding site [chemical binding]; other site
243231001055	catalytic residue [active]
243231001056	Protein of unknown function (DUF3365); Region: DUF3365; pfam11845
243231001057	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
243231001058	dimerization interface [polypeptide binding]; other site
243231001059	PAS domain S-box; Region: sensory_box; TIGR00229
243231001060	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459
243231001061	aminopeptidase N; Provisional; Region: pepN; PRK14015
243231001062	Peptidase M1 family containing Aminopeptidase N; Region: M1_APN_1; cd09600
243231001063	active site
243231001064	Zn binding site [ion binding]; other site
243231001065	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
243231001066	G4 box; other site
243231001067	G5 box; other site
243231001068	Acylphosphatase; Region: Acylphosphatase; cl00551
243231001069	Hydrogenase maturation factor [Posttranslational modification, protein turnover, chaperones]; Region: HypF; COG0068
243231001070	HypF finger; Region: zf-HYPF; pfam07503
243231001071	HypF finger; Region: zf-HYPF; pfam07503
243231001072	Telomere recombination; Region: Sua5_yciO_yrdC; cl00305
243231001073	HupF/HypC family; Region: HupF_HypC; cl00394
243231001074	Hydrogenase formation hypA family; Region: HypD; cl12072
243231001075	Hydrogenase maturation factor [Posttranslational modification, protein turnover, chaperones]; Region: HypD; COG0409
243231001076	hydrogenase expression/formation protein HypE; Region: hypE; TIGR02124
243231001077	HypE (Hydrogenase expression/formation protein). HypE is involved in Ni-Fe hydrogenase biosynthesis.  HypE dehydrates its own carbamoyl moiety in an ATP-dependent process to yield the enzyme thiocyanate. The N-terminal domain of HypE is related to the...; Region: HypE; cd02197
243231001078	dimerization interface [polypeptide binding]; other site
243231001079	ATP binding site [chemical binding]; other site
243231001080	ExoU and VipD-like proteins; homologus to patatin, cPLA2, and iPLA2; Region: Pat_ExoU_VipD_like; cd07207
243231001081	active site
243231001082	nucleophile elbow; other site
243231001083	PilZ domain; Region: PilZ; cl01260
243231001084	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
243231001085	HSP70 interaction site [polypeptide binding]; other site
243231001086	Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157
243231001087	Roadblock/LC7 domain; Region: Robl_LC7; cl00886
243231001088	Domain of unknown function (DUF4388); Region: DUF4388; pfam14332
243231001089	Roadblock/LC7 domain; Region: Robl_LC7; cl00886
243231001090	Peptidase family M48; Region: Peptidase_M48; cl12018
243231001091	AsmA-like C-terminal region; Region: AsmA_2; cl15864
243231001092	type II secretion system protein L; Region: typeII_sec_gspL; TIGR01709
243231001093	GspL periplasmic domain; Region: GspL_C; cl14909
243231001094	Type II secretion system (T2SS), protein K; Region: T2SK; pfam03934
243231001095	Type II secretion system (T2SS), protein J; Region: T2SJ; pfam11612
243231001096	type II secretion system protein G; Region: typeII_sec_gspG; TIGR01710
243231001097	Type II secretion system (T2SS), protein G; Region: T2SG; pfam08334
243231001098	type II secretion system protein F; Region: GspF; TIGR02120
243231001099	Type II secretion system (T2SS), protein F; Region: T2SF; cl00906
243231001100	Type II secretion system (T2SS), protein F; Region: T2SF; cl00906
243231001101	Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157
243231001102	type II secretion system protein E; Region: type_II_gspE; TIGR02533
243231001103	PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129
243231001104	Walker A motif; other site
243231001105	ATP binding site [chemical binding]; other site
243231001106	Walker B motif; other site
243231001107	type II secretion system protein D; Region: type_II_gspD; TIGR02517
243231001108	Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958
243231001109	Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958
243231001110	Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958
243231001111	Bacterial type II and III secretion system protein; Region: Secretin; pfam00263
243231001112	Type IV pilus biogenesis; Region: Pilus_PilP; cl11837
243231001113	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
243231001114	periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037
243231001115	Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149
243231001116	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
243231001117	protein binding site [polypeptide binding]; other site
243231001118	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
243231001119	protein binding site [polypeptide binding]; other site
243231001120	multifunctional aminopeptidase A; Provisional; Region: PRK00913
243231001121	Cytosol aminopeptidase family, N-terminal and catalytic domains.  Family M17 contains zinc- and manganese-dependent exopeptidases ( EC  3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433
243231001122	interface (dimer of trimers) [polypeptide binding]; other site
243231001123	Substrate-binding/catalytic site; other site
243231001124	Zn-binding sites [ion binding]; other site
243231001125	ATP synthase subunit C; Region: ATP-synt_C; cl00466
243231001126	ATP synthase A chain; Region: ATP-synt_A; cl00413
243231001127	Putative F0F1-ATPase subunit (ATPase_gene1); Region: ATPase_gene1; cl09754
243231001128	glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062
243231001129	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
243231001130	inhibitor-cofactor binding pocket; inhibition site
243231001131	pyridoxal 5'-phosphate binding site [chemical binding]; other site
243231001132	catalytic residue [active]
243231001133	NADH-ubiquinone/plastoquinone oxidoreductase, chain 3; Region: Oxidored_q4; cl00535
243231001134	NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; cl15792
243231001135	Respiratory-chain NADH dehydrogenase, 30 Kd subunit; Region: Complex1_30kDa; cl16917
243231001136	Nickel-dependent hydrogenase; Region: NiFeSe_Hases; cl00417
243231001137	Respiratory-chain NADH dehydrogenase, 49 Kd subunit; Region: Complex1_49kDa; pfam00346
243231001138	Respiratory-chain NADH dehydrogenase 24 Kd subunit; Region: Complex1_24kDa; pfam01257
243231001139	TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064
243231001140	putative dimer interface [polypeptide binding]; other site
243231001141	[2Fe-2S] cluster binding site [ion binding]; other site
243231001142	Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980
243231001143	dimer interface [polypeptide binding]; other site
243231001144	[2Fe-2S] cluster binding site [ion binding]; other site
243231001145	NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit [Energy production and conversion]; Region: NuoF; COG1894
243231001146	SLBB domain; Region: SLBB; pfam10531
243231001147	NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; cl11211
243231001148	Uncharacterized Fe-S center protein [General function prediction only]; Region: COG2768
243231001149	4Fe-4S binding domain; Region: Fer4; cl02805
243231001150	Uncharacterized anaerobic dehydrogenase [General function prediction only]; Region: COG3383
243231001151	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
243231001152	catalytic loop [active]
243231001153	iron binding site [ion binding]; other site
243231001154	NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; cl11210
243231001155	4Fe-4S binding domain; Region: Fer4; cl02805
243231001156	MopB_NDH-1_NuoG2-N7: The second domain of the NuoG subunit (with a [4Fe-4S] cluster, N7) of the NADH-quinone oxidoreductase/NADH dehydrogenase-1 (NDH-1) found in various bacteria. The NDH-1 is the first energy-transducting complex in the respiratory...; Region: MopB_NDH-1_NuoG2-N7; cd02771
243231001157	[4Fe-4S] binding site [ion binding]; other site
243231001158	Molybdopterin-Binding, C-terminal (MopB_CT) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum-...; Region: MopB_CT; cl09929
243231001159	molybdopterin cofactor binding site; other site
243231001160	NADH dehydrogenase; Region: NADHdh; cl00469
243231001161	NADH dehydrogenase subunit I; Provisional; Region: PRK05888
243231001162	4Fe-4S binding domain; Region: Fer4; cl02805
243231001163	NADH:ubiquinone oxidoreductase subunit J; Provisional; Region: PRK06638
243231001164	NADH dehydrogenase subunit J; Provisional; Region: PRK06433; cl14634
243231001165	NADH-ubiquinone/plastoquinone oxidoreductase chain 4L; Region: Oxidored_q2; cl00492
243231001166	NADH:ubiquinone oxidoreductase subunit L; Reviewed; Region: PRK06590
243231001167	NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662
243231001168	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; cl14187
243231001169	NADH-Ubiquinone oxidoreductase (complex I) subunit C-terminus; Region: Oxidored_q1_C; pfam01010
243231001170	NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846
243231001171	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; cl14187
243231001172	NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777
243231001173	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; cl14187
243231001174	Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014
243231001175	dimer interface [polypeptide binding]; other site
243231001176	catalytic triad [active]
243231001177	peroxidatic and resolving cysteines [active]
243231001178	SNARE associated Golgi protein; Region: SNARE_assoc; cl00429
243231001179	Putative metallopeptidase domain; Region: DUF2201_N; pfam13203
243231001180	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057
243231001181	Cytochrome c552; Region: Cytochrom_C552; pfam02335
243231001182	ferredoxin; Validated; Region: PRK07118
243231001183	PAS domain; Region: PAS_10; pfam13596
243231001184	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
243231001185	putative active site [active]
243231001186	heme pocket [chemical binding]; other site
243231001187	psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974
243231001188	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
243231001189	Walker A motif; other site
243231001190	ATP binding site [chemical binding]; other site
243231001191	Walker B motif; other site
243231001192	arginine finger; other site
243231001193	Helix-turn-helix domains; Region: HTH; cl00088
243231001194	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl01155
243231001195	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
243231001196	ligand binding site [chemical binding]; other site
243231001197	peptidyl-prolyl cis-trans isomerase, EpsD family; Region: cis_trans_EpsD; TIGR02925
243231001198	peptidylprolyl isomerase; Provisional; Region: prsA; PRK00059
243231001199	PPIC-type PPIASE domain; Region: Rotamase; cl08278
243231001200	Mpr1p, Pad1p N-terminal (MPN) domains; Region: MPN; cl13996
243231001201	ATP-dependent DNA helicase DinG; Provisional; Region: dinG; PRK11747
243231001202	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
243231001203	Heme-binding domain of the class III cytochrome C family and related proteins; Region: Cytochrom_C3; cd08168
243231001204	heme-binding residues [chemical binding]; other site
243231001205	Heme-binding domain of the class III cytochrome C family and related proteins; Region: Cytochrom_C3; cd08168
243231001206	heme-binding residues [chemical binding]; other site
243231001207	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
243231001208	non-specific DNA binding site [nucleotide binding]; other site
243231001209	salt bridge; other site
243231001210	sequence-specific DNA binding site [nucleotide binding]; other site
243231001211	Predicted Fe-S oxidoreductase [General function prediction only]; Region: COG1242
243231001212	Surface antigen; Region: Bac_surface_Ag; cl03097
243231001213	Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257; cl15822
243231001214	Flagellar hook-length control protein FliK; Region: Flg_hook; cl15269
243231001215	This family is most closely related to the oligosaccharide phosphorylase domain family and other unidentified sequences. Oligosaccharide phosphorylase catalyzes the breakdown of oligosaccharides into glucose-1-phosphate units. They are important...; Region: GT1_Glycogen_Phosphorylase_like; cd04299
243231001216	putative homodimer interface [polypeptide binding]; other site
243231001217	putative active site pocket [active]
243231001218	alpha-glucan phosphorylases; Region: more_P_ylases; TIGR02094
243231001219	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
243231001220	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
243231001221	active site
243231001222	phosphorylation site [posttranslational modification]
243231001223	intermolecular recognition site; other site
243231001224	dimerization interface [polypeptide binding]; other site
243231001225	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
243231001226	Walker A motif; other site
243231001227	ATP binding site [chemical binding]; other site
243231001228	Walker B motif; other site
243231001229	arginine finger; other site
243231001230	Helix-turn-helix domains; Region: HTH; cl00088
243231001231	Signal transduction histidine kinase regulating citrate/malate metabolism [Signal transduction mechanisms]; Region: CitA; COG3290
243231001232	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
243231001233	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
243231001234	dimerization interface [polypeptide binding]; other site
243231001235	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
243231001236	dimer interface [polypeptide binding]; other site
243231001237	phosphorylation site [posttranslational modification]
243231001238	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
243231001239	ATP binding site [chemical binding]; other site
243231001240	Mg2+ binding site [ion binding]; other site
243231001241	G-X-G motif; other site
243231001242	Hydrogenase expression/synthesis hypA family; Region: HypA; pfam01155
243231001243	hydrogenase nickel incorporation protein; Provisional; Region: hypA; cl00418
243231001244	glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389
243231001245	Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669
243231001246	Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848
243231001247	lipoyl attachment site [posttranslational modification]; other site
243231001248	glycine dehydrogenase subunit 1; Validated; Region: PRK00451
243231001249	Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613
243231001250	tetramer interface [polypeptide binding]; other site
243231001251	pyridoxal 5'-phosphate binding site [chemical binding]; other site
243231001252	catalytic residue [active]
243231001253	Glycine cleavage system protein P (pyridoxal-binding), C-terminal domain [Amino acid transport and metabolism]; Region: GcvP; COG1003
243231001254	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
243231001255	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
243231001256	catalytic residue [active]
243231001257	Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095
243231001258	Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057
243231001259	lipoyl synthase; Provisional; Region: PRK05481
243231001260	outer membrane assembly lipoprotein YfiO; Region: OM_YfiO; TIGR03302
243231001261	OsmC-like protein; Region: OsmC; cl00767
243231001262	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; cl11587
243231001263	FKBP-type peptidyl-prolyl cis-trans isomerases 2 [Posttranslational modification, protein turnover, chaperones]; Region: SlpA; COG1047
243231001264	Uncharacterized family of ferritin-like proteins found in archaea and bacteria; Region: Ferritin_like_AB; cd01045
243231001265	diiron binding motif [ion binding]; other site
243231001266	Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702
243231001267	NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, subunit 9, 39 kDa, (NDUFA9) -like, atypical (a) SDRs; Region: NDUFA9_like_SDR_a; cd05271
243231001268	putative NAD(P) binding site [chemical binding]; other site
243231001269	active site
243231001270	hypothetical protein; Reviewed; Region: PRK00024
243231001271	Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071
243231001272	MPN+ (JAMM) motif; other site
243231001273	Zinc-binding site [ion binding]; other site
243231001274	Bacitracin resistance protein BacA; Region: BacA; cl00858
243231001275	Phosphate transport regulator (distant homolog of PhoU) [Inorganic ion transport and metabolism]; Region: COG1392
243231001276	Phosphate transporter family; Region: PHO4; cl00396
243231001277	Uncharacterized protein conserved in bacteria (DUF2062); Region: DUF2062; cl01261
243231001278	Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538
243231001279	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
243231001280	Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404
243231001281	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
243231001282	Protein export membrane protein; Region: SecD_SecF; cl14618
243231001283	Putative redox-active protein (C_GCAxxG_C_C); Region: C_GCAxxG_C_C; cl09920
243231001284	Protein of unknown function (DUF2892); Region: DUF2892; pfam11127
243231001285	Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446
243231001286	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
243231001287	active site residue [active]
243231001288	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
243231001289	dimerization interface [polypeptide binding]; other site
243231001290	putative DNA binding site [nucleotide binding]; other site
243231001291	putative Zn2+ binding site [ion binding]; other site
243231001292	Cache domain; Region: Cache_2; cl07034
243231001293	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
243231001294	dimerization interface [polypeptide binding]; other site
243231001295	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
243231001296	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
243231001297	dimer interface [polypeptide binding]; other site
243231001298	putative CheW interface [polypeptide binding]; other site
243231001299	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
243231001300	dimerization interface [polypeptide binding]; other site
243231001301	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
243231001302	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
243231001303	dimer interface [polypeptide binding]; other site
243231001304	putative CheW interface [polypeptide binding]; other site
243231001305	Hemerythrin (Hr) is a non-heme diiron oxygen transport protein found in four marine invertebrate phyla including priapulida, brachiopoda, sipunculida, and annelida, as well as in protozoa. Myohemerythrin (Mhr), a hemerythrin homolog, is found in the...; Region: Hemerythrin; cl15774
243231001306	octamerization interface [polypeptide binding]; other site
243231001307	diferric-oxygen binding site [ion binding]; other site
243231001308	Response regulator receiver domain; Region: Response_reg; pfam00072
243231001309	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
243231001310	active site
243231001311	phosphorylation site [posttranslational modification]
243231001312	intermolecular recognition site; other site
243231001313	dimerization interface [polypeptide binding]; other site
243231001314	Predicted inhibitor of MCP methylation, homolog of CheC [Cell motility and secretion]; Region: COG1406
243231001315	Chemotaxis phosphatase CheX; Region: CheX; cl15816
243231001316	Response regulator receiver domain; Region: Response_reg; pfam00072
243231001317	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
243231001318	active site
243231001319	phosphorylation site [posttranslational modification]
243231001320	intermolecular recognition site; other site
243231001321	dimerization interface [polypeptide binding]; other site
243231001322	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1729
243231001323	putative PEP-CTERM system TPR-repeat lipoprotein; Region: PEP_TPR_lipo; TIGR02917
243231001324	Flagella basal body rod protein; Region: Flg_bb_rod; cl16922
243231001325	flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK05680
243231001326	flagellar basal body rod protein FlgC; Reviewed; Region: flgC; PRK05681
243231001327	Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; cl15855
243231001328	Flagellar hook-basal body complex protein FliE; Region: FliE; cl09139
243231001329	flagellar MS-ring protein; Reviewed; Region: fliF; PRK06007
243231001330	Secretory protein of YscJ/FliF family; Region: YscJ_FliF; cl01907
243231001331	Flagellar M-ring protein C-terminal; Region: YscJ_FliF_C; pfam08345
243231001332	flagellar motor switch protein G; Validated; Region: fliG; PRK05686
243231001333	FliG C-terminal domain; Region: FliG_C; pfam01706
243231001334	Flagellar biosynthesis/type III secretory pathway protein [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FliH; COG1317
243231001335	Flagellar assembly protein FliH; Region: FliH; pfam02108
243231001336	flagellar protein export ATPase FliI; Region: FliI_clade1; TIGR03496
243231001337	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; cl15275
243231001338	Flagellum-specific ATPase/type III secretory pathway virulence-related protein. This group of ATPases are responsible for the export of flagellum and virulence-related proteins. The bacterial flagellar motor is similar to the F0F1-ATPase, in that they...; Region: ATPase_flagellum-secretory_path_III; cd01136
243231001339	Walker A motif/ATP binding site; other site
243231001340	Walker B motif; other site
243231001341	flagellar export protein FliJ; Region: flagell_FliJ; TIGR02473
243231001342	MgtE intracellular N domain; Region: MgtE_N; cl15244
243231001343	Flagellar hook-length control protein FliK; Region: Flg_hook; cl15269
243231001344	Flagellar hook capping protein [Cell motility and secretion]; Region: FlgD; COG1843
243231001345	Flagellar hook capping protein - N-terminal region; Region: FlgD; pfam03963
243231001346	FlgD Ig-like domain; Region: FlgD_ig; cl15790
243231001347	Protein of unknown function (DUF3766); Region: DUF3766; cl11797
243231001348	flagellar hook protein FlgE; Validated; Region: flgE; PRK05682
243231001349	Flagella basal body rod protein; Region: Flg_bb_rod; cl16922
243231001350	Flagellar basal body protein FlaE; Region: FlaE; pfam07559
243231001351	Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; cl15855
243231001352	Flagellar basal body-associated protein FliL; Region: FliL; cl00681
243231001353	flagellar motor switch protein FliM; Validated; Region: fliM; PRK06666
243231001354	Surface presentation of antigens (SPOA); Region: SpoA; cl00819
243231001355	Surface presentation of antigens (SPOA); Region: SpoA; cl00819
243231001356	FliP family; Region: FliP; cl00593
243231001357	Bacterial export proteins, family 3; Region: Bac_export_3; cl00867
243231001358	Bacterial export proteins, family 1; Region: Bac_export_1; cl00734
243231001359	flagellar biosynthesis protein FlhB; Reviewed; Region: flhB; PRK05702
243231001360	Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257; cl15822
243231001361	Bacterial SH3 domain; Region: SH3_3; cl02551
243231001362	Type VI secretion lipoprotein; Region: T6SS-SciN; cl01405
243231001363	Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and    vesicular transport]; Region: COG3522; cl01406
243231001364	Bacterial protein of unknown function (DUF876); Region: DUF876; pfam05936
243231001365	Gene 25-like lysozyme; Region: GPW_gp25; cl01403
243231001366	Bacterial protein of unknown function (DUF879); Region: DUF879; cl15462
243231001367	Type VI protein secretion system component VasA [Intracellular trafficking, secretion, and    vesicular transport]; Region: COG3519
243231001368	Protein of unknown function (DUF1305); Region: DUF1305; cl01404
243231001369	type VI secretion ATPase, ClpV1 family; Region: VI_ClpV1; TIGR03345
243231001370	Clp amino terminal domain; Region: Clp_N; pfam02861
243231001371	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
243231001372	Walker A motif; other site
243231001373	ATP binding site [chemical binding]; other site
243231001374	Walker B motif; other site
243231001375	arginine finger; other site
243231001376	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
243231001377	Walker A motif; other site
243231001378	ATP binding site [chemical binding]; other site
243231001379	Walker B motif; other site
243231001380	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; cl11083
243231001381	Predicted tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase, contains the PP-loop ATPase domain [Translation, ribosomal structure and biogenesis]; Region: TrmU; COG0482
243231001382	ThiI is required for thiazole synthesis in the thiamine biosynthesis pathway. It belongs to the Adenosine Nucleotide Hydrolysis suoerfamily and predicted to bind to Adenosine nucleotide; Region: ThiI; cd01712
243231001383	Ligand Binding Site [chemical binding]; other site
243231001384	Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157
243231001385	Type II secretory pathway, ATPase PulE/Tfp pilus assembly pathway, ATPase PilB [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulE; COG2804
243231001386	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
243231001387	Walker A motif; other site
243231001388	ATP binding site [chemical binding]; other site
243231001389	Walker B motif; other site
243231001390	pilus retraction protein PilT; Region: pilT_fam; TIGR01420
243231001391	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
243231001392	Walker A motif; other site
243231001393	ATP binding site [chemical binding]; other site
243231001394	Walker B motif; other site
243231001395	3-octaprenyl-4-hydroxybenzoate carboxy-lyase; Region: UbiD; cl00311
243231001396	UbiA prenyltransferase family; Region: UbiA; cl00337
243231001397	Flavoprotein; Region: Flavoprotein; cl08021
243231001398	aromatic acid decarboxylase; Validated; Region: PRK05920
243231001399	putative menaquinone biosynthesis protein, SCO4494 family; Region: mena_SCO4494; TIGR03700
243231001400	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
243231001401	FeS/SAM binding site; other site
243231001402	menaquinone biosynthesis protein, SCO4550 family; Region: mena_SCO4550; TIGR03699
243231001403	Ribonuclease D [Translation, ribosomal structure and biogenesis]; Region: Rnd; COG0349
243231001404	DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142
243231001405	catalytic site [active]
243231001406	putative active site [active]
243231001407	putative substrate binding site [chemical binding]; other site
243231001408	HRDC domain; Region: HRDC; cl02578
243231001409	HRDC domain; Region: HRDC; cl02578
243231001410	potential protein location (hypothetical protein) that overlaps protein (hypothetical protein)
243231001411	potential protein location (hypothetical protein) that overlaps protein (hypothetical protein)
243231001412	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1385; cl00611
243231001413	RNA methyltransferase; Region: Methyltrans_RNA; pfam04452
243231001414	ribosomal protein L11 methyltransferase; Reviewed; Region: prmA; PRK00517
243231001415	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
243231001416	S-adenosylmethionine binding site [chemical binding]; other site
243231001417	M20 Peptidase Aminoacylase 1-like protein 2-like, amidohydrolase subfamily; Region: M20_ACY1L2_like; cd05672
243231001418	amidohydrolase; Region: amidohydrolases; TIGR01891
243231001419	metal binding site [ion binding]; metal-binding site
243231001420	Kinase/pyrophosphorylase; Region: Kinase-PPPase; cl00780
243231001421	heavy metal response regulator; Region: cztR_silR_copR; TIGR01387
243231001422	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
243231001423	active site
243231001424	phosphorylation site [posttranslational modification]
243231001425	intermolecular recognition site; other site
243231001426	dimerization interface [polypeptide binding]; other site
243231001427	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
243231001428	DNA binding site [nucleotide binding]
243231001429	heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386
243231001430	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
243231001431	dimerization interface [polypeptide binding]; other site
243231001432	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
243231001433	dimer interface [polypeptide binding]; other site
243231001434	phosphorylation site [posttranslational modification]
243231001435	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
243231001436	ATP binding site [chemical binding]; other site
243231001437	Mg2+ binding site [ion binding]; other site
243231001438	G-X-G motif; other site
243231001439	Phosphorylase superfamily; Region: PNP_UDP_1; cl00303
243231001440	NMT1-like family; Region: NMT1_2; cl15260
243231001441	Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; cl04011
243231001442	hopanoid biosynthesis associated RND transporter like protein HpnN; Region: HpnN; TIGR03480
243231001443	Outer membrane lipoprotein LolB; Region: LolB; pfam03550
243231001444	lipoprotein chaperone; Reviewed; Region: lolA; PRK00031
243231001445	The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509
243231001446	active site 2 [active]
243231001447	active site 1 [active]
243231001448	Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938
243231001449	active site
243231001450	beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150
243231001451	Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834
243231001452	dimer interface [polypeptide binding]; other site
243231001453	active site
243231001454	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
243231001455	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557
243231001456	NAD(P) binding site [chemical binding]; other site
243231001457	active site
243231001458	Peptidase family M48; Region: Peptidase_M48; cl12018
243231001459	Bacterial protein of unknown function (DUF898); Region: DUF898; cl01738
243231001460	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
243231001461	RNA binding surface [nucleotide binding]; other site
243231001462	elongation factor P; Provisional; Region: PRK14578
243231001463	Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207
243231001464	S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470
243231001465	RNA binding site [nucleotide binding]; other site
243231001466	S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794
243231001467	RNA binding site [nucleotide binding]; other site
243231001468	Cytochrome c peroxidase [Inorganic ion transport and metabolism]; Region: MauG; COG1858
243231001469	Protein of unknown function (DUF3187); Region: DUF3187; pfam11383
243231001470	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
243231001471	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
243231001472	active site
243231001473	phosphorylation site [posttranslational modification]
243231001474	intermolecular recognition site; other site
243231001475	dimerization interface [polypeptide binding]; other site
243231001476	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
243231001477	Walker A motif; other site
243231001478	ATP binding site [chemical binding]; other site
243231001479	Walker B motif; other site
243231001480	arginine finger; other site
243231001481	Helix-turn-helix domains; Region: HTH; cl00088
243231001482	sensor protein ZraS; Provisional; Region: PRK10364
243231001483	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
243231001484	dimer interface [polypeptide binding]; other site
243231001485	phosphorylation site [posttranslational modification]
243231001486	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
243231001487	ATP binding site [chemical binding]; other site
243231001488	Mg2+ binding site [ion binding]; other site
243231001489	G-X-G motif; other site
243231001490	Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_3; cd07820
243231001491	putative hydrophobic ligand binding site [chemical binding]; other site
243231001492	Predicted transcriptional regulator [Transcription]; Region: COG2378
243231001493	Helix-turn-helix domains; Region: HTH; cl00088
243231001494	WYL domain; Region: WYL; cl14852
243231001495	PAS domain S-box; Region: sensory_box; TIGR00229
243231001496	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
243231001497	putative active site [active]
243231001498	heme pocket [chemical binding]; other site
243231001499	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
243231001500	PAS domain; Region: PAS_9; pfam13426
243231001501	putative active site [active]
243231001502	heme pocket [chemical binding]; other site
243231001503	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
243231001504	metal binding site [ion binding]; metal-binding site
243231001505	active site
243231001506	I-site; other site
243231001507	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
243231001508	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
243231001509	putative active site [active]
243231001510	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
243231001511	heme pocket [chemical binding]; other site
243231001512	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
243231001513	dimer interface [polypeptide binding]; other site
243231001514	phosphorylation site [posttranslational modification]
243231001515	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
243231001516	ATP binding site [chemical binding]; other site
243231001517	Mg2+ binding site [ion binding]; other site
243231001518	G-X-G motif; other site
243231001519	Uncharacterized conserved protein [Function unknown]; Region: COG1565
243231001520	Putative S-adenosyl-L-methionine-dependent methyltransferase; Region: Methyltransf_28; pfam02636
243231001521	Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419
243231001522	Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391
243231001523	Uncharacterized family of ferritin-like proteins found in archaea and bacteria; Region: Ferritin_like_AB; cd01045
243231001524	diiron binding motif [ion binding]; other site
243231001525	aspartate ammonia-lyase; Provisional; Region: aspA; PRK12273
243231001526	Aspartase; Region: Aspartase; cd01357
243231001527	active sites [active]
243231001528	tetramer interface [polypeptide binding]; other site
243231001529	NifU-like domain; Region: NifU; cl00484
243231001530	Phosphatidylserine/phosphatidylglycerophosphate/car diolipin synthases and related enzymes [Lipid metabolism]; Region: Cls; COG1502
243231001531	Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110
243231001532	putative active site [active]
243231001533	catalytic site [active]
243231001534	Catalytic domain, repeat 2, of Escherichia coli cardiolipin synthase ybhO and similar proteins; Region: PLDc_ybhO_like_2; cd09159
243231001535	putative active site [active]
243231001536	catalytic site [active]
243231001537	ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995
243231001538	Ligand Binding Site [chemical binding]; other site
243231001539	Type I GTP cyclohydrolase folE2; Region: GCHY-1; cl00642
243231001540	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
243231001541	threonine dehydratase; Provisional; Region: PRK08198
243231001542	Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562
243231001543	tetramer interface [polypeptide binding]; other site
243231001544	pyridoxal 5'-phosphate binding site [chemical binding]; other site
243231001545	catalytic residue [active]
243231001546	C-terminal ACT domain of biodegradative (catabolic) threonine dehydratase II (ThrD-II) and other related ACT domains; Region: ACT_ThrD-II-like; cd04886
243231001547	Cation efflux family; Region: Cation_efflux; cl00316
243231001548	thioredoxin reductase; Provisional; Region: PRK10262
243231001549	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
243231001550	Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606
243231001551	Subunit ChlI of Mg-chelatase; Region: ChlI; cl12214
243231001552	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
243231001553	Walker A motif; other site
243231001554	ATP binding site [chemical binding]; other site
243231001555	Walker B motif; other site
243231001556	arginine finger; other site
243231001557	Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335
243231001558	Acetyl-CoA hydrolase/transferase N-terminal domain; Region: AcetylCoA_hydro; pfam02550
243231001559	succinate CoA transferases; Region: YgfH_subfam; TIGR03458
243231001560	SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339
243231001561	ATP-dependent RNA helicase SrmB; Provisional; Region: PRK11192
243231001562	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
243231001563	ATP binding site [chemical binding]; other site
243231001564	putative Mg++ binding site [ion binding]; other site
243231001565	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
243231001566	nucleotide binding region [chemical binding]; other site
243231001567	ATP-binding site [chemical binding]; other site
243231001568	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
243231001569	tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224
243231001570	active site
243231001571	DNA binding site [nucleotide binding]
243231001572	Int/Topo IB signature motif; other site
243231001573	NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252
243231001574	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
243231001575	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
243231001576	Uncharacterized conserved protein [Function unknown]; Region: COG2006
243231001577	Domain of unknown function (DUF362); Region: DUF362; pfam04015
243231001578	Dissimilatory sulfite reductase (desulfoviridin), alpha and beta subunits [Energy production and conversion]; Region: DsrA; COG2221
243231001579	4Fe-4S binding domain; Region: Fer4; cl02805
243231001580	macrolide transporter subunit MacA; Provisional; Region: PRK11578
243231001581	Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404
243231001582	Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404
243231001583	Peptidase family M23; Region: Peptidase_M23; pfam01551
243231001584	GTP-binding protein TypA/BipA; Region: TypA_BipA; TIGR01394
243231001585	Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891
243231001586	G1 box; other site
243231001587	putative GEF interaction site [polypeptide binding]; other site
243231001588	GTP/Mg2+ binding site [chemical binding]; other site
243231001589	Switch I region; other site
243231001590	G2 box; other site
243231001591	G3 box; other site
243231001592	Switch II region; other site
243231001593	G4 box; other site
243231001594	G5 box; other site
243231001595	BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu.  BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691
243231001596	BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants.  BipA is a highly...; Region: BipA_TypA_C; cd03710
243231001597	outer membrane assembly lipoprotein YfiO; Region: OM_YfiO; TIGR03302
243231001598	Tetratricopeptide repeat; Region: TPR_6; pfam13174
243231001599	Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109
243231001600	CrcB-like protein; Region: CRCB; cl09114
243231001601	Uncharacterized ACR, COG1993; Region: DUF190; cl00872
243231001602	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
243231001603	active site residue [active]
243231001604	DoxX; Region: DoxX; cl00976
243231001605	Glycerol-3-phosphate acyltransferase; Region: G3P_acyltransf; cl00410
243231001606	YceG-like family; Region: YceG; pfam02618
243231001607	proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010
243231001608	dimerization interface [polypeptide binding]; other site
243231001609	Uncharacterized anaerobic dehydrogenase [General function prediction only]; Region: COG3383
243231001610	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
243231001611	catalytic loop [active]
243231001612	iron binding site [ion binding]; other site
243231001613	NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; cl11210
243231001614	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
243231001615	molybdopterin cofactor binding site; other site
243231001616	This CD includes formate dehydrogenases (Fdh) H and N; nitrate reductases, Nap and Nas; and other related proteins. Formate dehydrogenase H is a component of the anaerobic formate hydrogen lyase complex  and catalyzes the reversible oxidation of formate...; Region: MopB_CT_Fdh-Nap-like; cd00508
243231001617	molybdopterin cofactor binding site; other site
243231001618	dihydropyrimidine dehydrogenase subunit A; Provisional; Region: PRK11749
243231001619	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
243231001620	dihydropyrimidine dehydrogenase subunit A; Provisional; Region: PRK11749
243231001621	Leucyl aminopeptidase (aminopeptidase T) [Amino acid transport and metabolism]; Region: AmpS; COG2309
243231001622	Protein of unknown function (DUF342); Region: DUF342; pfam03961
243231001623	Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237
243231001624	Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022
243231001625	CoA-binding site [chemical binding]; other site
243231001626	ATP-binding [chemical binding]; other site
243231001627	Transcriptional regulator [Transcription]; Region: IclR; COG1414
243231001628	Helix-turn-helix domains; Region: HTH; cl00088
243231001629	Bacterial transcriptional regulator; Region: IclR; pfam01614
243231001630	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
243231001631	Ligand Binding Site [chemical binding]; other site
243231001632	Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082
243231001633	AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060
243231001634	AP (apurinic/apyrimidinic) site pocket; other site
243231001635	DNA interaction; other site
243231001636	Metal-binding active site; metal-binding site
243231001637	Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401
243231001638	metal binding triad; other site
243231001639	Putative nucleotidyltransferase substrate binding domain; Region: DUF294_C; pfam10335
243231001640	Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u4; cd11480
243231001641	Na binding site [ion binding]; other site
243231001642	Domain of unknown function (DUF4212); Region: DUF4212; cl01781
243231001643	tRNA pseudouridine synthase D; Reviewed; Region: truD; PRK00984
243231001644	Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130
243231001645	active site
243231001646	Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130
243231001647	Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130
243231001648	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911
243231001649	ATP-dependent RNA helicase RhlB; Provisional; Region: PRK04837
243231001650	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
243231001651	ATP binding site [chemical binding]; other site
243231001652	Mg++ binding site [ion binding]; other site
243231001653	motif III; other site
243231001654	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
243231001655	nucleotide binding region [chemical binding]; other site
243231001656	ATP-binding site [chemical binding]; other site
243231001657	aminodeoxychorismate synthase; Provisional; Region: PRK07508
243231001658	chorismate binding enzyme; Region: Chorismate_bind; cl10555
243231001659	PyridoxaL 5'-Phosphate Dependent Enzymes class IV (PLPDE_IV). This D-amino acid superfamily, one of five classes of PLPDE, consists of branched-chain amino acid aminotransferases (BCAT), D-amino acid transferases (DAAT), and 4-amino-4-deoxychorismate...; Region: PLPDE_IV; cl00224
243231001660	substrate-cofactor binding pocket; other site
243231001661	homodimer interface [polypeptide binding]; other site
243231001662	pyridoxal 5'-phosphate binding site [chemical binding]; other site
243231001663	catalytic residue [active]
243231001664	Protein of unknown function (DUF2400); Region: DUF2400; cl09884
243231001665	D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563
243231001666	putative active site [active]
243231001667	dimerization interface [polypeptide binding]; other site
243231001668	putative tRNAtyr binding site [nucleotide binding]; other site
243231001669	Macro domain, Appr-1'-pase_like family. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ADP-ribose...; Region: Macro_Appr_pase_like; cd02908
243231001670	putative ADP-ribose binding site [chemical binding]; other site
243231001671	putative active site [active]
243231001672	Ion channel; Region: Ion_trans_2; cl11596
243231001673	K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569
243231001674	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
243231001675	Anion permease ArsB/NhaD.  These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life.  A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl15357
243231001676	K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569
243231001677	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
243231001678	Anion permease ArsB/NhaD.  These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life.  A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl15357
243231001679	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
243231001680	4Fe-4S dicluster domain; Region: Fer4_7; pfam12838
243231001681	Nitroreductase family. Members of this family utilize FMN as a cofactor. This family is involved in the reduction of flavin or nitroaromatic compounds by using NAD(P)H as electron donor in a obligatory two-electron transfer. Nitrogenase is homodimer; Region: NADH_nitroreductase; cd02143
243231001682	putative FMN binding site [chemical binding]; other site
243231001683	endonuclease IV; Provisional; Region: PRK01060
243231001684	AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019
243231001685	AP (apurinic/apyrimidinic) site pocket; other site
243231001686	DNA interaction; other site
243231001687	Metal-binding active site; metal-binding site
243231001688	HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the basis...; Region: HIT_like; cl00228
243231001689	nucleotide binding site/active site [active]
243231001690	HIT family signature motif; other site
243231001691	catalytic residue [active]
243231001692	diaminopimelate epimerase; Provisional; Region: dapF; PRK00450
243231001693	Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678
243231001694	Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678
243231001695	Helix-turn-helix domains; Region: HTH; cl00088
243231001696	Rrf2 family protein; Region: rrf2_super; TIGR00738
243231001697	Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031
243231001698	CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561
243231001699	dimer interface [polypeptide binding]; other site
243231001700	pyridoxal 5'-phosphate binding site [chemical binding]; other site
243231001701	catalytic residue [active]
243231001702	ATP-utilizing enzymes of the PP-loop superfamily [General function prediction only]; Region: COG1606
243231001703	This is a subfamily of Adenine nucleotide alpha hydrolases superfamily. Adenine nucleotide alpha hydrolases superfamily  includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which  binds to Adenosine group.  This subfamily; Region: Alpha_ANH_like_I; cd01990
243231001704	Ligand Binding Site [chemical binding]; other site
243231001705	PAS fold; Region: PAS_4; pfam08448
243231001706	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
243231001707	putative active site [active]
243231001708	heme pocket [chemical binding]; other site
243231001709	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
243231001710	metal binding site [ion binding]; metal-binding site
243231001711	active site
243231001712	I-site; other site
243231001713	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
243231001714	Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071
243231001715	Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain  (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464
243231001716	putative dimer interface [polypeptide binding]; other site
243231001717	Domain of unknown function (DUF4177); Region: DUF4177; pfam13783
243231001718	DNA polymerase I; Provisional; Region: PRK05755
243231001719	PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859
243231001720	active site
243231001721	metal binding site 1 [ion binding]; metal-binding site
243231001722	putative 5' ssDNA interaction site; other site
243231001723	metal binding site 3; metal-binding site
243231001724	metal binding site 2 [ion binding]; metal-binding site
243231001725	H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898
243231001726	putative DNA binding site [nucleotide binding]; other site
243231001727	putative metal binding site [ion binding]; other site
243231001728	DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase I and similar bacterial family-A DNA polymerases; Region: DNA_polA_I_Ecoli_like_exo; cd06139
243231001729	active site
243231001730	catalytic site [active]
243231001731	substrate binding site [chemical binding]; other site
243231001732	Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637
243231001733	active site
243231001734	DNA binding site [nucleotide binding]
243231001735	catalytic site [active]
243231001736	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
243231001737	metal binding site [ion binding]; metal-binding site
243231001738	active site
243231001739	I-site; other site
243231001740	Outer membrane lipoprotein Slp family; Region: Slp; cl01164
243231001741	Predicted O-methyltransferase [General function prediction only]; Region: COG4122
243231001742	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911
243231001743	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
243231001744	EamA-like transporter family; Region: EamA; cl01037
243231001745	RF-1 domain; Region: RF-1; cl02875
243231001746	recombination and DNA strand exchange inhibitor protein; Reviewed; Region: PRK00409
243231001747	MutS2 homologs in bacteria and eukaryotes.  The MutS protein initiates DNA mismatch repair by recognizing mispaired and unpaired bases embedded in duplex DNA and activating endo- and exonucleases to remove the mismatch. Members of the MutS family also...; Region: ABC_MutS2; cd03280
243231001748	Walker A/P-loop; other site
243231001749	ATP binding site [chemical binding]; other site
243231001750	Q-loop/lid; other site
243231001751	ABC transporter signature motif; other site
243231001752	Walker B; other site
243231001753	D-loop; other site
243231001754	H-loop/switch region; other site
243231001755	Smr domain; Region: Smr; cl02619
243231001756	Fe-S oxidoreductase [Energy production and conversion]; Region: COG1032
243231001757	B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293
243231001758	B12 binding site [chemical binding]; other site
243231001759	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
243231001760	FeS/SAM binding site; other site
243231001761	Domain of unknown function (DUF4070); Region: DUF4070; pfam13282
243231001762	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
243231001763	S-adenosylmethionine binding site [chemical binding]; other site
243231001764	Predicted transcriptional regulator [Transcription]; Region: COG4190
243231001765	RT_Bac_retron_I: Reverse transcriptases (RTs) in bacterial retrotransposons or retrons. The polymerase reaction of this enzyme leads to the production of a unique RNA-DNA complex called msDNA (multicopy single-stranded (ss)DNA) in which a small ssDNA...; Region: RT_Bac_retron_I; cd01646
243231001766	putative active site [active]
243231001767	putative NTP binding site [chemical binding]; other site
243231001768	putative nucleic acid binding site [nucleotide binding]; other site
243231001769	TIR domain; Region: TIR_2; cl15770
243231001770	Piwi-like: PIWI domain. Domain found in proteins involved in RNA silencing. RNA silencing refers to a group of related gene-silencing mechanisms mediated by short RNA molecules, including siRNAs, miRNAs, and heterochromatin-related guide RNAs. The...; Region: Piwi-like; cl00628
243231001771	5' RNA guide strand anchoring site; other site
243231001772	active site
243231001773	putative transposase OrfB; Reviewed; Region: PHA02517
243231001774	HTH-like domain; Region: HTH_21; pfam13276
243231001775	Integrase core domain; Region: rve; cl01316
243231001776	Integrase core domain; Region: rve_3; cl15866
243231001777	Piwi-like: PIWI domain. Domain found in proteins involved in RNA silencing. RNA silencing refers to a group of related gene-silencing mechanisms mediated by short RNA molecules, including siRNAs, miRNAs, and heterochromatin-related guide RNAs. The...; Region: Piwi-like; cl00628
243231001778	Transposase domain (DUF772); Region: DUF772; pfam05598
243231001779	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
243231001780	DDE superfamily endonuclease; Region: DDE_4; cl15789
243231001781	Predicted P-loop ATPase [General function prediction only]; Region: COG4928
243231001782	Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cl00161
243231001783	Double zinc ribbon; Region: DZR; pfam12773
243231001784	NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976
243231001785	catalytic residues [active]
243231001786	Methyladenine glycosylase; Region: Adenine_glyco; cl01059
243231001787	Isochorismatase family; Region: Isochorismatase; pfam00857
243231001788	Nicotinamidase_ related amidohydrolases.  Cysteine hydrolases of unknown function that share the catalytic triad with other amidohydrolases, like nicotinamidase, which converts nicotinamide to nicotinic acid and ammonia; Region: nicotinamidase_related; cd01014
243231001789	catalytic triad [active]
243231001790	conserved cis-peptide bond; other site
243231001791	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
243231001792	S-adenosylmethionine binding site [chemical binding]; other site
243231001793	Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209
243231001794	folate binding site [chemical binding]; other site
243231001795	NADP+ binding site [chemical binding]; other site
243231001796	Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419
243231001797	Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391
243231001798	Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064
243231001799	Cinnamyl alcohol dehydrogenases (CAD); Region: CAD2; cd08298
243231001800	putative NAD(P) binding site [chemical binding]; other site
243231001801	putative substrate binding site [chemical binding]; other site
243231001802	catalytic Zn binding site [ion binding]; other site
243231001803	structural Zn binding site [ion binding]; other site
243231001804	EamA-like transporter family; Region: EamA; cl01037
243231001805	Carbon starvation protein CstA; Region: CstA; pfam02554
243231001806	C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722
243231001807	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
243231001808	binding surface
243231001809	TPR motif; other site
243231001810	Recombination protein O N terminal; Region: RecO_N; cl15812
243231001811	DNA repair protein RecO; Region: reco; TIGR00613
243231001812	Recombination protein O C terminal; Region: RecO_C; pfam02565
243231001813	Class II Glycyl-tRNA synthetase (GlyRS) alpha subunit core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes and in arabidopsis. It is responsible for the...; Region: GlyRS_alpha_core; cd00733
243231001814	dimer interface [polypeptide binding]; other site
243231001815	motif 1; other site
243231001816	active site
243231001817	motif 2; other site
243231001818	motif 3; other site
243231001819	glycyl-tRNA synthetase subunit beta; Validated; Region: glyS; PRK01233
243231001820	Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020
243231001821	pyruvate phosphate dikinase; Provisional; Region: PRK09279
243231001822	Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326
243231001823	PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; cl01586
243231001824	Pyruvate kinase (PK):  Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl09155
243231001825	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box protein; Region: CSP_CDS; cd04458
243231001826	DNA-binding site [nucleotide binding]; DNA binding site
243231001827	RNA-binding motif; other site
243231001828	Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840
243231001829	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
243231001830	dimerization interface [polypeptide binding]; other site
243231001831	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
243231001832	dimer interface [polypeptide binding]; other site
243231001833	putative CheW interface [polypeptide binding]; other site
243231001834	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
243231001835	dimerization interface [polypeptide binding]; other site
243231001836	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
243231001837	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
243231001838	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
243231001839	dimer interface [polypeptide binding]; other site
243231001840	putative CheW interface [polypeptide binding]; other site
243231001841	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421
243231001842	Predicted Fe-S oxidoreductase [General function prediction only]; Region: COG1242
243231001843	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
243231001844	FeS/SAM binding site; other site
243231001845	Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564
243231001846	thiamine phosphate binding site [chemical binding]; other site
243231001847	active site
243231001848	pyrophosphate binding site [ion binding]; other site
243231001849	Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728
243231001850	ThiS interaction site; other site
243231001851	putative active site [active]
243231001852	tetramer interface [polypeptide binding]; other site
243231001853	ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565
243231001854	thiS-thiF/thiG interaction site; other site
243231001855	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
243231001856	Signal transduction histidine kinase involved in nitrogen fixation and metabolism regulation [Signal transduction mechanisms]; Region: NtrY; COG5000
243231001857	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
243231001858	dimerization interface [polypeptide binding]; other site
243231001859	c(7)-type cytochrome triheme domain; Region: nanowire_3heme; TIGR04257
243231001860	c(7)-type cytochrome triheme domain; Region: nanowire_3heme; TIGR04257
243231001861	c(7)-type cytochrome triheme domain; Region: nanowire_3heme; TIGR04257
243231001862	c(7)-type cytochrome triheme domain; Region: nanowire_3heme; TIGR04257
243231001863	Cytochrome b (N-terminus)/b6/petB:  Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859
243231001864	cytochrome c nitrite reductase, pentaheme subunit; Region: cyt_nit_nrfB; TIGR03146
243231001865	Doubled CXXCH motif (Paired_CXXCH_1); Region: Paired_CXXCH_1; cl09905
243231001866	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
243231001867	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
243231001868	active site
243231001869	phosphorylation site [posttranslational modification]
243231001870	intermolecular recognition site; other site
243231001871	dimerization interface [polypeptide binding]; other site
243231001872	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
243231001873	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
243231001874	active site
243231001875	phosphorylation site [posttranslational modification]
243231001876	intermolecular recognition site; other site
243231001877	dimerization interface [polypeptide binding]; other site
243231001878	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
243231001879	Walker A motif; other site
243231001880	ATP binding site [chemical binding]; other site
243231001881	Walker B motif; other site
243231001882	arginine finger; other site
243231001883	Helix-turn-helix domains; Region: HTH; cl00088
243231001884	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
243231001885	dimerization interface [polypeptide binding]; other site
243231001886	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
243231001887	dimer interface [polypeptide binding]; other site
243231001888	phosphorylation site [posttranslational modification]
243231001889	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
243231001890	ATP binding site [chemical binding]; other site
243231001891	Mg2+ binding site [ion binding]; other site
243231001892	G-X-G motif; other site
243231001893	Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893
243231001894	active site
243231001895	catalytic site [active]
243231001896	Phosphoenolpyruvate:glucose-phosphotransferase regulator; Region: MtfA; cl01267
243231001897	ThiC family; Region: ThiC; cl08031
243231001898	Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564
243231001899	thiamine phosphate binding site [chemical binding]; other site
243231001900	active site
243231001901	pyrophosphate binding site [ion binding]; other site
243231001902	4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169
243231001903	substrate binding site [chemical binding]; other site
243231001904	dimer interface [polypeptide binding]; other site
243231001905	ATP binding site [chemical binding]; other site
243231001906	alanine racemase; Reviewed; Region: alr; PRK00053
243231001907	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430
243231001908	active site
243231001909	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
243231001910	dimer interface [polypeptide binding]; other site
243231001911	substrate binding site [chemical binding]; other site
243231001912	catalytic residues [active]
243231001913	selenophosphate synthetase; Provisional; Region: PRK00943
243231001914	Selenophosphate synthetase  (SelD) catalyzes the conversion of selenium to selenophosphate which is required by a number of bacterial, archaeal and eukaryotic organisms for synthesis of Secys-tRNA, the precursor of selenocysteine in selenoenzymes. The...; Region: SelD; cd02195
243231001915	dimerization interface [polypeptide binding]; other site
243231001916	putative ATP binding site [chemical binding]; other site
243231001917	Uncharacterized metal-binding protein [General function prediction only]; Region: COG3894
243231001918	bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881
243231001919	Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal  ATIC formylase domain that formylates...; Region: IMPCH; cd01421
243231001920	purine monophosphate binding site [chemical binding]; other site
243231001921	dimer interface [polypeptide binding]; other site
243231001922	putative catalytic residues [active]
243231001923	AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362
243231001924	AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362
243231001925	phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885
243231001926	Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844
243231001927	ATP-grasp domain; Region: ATP-grasp_4; cl03087
243231001928	Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843
243231001929	AIR carboxylase; Region: AIRC; cl00310
243231001930	Heme-binding domain of the class III cytochrome C family and related proteins; Region: Cytochrom_C3; cd08168
243231001931	heme-binding residues [chemical binding]; other site
243231001932	ResB protein required for cytochrome c biosynthesis [Posttranslational modification, protein turnover, chaperones]; Region: ResB; cl09125
243231001933	ResB-like family; Region: ResB; pfam05140
243231001934	Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504
243231001935	Doubled CXXCH motif (Paired_CXXCH_1); Region: Paired_CXXCH_1; cl09905
243231001936	Doubled CXXCH motif (Paired_CXXCH_1); Region: Paired_CXXCH_1; cl09905
243231001937	Doubled CXXCH motif (Paired_CXXCH_1); Region: Paired_CXXCH_1; cl09905
243231001938	Doubled CXXCH motif (Paired_CXXCH_1); Region: Paired_CXXCH_1; cl09905
243231001939	Heme-binding domain of the class III cytochrome C family and related proteins; Region: Cytochrom_C3; cl03439
243231001940	decaheme c-type cytochrome, DmsE family; Region: decahem_SO; TIGR03508
243231001941	Doubled CXXCH motif (Paired_CXXCH_1); Region: Paired_CXXCH_1; cl09905
243231001942	Uncharacterized conserved protein [Function unknown]; Region: COG3391
243231001943	NHL repeat; Region: NHL; pfam01436
243231001944	Doubled CXXCH motif (Paired_CXXCH_1); Region: Paired_CXXCH_1; cl09905
243231001945	potential protein location (hypothetical protein) that overlaps protein (hypothetical protein)
243231001946	potential protein location (hypothetical protein) that overlaps protein (hypothetical protein)
243231001947	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
243231001948	active site
243231001949	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
243231001950	TPR motif; other site
243231001951	binding surface
243231001952	undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714
243231001953	Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187
243231001954	Ligand binding site; other site
243231001955	Putative Catalytic site; other site
243231001956	DXD motif; other site
243231001957	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
243231001958	Helix-turn-helix domains; Region: HTH; cl00088
243231001959	GDP-mannose 4,6-dehydratase; Region: gmd; TIGR01472
243231001960	GDP-mannose 4,6 dehydratase, extended (e) SDRs; Region: GDP_MD_SDR_e; cd05260
243231001961	NADP-binding site; other site
243231001962	homotetramer interface [polypeptide binding]; other site
243231001963	substrate binding site [chemical binding]; other site
243231001964	homodimer interface [polypeptide binding]; other site
243231001965	active site
243231001966	GDP-fucose synthetase, extended (e) SDRs; Region: GDP_FS_SDR_e; cd05239
243231001967	GDP-4-keto-6-deoxymannose-3, 5-epimerase-4-reductase; Region: PLN02725
243231001968	NADP binding site [chemical binding]; other site
243231001969	active site
243231001970	putative substrate binding site [chemical binding]; other site
243231001971	2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1, 4-benzoquinol methylase [Coenzyme metabolism]; Region: UbiG; COG2227
243231001972	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911
243231001973	MatE; Region: MatE; cl10513
243231001974	Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226
243231001975	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
243231001976	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
243231001977	Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_d; cd04196
243231001978	Probable Catalytic site; other site
243231001979	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911
243231001980	RfbF is a putative dTDP-rhamnosyl transferase; Region: GT2_RfbF_like; cd02526
243231001981	L-rhamnosyltransferase; Region: rhamnosyltran; TIGR01556
243231001982	Ligand binding site; other site
243231001983	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
243231001984	This family is most closely related to the GT1 family of glycosyltransferases. wbuB in E. coli is involved in the biosynthesis of the O26 O-antigen.  It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase; Region: GT1_wbuB_like; cd03794
243231001985	Bacterial membrane protein YfhO; Region: YfhO; pfam09586
243231001986	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
243231001987	S-adenosylmethionine binding site [chemical binding]; other site
243231001988	Protein of unknown function (DUF721); Region: DUF721; cl02324
243231001989	Protein of unknown function (DUF3343); Region: DUF3343; pfam11823
243231001990	signal recognition particle protein; Provisional; Region: PRK10867
243231001991	SRP54-type protein, helical bundle domain; Region: SRP54_N; cl03758
243231001992	The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115
243231001993	P loop; other site
243231001994	GTP binding site [chemical binding]; other site
243231001995	Signal peptide binding domain; Region: SRP_SPB; pfam02978
243231001996	Ribosomal protein S16; Region: Ribosomal_S16; cl00368
243231001997	Predicted RNA-binding protein (contains KH domain) [General function prediction only]; Region: COG1837
243231001998	KH-II  (K homology RNA-binding domain, type II). KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins  (e.g. ribosomal protein S3), transcription factors (e.g. NusA_K), and post-transcriptional...; Region: KH-II; cl00098
243231001999	16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122
243231002000	RimM N-terminal domain; Region: RimM; pfam01782
243231002001	Photosynthetic reaction center (RC) complex, subunit H;  RC is an integral membrane protein-pigment complex which catalyzes light-induced reduction of ubiquinone to ubiquinol, generating a transmembrane electrochemical gradient of protons used to produce...; Region: PRCH; cl09959
243231002002	tRNA (Guanine-1)-methyltransferase; Region: tRNA_m1G_MT; cl00407
243231002003	SpoU rRNA Methylase family; Region: SpoU_methylase; cl00362
243231002004	Ribosomal protein L19; Region: Ribosomal_L19; cl00406
243231002005	bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182
243231002006	RNA/DNA hybrid binding site [nucleotide binding]; other site
243231002007	active site
243231002008	Restriction endonuclease; Region: Mrr_cat; cl00516
243231002009	Predicted amidohydrolase [General function prediction only]; Region: COG0388
243231002010	Uncharacterized subgroup of the nitrilase superfamily (putative class 13 nitrilases); Region: nitrilase_8; cd07586
243231002011	putative active site [active]
243231002012	catalytic triad [active]
243231002013	putative dimer interface [polypeptide binding]; other site
243231002014	NAD synthase; Region: NAD_synthase; pfam02540
243231002015	NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553
243231002016	homodimer interface [polypeptide binding]; other site
243231002017	NAD binding pocket [chemical binding]; other site
243231002018	ATP binding pocket [chemical binding]; other site
243231002019	Mg binding site [ion binding]; other site
243231002020	active-site loop [active]
243231002021	Predicted methyltransferases [General function prediction only]; Region: COG0313
243231002022	Precorrin-3B methylase [Coenzyme metabolism]; Region: CobJ; cl00304
243231002023	molybdopterin biosynthesis protein MoeB; Provisional; Region: PRK05690
243231002024	ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757
243231002025	ATP binding site [chemical binding]; other site
243231002026	substrate interface [chemical binding]; other site
243231002027	Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140
243231002028	alternative sigma factor RpoH; Region: rpoH_proteo; TIGR02392
243231002029	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
243231002030	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
243231002031	DNA binding residues [nucleotide binding]
243231002032	branched-chain amino acid aminotransferase; Provisional; Region: PRK13357
243231002033	BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids  leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557
243231002034	homodimer interface [polypeptide binding]; other site
243231002035	substrate-cofactor binding pocket; other site
243231002036	catalytic residue [active]
243231002037	ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346
243231002038	Clp amino terminal domain; Region: Clp_N; pfam02861
243231002039	Clp amino terminal domain; Region: Clp_N; pfam02861
243231002040	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
243231002041	Walker A motif; other site
243231002042	ATP binding site [chemical binding]; other site
243231002043	Walker B motif; other site
243231002044	arginine finger; other site
243231002045	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
243231002046	Walker A motif; other site
243231002047	ATP binding site [chemical binding]; other site
243231002048	Walker B motif; other site
243231002049	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; cl11083
243231002050	Putative catalytic NodB homology domain of uncharacterized BH0857 protein from Bacillus halodurans and its bacterial homologs; Region: CE4_BH0857_like; cd10955
243231002051	NodB motif; other site
243231002052	putative active site [active]
243231002053	putative catalytic site [active]
243231002054	4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: PRK14614
243231002055	GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288
243231002056	ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259
243231002057	N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793
243231002058	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
243231002059	active site
243231002060	50S ribosomal protein L25/general stress protein Ctc; Reviewed; Region: PRK05618
243231002061	Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495
243231002062	5S rRNA interface [nucleotide binding]; other site
243231002063	CTC domain interface [polypeptide binding]; other site
243231002064	L16 interface [polypeptide binding]; other site
243231002065	Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462
243231002066	putative active site [active]
243231002067	catalytic residue [active]
243231002068	GTP-binding protein YchF; Reviewed; Region: PRK09601
243231002069	YchF GTPase; Region: YchF; cd01900
243231002070	G1 box; other site
243231002071	GTP/Mg2+ binding site [chemical binding]; other site
243231002072	Switch I region; other site
243231002073	G2 box; other site
243231002074	Switch II region; other site
243231002075	G3 box; other site
243231002076	G4 box; other site
243231002077	G5 box; other site
243231002078	TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867
243231002079	Ribosomal protein S6; Region: Ribosomal_S6; cl00414
243231002080	Ribosomal protein S18; Region: Ribosomal_S18; cl00373
243231002081	Predicted membrane protein (DUF2232); Region: DUF2232; cl01728
243231002082	50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137
243231002083	Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281
243231002084	Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948
243231002085	trimethylamine N-oxide reductase cytochrome c-type subunit; Provisional; Region: PRK15032
243231002086	Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564
243231002087	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
243231002088	RNA binding surface [nucleotide binding]; other site
243231002089	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
243231002090	active site
243231002091	Cytidylate kinase-like family; Region: Cytidylate_kin2; pfam13189
243231002092	Protein of unknown function (DUF3108); Region: DUF3108; pfam11306
243231002093	hybrid cluster protein; Provisional; Region: PRK05290
243231002094	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
243231002095	ACS interaction site; other site
243231002096	CODH interaction site; other site
243231002097	Hybrid cluster protein (HCP), formerly known as prismane, is thought to play a role in nitrogen metabolism but its specific function is unknown. HCP has three structural domains, an N-terminal alpha-helical domain, and two similar domains comprising a...; Region: HCP; cd01914
243231002098	hybrid metal cluster; other site
243231002099	ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591
243231002100	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
243231002101	FtsX-like permease family; Region: FtsX; cl15850
243231002102	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
243231002103	This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE).  They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255
243231002104	Walker A/P-loop; other site
243231002105	ATP binding site [chemical binding]; other site
243231002106	Q-loop/lid; other site
243231002107	ABC transporter signature motif; other site
243231002108	Walker B; other site
243231002109	D-loop; other site
243231002110	H-loop/switch region; other site
243231002111	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
243231002112	S-adenosylmethionine binding site [chemical binding]; other site
243231002113	Domain of Unknown Function (DUF748); Region: DUF748; pfam05359
243231002114	Domain of Unknown Function (DUF748); Region: DUF748; pfam05359
243231002115	Domain of Unknown Function (DUF748); Region: DUF748; pfam05359
243231002116	Domain of Unknown Function (DUF748); Region: DUF748; pfam05359
243231002117	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cl02931
243231002118	PAS fold; Region: PAS_4; pfam08448
243231002119	Histidine kinase; Region: HisKA_3; pfam07730
243231002120	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
243231002121	ATP binding site [chemical binding]; other site
243231002122	Mg2+ binding site [ion binding]; other site
243231002123	G-X-G motif; other site
243231002124	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
243231002125	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
243231002126	active site
243231002127	phosphorylation site [posttranslational modification]
243231002128	intermolecular recognition site; other site
243231002129	dimerization interface [polypeptide binding]; other site
243231002130	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
243231002131	DNA binding residues [nucleotide binding]
243231002132	dimerization interface [polypeptide binding]; other site
243231002133	Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729
243231002134	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054
243231002135	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
243231002136	dimer interface [polypeptide binding]; other site
243231002137	Methyl-accepting chemotaxis protein (MCP) signalling domain; Region: MCPsignal; pfam00015
243231002138	putative CheW interface [polypeptide binding]; other site
243231002139	CheW, a small regulator protein, unique to the chemotaxis signalling in prokaryotes and archea. CheW interacts with the histidine kinase CheA, most likely with the related regulatory domain of CheA. CheW is proposed to form signalling arrays together...; Region: CheW; cd00732
243231002140	putative CheA interaction surface; other site
243231002141	hopanoid biosynthesis associated radical SAM protein HpnH; Region: HpnH; TIGR03470
243231002142	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
243231002143	FeS/SAM binding site; other site
243231002144	Domain of unknown function (DUF3463); Region: DUF3463; pfam11946
243231002145	1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444
243231002146	Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007
243231002147	TPP-binding site; other site
243231002148	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
243231002149	PYR/PP interface [polypeptide binding]; other site
243231002150	dimer interface [polypeptide binding]; other site
243231002151	TPP binding site [chemical binding]; other site
243231002152	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
243231002153	hopanoid-associated sugar epimerase; Region: HpnA; TIGR03466
243231002154	uncharacterized subgroup of aldehyde reductase and flavonoid reductase related proteins, extended (e) SDRs; Region: AR_FR_like_1_SDR_e; cd05228
243231002155	putative NADP binding site [chemical binding]; other site
243231002156	putative substrate binding site [chemical binding]; other site
243231002157	active site
243231002158	squalene-hopene cyclase; Region: hopene_cyclase; TIGR01507
243231002159	Squalene cyclase (SQCY) domain subgroup 1; found in class II terpene cyclases that have an alpha 6 - alpha 6 barrel fold. Squalene cyclase (SQCY)  and 2,3-oxidosqualene cyclase (OSQCY) are integral membrane proteins that catalyze a cationic cyclization...; Region: SQCY_1; cd02892
243231002160	Active site cavity [active]
243231002161	catalytic acid [active]
243231002162	hopanoid biosynthesis associated RND transporter like protein HpnN; Region: HpnN; TIGR03480
243231002163	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
243231002164	S-adenosylmethionine binding site [chemical binding]; other site
243231002165	translation initiation factor Sui1; Validated; Region: PRK06824
243231002166	Homologs of eIF1/SUI1 including Escherichia coli YciH; Region: YciH_like; cd11567
243231002167	putative rRNA binding site [nucleotide binding]; other site
243231002168	Ribokinase-like subgroup B.  Found in bacteria and plants, this subgroup is part of the ribokinase/pfkB superfamily.  Its oligomerization state is unknown at this time; Region: ribokinase_group_B; cd01945
243231002169	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
243231002170	substrate binding site [chemical binding]; other site
243231002171	ATP binding site [chemical binding]; other site
243231002172	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
243231002173	PAS fold; Region: PAS_3; pfam08447
243231002174	putative active site [active]
243231002175	heme pocket [chemical binding]; other site
243231002176	PAS domain S-box; Region: sensory_box; TIGR00229
243231002177	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
243231002178	putative active site [active]
243231002179	heme pocket [chemical binding]; other site
243231002180	sensory histidine kinase AtoS; Provisional; Region: PRK11360
243231002181	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
243231002182	dimer interface [polypeptide binding]; other site
243231002183	phosphorylation site [posttranslational modification]
243231002184	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
243231002185	ATP binding site [chemical binding]; other site
243231002186	Mg2+ binding site [ion binding]; other site
243231002187	G-X-G motif; other site
243231002188	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
243231002189	haloacid dehalogenase superfamily, subfamily IA, variant 1 with third motif having Dx(3-4)D or Dx(3-4)E; Region: HAD-SF-IA-v1; TIGR01549
243231002190	active site
243231002191	motif I; other site
243231002192	motif II; other site
243231002193	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
243231002194	oxidoreductase; Validated; Region: PRK05717
243231002195	NAD(P) binding site [chemical binding]; other site
243231002196	active site
243231002197	hopanoid biosynthesis associated glycosyl transferase protein HpnI; Region: HpnI; TIGR03472
243231002198	Glucosylceramide synthase catalyzes the first glycosylation step of glycosphingolipid synthesis; Region: Glucosylceramide_synthase; cd02520
243231002199	ligand binding site; other site
243231002200	HEAT repeats; Region: HEAT_2; pfam13646
243231002201	HEAT repeats; Region: HEAT_2; pfam13646
243231002202	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
243231002203	Zn2+ binding site [ion binding]; other site
243231002204	Mg2+ binding site [ion binding]; other site
243231002205	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
243231002206	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
243231002207	active site
243231002208	phosphorylation site [posttranslational modification]
243231002209	intermolecular recognition site; other site
243231002210	dimerization interface [polypeptide binding]; other site
243231002211	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
243231002212	PAS fold; Region: PAS_3; pfam08447
243231002213	putative active site [active]
243231002214	heme pocket [chemical binding]; other site
243231002215	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
243231002216	PAS domain; Region: PAS_9; pfam13426
243231002217	putative active site [active]
243231002218	heme pocket [chemical binding]; other site
243231002219	Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cl00120
243231002220	Geobacter CxxxxCH...CXXCH motif (GSu_C4xC__C2xCH); Region: GSu_C4xC__C2xCH; cl15457
243231002221	Geobacter CxxxxCH...CXXCH motif (GSu_C4xC__C2xCH); Region: GSu_C4xC__C2xCH; cl15457
243231002222	Geobacter CxxxxCH...CXXCH motif (GSu_C4xC__C2xCH); Region: GSu_C4xC__C2xCH; cl15457
243231002223	ResB protein required for cytochrome c biosynthesis [Posttranslational modification, protein turnover, chaperones]; Region: ResB; cl09125
243231002224	Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504
243231002225	Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504
243231002226	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
243231002227	D-galactonate transporter; Region: 2A0114; TIGR00893
243231002228	putative substrate translocation pore; other site
243231002229	Small Multidrug Resistance protein; Region: Multi_Drug_Res; cl00910
243231002230	Small Multidrug Resistance protein; Region: Multi_Drug_Res; cl00910
243231002231	Predicted P-loop ATPase [General function prediction only]; Region: COG4928
243231002232	KAP family P-loop domain; Region: KAP_NTPase; pfam07693
243231002233	Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490
243231002234	putative phosphate binding site [ion binding]; other site
243231002235	Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cl02712
243231002236	Bacterial SH3 domain; Region: SH3_3; cl02551
243231002237	Caspase, interleukin-1 beta converting enzyme (ICE) homologues; Cysteine-dependent aspartate-directed proteases that mediate programmed cell death (apoptosis). Caspases are synthesized as inactive zymogens and activated by proteolysis of the peptide...; Region: CASc; cl00042
243231002238	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
243231002239	PAS domain; Region: PAS_9; pfam13426
243231002240	putative active site [active]
243231002241	heme pocket [chemical binding]; other site
243231002242	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
243231002243	dimer interface [polypeptide binding]; other site
243231002244	phosphorylation site [posttranslational modification]
243231002245	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
243231002246	ATP binding site [chemical binding]; other site
243231002247	Mg2+ binding site [ion binding]; other site
243231002248	G-X-G motif; other site
243231002249	Response regulator receiver domain; Region: Response_reg; pfam00072
243231002250	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
243231002251	active site
243231002252	phosphorylation site [posttranslational modification]
243231002253	intermolecular recognition site; other site
243231002254	dimerization interface [polypeptide binding]; other site
243231002255	Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695
243231002256	Superoxide reductase-like (SORL) domain, class II; SORL-domains are present in a family of mononuclear non-heme iron proteins that includes superoxide reductase and desulfoferrodoxin.  Superoxide reductase-like proteins scavenge superoxide anion radicals...; Region: SORL_classII; cd03172
243231002257	non-heme iron binding site [ion binding]; other site
243231002258	tetramer interface [polypeptide binding]; other site
243231002259	RNA polymerase factor sigma-70; Validated; Region: PRK09047
243231002260	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
243231002261	DNA binding residues [nucleotide binding]
243231002262	Protein of unknown function (DUF3106); Region: DUF3106; pfam11304
243231002263	Flagellin N-methylase; Region: FliB; cl00497
243231002264	CheD chemotactic sensory transduction; Region: CheD; cl00810
243231002265	Domain of unknown function (DUF3244); Region: DUF3244; pfam11589
243231002266	polyphosphate:AMP phosphotransferase; Region: poly_P_AMP_trns; TIGR03708
243231002267	Polyphosphate kinase 2 (PPK2); Region: PPK2; cl11971
243231002268	Polyphosphate kinase 2 (PPK2); Region: PPK2; cl11971
243231002269	4Fe-4S binding domain; Region: Fer4_5; pfam12801
243231002270	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
243231002271	4Fe-4S dicluster domain; Region: Fer4_9; pfam13187
243231002272	UDP-3-O-acyl-N-acetylglucosamine deacetylase [Cell envelope biogenesis, outer membrane]; Region: LpxC; cl00512
243231002273	UDP-3-O-acyl N-acetylglycosamine deacetylase; Region: LpxC; pfam03331
243231002274	nucleoside diphosphate kinase regulator; Provisional; Region: PRK05753
243231002275	Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272
243231002276	rod shape-determining protein MreB; Provisional; Region: PRK13930
243231002277	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; cl14187
243231002278	hydrogenase membrane subunit; Validated; Region: PRK08667
243231002279	Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600
243231002280	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
243231002281	active site
243231002282	phosphorylation site [posttranslational modification]
243231002283	PemK-like protein; Region: PemK; cl00995
243231002284	hydrogenase 4 subunit B; Validated; Region: PRK06521
243231002285	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; cl14187
243231002286	NADH dehydrogenase; Region: NADHdh; cl00469
243231002287	NADH-ubiquinone/plastoquinone oxidoreductase chain 4L; Region: Oxidored_q2; cl00492
243231002288	hydrogenase 4 subunit F; Validated; Region: PRK06458
243231002289	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; cl14187
243231002290	Respiratory-chain NADH dehydrogenase, 30 Kd subunit; Region: Complex1_30kDa; cl16917
243231002291	Nickel-dependent hydrogenase; Region: NiFeSe_Hases; cl00417
243231002292	formate hydrogenlyase complex iron-sulfur subunit; Provisional; Region: PRK12387
243231002293	NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; cl15792
243231002294	Bacteriocin-protection, YdeI or OmpD-Associated; Region: OmdA; pfam13376
243231002295	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
243231002296	dimerization interface [polypeptide binding]; other site
243231002297	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
243231002298	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
243231002299	dimer interface [polypeptide binding]; other site
243231002300	putative CheW interface [polypeptide binding]; other site
243231002301	Predicted metal-binding protein (DUF2284); Region: DUF2284; cl02248
243231002302	H+ Antiporter protein; Region: 2A0121; TIGR00900
243231002303	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
243231002304	putative substrate translocation pore; other site
243231002305	cyanobacterial long protein repeat; Region: swm_rep_I; TIGR02059
243231002306	Right handed beta helix region; Region: Beta_helix; pfam13229
243231002307	Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729
243231002308	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
243231002309	dimerization interface [polypeptide binding]; other site
243231002310	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
243231002311	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
243231002312	dimer interface [polypeptide binding]; other site
243231002313	putative CheW interface [polypeptide binding]; other site
243231002314	Protein of unknown function (DUF1311); Region: DUF1311; cl01530
243231002315	Membrane-bound lysozyme-inhibitor of c-type lysozyme; Region: MliC; cl01604
243231002316	Protein of unknown function (DUF554); Region: DUF554; cl00784
243231002317	putative transposase OrfB; Reviewed; Region: PHA02517
243231002318	HTH-like domain; Region: HTH_21; pfam13276
243231002319	Integrase core domain; Region: rve; cl01316
243231002320	Integrase core domain; Region: rve_3; cl15866
243231002321	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
243231002322	AAA domain; Region: AAA_22; pfam13401
243231002323	Family description; Region: UvrD_C_2; cl15862
243231002324	methyl-accepting chemotaxis protein II; Provisional; Region: PRK15048
243231002325	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
243231002326	dimerization interface [polypeptide binding]; other site
243231002327	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
243231002328	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
243231002329	dimer interface [polypeptide binding]; other site
243231002330	putative CheW interface [polypeptide binding]; other site
243231002331	Methyl-accepting chemotaxis protein (MCP) signalling domain; Region: MCPsignal; pfam00015
243231002332	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl01155
243231002333	AzlC protein; Region: AzlC; cl00570
243231002334	Predicted permeases [General function prediction only]; Region: RarD; COG2962
243231002335	EamA-like transporter family; Region: EamA; cl01037
243231002336	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
243231002337	Helix-turn-helix domains; Region: HTH; cl00088
243231002338	Yhdh and yhfp-like putative quinone oxidoreductases; Region: MDR_yhdh_yhfp; cd05280
243231002339	putative quinone oxidoreductase, YhdH/YhfP family; Region: oxido_YhdH; TIGR02823
243231002340	NADP binding site [chemical binding]; other site
243231002341	dimer interface [polypeptide binding]; other site
243231002342	NADPH-dependent FMN reductase; Region: FMN_red; cl00438
243231002343	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
243231002344	Major Facilitator Superfamily; Region: MFS_1; pfam07690
243231002345	putative substrate translocation pore; other site
243231002346	Uncharacterized Fe-S protein [Energy production and conversion]; Region: COG1600
243231002347	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
243231002348	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
243231002349	dimerization interface [polypeptide binding]; other site
243231002350	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
243231002351	dimer interface [polypeptide binding]; other site
243231002352	phosphorylation site [posttranslational modification]
243231002353	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
243231002354	ATP binding site [chemical binding]; other site
243231002355	Mg2+ binding site [ion binding]; other site
243231002356	G-X-G motif; other site
243231002357	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
243231002358	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
243231002359	active site
243231002360	phosphorylation site [posttranslational modification]
243231002361	intermolecular recognition site; other site
243231002362	dimerization interface [polypeptide binding]; other site
243231002363	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
243231002364	Walker A motif; other site
243231002365	ATP binding site [chemical binding]; other site
243231002366	Walker B motif; other site
243231002367	arginine finger; other site
243231002368	Helix-turn-helix domains; Region: HTH; cl00088
243231002369	formate dehydrogenase, alpha subunit, proteobacterial-type; Region: formate-DH-alph; TIGR01553
243231002370	Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_Formate-Dh-Na-like; cd02752
243231002371	[4Fe-4S] binding site [ion binding]; other site
243231002372	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
243231002373	Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_Formate-Dh-Na-like; cd02752
243231002374	Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_CT_Formate-Dh-Na-like; cd02792
243231002375	molybdopterin cofactor binding site; other site
243231002376	hydrogenase 2 protein HybA; Provisional; Region: PRK10882
243231002377	4Fe-4S binding domain; Region: Fer4; cl02805
243231002378	Polysulphide reductase, NrfD; Region: NrfD; cl01295
243231002379	Formate-dependent nitrite reductase, membrane component [Inorganic ion transport and metabolism]; Region: NrfD; COG3301
243231002380	FdhD/NarQ family; Region: FdhD-NarQ; cl00659
243231002381	molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317
243231002382	MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503
243231002383	GTP binding site; other site
243231002384	mttA/Hcf106 family; Region: MttA_Hcf106; cl00788
243231002385	hydrogenase 2 small subunit; Provisional; Region: PRK10468
243231002386	NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; cl15792
243231002387	hydrogenase 2 protein HybA; Provisional; Region: PRK10882
243231002388	4Fe-4S binding domain; Region: Fer4; cl02805
243231002389	Polysulphide reductase, NrfD; Region: NrfD; cl01295
243231002390	Nickel-dependent hydrogenase; Region: NiFeSe_Hases; cl00417
243231002391	Endopeptidases belonging to membrane-bound hydrogenases group. These hydrogenases transfer electrons from H2 to a cytochrome that is bound to a membrane-located complex coupling electron transfer to transmembrane proton translocation. Endopeptidase HybD...; Region: H2MP_MemB-H2up; cd06062
243231002392	putative substrate-binding site; other site
243231002393	nickel binding site [ion binding]; other site
243231002394	mttA/Hcf106 family; Region: MttA_Hcf106; cl00788
243231002395	Response regulator receiver domain; Region: Response_reg; pfam00072
243231002396	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
243231002397	active site
243231002398	phosphorylation site [posttranslational modification]
243231002399	intermolecular recognition site; other site
243231002400	dimerization interface [polypeptide binding]; other site
243231002401	Protein of unknown function (DUF2860); Region: DUF2860; pfam11059
243231002402	Flagellin N-methylase; Region: FliB; cl00497
243231002403	NRDE protein; Region: NRDE; cl01315
243231002404	NosL; Region: NosL; cl01769
243231002405	CoA-disulfide reductase; Region: CoA_CoA_reduc; TIGR03385
243231002406	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
243231002407	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
243231002408	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
243231002409	active site residue [active]
243231002410	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
243231002411	active site residue [active]
243231002412	Brown fat-inducible thioesterase (BFIT).  Brain acyl-CoA hydrolase (BACH).  These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442
243231002413	MarC family integral membrane protein; Region: MarC; cl00919
243231002414	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
243231002415	HisP and GlnQ are the ATP-binding components of the bacterial periplasmic histidine and glutamine permeases, repectively.  Histidine permease is a multisubunit complex containing the HisQ and HisM integral membrane subunits and two copies of HisP.  HisP...; Region: ABC_HisP_GlnQ_permeases; cd03262
243231002416	Walker A/P-loop; other site
243231002417	ATP binding site [chemical binding]; other site
243231002418	Q-loop/lid; other site
243231002419	ABC transporter signature motif; other site
243231002420	Walker B; other site
243231002421	D-loop; other site
243231002422	H-loop/switch region; other site
243231002423	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
243231002424	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
243231002425	dimer interface [polypeptide binding]; other site
243231002426	conserved gate region; other site
243231002427	putative PBP binding loops; other site
243231002428	ABC-ATPase subunit interface; other site
243231002429	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
243231002430	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
243231002431	substrate binding pocket [chemical binding]; other site
243231002432	membrane-bound complex binding site; other site
243231002433	hinge residues; other site
243231002434	Domain of unknown function (DUF4104); Region: DUF4104; pfam13372
243231002435	classical (c) SDRs; Region: SDR_c; cd05233
243231002436	short chain dehydrogenase; Provisional; Region: PRK07041
243231002437	NAD(P) binding site [chemical binding]; other site
243231002438	active site
243231002439	phosphoenolpyruvate synthase; Validated; Region: PRK06464
243231002440	Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326
243231002441	PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; cl01586
243231002442	Pyruvate kinase (PK):  Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl09155
243231002443	NADPH-dependent FMN reductase; Region: FMN_red; cl00438
243231002444	FxsA cytoplasmic membrane protein; Region: FxsA; cl01148
243231002445	ATP:dephospho-CoA triphosphoribosyl transferase; Region: CitG; cl00768
243231002446	Apo-citrate lyase phosphoribosyl-dephospho-CoA transferase; Region: CitX; cl01498
243231002447	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
243231002448	ligand binding site [chemical binding]; other site
243231002449	flexible hinge region; other site
243231002450	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
243231002451	metal binding site [ion binding]; metal-binding site
243231002452	active site
243231002453	I-site; other site
243231002454	Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeD; cd03379
243231002455	active site clefts [active]
243231002456	zinc binding site [ion binding]; other site
243231002457	dimer interface [polypeptide binding]; other site
243231002458	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl01155
243231002459	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
243231002460	ligand binding site [chemical binding]; other site
243231002461	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
243231002462	ligand binding site [chemical binding]; other site
243231002463	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
243231002464	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
243231002465	active site
243231002466	phosphorylation site [posttranslational modification]
243231002467	intermolecular recognition site; other site
243231002468	dimerization interface [polypeptide binding]; other site
243231002469	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
243231002470	Walker A motif; other site
243231002471	ATP binding site [chemical binding]; other site
243231002472	Walker B motif; other site
243231002473	arginine finger; other site
243231002474	Helix-turn-helix domains; Region: HTH; cl00088
243231002475	Signal transduction histidine kinase involved in nitrogen fixation and metabolism regulation [Signal transduction mechanisms]; Region: NtrY; COG5000
243231002476	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
243231002477	dimerization interface [polypeptide binding]; other site
243231002478	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459
243231002479	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
243231002480	dimer interface [polypeptide binding]; other site
243231002481	phosphorylation site [posttranslational modification]
243231002482	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
243231002483	ATP binding site [chemical binding]; other site
243231002484	Mg2+ binding site [ion binding]; other site
243231002485	G-X-G motif; other site
243231002486	Toluene tolerance, Ttg2; Region: Tol_Tol_Ttg2; cl01074
243231002487	Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538
243231002488	mce related protein; Region: MCE; pfam02470
243231002489	ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127
243231002490	ABC (ATP-binding cassette) transport system involved in resistant to organic solvents; ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars, ions, peptides, and more complex...; Region: ABC_Org_Solvent_Resistant; cd03261
243231002491	Walker A/P-loop; other site
243231002492	ATP binding site [chemical binding]; other site
243231002493	Q-loop/lid; other site
243231002494	ABC transporter signature motif; other site
243231002495	Walker B; other site
243231002496	D-loop; other site
243231002497	H-loop/switch region; other site
243231002498	Permease; Region: Permease; cl00510
243231002499	NADP+-dependent non-phosphorylating glyceraldehyde 3-phosphate dehydrogenase and ALDH family 11; Region: ALDH_F11_NP-GAPDH; cd07082
243231002500	tetrameric interface [polypeptide binding]; other site
243231002501	activator binding site; other site
243231002502	NADP binding site [chemical binding]; other site
243231002503	substrate binding site [chemical binding]; other site
243231002504	catalytic residues [active]
243231002505	This family is the oxydase domain of NRPS (non-ribosomal peptide synthetase) and other proteins that modify polypeptides by cyclizing a thioester to form a ring. These include epoB, part of the epothilone biosynthesis pathway; tubD, part of the tubulysin...; Region: mcbC-like_oxidoreductase; cd02142
243231002506	NADPH bind site [chemical binding]; other site
243231002507	putative FMN binding site [chemical binding]; other site
243231002508	signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706
243231002509	Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023
243231002510	tandem repeat interface [polypeptide binding]; other site
243231002511	oligomer interface [polypeptide binding]; other site
243231002512	active site residues [active]
243231002513	Cache domain; Region: Cache_1; pfam02743
243231002514	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054
243231002515	dimerization interface [polypeptide binding]; other site
243231002516	PAS domain S-box; Region: sensory_box; TIGR00229
243231002517	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
243231002518	putative active site [active]
243231002519	heme pocket [chemical binding]; other site
243231002520	aerobic respiration control sensor protein ArcB; Provisional; Region: PRK11091
243231002521	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
243231002522	dimer interface [polypeptide binding]; other site
243231002523	phosphorylation site [posttranslational modification]
243231002524	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
243231002525	ATP binding site [chemical binding]; other site
243231002526	Mg2+ binding site [ion binding]; other site
243231002527	G-X-G motif; other site
243231002528	PPIC-type PPIASE domain; Region: Rotamase; cl08278
243231002529	SseB protein; Region: SseB; cl06279
243231002530	Pirin-related protein [General function prediction only]; Region: COG1741
243231002531	Cupin domain; Region: Cupin_2; cl09118
243231002532	Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726
243231002533	Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538
243231002534	Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404
243231002535	Membrane Fusion Protein cluster 2 (function with RND porters); Region: 8a0102; TIGR00999
243231002536	Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404
243231002537	Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696
243231002538	Nitrogen regulatory protein P-II; Region: P-II; cl00412
243231002539	Nitrogen regulatory protein P-II; Region: P-II; smart00938
243231002540	Uncharacterized archaeal Zn-finger protein [General function prediction only]; Region: COG1326
243231002541	nucleoside diphosphate kinase regulator; Provisional; Region: PRK05753
243231002542	Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272
243231002543	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
243231002544	active site
243231002545	phosphorylation site [posttranslational modification]
243231002546	intermolecular recognition site; other site
243231002547	dimerization interface [polypeptide binding]; other site
243231002548	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
243231002549	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
243231002550	active site
243231002551	phosphorylation site [posttranslational modification]
243231002552	intermolecular recognition site; other site
243231002553	dimerization interface [polypeptide binding]; other site
243231002554	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
243231002555	Walker A motif; other site
243231002556	ATP binding site [chemical binding]; other site
243231002557	Walker B motif; other site
243231002558	arginine finger; other site
243231002559	GAF domain; Region: GAF_2; pfam13185
243231002560	GAF domain; Region: GAF; cl15785
243231002561	Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852
243231002562	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
243231002563	putative active site [active]
243231002564	heme pocket [chemical binding]; other site
243231002565	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
243231002566	dimer interface [polypeptide binding]; other site
243231002567	phosphorylation site [posttranslational modification]
243231002568	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
243231002569	ATP binding site [chemical binding]; other site
243231002570	Mg2+ binding site [ion binding]; other site
243231002571	G-X-G motif; other site
243231002572	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
243231002573	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
243231002574	active site
243231002575	phosphorylation site [posttranslational modification]
243231002576	intermolecular recognition site; other site
243231002577	dimerization interface [polypeptide binding]; other site
243231002578	CoA-disulfide reductase; Region: CoA_CoA_reduc; TIGR03385
243231002579	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
243231002580	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
243231002581	Permease SLC13 (solute carrier 13).  The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115
243231002582	transmembrane helices; other site
243231002583	Anion permease ArsB/NhaD.  These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life.  A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl15357
243231002584	Anion permease ArsB/NhaD.  These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life.  A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl15357
243231002585	Permease SLC13 (solute carrier 13).  The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115
243231002586	Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467
243231002587	iron-sulfur cluster [ion binding]; other site
243231002588	[2Fe-2S] cluster binding site [ion binding]; other site
243231002589	aconitate hydratase; Validated; Region: PRK09277
243231002590	Aconitase catalytic domain; Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: Aconitase; cl00285
243231002591	substrate binding site [chemical binding]; other site
243231002592	Aconitase catalytic domain; Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: Aconitase; cl00285
243231002593	ligand binding site [chemical binding]; other site
243231002594	Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580
243231002595	substrate binding site [chemical binding]; other site
243231002596	Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730
243231002597	Rubredoxin; Region: Rubredoxin; pfam00301
243231002598	iron binding site [ion binding]; other site
243231002599	4Fe-4S single cluster domain; Region: Fer4_15; pfam13459
243231002600	Domain of unknown function (DUF1858); Region: DUF1858; cl14817
243231002601	iron-sulfur cluster repair di-iron protein; Region: FeS_repair_RIC; TIGR03652
243231002602	Hemerythrin (Hr) is a non-heme diiron oxygen transport protein found in four marine invertebrate phyla including priapulida, brachiopoda, sipunculida, and annelida, as well as in protozoa. Myohemerythrin (Mhr), a hemerythrin homolog, is found in the...; Region: Hemerythrin; cl15774
243231002603	DsbA family, DsbC and DsbG subfamily; V-shaped homodimeric proteins containing a redox active CXXC motif imbedded in a TRX fold. They function as protein disulfide isomerases and chaperones in the bacterial periplasm to correct non-native disulfide bonds...; Region: DsbA_DsbC_DsbG; cd03020
243231002604	dimerization domain [polypeptide binding]; other site
243231002605	dimer interface [polypeptide binding]; other site
243231002606	catalytic residues [active]
243231002607	Rhomboid family; Region: Rhomboid; cl11446
243231002608	Domain of unknown function DUF21; Region: DUF21; pfam01595
243231002609	Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253
243231002610	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
243231002611	Transporter associated domain; Region: CorC_HlyC; cl08393
243231002612	pheromone autoinducer 2 transporter; Reviewed; Region: tqsA; cl00465
243231002613	Domain of unknown function DUF20; Region: UPF0118; pfam01594
243231002614	Integral membrane protein TerC family; Region: TerC; cl10468
243231002615	Peptidase family M48; Region: Peptidase_M48; cl12018
243231002616	Predicted membrane protein [Function unknown]; Region: COG2119
243231002617	Uncharacterized protein family UPF0016; Region: UPF0016; pfam01169
243231002618	Uncharacterized protein family UPF0016; Region: UPF0016; pfam01169
243231002619	Periplasmic protein TonB, links inner and outer membranes [Cell envelope biogenesis, outer membrane]; Region: TonB; COG0810
243231002620	Gram-negative bacterial tonB protein; Region: TonB; cl10048
243231002621	Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541
243231002622	active site
243231002623	tetramer interface; other site
243231002624	Methylenetetrahydrofolate reductase; Region: MTHFR; pfam02219
243231002625	Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537
243231002626	FAD binding site [chemical binding]; other site
243231002627	Methylene-tetrahydrofolate reductase C terminal; Region: MTHFR_C; pfam12225
243231002628	bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14190
243231002629	Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763
243231002630	NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080
243231002631	homodimer interface [polypeptide binding]; other site
243231002632	NADP binding site [chemical binding]; other site
243231002633	substrate binding site [chemical binding]; other site
243231002634	putative regulatory protein, FmdB family; Region: CxxC_CxxC_SSSS; TIGR02605
243231002635	Zinc ribbon domain; Region: CxxC_CxxC_SSSS; cl00993
243231002636	Uncharacterized ACR, YggU family COG1872; Region: DUF167; cl00811
243231002637	DivIVA protein; Region: DivIVA; pfam05103
243231002638	DivIVA domain; Region: DivI1A_domain; TIGR03544
243231002639	YGGT family; Region: YGGT; cl00508
243231002640	Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226
243231002641	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
243231002642	S-adenosylmethionine binding site [chemical binding]; other site
243231002643	Uncharacterized conserved protein [Function unknown]; Region: COG1624
243231002644	DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457
243231002645	YbbR-like protein; Region: YbbR; pfam07949
243231002646	YbbR-like protein; Region: YbbR; pfam07949
243231002647	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
243231002648	FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388
243231002649	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
243231002650	NlpC/P60 family; Region: NLPC_P60; cl11438
243231002651	The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425
243231002652	active site
243231002653	8-oxo-dGMP binding site [chemical binding]; other site
243231002654	nudix motif; other site
243231002655	metal binding site [ion binding]; metal-binding site
243231002656	B12 binding domain_like associated with radical SAM domain. This domain shows similarity with B12 (adenosylcobamide) binding domains found in several enzymes, such as glutamate mutase, methionine synthase and methylmalonyl-CoA mutase, but it lacks the...; Region: radical_SAM_B12_BD; cd02068
243231002657	Elongator protein 3, MiaB family, Radical SAM; Region: Elp3; smart00729
243231002658	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
243231002659	FeS/SAM binding site; other site
243231002660	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
243231002661	TPR motif; other site
243231002662	TPR repeat; Region: TPR_11; pfam13414
243231002663	binding surface
243231002664	potential protein location (hypothetical protein) that overlaps protein (lipoprotein, )
243231002665	Uncharacterized protein involved in outer membrane biogenesis [Cell envelope biogenesis, outer membrane]; Region: AsmA; COG2982
243231002666	Domain of Unknown Function (DUF748); Region: DUF748; pfam05359
243231002667	TIGR02099 family protein; Region: TIGR02099
243231002668	AsmA-like C-terminal region; Region: AsmA_2; cl15864
243231002669	Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597
243231002670	Diacylglycerol kinase catalytic domain; Region: DAGK_cat; cl01255
243231002671	Hydroxymethylglutaryl-coenzyme A (HMG-CoA) reductase (HMGR); Region: HMG-CoA_reductase; cl00205
243231002672	Response regulator receiver domain; Region: Response_reg; pfam00072
243231002673	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
243231002674	active site
243231002675	phosphorylation site [posttranslational modification]
243231002676	intermolecular recognition site; other site
243231002677	dimerization interface [polypeptide binding]; other site
243231002678	PilZ domain; Region: PilZ; cl01260
243231002679	GT_2_like_a represents a glycosyltransferase family-2 subfamily with unknown function; Region: GT_2_like_a; cd02522
243231002680	transferase 2, rSAM/selenodomain-associated; Region: glyco_like_mftF; TIGR04283
243231002681	Probable Catalytic site; other site
243231002682	CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256
243231002683	Response regulator receiver domain; Region: Response_reg; pfam00072
243231002684	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
243231002685	active site
243231002686	phosphorylation site [posttranslational modification]
243231002687	intermolecular recognition site; other site
243231002688	dimerization interface [polypeptide binding]; other site
243231002689	Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243
243231002690	The MopB_3 CD includes a group of related uncharacterized bacterial and archaeal molybdopterin-binding oxidoreductase-like domains with a putative N-terminal iron-sulfur [4Fe-4S] cluster binding site and molybdopterin cofactor binding site. These members...; Region: MopB_3; cd02766
243231002691	putative [4Fe-4S] binding site [ion binding]; other site
243231002692	putative molybdopterin cofactor binding site [chemical binding]; other site
243231002693	The MopB_CT_3 CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative N-terminal iron-sulfur [4Fe-4S] cluster binding site and molybdopterin cofactor binding site. This CD is of the...; Region: MopB_CT_3; cd02786
243231002694	putative molybdopterin cofactor binding site; other site
243231002695	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
243231002696	dimerization interface [polypeptide binding]; other site
243231002697	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
243231002698	dimer interface [polypeptide binding]; other site
243231002699	phosphorylation site [posttranslational modification]
243231002700	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
243231002701	ATP binding site [chemical binding]; other site
243231002702	Mg2+ binding site [ion binding]; other site
243231002703	G-X-G motif; other site
243231002704	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
243231002705	TonB-dependent heme/hemoglobin receptor family protein; Region: TonB-hemin; TIGR01785
243231002706	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
243231002707	N-terminal plug; other site
243231002708	ligand-binding site [chemical binding]; other site
243231002709	putative geopeptide radical SAM maturase; Region: geopep_mat_rSAM; TIGR04280
243231002710	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
243231002711	FeS/SAM binding site; other site
243231002712	Domain of unknown function (DUF4008); Region: DUF4008; cl14869
243231002713	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
243231002714	AAA domain; Region: AAA_26; pfam13500
243231002715	DRTGG domain; Region: DRTGG; cl12147
243231002716	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
243231002717	Radical SAM superfamily; Region: Radical_SAM; pfam04055
243231002718	FeS/SAM binding site; other site
243231002719	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
243231002720	Acylphosphatase; Region: Acylphosphatase; cl00551
243231002721	NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956
243231002722	NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114
243231002723	nucleotide binding pocket [chemical binding]; other site
243231002724	K-X-D-G motif; other site
243231002725	catalytic site [active]
243231002726	NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120
243231002727	NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119
243231002728	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786
243231002729	Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027
243231002730	Dimer interface [polypeptide binding]; other site
243231002731	BRCT sequence motif; other site
243231002732	Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459
243231002733	active site
243231002734	catalytic residues [active]
243231002735	Fibronectin type III-like domain; Region: Fn3-like; cl15273
243231002736	Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450
243231002737	Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015
243231002738	dimer interface [polypeptide binding]; other site
243231002739	decamer (pentamer of dimers) interface [polypeptide binding]; other site
243231002740	catalytic triad [active]
243231002741	peroxidatic and resolving cysteines [active]
243231002742	peptidyl-prolyl cis-trans isomerase B (rotamase B); Provisional; Region: PRK10791
243231002743	cyclophilin_EcCYP_like: cyclophilin-type A-like peptidylprolyl cis- trans isomerase (PPIase) domain similar to the cytosolic E. coli cyclophilin A and Streptomyces antibioticus SanCyp18. Compared to the archetypal cyclophilin Human cyclophilin A, these...; Region: cyclophilin_EcCYP_like; cd01920
243231002744	substrate binding site [chemical binding]; other site
243231002745	Sensory domain found in PocR; Region: PocR; pfam10114
243231002746	GAF domain; Region: GAF_2; pfam13185
243231002747	GAF domain; Region: GAF; cl15785
243231002748	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
243231002749	metal binding site [ion binding]; metal-binding site
243231002750	active site
243231002751	I-site; other site
243231002752	Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; cl00398
243231002753	Putative modulator of DNA gyrase; Region: PmbA_TldD; pfam01523
243231002754	Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; cl15394
243231002755	ATP-dependent DNA helicase RecQ; Provisional; Region: PRK11057
243231002756	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
243231002757	ATP binding site [chemical binding]; other site
243231002758	putative Mg++ binding site [ion binding]; other site
243231002759	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
243231002760	nucleotide binding region [chemical binding]; other site
243231002761	ATP-binding site [chemical binding]; other site
243231002762	RQC domain; Region: RQC; cl09632
243231002763	HRDC domain; Region: HRDC; cl02578
243231002764	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4399
243231002765	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4399
243231002766	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911
243231002767	HDOD domain; Region: HDOD; pfam08668
243231002768	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076
243231002769	Ribosomal protein S21; Region: Ribosomal_S21; cl00529
243231002770	hypothetical protein; Provisional; Region: PRK08328
243231002771	ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757
243231002772	ATP binding site [chemical binding]; other site
243231002773	substrate interface [chemical binding]; other site
243231002774	Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754
243231002775	MoaE interaction surface [polypeptide binding]; other site
243231002776	MoeB interaction surface [polypeptide binding]; other site
243231002777	thiocarboxylated glycine; other site
243231002778	NAD(P)H-nitrite reductase [Energy production and conversion]; Region: NirB; COG1251
243231002779	Aldehyde:ferredoxin oxidoreductase [Energy production and conversion]; Region: COG2414
243231002780	Aldehyde ferredoxin oxidoreductase, N-terminal domain; Region: AFOR_N; cl08354
243231002781	Aldehyde ferredoxin oxidoreductase, domains 2 & 3; Region: AFOR_C; pfam01314
243231002782	Fe-S-cluster-containing hydrogenase components 1 [Energy production and conversion]; Region: HybA; COG0437
243231002783	4Fe-4S binding domain; Region: Fer4; cl02805
243231002784	ABC transporter ATPase component; Reviewed; Region: PRK11147
243231002785	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
243231002786	Walker A/P-loop; other site
243231002787	ATP binding site [chemical binding]; other site
243231002788	Q-loop/lid; other site
243231002789	ABC transporter signature motif; other site
243231002790	Walker B; other site
243231002791	D-loop; other site
243231002792	H-loop/switch region; other site
243231002793	ABC transporter; Region: ABC_tran_2; pfam12848
243231002794	ABCF_EF-3  Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth.  EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221
243231002795	ATP-dependent RNA helicase RhlB; Provisional; Region: PRK04837
243231002796	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
243231002797	ATP binding site [chemical binding]; other site
243231002798	Mg++ binding site [ion binding]; other site
243231002799	motif III; other site
243231002800	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
243231002801	nucleotide binding region [chemical binding]; other site
243231002802	ATP-binding site [chemical binding]; other site
243231002803	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054
243231002804	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
243231002805	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
243231002806	dimer interface [polypeptide binding]; other site
243231002807	putative CheW interface [polypeptide binding]; other site
243231002808	Protein of unknown function (DUF454); Region: DUF454; cl01063
243231002809	S-adenosylmethionine synthetase; Provisional; Region: PRK04439
243231002810	ribonuclease, Rne/Rng family; Region: RNaseEG; TIGR00757
243231002811	S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453
243231002812	homodimer interface [polypeptide binding]; other site
243231002813	oligonucleotide binding site [chemical binding]; other site
243231002814	ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488
243231002815	ABCF_EF-3  Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth.  EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221
243231002816	ABCF_EF-3  Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth.  EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221
243231002817	ABC transporter; Region: ABC_tran_2; pfam12848
243231002818	ABCF_EF-3  Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth.  EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221
243231002819	ABC transporter; Region: ABC_tran_2; pfam12848
243231002820	ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466
243231002821	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
243231002822	Walker A motif; other site
243231002823	ATP binding site [chemical binding]; other site
243231002824	Walker B motif; other site
243231002825	arginine finger; other site
243231002826	Subunit ChlI of Mg-chelatase; Region: ChlI; cl12214
243231002827	Permease; Region: Permease; cl00510
243231002828	ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127
243231002829	ABC (ATP-binding cassette) transport system involved in resistant to organic solvents; ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars, ions, peptides, and more complex...; Region: ABC_Org_Solvent_Resistant; cd03261
243231002830	Walker A/P-loop; other site
243231002831	ATP binding site [chemical binding]; other site
243231002832	Q-loop/lid; other site
243231002833	ABC transporter signature motif; other site
243231002834	Walker B; other site
243231002835	D-loop; other site
243231002836	H-loop/switch region; other site
243231002837	ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463
243231002838	mce related protein; Region: MCE; pfam02470
243231002839	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
243231002840	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
243231002841	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
243231002842	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
243231002843	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
243231002844	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
243231002845	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
243231002846	active site residue [active]
243231002847	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
243231002848	active site residue [active]
243231002849	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125
243231002850	active site residue [active]
243231002851	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
243231002852	active site residue [active]
243231002853	YceI-like domain; Region: YceI; cl01001
243231002854	uracil-xanthine permease; Region: ncs2; TIGR00801
243231002855	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
243231002856	active site
243231002857	chaperone protein DnaJ; Provisional; Region: PRK14287
243231002858	Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840
243231002859	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054
243231002860	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
243231002861	dimer interface [polypeptide binding]; other site
243231002862	putative CheW interface [polypeptide binding]; other site
243231002863	Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741
243231002864	GMP synthase - Glutamine amidotransferase domain [Nucleotide transport and metabolism]; Region: GuaA; COG0518
243231002865	catalytic triad [active]
243231002866	trans-homoaconitate synthase; Reviewed; Region: aksA; PRK11858
243231002867	Streptomyces rubellomurinus FrbC and related proteins, catalytic TIM barrel domain; Region: DRE_TIM_NifV; cd07939
243231002868	active site
243231002869	catalytic residues [active]
243231002870	metal binding site [ion binding]; metal-binding site
243231002871	Nitrogen regulatory protein P-II; Region: P-II; cl00412
243231002872	Nitrogen regulatory protein P-II; Region: P-II; smart00938
243231002873	Ammonium Transporter Family; Region: Ammonium_transp; cl03012
243231002874	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
243231002875	dimer interface [polypeptide binding]; other site
243231002876	phosphorylation site [posttranslational modification]
243231002877	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
243231002878	ATP binding site [chemical binding]; other site
243231002879	Mg2+ binding site [ion binding]; other site
243231002880	G-X-G motif; other site
243231002881	IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639
243231002882	active site
243231002883	dimerization interface [polypeptide binding]; other site
243231002884	PilZ domain; Region: PilZ; cl01260
243231002885	Cys/Met metabolism PLP-dependent enzyme; Region: Cys_Met_Meta_PP; pfam01053
243231002886	CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614
243231002887	homodimer interface [polypeptide binding]; other site
243231002888	substrate-cofactor binding pocket; other site
243231002889	pyridoxal 5'-phosphate binding site [chemical binding]; other site
243231002890	catalytic residue [active]
243231002891	cystathionine beta-lyase; Provisional; Region: PRK08064
243231002892	CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614
243231002893	homodimer interface [polypeptide binding]; other site
243231002894	substrate-cofactor binding pocket; other site
243231002895	pyridoxal 5'-phosphate binding site [chemical binding]; other site
243231002896	catalytic residue [active]
243231002897	Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729
243231002898	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
243231002899	dimerization interface [polypeptide binding]; other site
243231002900	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
243231002901	PAS domain; Region: PAS_9; pfam13426
243231002902	putative active site [active]
243231002903	heme pocket [chemical binding]; other site
243231002904	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
243231002905	metal binding site [ion binding]; metal-binding site
243231002906	active site
243231002907	I-site; other site
243231002908	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
243231002909	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
243231002910	This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE).  They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255
243231002911	Walker A/P-loop; other site
243231002912	ATP binding site [chemical binding]; other site
243231002913	Q-loop/lid; other site
243231002914	ABC transporter signature motif; other site
243231002915	Walker B; other site
243231002916	D-loop; other site
243231002917	H-loop/switch region; other site
243231002918	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
243231002919	FtsX-like permease family; Region: FtsX; cl15850
243231002920	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
243231002921	Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404
243231002922	Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404
243231002923	type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844
243231002924	Signal transduction histidine kinase regulating citrate/malate metabolism [Signal transduction mechanisms]; Region: CitA; COG3290
243231002925	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
243231002926	metal binding site [ion binding]; metal-binding site
243231002927	active site
243231002928	I-site; other site
243231002929	Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383
243231002930	Transposase IS200 like; Region: Y1_Tnp; cl00848
243231002931	C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cl07055
243231002932	DnaA box-binding interface [nucleotide binding]; other site
243231002933	RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651
243231002934	Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078
243231002935	putative active site [active]
243231002936	putative NTP binding site [chemical binding]; other site
243231002937	putative nucleic acid binding site [nucleotide binding]; other site
243231002938	Group II intron, maturase-specific domain; Region: GIIM; pfam08388
243231002939	Domain of unknown function (DUF4372); Region: DUF4372; pfam14294
243231002940	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
243231002941	FOG: Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3385
243231002942	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
243231002943	Transposase; Region: DEDD_Tnp_IS110; pfam01548
243231002944	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
243231002945	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4564
243231002946	Cache domain; Region: Cache_2; cl07034
243231002947	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4564
243231002948	Cache domain; Region: Cache_2; cl07034
243231002949	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
243231002950	dimerization interface [polypeptide binding]; other site
243231002951	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
243231002952	dimer interface [polypeptide binding]; other site
243231002953	phosphorylation site [posttranslational modification]
243231002954	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
243231002955	ATP binding site [chemical binding]; other site
243231002956	Mg2+ binding site [ion binding]; other site
243231002957	G-X-G motif; other site
243231002958	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
243231002959	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
243231002960	active site
243231002961	phosphorylation site [posttranslational modification]
243231002962	intermolecular recognition site; other site
243231002963	dimerization interface [polypeptide binding]; other site
243231002964	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
243231002965	Walker A motif; other site
243231002966	ATP binding site [chemical binding]; other site
243231002967	Walker B motif; other site
243231002968	arginine finger; other site
243231002969	Helix-turn-helix domains; Region: HTH; cl00088
243231002970	potential protein location (hypothetical protein) that overlaps protein (hypothetical protein)
243231002971	potential protein location (hypothetical protein) that overlaps protein (hypothetical protein)
243231002972	C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526
243231002973	C-terminal peptidase (prc); Region: prc; TIGR00225
243231002974	PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988
243231002975	protein binding site [polypeptide binding]; other site
243231002976	C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560
243231002977	Catalytic dyad [active]
243231002978	Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647
243231002979	RF-1 domain; Region: RF-1; cl02875
243231002980	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
243231002981	ATPases of the AAA+ class [Posttranslational modification, protein turnover, chaperones]; Region: SpoVK; COG0464
243231002982	ABC transporter signature motif; other site
243231002983	Walker B; other site
243231002984	D-loop; other site
243231002985	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
243231002986	Walker A motif; other site
243231002987	ATP binding site [chemical binding]; other site
243231002988	Walker B motif; other site
243231002989	arginine finger; other site
243231002990	Protein of unknown function (DUF4255); Region: DUF4255; pfam14065
243231002991	Phage tail sheath protein; Region: Phage_sheath_1; cl01389
243231002992	Phage tail sheath protein; Region: Phage_sheath_1; cl01389
243231002993	T4-like virus tail tube protein gp19; Region: Phage_T4_gp19; cl12125
243231002994	T4-like virus tail tube protein gp19; Region: Phage_T4_gp19; cl12125
243231002995	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cl00107
243231002996	Phage late control gene D protein (GPD); Region: Phage_GPD; cl15796
243231002997	Uncharacterized protein conserved in bacteria [Function unknown]; Region: VgrG; COG3501
243231002998	Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717
243231002999	PAAR motif; Region: PAAR_motif; cl15808
243231003000	Gene 25-like lysozyme; Region: GPW_gp25; cl01403
243231003001	Baseplate J-like protein; Region: Baseplate_J; cl01294
243231003002	Baseplate J-like protein; Region: Baseplate_J; cl01294
243231003003	Baseplate J-like protein; Region: Baseplate_J; cl01294
243231003004	NHL repeat; Region: NHL; pfam01436
243231003005	Phage tail protein (Tail_P2_I); Region: Tail_P2_I; cl01817
243231003006	DNA repair and recombination protein RadA; Validated; Region: radA; PRK04301
243231003007	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
243231003008	This family is most closely related to the GT1 family of glycosyltransferases. ExpC in Rhizobium meliloti has been shown to be involved in the biosynthesis of galactoglucan (exopolysaccharide II); Region: GT1_ExpC_like; cd03818
243231003009	putative ADP-binding pocket [chemical binding]; other site
243231003010	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
243231003011	CoenzymeA binding site [chemical binding]; other site
243231003012	subunit interaction site [polypeptide binding]; other site
243231003013	PHB binding site; other site
243231003014	fumarate hydratase; Provisional; Region: PRK15389
243231003015	Fumarate hydratase (Fumerase); Region: Fumerase; cl00851
243231003016	Fumarase C-terminus; Region: Fumerase_C; cl00795
243231003017	Rho termination factor, N-terminal domain; Region: Rho_N; cl06505
243231003018	formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103
243231003019	N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966
243231003020	DNA binding site [nucleotide binding]
243231003021	catalytic residue [active]
243231003022	H2TH interface [polypeptide binding]; other site
243231003023	putative catalytic residues [active]
243231003024	turnover-facilitating residue; other site
243231003025	intercalation triad [nucleotide binding]; other site
243231003026	8OG recognition residue [nucleotide binding]; other site
243231003027	putative reading head residues; other site
243231003028	Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831
243231003029	Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827
243231003030	replicative DNA helicase; Region: DnaB; TIGR00665
243231003031	DnaB-like helicase N terminal domain; Region: DnaB; pfam00772
243231003032	DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the  chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984
243231003033	Walker A motif; other site
243231003034	ATP binding site [chemical binding]; other site
243231003035	Walker B motif; other site
243231003036	DNA binding loops [nucleotide binding]
243231003037	UDP-N-acetylglucosamine acyltransferase; Provisional; Region: PRK12461
243231003038	UDP-N-acetylglucosamine O-acyltransferase (UDP-GlcNAc acyltransferase): Proteins in this family catalyze the transfer of (R)-3-hydroxymyristic acid from its acyl carrier protein thioester to UDP-GlcNAc. It is the first enzyme in the lipid A biosynthetic...; Region: LbH_UDP-GlcNAc_AT; cd03351
243231003039	active site
243231003040	Isochorismatase family; Region: Isochorismatase; pfam00857
243231003041	YcaC related amidohydrolases; E.coli YcaC is an homooctameric hydrolase with unknown specificity. Despite its weak sequence similarity, it is structurally related to other amidohydrolases and shares conserved active site residues with them; Region: YcaC_related; cd01012
243231003042	catalytic triad [active]
243231003043	dimer interface [polypeptide binding]; other site
243231003044	conserved cis-peptide bond; other site
243231003045	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
243231003046	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
243231003047	active site
243231003048	phosphorylation site [posttranslational modification]
243231003049	intermolecular recognition site; other site
243231003050	dimerization interface [polypeptide binding]; other site
243231003051	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
243231003052	Walker A motif; other site
243231003053	ATP binding site [chemical binding]; other site
243231003054	Walker B motif; other site
243231003055	arginine finger; other site
243231003056	Helix-turn-helix domains; Region: HTH; cl00088
243231003057	nitrogen regulation protein NR(II); Provisional; Region: glnL; PRK11073
243231003058	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459
243231003059	putative active site [active]
243231003060	heme pocket [chemical binding]; other site
243231003061	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
243231003062	phosphorylation site [posttranslational modification]
243231003063	dimer interface [polypeptide binding]; other site
243231003064	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
243231003065	ATP binding site [chemical binding]; other site
243231003066	Mg2+ binding site [ion binding]; other site
243231003067	G-X-G motif; other site
243231003068	putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737
243231003069	Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801
243231003070	FMN binding site [chemical binding]; other site
243231003071	active site
243231003072	catalytic residues [active]
243231003073	substrate binding site [chemical binding]; other site
243231003074	GAF domain; Region: GAF_2; pfam13185
243231003075	GAF domain; Region: GAF; cl15785
243231003076	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
243231003077	GAF domain; Region: GAF; cl15785
243231003078	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
243231003079	Zn2+ binding site [ion binding]; other site
243231003080	Mg2+ binding site [ion binding]; other site
243231003081	Enoyl-[acyl-carrier-protein]; Region: FabI; COG0623
243231003082	Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372
243231003083	NAD binding site [chemical binding]; other site
243231003084	homotetramer interface [polypeptide binding]; other site
243231003085	homodimer interface [polypeptide binding]; other site
243231003086	substrate binding site [chemical binding]; other site
243231003087	active site
243231003088	GTP-binding protein HflX; Region: GTP_HflX; TIGR03156
243231003089	GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167
243231003090	HflX GTPase family; Region: HflX; cd01878
243231003091	G1 box; other site
243231003092	GTP/Mg2+ binding site [chemical binding]; other site
243231003093	Switch I region; other site
243231003094	G2 box; other site
243231003095	G3 box; other site
243231003096	Switch II region; other site
243231003097	G4 box; other site
243231003098	G5 box; other site
243231003099	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic 'goose-type' lysozymes (GEWL).  LTs catalyze...; Region: LT_GEWL; cd00254
243231003100	N-acetyl-D-glucosamine binding site [chemical binding]; other site
243231003101	catalytic residue [active]
243231003102	FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388
243231003103	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
243231003104	FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388
243231003105	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
243231003106	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
243231003107	binding surface
243231003108	TPR motif; other site
243231003109	Protein of unknown function (DUF401); Region: DUF401; cl00830
243231003110	hypothetical protein; Validated; Region: PRK09039
243231003111	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
243231003112	ligand binding site [chemical binding]; other site
243231003113	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2840
243231003114	Smr domain; Region: Smr; cl02619
243231003115	putative transporter; Validated; Region: PRK03818
243231003116	Predicted Permease Membrane Region; Region: Asp-Al_Ex; cl06061
243231003117	Anion permease ArsB/NhaD.  These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life.  A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl15357
243231003118	Anion permease ArsB/NhaD.  These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life.  A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl15357
243231003119	Predicted Permease Membrane Region; Region: Asp-Al_Ex; cl06061
243231003120	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
243231003121	active site
243231003122	Xanthine/uracil/vitamin C permease [Nucleotide transport and    metabolism]; Region: COG2252
243231003123	glycogen synthase; Provisional; Region: glgA; PRK00654
243231003124	This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791
243231003125	ADP-binding pocket [chemical binding]; other site
243231003126	homodimer interface [polypeptide binding]; other site
243231003127	Heme-binding domain of the class III cytochrome C family and related proteins; Region: Cytochrom_C3; cd08168
243231003128	heme-binding residues [chemical binding]; other site
243231003129	Protein of unknown function (DUF2721); Region: DUF2721; pfam11026
243231003130	N-carbamolyputrescine amidase; Region: PLN02747
243231003131	N-carbamoylputrescine amidohydrolase (CPA) (class 11 nitrilases); Region: CPA; cd07573
243231003132	putative active site; other site
243231003133	catalytic triad [active]
243231003134	putative dimer interface [polypeptide binding]; other site
243231003135	agmatine deiminase; Region: agmatine_aguA; TIGR03380
243231003136	Porphyromonas-type peptidyl-arginine deiminase; Region: PAD_porph; cl01113
243231003137	Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729
243231003138	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
243231003139	dimerization interface [polypeptide binding]; other site
243231003140	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
243231003141	dimer interface [polypeptide binding]; other site
243231003142	putative CheW interface [polypeptide binding]; other site
243231003143	Cache domain; Region: Cache_2; cl07034
243231003144	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
243231003145	dimerization interface [polypeptide binding]; other site
243231003146	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
243231003147	dimer interface [polypeptide binding]; other site
243231003148	Methyl-accepting chemotaxis protein (MCP) signalling domain; Region: MCPsignal; pfam00015
243231003149	putative CheW interface [polypeptide binding]; other site
243231003150	methyl-accepting chemotaxis protein II; Provisional; Region: PRK15048
243231003151	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
243231003152	dimerization interface [polypeptide binding]; other site
243231003153	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
243231003154	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
243231003155	dimer interface [polypeptide binding]; other site
243231003156	putative CheW interface [polypeptide binding]; other site
243231003157	MCP-signal associated domain; Region: MCPsignal_assoc; pfam13682
243231003158	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
243231003159	dimerization interface [polypeptide binding]; other site
243231003160	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
243231003161	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
243231003162	dimer interface [polypeptide binding]; other site
243231003163	putative CheW interface [polypeptide binding]; other site
243231003164	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: VicK; COG5002
243231003165	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
243231003166	dimerization interface [polypeptide binding]; other site
243231003167	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
243231003168	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
243231003169	dimer interface [polypeptide binding]; other site
243231003170	putative CheW interface [polypeptide binding]; other site
243231003171	CHASE domain; Region: CHASE; cl01369
243231003172	SGF29 tudor-like domain; Region: DUF1325; pfam07039
243231003173	chromosome segregation protein SMC, primarily archaeal type; Region: SMC_prok_A; TIGR02169
243231003174	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
243231003175	dimer interface [polypeptide binding]; other site
243231003176	phosphorylation site [posttranslational modification]
243231003177	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
243231003178	ATP binding site [chemical binding]; other site
243231003179	Mg2+ binding site [ion binding]; other site
243231003180	G-X-G motif; other site
243231003181	Response regulator receiver domain; Region: Response_reg; pfam00072
243231003182	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
243231003183	active site
243231003184	phosphorylation site [posttranslational modification]
243231003185	intermolecular recognition site; other site
243231003186	dimerization interface [polypeptide binding]; other site
243231003187	PAS fold; Region: PAS_4; pfam08448
243231003188	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
243231003189	metal binding site [ion binding]; metal-binding site
243231003190	active site
243231003191	I-site; other site
243231003192	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
243231003193	Response regulator receiver domain; Region: Response_reg; pfam00072
243231003194	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
243231003195	active site
243231003196	phosphorylation site [posttranslational modification]
243231003197	intermolecular recognition site; other site
243231003198	dimerization interface [polypeptide binding]; other site
243231003199	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459
243231003200	Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852
243231003201	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
243231003202	phosphorylation site [posttranslational modification]
243231003203	dimer interface [polypeptide binding]; other site
243231003204	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
243231003205	ATP binding site [chemical binding]; other site
243231003206	Mg2+ binding site [ion binding]; other site
243231003207	G-X-G motif; other site
243231003208	Response regulator receiver domain; Region: Response_reg; pfam00072
243231003209	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
243231003210	active site
243231003211	phosphorylation site [posttranslational modification]
243231003212	intermolecular recognition site; other site
243231003213	dimerization interface [polypeptide binding]; other site
243231003214	Transcriptional regulator containing PAS, AAA-type ATPase, and DNA-binding domains [Transcription / Signal transduction mechanisms]; Region: RocR; COG3829
243231003215	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
243231003216	Walker A motif; other site
243231003217	ATP binding site [chemical binding]; other site
243231003218	Walker B motif; other site
243231003219	arginine finger; other site
243231003220	Helix-turn-helix domains; Region: HTH; cl00088
243231003221	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
243231003222	dimerization interface [polypeptide binding]; other site
243231003223	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
243231003224	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
243231003225	dimer interface [polypeptide binding]; other site
243231003226	putative CheW interface [polypeptide binding]; other site
243231003227	Hemerythrin (Hr) is a non-heme diiron oxygen transport protein found in four marine invertebrate phyla including priapulida, brachiopoda, sipunculida, and annelida, as well as in protozoa. Myohemerythrin (Mhr), a hemerythrin homolog, is found in the...; Region: Hemerythrin; cl15774
243231003228	octamerization interface [polypeptide binding]; other site
243231003229	diferric-oxygen binding site [ion binding]; other site
243231003230	Uncharacterized conserved protein [Function unknown]; Region: COG2898
243231003231	PAS fold; Region: PAS_4; pfam08448
243231003232	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
243231003233	putative active site [active]
243231003234	heme pocket [chemical binding]; other site
243231003235	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
243231003236	bZIP transcription factor; Region: bZIP_1; cl02576
243231003237	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
243231003238	dimer interface [polypeptide binding]; other site
243231003239	phosphorylation site [posttranslational modification]
243231003240	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
243231003241	ATP binding site [chemical binding]; other site
243231003242	Mg2+ binding site [ion binding]; other site
243231003243	G-X-G motif; other site
243231003244	NADH pyrophosphatase; Reviewed; Region: nudC; PRK00241
243231003245	NADH pyrophosphatase-like rudimentary NUDIX domain; Region: NUDIX-like; pfam09296
243231003246	NADH pyrophosphatase zinc ribbon domain; Region: zf-NADH-PPase; pfam09297
243231003247	NADH pyrophosphatase, a member of the Nudix hydrolase superfamily, catalyzes the cleavage of NADH into reduced nicotinamide mononucleotide (NMNH) and AMP. Like other members of the Nudix family, it requires a divalent cation, such as Mg2+ or Mn2+, for...; Region: NADH_pyrophosphatase; cd03429
243231003248	putative NADH binding site [chemical binding]; other site
243231003249	putative active site [active]
243231003250	nudix motif; other site
243231003251	putative metal binding site [ion binding]; other site
243231003252	Domain of unknown function (DUF4149); Region: DUF4149; pfam13664
243231003253	Uncharacterized conserved protein (DUF2156); Region: DUF2156; cl12090
243231003254	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911
243231003255	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3012
243231003256	SEC-C motif; Region: SEC-C; pfam02810
243231003257	Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446
243231003258	sensory histidine kinase AtoS; Provisional; Region: PRK11360
243231003259	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080
243231003260	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
243231003261	ATP binding site [chemical binding]; other site
243231003262	Mg2+ binding site [ion binding]; other site
243231003263	G-X-G motif; other site
243231003264	PilZ domain; Region: PilZ; cl01260
243231003265	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
243231003266	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
243231003267	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
243231003268	putative active site [active]
243231003269	heme pocket [chemical binding]; other site
243231003270	SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain.  SirA (also known as UvrY,  and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291
243231003271	CPxP  motif; other site
243231003272	Sulphur transport; Region: Sulf_transp; cl01018
243231003273	putative inner membrane protein; Provisional; Region: PRK11099
243231003274	Uncharacterized protein family UPF0047; Region: UPF0047; cl00439
243231003275	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
243231003276	TPR motif; other site
243231003277	binding surface
243231003278	succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696
243231003279	ATP-grasp domain; Region: ATP-grasp_4; cl03087
243231003280	CoA-ligase; Region: Ligase_CoA; cl02894
243231003281	succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678
243231003282	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
243231003283	CoA-ligase; Region: Ligase_CoA; cl02894
243231003284	aspartate aminotransferase; Provisional; Region: PRK06836
243231003285	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
243231003286	pyridoxal 5'-phosphate binding site [chemical binding]; other site
243231003287	homodimer interface [polypeptide binding]; other site
243231003288	catalytic residue [active]
243231003289	type IV pilus modification protein PilV; Region: type_IV_pilV; TIGR02523
243231003290	Type II secretion system (T2SS), protein J; Region: T2SJ; pfam11612
243231003291	Neisseria PilC beta-propeller domain; Region: Neisseria_PilC; pfam05567
243231003292	Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401
243231003293	Predicted signal-transduction protein containing cAMP-binding and CBS domains [Signal transduction mechanisms]; Region: COG2905
243231003294	metal binding triad; other site
243231003295	Predicted symporter [General function prediction only]; Region: DhlC; COG4147
243231003296	Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u4; cd11480
243231003297	Na binding site [ion binding]; other site
243231003298	Protein of unknown function, DUF485; Region: DUF485; cl01231
243231003299	Predicted symporter [General function prediction only]; Region: DhlC; COG4147
243231003300	Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u4; cd11480
243231003301	Na binding site [ion binding]; other site
243231003302	Protein of unknown function, DUF485; Region: DUF485; cl01231
243231003303	Transcriptional regulator [Transcription]; Region: IclR; COG1414
243231003304	Helix-turn-helix domains; Region: HTH; cl00088
243231003305	Bacterial transcriptional regulator; Region: IclR; pfam01614
243231003306	Transcriptional regulator; Region: Transcrip_reg; cl00361
243231003307	Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination.  HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD includes...; Region: RuvC_resolvase; cd00529
243231003308	active site
243231003309	putative DNA-binding cleft [nucleotide binding]; other site
243231003310	dimer interface [polypeptide binding]; other site
243231003311	Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116
243231003312	RuvA N terminal domain; Region: RuvA_N; pfam01330
243231003313	RuvA, C-terminal domain; Region: RuvA_C; pfam07499
243231003314	Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080
243231003315	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
243231003316	Walker A motif; other site
243231003317	ATP binding site [chemical binding]; other site
243231003318	Walker B motif; other site
243231003319	arginine finger; other site
243231003320	Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491
243231003321	DnaA regulatory inactivator Hda; Region: DnaA_homol_Hda; TIGR03420
243231003322	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
243231003323	Walker A motif; other site
243231003324	ATP binding site [chemical binding]; other site
243231003325	Walker B motif; other site
243231003326	arginine finger; other site
243231003327	Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which  binds to Adenosine nucleotide; Region: AANH_like; cl00292
243231003328	Protein of unknown function (DUF2905); Region: DUF2905; pfam11146
243231003329	Membrane protease subunit, stomatin/prohibitin family [Amino acid    transport and metabolism]; Region: COG4260
243231003330	A subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin.  Many of these band 7 domain-containing proteins are lipid raft-associated.  Individual...; Region: Band_7_5; cd03408
243231003331	zinc-ribbon domain; Region: zf-ribbon_3; cl11198
243231003332	zinc-ribbon domain; Region: zf-ribbon_3; cl11198
243231003333	Poly(hydroxyalcanoate) granule associated protein (phasin); Region: Phasin; cl07863
243231003334	Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661
243231003335	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
243231003336	Uncharacterized Fe-S center protein [General function prediction only]; Region: COG2768
243231003337	Uncharacterized conserved protein [Function unknown]; Region: COG2006
243231003338	4Fe-4S binding domain; Region: Fer4; cl02805
243231003339	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
243231003340	active site
243231003341	phosphorylation site [posttranslational modification]
243231003342	intermolecular recognition site; other site
243231003343	dimerization interface [polypeptide binding]; other site
243231003344	Tim44-like domain; Region: Tim44; cl09208
243231003345	GH3 auxin-responsive promoter; Region: GH3; cl04006
243231003346	phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135
243231003347	PhoU domain; Region: PhoU; pfam01895
243231003348	PhoU domain; Region: PhoU; pfam01895
243231003349	phosphate ABC transporter ATP-binding protein; Provisional; Region: PRK14252
243231003350	Phosphate uptake is of fundamental importance in the cell physiology of bacteria because phosphate is required as a nutrient.  The Pst system of E. coli comprises four distinct subunits encoded by the pstS, pstA, pstB, and pstC genes.  The PstS protein...; Region: ABC_PstB_phosphate_transporter; cd03260
243231003351	Walker A/P-loop; other site
243231003352	ATP binding site [chemical binding]; other site
243231003353	Q-loop/lid; other site
243231003354	ABC transporter signature motif; other site
243231003355	Walker B; other site
243231003356	D-loop; other site
243231003357	H-loop/switch region; other site
243231003358	phosphate ABC transporter, permease protein PstA; Region: 3a0107s02c; TIGR00974
243231003359	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
243231003360	dimer interface [polypeptide binding]; other site
243231003361	conserved gate region; other site
243231003362	putative PBP binding loops; other site
243231003363	ABC-ATPase subunit interface; other site
243231003364	phosphate ABC transporter, permease protein PstC; Region: phosphate_pstC; TIGR02138
243231003365	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
243231003366	dimer interface [polypeptide binding]; other site
243231003367	conserved gate region; other site
243231003368	putative PBP binding loops; other site
243231003369	ABC-ATPase subunit interface; other site
243231003370	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
243231003371	Phosphate-starvation-inducible E; Region: PsiE; cl01264
243231003372	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054
243231003373	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
243231003374	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
243231003375	putative active site [active]
243231003376	heme pocket [chemical binding]; other site
243231003377	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
243231003378	dimer interface [polypeptide binding]; other site
243231003379	phosphorylation site [posttranslational modification]
243231003380	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
243231003381	ATP binding site [chemical binding]; other site
243231003382	Mg2+ binding site [ion binding]; other site
243231003383	G-X-G motif; other site
243231003384	phosphate regulon transcriptional regulatory protein PhoB; Region: PhoB; TIGR02154
243231003385	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
243231003386	active site
243231003387	phosphorylation site [posttranslational modification]
243231003388	intermolecular recognition site; other site
243231003389	dimerization interface [polypeptide binding]; other site
243231003390	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
243231003391	DNA binding site [nucleotide binding]
243231003392	AMP-binding domain protein; Validated; Region: PRK08315
243231003393	AMP-binding enzyme; Region: AMP-binding; cl15778
243231003394	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
243231003395	Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006
243231003396	Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321
243231003397	A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cl00279
243231003398	active site
243231003399	Saccharomyces cerevisiae (Sc) citrate synthase (CS)-like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) with oxaloacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). Some CS...; Region: ScCS-like; cd06103
243231003400	citrate (Si)-synthase, eukaryotic; Region: cit_synth_euk; TIGR01793
243231003401	dimer interface [polypeptide binding]; other site
243231003402	active site
243231003403	coenzyme A binding site [chemical binding]; other site
243231003404	citrylCoA binding site [chemical binding]; other site
243231003405	oxalacetate/citrate binding site [chemical binding]; other site
243231003406	catalytic triad [active]
243231003407	AMMECR1; Region: AMMECR1; cl00911
243231003408	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
243231003409	Uncharacterized ALDH (y4uC) with similarity to Tortula ruralis aldehyde dehydrogenase ALDH21A1; Region: ALDH_y4uC; cd07149
243231003410	NAD(P) binding site [chemical binding]; other site
243231003411	catalytic residues [active]
243231003412	Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413
243231003413	active site
243231003414	multimer interface [polypeptide binding]; other site
243231003415	ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK14463
243231003416	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
243231003417	FeS/SAM binding site; other site
243231003418	Phosphorylase superfamily; Region: PNP_UDP_1; cl00303
243231003419	Ribokinase-like subgroup C.  Found only in bacteria, this subgroup is part of the ribokinase/pfkB superfamily.  Its oligomerization state is unknown at this time; Region: ribokinase_group_C; cd01946
243231003420	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
243231003421	substrate binding site [chemical binding]; other site
243231003422	ATP binding site [chemical binding]; other site
243231003423	Tfp pilus assembly protein PilF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilF; COG3063
243231003424	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
243231003425	binding surface
243231003426	TPR motif; other site
243231003427	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
243231003428	binding surface
243231003429	TPR motif; other site
243231003430	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
243231003431	binding surface
243231003432	TPR motif; other site
243231003433	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761
243231003434	Domain of unknown function (DUF4115); Region: DUF4115; pfam13464
243231003435	GAF domain; Region: GAF; cl15785
243231003436	GAF domain; Region: GAF_2; pfam13185
243231003437	Response regulator receiver domain; Region: Response_reg; pfam00072
243231003438	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
243231003439	active site
243231003440	phosphorylation site [posttranslational modification]
243231003441	intermolecular recognition site; other site
243231003442	dimerization interface [polypeptide binding]; other site
243231003443	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
243231003444	Ligand Binding Site [chemical binding]; other site
243231003445	Response regulator receiver domain; Region: Response_reg; pfam00072
243231003446	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
243231003447	active site
243231003448	phosphorylation site [posttranslational modification]
243231003449	intermolecular recognition site; other site
243231003450	dimerization interface [polypeptide binding]; other site
243231003451	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
243231003452	dimer interface [polypeptide binding]; other site
243231003453	phosphorylation site [posttranslational modification]
243231003454	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
243231003455	ATP binding site [chemical binding]; other site
243231003456	Mg2+ binding site [ion binding]; other site
243231003457	G-X-G motif; other site
243231003458	Response regulator receiver domain; Region: Response_reg; pfam00072
243231003459	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
243231003460	active site
243231003461	phosphorylation site [posttranslational modification]
243231003462	intermolecular recognition site; other site
243231003463	dimerization interface [polypeptide binding]; other site
243231003464	Uncharacterized FAD-dependent dehydrogenases [General function prediction only]; Region: COG2509
243231003465	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
243231003466	3'-5' exoribonuclease YhaM; Provisional; Region: PRK13480
243231003467	YhaM_OBF_like: A subfamily of OB folds similar to that found in Bacillus subtilis YhaM and Staphylococcus aureus cmp-binding factor-1 (SaCBF1). Both these proteins are 3'-to-5'exoribonucleases. YhaM requires Mn2+ or Co2+ for activity and is inactive in...; Region: YhaM_OBF_like; cd04492
243231003468	generic binding surface II; other site
243231003469	generic binding surface I; other site
243231003470	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
243231003471	Zn2+ binding site [ion binding]; other site
243231003472	Mg2+ binding site [ion binding]; other site
243231003473	Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446
243231003474	bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579
243231003475	Flavoprotein; Region: Flavoprotein; cl08021
243231003476	DNA / pantothenate metabolism flavoprotein; Region: DFP; cl04410
243231003477	Zinc dependent phospholipase C/S1-P1 nuclease; Region: ZnPC_S1P1; cl16915
243231003478	Family 4 Uracil-DNA glycosylase (UDG), found exclusively in thermophilic organisms; Region: UDG_F4_TTUDGA_like; cd10030
243231003479	Fe-S cluster binding site [ion binding]; other site
243231003480	active site
243231003481	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
243231003482	CoenzymeA binding site [chemical binding]; other site
243231003483	subunit interaction site [polypeptide binding]; other site
243231003484	PHB binding site; other site
243231003485	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
243231003486	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
243231003487	active site
243231003488	phosphorylation site [posttranslational modification]
243231003489	intermolecular recognition site; other site
243231003490	dimerization interface [polypeptide binding]; other site
243231003491	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
243231003492	Walker A motif; other site
243231003493	ATP binding site [chemical binding]; other site
243231003494	Walker B motif; other site
243231003495	arginine finger; other site
243231003496	chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168
243231003497	Barmotin is a tight junction-associated protein expressed in rat epithelial cells which is thought to have an important regulatory role in tight junction barrier function.  Barmotin belongs to the SMC protein family. SMC proteins are large; Region: ABC_SMC_barmotin; cd03278
243231003498	Walker A/P-loop; other site
243231003499	ATP binding site [chemical binding]; other site
243231003500	SMC proteins Flexible Hinge Domain; Region: SMC_hinge; cl05797
243231003501	Barmotin is a tight junction-associated protein expressed in rat epithelial cells which is thought to have an important regulatory role in tight junction barrier function.  Barmotin belongs to the SMC protein family. SMC proteins are large; Region: ABC_SMC_barmotin; cd03278
243231003502	ABC transporter signature motif; other site
243231003503	Walker B; other site
243231003504	D-loop; other site
243231003505	H-loop/switch region; other site
243231003506	Roadblock/LC7 domain; Region: Robl_LC7; cl00886
243231003507	signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416
243231003508	SRP54-type protein, helical bundle domain; Region: SRP54_N; cl03758
243231003509	The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115
243231003510	P loop; other site
243231003511	GTP binding site [chemical binding]; other site
243231003512	Protein of unknown function (DUF904); Region: DUF904; cl11531
243231003513	Cell division protein ZapA; Region: ZapA; cl01146
243231003514	5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; cl00360
243231003515	phosphodiesterase; Provisional; Region: PRK12704
243231003516	ATP synthase B/B' CF(0); Region: ATP-synt_B; cl07975
243231003517	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
243231003518	Zn2+ binding site [ion binding]; other site
243231003519	Mg2+ binding site [ion binding]; other site
243231003520	Deinococcus radiodurans DR1281 and related proteins, metallophosphatase domain; Region: MPP_DR1281; cd07382
243231003521	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
243231003522	putative active site [active]
243231003523	metal binding site [ion binding]; metal-binding site
243231003524	homodimer binding site [polypeptide binding]; other site
243231003525	tyrosyl-tRNA synthetase; Validated; Region: PRK05912
243231003526	catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805
243231003527	active site
243231003528	HIGH motif; other site
243231003529	dimer interface [polypeptide binding]; other site
243231003530	KMSKS motif; other site
243231003531	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
243231003532	RNA binding surface [nucleotide binding]; other site
243231003533	Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840
243231003534	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
243231003535	dimerization interface [polypeptide binding]; other site
243231003536	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054
243231003537	methyl-accepting chemotaxis protein II; Provisional; Region: PRK15048
243231003538	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
243231003539	dimer interface [polypeptide binding]; other site
243231003540	putative CheW interface [polypeptide binding]; other site
243231003541	Signal transduction histidine kinase involved in nitrogen fixation and metabolism regulation [Signal transduction mechanisms]; Region: NtrY; COG5000
243231003542	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
243231003543	dimerization interface [polypeptide binding]; other site
243231003544	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
243231003545	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
243231003546	dimer interface [polypeptide binding]; other site
243231003547	putative CheW interface [polypeptide binding]; other site
243231003548	CheW, a small regulator protein, unique to the chemotaxis signalling in prokaryotes and archea. CheW interacts with the histidine kinase CheA, most likely with the related regulatory domain of CheA. CheW is proposed to form signalling arrays together...; Region: CheW; cd00732
243231003549	putative CheA interaction surface; other site
243231003550	CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705
243231003551	Methyltransferase, chemotaxis proteins; Region: MeTrc; smart00138
243231003552	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911
243231003553	CheD chemotactic sensory transduction; Region: CheD; cl00810
243231003554	chemotaxis-specific methylesterase; Provisional; Region: PRK00742
243231003555	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
243231003556	active site
243231003557	phosphorylation site [posttranslational modification]
243231003558	intermolecular recognition site; other site
243231003559	dimerization interface [polypeptide binding]; other site
243231003560	CheB methylesterase; Region: CheB_methylest; pfam01339
243231003561	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
243231003562	substrate binding pocket [chemical binding]; other site
243231003563	membrane-bound complex binding site; other site
243231003564	hinge residues; other site
243231003565	NMT1-like family; Region: NMT1_2; cl15260
243231003566	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
243231003567	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
243231003568	dimerization interface [polypeptide binding]; other site
243231003569	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
243231003570	dimer interface [polypeptide binding]; other site
243231003571	phosphorylation site [posttranslational modification]
243231003572	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
243231003573	ATP binding site [chemical binding]; other site
243231003574	Mg2+ binding site [ion binding]; other site
243231003575	G-X-G motif; other site
243231003576	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
243231003577	Predicted signal transduction protein containing EAL and modified HD-GYP domains [Signal transduction mechanisms]; Region: COG3434
243231003578	hopanoid biosynthesis associated radical SAM protein HpnJ; Region: HpnJ; TIGR03471
243231003579	B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293
243231003580	B12 binding site [chemical binding]; other site
243231003581	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
243231003582	FeS/SAM binding site; other site
243231003583	hopanoid biosynthesis associated protein HpnK and similar proteins; Region: YdjC_HpnK_like; cd10804
243231003584	putative active site [active]
243231003585	YdjC motif; other site
243231003586	Mg binding site [ion binding]; other site
243231003587	putative homodimer interface [polypeptide binding]; other site
243231003588	Small Multidrug Resistance protein; Region: Multi_Drug_Res; cl00910
243231003589	Hemolysin activation/secretion protein [Intracellular trafficking and secretion]; Region: FhaC; COG2831
243231003590	Surface antigen variable number repeat; Region: Surf_Ag_VNR; cl10520
243231003591	Surface antigen; Region: Bac_surface_Ag; cl03097
243231003592	haemagglutination activity domain; Region: Haemagg_act; cl05436
243231003593	NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976
243231003594	catalytic residues [active]
243231003595	asparaginyl-tRNA synthetase; Validated; Region: asnC; PRK03932
243231003596	EcAsnRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli asparaginyl-tRNA synthetase (AsnRS) and, in Arabidopsis thaliana and Saccharomyces cerevisiae mitochondrial (mt) AsnRS. This domain is a beta-barrel domain (OB...; Region: EcAsnRS_like_N; cd04318
243231003597	putative dimer interface [polypeptide binding]; other site
243231003598	putative anticodon binding site; other site
243231003599	Asx tRNA synthetase (AspRS/AsnRS) class II core domain.  Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776
243231003600	homodimer interface [polypeptide binding]; other site
243231003601	motif 1; other site
243231003602	motif 2; other site
243231003603	active site
243231003604	motif 3; other site
243231003605	Protein of unknown function (DUF503); Region: DUF503; cl00669
243231003606	Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777
243231003607	intracellular protease, PfpI family; Region: PfpI; TIGR01382
243231003608	A type 1 glutamine amidotransferase (GATase1)-like domain found in PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_like; cd03134
243231003609	proposed catalytic triad [active]
243231003610	conserved cys residue [active]
243231003611	nitrous-oxide reductase, Sec-dependent; Region: nitrous_NosZ_Gp; TIGR04246
243231003612	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
243231003613	Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404
243231003614	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
243231003615	This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE).  They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255
243231003616	Walker A/P-loop; other site
243231003617	ATP binding site [chemical binding]; other site
243231003618	Q-loop/lid; other site
243231003619	ABC transporter signature motif; other site
243231003620	Walker B; other site
243231003621	D-loop; other site
243231003622	H-loop/switch region; other site
243231003623	ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591
243231003624	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
243231003625	FtsX-like permease family; Region: FtsX; cl15850
243231003626	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
243231003627	FtsX-like permease family; Region: FtsX; cl15850
243231003628	Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080
243231003629	PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524
243231003630	PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; cl01586
243231003631	Pyruvate kinase (PK):  Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl09155
243231003632	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
243231003633	binding surface
243231003634	Tetratricopeptide repeat; Region: TPR_16; pfam13432
243231003635	TPR motif; other site
243231003636	TPR repeat; Region: TPR_11; pfam13414
243231003637	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
243231003638	binding surface
243231003639	TPR motif; other site
243231003640	TPR repeat; Region: TPR_11; pfam13414
243231003641	YtxH-like protein; Region: YtxH; cl02079
243231003642	SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379
243231003643	Protein of unknown function (DUF3047); Region: DUF3047; pfam11249
243231003644	Highly conserved protein containing a thioredoxin domain [Posttranslational modification, protein turnover, chaperones]; Region: COG1331
243231003645	TRX domain, SSP411 protein family; members of this family are highly conserved proteins present in eukaryotes, bacteria and archaea, about 600-800 amino acids in length, which contain a TRX domain with a redox active CXXC motif. The human/rat protein; Region: SSP411; cd02955
243231003646	catalytic residues [active]
243231003647	AGE domain; N-acyl-D-glucosamine 2-epimerase domain; Responsible for intermediate epimerization during biosynthesis of N-acetylneuraminic acid. Catalytic mechanism is believed to be via nucleotide elimination and readdition and is ATP modulated. AGE is...; Region: AGE; cl00183
243231003648	Uncharacterized membrane protein, putative virulence factor [General function prediction only]; Region: MviN; COG0728
243231003649	MatE; Region: MatE; cl10513
243231003650	The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445
243231003651	DNA binding site [nucleotide binding]
243231003652	active site
243231003653	nucleoside triphosphate pyrophosphohydrolase; Reviewed; Region: mazG; PRK09562
243231003654	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528
243231003655	homodimer interface [polypeptide binding]; other site
243231003656	metal binding site [ion binding]; metal-binding site
243231003657	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) C-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs'; Region: NTP-PPase_MazG_Cterm; cd11529
243231003658	homodimer interface [polypeptide binding]; other site
243231003659	active site
243231003660	putative chemical substrate binding site [chemical binding]; other site
243231003661	metal binding site [ion binding]; metal-binding site
243231003662	queuine tRNA-ribosyltransferase; Provisional; Region: tgt; cl00409
243231003663	Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343
243231003664	succinate dehydrogenase (or fumarate reductase) cytochrome b subunit, b558 family; Region: sdhC_b558_fam; TIGR02046
243231003665	Succinate:quinone oxidoreductase (SQR)-like Type B subfamily 2, transmembrane subunit; composed of proteins with similarity to the SQRs of Geobacter metallireducens and Corynebacterium glutamicum. SQR catalyzes the oxidation of succinate to fumarate...; Region: SQR_TypeB_2_TM; cd03498
243231003666	putative Iron-sulfur protein interface [polypeptide binding]; other site
243231003667	proximal heme binding site [chemical binding]; other site
243231003668	distal heme binding site [chemical binding]; other site
243231003669	putative dimer interface [polypeptide binding]; other site
243231003670	succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK07573
243231003671	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
243231003672	Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910
243231003673	succinate dehydrogenase/fumarate reductase iron-sulfur subunit; Validated; Region: PRK07570
243231003674	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cl00159
243231003675	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
243231003676	CRISPR/Cas system-associated RAMP superfamily protein Cas6; Region: Cas6-I-III; cl11443
243231003677	FtsH Extracellular; Region: FtsH_ext; pfam06480
243231003678	ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241
243231003679	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
243231003680	Walker B motif; other site
243231003681	arginine finger; other site
243231003682	Peptidase family M41; Region: Peptidase_M41; pfam01434
243231003683	4-alpha-glucanotransferase; Region: Glyco_hydro_77; cl00711
243231003684	OAH/OAS sulfhydrylase; Region: OAH_OAS_sulfhy; TIGR01326
243231003685	CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614
243231003686	homodimer interface [polypeptide binding]; other site
243231003687	substrate-cofactor binding pocket; other site
243231003688	pyridoxal 5'-phosphate binding site [chemical binding]; other site
243231003689	catalytic residue [active]
243231003690	Protein of unknown function, DUF479; Region: DUF479; cl01203
243231003691	Adenosine specific kinase; Region: Adenosine_kin; cl00796
243231003692	Transcription elongation factor Spt4; Region: Spt4; cl12033
243231003693	Rhomboid family; Region: Rhomboid; cl11446
243231003694	Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692
243231003695	Peptidase family M48; Region: Peptidase_M48; cl12018
243231003696	tRNA 2-selenouridine synthase; Provisional; Region: PRK11784
243231003697	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125
243231003698	active site residue [active]
243231003699	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
243231003700	active site
243231003701	PilZ domain; Region: PilZ; cl01260
243231003702	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl09108
243231003703	active site
243231003704	intersubunit interface [polypeptide binding]; other site
243231003705	zinc binding site [ion binding]; other site
243231003706	Na+ binding site [ion binding]; other site
243231003707	LysE type translocator; Region: LysE; cl00565
243231003708	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076
243231003709	TIGR03987 family protein; Region: TIGR03987
243231003710	SpoU rRNA Methylase family; Region: SpoU_methylase; cl00362
243231003711	D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK13581
243231003712	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
243231003713	C-terminal ACT (regulatory) domain of D-3-phosphoglycerate dehydrogenase (3PGDH); Region: ACT_3PGDH-xct; cd04902
243231003714	putative L-serine binding site [chemical binding]; other site
243231003715	Staphylococcal nuclease homologues; Region: SNc; smart00318
243231003716	Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cd00175
243231003717	Catalytic site; other site
243231003718	30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06676
243231003719	S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec1_hs1; cd05687
243231003720	RNA binding site [nucleotide binding]; other site
243231003721	S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec2_hs2; cd04465
243231003722	RNA binding site [nucleotide binding]; other site
243231003723	S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists of...; Region: S1_RPS1_repeat_ec3; cd05688
243231003724	RNA binding site [nucleotide binding]; other site
243231003725	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
243231003726	RNA binding site [nucleotide binding]; other site
243231003727	transcription elongation factor GreB; Reviewed; Region: greB; PRK01885
243231003728	Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449
243231003729	Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272
243231003730	Mannose-1-phosphate guanylyltransferase [Cell envelope biogenesis, outer membrane]; Region: {ManC}; COG0836
243231003731	GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509
243231003732	Substrate binding site; other site
243231003733	Cupin domain; Region: Cupin_2; cl09118
243231003734	potassium/proton antiporter; Reviewed; Region: PRK05326
243231003735	Anion permease ArsB/NhaD.  These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life.  A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl15357
243231003736	Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482
243231003737	putative cation:proton antiport protein; Provisional; Region: PRK10669
243231003738	K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569
243231003739	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
243231003740	Anion permease ArsB/NhaD.  These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life.  A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl15357
243231003741	NADPH-dependent FMN reductase; Region: FMN_red; cl00438
243231003742	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076
243231003743	Iron-sulphur cluster biosynthesis; Region: Fe-S_biosyn; cl00400
243231003744	Predicted membrane protein [Function unknown]; Region: COG2860
243231003745	UPF0126 domain; Region: UPF0126; pfam03458
243231003746	UPF0126 domain; Region: UPF0126; pfam03458
243231003747	Protein of unknown function (DUF4197); Region: DUF4197; pfam13852
243231003748	Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446
243231003749	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cl00083
243231003750	Protein of unknown function (DUF2950); Region: DUF2950; pfam11453
243231003751	Protein of unknown function (DUF3300); Region: DUF3300; pfam11737
243231003752	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
243231003753	S-adenosylmethionine binding site [chemical binding]; other site
243231003754	thiol reductant ABC exporter, CydD subunit; Region: CydD; TIGR02857
243231003755	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
243231003756	Walker A/P-loop; other site
243231003757	ATP binding site [chemical binding]; other site
243231003758	Q-loop/lid; other site
243231003759	ABC transporter signature motif; other site
243231003760	Walker B; other site
243231003761	D-loop; other site
243231003762	H-loop/switch region; other site
243231003763	cysteine/glutathione ABC transporter membrane/ATP-binding component; Reviewed; Region: PRK11160
243231003764	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
243231003765	Walker A/P-loop; other site
243231003766	ATP binding site [chemical binding]; other site
243231003767	Q-loop/lid; other site
243231003768	ABC transporter signature motif; other site
243231003769	Walker B; other site
243231003770	D-loop; other site
243231003771	H-loop/switch region; other site
243231003772	Domain of unknown function (DUF329); Region: DUF329; cl01144
243231003773	glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406
243231003774	catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808
243231003775	HIGH motif; other site
243231003776	catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808
243231003777	active site
243231003778	KMSKS motif; other site
243231003779	Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157
243231003780	Response regulator receiver domain; Region: Response_reg; pfam00072
243231003781	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
243231003782	active site
243231003783	phosphorylation site [posttranslational modification]
243231003784	intermolecular recognition site; other site
243231003785	dimerization interface [polypeptide binding]; other site
243231003786	Ammonium Transporter Family; Region: Ammonium_transp; cl03012
243231003787	Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123
243231003788	Histone deacetylase domain; Region: Hist_deacetyl; cl02986
243231003789	putative PEP-CTERM system TPR-repeat lipoprotein; Region: PEP_TPR_lipo; TIGR02917
243231003790	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
243231003791	binding surface
243231003792	TPR motif; other site
243231003793	potential protein location (hypothetical protein) that overlaps protein (hypothetical protein)
243231003794	potential protein location (hypothetical protein) that overlaps protein (hypothetical protein)
243231003795	ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127
243231003796	ABC (ATP-binding cassette) transport system involved in resistant to organic solvents; ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars, ions, peptides, and more complex...; Region: ABC_Org_Solvent_Resistant; cd03261
243231003797	Walker A/P-loop; other site
243231003798	ATP binding site [chemical binding]; other site
243231003799	Q-loop/lid; other site
243231003800	ABC transporter signature motif; other site
243231003801	Walker B; other site
243231003802	D-loop; other site
243231003803	H-loop/switch region; other site
243231003804	decaheme c-type cytochrome, DmsE family; Region: decahem_SO; TIGR03508
243231003805	Doubled CXXCH motif (Paired_CXXCH_1); Region: Paired_CXXCH_1; cl09905
243231003806	Doubled CXXCH motif (Paired_CXXCH_1); Region: Paired_CXXCH_1; cl09905
243231003807	Doubled CXXCH motif (Paired_CXXCH_1); Region: Paired_CXXCH_1; cl09905
243231003808	Type I periplasmic ligand-binding domain of uncharacterized ABC-type transport systems that are predicted to be involved in the uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_uncharacterized_transporter; cd06325
243231003809	zinc binding site [ion binding]; other site
243231003810	putative ligand binding site [chemical binding]; other site
243231003811	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
243231003812	active site
243231003813	phosphorylation site [posttranslational modification]
243231003814	intermolecular recognition site; other site
243231003815	Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841
243231003816	active site
243231003817	metal binding site [ion binding]; metal-binding site
243231003818	homotetramer interface [polypeptide binding]; other site
243231003819	Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023
243231003820	signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706
243231003821	tandem repeat interface [polypeptide binding]; other site
243231003822	oligomer interface [polypeptide binding]; other site
243231003823	active site residues [active]
243231003824	Archaeal-type gltB domain. This domain shares sequence similarity with a region of unknown function found in the large subunit of glutamate synthase, which is encoded by gltB and found in most bacteria and eukaryotes. It is predicted to be homologous to...; Region: arch_gltB; cd00981
243231003825	putative subunit interface; other site
243231003826	Glutamine amidotransferases class-II (Gn-AT)_GlxB-type.  GlxB is a glutamine amidotransferase-like protein of unknown function found in bacteria and archaea. GlxB has a structural fold similar to that of other class II glutamine amidotransferases...; Region: GlxB; cd01907
243231003827	Glutamine amidotransferase domain; Region: GATase_6; pfam13522
243231003828	putative active site [active]
243231003829	NAD(P)H-nitrite reductase [Energy production and conversion]; Region: NirB; COG1251
243231003830	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
243231003831	Fe-S-cluster-containing hydrogenase components 1 [Energy production and conversion]; Region: HybA; COG0437
243231003832	4Fe-4S binding domain; Region: Fer4; cl02805
243231003833	4Fe-4S dicluster domain; Region: Fer4_9; pfam13187
243231003834	4Fe-4S binding domain; Region: Fer4; cl02805
243231003835	ferredoxin; Provisional; Region: PRK06273
243231003836	Glutamate synthase (GltS) FMN-binding domain.  GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808
243231003837	Conserved region in glutamate synthase; Region: Glu_synthase; pfam01645
243231003838	active site
243231003839	FMN binding site [chemical binding]; other site
243231003840	substrate binding site [chemical binding]; other site
243231003841	3Fe-4S cluster binding site [ion binding]; other site
243231003842	PilZ domain; Region: PilZ; cl01260
243231003843	Domain of unknown function (DUF1858); Region: DUF1858; cl14817
243231003844	aspartate aminotransferase; Provisional; Region: PRK05764
243231003845	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
243231003846	pyridoxal 5'-phosphate binding site [chemical binding]; other site
243231003847	homodimer interface [polypeptide binding]; other site
243231003848	catalytic residue [active]
243231003849	phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168
243231003850	Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163
243231003851	active site
243231003852	(T/H)XGH motif; other site
243231003853	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
243231003854	S-adenosylmethionine binding site [chemical binding]; other site
243231003855	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl09108
243231003856	active site
243231003857	intersubunit interface [polypeptide binding]; other site
243231003858	zinc binding site [ion binding]; other site
243231003859	Na+ binding site [ion binding]; other site
243231003860	deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional; Region: PRK01286
243231003861	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076
243231003862	Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286
243231003863	YXWGXW repeat (2 copies); Region: YXWGXW; pfam12779
243231003864	Helix-turn-helix domain of transposase family ISL3; Region: HTH_Tnp_ISL3; pfam13542
243231003865	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
243231003866	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459
243231003867	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
243231003868	putative active site [active]
243231003869	heme pocket [chemical binding]; other site
243231003870	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
243231003871	dimer interface [polypeptide binding]; other site
243231003872	phosphorylation site [posttranslational modification]
243231003873	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
243231003874	ATP binding site [chemical binding]; other site
243231003875	Mg2+ binding site [ion binding]; other site
243231003876	G-X-G motif; other site
243231003877	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
243231003878	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
243231003879	active site
243231003880	phosphorylation site [posttranslational modification]
243231003881	intermolecular recognition site; other site
243231003882	dimerization interface [polypeptide binding]; other site
243231003883	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
243231003884	Walker A motif; other site
243231003885	ATP binding site [chemical binding]; other site
243231003886	Walker B motif; other site
243231003887	arginine finger; other site
243231003888	Helix-turn-helix domains; Region: HTH; cl00088
243231003889	Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540
243231003890	Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415
243231003891	Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540
243231003892	Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415
243231003893	Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540
243231003894	Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415
243231003895	Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415
243231003896	Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540
243231003897	Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415
243231003898	Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540
243231003899	Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415
243231003900	Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415
243231003901	Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415
243231003902	Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415
243231003903	Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415
243231003904	Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540
243231003905	Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415
243231003906	Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540
243231003907	Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415
243231003908	Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540
243231003909	Uncharacterized protein related to plant photosystem II stability/assembly factor [General function prediction only]; Region: COG4447
243231003910	PQQ-dependent catabolism-associated beta-propeller protein; Region: PQQ_ABC_repeats; TIGR03866
243231003911	40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276
243231003912	SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968
243231003913	Cu(I) binding site [ion binding]; other site
243231003914	SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968
243231003915	Cu(I) binding site [ion binding]; other site
243231003916	Cytochrome c; Region: Cytochrom_C; cl11414
243231003917	Periplasmic binding protein; Region: Peripla_BP_6; pfam13458
243231003918	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
243231003919	NosL; Region: NosL; cl01769
243231003920	FtsX-like permease family; Region: FtsX; cl15850
243231003921	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
243231003922	This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE).  They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255
243231003923	Walker A/P-loop; other site
243231003924	ATP binding site [chemical binding]; other site
243231003925	Q-loop/lid; other site
243231003926	ABC transporter signature motif; other site
243231003927	Walker B; other site
243231003928	D-loop; other site
243231003929	H-loop/switch region; other site
243231003930	CRS1 / YhbY (CRM) domain; Region: CRS1_YhbY; cl00663
243231003931	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cl00086
243231003932	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
243231003933	dimer interface [polypeptide binding]; other site
243231003934	phosphorylation site [posttranslational modification]
243231003935	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
243231003936	ATP binding site [chemical binding]; other site
243231003937	Mg2+ binding site [ion binding]; other site
243231003938	G-X-G motif; other site
243231003939	Response regulator receiver domain; Region: Response_reg; pfam00072
243231003940	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
243231003941	active site
243231003942	phosphorylation site [posttranslational modification]
243231003943	intermolecular recognition site; other site
243231003944	dimerization interface [polypeptide binding]; other site
243231003945	GTP-binding protein LepA; Provisional; Region: PRK05433
243231003946	LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890
243231003947	G1 box; other site
243231003948	putative GEF interaction site [polypeptide binding]; other site
243231003949	GTP/Mg2+ binding site [chemical binding]; other site
243231003950	Switch I region; other site
243231003951	G2 box; other site
243231003952	G3 box; other site
243231003953	Switch II region; other site
243231003954	G4 box; other site
243231003955	G5 box; other site
243231003956	lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699
243231003957	lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane.   LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709
243231003958	GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421
243231003959	signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227
243231003960	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
243231003961	Catalytic site [active]
243231003962	Transcriptional regulator [Transcription]; Region: LysR; COG0583
243231003963	Helix-turn-helix domains; Region: HTH; cl00088
243231003964	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
243231003965	dimerization interface [polypeptide binding]; other site
243231003966	Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383
243231003967	Uncharacterized conserved protein [Function unknown]; Region: COG5276
243231003968	LVIVD repeat; Region: LVIVD; pfam08309
243231003969	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
243231003970	active site
243231003971	aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856
243231003972	Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729
243231003973	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
243231003974	dihydroorotase; Validated; Region: pyrC; PRK09357
243231003975	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
243231003976	Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317
243231003977	active site
243231003978	carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564
243231003979	Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; cl03056
243231003980	Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744
243231003981	catalytic site [active]
243231003982	subunit interface [polypeptide binding]; other site
243231003983	Radical SAM superfamily; Region: Radical_SAM; pfam04055
243231003984	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
243231003985	FeS/SAM binding site; other site
243231003986	Protein of unknown function, DUF486; Region: DUF486; cl01236
243231003987	carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294
243231003988	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
243231003989	ATP-grasp domain; Region: ATP-grasp_4; cl03087
243231003990	Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787
243231003991	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
243231003992	ATP-grasp domain; Region: ATP-grasp_4; cl03087
243231003993	Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424
243231003994	IMP binding site; other site
243231003995	dimer interface [polypeptide binding]; other site
243231003996	partial ornithine binding site; other site
243231003997	transcription elongation factor GreA; Reviewed; Region: greA; PRK00226
243231003998	Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449
243231003999	Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272
243231004000	Domain of unknown function (DUF1858); Region: DUF1858; cl14817
243231004001	Cobalt uptake substrate-specific transmembrane region; Region: CbiM; cl00397
243231004002	PDGLE domain; Region: PDGLE; cl07986
243231004003	Cobalt transport protein; Region: CbiQ; cl00463
243231004004	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
243231004005	Domain I of the ABC component of a cobalt transport family found in bacteria, archaea, and eukaryota.  The transition metal cobalt is an essential component of many enzymes and must be transported into cells in appropriate amounts when needed.  This ABC...; Region: ABC_cobalt_CbiO_domain1; cd03225
243231004006	Walker A/P-loop; other site
243231004007	ATP binding site [chemical binding]; other site
243231004008	Q-loop/lid; other site
243231004009	ABC transporter signature motif; other site
243231004010	Walker B; other site
243231004011	D-loop; other site
243231004012	H-loop/switch region; other site
243231004013	NosL; Region: NosL; cl01769
243231004014	PAS domain S-box; Region: sensory_box; TIGR00229
243231004015	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
243231004016	putative active site [active]
243231004017	heme pocket [chemical binding]; other site
243231004018	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459
243231004019	Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852
243231004020	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
243231004021	dimer interface [polypeptide binding]; other site
243231004022	phosphorylation site [posttranslational modification]
243231004023	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
243231004024	ATP binding site [chemical binding]; other site
243231004025	Mg2+ binding site [ion binding]; other site
243231004026	G-X-G motif; other site
243231004027	Response regulator receiver domain; Region: Response_reg; pfam00072
243231004028	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
243231004029	active site
243231004030	phosphorylation site [posttranslational modification]
243231004031	intermolecular recognition site; other site
243231004032	dimerization interface [polypeptide binding]; other site
243231004033	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
243231004034	Response regulator receiver domain; Region: Response_reg; pfam00072
243231004035	active site
243231004036	phosphorylation site [posttranslational modification]
243231004037	intermolecular recognition site; other site
243231004038	dimerization interface [polypeptide binding]; other site
243231004039	Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840
243231004040	Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840
243231004041	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
243231004042	dimer interface [polypeptide binding]; other site
243231004043	putative CheW interface [polypeptide binding]; other site
243231004044	Response regulator receiver domain; Region: Response_reg; pfam00072
243231004045	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
243231004046	active site
243231004047	phosphorylation site [posttranslational modification]
243231004048	intermolecular recognition site; other site
243231004049	dimerization interface [polypeptide binding]; other site
243231004050	Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643
243231004051	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088
243231004052	putative binding surface; other site
243231004053	active site
243231004054	Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895
243231004055	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
243231004056	ATP binding site [chemical binding]; other site
243231004057	Mg2+ binding site [ion binding]; other site
243231004058	G-X-G motif; other site
243231004059	CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731
243231004060	Response regulator receiver domain; Region: Response_reg; pfam00072
243231004061	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
243231004062	active site
243231004063	phosphorylation site [posttranslational modification]
243231004064	intermolecular recognition site; other site
243231004065	dimerization interface [polypeptide binding]; other site
243231004066	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
243231004067	putative active site [active]
243231004068	heme pocket [chemical binding]; other site
243231004069	Histidine kinase; Region: HisKA_3; pfam07730
243231004070	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
243231004071	ATP binding site [chemical binding]; other site
243231004072	Mg2+ binding site [ion binding]; other site
243231004073	G-X-G motif; other site
243231004074	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
243231004075	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
243231004076	active site
243231004077	phosphorylation site [posttranslational modification]
243231004078	intermolecular recognition site; other site
243231004079	dimerization interface [polypeptide binding]; other site
243231004080	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
243231004081	DNA binding residues [nucleotide binding]
243231004082	dimerization interface [polypeptide binding]; other site
243231004083	Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729
243231004084	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
243231004085	dimerization interface [polypeptide binding]; other site
243231004086	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
243231004087	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
243231004088	dimer interface [polypeptide binding]; other site
243231004089	putative CheW interface [polypeptide binding]; other site
243231004090	ABC-type amino acid transport/signal transduction systems, periplasmic component/domain [Amino acid transport and metabolism / Signal transduction mechanisms]; Region: HisJ; COG0834
243231004091	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl15306
243231004092	membrane-bound complex binding site; other site
243231004093	hinge residues; other site
243231004094	sensory histidine kinase AtoS; Provisional; Region: PRK11360
243231004095	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
243231004096	dimer interface [polypeptide binding]; other site
243231004097	phosphorylation site [posttranslational modification]
243231004098	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
243231004099	ATP binding site [chemical binding]; other site
243231004100	Mg2+ binding site [ion binding]; other site
243231004101	G-X-G motif; other site
243231004102	Response regulator receiver domain; Region: Response_reg; pfam00072
243231004103	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
243231004104	active site
243231004105	phosphorylation site [posttranslational modification]
243231004106	intermolecular recognition site; other site
243231004107	Transposase domain (DUF772); Region: DUF772; pfam05598
243231004108	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
243231004109	DDE superfamily endonuclease; Region: DDE_4; cl15789
243231004110	Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729
243231004111	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
243231004112	dimerization interface [polypeptide binding]; other site
243231004113	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
243231004114	dimer interface [polypeptide binding]; other site
243231004115	putative CheW interface [polypeptide binding]; other site
243231004116	CheW, a small regulator protein, unique to the chemotaxis signalling in prokaryotes and archea. CheW interacts with the histidine kinase CheA, most likely with the related regulatory domain of CheA. CheW is proposed to form signalling arrays together...; Region: CheW; cd00732
243231004117	putative CheA interaction surface; other site
243231004118	Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729
243231004119	methyl-accepting chemotaxis protein II; Provisional; Region: PRK15048
243231004120	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
243231004121	dimerization interface [polypeptide binding]; other site
243231004122	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
243231004123	dimer interface [polypeptide binding]; other site
243231004124	putative CheW interface [polypeptide binding]; other site
243231004125	CheW, a small regulator protein, unique to the chemotaxis signalling in prokaryotes and archea. CheW interacts with the histidine kinase CheA, most likely with the related regulatory domain of CheA. CheW is proposed to form signalling arrays together...; Region: CheW; cd00732
243231004126	putative CheA interaction surface; other site
243231004127	Protein of unknown function (DUF3365); Region: DUF3365; pfam11845
243231004128	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054
243231004129	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
243231004130	dimer interface [polypeptide binding]; other site
243231004131	phosphorylation site [posttranslational modification]
243231004132	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
243231004133	ATP binding site [chemical binding]; other site
243231004134	Mg2+ binding site [ion binding]; other site
243231004135	G-X-G motif; other site
243231004136	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
243231004137	active site
243231004138	phosphorylation site [posttranslational modification]
243231004139	intermolecular recognition site; other site
243231004140	dimerization interface [polypeptide binding]; other site
243231004141	Signal transduction histidine kinase involved in nitrogen fixation and metabolism regulation [Signal transduction mechanisms]; Region: NtrY; COG5000
243231004142	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
243231004143	dimerization interface [polypeptide binding]; other site
243231004144	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
243231004145	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
243231004146	dimer interface [polypeptide binding]; other site
243231004147	putative CheW interface [polypeptide binding]; other site
243231004148	MCP-signal associated domain; Region: MCPsignal_assoc; pfam13682
243231004149	methyl-accepting chemotaxis protein I; Provisional; Region: PRK15041
243231004150	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
243231004151	dimerization interface [polypeptide binding]; other site
243231004152	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
243231004153	dimer interface [polypeptide binding]; other site
243231004154	putative CheW interface [polypeptide binding]; other site
243231004155	glutamate dehydrogenase; Provisional; Region: PRK09414
243231004156	Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812
243231004157	NAD(P) binding domain of glutamate dehydrogenase, subgroup 2; Region: NAD_bind_2_Glu_DH; cd05313
243231004158	NAD(P) binding site [chemical binding]; other site
243231004159	DNA polymerase alpha chain like domain; Region: POLIIIAc; smart00481
243231004160	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
243231004161	active site
243231004162	ATP binding site [chemical binding]; other site
243231004163	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
243231004164	substrate binding site [chemical binding]; other site
243231004165	nonheme-containing ferritins; Region: Nonheme_Ferritin; cd01055
243231004166	Ferritin-like domain; Region: Ferritin; pfam00210
243231004167	ferroxidase diiron center [ion binding]; other site
243231004168	Protein of unknown function (DUF1450); Region: DUF1450; cl11488
243231004169	magnesium chelatase subunit H; Provisional; Region: bchH; PRK13405
243231004170	pyridine nucleotide-disulfide oxidoreductase family protein; Region: Nterm_to_SelD; TIGR03169
243231004171	glucose-6-phosphate isomerase; Provisional; Region: pgi; PRK14096
243231004172	Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015
243231004173	active site
243231004174	dimer interface [polypeptide binding]; other site
243231004175	Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016
243231004176	dimer interface [polypeptide binding]; other site
243231004177	active site
243231004178	radical SAM/Cys-rich domain protein; Region: rSAM_SeCys; TIGR04167
243231004179	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
243231004180	FeS/SAM binding site; other site
243231004181	Protein of unknown function (DUF3641); Region: DUF3641; pfam12345
243231004182	Carboxymuconolactone decarboxylase family; Region: CMD; cl00460
243231004183	SNARE associated Golgi protein; Region: SNARE_assoc; cl00429
243231004184	mercuric reductase; Validated; Region: PRK06370
243231004185	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
243231004186	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
243231004187	Response regulator receiver domain; Region: Response_reg; pfam00072
243231004188	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
243231004189	active site
243231004190	phosphorylation site [posttranslational modification]
243231004191	intermolecular recognition site; other site
243231004192	dimerization interface [polypeptide binding]; other site
243231004193	GAF domain; Region: GAF_2; pfam13185
243231004194	GAF domain; Region: GAF; cl15785
243231004195	Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142
243231004196	Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685
243231004197	substrate binding pocket [chemical binding]; other site
243231004198	chain length determination region; other site
243231004199	substrate-Mg2+ binding site; other site
243231004200	catalytic residues [active]
243231004201	aspartate-rich region 1; other site
243231004202	active site lid residues [active]
243231004203	aspartate-rich region 2; other site
243231004204	Domain of unknown function (DUF4118); Region: DUF4118; pfam13493
243231004205	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920
243231004206	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
243231004207	dimer interface [polypeptide binding]; other site
243231004208	phosphorylation site [posttranslational modification]
243231004209	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
243231004210	ATP binding site [chemical binding]; other site
243231004211	Mg2+ binding site [ion binding]; other site
243231004212	G-X-G motif; other site
243231004213	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
243231004214	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
243231004215	active site
243231004216	phosphorylation site [posttranslational modification]
243231004217	intermolecular recognition site; other site
243231004218	dimerization interface [polypeptide binding]; other site
243231004219	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
243231004220	Walker A motif; other site
243231004221	ATP binding site [chemical binding]; other site
243231004222	Walker B motif; other site
243231004223	arginine finger; other site
243231004224	Helix-turn-helix domains; Region: HTH; cl00088
243231004225	TlpA-like family; composed of  TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966
243231004226	catalytic residues [active]
243231004227	Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788
243231004228	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
243231004229	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632
243231004230	active site
243231004231	RRM (RNA recognition motif), also known as RBD (RNA binding domain) or RNP (ribonucleoprotein domain), is a highly abundant domain in eukaryotes found in proteins involved in post-transcriptional gene expression processes including mRNA and rRNA...; Region: RRM; cd00590
243231004232	RNA/DNA binding site [nucleotide binding]; other site
243231004233	RRM dimerization site [polypeptide binding]; other site
243231004234	ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917
243231004235	RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488
243231004236	generic binding surface II; other site
243231004237	ssDNA binding site; other site
243231004238	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
243231004239	ATP binding site [chemical binding]; other site
243231004240	putative Mg++ binding site [ion binding]; other site
243231004241	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
243231004242	nucleotide binding region [chemical binding]; other site
243231004243	ATP-binding site [chemical binding]; other site
243231004244	Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; cl14105
243231004245	Homocysteine S-methyltransferase; Region: S-methyl_trans; pfam02574
243231004246	Protein of unknown function (DUF1255); Region: DUF1255; cl01202
243231004247	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
243231004248	active site
243231004249	HIGH motif; other site
243231004250	nucleotide binding site [chemical binding]; other site
243231004251	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
243231004252	active site
243231004253	KMSKS motif; other site
243231004254	Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538
243231004255	NHLM bacteriocin system secretion protein; Region: NHLM_micro_HlyD; TIGR03794
243231004256	Membrane Fusion Protein cluster 2 (function with RND porters); Region: 8a0102; TIGR00999
243231004257	Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404
243231004258	Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696
243231004259	Cytochrome c554 and c-prime; Region: Cytochrome_C554; pfam13435
243231004260	Integral membrane protein TerC family; Region: TerC; cl10468
243231004261	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
243231004262	metal-binding site [ion binding]
243231004263	Predicted membrane protein (DUF2318); Region: DUF2318; pfam10080
243231004264	ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591
243231004265	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
243231004266	FtsX-like permease family; Region: FtsX; cl15850
243231004267	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
243231004268	This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE).  They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255
243231004269	Walker A/P-loop; other site
243231004270	ATP binding site [chemical binding]; other site
243231004271	Q-loop/lid; other site
243231004272	ABC transporter signature motif; other site
243231004273	Walker B; other site
243231004274	D-loop; other site
243231004275	H-loop/switch region; other site
243231004276	DNA-binding transcriptional activator XapR; Provisional; Region: PRK09986
243231004277	Helix-turn-helix domains; Region: HTH; cl00088
243231004278	The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414
243231004279	dimerization interface [polypeptide binding]; other site
243231004280	substrate binding pocket [chemical binding]; other site
243231004281	Isochorismatase family; Region: Isochorismatase; pfam00857
243231004282	YcaC related amidohydrolases; E.coli YcaC is an homooctameric hydrolase with unknown specificity. Despite its weak sequence similarity, it is structurally related to other amidohydrolases and shares conserved active site residues with them; Region: YcaC_related; cd01012
243231004283	catalytic triad [active]
243231004284	dimer interface [polypeptide binding]; other site
243231004285	conserved cis-peptide bond; other site
243231004286	Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574
243231004287	YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300
243231004288	active site
243231004289	Predicted transcriptional regulator [Transcription]; Region: COG1959
243231004290	Helix-turn-helix domains; Region: HTH; cl00088
243231004291	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
243231004292	Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531
243231004293	ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555
243231004294	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
243231004295	dimer interface [polypeptide binding]; other site
243231004296	conserved gate region; other site
243231004297	putative PBP binding loops; other site
243231004298	ABC-ATPase subunit interface; other site
243231004299	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
243231004300	dimer interface [polypeptide binding]; other site
243231004301	conserved gate region; other site
243231004302	putative PBP binding loops; other site
243231004303	ABC-ATPase subunit interface; other site
243231004304	ABC-type sulfate/molybdate transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: CysA; COG1118
243231004305	Part of the ABC transporter complex cysAWTP involved in sulfate import.  Responsible for energy coupling to the transport system.  The complex is composed of two ATP-binding proteins (cysA), two transmembrane proteins (cysT and cysW), and a...; Region: ABC_CysA_sulfate_importer; cd03296
243231004306	Walker A/P-loop; other site
243231004307	ATP binding site [chemical binding]; other site
243231004308	Q-loop/lid; other site
243231004309	ABC transporter signature motif; other site
243231004310	Walker B; other site
243231004311	D-loop; other site
243231004312	H-loop/switch region; other site
243231004313	TOBE-like domain; Region: TOBE_3; pfam12857
243231004314	molybdopterin biosynthesis protein MoeB; Provisional; Region: PRK05690
243231004315	ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757
243231004316	ATP binding site [chemical binding]; other site
243231004317	substrate interface [chemical binding]; other site
243231004318	Dissimilatory sulfite reductase (desulfoviridin), alpha and beta subunits [Energy production and conversion]; Region: DsrA; COG2221
243231004319	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
243231004320	4Fe-4S binding domain; Region: Fer4; cl02805
243231004321	SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain.  SirA (also known as UvrY,  and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291
243231004322	CPxP  motif; other site
243231004323	Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; cl09153
243231004324	Plasmid stabilisation system protein; Region: Plasmid_stabil; cl11422
243231004325	putative transposase OrfB; Reviewed; Region: PHA02517
243231004326	HTH-like domain; Region: HTH_21; pfam13276
243231004327	Integrase core domain; Region: rve; cl01316
243231004328	Integrase core domain; Region: rve_3; cl15866
243231004329	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in mouse RS21-C6 protein and its homologs; Region: NTP-PPase_RS21-C6_like; cd11537
243231004330	homodimer interface [polypeptide binding]; other site
243231004331	chemical substrate binding site [chemical binding]; other site
243231004332	oligomer interface [polypeptide binding]; other site
243231004333	metal binding site [ion binding]; metal-binding site
243231004334	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
243231004335	Uncharacterized conserved protein (DUF2075); Region: DUF2075; pfam09848
243231004336	Uncharacterized conserved protein [Function unknown]; Region: COG3410
243231004337	Predicted transcriptional regulator [Transcription]; Region: COG2932
243231004338	Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529
243231004339	Catalytic site [active]
243231004340	N-terminal putative catalytic domain of uncharacterized prokaryotic and archeal HKD family nucleases fused to a DEAD/DEAH box helicase domain; Region: PLDc_N_DEXD_b1; cd09203
243231004341	PLD-like domain; Region: PLDc_2; pfam13091
243231004342	putative homodimer interface [polypeptide binding]; other site
243231004343	putative active site [active]
243231004344	catalytic site [active]
243231004345	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
243231004346	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
243231004347	nucleotide binding region [chemical binding]; other site
243231004348	ATP-binding site [chemical binding]; other site
243231004349	Domain of unknown function (DUF3427); Region: DUF3427; pfam11907
243231004350	SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2; cl00195
243231004351	Piwi_piwi-like_ProArk: PIWI domain, Piwi-like subfamily found in Archaea and Bacteria. RNA silencing refers to a group of related gene-silencing mechanisms mediated by short RNA molecules, including siRNAs, miRNAs, and heterochromatin-related guide RNAs; Region: Piwi_piwi-like_ProArk; cd04659
243231004352	5' RNA guide strand anchoring site; other site
243231004353	active site
243231004354	Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078
243231004355	RT_Bac_retron_II: Reverse transcriptases (RTs) in bacterial retrotransposons or retrons. The polymerase reaction of this enzyme leads to the production of a unique RNA-DNA complex called msDNA (multicopy single-stranded (ss)DNA) in which a small ssDNA...; Region: RT_Bac_retron_II; cd03487
243231004356	putative active site [active]
243231004357	putative NTP binding site [chemical binding]; other site
243231004358	putative nucleic acid binding site [nucleotide binding]; other site
243231004359	Predicted restriction endonuclease [Defense mechanisms]; Region: COG3440
243231004360	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
243231004361	active site
243231004362	Restriction endonuclease; Region: Mrr_cat; cl00516
243231004363	Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396
243231004364	Domain of unknown function (DUF4095); Region: DUF4095; pfam13338
243231004365	Nucleotidyl transferase of unknown function (DUF1814); Region: DUF1814; cl00973
243231004366	Domain of unknown function, appears to be related to a diverse group of endonucleases; Region: Endonuclease_DUF559; cd01038
243231004367	putative active site [active]
243231004368	Predicted oxidoreductases of the aldo/keto reductase family [General function prediction only]; Region: COG1453
243231004369	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
243231004370	active site
243231004371	catalytic tetrad [active]
243231004372	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
243231004373	Old yellow enzyme (OYE) YqjM-like FMN binding domain. YqjM is involved in the oxidative stress response of Bacillus subtilis.  Like the other OYE members, each monomer of YqjM contains FMN as a non-covalently bound cofactor and uses NADPH as a reducing...; Region: OYE_YqiM_FMN; cd02932
243231004374	active site
243231004375	FMN binding site [chemical binding]; other site
243231004376	substrate binding site [chemical binding]; other site
243231004377	homotetramer interface [polypeptide binding]; other site
243231004378	catalytic residue [active]
243231004379	3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084
243231004380	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
243231004381	Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729
243231004382	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
243231004383	dimerization interface [polypeptide binding]; other site
243231004384	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
243231004385	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
243231004386	dimer interface [polypeptide binding]; other site
243231004387	putative CheW interface [polypeptide binding]; other site
243231004388	Uncharacterized ArCR, COG2043; Region: DUF169; cl00894
243231004389	3-hydroxybutyryl-CoA dehydratase; Validated; Region: PRK05809
243231004390	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
243231004391	substrate binding site [chemical binding]; other site
243231004392	oxyanion hole (OAH) forming residues; other site
243231004393	trimer interface [polypeptide binding]; other site
243231004394	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009
243231004395	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153
243231004396	metal binding site 2 [ion binding]; metal-binding site
243231004397	putative DNA binding helix; other site
243231004398	metal binding site 1 [ion binding]; metal-binding site
243231004399	dimer interface [polypeptide binding]; other site
243231004400	structural Zn2+ binding site [ion binding]; other site
243231004401	Fe2+ transport system protein B [Inorganic ion transport and metabolism]; Region: FeoB; COG0370
243231004402	Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879
243231004403	G1 box; other site
243231004404	GTP/Mg2+ binding site [chemical binding]; other site
243231004405	Switch I region; other site
243231004406	G2 box; other site
243231004407	G3 box; other site
243231004408	Switch II region; other site
243231004409	G4 box; other site
243231004410	G5 box; other site
243231004411	Nucleoside recognition; Region: Gate; cl00486
243231004412	Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664
243231004413	Nucleoside recognition; Region: Gate; cl00486
243231004414	Mn-dependent transcriptional regulator [Transcription]; Region: TroR; COG1321
243231004415	Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742
243231004416	FeoA domain; Region: FeoA; cl00838
243231004417	DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127
243231004418	active site
243231004419	catalytic site [active]
243231004420	substrate binding site [chemical binding]; other site
243231004421	helicase Cas3; Provisional; Region: PRK09694
243231004422	CRISPR/Cas system-associated protein Cas3''; Region: Cas3''_I; cd09641
243231004423	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
243231004424	CRISPR/Cas system-associated protein Cse1; Region: Cse1_I-E; cd09669
243231004425	CRISPR/Cas system-associated protein Cse2; Region: Cse2_I-E; cd09670
243231004426	CRISPR/Cas system-associated RAMP superfamily protein Cas7; Region: Cas7_I-E; cl09608
243231004427	CRISPR-associated protein (Cas_Cas5); Region: Cas_Cas5d; pfam09704
243231004428	CRISPR/Cas system-associated RAMP superfamily protein Cas5; Region: Cas5_I-E; cd09756
243231004429	CRISPR/Cas system-associated RAMP superfamily protein Cas6e; Region: Cas6_I-E; cd09727
243231004430	mobile mystery protein A; Region: mob_myst_A; TIGR02612
243231004431	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761
243231004432	mobile mystery protein B; Region: mob_myst_B; TIGR02613
243231004433	Fic/DOC family; Region: Fic; cl00960
243231004434	CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-E; cd09719
243231004435	CRISPR/Cas system-associated protein Cas2; Region: Cas2_I-E; cd09648
243231004436	Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; cl11412
243231004437	Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063
243231004438	Interdomain contacts; other site
243231004439	Cytokine receptor motif; other site
243231004440	Periplasmic binding domain of ATP-binding cassette transporter-like systems that belong to the type I periplasmic binding fold protein superfamily; Region: PBP1_ABC_transporter_LIVBP_like; cd06268
243231004441	ligand binding site [chemical binding]; other site
243231004442	SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968
243231004443	Cu(I) binding site [ion binding]; other site
243231004444	magnesium Mg(2+) and cobalt Co(2+) transport protein (corA); Region: corA; TIGR00383
243231004445	magnesium/nickel/cobalt transporter CorA; Provisional; Region: PRK11085; cl00459
243231004446	DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673
243231004447	Bacterial DNA polymerase III alpha subunit; Region: DNA_pol3_alpha; pfam07733
243231004448	DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485
243231004449	generic binding surface II; other site
243231004450	generic binding surface I; other site
243231004451	Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl15772
243231004452	acetyl-CoA carboxylase carboxyltransferase alpha subunit; Provisional; Region: accA; CHL00198
243231004453	16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187
243231004454	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
243231004455	RNA binding surface [nucleotide binding]; other site
243231004456	Pseudouridine synthases, RsuA subfamily; Region: PseudoU_synth_RsuA_like; cd02870
243231004457	active site
243231004458	Fe-S oxidoreductases [Energy production and conversion]; Region: COG0731
243231004459	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
243231004460	FeS/SAM binding site; other site
243231004461	Rdx family; Region: Rdx; cl01407
243231004462	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
243231004463	MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037
243231004464	NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822
243231004465	Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664
243231004466	trimerization site [polypeptide binding]; other site
243231004467	active site
243231004468	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761
243231004469	Arsenite efflux pump ACR3 and related permeases [Inorganic ion transport and metabolism]; Region: ACR3; COG0798
243231004470	Membrane transport protein; Region: Mem_trans; cl09117
243231004471	Domain of unknown function DUF302; Region: DUF302; cl01364
243231004472	PAS fold; Region: PAS_4; pfam08448
243231004473	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
243231004474	putative active site [active]
243231004475	heme pocket [chemical binding]; other site
243231004476	PAS domain S-box; Region: sensory_box; TIGR00229
243231004477	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
243231004478	putative active site [active]
243231004479	heme pocket [chemical binding]; other site
243231004480	Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852
243231004481	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
243231004482	putative active site [active]
243231004483	heme pocket [chemical binding]; other site
243231004484	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
243231004485	dimer interface [polypeptide binding]; other site
243231004486	phosphorylation site [posttranslational modification]
243231004487	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
243231004488	ATP binding site [chemical binding]; other site
243231004489	Mg2+ binding site [ion binding]; other site
243231004490	G-X-G motif; other site
243231004491	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
243231004492	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
243231004493	active site
243231004494	phosphorylation site [posttranslational modification]
243231004495	intermolecular recognition site; other site
243231004496	dimerization interface [polypeptide binding]; other site
243231004497	Response regulator receiver domain; Region: Response_reg; pfam00072
243231004498	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
243231004499	active site
243231004500	phosphorylation site [posttranslational modification]
243231004501	intermolecular recognition site; other site
243231004502	dimerization interface [polypeptide binding]; other site
243231004503	Heterodisulfide reductase, subunit C [Energy production and conversion]; Region: HdrC; COG1150
243231004504	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
243231004505	active site
243231004506	phosphorylation site [posttranslational modification]
243231004507	intermolecular recognition site; other site
243231004508	dimerization interface [polypeptide binding]; other site
243231004509	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
243231004510	non-specific DNA binding site [nucleotide binding]; other site
243231004511	salt bridge; other site
243231004512	sequence-specific DNA binding site [nucleotide binding]; other site
243231004513	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911
243231004514	DNA repair exonuclease [DNA replication, recombination, and repair]; Region: SbcD; COG0420
243231004515	Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840
243231004516	active site
243231004517	metal binding site [ion binding]; metal-binding site
243231004518	DNA binding site [nucleotide binding]
243231004519	ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: SbcC; COG0419
243231004520	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
243231004521	AAA domain; Region: AAA_27; pfam13514
243231004522	Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893
243231004523	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
243231004524	ABC transporter signature motif; other site
243231004525	Walker B; other site
243231004526	D-loop; other site
243231004527	H-loop/switch region; other site
243231004528	Protein Kinase C Interacting protein related (PKCI): PKCI and related proteins belong to the ubiquitous HIT family of hydrolases that act on alpha-phosphates of ribonucleotides. The members of this subgroup have a conserved HxHxHxx motif (x is a...; Region: PKCI_related; cd01276
243231004529	nucleotide binding site/active site [active]
243231004530	HIT family signature motif; other site
243231004531	catalytic residue [active]
243231004532	Domain of unknown function (DUF4124); Region: DUF4124; pfam13511
243231004533	Prolipoprotein diacylglyceryl transferase; Region: LGT; cl00478
243231004534	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075
243231004535	Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581
243231004536	Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043
243231004537	anti sigma factor interaction site; other site
243231004538	regulatory phosphorylation site [posttranslational modification]; other site
243231004539	Predicted symporter [General function prediction only]; Region: DhlC; COG4147
243231004540	Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456
243231004541	Na binding site [ion binding]; other site
243231004542	GAF domain; Region: GAF; cl15785
243231004543	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2187
243231004544	Gluconate kinase (GntK) catalyzes the phosphoryl transfer from ATP to gluconate. The resulting product gluconate-6-phoshate is an important precursor of gluconate metabolism. GntK acts as a dimmer composed of two identical subunits; Region: GntK; cd02021
243231004545	AAA domain; Region: AAA_33; pfam13671
243231004546	ATP-binding site [chemical binding]; other site
243231004547	Gluconate-6-phosphate binding site [chemical binding]; other site
243231004548	TPR repeat; Region: TPR_11; pfam13414
243231004549	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
243231004550	binding surface
243231004551	TPR motif; other site
243231004552	TPR repeat; Region: TPR_11; pfam13414
243231004553	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
243231004554	TPR motif; other site
243231004555	binding surface
243231004556	TPR repeat; Region: TPR_11; pfam13414
243231004557	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
243231004558	binding surface
243231004559	TPR motif; other site
243231004560	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
243231004561	binding surface
243231004562	TPR motif; other site
243231004563	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
243231004564	binding surface
243231004565	TPR motif; other site
243231004566	TPR repeat; Region: TPR_11; pfam13414
243231004567	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
243231004568	binding surface
243231004569	TPR motif; other site
243231004570	TPR repeat; Region: TPR_11; pfam13414
243231004571	The substrate-binding component of the oligopeptide-binding protein, AppA, from Bacillus subtilis contains the type 2 periplasmic-binding fold; Region: PBP2_AppA_like; cd08514
243231004572	peptide binding site [polypeptide binding]; other site
243231004573	Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496
243231004574	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
243231004575	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
243231004576	dimer interface [polypeptide binding]; other site
243231004577	conserved gate region; other site
243231004578	putative PBP binding loops; other site
243231004579	ABC-ATPase subunit interface; other site
243231004580	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173
243231004581	N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911
243231004582	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
243231004583	dimer interface [polypeptide binding]; other site
243231004584	conserved gate region; other site
243231004585	putative PBP binding loops; other site
243231004586	ABC-ATPase subunit interface; other site
243231004587	Peptidase family M48; Region: Peptidase_M48; cl12018
243231004588	Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG2607
243231004589	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
243231004590	Walker A motif; other site
243231004591	ATP binding site [chemical binding]; other site
243231004592	Walker B motif; other site
243231004593	arginine finger; other site
243231004594	CO dehydrogenase/acetyl-CoA synthase gamma subunit (corrinoid Fe-S protein) [Energy production and conversion]; Region: CdhE; COG1456
243231004595	RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409
243231004596	4Fe-4S dicluster domain; Region: Fer4_7; pfam12838
243231004597	carbonic anhydrase; Provisional; Region: PRK15219
243231004598	Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeC; cd03378
243231004599	active site clefts [active]
243231004600	zinc binding site [ion binding]; other site
243231004601	dimer interface [polypeptide binding]; other site
243231004602	Signal transduction histidine kinase regulating citrate/malate metabolism [Signal transduction mechanisms]; Region: CitA; COG3290
243231004603	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
243231004604	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
243231004605	dimerization interface [polypeptide binding]; other site
243231004606	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
243231004607	dimer interface [polypeptide binding]; other site
243231004608	phosphorylation site [posttranslational modification]
243231004609	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
243231004610	ATP binding site [chemical binding]; other site
243231004611	Mg2+ binding site [ion binding]; other site
243231004612	G-X-G motif; other site
243231004613	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
243231004614	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
243231004615	active site
243231004616	phosphorylation site [posttranslational modification]
243231004617	intermolecular recognition site; other site
243231004618	dimerization interface [polypeptide binding]; other site
243231004619	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
243231004620	TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783
243231004621	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
243231004622	N-terminal plug; other site
243231004623	ligand-binding site [chemical binding]; other site
243231004624	putative geopeptide radical SAM maturase; Region: geopep_mat_rSAM; TIGR04280
243231004625	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
243231004626	FeS/SAM binding site; other site
243231004627	Domain of unknown function (DUF4008); Region: DUF4008; cl14869
243231004628	Predicted metal-dependent phosphoesterases (PHP family) [General function prediction only]; Region: COG0613
243231004629	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
243231004630	endonuclease III; Region: ENDO3c; smart00478
243231004631	minor groove reading motif; other site
243231004632	helix-hairpin-helix signature motif; other site
243231004633	substrate binding pocket [chemical binding]; other site
243231004634	active site
243231004635	Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; cl15304
243231004636	3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084
243231004637	TRAM domain; Region: TRAM; cl01282
243231004638	SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265
243231004639	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
243231004640	S-adenosylmethionine binding site [chemical binding]; other site
243231004641	HEAT repeats; Region: HEAT_2; pfam13646
243231004642	Glycosyltransferases, probably involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG1215
243231004643	CESA_like is  the cellulose synthase superfamily; Region: CESA_like; cd06423
243231004644	DXD motif; other site
243231004645	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
243231004646	binding surface
243231004647	TPR repeat; Region: TPR_11; pfam13414
243231004648	TPR motif; other site
243231004649	Putative catalytic NodB homology domain of PgaB, IcaB, and similar proteins which consist of a deformed (beta/alpha)8 barrel fold with 5- or 6-strands; Region: CE4_NodB_like_5s_6s; cd10918
243231004650	putative active site [active]
243231004651	putative metal binding site [ion binding]; other site
243231004652	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
243231004653	binding surface
243231004654	TPR motif; other site
243231004655	poly-beta-1,6 N-acetyl-D-glucosamine export porin PgaA; Region: PGA_TPR_OMP; TIGR03939
243231004656	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366
243231004657	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694
243231004658	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694
243231004659	prolyl-tRNA synthetase; Provisional; Region: PRK09194
243231004660	Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent formation of...; Region: ProRS_core_prok; cd00779
243231004661	dimer interface [polypeptide binding]; other site
243231004662	motif 1; other site
243231004663	active site
243231004664	motif 2; other site
243231004665	INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334
243231004666	putative deacylase active site [active]
243231004667	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it attaches...; Region: class_II_aaRS-like_core; cl00268
243231004668	active site
243231004669	motif 3; other site
243231004670	ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861
243231004671	anticodon binding site; other site
243231004672	Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase contains two...; Region: OMP_decarboxylase_like; cd04725
243231004673	active site
243231004674	dimer interface [polypeptide binding]; other site
243231004675	rRNA methylase, putative, group 3; Region: rRNA_methyl_3; TIGR00186
243231004676	RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; cl06870
243231004677	SpoU rRNA Methylase family; Region: SpoU_methylase; cl00362
243231004678	aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476
243231004679	EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317
243231004680	dimer interface [polypeptide binding]; other site
243231004681	anticodon binding site; other site
243231004682	Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of the...; Region: AspRS_core; cd00777
243231004683	homodimer interface [polypeptide binding]; other site
243231004684	motif 1; other site
243231004685	active site
243231004686	motif 2; other site
243231004687	GAD domain; Region: GAD; pfam02938
243231004688	Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of the...; Region: AspRS_core; cd00777
243231004689	motif 3; other site
243231004690	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
243231004691	Monomeric isocitrate dehydrogenase; Region: IDH; cl15383
243231004692	malate dehydrogenase; Reviewed; Region: PRK06223
243231004693	L-lactate dehydrogenase-like malate dehydrogenase proteins; Region: LDH-like_MDH; cd01339
243231004694	NAD(P) binding site [chemical binding]; other site
243231004695	dimer interface [polypeptide binding]; other site
243231004696	tetramer (dimer of dimers) interface [polypeptide binding]; other site
243231004697	substrate binding site [chemical binding]; other site
243231004698	RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409
243231004699	4Fe-4S dicluster domain; Region: Fer4_10; pfam13237
243231004700	2-oxoglutarate ferredoxin oxidoreductase subunit alpha; Validated; Region: PRK08659
243231004701	Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034
243231004702	dimer interface [polypeptide binding]; other site
243231004703	PYR/PP interface [polypeptide binding]; other site
243231004704	TPP binding site [chemical binding]; other site
243231004705	substrate binding site [chemical binding]; other site
243231004706	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
243231004707	2-oxoglutarate ferredoxin oxidoreductase subunit beta; Reviewed; Region: PRK11867
243231004708	Thiamine pyrophosphate (TPP family), 2-oxoglutarate ferredoxin oxidoreductase (OGFOR) subfamily, TPP-binding module; OGFOR catalyzes the oxidative decarboxylation of 2-oxo-acids, with ferredoxin acting as an electron acceptor. In the TCA cycle, OGFOR...; Region: TPP_OGFOR; cd03375
243231004709	TPP-binding site [chemical binding]; other site
243231004710	2-oxoglutarate ferredoxin oxidoreductase subunit gamma; Validated; Region: PRK08537
243231004711	Pyruvate ferredoxin/flavodoxin oxidoreductase; Region: POR; cl00546
243231004712	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
243231004713	Zn2+ binding site [ion binding]; other site
243231004714	Mg2+ binding site [ion binding]; other site
243231004715	Domain of unknown function (DUF4388); Region: DUF4388; pfam14332
243231004716	SNARE associated Golgi protein; Region: SNARE_assoc; cl00429
243231004717	rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: LasT; COG0565
243231004718	SpoU rRNA Methylase family; Region: SpoU_methylase; cl00362
243231004719	LemA family; Region: LemA; cl00742
243231004720	Repair protein; Region: Repair_PSII; cl01535
243231004721	Repair protein; Region: Repair_PSII; cl01535
243231004722	drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711
243231004723	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
243231004724	putative substrate translocation pore; other site
243231004725	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
243231004726	Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566
243231004727	Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404
243231004728	Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404
243231004729	type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844
243231004730	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
243231004731	Helix-turn-helix domains; Region: HTH; cl00088
243231004732	Helix-turn-helix domains; Region: HTH; cl00088
243231004733	putative PEP-CTERM system TPR-repeat lipoprotein; Region: PEP_TPR_lipo; TIGR02917
243231004734	Tetratricopeptide repeat; Region: TPR_6; pfam13174
243231004735	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
243231004736	binding surface
243231004737	TPR motif; other site
243231004738	lytic murein transglycosylase; Provisional; Region: PRK11619
243231004739	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic 'goose-type' lysozymes (GEWL).  LTs catalyze...; Region: LT_GEWL; cd00254
243231004740	N-acetyl-D-glucosamine binding site [chemical binding]; other site
243231004741	catalytic residue [active]
243231004742	ribonuclease R; Region: RNase_R; TIGR02063
243231004743	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
243231004744	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
243231004745	RNB domain; Region: RNB; pfam00773
243231004746	S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase play an important...; Region: S1_RNase_R; cd04471
243231004747	RNA binding site [nucleotide binding]; other site
243231004748	Sec-independent protein translocase protein (TatC); Region: TatC; cl00521
243231004749	bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627
243231004750	FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064
243231004751	active site
243231004752	Riboflavin kinase; Region: Flavokinase; cl03312
243231004753	Uncharacterized protein family (UPF0104); Region: UPF0104; cl04219
243231004754	Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl15769
243231004755	shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258
243231004756	Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501
243231004757	NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065
243231004758	shikimate binding site; other site
243231004759	NAD(P) binding site [chemical binding]; other site
243231004760	type IV-A pilus assembly ATPase PilB; Region: type_IV_pilB; TIGR02538
243231004761	Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157
243231004762	PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129
243231004763	Walker A motif; other site
243231004764	ATP binding site [chemical binding]; other site
243231004765	Walker B motif; other site
243231004766	pilus retraction protein PilT; Region: pilT_fam; TIGR01420
243231004767	Pilus retraction ATPase PilT. PilT is a nucleotide binding protein responsible for the retraction of type IV pili, likely by pili disassembly. This retraction provides the force required for travel of bacteria in low water environments by a mechanism...; Region: PilT; cd01131
243231004768	Walker A motif; other site
243231004769	ATP binding site [chemical binding]; other site
243231004770	Walker B motif; other site
243231004771	Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459
243231004772	Type II secretion system (T2SS), protein F; Region: T2SF; cl00906
243231004773	Type II secretion system (T2SS), protein F; Region: T2SF; cl00906
243231004774	Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852
243231004775	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
243231004776	putative active site [active]
243231004777	heme pocket [chemical binding]; other site
243231004778	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
243231004779	dimer interface [polypeptide binding]; other site
243231004780	phosphorylation site [posttranslational modification]
243231004781	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
243231004782	ATP binding site [chemical binding]; other site
243231004783	Mg2+ binding site [ion binding]; other site
243231004784	G-X-G motif; other site
243231004785	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
243231004786	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
243231004787	active site
243231004788	phosphorylation site [posttranslational modification]
243231004789	intermolecular recognition site; other site
243231004790	dimerization interface [polypeptide binding]; other site
243231004791	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
243231004792	Walker A motif; other site
243231004793	ATP binding site [chemical binding]; other site
243231004794	Walker B motif; other site
243231004795	arginine finger; other site
243231004796	Helix-turn-helix domains; Region: HTH; cl00088
243231004797	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
243231004798	TPR motif; other site
243231004799	Tetratricopeptide repeat; Region: TPR_12; pfam13424
243231004800	binding surface
243231004801	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
243231004802	binding surface
243231004803	TPR motif; other site
243231004804	This family of ATP-binding proteins belongs to a multisubunit transporter involved in drug resistance (BcrA and DrrA), nodulation, lipid transport, and lantibiotic immunity.  In bacteria and archaea, these transporters usually include an ATP-binding...; Region: ABC_DR_subfamily_A; cd03230
243231004805	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
243231004806	Walker A/P-loop; other site
243231004807	ATP binding site [chemical binding]; other site
243231004808	Q-loop/lid; other site
243231004809	ABC transporter signature motif; other site
243231004810	Walker B; other site
243231004811	D-loop; other site
243231004812	H-loop/switch region; other site
243231004813	UbiA prenyltransferase family; Region: UbiA; cl00337
243231004814	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
243231004815	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
243231004816	active site
243231004817	ABC-2 type transporter; Region: ABC2_membrane; cl11417
243231004818	ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134
243231004819	ABC_KpsT_Wzt   The KpsT/Wzt ABC transporter subfamily is involved in extracellular polysaccharide export.  Among the variety of membrane-linked or extracellular polysaccharides excreted by bacteria, only capsular polysaccharides, lipopolysaccharides, and...; Region: ABC_KpsT_Wzt; cd03220
243231004820	Walker A/P-loop; other site
243231004821	ATP binding site [chemical binding]; other site
243231004822	Q-loop/lid; other site
243231004823	ABC transporter signature motif; other site
243231004824	Walker B; other site
243231004825	D-loop; other site
243231004826	H-loop/switch region; other site
243231004827	C-Terminal domain of O-antigenic polysaccharide transporter protein Wzt and related proteins; Region: Wzt_C-like; cd10147
243231004828	putative carbohydrate binding site [chemical binding]; other site
243231004829	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911
243231004830	ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859
243231004831	Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789
243231004832	putative active site [active]
243231004833	Glycosyl hydrolase family 99-like domain of WbsX-like glycosyltransferases; Region: Glyco_tran_WbsX; cd11579
243231004834	putative ligand binding site [chemical binding]; other site
243231004835	putative catalytic site [active]
243231004836	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
243231004837	Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_d; cd04196
243231004838	Probable Catalytic site; other site
243231004839	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
243231004840	active site
243231004841	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
243231004842	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
243231004843	active site
243231004844	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
243231004845	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
243231004846	hypothetical protein; Provisional; Region: PRK07208
243231004847	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
243231004848	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
243231004849	S-adenosylmethionine binding site [chemical binding]; other site
243231004850	ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859
243231004851	Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789
243231004852	putative active site [active]
243231004853	threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413
243231004854	TGS _ThrRS_N:  ThrRS (threonyl-tRNA Synthetase)  is a class II tRNA synthetase that couples threonine to its cognate tRNA.  In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667
243231004855	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; cl08469
243231004856	Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771
243231004857	active site
243231004858	dimer interface [polypeptide binding]; other site
243231004859	motif 1; other site
243231004860	motif 2; other site
243231004861	motif 3; other site
243231004862	ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860
243231004863	anticodon binding site; other site
243231004864	translation initiation factor IF-3; Reviewed; Region: infC; PRK00028
243231004865	Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198
243231004866	Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707
243231004867	Ribosomal protein L35; Region: Ribosomal_L35p; cl00392
243231004868	Ribosomal protein L20; Region: Ribosomal_L20; cd07026
243231004869	23S rRNA binding site [nucleotide binding]; other site
243231004870	L21 binding site [polypeptide binding]; other site
243231004871	L13 binding site [polypeptide binding]; other site
243231004872	phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488
243231004873	Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912
243231004874	Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496
243231004875	dimer interface [polypeptide binding]; other site
243231004876	motif 1; other site
243231004877	active site
243231004878	motif 2; other site
243231004879	motif 3; other site
243231004880	phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629
243231004881	tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain.  PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796
243231004882	putative tRNA-binding site [nucleotide binding]; other site
243231004883	B3/4 domain; Region: B3_4; cl11458
243231004884	tRNA synthetase B5 domain; Region: B5; cl08394
243231004885	Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA,  PheRS is an...; Region: PheRS_beta_core; cd00769
243231004886	dimer interface [polypeptide binding]; other site
243231004887	motif 1; other site
243231004888	motif 3; other site
243231004889	motif 2; other site
243231004890	Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; cl08386
243231004891	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
243231004892	IHF dimer interface [polypeptide binding]; other site
243231004893	IHF - DNA interface [nucleotide binding]; other site
243231004894	Helix-Turn-Helix DNA binding domain of putative MlrA-like transcription regulators; Region: HTH_MlrA-like_sg2; cd04765
243231004895	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
243231004896	DNA binding residues [nucleotide binding]
243231004897	Survival protein SurE; Region: SurE; cl00448
243231004898	protein-L-isoaspartate O-methyltransferase; Reviewed; Region: pcm; PRK00312
243231004899	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
243231004900	S-adenosylmethionine binding site [chemical binding]; other site
243231004901	Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140
243231004902	RNA polymerase sigma factor RpoS; Region: rpoS_proteo; TIGR02394
243231004903	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
243231004904	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
243231004905	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
243231004906	DNA binding residues [nucleotide binding]
243231004907	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
243231004908	active site
243231004909	L-cysteine desulfidase [Amino acid transport and metabolism]; Region: COG3681
243231004910	Serine dehydratase alpha chain; Region: SDH_alpha; cl12120
243231004911	Serine dehydratase alpha chain; Region: SDH_alpha; cl12120
243231004912	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
243231004913	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
243231004914	substrate binding pocket [chemical binding]; other site
243231004915	membrane-bound complex binding site; other site
243231004916	hinge residues; other site
243231004917	Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852
243231004918	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
243231004919	putative active site [active]
243231004920	heme pocket [chemical binding]; other site
243231004921	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
243231004922	dimer interface [polypeptide binding]; other site
243231004923	phosphorylation site [posttranslational modification]
243231004924	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
243231004925	ATP binding site [chemical binding]; other site
243231004926	Mg2+ binding site [ion binding]; other site
243231004927	G-X-G motif; other site
243231004928	Response regulator receiver domain; Region: Response_reg; pfam00072
243231004929	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
243231004930	active site
243231004931	phosphorylation site [posttranslational modification]
243231004932	intermolecular recognition site; other site
243231004933	dimerization interface [polypeptide binding]; other site
243231004934	ATP phosphoribosyltransferase; Reviewed; Region: hisG; PRK00489
243231004935	ATP phosphoribosyltransferase; Region: HisG; cl15266
243231004936	HisG, C-terminal domain; Region: HisG_C; cl06867
243231004937	Phosphoribosyl-AMP cyclohydrolase; Region: PRA-CH; cl00344
243231004938	TSCPD domain; Region: TSCPD; cl14834
243231004939	Exodeoxyribonuclease V, gamma subunit; Region: Exonuc_V_gamma; pfam04257
243231004940	exonuclease V subunit gamma; Provisional; Region: recC; PRK11069
243231004941	exonuclease V subunit beta; Provisional; Region: recB; PRK10876
243231004942	exodeoxyribonuclease V, alpha subunit; Region: recD; TIGR01447
243231004943	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
243231004944	Family description; Region: UvrD_C_2; cl15862
243231004945	putative secretion ATPase, PEP-CTERM locus subfamily; Region: pepcterm_ATPase; TIGR03015
243231004946	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
243231004947	Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the 'double-glycine' leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic). The cleavage...; Region: Peptidase_C39_like; cl00296
243231004948	putative active site [active]
243231004949	Putative peptidoglycan binding domain; Region: PG_binding_1; cl15437
243231004950	Cytochrome c peroxidase [Inorganic ion transport and metabolism]; Region: MauG; COG1858
243231004951	Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086
243231004952	putative catalytic site [active]
243231004953	putative phosphate binding site [ion binding]; other site
243231004954	active site
243231004955	metal binding site A [ion binding]; metal-binding site
243231004956	DNA binding site [nucleotide binding]
243231004957	putative AP binding site [nucleotide binding]; other site
243231004958	putative metal binding site B [ion binding]; other site
243231004959	FG-GAP repeat; Region: FG-GAP; cl15299
243231004960	Family description; Region: VCBS; pfam13517
243231004961	Family description; Region: VCBS; pfam13517
243231004962	Family description; Region: VCBS; pfam13517
243231004963	Family description; Region: VCBS; pfam13517
243231004964	FG-GAP repeat; Region: FG-GAP; cl15299
243231004965	Family description; Region: VCBS; pfam13517
243231004966	Transposase IS200 like; Region: Y1_Tnp; cl00848
243231004967	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761
243231004968	Protein of unknown function (DUF2845); Region: DUF2845; pfam11006
243231004969	LysE type translocator; Region: LysE; cl00565
243231004970	TPR repeat; Region: TPR_11; pfam13414
243231004971	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
243231004972	binding surface
243231004973	TPR motif; other site
243231004974	TPR repeat; Region: TPR_11; pfam13414
243231004975	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
243231004976	ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859
243231004977	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
243231004978	Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cl00264
243231004979	dinuclear metal binding motif [ion binding]; other site
243231004980	Transglutaminase-like superfamily; Region: Transglut_core; cl10469
243231004981	4-Oxalocrotonate Tautomerase:  Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235
243231004982	active site 1 [active]
243231004983	dimer interface [polypeptide binding]; other site
243231004984	hexamer interface [polypeptide binding]; other site
243231004985	active site 2 [active]
243231004986	Signal transduction histidine kinase, nitrate/nitrite-specific [Signal transduction mechanisms]; Region: NarQ; COG3850
243231004987	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
243231004988	dimerization interface [polypeptide binding]; other site
243231004989	Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cl00120
243231004990	The Death Domain Superfamily of protein-protein interaction domains; Region: DD_superfamily; cl14633
243231004991	Domain of unknown function (DUF1987); Region: DUF1987; pfam09345
243231004992	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
243231004993	metal binding site [ion binding]; metal-binding site
243231004994	active site
243231004995	I-site; other site
243231004996	ECF-type riboflavin transporter, S component; Region: ECF-ribofla_trS; cl01942
243231004997	PAS domain S-box; Region: sensory_box; TIGR00229
243231004998	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
243231004999	putative active site [active]
243231005000	heme pocket [chemical binding]; other site
243231005001	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459
243231005002	PAS domain; Region: PAS_9; pfam13426
243231005003	GAF domain; Region: GAF; cl15785
243231005004	PAS domain S-box; Region: sensory_box; TIGR00229
243231005005	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
243231005006	putative active site [active]
243231005007	heme pocket [chemical binding]; other site
243231005008	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
243231005009	dimer interface [polypeptide binding]; other site
243231005010	phosphorylation site [posttranslational modification]
243231005011	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
243231005012	ATP binding site [chemical binding]; other site
243231005013	Mg2+ binding site [ion binding]; other site
243231005014	G-X-G motif; other site
243231005015	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
243231005016	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
243231005017	active site
243231005018	phosphorylation site [posttranslational modification]
243231005019	intermolecular recognition site; other site
243231005020	dimerization interface [polypeptide binding]; other site
243231005021	Domain of unknown function (DUF4382); Region: DUF4382; pfam14321
243231005022	Mechanosensitive ion channel; Region: MS_channel; pfam00924
243231005023	Predicted Fe-S oxidoreductases [General function prediction only]; Region: COG0535
243231005024	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
243231005025	FeS/SAM binding site; other site
243231005026	Domain of unknown function (DUF4008); Region: DUF4008; cl14869
243231005027	Transglycosylase; Region: Transgly; cl07896
243231005028	penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074
243231005029	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009
243231005030	Domain of unknown function DUF77; Region: DUF77; cl00307
243231005031	glutamate dehydrogenase 2; Provisional; Region: PTZ00324
243231005032	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
243231005033	Nucleoside 2-deoxyribosyltransferase; Region: Nuc_deoxyrib_tr; cl16918
243231005034	Peptidase family M48; Region: Peptidase_M48; cl12018
243231005035	Transcription factor zinc-finger; Region: zf-TFIIB; cl01565
243231005036	Ribbon-helix-helix protein, copG family; Region: RHH_1; cl15783
243231005037	Integral membrane protein TerC family; Region: TerC; cl10468
243231005038	Uncharacterized protein family (UPF0157); Region: UPF0157; cl00987
243231005039	Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cl00161
243231005040	folate binding site [chemical binding]; other site
243231005041	NADP+ binding site [chemical binding]; other site
243231005042	CAAX protease self-immunity; Region: Abi; cl00558
243231005043	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911
243231005044	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
243231005045	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
243231005046	NAD(P) binding site [chemical binding]; other site
243231005047	active site
243231005048	ATP:corrinoid adenosyltransferase BtuR/CobO/CobP. This family consists of the BtuR, CobO, CobP proteins all of which are Cob(I)alamin (vitamin B12) adenosyltransferase, which is involved in cobalamin (vitamin B12) biosynthesis. This enzyme is a homodimer; Region: CobA_CobO_BtuR; cd00561
243231005049	homodimer interface [polypeptide binding]; other site
243231005050	Walker A motif; other site
243231005051	ATP binding site [chemical binding]; other site
243231005052	hydroxycobalamin binding site [chemical binding]; other site
243231005053	Walker B motif; other site
243231005054	methylmalonyl CoA mutase B12 binding domain. This domain binds to B12 (adenosylcobamide), which initiates the conversion of succinyl CoA and methylmalonyl CoA by forming an adenosyl radical, which then undergoes a rearrangement exchanging a hydrogen atom...; Region: MM_CoA_mut_B12_BD; cd02071
243231005055	B12 binding site [chemical binding]; other site
243231005056	cobalt ligand [ion binding]; other site
243231005057	ArgK protein; Region: ArgK; pfam03308
243231005058	The function of this protein family is unkown. The protein sequences are similar to the ArgK protein in E. coli. ArgK protein is a membrane ATPase which is required for transporting arginine, ornithine and lysine into the cells by the arginine and...; Region: ArgK-like; cd03114
243231005059	Walker A; other site
243231005060	L,D-transpeptidase catalytic domain; Region: YkuD; cl15405
243231005061	Predicted signaling protein consisting of a modified GGDEF domain and a DHH domain [Signal transduction mechanisms]; Region: COG3887
243231005062	DHH family; Region: DHH; pfam01368
243231005063	FOG: CBS domain [General function prediction only]; Region: COG0517
243231005064	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with an upstream DHH domain which performs a phosphoesterase function and a downstream polyA polymerase domain. CBS is a small domain originally...; Region: CBS_pair_DHH_polyA_Pol_assoc; cd04595
243231005065	tRNA nucleotidyltransferase/poly(A) polymerase [Translation, ribosomal structure and biogenesis]; Region: PcnB; COG0617
243231005066	Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398
243231005067	active site
243231005068	NTP binding site [chemical binding]; other site
243231005069	metal binding triad [ion binding]; metal-binding site
243231005070	Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627
243231005071	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
243231005072	adenosylmethionine-8-amino-7-oxononanoate transaminase; Region: bioA; TIGR00508
243231005073	inhibitor-cofactor binding pocket; inhibition site
243231005074	pyridoxal 5'-phosphate binding site [chemical binding]; other site
243231005075	catalytic residue [active]
243231005076	AAA domain; Region: AAA_26; pfam13500
243231005077	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
243231005078	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
243231005079	biotin synthase; Region: bioB; TIGR00433
243231005080	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
243231005081	FeS/SAM binding site; other site
243231005082	Biotin and Thiamin Synthesis associated domain; Region: BATS; cl06149
243231005083	ribosome maturation protein RimP; Reviewed; Region: PRK00092
243231005084	The eukaryotic Sm and Sm-like (LSm) proteins associate with RNA to form the core domain of the ribonucleoprotein particles involved in a variety of RNA processing events including pre-mRNA splicing, telomere replication, and mRNA degradation.  Members of...; Region: Sm_like; cl00259
243231005085	YxlS is a Bacillus subtilis gene of unknown function with two domains that each have an alpha/beta fold.  The N-terminal domain is composed of two alpha-helices and a three-stranded beta-sheet, while the C-terminal domain is composed of one alpha-helix...; Region: YlxS_C; cd01734
243231005086	Sm1 motif; other site
243231005087	predicted subunit interaction site [polypeptide binding]; other site
243231005088	RNA binding pocket [nucleotide binding]; other site
243231005089	Sm2 motif; other site
243231005090	NusA N-terminal domain; Region: NusA_N; pfam08529
243231005091	transcription elongation factor NusA; Provisional; Region: nusA; PRK12327
243231005092	S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455
243231005093	RNA binding site [nucleotide binding]; other site
243231005094	homodimer interface [polypeptide binding]; other site
243231005095	KH-II  (K homology RNA-binding domain, type II). KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins  (e.g. ribosomal protein S3), transcription factors (e.g. NusA_K), and post-transcriptional...; Region: KH-II; cl00098
243231005096	NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134
243231005097	G-X-X-G motif; other site
243231005098	Ylxr homologs; group of conserved hypothetical bacterial proteins of unknown function; structure revealed putative RNA binding cleft; proteins are encoded by an operon that includes other proteins involved in transcription and/or translation; Region: YlxR; cd00279
243231005099	putative RNA binding cleft [nucleotide binding]; other site
243231005100	Ribosomal protein L7Ae/L30e/S12e/Gadd45 family; Region: Ribosomal_L7Ae; cl00600
243231005101	Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760
243231005102	translation initiation factor IF-2; Region: IF-2; TIGR00487
243231005103	Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760
243231005104	Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887
243231005105	G1 box; other site
243231005106	putative GEF interaction site [polypeptide binding]; other site
243231005107	GTP/Mg2+ binding site [chemical binding]; other site
243231005108	Switch I region; other site
243231005109	G2 box; other site
243231005110	G3 box; other site
243231005111	Switch II region; other site
243231005112	G4 box; other site
243231005113	G5 box; other site
243231005114	This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702
243231005115	Translation-initiation factor 2; Region: IF-2; pfam11987
243231005116	mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692
243231005117	Ribosome-binding factor A; Region: RBFA; cl00542
243231005118	Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618
243231005119	DHH family; Region: DHH; pfam01368
243231005120	tRNA pseudouridine synthase B; Provisional; Region: truB; PRK05389
243231005121	Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573
243231005122	RNA binding site [nucleotide binding]; other site
243231005123	active site
243231005124	Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353
243231005125	16S/18S rRNA binding site [nucleotide binding]; other site
243231005126	S13e-L30e interaction site [polypeptide binding]; other site
243231005127	25S rRNA binding site [nucleotide binding]; other site
243231005128	polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824
243231005129	Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363
243231005130	RNase E interface [polypeptide binding]; other site
243231005131	trimer interface [polypeptide binding]; other site
243231005132	Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726
243231005133	Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364
243231005134	RNase E interface [polypeptide binding]; other site
243231005135	trimer interface [polypeptide binding]; other site
243231005136	active site
243231005137	Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393
243231005138	putative nucleic acid binding region [nucleotide binding]; other site
243231005139	G-X-X-G motif; other site
243231005140	S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase  is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472
243231005141	RNA binding site [nucleotide binding]; other site
243231005142	domain interface; other site
243231005143	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
243231005144	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
243231005145	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
243231005146	Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557
243231005147	trimer interface [polypeptide binding]; other site
243231005148	active site
243231005149	Telomere recombination; Region: Sua5_yciO_yrdC; cl00305
243231005150	Uncharacterized ACR, COG1399; Region: DUF177; cl00616
243231005151	Ribosomal L32p protein family; Region: Ribosomal_L32p; cl09115
243231005152	Phosphate acetyl/butaryl transferase; Region: PTA_PTB; cl00390
243231005153	3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352
243231005154	Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830
243231005155	dimer interface [polypeptide binding]; other site
243231005156	active site
243231005157	CoA binding pocket [chemical binding]; other site
243231005158	Acyl transferase domain; Region: Acyl_transf_1; cl08282
243231005159	malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128
243231005160	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557
243231005161	beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333
243231005162	NAD(P) binding site [chemical binding]; other site
243231005163	homotetramer interface [polypeptide binding]; other site
243231005164	homodimer interface [polypeptide binding]; other site
243231005165	active site
243231005166	Phosphopantetheine attachment site; Region: PP-binding; cl09936
243231005167	beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150
243231005168	Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834
243231005169	dimer interface [polypeptide binding]; other site
243231005170	active site
243231005171	Ribose/Galactose Isomerase; Region: LacAB_rpiB; cl00485
243231005172	serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011
243231005173	Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378
243231005174	dimer interface [polypeptide binding]; other site
243231005175	active site
243231005176	glycine-pyridoxal phosphate binding site [chemical binding]; other site
243231005177	folate binding site [chemical binding]; other site
243231005178	Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538
243231005179	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
243231005180	Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404
243231005181	Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404
243231005182	multidrug efflux system subunit MdtB; Provisional; Region: PRK10503
243231005183	Protein export membrane protein; Region: SecD_SecF; cl14618
243231005184	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
243231005185	catalytic core [active]
243231005186	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
243231005187	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
243231005188	endonuclease III; Region: ENDO3c; smart00478
243231005189	minor groove reading motif; other site
243231005190	helix-hairpin-helix signature motif; other site
243231005191	substrate binding pocket [chemical binding]; other site
243231005192	active site
243231005193	Helix-turn-helix domains; Region: HTH; cl00088
243231005194	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
243231005195	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
243231005196	DNA polymerase IV; Reviewed; Region: PRK03103
243231005197	DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586
243231005198	active site
243231005199	DNA binding site [nucleotide binding]
243231005200	Domain of unknown function (DUF4113); Region: DUF4113; pfam13438
243231005201	LexA repressor; Validated; Region: PRK00215
243231005202	Helix-turn-helix domains; Region: HTH; cl00088
243231005203	Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529
243231005204	Catalytic site [active]
243231005205	chain length determinant protein tyrosine kinase EpsG; Region: EpsG; TIGR03029
243231005206	Chemotaxis phosphatase CheX; Region: CheX; cl15816
243231005207	Response regulator receiver domain; Region: Response_reg; pfam00072
243231005208	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
243231005209	active site
243231005210	phosphorylation site [posttranslational modification]
243231005211	intermolecular recognition site; other site
243231005212	dimerization interface [polypeptide binding]; other site
243231005213	Uncharacterized conserved protein containing a ferredoxin-like domain [Energy production and conversion]; Region: COG1139
243231005214	Uncharacterized ACR, YkgG family COG1556; Region: DUF162; cl00674
243231005215	Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247
243231005216	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
243231005217	Cysteine-rich domain; Region: CCG; pfam02754
243231005218	Cysteine-rich domain; Region: CCG; pfam02754
243231005219	Uncharacterized ACR, YkgG family COG1556; Region: DUF162; cl00674
243231005220	L-lactate permease; Region: Lactate_perm; cl00701
243231005221	L-lactate permease; Region: Lactate_perm; cl00701
243231005222	FAD binding domain; Region: FAD_binding_4; pfam01565
243231005223	glycolate oxidase, subunit GlcD; Region: glcD; TIGR00387
243231005224	Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247
243231005225	Cysteine-rich domain; Region: CCG; pfam02754
243231005226	Cysteine-rich domain; Region: CCG; pfam02754
243231005227	Transcriptional regulators [Transcription]; Region: FadR; COG2186
243231005228	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
243231005229	DNA-binding site [nucleotide binding]; DNA binding site
243231005230	FCD domain; Region: FCD; cl11656
243231005231	Preprotein translocase SecG subunit; Region: SecG; cl09123
243231005232	bifunctional phosphoglycerate kinase/triosephosphate isomerase; Provisional; Region: PRK13962
243231005233	Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318
243231005234	substrate binding site [chemical binding]; other site
243231005235	hinge regions; other site
243231005236	ADP binding site [chemical binding]; other site
243231005237	catalytic site [active]
243231005238	Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311
243231005239	substrate binding site [chemical binding]; other site
243231005240	dimer interface [polypeptide binding]; other site
243231005241	catalytic triad [active]
243231005242	glyceraldehyde-3-phosphate dehydrogenase; Validated; Region: PRK07729
243231005243	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
243231005244	Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; cl15856
243231005245	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: VicK; COG5002
243231005246	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
243231005247	dimerization interface [polypeptide binding]; other site
243231005248	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459
243231005249	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
243231005250	dimer interface [polypeptide binding]; other site
243231005251	phosphorylation site [posttranslational modification]
243231005252	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
243231005253	ATP binding site [chemical binding]; other site
243231005254	Mg2+ binding site [ion binding]; other site
243231005255	G-X-G motif; other site
243231005256	Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446
243231005257	adenylosuccinate lyase; Provisional; Region: PRK07492
243231005258	Adenylsuccinate lyase (ASL)_subgroup 1; Region: Adenylsuccinate_lyase_1; cd01360
243231005259	tetramer interface [polypeptide binding]; other site
243231005260	active site
243231005261	Mechanosensitive ion channel; Region: MS_channel; pfam00924
243231005262	Phosphoribosylformylglycinamidine (FGAM) synthase; Region: PurS; cl00789
243231005263	Phosphoribosylformylglycinamidine (FGAM) synthase, synthetase domain [Nucleotide transport and metabolism]; Region: PurL; COG0046
243231005264	PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203
243231005265	dimerization interface [polypeptide binding]; other site
243231005266	ATP binding site [chemical binding]; other site
243231005267	PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204
243231005268	dimerization interface [polypeptide binding]; other site
243231005269	ATP binding site [chemical binding]; other site
243231005270	Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020
243231005271	conserved cys residue [active]
243231005272	amidophosphoribosyltransferase; Provisional; Region: PRK09123
243231005273	Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of  glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715
243231005274	active site
243231005275	tetramer interface [polypeptide binding]; other site
243231005276	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
243231005277	active site
243231005278	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
243231005279	active site
243231005280	Flagellin N-methylase; Region: FliB; cl00497
243231005281	Rrf2 family protein; Region: rrf2_super; TIGR00738
243231005282	Helix-turn-helix domains; Region: HTH; cl00088
243231005283	Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; cl00562
243231005284	cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219
243231005285	Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322
243231005286	Uncharacterized family of ferritin-like proteins found in archaea and bacteria; Region: Ferritin_like_AB; cd01045
243231005287	diiron binding motif [ion binding]; other site
243231005288	Response regulator receiver domain; Region: Response_reg; pfam00072
243231005289	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
243231005290	active site
243231005291	phosphorylation site [posttranslational modification]
243231005292	intermolecular recognition site; other site
243231005293	dimerization interface [polypeptide binding]; other site
243231005294	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
243231005295	metal binding site [ion binding]; metal-binding site
243231005296	active site
243231005297	I-site; other site
243231005298	putative ABC transporter ATP-binding protein; Reviewed; Region: PRK11819
243231005299	ABCF_EF-3  Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth.  EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221
243231005300	ABCF_EF-3  Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth.  EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221
243231005301	ABC transporter; Region: ABC_tran_2; pfam12848
243231005302	ABCF_EF-3  Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth.  EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221
243231005303	potential protein location (hypothetical protein) that overlaps protein (lipoprotein, )
243231005304	Seven times multi-haem cytochrome CxxCH; Region: Multi-haem_cyto; pfam13447
243231005305	Cytochrome c554 and c-prime; Region: Cytochrome_C554; pfam13435
243231005306	Cytochrome b subunit of the bc complex [Energy production and conversion]; Region: QcrB; COG1290
243231005307	Cytochrome b (N-terminus)/b6/petB:  Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cd00284
243231005308	intrachain domain interface; other site
243231005309	interchain domain interface [polypeptide binding]; other site
243231005310	heme bH binding site [chemical binding]; other site
243231005311	heme bL binding site [chemical binding]; other site
243231005312	Qo binding site; other site
243231005313	Cytochrome b(C-terminus)/b6/petD:  Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: cytochrome_b_C; cl00193
243231005314	interchain domain interface [polypeptide binding]; other site
243231005315	intrachain domain interface; other site
243231005316	Qi binding site; other site
243231005317	Qo binding site; other site
243231005318	Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938
243231005319	iron-sulfur cluster [ion binding]; other site
243231005320	[2Fe-2S] cluster binding site [ion binding]; other site
243231005321	Fructose-1,6-bisphosphatase, an enzyme that catalyzes the hydrolysis of fructose-1,6-biphosphate  into fructose-6-phosphate and is critical in gluconeogenesis pathway. The alignment model also includes chloroplastic FBPases and sedoheptulose-1; Region: FBPase; cd00354
243231005322	AMP binding site [chemical binding]; other site
243231005323	metal binding site [ion binding]; metal-binding site
243231005324	active site
243231005325	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
243231005326	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
243231005327	active site
243231005328	phosphorylation site [posttranslational modification]
243231005329	intermolecular recognition site; other site
243231005330	dimerization interface [polypeptide binding]; other site
243231005331	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
243231005332	Walker A motif; other site
243231005333	ATP binding site [chemical binding]; other site
243231005334	Walker B motif; other site
243231005335	arginine finger; other site
243231005336	Helix-turn-helix domains; Region: HTH; cl00088
243231005337	Response regulator containing a CheY-like receiver domain and an HD-GYP domain [Transcription / Signal transduction mechanisms]; Region: COG3437
243231005338	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
243231005339	active site
243231005340	phosphorylation site [posttranslational modification]
243231005341	intermolecular recognition site; other site
243231005342	dimerization interface [polypeptide binding]; other site
243231005343	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
243231005344	Zn2+ binding site [ion binding]; other site
243231005345	Mg2+ binding site [ion binding]; other site
243231005346	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
243231005347	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
243231005348	active site
243231005349	phosphorylation site [posttranslational modification]
243231005350	intermolecular recognition site; other site
243231005351	dimerization interface [polypeptide binding]; other site
243231005352	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
243231005353	PAS domain; Region: PAS_9; pfam13426
243231005354	putative active site [active]
243231005355	heme pocket [chemical binding]; other site
243231005356	GAF domain; Region: GAF_2; pfam13185
243231005357	GAF domain; Region: GAF; cl15785
243231005358	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
243231005359	dimer interface [polypeptide binding]; other site
243231005360	phosphorylation site [posttranslational modification]
243231005361	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
243231005362	ATP binding site [chemical binding]; other site
243231005363	Mg2+ binding site [ion binding]; other site
243231005364	G-X-G motif; other site
243231005365	Response regulator receiver domain; Region: Response_reg; pfam00072
243231005366	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
243231005367	active site
243231005368	phosphorylation site [posttranslational modification]
243231005369	intermolecular recognition site; other site
243231005370	dimerization interface [polypeptide binding]; other site
243231005371	Response regulator receiver domain; Region: Response_reg; pfam00072
243231005372	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
243231005373	active site
243231005374	phosphorylation site [posttranslational modification]
243231005375	intermolecular recognition site; other site
243231005376	dimerization interface [polypeptide binding]; other site
243231005377	PAS domain S-box; Region: sensory_box; TIGR00229
243231005378	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
243231005379	putative active site [active]
243231005380	heme pocket [chemical binding]; other site
243231005381	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
243231005382	metal binding site [ion binding]; metal-binding site
243231005383	active site
243231005384	I-site; other site
243231005385	Domain of unknown function (DUF4131); Region: DUF4131; pfam13567
243231005386	DNA internalization-related competence protein ComEC/Rec2; Region: ComEC_Rec2; TIGR00361
243231005387	Competence protein; Region: Competence; cl00471
243231005388	Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446
243231005389	Response regulator receiver domain; Region: Response_reg; pfam00072
243231005390	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
243231005391	active site
243231005392	phosphorylation site [posttranslational modification]
243231005393	intermolecular recognition site; other site
243231005394	dimerization interface [polypeptide binding]; other site
243231005395	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
243231005396	metal binding site [ion binding]; metal-binding site
243231005397	active site
243231005398	I-site; other site
243231005399	histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037
243231005400	Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: HisRS-like_core; cd00773
243231005401	dimer interface [polypeptide binding]; other site
243231005402	motif 1; other site
243231005403	active site
243231005404	motif 2; other site
243231005405	motif 3; other site
243231005406	HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859
243231005407	anticodon binding site; other site
243231005408	bifunctional aconitate hydratase 2/2-methylisocitrate dehydratase; Validated; Region: PRK09238
243231005409	Aconitase B swivel domain. Aconitate hydratase B is involved in energy metabolism as part of the TCA cycle. It catalyses the formation of cis-aconitate from citrate. This is the aconitase swivel domain, which undergoes swivelling conformational change in...; Region: AcnB_Swivel; cd01576
243231005410	substrate binding site [chemical binding]; other site
243231005411	Aconitate hydratase B catalyses the formation of cis-aconitate from citrate as part of the TCA cycle; Region: AcnB; cd01581
243231005412	substrate binding site [chemical binding]; other site
243231005413	ligand binding site [chemical binding]; other site
243231005414	Uridine phosphorylase [Nucleotide transport and metabolism]; Region: Udp; COG2820
243231005415	Phosphorylase superfamily; Region: PNP_UDP_1; cl00303
243231005416	Domain of unknown function (DUF309); Region: DUF309; cl00667
243231005417	Rhomboid family; Region: Rhomboid; cl11446
243231005418	RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409
243231005419	4Fe-4S dicluster domain; Region: Fer4_7; pfam12838
243231005420	Domain of unknown function (DUF2007); Region: DUF2007; pfam09413
243231005421	Response regulator receiver domain; Region: Response_reg; pfam00072
243231005422	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
243231005423	active site
243231005424	phosphorylation site [posttranslational modification]
243231005425	intermolecular recognition site; other site
243231005426	dimerization interface [polypeptide binding]; other site
243231005427	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
243231005428	metal binding site [ion binding]; metal-binding site
243231005429	active site
243231005430	I-site; other site
243231005431	glycerate dehydrogenase; Provisional; Region: PRK06487
243231005432	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
243231005433	Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318
243231005434	AMP-binding enzyme; Region: AMP-binding; cl15778
243231005435	Phosphopantetheine attachment site; Region: PP-binding; cl09936
243231005436	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
243231005437	putative acyl-acceptor binding pocket; other site
243231005438	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474
243231005439	Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; cl02930
243231005440	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
243231005441	Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246
243231005442	Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391
243231005443	Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689
243231005444	Archease protein family (MTH1598/TM1083); Region: Archease; cl00606
243231005445	AAA domain; Region: AAA_26; pfam13500
243231005446	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
243231005447	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
243231005448	DRTGG domain; Region: DRTGG; cl12147
243231005449	Protein of unknown function (DUF327); Region: DUF327; cl00753
243231005450	Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein; Region: Hint; cl15780
243231005451	hypothetical protein; Reviewed; Region: PRK09588
243231005452	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076
243231005453	Deoxycytidylate deaminase domain. Deoxycytidylate deaminase catalyzes the deamination of dCMP to dUMP, providing the nucleotide substrate for thymidylate synthase. The enzyme binds Zn++, which is required for catalytic activity. The activity of the...; Region: deoxycytidylate_deaminase; cd01286
243231005454	catalytic motif [active]
243231005455	Zn binding site [ion binding]; other site
243231005456	transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464
243231005457	Restriction alleviation protein Lar; Region: Lar_restr_allev; cl08047
243231005458	ATP cone domain; Region: ATP-cone; pfam03477
243231005459	riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326
243231005460	Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284
243231005461	catalytic motif [active]
243231005462	Zn binding site [ion binding]; other site
243231005463	Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cl00161
243231005464	riboflavin synthase subunit alpha; Provisional; Region: PRK09289
243231005465	Lumazine binding domain; Region: Lum_binding; pfam00677
243231005466	Lumazine binding domain; Region: Lum_binding; pfam00677
243231005467	bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09311
243231005468	3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; cl00336
243231005469	GTP cyclohydrolase II (RibA).  GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641
243231005470	dimerization interface [polypeptide binding]; other site
243231005471	active site
243231005472	lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209
243231005473	homopentamer interface [polypeptide binding]; other site
243231005474	active site
243231005475	Transcription termination factor NusB (N protein-Utilization Substance B). NusB plays a key role in the regulation of ribosomal RNA biosynthesis in eubacteria by modulating the efficiency of transcriptional antitermination. NusB along with other Nus...; Region: Terminator_NusB; cd00619
243231005476	putative RNA binding site [nucleotide binding]; other site
243231005477	homoserine dehydrogenase; Provisional; Region: PRK06349
243231005478	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
243231005479	Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742
243231005480	ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881
243231005481	Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391
243231005482	Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011
243231005483	Threonine synthase [Amino acid transport and metabolism]; Region: ThrC; COG0498
243231005484	Threonine synthase catalyzes the final step of threonine biosynthesis. The conversion of O-phosphohomoserine into threonine and inorganic phosphate is pyridoxal 5'-phosphate dependent. The Thr-synth_1 CD includes members from higher plants, cyanobacteria; Region: Thr-synth_2; cd01560
243231005485	pyridoxal 5'-phosphate binding site [chemical binding]; other site
243231005486	catalytic residue [active]
243231005487	MoxR-like ATPases [General function prediction only]; Region: COG0714
243231005488	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
243231005489	Domain of unknown function (DUF3488); Region: DUF3488; pfam11992
243231005490	Transglutaminase-like superfamily; Region: Transglut_core; cl10469
243231005491	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
243231005492	TPR motif; other site
243231005493	binding surface
243231005494	putative PEP-CTERM system TPR-repeat lipoprotein; Region: PEP_TPR_lipo; TIGR02917
243231005495	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
243231005496	binding surface
243231005497	TPR motif; other site
243231005498	Tetratricopeptide repeat; Region: TPR_16; pfam13432
243231005499	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
243231005500	binding surface
243231005501	TPR motif; other site
243231005502	Gram-negative bacterial tonB protein; Region: TonB; cl10048
243231005503	bifunctional malic enzyme oxidoreductase/phosphotransacetylase; Reviewed; Region: PRK07232
243231005504	Malic enzyme, N-terminal domain; Region: malic; pfam00390
243231005505	NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311
243231005506	putative NAD(P) binding site [chemical binding]; other site
243231005507	Phosphate acetyl/butaryl transferase; Region: PTA_PTB; cl00390
243231005508	FHIT (fragile histidine family): FHIT proteins, related to the HIT family carry a motif HxHxH/Qxx (x, is a hydrophobic amino acid), On the basis of sequence, substrate specificity, structure, evolution and mechanism, HIT proteins are classified into...; Region: FHIT; cd01275
243231005509	nucleotide binding site/active site [active]
243231005510	HIT family signature motif; other site
243231005511	catalytic residue [active]
243231005512	FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121
243231005513	Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to PFK family that includes ATP- and pyrophosphate (PPi)- dependent phosphofructokinases; Region: PFK; cl00204
243231005514	active site
243231005515	ADP/pyrophosphate binding site [chemical binding]; other site
243231005516	dimerization interface [polypeptide binding]; other site
243231005517	allosteric effector site; other site
243231005518	fructose-1,6-bisphosphate binding site; other site
243231005519	Sec8 exocyst complex component specific domain; Region: Sec8_exocyst; pfam04048
243231005520	GAF domain; Region: GAF_2; pfam13185
243231005521	GAF domain; Region: GAF; cl15785
243231005522	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
243231005523	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
243231005524	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
243231005525	dimer interface [polypeptide binding]; other site
243231005526	putative CheW interface [polypeptide binding]; other site
243231005527	Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557
243231005528	oligomerization interface [polypeptide binding]; other site
243231005529	active site
243231005530	metal binding site [ion binding]; metal-binding site
243231005531	pantoate--beta-alanine ligase; Region: panC; TIGR00018
243231005532	Pantoate-beta-alanine ligase; Region: PanC; cd00560
243231005533	active site
243231005534	ATP-binding site [chemical binding]; other site
243231005535	pantoate-binding site; other site
243231005536	HXXH motif; other site
243231005537	Glutamate decarboxylase and related PLP-dependent proteins [Amino acid transport and metabolism]; Region: GadB; COG0076
243231005538	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
243231005539	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
243231005540	catalytic residue [active]
243231005541	Cytosine deaminase and related metal-dependent hydrolases [Nucleotide transport and metabolism / General function prediction only]; Region: SsnA; COG0402
243231005542	Metallo-dependent hydrolases, subgroup D is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_D; cd01312
243231005543	active site
243231005544	Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294
243231005545	SmpB-tmRNA interface; other site
243231005546	Gsu5; element integrated into the tmRNA gene
243231005547	multiple promoter invertase; Provisional; Region: mpi; PRK13413
243231005548	Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768
243231005549	catalytic residues [active]
243231005550	catalytic nucleophile [active]
243231005551	Presynaptic Site I dimer interface [polypeptide binding]; other site
243231005552	Synaptic Antiparallel dimer interface [polypeptide binding]; other site
243231005553	Synaptic Flat tetramer interface [polypeptide binding]; other site
243231005554	Synaptic Site I dimer interface [polypeptide binding]; other site
243231005555	DNA binding site [nucleotide binding]
243231005556	AntA/AntB antirepressor; Region: AntA; cl01430
243231005557	BRO family, N-terminal domain; Region: Bro-N; cl10591
243231005558	This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713
243231005559	Active Sites [active]
243231005560	sulfate adenylyltransferase, small subunit; Region: CysD; TIGR02039
243231005561	This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713
243231005562	Active Sites [active]
243231005563	GTPases - Sulfate adenylate transferase subunit 1 [Inorganic ion transport and metabolism]; Region: CysN; COG2895
243231005564	CysN, together with protein CysD, forms the ATP sulfurylase (ATPS) complex; Region: CysN_ATPS; cd04166
243231005565	CysD dimerization site [polypeptide binding]; other site
243231005566	G1 box; other site
243231005567	putative GEF interaction site [polypeptide binding]; other site
243231005568	GTP/Mg2+ binding site [chemical binding]; other site
243231005569	Switch I region; other site
243231005570	G2 box; other site
243231005571	G3 box; other site
243231005572	Switch II region; other site
243231005573	G4 box; other site
243231005574	G5 box; other site
243231005575	CysN_NodQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NodQ_II; cd03695
243231005576	TCysN_NoDQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NoDQ_III; cd04095
243231005577	ParG; Region: ParG; pfam09274
243231005578	Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1),  6-pyrovoyl...; Region: TFold; cl00263
243231005579	active site
243231005580	Organic radical activating enzymes [Posttranslational modification, protein turnover, chaperones]; Region: NrdG; COG0602
243231005581	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
243231005582	FeS/SAM binding site; other site
243231005583	Creatinine amidohydrolase; Region: Creatininase; cl00618
243231005584	Mechanosensitive ion channel; Region: MS_channel; pfam00924
243231005585	Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840
243231005586	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
243231005587	active site
243231005588	metal binding site [ion binding]; metal-binding site
243231005589	DNA binding site [nucleotide binding]
243231005590	exonuclease subunit SbcD; Provisional; Region: PRK10966
243231005591	ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: SbcC; COG0419
243231005592	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
243231005593	Walker A/P-loop; other site
243231005594	ATP binding site [chemical binding]; other site
243231005595	chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168
243231005596	N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357
243231005597	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
243231005598	ABC transporter signature motif; other site
243231005599	Walker B; other site
243231005600	D-loop; other site
243231005601	H-loop/switch region; other site
243231005602	Prokaryotic dksA/traR C4-type zinc finger; Region: zf-dskA_traR; cl00755
243231005603	Pyruvate-formate lyase-activating enzyme [Posttranslational modification, protein turnover, chaperones]; Region: PflA; COG1180
243231005604	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
243231005605	FeS/SAM binding site; other site
243231005606	phenylacetate-CoA ligase; Region: PA_CoA_ligase; TIGR02155
243231005607	AMP-binding enzyme; Region: AMP-binding; cl15778
243231005608	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410
243231005609	LivF (TM1139) is part of the LIV-I bacterial ABC-type two-component transport system that imports neutral, branched-chain amino acids.  The  E. coli branched-chain amino acid transporter comprises a heterodimer of ABC transporters (LivF and LivG), a...; Region: ABC_TM1139_LivF_branched; cd03224
243231005610	Walker A/P-loop; other site
243231005611	ATP binding site [chemical binding]; other site
243231005612	Q-loop/lid; other site
243231005613	ABC transporter signature motif; other site
243231005614	Walker B; other site
243231005615	D-loop; other site
243231005616	H-loop/switch region; other site
243231005617	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411
243231005618	The Mj1267/LivG ABC transporter subfamily is involved in the transport of the hydrophobic amino acids leucine, isoleucine and valine.  MJ1267 is a branched-chain amino acid transporter with 29% similarity to both the LivF and LivG components of the E; Region: ABC_Mj1267_LivG_branched; cd03219
243231005619	Walker A/P-loop; other site
243231005620	ATP binding site [chemical binding]; other site
243231005621	Q-loop/lid; other site
243231005622	ABC transporter signature motif; other site
243231005623	Walker B; other site
243231005624	D-loop; other site
243231005625	H-loop/switch region; other site
243231005626	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
243231005627	TM-ABC transporter signature motif; other site
243231005628	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
243231005629	TM-ABC transporter signature motif; other site
243231005630	Periplasmic binding protein; Region: Peripla_BP_6; pfam13458
243231005631	Type I periplasmic binding component of ABC (ATPase Binding Cassette)-type transport systems that are predicted to be involved in uptake of amino acids; Region: PBP1_ABC-type_HAAT_like; cd06333
243231005632	putative ligand binding site [chemical binding]; other site
243231005633	ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683
243231005634	Type I periplasmic binding component of ABC (ATPase Binding Cassette)-type transport systems that are predicted to be involved in uptake of amino acids; Region: PBP1_ABC-type_HAAT_like; cd06333
243231005635	putative ligand binding site [chemical binding]; other site
243231005636	ACT domain-containing protein [General function prediction only]; Region: COG4747
243231005637	N-terminal ACT domain of a novel protein composed almost entirely of two tandem ACT domains; Region: ACT_Bt0572_1; cd04908
243231005638	C-terminal ACT domain of a novel protein composed of just two ACT domains; Region: ACT_Bt0572_2; cd04882
243231005639	AMP-binding enzyme; Region: AMP-binding; cl15778
243231005640	phenylacetate-CoA ligase; Region: PA_CoA_ligase; TIGR02155
243231005641	AMP-binding enzyme; Region: AMP-binding; cl15778
243231005642	Pyruvate ferredoxin/flavodoxin oxidoreductase; Region: POR; cl00546
243231005643	indolepyruvate ferredoxin oxidoreductase, alpha subunit; Region: IOR_alpha; TIGR03336
243231005644	Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034
243231005645	dimer interface [polypeptide binding]; other site
243231005646	PYR/PP interface [polypeptide binding]; other site
243231005647	TPP binding site [chemical binding]; other site
243231005648	substrate binding site [chemical binding]; other site
243231005649	Thiamine pyrophosphate (TPP) family, IOR-alpha subfamily, TPP-binding module; composed of proteins similar to indolepyruvate ferredoxin oxidoreductase (IOR) alpha subunit. IOR catalyzes the oxidative decarboxylation of arylpyruvates, such as...; Region: TPP_IOR_alpha; cd02008
243231005650	TPP-binding site; other site
243231005651	Ppx/GppA phosphatase family; Region: Ppx-GppA; cl15449
243231005652	Na+/phosphate symporter [Inorganic ion transport and metabolism]; Region: NptA; COG1283
243231005653	Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690
243231005654	Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690
243231005655	PhoU domain; Region: PhoU; pfam01895
243231005656	PhoU domain; Region: PhoU; pfam01895
243231005657	Protein of unknown function (DUF3187); Region: DUF3187; pfam11383
243231005658	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
243231005659	ligand binding site [chemical binding]; other site
243231005660	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
243231005661	IHF dimer interface [polypeptide binding]; other site
243231005662	IHF - DNA interface [nucleotide binding]; other site
243231005663	23S rRNA m(5)U1939 methyltransferase; Reviewed; Region: rumA; PRK13168
243231005664	TRAM domain; Region: TRAM; cl01282
243231005665	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
243231005666	S-adenosylmethionine binding site [chemical binding]; other site
243231005667	S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451
243231005668	rRNA binding site [nucleotide binding]; other site
243231005669	predicted 30S ribosome binding site; other site
243231005670	elongation factor P; Validated; Region: PRK00529
243231005671	Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207
243231005672	S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470
243231005673	RNA binding site [nucleotide binding]; other site
243231005674	S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794
243231005675	RNA binding site [nucleotide binding]; other site
243231005676	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it attaches...; Region: class_II_aaRS-like_core; cl00268
243231005677	EF-P lysine aminoacylase GenX; Region: genX; TIGR00462
243231005678	motif 1; other site
243231005679	dimer interface [polypeptide binding]; other site
243231005680	active site
243231005681	motif 2; other site
243231005682	motif 3; other site
243231005683	Lysine 2,3-aminomutase [Amino acid transport and metabolism]; Region: KamA; COG1509
243231005684	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cl15377
243231005685	dihydroorotate dehydrogenase (subfamily 1) family protein; Region: pyrD_sub1_fam; TIGR01037
243231005686	Dihydroorotate dehydrogenase (DHOD) class 1B FMN-binding domain. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine...; Region: DHOD_1B_like; cd04740
243231005687	heterodimer interface [polypeptide binding]; other site
243231005688	active site
243231005689	FMN binding site [chemical binding]; other site
243231005690	homodimer interface [polypeptide binding]; other site
243231005691	substrate binding site [chemical binding]; other site
243231005692	dihydroorotate dehydrogenase electron transfer subunit; Reviewed; Region: PRK00054
243231005693	FAD/NAD binding domain in the electron transfer subunit of dihydroorotate dehydrogenase. Dihydroorotate dehydrogenases (DHODs) catalyze the only redox reaction in pyrimidine de novo biosynthesis. They catalyze the oxidation of (S)-dihydroorotate to...; Region: DHOD_e_trans; cd06218
243231005694	FAD binding pocket [chemical binding]; other site
243231005695	FAD binding motif [chemical binding]; other site
243231005696	phosphate binding motif [ion binding]; other site
243231005697	beta-alpha-beta structure motif; other site
243231005698	NAD binding pocket [chemical binding]; other site
243231005699	Iron coordination center [ion binding]; other site
243231005700	ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575
243231005701	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
243231005702	Coenzyme A binding pocket [chemical binding]; other site
243231005703	phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385
243231005704	PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196
243231005705	dimerization interface [polypeptide binding]; other site
243231005706	putative ATP binding site [chemical binding]; other site
243231005707	phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647
243231005708	Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645
243231005709	active site
243231005710	substrate binding site [chemical binding]; other site
243231005711	cosubstrate binding site; other site
243231005712	catalytic site [active]
243231005713	Heme-binding domain of the class III cytochrome C family and related proteins; Region: Cytochrom_C3; cd08168
243231005714	heme-binding residues [chemical binding]; other site
243231005715	Cytochrome c; Region: Cytochrom_C; cl11414
243231005716	Cytochrome c; Region: Cytochrom_C; cl11414
243231005717	TPR repeat; Region: TPR_11; pfam13414
243231005718	TPR repeat; Region: TPR_11; pfam13414
243231005719	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
243231005720	TPR motif; other site
243231005721	binding surface
243231005722	TPR repeat; Region: TPR_11; pfam13414
243231005723	Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813
243231005724	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
243231005725	HSP70 interaction site [polypeptide binding]; other site
243231005726	1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444
243231005727	Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007
243231005728	TPP-binding site; other site
243231005729	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
243231005730	PYR/PP interface [polypeptide binding]; other site
243231005731	dimer interface [polypeptide binding]; other site
243231005732	TPP binding site [chemical binding]; other site
243231005733	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
243231005734	Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142
243231005735	Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685
243231005736	substrate binding pocket [chemical binding]; other site
243231005737	chain length determination region; other site
243231005738	substrate-Mg2+ binding site; other site
243231005739	catalytic residues [active]
243231005740	aspartate-rich region 1; other site
243231005741	active site lid residues [active]
243231005742	aspartate-rich region 2; other site
243231005743	Exonuclease VII small subunit; Region: Exonuc_VII_S; cl00750
243231005744	exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286
243231005745	ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489
243231005746	generic binding surface II; other site
243231005747	generic binding surface I; other site
243231005748	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
243231005749	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
243231005750	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
243231005751	Magnesium ion binding site [ion binding]; other site
243231005752	Putative catalytic domain of family 2 polysaccharide deacetylases (DACs) from bacteria; Region: CE4_DAC2; cd10936
243231005753	NodB motif; other site
243231005754	putative active site [active]
243231005755	putative catalytic site [active]
243231005756	Zn binding site [ion binding]; other site
243231005757	Type II cohesin domain, interaction partner of dockerin; Region: Type_II_cohesin; cd08547
243231005758	dockerin binding interface; other site
243231005759	prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK13108
243231005760	DNA-binding transcriptional activator of the SARP family [Signal transduction mechanisms]; Region: DnrI; COG3629
243231005761	C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526
243231005762	C-terminal peptidase (prc); Region: prc; TIGR00225
243231005763	PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988
243231005764	protein binding site [polypeptide binding]; other site
243231005765	C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560
243231005766	Catalytic dyad [active]
243231005767	Membrane-bound metallopeptidase [Cell division and chromosome partitioning]; Region: COG4942
243231005768	CRISPR/Cas system-associated protein Cas8b; Region: Cas8b_I-B; cl09718
243231005769	FtsX-like permease family; Region: FtsX; cl15850
243231005770	cell division ATP-binding protein FtsE; Region: FtsE; TIGR02673
243231005771	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
243231005772	Walker A/P-loop; other site
243231005773	ATP binding site [chemical binding]; other site
243231005774	Q-loop/lid; other site
243231005775	ABC transporter signature motif; other site
243231005776	Walker B; other site
243231005777	D-loop; other site
243231005778	H-loop/switch region; other site
243231005779	Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; cl06830
243231005780	Type II secretion system (T2SS), protein G; Region: T2SG; pfam08334
243231005781	Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulG; COG2165
243231005782	Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; cl06830
243231005783	TPR repeat; Region: TPR_11; pfam13414
243231005784	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
243231005785	binding surface
243231005786	TPR motif; other site
243231005787	TPR repeat; Region: TPR_11; pfam13414
243231005788	type IV pilus secretin (or competence protein) PilQ; Region: IV_pilus_PilQ; TIGR02515
243231005789	Secretin and TonB N terminus short domain; Region: STN; cl06624
243231005790	Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958
243231005791	Bacterial type II and III secretion system protein; Region: Secretin; pfam00263
243231005792	Cohesin domain, interaction parter of dockerin; Region: cohesin_like; cd08546
243231005793	dockerin binding interface; other site
243231005794	Fimbrial assembly protein (PilN); Region: PilN; pfam05137
243231005795	Tfp pilus assembly protein, ATPase PilM [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilM; COG4972
243231005796	type IV-A pilus assembly ATPase PilB; Region: type_IV_pilB; TIGR02538
243231005797	Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157
243231005798	PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129
243231005799	Walker A motif; other site
243231005800	ATP binding site [chemical binding]; other site
243231005801	Walker B motif; other site
243231005802	Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459
243231005803	Type II secretion system (T2SS), protein F; Region: T2SF; cl00906
243231005804	Type II secretion system (T2SS), protein F; Region: T2SF; cl00906
243231005805	decaheme c-type cytochrome, DmsE family; Region: decahem_SO; TIGR03508
243231005806	Uncharacterized conserved protein [Function unknown]; Region: COG3391
243231005807	NHL repeat; Region: NHL; pfam01436
243231005808	NHL repeat; Region: NHL; pfam01436
243231005809	NHL repeat; Region: NHL; pfam01436
243231005810	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
243231005811	DPM1_like represents putative enzymes similar to eukaryotic DPM1; Region: DPM1_like; cd06442
243231005812	Ligand binding site; other site
243231005813	Putative Catalytic site; other site
243231005814	DXD motif; other site
243231005815	ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466
243231005816	Found in ATP-dependent protease La (LON); Region: LON; smart00464
243231005817	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
243231005818	Walker A motif; other site
243231005819	ATP binding site [chemical binding]; other site
243231005820	Walker B motif; other site
243231005821	arginine finger; other site
243231005822	Subunit ChlI of Mg-chelatase; Region: ChlI; cl12214
243231005823	ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342
243231005824	ClpX C4-type zinc finger; Region: zf-C4_ClpX; cl05964
243231005825	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
243231005826	Walker A motif; other site
243231005827	ATP binding site [chemical binding]; other site
243231005828	Walker B motif; other site
243231005829	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; cl11083
243231005830	Clp protease; Region: CLP_protease; pfam00574
243231005831	Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017
243231005832	oligomer interface [polypeptide binding]; other site
243231005833	active site residues [active]
243231005834	trigger factor; Provisional; Region: tig; PRK01490
243231005835	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; cl11587
243231005836	Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698
243231005837	NTPase/HAM1.  This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515
243231005838	active site
243231005839	dimerization interface [polypeptide binding]; other site
243231005840	ribonuclease PH; Reviewed; Region: rph; PRK00173
243231005841	Ribonuclease PH; Region: RNase_PH_bact; cd11362
243231005842	hexamer interface [polypeptide binding]; other site
243231005843	active site
243231005844	DHH family; Region: DHH; pfam01368
243231005845	Helix-hairpin-helix motif; Region: HHH_3; pfam12836
243231005846	putative alpha-isopropylmalate/homocitrate synthase family transferase; Provisional; Region: PRK12344
243231005847	Desulfobacterium autotrophicum LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA3; cd07941
243231005848	active site
243231005849	catalytic residues [active]
243231005850	metal binding site [ion binding]; metal-binding site
243231005851	LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; cl07212
243231005852	aspartate kinase; Reviewed; Region: PRK06635
243231005853	AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261
243231005854	putative nucleotide binding site [chemical binding]; other site
243231005855	putative catalytic residues [active]
243231005856	putative Mg ion binding site [ion binding]; other site
243231005857	putative aspartate binding site [chemical binding]; other site
243231005858	ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913
243231005859	putative allosteric regulatory site; other site
243231005860	ACT domains of the lysine-sensitive, aspartokinase (AK) isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AKii-LysC-BS-like_2; cd04936
243231005861	putative allosteric regulatory residue; other site
243231005862	Uncharacterized P-loop hydrolase UPF0079; Region: UPF0079; cl00520
243231005863	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354
243231005864	YjeF-related protein N-terminus; Region: YjeF_N; cl00318
243231005865	putative carbohydrate kinase; Provisional; Region: PRK10565
243231005866	B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171
243231005867	putative substrate binding site [chemical binding]; other site
243231005868	putative ATP binding site [chemical binding]; other site
243231005869	4'-phosphopantetheinyl transferase superfamily; Region: ACPS; cl00500
243231005870	Pyridoxine 5'-phosphate (PNP) synthase domain; pyridoxal 5'-phosphate is the active form of vitamin B6 that acts as an essential, ubiquitous coenzyme in amino acid metabolism. In bacteria, formation of pyridoxine 5'-phosphate is a step in the...; Region: PNPsynthase; cd00003
243231005871	active site
243231005872	hydrophilic channel; other site
243231005873	dimerization interface [polypeptide binding]; other site
243231005874	catalytic residues [active]
243231005875	active site lid [active]
243231005876	phosphoglucosamine mutase; Provisional; Region: glmM; PRK14314
243231005877	GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802
243231005878	active site
243231005879	substrate binding site [chemical binding]; other site
243231005880	metal binding site [ion binding]; metal-binding site
243231005881	DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457
243231005882	dihydropteroate synthase; Region: DHPS; TIGR01496
243231005883	DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739
243231005884	substrate binding pocket [chemical binding]; other site
243231005885	dimer interface [polypeptide binding]; other site
243231005886	inhibitor binding site; inhibition site
243231005887	FtsH Extracellular; Region: FtsH_ext; pfam06480
243231005888	ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241
243231005889	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
243231005890	Walker A motif; other site
243231005891	ATP binding site [chemical binding]; other site
243231005892	Walker B motif; other site
243231005893	arginine finger; other site
243231005894	Peptidase family M41; Region: Peptidase_M41; pfam01434
243231005895	N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992
243231005896	B3/4 domain; Region: B3_4; cl11458
243231005897	Sporulation related domain; Region: SPOR; cl10051
243231005898	arginyl-tRNA synthetase; Reviewed; Region: argS; PRK01611
243231005899	Arginyl tRNA synthetase N terminal domain; Region: Arg_tRNA_synt_N; cl04104
243231005900	catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671
243231005901	active site
243231005902	HIGH motif; other site
243231005903	KMSK motif region; other site
243231005904	Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956
243231005905	tRNA binding surface [nucleotide binding]; other site
243231005906	anticodon binding site; other site
243231005907	Septum formation initiator; Region: DivIC; cl11433
243231005908	UDP-glucuronate decarboxylase (UGD) and related proteins, extended (e) SDRs; Region: UGD_SDR_e; cd05230
243231005909	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
243231005910	NAD binding site [chemical binding]; other site
243231005911	putative substrate binding site 2 [chemical binding]; other site
243231005912	putative substrate binding site 1 [chemical binding]; other site
243231005913	active site
243231005914	Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004
243231005915	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
243231005916	UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984
243231005917	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
243231005918	Outer membrane lipoprotein Slp family; Region: Slp; cl01164
243231005919	cofactor-independent phosphoglycerate mutase; Provisional; Region: PRK04200
243231005920	Sulfatase; Region: Sulfatase; cl10460
243231005921	XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798
243231005922	tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225
243231005923	active site
243231005924	Int/Topo IB signature motif; other site
243231005925	PII uridylyl-transferase; Provisional; Region: PRK05092
243231005926	Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401
243231005927	metal binding triad; other site
243231005928	GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335
243231005929	ACT domain family, ACT_UUR-like_1, includes the first of two C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_UUR-like_1; cd04900
243231005930	C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_ACR-UUR-like_2; cd04899
243231005931	AMIN domain; Region: AMIN; pfam11741
243231005932	N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696
243231005933	active site
243231005934	metal binding site [ion binding]; metal-binding site
243231005935	DNA mismatch repair protein MutS; Provisional; Region: PRK05399
243231005936	MutS domain I; Region: MutS_I; pfam01624
243231005937	MutS domain II; Region: MutS_II; pfam05188
243231005938	MutS family domain IV; Region: MutS_IV; pfam05190
243231005939	MutS1 homolog in eukaryotes.  The MutS protein initiates DNA mismatch repair by recognizing mispaired and unpaired bases embedded in duplex DNA and activating endo- and exonucleases to remove the mismatch.  Members of the MutS family possess C-terminal...; Region: ABC_MutS1; cd03284
243231005940	Walker A/P-loop; other site
243231005941	ATP binding site [chemical binding]; other site
243231005942	Q-loop/lid; other site
243231005943	ABC transporter signature motif; other site
243231005944	Walker B; other site
243231005945	D-loop; other site
243231005946	H-loop/switch region; other site
243231005947	CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453
243231005948	Domain of unknown function (DUF4124); Region: DUF4124; pfam13511
243231005949	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic 'goose-type' lysozymes (GEWL).  LTs catalyze...; Region: LT_GEWL; cd00254
243231005950	N-acetyl-D-glucosamine binding site [chemical binding]; other site
243231005951	catalytic residue [active]
243231005952	L-aspartate oxidase; Provisional; Region: PRK09077
243231005953	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
243231005954	Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910
243231005955	Chorismate mutase type II; Region: CM_2; cl00693
243231005956	3-deoxy-7-phosphoheptulonate synthase; Reviewed; Region: PRK08673
243231005957	Memo (mediator of ErbB2-driven cell motility) is co-precipitated with the C terminus of ErbB2, a protein involved in cell motility; Region: MEMO_like; cd07361
243231005958	putative ligand binding pocket/active site [active]
243231005959	putative metal binding site [ion binding]; other site
243231005960	Putative transcriptional regulators (Ypuh-like); Region: DUF387; cl00612
243231005961	ScpA/B protein; Region: ScpA_ScpB; cl00598
243231005962	tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282
243231005963	catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806
243231005964	active site
243231005965	HIGH motif; other site
243231005966	dimer interface [polypeptide binding]; other site
243231005967	KMSKS motif; other site
243231005968	Uncharacterized homologs of Site-2 protease (S2P), zinc metalloproteases (MEROPS family M50) which cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of the...; Region: S2P-M50_like_1; cd06158
243231005969	active site
243231005970	putative substrate binding region [chemical binding]; other site
243231005971	glutamine synthetase, type I; Region: GlnA; TIGR00653
243231005972	Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951
243231005973	Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120
243231005974	Nitrogen regulatory protein P-II; Region: P-II; cl00412
243231005975	Nitrogen regulatory protein P-II; Region: P-II; smart00938
243231005976	Domain of unknown function (DUF4124); Region: DUF4124; pfam13511
243231005977	Peptidase family M23; Region: Peptidase_M23; pfam01551
243231005978	ATP-dependent helicase HrpB; Region: DEAH_box_HrpB; TIGR01970
243231005979	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
243231005980	ATP binding site [chemical binding]; other site
243231005981	putative Mg++ binding site [ion binding]; other site
243231005982	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
243231005983	nucleotide binding region [chemical binding]; other site
243231005984	ATP-binding site [chemical binding]; other site
243231005985	Helicase associated domain (HA2); Region: HA2; cl04503
243231005986	ATP-dependent helicase C-terminal; Region: HrpB_C; pfam08482
243231005987	beta-phosphoglucomutase family hydrolase; Region: PGMB-YQAB-SF; TIGR02009
243231005988	Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391
243231005989	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
243231005990	motif II; other site
243231005991	PAP2_like_5 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_5; cd03394
243231005992	active site
243231005993	Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563
243231005994	polysaccharide export protein EpsE; Region: EpsE; TIGR03028
243231005995	SLBB domain; Region: SLBB; pfam10531
243231005996	SLBB domain; Region: SLBB; pfam10531
243231005997	polysaccharide export protein EpsE; Region: EpsE; TIGR03028
243231005998	SLBB domain; Region: SLBB; pfam10531
243231005999	SLBB domain; Region: SLBB; pfam10531
243231006000	Capsule biosynthesis GfcC; Region: Caps_synth_GfcC; pfam06251
243231006001	Predicted exonuclease of the beta-lactamase fold involved in RNA processing [Translation, ribosomal structure and biogenesis]; Region: YSH1; COG1236
243231006002	Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446
243231006003	Beta-Casp domain; Region: Beta-Casp; cl12567
243231006004	RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521
243231006005	Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as Transcription factor ImmunoGlobin (TIG) domains. They are present in intracellular transcription factors, cell surface receptors (such as plexins and scatter factor...; Region: IPT; cl15674
243231006006	Capsule assembly protein Wzi; Region: Caps_assemb_Wzi; pfam14052
243231006007	CoA-binding domain; Region: CoA_binding_3; pfam13727
243231006008	Bacterial sugar transferase; Region: Bac_transf; cl00939
243231006009	putative transposase OrfB; Reviewed; Region: PHA02517
243231006010	HTH-like domain; Region: HTH_21; pfam13276
243231006011	Integrase core domain; Region: rve; cl01316
243231006012	Integrase core domain; Region: rve_3; cl15866
243231006013	Undecaprenyl-phosphate glucose phosphotransferase; Region: WcaJ_sugtrans; TIGR03023
243231006014	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
243231006015	This family is most closely related to the GT1 family of glycosyltransferases. wbuB in E. coli is involved in the biosynthesis of the O26 O-antigen.  It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase; Region: GT1_wbuB_like; cd03794
243231006016	MatE; Region: MatE; cl10513
243231006017	UDP-N-acetyl-D-mannosamine dehydrogenase; Provisional; Region: wecC; PRK11064
243231006018	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
243231006019	UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984
243231006020	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
243231006021	Uncharacterized protein involved in exopolysaccharide biosynthesis [Cell envelope biogenesis, outer membrane]; Region: GumC; COG3206
243231006022	Chain length determinant protein; Region: Wzz; cl15801
243231006023	Chain length determinant protein; Region: Wzz; cl15801
243231006024	Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as Transcription factor ImmunoGlobin (TIG) domains. They are present in intracellular transcription factors, cell surface receptors (such as plexins and scatter factor...; Region: IPT; cl15674
243231006025	2-oxoglutarate ferredoxin oxidoreductase subunit gamma; Validated; Region: PRK08537
243231006026	Pyruvate ferredoxin/flavodoxin oxidoreductase; Region: POR; cl00546
243231006027	Thiamine pyrophosphate (TPP family), 2-oxoglutarate ferredoxin oxidoreductase (OGFOR) subfamily, TPP-binding module; OGFOR catalyzes the oxidative decarboxylation of 2-oxo-acids, with ferredoxin acting as an electron acceptor. In the TCA cycle, OGFOR...; Region: TPP_OGFOR; cd03375
243231006028	TPP-binding site [chemical binding]; other site
243231006029	2-ketoisovalerate ferredoxin reductase; Validated; Region: PRK07119
243231006030	Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034
243231006031	dimer interface [polypeptide binding]; other site
243231006032	PYR/PP interface [polypeptide binding]; other site
243231006033	TPP binding site [chemical binding]; other site
243231006034	substrate binding site [chemical binding]; other site
243231006035	4Fe-4S dicluster domain; Region: Fer4_10; pfam13237
243231006036	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
243231006037	ROS/MUCR transcriptional regulator protein; Region: ROS_MUCR; pfam05443
243231006038	Predicted transcriptional regulator [Transcription]; Region: COG4957
243231006039	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911
243231006040	UGMP family protein; Validated; Region: PRK09604
243231006041	Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl14000
243231006042	NYN ribonuclease and ATPase of PhoH family domains [General    function prediction only]; Region: COG1875
243231006043	PIN domain of bacterial Smg6-like homologs with PhoH-like ATPase domains; Region: PIN_PhoHL-ATPase; cd09883
243231006044	putative active site [active]
243231006045	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
243231006046	Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520
243231006047	Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453
243231006048	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
243231006049	catalytic residue [active]
243231006050	Periplasmic copper-binding protein (NosD); Region: NosD; pfam05048
243231006051	GAF domain; Region: GAF_2; pfam13185
243231006052	GAF domain; Region: GAF; cl15785
243231006053	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
243231006054	metal binding site [ion binding]; metal-binding site
243231006055	active site
243231006056	I-site; other site
243231006057	ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK08665
243231006058	Ribonucleotide reductase, all-alpha domain; Region: Ribonuc_red_lgN; pfam00317
243231006059	Class II ribonucleotide reductase, dimeric form; Region: RNR_II_dimer; cd02888
243231006060	active site
243231006061	dimer interface [polypeptide binding]; other site
243231006062	effector binding site; other site
243231006063	Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939
243231006064	TSCPD domain; Region: TSCPD; cl14834
243231006065	Domain of unknown function (DUF4410); Region: DUF4410; pfam14366
243231006066	oligoendopeptidase, pepF/M3 family; Region: M3_fam_3; TIGR02290
243231006067	Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_5; cd09610
243231006068	active site
243231006069	Zn binding site [ion binding]; other site
243231006070	outer membrane protein; Region: OMP_w_GlyGly; TIGR04219
243231006071	S-adenosyl-L-homocysteine hydrolase; Provisional; Region: PRK05476
243231006072	S-adenosyl-L-homocysteine hydrolase (AdoHycase) catalyzes the hydrolysis of S-adenosyl-L-homocysteine (AdoHyc) to form adenosine (Ado) and homocysteine (Hcy). The equilibrium lies far on the side of AdoHyc synthesis, but in nature the removal of Ado and...; Region: AdoHcyase; cd00401
243231006073	oligomerization interface [polypeptide binding]; other site
243231006074	active site
243231006075	NAD+ binding site [chemical binding]; other site
243231006076	Cache domain; Region: Cache_2; cl07034
243231006077	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4564
243231006078	Dioxygenases related to 2-nitropropane dioxygenase [General function prediction only]; Region: COG2070
243231006079	2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730
243231006080	FMN binding site [chemical binding]; other site
243231006081	substrate binding site [chemical binding]; other site
243231006082	putative catalytic residue [active]
243231006083	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920
243231006084	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
243231006085	dimer interface [polypeptide binding]; other site
243231006086	phosphorylation site [posttranslational modification]
243231006087	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
243231006088	ATP binding site [chemical binding]; other site
243231006089	Mg2+ binding site [ion binding]; other site
243231006090	G-X-G motif; other site
243231006091	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
243231006092	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
243231006093	active site
243231006094	phosphorylation site [posttranslational modification]
243231006095	intermolecular recognition site; other site
243231006096	dimerization interface [polypeptide binding]; other site
243231006097	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
243231006098	DNA binding site [nucleotide binding]
243231006099	S-adenosylmethionine synthetase; Validated; Region: PRK05250
243231006100	S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438
243231006101	S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772
243231006102	S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773
243231006103	Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080
243231006104	PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524
243231006105	PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; cl01586
243231006106	Pyruvate kinase (PK):  Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl09155
243231006107	Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367
243231006108	dimerization domain swap beta strand [polypeptide binding]; other site
243231006109	regulatory protein interface [polypeptide binding]; other site
243231006110	active site
243231006111	regulatory phosphorylation site [posttranslational modification]; other site
243231006112	PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006
243231006113	active pocket/dimerization site; other site
243231006114	active site
243231006115	phosphorylation site [posttranslational modification]
243231006116	P-loop ATPase protein family; Region: ATP_bind_2; cl15794
243231006117	Predicted P-loop-containing kinase [General function prediction only]; Region: COG1660
243231006118	HPr kinase/phosphorylase; Provisional; Region: PRK05428
243231006119	DRTGG domain; Region: DRTGG; cl12147
243231006120	HprK/P, the bifunctional histidine-containing protein kinase/phosphatase, controls the phosphorylation state of the phosphocarrier protein HPr and regulates the utilization of carbon sources by gram-positive bacteria. It catalyzes both the ATP-dependent...; Region: HprK_C; cd01918
243231006121	Hpr binding site; other site
243231006122	active site
243231006123	homohexamer subunit interaction site [polypeptide binding]; other site
243231006124	RaiA ('ribosome-associated inhibitor A', also known as Protein Y (PY), YfiA, and SpotY,  is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal A site; Region: RaiA; cd00552
243231006125	30S subunit binding site; other site
243231006126	RNA polymerase factor sigma-54; Reviewed; Region: PRK05932
243231006127	Sigma-54 factor, Activator interacting domain (AID); Region: Sigma54_AID; pfam00309
243231006128	Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963
243231006129	Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552
243231006130	ABC-type (unclassified) transport system, ATPase component [General function prediction only]; Region: YhbG; COG1137
243231006131	The ABC transporters belonging to the YhbG family are similar to members of the Mj1267_LivG family, which is involved in the transport of branched-chain amino acids. The genes yhbG and yhbN are located in a single operon and may function together in...; Region: ABC_YhbG; cd03218
243231006132	Walker A/P-loop; other site
243231006133	ATP binding site [chemical binding]; other site
243231006134	Q-loop/lid; other site
243231006135	ABC transporter signature motif; other site
243231006136	Walker B; other site
243231006137	D-loop; other site
243231006138	H-loop/switch region; other site
243231006139	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1934
243231006140	OstA-like protein; Region: OstA; cl00844
243231006141	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3117; cl01200
243231006142	Lipopolysaccharide-assembly, LptC-related; Region: LptC; pfam06835
243231006143	Response regulator containing a CheY-like receiver domain and an HD-GYP domain [Transcription / Signal transduction mechanisms]; Region: COG3437
243231006144	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
243231006145	active site
243231006146	phosphorylation site [posttranslational modification]
243231006147	intermolecular recognition site; other site
243231006148	dimerization interface [polypeptide binding]; other site
243231006149	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
243231006150	Zn2+ binding site [ion binding]; other site
243231006151	Mg2+ binding site [ion binding]; other site
243231006152	Low specificity phosphatase (HAD superfamily) [General function prediction only]; Region: COG1778
243231006153	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
243231006154	active site
243231006155	motif I; other site
243231006156	motif II; other site
243231006157	D-arabinose 5-phosphate isomerase; Provisional; Region: PRK10892
243231006158	KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014
243231006159	putative active site [active]
243231006160	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with KpsF/GutQ domains in the API [A5P (D-arabinose 5-phosphate) isomerase] protein.  These APIs catalyze the conversion of the pentose pathway...; Region: CBS_pair_KpsF_GutQ_assoc; cd04604
243231006161	NeuB family; Region: NeuB; cl00496
243231006162	CTP synthetase; Validated; Region: pyrG; PRK05380
243231006163	CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113
243231006164	Catalytic site [active]
243231006165	active site
243231006166	UTP binding site [chemical binding]; other site
243231006167	Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746
243231006168	active site
243231006169	putative oxyanion hole; other site
243231006170	catalytic triad [active]
243231006171	CMP-KDO synthetase catalyzes the activation of KDO which is an essential component of the lipopolysaccharide; Region: CMP-KDO-Synthetase; cd02517
243231006172	Ligand binding site; other site
243231006173	oligomer interface; other site
243231006174	Phosphorylase superfamily; Region: PNP_UDP_1; cl00303
243231006175	Protein of unknown function (DUF422); Region: DUF422; cl00991
243231006176	ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463
243231006177	mce related protein; Region: MCE; pfam02470
243231006178	Permease; Region: Permease; cl00510
243231006179	Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577
243231006180	substrate binding site [chemical binding]; other site
243231006181	3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402
243231006182	3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583
243231006183	substrate binding site [chemical binding]; other site
243231006184	ligand binding site [chemical binding]; other site
243231006185	Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695
243231006186	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box protein; Region: CSP_CDS; cd04458
243231006187	DNA-binding site [nucleotide binding]; DNA binding site
243231006188	RNA-binding motif; other site
243231006189	2-isopropylmalate synthase; Validated; Region: PRK00915
243231006190	2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940
243231006191	active site
243231006192	catalytic residues [active]
243231006193	metal binding site [ion binding]; metal-binding site
243231006194	LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; cl07212
243231006195	Phosphatidylserine synthase [Lipid metabolism]; Region: PssA; COG1183
243231006196	CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453
243231006197	Phosphatidylserine decarboxylase; Region: PS_Dcarbxylase; cl03656
243231006198	ketol-acid reductoisomerase; Provisional; Region: PRK05479
243231006199	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
243231006200	Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450
243231006201	acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895
243231006202	N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878
243231006203	putative valine binding site [chemical binding]; other site
243231006204	dimer interface [polypeptide binding]; other site
243231006205	Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369
243231006206	acetolactate synthase, large subunit, biosynthetic type; Region: acolac_lg; TIGR00118
243231006207	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
243231006208	PYR/PP interface [polypeptide binding]; other site
243231006209	dimer interface [polypeptide binding]; other site
243231006210	TPP binding site [chemical binding]; other site
243231006211	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; cl00815
243231006212	Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015
243231006213	TPP-binding site [chemical binding]; other site
243231006214	dimer interface [polypeptide binding]; other site
243231006215	Dehydratase family; Region: ILVD_EDD; cl00340
243231006216	Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl14000
243231006217	Predicted membrane-associated Zn-dependent proteases 1 [Cell envelope biogenesis, outer membrane]; Region: COG0750
243231006218	RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163
243231006219	active site
243231006220	PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989
243231006221	protein binding site [polypeptide binding]; other site
243231006222	Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020
243231006223	putative substrate binding region [chemical binding]; other site
243231006224	1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447
243231006225	1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670
243231006226	1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436
243231006227	DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288
243231006228	Cytidylyltransferase family; Region: CTP_transf_1; cl00347
243231006229	Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cl00230
243231006230	Putative undecaprenyl diphosphate synthase; Region: Prenyltransf; pfam01255
243231006231	catalytic residue [active]
243231006232	putative FPP diphosphate  binding site; other site
243231006233	putative FPP binding hydrophobic cleft; other site
243231006234	dimer interface [polypeptide binding]; other site
243231006235	putative IPP diphosphate binding site; other site
243231006236	ribosome recycling factor; Reviewed; Region: frr; PRK00083
243231006237	Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation.  Thus ribosomes are 'recycled' and ready for another round of...; Region: RRF; cd00520
243231006238	hinge region; other site
243231006239	UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254
243231006240	putative nucleotide binding site [chemical binding]; other site
243231006241	uridine monophosphate binding site [chemical binding]; other site
243231006242	homohexameric interface [polypeptide binding]; other site
243231006243	elongation factor Ts; Reviewed; Region: tsf; PRK12332
243231006244	Ubiquitin Associated domain. The UBA domain is a commonly occurring sequence motif in some members of the ubiquitination pathway, UV excision repair proteins, and certain protein kinases. Although its specific role is so far unknown, it has been...; Region: UBA; cl00153
243231006245	Elongation factor TS; Region: EF_TS; pfam00889
243231006246	Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425
243231006247	rRNA interaction site [nucleotide binding]; other site
243231006248	S8 interaction site; other site
243231006249	putative laminin-1 binding site; other site
243231006250	Predicted permeases [General function prediction only]; Region: COG0795; cl12074
243231006251	Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739
243231006252	Predicted permeases [General function prediction only]; Region: COG0795; cl12074
243231006253	Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739
243231006254	IPT domain (domain D) of cyclodextrin glycosyltransferase (CGTase) and similar enzymes. These enzymes are involved in the enzymatic hydrolysis of alpha-1,4 linkages of starch polymers and belong to the glycosyl hydrolase family 13. Most consist of three...; Region: IPT_CGTD; cd00604
243231006255	Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as Transcription factor ImmunoGlobin (TIG) domains. They are present in intracellular transcription factors, cell surface receptors (such as plexins and scatter factor...; Region: IPT; cl15674
243231006256	Cytidylate kinase-like family; Region: Cytidylate_kin2; pfam13189
243231006257	BON domain; Region: BON; cl02771
243231006258	Phospholipid methyltransferase; Region: PEMT; cl00763
243231006259	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
243231006260	Response regulator containing a CheY-like receiver domain and a GGDEF domain [Signal transduction mechanisms]; Region: PleD; COG3706
243231006261	active site
243231006262	phosphorylation site [posttranslational modification]
243231006263	intermolecular recognition site; other site
243231006264	dimerization interface [polypeptide binding]; other site
243231006265	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
243231006266	putative active site [active]
243231006267	heme pocket [chemical binding]; other site
243231006268	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
243231006269	metal binding site [ion binding]; metal-binding site
243231006270	active site
243231006271	I-site; other site
243231006272	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
243231006273	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054
243231006274	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
243231006275	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
243231006276	dimer interface [polypeptide binding]; other site
243231006277	phosphorylation site [posttranslational modification]
243231006278	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
243231006279	ATP binding site [chemical binding]; other site
243231006280	Mg2+ binding site [ion binding]; other site
243231006281	G-X-G motif; other site
243231006282	Response regulator receiver domain; Region: Response_reg; pfam00072
243231006283	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
243231006284	active site
243231006285	phosphorylation site [posttranslational modification]
243231006286	intermolecular recognition site; other site
243231006287	dimerization interface [polypeptide binding]; other site
243231006288	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088
243231006289	putative binding surface; other site
243231006290	active site
243231006291	Uncharacterized membrane protein [Function unknown]; Region: SapB; COG1285
243231006292	MgtC family; Region: MgtC; pfam02308
243231006293	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
243231006294	G1 box; other site
243231006295	GTP/Mg2+ binding site [chemical binding]; other site
243231006296	G2 box; other site
243231006297	Switch I region; other site
243231006298	G3 box; other site
243231006299	Switch II region; other site
243231006300	G4 box; other site
243231006301	G5 box; other site
243231006302	Sporulation related domain; Region: SPOR; cl10051
243231006303	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
243231006304	elongation factor G; Reviewed; Region: PRK12740
243231006305	G1 box; other site
243231006306	GTP/Mg2+ binding site [chemical binding]; other site
243231006307	G2 box; other site
243231006308	Switch I region; other site
243231006309	G3 box; other site
243231006310	Switch II region; other site
243231006311	G4 box; other site
243231006312	G5 box; other site
243231006313	EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088
243231006314	seadornavirus VP2 protein; Region: seadorna_VP2; TIGR04236
243231006315	EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434
243231006316	EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G.  Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713
243231006317	Type III pantothenate kinase; Region: Pan_kinase; cl09130
243231006318	bifunctional biotin--[acetyl-CoA-carboxylase] synthetase/biotin operon repressor; Provisional; Region: PRK11886
243231006319	Helix-turn-helix domains; Region: HTH; cl00088
243231006320	Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057
243231006321	Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237
243231006322	Nicotinate-nucleotide pyrophosphorylase [Coenzyme metabolism]; Region: NadC; COG0157
243231006323	Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572
243231006324	dimerization interface [polypeptide binding]; other site
243231006325	active site
243231006326	Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840
243231006327	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
243231006328	dimerization interface [polypeptide binding]; other site
243231006329	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
243231006330	metal binding site [ion binding]; metal-binding site
243231006331	active site
243231006332	I-site; other site
243231006333	Tetratricopeptide repeat; Region: TPR_6; pfam13174
243231006334	GAF domain; Region: GAF_2; pfam13185
243231006335	GAF domain; Region: GAF; cl15785
243231006336	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
243231006337	dimer interface [polypeptide binding]; other site
243231006338	phosphorylation site [posttranslational modification]
243231006339	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075
243231006340	GAF domain; Region: GAF; cl15785
243231006341	GAF domain; Region: GAF_2; pfam13185
243231006342	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
243231006343	Zn2+ binding site [ion binding]; other site
243231006344	Mg2+ binding site [ion binding]; other site
243231006345	PEP-CTERM-box response regulator transcription factor; Region: PEP_resp_reg; TIGR02915
243231006346	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
243231006347	active site
243231006348	phosphorylation site [posttranslational modification]
243231006349	intermolecular recognition site; other site
243231006350	dimerization interface [polypeptide binding]; other site
243231006351	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
243231006352	Walker A motif; other site
243231006353	ATP binding site [chemical binding]; other site
243231006354	Walker B motif; other site
243231006355	arginine finger; other site
243231006356	Helix-turn-helix domains; Region: HTH; cl00088
243231006357	putative PEP-CTERM system histidine kinase; Region: PEP_his_kin; TIGR02916
243231006358	GAF domain; Region: GAF; cl15785
243231006359	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
243231006360	ATP binding site [chemical binding]; other site
243231006361	G-X-G motif; other site
243231006362	Vi polysaccharide biosynthesis protein TviB; Provisional; Region: PRK15182
243231006363	UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984
243231006364	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
243231006365	PEP-CTERM motif; Region: VPEP; pfam07589
243231006366	Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754
243231006367	Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754
243231006368	Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754
243231006369	Coenzyme F390 synthetase [Coenzyme metabolism]; Region: PaaK; COG1541
243231006370	AMP-binding enzyme; Region: AMP-binding; cl15778
243231006371	Bacterial capsule synthesis protein PGA_cap; Region: PGA_cap; smart00854
243231006372	CapA and related proteins, metallophosphatase domain; Region: MPP_CapA; cd07381
243231006373	putative active site [active]
243231006374	putative metal binding site [ion binding]; other site
243231006375	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
243231006376	Asparagine synthase (glutamine-hydrolyzing) [Amino acid transport and metabolism]; Region: AsnB; COG0367
243231006377	Glutamine amidotransferases class-II (GATase) asparagine synthase_B type.  Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a  glutaminase domain and a...; Region: AsnB; cd00712
243231006378	active site
243231006379	dimer interface [polypeptide binding]; other site
243231006380	The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B  catalyzes the...; Region: Asn_Synthase_B_C; cd01991
243231006381	Ligand Binding Site [chemical binding]; other site
243231006382	Molecular Tunnel; other site
243231006383	O-Antigen ligase; Region: Wzy_C; cl04850
243231006384	Coenzyme F390 synthetase [Coenzyme metabolism]; Region: PaaK; COG1541
243231006385	AMP-binding enzyme; Region: AMP-binding; cl15778
243231006386	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
243231006387	N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357
243231006388	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
243231006389	This family is most closely related to the GT1 family of glycosyltransferases. WbnK in Shigella dysenteriae has been shown to be involved in the type 7 O-antigen biosynthesis; Region: GT1_WbnK_like; cd03807
243231006390	putative ADP-binding pocket [chemical binding]; other site
243231006391	poly-beta-1,6-N-acetyl-D-glucosamine N-deacetylase PgaB; Region: deacetyl_PgaB; TIGR03938
243231006392	Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692
243231006393	Putative catalytic NodB homology domain of PgaB, IcaB, and similar proteins which consist of a deformed (beta/alpha)8 barrel fold with 5- or 6-strands; Region: CE4_NodB_like_5s_6s; cd10918
243231006394	putative active site [active]
243231006395	putative metal binding site [ion binding]; other site
243231006396	N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357
243231006397	N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357
243231006398	serine O-acetyltransferase; Region: cysE; TIGR01172
243231006399	Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354
243231006400	trimer interface [polypeptide binding]; other site
243231006401	active site
243231006402	substrate binding site [chemical binding]; other site
243231006403	CoA binding site [chemical binding]; other site
243231006404	Predicted glycosyltransferases [General function prediction only]; Region: COG1216
243231006405	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
243231006406	active site
243231006407	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
243231006408	active site
243231006409	Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244
243231006410	MatE; Region: MatE; cl10513
243231006411	Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; cl09156
243231006412	M28 Zn-Peptidases; Region: M28_like_3; cd05644
243231006413	Domain of unknown function (DUF2172); Region: DUF2172; pfam09940
243231006414	active site
243231006415	metal binding site [ion binding]; metal-binding site
243231006416	OpgC protein; Region: OpgC_C; cl00792
243231006417	OpgC protein; Region: OpgC_C; cl00792
243231006418	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain associated with the NTP (Nucleotidyl transferase) domain downstream. CBS is a small domain originally identified in cystathionine beta-synthase and subsequently...; Region: CBS_pair_NTP_transferase_assoc; cd04607
243231006419	FOG: CBS domain [General function prediction only]; Region: COG0517
243231006420	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain associated with the NTP (Nucleotidyl transferase) domain downstream. CBS is a small domain originally identified in cystathionine beta-synthase and subsequently...; Region: CBS_pair_NTP_transferase_assoc; cd04607
243231006421	FOG: CBS domain [General function prediction only]; Region: COG0517
243231006422	NTP_trnasferase_like_2 is a member of the nucleotidyl transferase family; Region: NTP_transferase_like_2; cd06426
243231006423	Substrate binding site; other site
243231006424	metal-binding site
243231006425	N-acetylneuraminate synthase; Region: NeuB_NnaB; TIGR03569
243231006426	NeuB family; Region: NeuB; cl00496
243231006427	C-terminal SAF domain of sialic acid synthetase; Region: SAF_NeuB_like; cd11615
243231006428	NeuB binding interface [polypeptide binding]; other site
243231006429	putative substrate binding site [chemical binding]; other site
243231006430	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
243231006431	CMP-NeuAc_Synthase activates N-acetylneuraminic acid by adding CMP moiety; Region: CMP-NeuAc_Synthase; cd02513
243231006432	ligand binding site; other site
243231006433	tetramer interface; other site
243231006434	sugar O-acyltransferase, sialic acid O-acetyltransferase NeuD family; Region: NeuD_NnaD; TIGR03570
243231006435	Putative Acyltransferase (AT), Left-handed parallel beta-Helix (LbH) domain; This group is composed of mostly uncharacterized proteins containing an N-terminal helical subdomain followed by a LbH domain. The alignment contains 6 turns, each containing...; Region: LbH_AT_putative; cd03360
243231006436	putative trimer interface [polypeptide binding]; other site
243231006437	putative CoA binding site [chemical binding]; other site
243231006438	aminotransferase, LLPSF_NHT_00031 family; Region: NHT_00031; TIGR04181
243231006439	3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616
243231006440	inhibitor-cofactor binding pocket; inhibition site
243231006441	pyridoxal 5'-phosphate binding site [chemical binding]; other site
243231006442	catalytic residue [active]
243231006443	Arna decarboxylase_like, extended (e) SDRs; Region: Arna_like_SDR_e; cd05257
243231006444	NAD dependent epimerase/dehydratase, LLPSF_EDH_00030 family; Region: EDH_00030; TIGR04180
243231006445	NAD binding site [chemical binding]; other site
243231006446	substrate binding site [chemical binding]; other site
243231006447	active site
243231006448	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
243231006449	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
243231006450	CESA_like_1 is a member of the cellulose synthase (CESA) superfamily; Region: CESA_like_1; cd06439
243231006451	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
243231006452	DXD motif; other site
243231006453	Protein of unknown function (DUF3485); Region: DUF3485; cl11827
243231006454	Transmembrane exosortase (Exosortase_EpsH); Region: Exosortase_EpsH; pfam09721
243231006455	Predicted membrane protein [Function unknown]; Region: COG4083; cl15694
243231006456	Putative catalytic domain of uncharacterized prokaryotic polysaccharide deacetylases similar to bacterial PuuE allantoinases and Helicobacter pylori peptidoglycan deacetylase (HpPgdA); Region: CE4_PuuE_HpPgdA_like_2; cd10941
243231006457	putative active site [active]
243231006458	putative catalytic site [active]
243231006459	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl01155
243231006460	putative secretion ATPase, PEP-CTERM locus subfamily; Region: pepcterm_ATPase; TIGR03015
243231006461	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
243231006462	Walker A motif; other site
243231006463	ATP binding site [chemical binding]; other site
243231006464	Walker B motif; other site
243231006465	exopolysaccharide/PEPCTERM locus tyrosine autokinase; Region: pepcterm_TyrKin; TIGR03018
243231006466	This protein family consists of proteins similar to the cpaE protein of the Caulobacter pilus assembly and the orf4 protein of Actinobacillus pilus formation gene cluster. The function of these proteins are unkown. The Caulobacter pilus assembly contains...; Region: CpaE_like; cd03111
243231006467	Chain length determinant protein; Region: Wzz; cl15801
243231006468	polysaccharide chain length determinant protein, PEP-CTERM locus subfamily; Region: pepcterm_ChnLen; TIGR03007
243231006469	Chain length determinant protein; Region: Wzz; cl15801
243231006470	Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563
243231006471	putative polysaccharide export protein, PEP-CTERM sytem-associated; Region: pepcterm_export; TIGR03027
243231006472	putative polysaccharide export protein, PEP-CTERM sytem-associated; Region: pepcterm_export; TIGR03027
243231006473	SLBB domain; Region: SLBB; pfam10531
243231006474	sugar transferase, PEP-CTERM system associated; Region: EpsB_2; TIGR03013
243231006475	Bacterial sugar transferase; Region: Bac_transf; cl00939
243231006476	putative PEP-CTERM system TPR-repeat lipoprotein; Region: PEP_TPR_lipo; TIGR02917
243231006477	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
243231006478	binding surface
243231006479	TPR motif; other site
243231006480	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
243231006481	binding surface
243231006482	TPR motif; other site
243231006483	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
243231006484	binding surface
243231006485	TPR motif; other site
243231006486	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
243231006487	TPR motif; other site
243231006488	binding surface
243231006489	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
243231006490	binding surface
243231006491	TPR motif; other site
243231006492	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
243231006493	binding surface
243231006494	TPR motif; other site
243231006495	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
243231006496	binding surface
243231006497	TPR motif; other site
243231006498	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
243231006499	binding surface
243231006500	TPR motif; other site
243231006501	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
243231006502	binding surface
243231006503	TPR motif; other site
243231006504	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
243231006505	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
243231006506	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
243231006507	active site
243231006508	phosphorylation site [posttranslational modification]
243231006509	intermolecular recognition site; other site
243231006510	dimerization interface [polypeptide binding]; other site
243231006511	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
243231006512	Walker A motif; other site
243231006513	ATP binding site [chemical binding]; other site
243231006514	Walker B motif; other site
243231006515	arginine finger; other site
243231006516	Helix-turn-helix domains; Region: HTH; cl00088
243231006517	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
243231006518	dimer interface [polypeptide binding]; other site
243231006519	phosphorylation site [posttranslational modification]
243231006520	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
243231006521	ATP binding site [chemical binding]; other site
243231006522	Mg2+ binding site [ion binding]; other site
243231006523	G-X-G motif; other site
243231006524	CAAX protease self-immunity; Region: Abi; cl00558
243231006525	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
243231006526	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
243231006527	ligand binding site [chemical binding]; other site
243231006528	flexible hinge region; other site
243231006529	Helix-turn-helix domains; Region: HTH; cl00088
243231006530	Domain of unknown function (DUF4124); Region: DUF4124; pfam13511
243231006531	Intra-flagellar transport protein 57; Region: IFT57; pfam10498
243231006532	c(7)-type cytochrome triheme domain; Region: nanowire_3heme; TIGR04257
243231006533	c(7)-type cytochrome triheme domain; Region: nanowire_3heme; TIGR04257
243231006534	c(7)-type cytochrome triheme domain; Region: nanowire_3heme; TIGR04257
243231006535	c(7)-type cytochrome triheme domain; Region: nanowire_3heme; TIGR04257
243231006536	PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated; Region: PDZ; cl00117
243231006537	putative FeS-containing Cyanobacterial-specific oxidoreductase; Region: cyano_FeS_chp; TIGR03279
243231006538	Protein of unknown function (DUF512); Region: DUF512; pfam04459
243231006539	Domain of unknown function DUF20; Region: UPF0118; pfam01594
243231006540	pheromone autoinducer 2 transporter; Reviewed; Region: tqsA; cl00465
243231006541	The eukaryotic Sm and Sm-like (LSm) proteins associate with RNA to form the core domain of the ribonucleoprotein particles involved in a variety of RNA processing events including pre-mRNA splicing, telomere replication, and mRNA degradation.  Members of...; Region: Sm_like; cl00259
243231006542	Sm1 motif; other site
243231006543	D1 - D2 interaction site; other site
243231006544	D3 - B interaction site; other site
243231006545	Hfq - Hfq interaction site; other site
243231006546	RNA binding pocket [nucleotide binding]; other site
243231006547	Sm2 motif; other site
243231006548	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
243231006549	tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324
243231006550	DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095
243231006551	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075
243231006552	MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is...; Region: MutL_Trans; cd00782
243231006553	ATP binding site [chemical binding]; other site
243231006554	MutL C terminal dimerisation domain; Region: MutL_C; cl07336
243231006555	Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492
243231006556	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
243231006557	3-octaprenyl-4-hydroxybenzoate carboxy-lyase; Region: UbiD; cl00311
243231006558	Periplasmic binding protein; Region: Peripla_BP_6; pfam13458
243231006559	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
243231006560	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
243231006561	TM-ABC transporter signature motif; other site
243231006562	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
243231006563	TM-ABC transporter signature motif; other site
243231006564	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411
243231006565	The Mj1267/LivG ABC transporter subfamily is involved in the transport of the hydrophobic amino acids leucine, isoleucine and valine.  MJ1267 is a branched-chain amino acid transporter with 29% similarity to both the LivF and LivG components of the E; Region: ABC_Mj1267_LivG_branched; cd03219
243231006566	Walker A/P-loop; other site
243231006567	ATP binding site [chemical binding]; other site
243231006568	Q-loop/lid; other site
243231006569	ABC transporter signature motif; other site
243231006570	Walker B; other site
243231006571	D-loop; other site
243231006572	H-loop/switch region; other site
243231006573	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410
243231006574	LivF (TM1139) is part of the LIV-I bacterial ABC-type two-component transport system that imports neutral, branched-chain amino acids.  The  E. coli branched-chain amino acid transporter comprises a heterodimer of ABC transporters (LivF and LivG), a...; Region: ABC_TM1139_LivF_branched; cd03224
243231006575	Walker A/P-loop; other site
243231006576	ATP binding site [chemical binding]; other site
243231006577	Q-loop/lid; other site
243231006578	ABC transporter signature motif; other site
243231006579	Walker B; other site
243231006580	D-loop; other site
243231006581	H-loop/switch region; other site
243231006582	FOG: CBS domain [General function prediction only]; Region: COG0517
243231006583	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in  the acetoin utilization proteins in bacteria. Acetoin is a product of fermentative metabolism in many prokaryotic and eukaryotic microorganisms.  They produce...; Region: CBS_pair_ACT_assoc2; cd04585
243231006584	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
243231006585	cysteine desulfurase DndA; Region: DNA_S_dndA; TIGR03235
243231006586	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
243231006587	catalytic residue [active]
243231006588	Fe-S cluster assembly protein NifU; Region: NifU_proper; TIGR02000
243231006589	Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664
243231006590	trimerization site [polypeptide binding]; other site
243231006591	active site
243231006592	BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; cl01093
243231006593	NifU-like domain; Region: NifU; cl00484
243231006594	Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109
243231006595	This PGM-like (phosphoglucomutase-like) protein of unknown function belongs to the alpha-D-phosphohexomutase superfamily and is found in both archaea and bacteria. The alpha-D-phosphohexomutases include several related enzymes that catalyze a reversible...; Region: PGM_like2; cd05800
243231006596	active site
243231006597	substrate binding site [chemical binding]; other site
243231006598	metal binding site [ion binding]; metal-binding site
243231006599	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883
243231006600	nudix motif; other site
243231006601	PAS domain S-box; Region: sensory_box; TIGR00229
243231006602	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
243231006603	putative active site [active]
243231006604	heme pocket [chemical binding]; other site
243231006605	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
243231006606	metal binding site [ion binding]; metal-binding site
243231006607	active site
243231006608	I-site; other site
243231006609	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
243231006610	Predicted periplasmic solute-binding protein [General function prediction only]; Region: COG1427
243231006611	NMT1-like family; Region: NMT1_2; cl15260
243231006612	Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848
243231006613	lipoyl attachment site [posttranslational modification]; other site
243231006614	acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591
243231006615	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
243231006616	ATP-grasp domain; Region: ATP-grasp_4; cl03087
243231006617	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; cl08365
243231006618	acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302
243231006619	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
243231006620	carboxyltransferase (CT) interaction site; other site
243231006621	biotinylation site [posttranslational modification]; other site
243231006622	Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006
243231006623	Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321
243231006624	Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092
243231006625	active site
243231006626	Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466
243231006627	trimer interface [polypeptide binding]; other site
243231006628	active site
243231006629	dimer interface [polypeptide binding]; other site
243231006630	Roadblock/LC7 domain; Region: Robl_LC7; cl00886
243231006631	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
243231006632	TPR motif; other site
243231006633	binding surface
243231006634	Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195
243231006635	active site
243231006636	dimer interface [polypeptide binding]; other site
243231006637	metal binding site [ion binding]; metal-binding site
243231006638	shikimate kinase; Reviewed; Region: aroK; PRK00131
243231006639	Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464
243231006640	ADP binding site [chemical binding]; other site
243231006641	magnesium binding site [ion binding]; other site
243231006642	putative shikimate binding site; other site
243231006643	Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304
243231006644	Tetramer interface [polypeptide binding]; other site
243231006645	active site
243231006646	FMN-binding site [chemical binding]; other site
243231006647	AMIN domain; Region: AMIN; pfam11741
243231006648	AMIN domain; Region: AMIN; pfam11741
243231006649	type IV pilus secretin (or competence protein) PilQ; Region: IV_pilus_PilQ; TIGR02515
243231006650	Secretin and TonB N terminus short domain; Region: STN; cl06624
243231006651	Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958
243231006652	Bacterial type II and III secretion system protein; Region: Secretin; pfam00263
243231006653	Pilus assembly protein, PilP; Region: PilP; pfam04351
243231006654	Pilus assembly protein, PilO; Region: PilO; cl01234
243231006655	Tfp pilus assembly protein PilN [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilN; COG3166
243231006656	Fimbrial assembly protein (PilN); Region: PilN; pfam05137
243231006657	Competence protein A; Region: Competence_A; pfam11104
243231006658	Cell division protein FtsA; Region: FtsA; cl11496
243231006659	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
243231006660	non-specific DNA binding site [nucleotide binding]; other site
243231006661	salt bridge; other site
243231006662	sequence-specific DNA binding site [nucleotide binding]; other site
243231006663	3-ketosteroid-delta-1-dehydrogenase; Reviewed; Region: PRK12845
243231006664	Tfp pilus assembly protein, tip-associated adhesin PilY1 [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilY1; COG3419
243231006665	Neisseria PilC beta-propeller domain; Region: Neisseria_PilC; pfam05567
243231006666	Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459
243231006667	catalytic residues [active]
243231006668	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
243231006669	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
243231006670	active site
243231006671	phosphorylation site [posttranslational modification]
243231006672	intermolecular recognition site; other site
243231006673	dimerization interface [polypeptide binding]; other site
243231006674	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
243231006675	Walker A motif; other site
243231006676	ATP binding site [chemical binding]; other site
243231006677	Walker B motif; other site
243231006678	arginine finger; other site
243231006679	Helix-turn-helix domains; Region: HTH; cl00088
243231006680	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
243231006681	dimerization interface [polypeptide binding]; other site
243231006682	sensory histidine kinase AtoS; Provisional; Region: PRK11360
243231006683	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
243231006684	dimer interface [polypeptide binding]; other site
243231006685	phosphorylation site [posttranslational modification]
243231006686	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
243231006687	ATP binding site [chemical binding]; other site
243231006688	G-X-G motif; other site
243231006689	Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989
243231006690	Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750
243231006691	Type IV leader peptidase family; Region: Peptidase_A24; cl02077
243231006692	GAF domain; Region: GAF_2; pfam13185
243231006693	GAF domain; Region: GAF; cl15785
243231006694	PAS fold; Region: PAS_4; pfam08448
243231006695	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
243231006696	metal binding site [ion binding]; metal-binding site
243231006697	active site
243231006698	I-site; other site
243231006699	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
243231006700	valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729
243231006701	catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817
243231006702	HIGH motif; other site
243231006703	Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603
243231006704	catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817
243231006705	active site
243231006706	KMSKS motif; other site
243231006707	Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962
243231006708	tRNA binding surface [nucleotide binding]; other site
243231006709	anticodon binding site; other site
243231006710	Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458
243231006711	Response regulator receiver domain; Region: Response_reg; pfam00072
243231006712	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
243231006713	active site
243231006714	phosphorylation site [posttranslational modification]
243231006715	intermolecular recognition site; other site
243231006716	dimerization interface [polypeptide binding]; other site
243231006717	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
243231006718	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009
243231006719	Protein of unknown function (DUF2914); Region: DUF2914; pfam11141
243231006720	Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152
243231006721	heterotetramer interface [polypeptide binding]; other site
243231006722	active site pocket [active]
243231006723	cleavage site
243231006724	preprotein translocase subunit SecA; Reviewed; Region: PRK12904
243231006725	SecA preprotein cross-linking domain; Region: SecA_PP_bind; cl03078
243231006726	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
243231006727	nucleotide binding region [chemical binding]; other site
243231006728	Coenzyme F390 synthetase [Coenzyme metabolism]; Region: PaaK; COG1541
243231006729	AMP-binding enzyme; Region: AMP-binding; cl15778
243231006730	Pyruvate ferredoxin/flavodoxin oxidoreductase; Region: POR; cl00546
243231006731	indolepyruvate ferredoxin oxidoreductase, alpha subunit; Region: IOR_alpha; TIGR03336
243231006732	Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034
243231006733	dimer interface [polypeptide binding]; other site
243231006734	PYR/PP interface [polypeptide binding]; other site
243231006735	TPP binding site [chemical binding]; other site
243231006736	substrate binding site [chemical binding]; other site
243231006737	Thiamine pyrophosphate (TPP) family, IOR-alpha subfamily, TPP-binding module; composed of proteins similar to indolepyruvate ferredoxin oxidoreductase (IOR) alpha subunit. IOR catalyzes the oxidative decarboxylation of arylpyruvates, such as...; Region: TPP_IOR_alpha; cd02008
243231006738	TPP-binding site; other site
243231006739	4Fe-4S binding domain; Region: Fer4; cl02805
243231006740	TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638
243231006741	Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441
243231006742	Tripartite ATP-independent periplasmic transporters, DctQ component; Region: DctQ; cl01181
243231006743	DctM-like transporters; Region: DctM; pfam06808
243231006744	C4-dicarboxylate anaerobic carrier; Region: DcuC; cl15356
243231006745	Predicted inhibitor of MCP methylation, homolog of CheC [Cell motility and secretion]; Region: COG1406
243231006746	Chemotaxis phosphatase CheX; Region: CheX; cl15816
243231006747	Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; cl00398
243231006748	Putative modulator of DNA gyrase; Region: PmbA_TldD; pfam01523
243231006749	bifunctional argininosuccinate lyase/N-acetylglutamate synthase; Provisional; Region: PRK12308
243231006750	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
243231006751	Coenzyme A binding pocket [chemical binding]; other site
243231006752	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
243231006753	active site
243231006754	phosphorylation site [posttranslational modification]
243231006755	intermolecular recognition site; other site
243231006756	dimerization interface [polypeptide binding]; other site
243231006757	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
243231006758	metal binding site [ion binding]; metal-binding site
243231006759	active site
243231006760	I-site; other site
243231006761	HDOD domain; Region: HDOD; pfam08668
243231006762	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076
243231006763	ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497
243231006764	RecN ATPase involved in DNA repair; ABC (ATP-binding cassette) transporter nucleotide-binding domain; ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds including sugars, ions, peptides, and...; Region: ABC_RecN; cd03241
243231006765	Walker A/P-loop; other site
243231006766	ATP binding site [chemical binding]; other site
243231006767	Q-loop/lid; other site
243231006768	RecN ATPase involved in DNA repair; ABC (ATP-binding cassette) transporter nucleotide-binding domain; ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds including sugars, ions, peptides, and...; Region: ABC_RecN; cd03241
243231006769	ABC transporter signature motif; other site
243231006770	Walker B; other site
243231006771	D-loop; other site
243231006772	H-loop/switch region; other site
243231006773	Diacylglycerol kinase catalytic domain; Region: DAGK_cat; cl01255
243231006774	inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK03708
243231006775	This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300
243231006776	homodimer interface [polypeptide binding]; other site
243231006777	glycogen/starch/alpha-glucan phosphorylases; Region: P_ylase; TIGR02093
243231006778	active site pocket [active]
243231006779	recombination factor protein RarA; Reviewed; Region: PRK13342
243231006780	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
243231006781	Walker A motif; other site
243231006782	ATP binding site [chemical binding]; other site
243231006783	Walker B motif; other site
243231006784	arginine finger; other site
243231006785	MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002
243231006786	Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to PFK family that includes ATP- and pyrophosphate (PPi)- dependent phosphofructokinases; Region: PFK; cl00204
243231006787	active site
243231006788	ADP/pyrophosphate binding site [chemical binding]; other site
243231006789	dimerization interface [polypeptide binding]; other site
243231006790	allosteric effector site; other site
243231006791	fructose-1,6-bisphosphate binding site; other site
243231006792	Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637
243231006793	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
243231006794	motif II; other site
243231006795	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
243231006796	active site
243231006797	RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278
243231006798	RNA/DNA hybrid binding site [nucleotide binding]; other site
243231006799	active site
243231006800	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
243231006801	putative acyl-acceptor binding pocket; other site
243231006802	Dystroglycan-type cadherin-like domains; Region: CADG; smart00736
243231006803	Dystroglycan-type cadherin-like domains; Region: CADG; smart00736
243231006804	Cadherin repeat-like domain; Region: CA_like; cl15786
243231006805	Ca2+ binding site [ion binding]; other site
243231006806	Cadherin repeat-like domain; Region: CA_like; cl15786
243231006807	Dystroglycan-type cadherin-like domains; Region: CADG; smart00736
243231006808	Cadherin repeat-like domain; Region: CA_like; cl15786
243231006809	Dystroglycan-type cadherin-like domains; Region: CADG; smart00736
243231006810	Dystroglycan-type cadherin-like domains; Region: CADG; smart00736
243231006811	Cadherin repeat-like domain; Region: CA_like; cl15786
243231006812	Dystroglycan-type cadherin-like domains; Region: CADG; smart00736
243231006813	Dystroglycan-type cadherin-like domains; Region: CADG; smart00736
243231006814	peptidylprolyl isomerase; Provisional; Region: prsA; PRK00059
243231006815	PPIC-type PPIASE domain; Region: Rotamase; cl08278
243231006816	Peptidase inhibitor I9; Region: Inhibitor_I9; pfam05922
243231006817	type VII secretion-associated serine protease mycosin; Region: T7SS_mycosin; TIGR03921
243231006818	Peptidase S8 family domain in Subtilisin proteins; Region: Peptidases_S8_Subtilisin_subset; cd07477
243231006819	active site
243231006820	catalytic residues [active]
243231006821	Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as Transcription factor ImmunoGlobin (TIG) domains. They are present in intracellular transcription factors, cell surface receptors (such as plexins and scatter factor...; Region: IPT; cl15674
243231006822	Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511
243231006823	penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423
243231006824	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
243231006825	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009
243231006826	rod shape-determining protein MreD; Region: MreD; cl01087
243231006827	rod shape-determining protein MreC; Provisional; Region: PRK13922
243231006828	rod shape-determining protein MreC; Region: MreC; pfam04085
243231006829	Cupin domain; Region: Cupin_2; cl09118
243231006830	glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207
243231006831	G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538
243231006832	substrate binding site; other site
243231006833	tetramer interface; other site
243231006834	D,D-heptose 1,7-bisphosphate phosphatase; Validated; Region: PRK08942
243231006835	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
243231006836	active site
243231006837	motif I; other site
243231006838	motif II; other site
243231006839	ADP-heptose synthase, bifunctional sugar kinase/adenylyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaE; COG2870
243231006840	RfaE encodes a bifunctional ADP-heptose synthase involved in the biosynthesis of the lipopolysaccharide (LPS) core precursor ADP-L-glycero-D-manno-heptose. LPS plays an important role in maintaining the structural integrity of the bacterial outer...; Region: RfaE_like; cd01172
243231006841	putative ribose interaction site [chemical binding]; other site
243231006842	putative ADP binding site [chemical binding]; other site
243231006843	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
243231006844	active site
243231006845	nucleotide binding site [chemical binding]; other site
243231006846	HIGH motif; other site
243231006847	KMSKS motif; other site
243231006848	Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006
243231006849	dimer interface [polypeptide binding]; other site
243231006850	active site
243231006851	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
243231006852	active site
243231006853	rod shape-determining protein MreB; Provisional; Region: PRK13927
243231006854	Actin; An ubiquitous protein involved in the formation of filaments that are a major component of the cytoskeleton. Interaction with myosin provides the basis of muscular contraction and many aspects of cell motility. Each actin protomer binds one...; Region: ACTIN; cl11528
243231006855	ATP binding site [chemical binding]; other site
243231006856	profilin binding site; other site
243231006857	SurA N-terminal domain; Region: SurA_N_3; cl07813
243231006858	PPIC-type PPIASE domain; Region: Rotamase; cl08278
243231006859	non-metazoan 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_Sc; cd01414
243231006860	active site
243231006861	ATP binding site [chemical binding]; other site
243231006862	substrate binding site [chemical binding]; other site
243231006863	YaeQ protein; Region: YaeQ; cl01913
243231006864	ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488
243231006865	ABCF_EF-3  Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth.  EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221
243231006866	ABCF_EF-3  Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth.  EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221
243231006867	ABC transporter; Region: ABC_tran_2; pfam12848
243231006868	ABCF_EF-3  Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth.  EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221
243231006869	Response regulator containing a CheY-like receiver domain and an HD-GYP domain [Transcription / Signal transduction mechanisms]; Region: COG3437
243231006870	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
243231006871	active site
243231006872	phosphorylation site [posttranslational modification]
243231006873	intermolecular recognition site; other site
243231006874	dimerization interface [polypeptide binding]; other site
243231006875	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
243231006876	Zn2+ binding site [ion binding]; other site
243231006877	Mg2+ binding site [ion binding]; other site
243231006878	NAD(P)H-nitrite reductase [Energy production and conversion]; Region: NirB; COG1251
243231006879	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
243231006880	Fe-S-cluster-containing hydrogenase components 1 [Energy production and conversion]; Region: HybA; COG0437
243231006881	CO dehydrogenase maturation factor [Cell division and chromosome partitioning]; Region: CooC; COG3640
243231006882	The accessory protein CooC, which contains a nucleotide-binding domain (P-loop) near the N-terminus, participates in the maturation of the nickel center of carbon monoxide dehydrogenase (CODH). CODH from Rhodospirillum rubrum catalyzes the reversible...; Region: CooC; cd02034
243231006883	carbon-monoxide dehydrogenase, catalytic subunit; Region: CO_DH_cata; TIGR01702
243231006884	Carbon monoxide dehydrogenase (CODH) is found in acetogenic and methanogenic organisms and is responsible for the synthesis and breakdown of acetyl-CoA, respectively. CODH has two types of metal clusters, a cubane [Fe4-S4] center (B-cluster) similar to...; Region: CODH; cd01915
243231006885	ACS interaction site; other site
243231006886	CODH interaction site; other site
243231006887	cubane metal cluster (B-cluster) [ion binding]; other site
243231006888	Ni-Fe-S cluster (C-cluster) [ion binding]; other site
243231006889	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459
243231006890	PAS domain; Region: PAS_9; pfam13426
243231006891	putative active site [active]
243231006892	heme pocket [chemical binding]; other site
243231006893	LytTr DNA-binding domain; Region: LytTR; cl04498
243231006894	catalase/hydroperoxidase HPI(I); Provisional; Region: PRK15061
243231006895	N-terminal catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_1; cd00649
243231006896	dimer interface [polypeptide binding]; other site
243231006897	active site
243231006898	heme binding site [chemical binding]; other site
243231006899	C-terminal non-catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_2; cd08200
243231006900	glycyl radical enzyme, PFL2/glycerol dehydratase family; Region: PFL2-3; TIGR01774
243231006901	Pyruvate formate lyase 2 and related enzymes; Region: PFL2_DhaB_BssA; cd01677
243231006902	dimer interface [polypeptide binding]; other site
243231006903	active site
243231006904	glycine loop; other site
243231006905	glycyl-radical enzyme activating protein family; Region: PFLE_PFLC; TIGR02494
243231006906	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
243231006907	Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109
243231006908	Gsu21; element integrated into the tRNA-Gly-2 gene
243231006909	conserved hypothetical protein; Region: Lon_rel_chp; TIGR02653
243231006910	Putative ATP-dependent Lon protease; Region: Lon_2; cl11979
243231006911	Subunit ChlI of Mg-chelatase; Region: ChlI; cl12214
243231006912	TIGR02687 family protein; Region: TIGR02687
243231006913	PglZ domain; Region: PglZ; pfam08665
243231006914	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911
243231006915	N-6 DNA Methylase; Region: N6_Mtase; pfam02384
243231006916	Domain of unknown function (DUF1788); Region: DUF1788; pfam08747
243231006917	Putative inner membrane protein (DUF1819); Region: DUF1819; pfam08849
243231006918	Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600
243231006919	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
243231006920	active site
243231006921	DNA binding site [nucleotide binding]
243231006922	Int/Topo IB signature motif; other site
243231006923	element integrated into the tRNA-Gly-2 gene
243231006924	integrase; Provisional; Region: PRK09692
243231006925	Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements.  They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801
243231006926	active site
243231006927	Int/Topo IB signature motif; other site
243231006928	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
243231006929	IHF - DNA interface [nucleotide binding]; other site
243231006930	IHF dimer interface [polypeptide binding]; other site
243231006931	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic 'goose-type' lysozymes (GEWL).  LTs catalyze...; Region: LT_GEWL; cd00254
243231006932	N-acetyl-D-glucosamine binding site [chemical binding]; other site
243231006933	catalytic residue [active]
243231006934	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
243231006935	Walker A motif; other site
243231006936	ATP binding site [chemical binding]; other site
243231006937	AAA-like domain; Region: AAA_10; pfam12846
243231006938	Walker B motif; other site
243231006939	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
243231006940	catalytic residues [active]
243231006941	Conjugative relaxosome accessory transposon protein; Region: TraH; cl05580
243231006942	putative transposase OrfB; Reviewed; Region: PHA02517
243231006943	HTH-like domain; Region: HTH_21; pfam13276
243231006944	Integrase core domain; Region: rve; cl01316
243231006945	Integrase core domain; Region: rve_3; cl15866
243231006946	Nitrogen regulatory protein P-II; Region: P-II; cl00412
243231006947	Nitrogen regulatory protein P-II; Region: P-II; smart00938
243231006948	Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696
243231006949	Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404
243231006950	Membrane Fusion Protein cluster 2 (function with RND porters); Region: 8a0102; TIGR00999
243231006951	Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404
243231006952	Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538
243231006953	putative transposase OrfB; Reviewed; Region: PHA02517
243231006954	HTH-like domain; Region: HTH_21; pfam13276
243231006955	Integrase core domain; Region: rve; cl01316
243231006956	Integrase core domain; Region: rve_3; cl15866
243231006957	Domain of unknown function (DUF4372); Region: DUF4372; pfam14294
243231006958	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
243231006959	FOG: Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3385
243231006960	CpxP component of the bacterial Cpx-two-component system and related proteins; Region: CpxP_like; cl01482
243231006961	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
243231006962	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
243231006963	dimerization interface [polypeptide binding]; other site
243231006964	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
243231006965	dimer interface [polypeptide binding]; other site
243231006966	phosphorylation site [posttranslational modification]
243231006967	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
243231006968	ATP binding site [chemical binding]; other site
243231006969	Mg2+ binding site [ion binding]; other site
243231006970	G-X-G motif; other site
243231006971	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
243231006972	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
243231006973	active site
243231006974	phosphorylation site [posttranslational modification]
243231006975	intermolecular recognition site; other site
243231006976	dimerization interface [polypeptide binding]; other site
243231006977	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
243231006978	DNA binding site [nucleotide binding]
243231006979	Domain of unknown function DUF302; Region: DUF302; cl01364
243231006980	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217
243231006981	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
243231006982	metal-binding site [ion binding]
243231006983	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
243231006984	Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391
243231006985	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
243231006986	dimerization interface [polypeptide binding]; other site
243231006987	putative DNA binding site [nucleotide binding]; other site
243231006988	putative Zn2+ binding site [ion binding]; other site
243231006989	SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496
243231006990	dimer interface [polypeptide binding]; other site
243231006991	ssDNA binding site [nucleotide binding]; other site
243231006992	tetramer (dimer of dimers) interface [polypeptide binding]; other site
243231006993	TSCPD domain; Region: TSCPD; cl14834
243231006994	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
243231006995	Walker A motif; other site
243231006996	ATP binding site [chemical binding]; other site
243231006997	Walker B motif; other site
243231006998	CbbQ/NirQ/NorQ C-terminal; Region: CbbQ_C; pfam08406
243231006999	WGR domain of bacterial DNA ligases; Region: WGR_DNA_ligase; cd07998
243231007000	Protein of unknown function (DUF3150); Region: DUF3150; pfam11348
243231007001	Cobalamin biosynthesis protein CobT (nicotinate-mononucleotide:5, 6-dimethylbenzimidazole phosphoribosyltransferase) [Coenzyme metabolism]; Region: CobT; COG4547
243231007002	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057
243231007003	metal ion-dependent adhesion site (MIDAS); other site
243231007004	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911
243231007005	Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: HsdR; COG4096
243231007006	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
243231007007	CHC2 zinc finger; Region: zf-CHC2; cl15369
243231007008	Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071
243231007009	MPN+ (JAMM) motif; other site
243231007010	Zinc-binding site [ion binding]; other site
243231007011	putative transposase OrfB; Reviewed; Region: PHA02517
243231007012	HTH-like domain; Region: HTH_21; pfam13276
243231007013	Integrase core domain; Region: rve; cl01316
243231007014	Integrase core domain; Region: rve_3; cl15866
243231007015	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
243231007016	ligand binding site [chemical binding]; other site
243231007017	Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600
243231007018	TrfA protein; Region: TrfA; pfam07042
243231007019	Replication initiator protein A; Region: RPA; cl02339
243231007020	RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
243231007021	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
243231007022	DNA binding residues [nucleotide binding]
243231007023	Domain of unknown function (DUF4372); Region: DUF4372; pfam14294
243231007024	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
243231007025	FOG: Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3385
243231007026	plasmid segregation protein ParM; Provisional; Region: PRK13917
243231007027	Domain of unknown function (DUF4095); Region: DUF4095; pfam13338
243231007028	Fic/DOC family; Region: Fic; cl00960
243231007029	Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398
243231007030	tRNA nucleotidyltransferase/poly(A) polymerase [Translation, ribosomal structure and biogenesis]; Region: PcnB; COG0617
243231007031	active site
243231007032	NTP binding site [chemical binding]; other site
243231007033	metal binding triad [ion binding]; metal-binding site
243231007034	Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627
243231007035	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076
243231007036	Anti-sigma-28 factor, FlgM; Region: FlgM; cl01052
243231007037	Hydroxyneurosporene synthase (CrtC); Region: CrtC; cl12101
243231007038	FtsX-like permease family; Region: FtsX; cl15850
243231007039	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
243231007040	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
243231007041	This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE).  They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255
243231007042	Walker A/P-loop; other site
243231007043	ATP binding site [chemical binding]; other site
243231007044	Q-loop/lid; other site
243231007045	ABC transporter signature motif; other site
243231007046	Walker B; other site
243231007047	D-loop; other site
243231007048	H-loop/switch region; other site
243231007049	PAS fold; Region: PAS_4; pfam08448
243231007050	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
243231007051	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
243231007052	ATP binding site [chemical binding]; other site
243231007053	Mg2+ binding site [ion binding]; other site
243231007054	G-X-G motif; other site
243231007055	Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cl00214
243231007056	Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cl00214
243231007057	Aldehyde:ferredoxin oxidoreductase [Energy production and conversion]; Region: COG2414
243231007058	Aldehyde ferredoxin oxidoreductase, N-terminal domain; Region: AFOR_N; cl08354
243231007059	Aldehyde ferredoxin oxidoreductase, domains 2 & 3; Region: AFOR_C; pfam01314
243231007060	phosphoglycolate phosphatase; Provisional; Region: PRK13222
243231007061	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
243231007062	motif II; other site
243231007063	Uncharacterized family of ferritin-like proteins found in archaea and bacteria; Region: Ferritin_like_AB; cd01045
243231007064	diiron binding motif [ion binding]; other site
243231007065	GMP synthase; Reviewed; Region: guaA; PRK00074
243231007066	Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742
243231007067	AMP/PPi binding site [chemical binding]; other site
243231007068	candidate oxyanion hole; other site
243231007069	catalytic triad [active]
243231007070	potential glutamine specificity residues [chemical binding]; other site
243231007071	The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997
243231007072	ATP Binding subdomain [chemical binding]; other site
243231007073	Ligand Binding sites [chemical binding]; other site
243231007074	Dimerization subdomain; other site
243231007075	inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567
243231007076	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl09108
243231007077	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a key...; Region: CBS_pair_IMPDH; cd04601
243231007078	IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of the guanine...; Region: IMPDH; cd00381
243231007079	active site
243231007080	Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363
243231007081	M42 Peptidase, Endoglucanases; Region: M42_Frv; cd05656
243231007082	oligomer interface [polypeptide binding]; other site
243231007083	active site
243231007084	metal binding site [ion binding]; metal-binding site
243231007085	Bifunctional nuclease; Region: DNase-RNase; cl00553
243231007086	(dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14325
243231007087	Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919
243231007088	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
243231007089	FeS/SAM binding site; other site
243231007090	TRAM domain; Region: TRAM; cl01282
243231007091	Protein of unknown function (DUF3373); Region: DUF3373; pfam11853
243231007092	Prefoldin is a hexameric molecular chaperone complex, found in both eukaryotes and archaea, that binds and stabilizes newly synthesized polypeptides allowing them to fold correctly.  The complex contains two alpha and four beta subunits, the two subunits...; Region: Prefoldin; cl09111
243231007093	Cytochrome c554 and c-prime; Region: Cytochrome_C554; pfam13435
243231007094	decaheme c-type cytochrome, DmsE family; Region: decahem_SO; TIGR03508
243231007095	Heme-binding domain of the class III cytochrome C family and related proteins; Region: Cytochrom_C3; cl03439
243231007096	heme-binding residues [chemical binding]; other site
243231007097	Cytochrome c bacterial; Region: Cytochrome_cB; pfam11783
243231007098	Transcriptional regulator [Transcription]; Region: LysR; COG0583
243231007099	Helix-turn-helix domains; Region: HTH; cl00088
243231007100	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
243231007101	dimerization interface [polypeptide binding]; other site
243231007102	decaheme c-type cytochrome, DmsE family; Region: decahem_SO; TIGR03508
243231007103	Doubled CXXCH motif (Paired_CXXCH_1); Region: Paired_CXXCH_1; cl09905
243231007104	Doubled CXXCH motif (Paired_CXXCH_1); Region: Paired_CXXCH_1; cl09905
243231007105	Doubled CXXCH motif (Paired_CXXCH_1); Region: Paired_CXXCH_1; cl09905
243231007106	Protein of unknown function (DUF3374); Region: DUF3374; cl11904
243231007107	Ribosomal protein S20; Region: Ribosomal_S20p; cl00384
243231007108	DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144
243231007109	DNA polymerase III, delta subunit; Region: holA; TIGR01128
243231007110	Lipopolysaccharide-assembly; Region: LptE; cl01125
243231007111	leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390
243231007112	catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812
243231007113	HIGH motif; other site
243231007114	Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603
243231007115	catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812
243231007116	active site
243231007117	KMSKS motif; other site
243231007118	Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958
243231007119	tRNA binding surface [nucleotide binding]; other site
243231007120	c(7)-type cytochrome triheme domain; Region: nanowire_3heme; TIGR04257
243231007121	c(7)-type cytochrome triheme domain; Region: nanowire_3heme; TIGR04257
243231007122	c(7)-type cytochrome triheme domain; Region: nanowire_3heme; TIGR04257
243231007123	c(7)-type cytochrome triheme domain; Region: nanowire_3heme; TIGR04257
243231007124	c(7)-type cytochrome triheme domain; Region: nanowire_3heme; TIGR04257
243231007125	c(7)-type cytochrome triheme domain; Region: nanowire_3heme; TIGR04257
243231007126	c(7)-type cytochrome triheme domain; Region: nanowire_3heme; TIGR04257
243231007127	c(7)-type cytochrome triheme domain; Region: nanowire_3heme; TIGR04257
243231007128	c(7)-type cytochrome triheme domain; Region: nanowire_3heme; TIGR04257
243231007129	Response regulator receiver domain; Region: Response_reg; pfam00072
243231007130	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
243231007131	active site
243231007132	phosphorylation site [posttranslational modification]
243231007133	intermolecular recognition site; other site
243231007134	dimerization interface [polypeptide binding]; other site
243231007135	GAF domain; Region: GAF_2; pfam13185
243231007136	GAF domain; Region: GAF; cl15785
243231007137	chemotaxis-specific methylesterase; Provisional; Region: PRK00742
243231007138	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
243231007139	active site
243231007140	phosphorylation site [posttranslational modification]
243231007141	intermolecular recognition site; other site
243231007142	dimerization interface [polypeptide binding]; other site
243231007143	CheB methylesterase; Region: CheB_methylest; pfam01339
243231007144	CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705
243231007145	Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352
243231007146	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911
243231007147	FOG: HEAT repeat [Energy production and conversion]; Region: COG1413
243231007148	FOG: HEAT repeat [Energy production and conversion]; Region: COG1413
243231007149	FOG: HEAT repeat [Energy production and conversion]; Region: COG1413
243231007150	zinc-ribbon domain; Region: zinc_ribbon_5; cl11777
243231007151	Response regulator receiver domain; Region: Response_reg; pfam00072
243231007152	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
243231007153	active site
243231007154	phosphorylation site [posttranslational modification]
243231007155	intermolecular recognition site; other site
243231007156	dimerization interface [polypeptide binding]; other site
243231007157	CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256
243231007158	Response regulator receiver domain; Region: Response_reg; pfam00072
243231007159	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
243231007160	active site
243231007161	phosphorylation site [posttranslational modification]
243231007162	intermolecular recognition site; other site
243231007163	dimerization interface [polypeptide binding]; other site
243231007164	CheW, a small regulator protein, unique to the chemotaxis signalling in prokaryotes and archea. CheW interacts with the histidine kinase CheA, most likely with the related regulatory domain of CheA. CheW is proposed to form signalling arrays together...; Region: CheW; cd00732
243231007165	putative CheA interaction surface; other site
243231007166	putative secretion ATPase, PEP-CTERM locus subfamily; Region: pepcterm_ATPase; TIGR03015
243231007167	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
243231007168	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088
243231007169	Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643
243231007170	putative binding surface; other site
243231007171	active site
243231007172	Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895
243231007173	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
243231007174	ATP binding site [chemical binding]; other site
243231007175	Mg2+ binding site [ion binding]; other site
243231007176	G-X-G motif; other site
243231007177	CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731
243231007178	Response regulator receiver domain; Region: Response_reg; pfam00072
243231007179	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
243231007180	active site
243231007181	phosphorylation site [posttranslational modification]
243231007182	intermolecular recognition site; other site
243231007183	dimerization interface [polypeptide binding]; other site
243231007184	Domain of unknown function (DUF4388); Region: DUF4388; pfam14332
243231007185	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
243231007186	active site
243231007187	phosphorylation site [posttranslational modification]
243231007188	intermolecular recognition site; other site
243231007189	dimerization interface [polypeptide binding]; other site
243231007190	GTP-binding protein Der; Reviewed; Region: PRK00093
243231007191	EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894
243231007192	G1 box; other site
243231007193	GTP/Mg2+ binding site [chemical binding]; other site
243231007194	Switch I region; other site
243231007195	G2 box; other site
243231007196	Switch II region; other site
243231007197	G3 box; other site
243231007198	G4 box; other site
243231007199	G5 box; other site
243231007200	EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895
243231007201	G1 box; other site
243231007202	GTP/Mg2+ binding site [chemical binding]; other site
243231007203	Switch I region; other site
243231007204	G2 box; other site
243231007205	G3 box; other site
243231007206	Switch II region; other site
243231007207	G4 box; other site
243231007208	G5 box; other site
243231007209	GTPase Era; Reviewed; Region: era; PRK00089
243231007210	E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163
243231007211	G1 box; other site
243231007212	GTP/Mg2+ binding site [chemical binding]; other site
243231007213	Switch I region; other site
243231007214	G2 box; other site
243231007215	Switch II region; other site
243231007216	G3 box; other site
243231007217	G4 box; other site
243231007218	G5 box; other site
243231007219	KH-II  (K homology RNA-binding domain, type II). KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins  (e.g. ribosomal protein S3), transcription factors (e.g. NusA_K), and post-transcriptional...; Region: KH-II; cl00098
243231007220	Elongator protein 3, MiaB family, Radical SAM; Region: Elp3; smart00729
243231007221	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
243231007222	FeS/SAM binding site; other site
243231007223	ribonuclease III; Reviewed; Region: rnc; PRK00102
243231007224	RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593
243231007225	dimerization interface [polypeptide binding]; other site
243231007226	active site
243231007227	metal binding site [ion binding]; metal-binding site
243231007228	Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048
243231007229	dsRNA binding site [nucleotide binding]; other site
243231007230	thymidylate kinase; Validated; Region: tmk; PRK00698
243231007231	Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672
243231007232	TMP-binding site; other site
243231007233	ATP-binding site [chemical binding]; other site
243231007234	DNA polymerase III, delta subunit; Region: DNA_pol3_delta2; pfam13177
243231007235	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
243231007236	DNA polymerase III subunit delta'; Validated; Region: PRK07940
243231007237	PSP1 C-terminal conserved region; Region: PSP1; cl00770
243231007238	methionyl-tRNA synthetase; Reviewed; Region: PRK11893
243231007239	catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814
243231007240	active site
243231007241	HIGH motif; other site
243231007242	KMSKS motif; other site
243231007243	Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957
243231007244	tRNA binding surface [nucleotide binding]; other site
243231007245	anticodon binding site; other site
243231007246	YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259
243231007247	putative active site [active]
243231007248	Ribosomal L28 family; Region: Ribosomal_L28; cl00367
243231007249	YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448
243231007250	homotrimer interaction site [polypeptide binding]; other site
243231007251	putative active site [active]
243231007252	Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317
243231007253	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076
243231007254	Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399
243231007255	synthetase active site [active]
243231007256	NTP binding site [chemical binding]; other site
243231007257	metal binding site [ion binding]; metal-binding site
243231007258	TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668
243231007259	ACT  domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876
243231007260	RNA polymerase Rpb6; Region: RNA_pol_Rpb6; cl14651
243231007261	Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194
243231007262	Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071
243231007263	catalytic site [active]
243231007264	G-X2-G-X-G-K; other site
243231007265	hypothetical protein; Provisional; Region: PRK11820
243231007266	YicC-like family, N-terminal region; Region: YicC_N; pfam03755
243231007267	Domain of unknown function (DUF1732); Region: DUF1732; pfam08340
243231007268	UDP-glucose-4-epimerase; Region: galE; TIGR01179
243231007269	UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247
243231007270	NAD binding site [chemical binding]; other site
243231007271	homodimer interface [polypeptide binding]; other site
243231007272	active site
243231007273	substrate binding site [chemical binding]; other site
243231007274	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
243231007275	UDP glucuronic acid epimerase, extended (e) SDRs; Region: UDP_GE_SDE_e; cd05253
243231007276	putative NAD(P) binding site [chemical binding]; other site
243231007277	active site
243231007278	putative substrate binding site [chemical binding]; other site
243231007279	ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859
243231007280	Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789
243231007281	putative active site [active]
243231007282	UDP-N-acetylglucosamine 2-epimerase; Region: wecB; TIGR00236
243231007283	Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase  family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786
243231007284	active site
243231007285	homodimer interface [polypeptide binding]; other site
243231007286	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
243231007287	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
243231007288	active site
243231007289	UDP-N-acetylglucosamine 2-epimerase [Cell envelope biogenesis, outer membrane]; Region: WecB; COG0381
243231007290	Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase  family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786
243231007291	active site
243231007292	homodimer interface [polypeptide binding]; other site
243231007293	UDP-N-acetylglucosamine 4,6-dehydratase/5-epimerase; Region: FnlA; TIGR04130
243231007294	UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237
243231007295	NAD(P) binding site [chemical binding]; other site
243231007296	homodimer interface [polypeptide binding]; other site
243231007297	substrate binding site [chemical binding]; other site
243231007298	active site
243231007299	Polysaccharide biosynthesis protein C-terminal; Region: Polysacc_syn_2C; pfam08485
243231007300	dTDP-4-dehydrorhamnose reductase [Cell envelope biogenesis, outer membrane]; Region: RfbD; COG1091
243231007301	dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254
243231007302	NADP binding site [chemical binding]; other site
243231007303	active site
243231007304	putative substrate binding site [chemical binding]; other site
243231007305	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911
243231007306	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
243231007307	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
243231007308	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
243231007309	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
243231007310	Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789
243231007311	putative active site [active]
243231007312	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
243231007313	Glycosyltransferase Family 4; Region: Glyco_transf_4; pfam13439
243231007314	UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511
243231007315	putative metal binding site; other site
243231007316	GDP-fucose protein O-fucosyltransferase and related proteins; Region: O-FucT_like; cl16914
243231007317	GDP-Fucose binding site [chemical binding]; other site
243231007318	Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789
243231007319	ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859
243231007320	putative active site [active]
243231007321	Trm112p-like protein; Region: Trm112p; cl01066
243231007322	Tetraacyldisaccharide-1-P 4'-kinase; Region: LpxK; cl03652
243231007323	tetraacyldisaccharide 4'-kinase; Region: lpxK; TIGR00682
243231007324	3-deoxy-D-manno-octulosonic-acid transferase; Reviewed; Region: PRK05749
243231007325	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
243231007326	lipid A export permease/ATP-binding protein MsbA; Region: MsbA_lipidA; TIGR02203
243231007327	ABC transporter transmembrane region; Region: ABC_membrane; cl00549
243231007328	MsbA is an essential ABC transporter, closely related to eukaryotic MDR proteins.  ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars, ions, peptides, and more complex organic...; Region: ABCC_MsbA; cd03251
243231007329	Walker A/P-loop; other site
243231007330	ATP binding site [chemical binding]; other site
243231007331	Q-loop/lid; other site
243231007332	ABC transporter signature motif; other site
243231007333	Walker B; other site
243231007334	D-loop; other site
243231007335	H-loop/switch region; other site
243231007336	lipid-A-disaccharide synthase; Reviewed; Region: lpxB; PRK00025
243231007337	ipid-A-disaccharide synthase; Provisional; Region: PRK14089
243231007338	DegT/DnrJ/EryC1/StrS aminotransferase family; Region: DegT_DnrJ_EryC1; pfam01041
243231007339	3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616
243231007340	inhibitor-cofactor binding pocket; inhibition site
243231007341	pyridoxal 5'-phosphate binding site [chemical binding]; other site
243231007342	catalytic residue [active]
243231007343	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
243231007344	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
243231007345	UDP-N-acetylglucosamine acyltransferase; Provisional; Region: PRK05289
243231007346	UDP-N-acetylglucosamine O-acyltransferase (UDP-GlcNAc acyltransferase): Proteins in this family catalyze the transfer of (R)-3-hydroxymyristic acid from its acyl carrier protein thioester to UDP-GlcNAc. It is the first enzyme in the lipid A biosynthetic...; Region: LbH_UDP-GlcNAc_AT; cd03351
243231007347	active site
243231007348	FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288
243231007349	UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Provisional; Region: lpxD; PRK00892
243231007350	UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase, LpxD; Region: LpxD; pfam04613
243231007351	UDP-3-O-acyl-glucosamine N-acyltransferase (LpxD): The enzyme catalyzes the transfer of 3-hydroxymyristic acid or 3-hydroxy-arachidic acid, depending on the organism, from the acyl carrier protein (ACP) to UDP-3-O-acyl-glucosamine to produce UDP-2; Region: LbH_LpxD; cd03352
243231007352	trimer interface [polypeptide binding]; other site
243231007353	active site
243231007354	UDP-GlcNAc binding site [chemical binding]; other site
243231007355	lipid binding site [chemical binding]; lipid-binding site
243231007356	Outer membrane protein (OmpH-like); Region: OmpH; pfam03938
243231007357	Surface antigen variable number repeat; Region: Surf_Ag_VNR; cl10520
243231007358	outer membrane protein assembly complex, YaeT protein; Region: OM_YaeT; TIGR03303
243231007359	Surface antigen variable number repeat; Region: Surf_Ag_VNR; cl10520
243231007360	Surface antigen variable number repeat; Region: Surf_Ag_VNR; cl10520
243231007361	Surface antigen variable number repeat; Region: Surf_Ag_VNR; cl10520
243231007362	Surface antigen variable number repeat; Region: Surf_Ag_VNR; cl10520
243231007363	Surface antigen; Region: Bac_surface_Ag; cl03097
243231007364	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
243231007365	This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE).  They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255
243231007366	Walker A/P-loop; other site
243231007367	ATP binding site [chemical binding]; other site
243231007368	Q-loop/lid; other site
243231007369	ABC transporter signature motif; other site
243231007370	Walker B; other site
243231007371	D-loop; other site
243231007372	H-loop/switch region; other site
243231007373	lipoprotein releasing system, transmembrane protein, LolC/E family; Region: lolCE; TIGR02212
243231007374	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
243231007375	FtsX-like permease family; Region: FtsX; cl15850
243231007376	lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484
243231007377	LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322
243231007378	dimer interface [polypeptide binding]; other site
243231007379	putative anticodon binding site; other site
243231007380	Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775
243231007381	motif 1; other site
243231007382	active site
243231007383	motif 2; other site
243231007384	motif 3; other site
243231007385	Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415
243231007386	Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415
243231007387	Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415
243231007388	Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415
243231007389	Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415
243231007390	Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415
243231007391	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; cl11587
243231007392	EVE domain; Region: EVE; cl00728
243231007393	Protein of unknown function (DUF1015); Region: DUF1015; cl01715
243231007394	Sporulation related domain; Region: SPOR; cl10051
243231007395	NlpC/P60 family; Region: NLPC_P60; cl11438
243231007396	peptide chain release factor 2; Validated; Region: prfB; PRK00578
243231007397	RF-1 domain; Region: RF-1; cl02875
243231007398	RF-1 domain; Region: RF-1; cl02875
243231007399	putative transposase OrfB; Reviewed; Region: PHA02517
243231007400	HTH-like domain; Region: HTH_21; pfam13276
243231007401	Integrase core domain; Region: rve; cl01316
243231007402	Integrase core domain; Region: rve_3; cl15866
243231007403	apolipoprotein N-acyltransferase; Reviewed; Region: lnt; PRK00302
243231007404	Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571
243231007405	putative active site [active]
243231007406	catalytic triad [active]
243231007407	putative dimer interface [polypeptide binding]; other site
243231007408	FOG: CBS domain [General function prediction only]; Region: COG0517
243231007409	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
243231007410	Transporter associated domain; Region: CorC_HlyC; cl08393
243231007411	Prokaryotic diacylglycerol kinase; Region: DAGK_prokar; cl00526
243231007412	PAP2_like proteins, diacylglycerol_kinase like sub-family. In some prokaryotes, PAP2_like phosphatase domains appear fused to E. coli DAGK-like trans-membrane diacylglycerol kinase domains. The cellular function of these architectures remains to be...; Region: PAP2_diacylglycerolkinase; cd03383
243231007413	active site
243231007414	Uncharacterized protein family UPF0054; Region: UPF0054; cl00402
243231007415	Predicted membrane-associated HD superfamily hydrolase [General function prediction only]; Region: COG1480
243231007416	7TM receptor with intracellular HD hydrolase; Region: 7TM-7TMR_HD; pfam07698
243231007417	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
243231007418	Zn2+ binding site [ion binding]; other site
243231007419	Mg2+ binding site [ion binding]; other site
243231007420	enolase; Provisional; Region: eno; PRK00077
243231007421	Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313
243231007422	dimer interface [polypeptide binding]; other site
243231007423	metal binding site [ion binding]; metal-binding site
243231007424	substrate binding pocket [chemical binding]; other site
243231007425	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
243231007426	Response regulator receiver domain; Region: Response_reg; pfam00072
243231007427	active site
243231007428	phosphorylation site [posttranslational modification]
243231007429	intermolecular recognition site; other site
243231007430	dimerization interface [polypeptide binding]; other site
243231007431	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
243231007432	dimerization interface [polypeptide binding]; other site
243231007433	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080
243231007434	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
243231007435	ATP binding site [chemical binding]; other site
243231007436	Mg2+ binding site [ion binding]; other site
243231007437	G-X-G motif; other site
243231007438	nicotinate phosphoribosyltransferase; Validated; Region: PRK09243
243231007439	Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570
243231007440	active site
243231007441	Isochorismatase family; Region: Isochorismatase; pfam00857
243231007442	Nicotinamidase/pyrazinamidase (PZase). Nicotinamidase, a ubiquitous enzyme in prokaryotes, converts nicotinamide to nicotinic acid (niacin) and ammonia, which in turn can be recycled to make nicotinamide adenine dinucleotide (NAD). The same enzyme is...; Region: nicotinamidase; cd01011
243231007443	catalytic triad [active]
243231007444	metal binding site [ion binding]; metal-binding site
243231007445	conserved cis-peptide bond; other site
243231007446	NeuB family; Region: NeuB; cl00496
243231007447	DAHP synthetase I family; Region: DAHP_synth_1; pfam00793
243231007448	Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686
243231007449	Alanine dehydrogenase/PNT, N-terminal domain; Region: AlaDh_PNT_N; cl15379
243231007450	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
243231007451	HDOD domain; Region: HDOD; pfam08668
243231007452	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
243231007453	Zn2+ binding site [ion binding]; other site
243231007454	Mg2+ binding site [ion binding]; other site
243231007455	Cache domain; Region: Cache_1; pfam02743
243231007456	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054
243231007457	PAS domain S-box; Region: sensory_box; TIGR00229
243231007458	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
243231007459	putative active site [active]
243231007460	heme pocket [chemical binding]; other site
243231007461	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
243231007462	dimer interface [polypeptide binding]; other site
243231007463	phosphorylation site [posttranslational modification]
243231007464	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
243231007465	ATP binding site [chemical binding]; other site
243231007466	Mg2+ binding site [ion binding]; other site
243231007467	G-X-G motif; other site
243231007468	Cytochrome c554 and c-prime; Region: Cytochrome_C554; pfam13435
243231007469	Cytochrome c554 and c-prime; Region: Cytochrome_C554; pfam13435
243231007470	Cytochrome c bacterial; Region: Cytochrome_cB; pfam11783
243231007471	Trehalose-6-phosphatase [Carbohydrate transport and metabolism]; Region: OtsB; COG1877
243231007472	Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391
243231007473	Na+/H+ antiporter 1; Region: Na_H_antiport_1; cl01133
243231007474	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
243231007475	ligand binding site [chemical binding]; other site
243231007476	AIR carboxylase; Region: AIRC; cl00310
243231007477	Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeB; cd00884
243231007478	active site clefts [active]
243231007479	zinc binding site [ion binding]; other site
243231007480	dimer interface [polypeptide binding]; other site
243231007481	ACT_MalLac-Enz CD includes the N-terminal ACT domain of putative NAD-dependent malic enzyme 1, Bacillus subtilis YqkI and related domains; Region: ACT_MalLac-Enz; cd04887
243231007482	Malic enzyme, N-terminal domain; Region: malic; pfam00390
243231007483	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
243231007484	NAD(P) binding pocket [chemical binding]; other site
243231007485	Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446
243231007486	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
243231007487	active site residue [active]
243231007488	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
243231007489	active site residue [active]
243231007490	putative inner membrane protein; Provisional; Region: PRK11099
243231007491	high affinity sulphate transporter 1; Region: sulP; TIGR00815
243231007492	Sulfate transporter family; Region: Sulfate_transp; cl15842
243231007493	Sulfate transporter family; Region: Sulfate_transp; cl15842
243231007494	Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042
243231007495	Response regulator receiver domain; Region: Response_reg; pfam00072
243231007496	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
243231007497	active site
243231007498	phosphorylation site [posttranslational modification]
243231007499	intermolecular recognition site; other site
243231007500	dimerization interface [polypeptide binding]; other site
243231007501	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
243231007502	metal binding site [ion binding]; metal-binding site
243231007503	active site
243231007504	I-site; other site
243231007505	Protein of unknown function (DUF3365); Region: DUF3365; pfam11845
243231007506	PAS domain S-box; Region: sensory_box; TIGR00229
243231007507	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
243231007508	putative active site [active]
243231007509	heme pocket [chemical binding]; other site
243231007510	Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852
243231007511	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
243231007512	putative active site [active]
243231007513	heme pocket [chemical binding]; other site
243231007514	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
243231007515	dimer interface [polypeptide binding]; other site
243231007516	phosphorylation site [posttranslational modification]
243231007517	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
243231007518	ATP binding site [chemical binding]; other site
243231007519	Mg2+ binding site [ion binding]; other site
243231007520	G-X-G motif; other site
243231007521	Response regulator receiver domain; Region: Response_reg; pfam00072
243231007522	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
243231007523	active site
243231007524	phosphorylation site [posttranslational modification]
243231007525	intermolecular recognition site; other site
243231007526	dimerization interface [polypeptide binding]; other site
243231007527	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cl00086
243231007528	Mechanosensitive ion channel; Region: MS_channel; pfam00924
243231007529	Permease SLC13 (solute carrier 13).  The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115
243231007530	transmembrane helices; other site
243231007531	Anion permease ArsB/NhaD.  These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life.  A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl15357
243231007532	Anion permease ArsB/NhaD.  These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life.  A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl15357
243231007533	Anion permease ArsB/NhaD.  These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life.  A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl15357
243231007534	Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane]; Region: Cfa; COG2230
243231007535	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
243231007536	S-adenosylmethionine binding site [chemical binding]; other site
243231007537	Protein of unknown function (DUF1499); Region: DUF1499; cl01841
243231007538	Protein of unknown function (DUF1475); Region: DUF1475; pfam07343
243231007539	START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643
243231007540	hydrophobic ligand binding site; other site
243231007541	Phospholipid methyltransferase; Region: PEMT; cl00763
243231007542	Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381
243231007543	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474
243231007544	Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; cl02930
243231007545	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
243231007546	Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246
243231007547	Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391
243231007548	Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689
243231007549	Lipocalin / cytosolic fatty-acid binding protein family; Region: Lipocalin; cl01150
243231007550	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
243231007551	Predicted NAD/FAD-binding protein [General function prediction only]; Region: COG2907
243231007552	Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane]; Region: Cfa; COG2230
243231007553	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
243231007554	S-adenosylmethionine binding site [chemical binding]; other site
243231007555	Protein of unknown function (DUF2878); Region: DUF2878; pfam11086
243231007556	Predicted membrane protein (DUF2177); Region: DUF2177; cl02014
243231007557	Cytidylate kinase-like family; Region: Cytidylate_kin2; pfam13189
243231007558	Uncharacterized conserved protein [Function unknown]; Region: COG1615; cl09133
243231007559	Uncharacterized protein family (UPF0182); Region: UPF0182; pfam03699
243231007560	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
243231007561	Ligand Binding Site [chemical binding]; other site
243231007562	Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391
243231007563	HAD-superfamily hydrolase, subfamily IIB; Region: HAD-SF-IIB; TIGR01484
243231007564	Trehalose-6-phosphate synthase [Carbohydrate transport and metabolism]; Region: OtsA; COG0380
243231007565	Trehalose-6-Phosphate Synthase (TPS) is a glycosyltransferase that catalyses the synthesis of alpha,alpha-1,1-trehalose-6-phosphate from glucose-6-phosphate using a UDP-glucose donor. It is a key enzyme in the trehalose synthesis pathway. Trehalose is a...; Region: GT1_TPS; cd03788
243231007566	active site
243231007567	homotetramer interface [polypeptide binding]; other site
243231007568	Na+/H+ antiporter subunit; Region: PhaG_MnhG_YufB; cl00583
243231007569	Multiple resistance and pH regulation protein F (MrpF / PhaF); Region: MrpF_PhaF; cl09154
243231007570	Na+/H+ ion antiporter subunit; Region: MNHE; cl00807
243231007571	putative monovalent cation/H+ antiporter subunit D; Reviewed; Region: PRK12663
243231007572	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; cl14187
243231007573	NADH-ubiquinone/plastoquinone oxidoreductase chain 4L; Region: Oxidored_q2; cl00492
243231007574	putative monovalent cation/H+ antiporter subunit A; Reviewed; Region: PRK12647
243231007575	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; cl14187
243231007576	Domain of unknown function (DUF4040); Region: DUF4040; cl00676
243231007577	Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cl00120
243231007578	Domain of unknown function (DUF389); Region: DUF389; cl00781
243231007579	Protein of unknown function, DUF481; Region: DUF481; cl01213
243231007580	Protein of unknown function (DUF1049); Region: DUF1049; cl01539
243231007581	K+ potassium transporter; Region: K_trans; cl15781
243231007582	Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; cl02930
243231007583	plasma-membrane proton-efflux P-type ATPase; Region: ATPase-IIIA_H; TIGR01647
243231007584	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
243231007585	Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246
243231007586	Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391
243231007587	Predicted symporter [General function prediction only]; Region: DhlC; COG4147
243231007588	Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u4; cd11480
243231007589	Na binding site [ion binding]; other site
243231007590	Protein of unknown function, DUF485; Region: DUF485; cl01231
243231007591	Transcriptional regulator [Transcription]; Region: IclR; COG1414
243231007592	Helix-turn-helix domains; Region: HTH; cl00088
243231007593	Bacterial transcriptional regulator; Region: IclR; pfam01614
243231007594	Mechanosensitive ion channel; Region: MS_channel; pfam00924
243231007595	N-terminal Early set domain associated with the catalytic domain of Maltooligosyl trehalose trehalohydrolase (also called Glycosyltrehalose trehalohydrolase) and similar proteins; Region: E_set_MTHase_like_N; cd02853
243231007596	malto-oligosyltrehalose trehalohydrolase; Region: trehalose_TreZ; TIGR02402
243231007597	Alpha amylase catalytic domain found in Glycosyltrehalose trehalohydrolase (also called Maltooligosyl trehalose Trehalohydrolase); Region: AmyAc_GTHase; cd11325
243231007598	catalytic site [active]
243231007599	active site
243231007600	Domain of unknown function (DUF3459); Region: DUF3459; pfam11941
243231007601	N-terminal putative catalytic domain of mainly uncharacterized prokaryotic proteins similar to archaeal thermoactive amylopullulanases; glycoside hydrolase family 57 (GH57); Region: GH57N_APU_like_1; cd10797
243231007602	Glycosyl hydrolase family 57; Region: Glyco_hydro_57; pfam03065
243231007603	active site
243231007604	catalytic site [active]
243231007605	Domain of unknown function (DUF3536); Region: DUF3536; pfam12055
243231007606	maltooligosyl trehalose synthase; Provisional; Region: PRK14511
243231007607	Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893
243231007608	Alpha amylase catalytic domain found in maltooligosyl trehalose synthase (MTSase); Region: AmyAc_MTSase; cd11336
243231007609	active site
243231007610	catalytic site [active]
243231007611	trehalose synthase; Region: treS_nterm; TIGR02456
243231007612	Alpha amylase catalytic domain found in Trehalose synthetase; Region: AmyAc_TreS; cd11334
243231007613	active site
243231007614	catalytic site [active]
243231007615	Uncharacterized protein, probably involved in trehalose biosynthesis [Carbohydrate transport and metabolism]; Region: Ble; cl01286
243231007616	Transcriptional regulators [Transcription]; Region: MarR; COG1846
243231007617	Helix-turn-helix domains; Region: HTH; cl00088
243231007618	Helix-turn-helix domains; Region: HTH; cl00088
243231007619	CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cd00400
243231007620	Voltage gated chloride channel; Region: Voltage_CLC; pfam00654
243231007621	Cl- selectivity filter; other site
243231007622	Cl- binding residues [ion binding]; other site
243231007623	pore gating glutamate residue; other site
243231007624	dimer interface [polypeptide binding]; other site
243231007625	FOG: CBS domain [General function prediction only]; Region: COG0517
243231007626	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with either the SpoIVFB domain (sporulation protein, stage IV cell wall formation, F locus, promoter-distal B) or the chloride channel protein EriC; Region: CBS_pair_SpoIVFB_EriC_assoc2; cd04613
243231007627	Cupin domain; Region: Cupin_2; cl09118
243231007628	dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254
243231007629	RmlD substrate binding domain; Region: RmlD_sub_bind; pfam04321
243231007630	NADP binding site [chemical binding]; other site
243231007631	active site
243231007632	putative substrate binding site [chemical binding]; other site
243231007633	dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088
243231007634	dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246
243231007635	NAD binding site [chemical binding]; other site
243231007636	substrate binding site [chemical binding]; other site
243231007637	homodimer interface [polypeptide binding]; other site
243231007638	active site
243231007639	LPS assembly outer membrane complex protein LptD; Provisional; Region: PRK03761
243231007640	Organic solvent tolerance protein; Region: OstA_C; pfam04453
243231007641	Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285
243231007642	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
243231007643	acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654
243231007644	Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl15772
243231007645	tryptophan synthase subunit alpha; Provisional; Region: trpA; PRK13111
243231007646	Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724
243231007647	substrate binding site [chemical binding]; other site
243231007648	active site
243231007649	catalytic residues [active]
243231007650	heterodimer interface [polypeptide binding]; other site
243231007651	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
243231007652	dimerization interface [polypeptide binding]; other site
243231007653	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
243231007654	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
243231007655	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
243231007656	dimer interface [polypeptide binding]; other site
243231007657	putative CheW interface [polypeptide binding]; other site
243231007658	Methyl-accepting chemotaxis protein (MCP) signalling domain; Region: MCPsignal; pfam00015
243231007659	Late embryogenesis abundant protein; Region: LEA_2; cl12118
243231007660	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic 'goose-type' lysozymes (GEWL).  LTs catalyze...; Region: LT_GEWL; cd00254
243231007661	N-acetyl-D-glucosamine binding site [chemical binding]; other site
243231007662	catalytic residue [active]
243231007663	Tryptophan synthase-beta:  Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446
243231007664	Pyridoxal-phosphate dependent enzyme; Region: PALP; pfam00291
243231007665	pyridoxal 5'-phosphate binding site [chemical binding]; other site
243231007666	catalytic residue [active]
243231007667	Macro domain, Poa1p_like family. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ADP-ribose...; Region: Macro_Poa1p_like; cd02901
243231007668	ADP-ribose binding site [chemical binding]; other site
243231007669	Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are monomeric; Region: PRAI; cd00405
243231007670	active site
243231007671	Tryptophan synthase-beta:  Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446
243231007672	Pyridoxal-phosphate dependent enzyme; Region: PALP; pfam00291
243231007673	pyridoxal 5'-phosphate binding site [chemical binding]; other site
243231007674	catalytic residue [active]
243231007675	Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331
243231007676	active site
243231007677	ribulose/triose binding site [chemical binding]; other site
243231007678	phosphate binding site [ion binding]; other site
243231007679	substrate (anthranilate) binding pocket [chemical binding]; other site
243231007680	product (indole) binding pocket [chemical binding]; other site
243231007681	anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188
243231007682	Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885
243231007683	Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591
243231007684	para-aminobenzoate synthase component II; Provisional; Region: PRK08857
243231007685	Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743
243231007686	glutamine binding [chemical binding]; other site
243231007687	catalytic triad [active]
243231007688	anthranilate synthase component I; Provisional; Region: PRK13565
243231007689	Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715
243231007690	chorismate binding enzyme; Region: Chorismate_bind; cl10555
243231007691	GAF domain; Region: GAF; cl15785
243231007692	GAF domain; Region: GAF_2; pfam13185
243231007693	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
243231007694	dimer interface [polypeptide binding]; other site
243231007695	phosphorylation site [posttranslational modification]
243231007696	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
243231007697	ATP binding site [chemical binding]; other site
243231007698	G-X-G motif; other site
243231007699	Protein of unknown function (DUF1638); Region: DUF1638; pfam07796
243231007700	methyltransferase, MtaA/CmuA family; Region: mtaA_cmuA; TIGR01463
243231007701	The URO-D _like protein superfamily includes bacterial and eukaryotic uroporphyrinogen decarboxylases (URO-D), coenzyme M methyltransferases and other putative bacterial methyltransferases. Uroporphyrinogen decarboxylase (URO-D) decarboxylates the four...; Region: URO-D_like; cd03465
243231007702	Predicted cobalamin binding protein [General function prediction only]; Region: COG5012
243231007703	B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293
243231007704	B12 binding site [chemical binding]; other site
243231007705	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054
243231007706	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
243231007707	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
243231007708	putative active site [active]
243231007709	heme pocket [chemical binding]; other site
243231007710	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
243231007711	dimer interface [polypeptide binding]; other site
243231007712	phosphorylation site [posttranslational modification]
243231007713	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
243231007714	ATP binding site [chemical binding]; other site
243231007715	Mg2+ binding site [ion binding]; other site
243231007716	G-X-G motif; other site
243231007717	Periplasmic binding protein; Region: Peripla_BP_6; pfam13458
243231007718	Periplasmic binding domain of ATP-binding cassette transporter-like systems that belong to the type I periplasmic binding fold protein superfamily; Region: PBP1_ABC_transporter_LIVBP_like; cd06268
243231007719	ligand binding site [chemical binding]; other site
243231007720	heat shock protein 90; Provisional; Region: PRK05218
243231007721	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075
243231007722	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; cl12078
243231007723	putative transposase OrfB; Reviewed; Region: PHA02517
243231007724	HTH-like domain; Region: HTH_21; pfam13276
243231007725	Integrase core domain; Region: rve; cl01316
243231007726	Integrase core domain; Region: rve_3; cl15866
243231007727	Transposase; Region: DEDD_Tnp_IS110; pfam01548
243231007728	Sel1 repeat; Region: Sel1; cl02723
243231007729	Sel1 repeat; Region: Sel1; cl02723
243231007730	Sel1 repeat; Region: Sel1; cl02723
243231007731	Transposase IS200 like; Region: Y1_Tnp; cl00848
243231007732	Transposase IS200 like; Region: Y1_Tnp; cl00848
243231007733	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761
243231007734	HipA N-terminal domain; Region: Couple_hipA; cl11853
243231007735	HipA-like N-terminal domain; Region: HipA_N; pfam07805
243231007736	HipA-like C-terminal domain; Region: HipA_C; pfam07804
243231007737	Acetoacetate decarboxylase (ADC); Region: ADC; cl01919
243231007738	Sensory domain found in PocR; Region: PocR; pfam10114
243231007739	Predicted sensor domain [Signal transduction mechanisms / Transcription]; Region: PocR; COG4936
243231007740	PAS domain S-box; Region: sensory_box; TIGR00229
243231007741	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
243231007742	putative active site [active]
243231007743	heme pocket [chemical binding]; other site
243231007744	GAF domain; Region: GAF_2; pfam13185
243231007745	GAF domain; Region: GAF; cl15785
243231007746	Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852
243231007747	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
243231007748	putative active site [active]
243231007749	heme pocket [chemical binding]; other site
243231007750	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
243231007751	dimer interface [polypeptide binding]; other site
243231007752	phosphorylation site [posttranslational modification]
243231007753	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
243231007754	ATP binding site [chemical binding]; other site
243231007755	Mg2+ binding site [ion binding]; other site
243231007756	G-X-G motif; other site
243231007757	Response regulator receiver domain; Region: Response_reg; pfam00072
243231007758	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
243231007759	active site
243231007760	phosphorylation site [posttranslational modification]
243231007761	intermolecular recognition site; other site
243231007762	dimerization interface [polypeptide binding]; other site
243231007763	Domain of unknown function (DUF4124); Region: DUF4124; pfam13511
243231007764	UV radiation resistance protein and autophagy-related subunit 14; Region: Atg14; pfam10186
243231007765	Protein of unknown function (DUF3620); Region: DUF3620; cl02233
243231007766	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
243231007767	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
243231007768	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
243231007769	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
243231007770	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
243231007771	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
243231007772	DnaJ-class molecular chaperone with C-terminal Zn finger domain [Posttranslational modification, protein turnover, chaperones]; Region: DnaJ; COG0484
243231007773	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
243231007774	HSP70 interaction site [polypeptide binding]; other site
243231007775	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747
243231007776	substrate binding site [polypeptide binding]; other site
243231007777	dimer interface [polypeptide binding]; other site
243231007778	Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain  (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464
243231007779	putative dimer interface [polypeptide binding]; other site
243231007780	Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain  (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464
243231007781	putative dimer interface [polypeptide binding]; other site
243231007782	Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain  (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464
243231007783	putative dimer interface [polypeptide binding]; other site
243231007784	Escherichia coli YaeB and related proteins; Region: UPF0066; cd09281
243231007785	homodimer interaction site [polypeptide binding]; other site
243231007786	cofactor binding site; other site
243231007787	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
243231007788	This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE).  They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255
243231007789	Walker A/P-loop; other site
243231007790	ATP binding site [chemical binding]; other site
243231007791	Q-loop/lid; other site
243231007792	ABC transporter signature motif; other site
243231007793	Walker B; other site
243231007794	D-loop; other site
243231007795	H-loop/switch region; other site
243231007796	Predicted ABC-type transport system involved in lysophospholipase L1 biosynthesis, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3127
243231007797	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
243231007798	FtsX-like permease family; Region: FtsX; cl15850
243231007799	FtsX-like permease family; Region: FtsX; cl15850
243231007800	Lysophospholipase L1-like subgroup of SGNH-hydrolases. The best characterized member in this family is TesA, an E. coli periplasmic protein with thioesterase, esterase, arylesterase, protease and lysophospholipase activity; Region: Lysophospholipase_L1_like; cd01822
243231007801	active site
243231007802	catalytic triad [active]
243231007803	oxyanion hole [active]
243231007804	switch loop; other site
243231007805	CheW, a small regulator protein, unique to the chemotaxis signalling in prokaryotes and archea. CheW interacts with the histidine kinase CheA, most likely with the related regulatory domain of CheA. CheW is proposed to form signalling arrays together...; Region: CheW; cd00732
243231007806	putative CheA interaction surface; other site
243231007807	Coenzyme F420-reducing hydrogenase, gamma subunit [Energy production and conversion]; Region: FrhG; COG1941
243231007808	NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; cl15792
243231007809	Nickel-dependent hydrogenase; Region: NiFeSe_Hases; cl00417
243231007810	RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409
243231007811	4Fe-4S dicluster domain; Region: Fer4_7; pfam12838
243231007812	coenzyme F420-reducing hydrogenase delta subunit (putative coenzyme F420 hydrogenase processing subunit); Region: frhD; TIGR00130
243231007813	Hydrogenase specific C-terminal endopeptidases, also called Hydrogen Maturation Proteases (H2MP). These enzymes belong to the peptidase family M52. Maturation of [FeNi] hydrogenases includes formation of the nickel metallocenter, proteolytic processing...; Region: H2MP; cd00518
243231007814	nickel binding site [ion binding]; other site
243231007815	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
243231007816	dimer interface [polypeptide binding]; other site
243231007817	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
243231007818	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
243231007819	dimer interface [polypeptide binding]; other site
243231007820	putative CheW interface [polypeptide binding]; other site
243231007821	putative CheW interface [polypeptide binding]; other site
243231007822	OAH/OAS sulfhydrylase; Region: OAH_OAS_sulfhy; TIGR01326
243231007823	CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614
243231007824	homodimer interface [polypeptide binding]; other site
243231007825	substrate-cofactor binding pocket; other site
243231007826	pyridoxal 5'-phosphate binding site [chemical binding]; other site
243231007827	catalytic residue [active]
243231007828	This family is the oxydase domain of NRPS (non-ribosomal peptide synthetase) and other proteins that modify polypeptides by cyclizing a thioester to form a ring. These include epoB, part of the epothilone biosynthesis pathway; tubD, part of the tubulysin...; Region: mcbC-like_oxidoreductase; cd02142
243231007829	putative FMN binding site [chemical binding]; other site
243231007830	NADPH bind site [chemical binding]; other site
243231007831	pyruvate carboxylase; Reviewed; Region: PRK12999
243231007832	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
243231007833	ATP-grasp domain; Region: ATP-grasp_4; cl03087
243231007834	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; cl08365
243231007835	Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937
243231007836	active site
243231007837	catalytic residues [active]
243231007838	metal binding site [ion binding]; metal-binding site
243231007839	homodimer binding site [polypeptide binding]; other site
243231007840	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
243231007841	carboxyltransferase (CT) interaction site; other site
243231007842	biotinylation site [posttranslational modification]; other site
243231007843	Parvulin-like peptidyl-prolyl isomerase [Posttranslational modification, protein turnover, chaperones]; Region: SurA; COG0760
243231007844	SurA N-terminal domain; Region: SurA_N_3; cl07813
243231007845	PPIC-type PPIASE domain; Region: Rotamase; cl08278
243231007846	Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403
243231007847	Membrane-bound serine protease (ClpP class) [Posttranslational modification, protein turnover, chaperones]; Region: NfeD; COG1030
243231007848	Nodulation formation efficiency D (NfeD) is a membrane-bound ClpP-class protease; Region: Clp_protease_NfeD_1; cd07020
243231007849	dimer interface [polypeptide binding]; other site
243231007850	active site residues [active]
243231007851	NfeD-like C-terminal, partner-binding; Region: NfeD; cl00686
243231007852	Cytochrome c; Region: Cytochrom_C; cl11414
243231007853	AAA domain; Region: AAA_32; pfam13654
243231007854	Subunit ChlI of Mg-chelatase; Region: ChlI; cl12214
243231007855	Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057
243231007856	branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856
243231007857	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
243231007858	E3 interaction surface; other site
243231007859	lipoyl attachment site [posttranslational modification]; other site
243231007860	e3 binding domain; Region: E3_binding; pfam02817
243231007861	2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; cl02008
243231007862	Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022
243231007863	Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036
243231007864	alpha subunit interface [polypeptide binding]; other site
243231007865	TPP binding site [chemical binding]; other site
243231007866	heterodimer interface [polypeptide binding]; other site
243231007867	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
243231007868	Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588
243231007869	dimer interface [polypeptide binding]; other site
243231007870	Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; cl09153
243231007871	Plasmid stabilisation system protein; Region: Plasmid_stabil; cl11422
243231007872	DsrE/DsrF-like family; Region: DrsE; cl00672
243231007873	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
243231007874	S-adenosylmethionine binding site [chemical binding]; other site
243231007875	Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399
243231007876	synthetase active site [active]
243231007877	NTP binding site [chemical binding]; other site
243231007878	metal binding site [ion binding]; metal-binding site
243231007879	pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_y; TIGR03182
243231007880	Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000
243231007881	tetramer interface [polypeptide binding]; other site
243231007882	TPP-binding site [chemical binding]; other site
243231007883	heterodimer interface [polypeptide binding]; other site
243231007884	phosphorylation loop region [posttranslational modification]
243231007885	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
243231007886	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
243231007887	substrate binding pocket [chemical binding]; other site
243231007888	membrane-bound complex binding site; other site
243231007889	hinge residues; other site
243231007890	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
243231007891	dimer interface [polypeptide binding]; other site
243231007892	phosphorylation site [posttranslational modification]
243231007893	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
243231007894	ATP binding site [chemical binding]; other site
243231007895	Mg2+ binding site [ion binding]; other site
243231007896	G-X-G motif; other site
243231007897	aconitate hydratase; Validated; Region: PRK07229
243231007898	Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: AcnA_Bact; cd01585
243231007899	substrate binding site [chemical binding]; other site
243231007900	ligand binding site [chemical binding]; other site
243231007901	Bacterial Aconitase-like swivel domain. Aconitase (aconitate hydratase or citrate hydrolyase) catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle.  Cis-aconitate is formed as an intermediate product during the course...; Region: AcnA_Bact_Swivel; cd01579
243231007902	substrate binding site [chemical binding]; other site
243231007903	dihydrolipoamide dehydrogenase; Validated; Region: PRK06327
243231007904	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
243231007905	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
243231007906	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
243231007907	FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790
243231007908	Sel1 repeat; Region: Sel1; cl02723
243231007909	Sel1 repeat; Region: Sel1; cl02723
243231007910	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
243231007911	dihydrolipoamide succinyltransferase; Validated; Region: PRK05704
243231007912	E3 interaction surface; other site
243231007913	lipoyl attachment site [posttranslational modification]; other site
243231007914	2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; cl02008
243231007915	2-oxoglutarate dehydrogenase E1 component; Reviewed; Region: sucA; PRK09404
243231007916	Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016
243231007917	TPP-binding site [chemical binding]; other site
243231007918	Pyrimidine (PYR) binding domain of thiamine pyrophosphate (TPP)-dependent enzymes; Region: TPP_enzyme_PYR; cl11410
243231007919	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
243231007920	Conserved domain frequently associated with peptide methionine sulfoxide reductase [Posttranslational modification, protein turnover, chaperones]; Region: COG0229
243231007921	methionine sulfoxide reductase B; Provisional; Region: PRK00222; cl15841
243231007922	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
243231007923	metal-binding site [ion binding]
243231007924	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217
243231007925	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
243231007926	metal-binding site [ion binding]
243231007927	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
243231007928	Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391
243231007929	Domain of unknown function DUF20; Region: UPF0118; pfam01594
243231007930	pheromone autoinducer 2 transporter; Reviewed; Region: tqsA; cl00465
243231007931	pheromone autoinducer 2 transporter; Reviewed; Region: tqsA; cl00465
243231007932	Uncharacterized protein family (UPF0158); Region: UPF0158; pfam03682
243231007933	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
243231007934	Escherichia coli YbbF/LpxH and related proteins, metallophosphatase domain; Region: MPP_YbbF-LpxH; cd07398
243231007935	putative active site [active]
243231007936	putative metal binding site [ion binding]; other site
243231007937	Flagellin N-methylase; Region: FliB; cl00497
243231007938	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009
243231007939	Virulence factor BrkB; Region: Virul_fac_BrkB; cl07918
243231007940	YtxH-like protein; Region: YtxH; cl02079
243231007941	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
243231007942	Homoserine acetyltransferase [Amino acid transport and metabolism]; Region: MET2; COG2021
243231007943	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
243231007944	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
243231007945	Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446
243231007946	integron integrase; Region: integrase_gron; TIGR02249
243231007947	IntI (E2) integrases, site-specific tyrosine recombinases, DNA breaking-rejoining enzymes, N- and C-terminal domains. This CD includes integrases which are components of multiresistant integrons and mediate recombination between a proximal attI site and...; Region: INT_IntI; cd01193
243231007948	Int/Topo IB signature motif; other site
243231007949	RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651
243231007950	Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078
243231007951	putative active site [active]
243231007952	putative NTP binding site [chemical binding]; other site
243231007953	putative nucleic acid binding site [nucleotide binding]; other site
243231007954	Group II intron, maturase-specific domain; Region: GIIM; pfam08388
243231007955	PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881
243231007956	oligomeric interface; other site
243231007957	putative active site [active]
243231007958	homodimer interface [polypeptide binding]; other site
243231007959	Antidote-toxin recognition MazE; Region: Antitoxin-MazE; cl00877
243231007960	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
243231007961	GAF domain; Region: GAF; cl15785
243231007962	Sigma54-dependent transcription regulator containing an AAA-type ATPase domain and a DNA-binding domain [Transcription / Signal transduction mechanisms]; Region: RtcR; COG4650
243231007963	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
243231007964	Walker A motif; other site
243231007965	ATP binding site [chemical binding]; other site
243231007966	Walker B motif; other site
243231007967	arginine finger; other site
243231007968	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
243231007969	binding surface
243231007970	TPR motif; other site
243231007971	TPR repeat; Region: TPR_11; pfam13414
243231007972	TPR repeat; Region: TPR_11; pfam13414
243231007973	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
243231007974	binding surface
243231007975	TPR motif; other site
243231007976	TPR repeat; Region: TPR_11; pfam13414
243231007977	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
243231007978	binding surface
243231007979	TPR motif; other site
243231007980	TPR repeat; Region: TPR_11; pfam13414
243231007981	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
243231007982	S-adenosylmethionine binding site [chemical binding]; other site
243231007983	Tetratricopeptide repeat; Region: TPR_16; pfam13432
243231007984	TPR repeat; Region: TPR_11; pfam13414
243231007985	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
243231007986	binding surface
243231007987	TPR motif; other site
243231007988	TPR repeat; Region: TPR_11; pfam13414
243231007989	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
243231007990	binding surface
243231007991	TPR motif; other site
243231007992	B12 binding domain_like associated with radical SAM domain. This domain shows similarity with B12 (adenosylcobamide) binding domains found in several enzymes, such as glutamate mutase, methionine synthase and methylmalonyl-CoA mutase, but it lacks the...; Region: radical_SAM_B12_BD; cd02068
243231007993	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
243231007994	Radical SAM superfamily; Region: Radical_SAM; pfam04055
243231007995	FeS/SAM binding site; other site
243231007996	Tetratricopeptide repeat; Region: TPR_16; pfam13432
243231007997	Potassium-transporting ATPase A subunit; Region: KdpA; cl00903
243231007998	potassium-transporting ATPase subunit B; Provisional; Region: PRK01122
243231007999	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
243231008000	K+-transporting ATPase, c chain; Region: KdpC; cl00944
243231008001	Osmosensitive K+ channel histidine kinase [Signal transduction mechanisms]; Region: KdpD; COG2205
243231008002	Osmosensitive K+ channel His kinase sensor domain; Region: KdpD; pfam02702
243231008003	USP domain is located between the N-terminal sensor domain and C-terminal catalytic domain of this Osmosensitive K+ channel histidine kinase family. The family of KdpD sensor kinase proteins regulates the kdpFABC operon responsible for potassium...; Region: USP_OKCHK; cd01987
243231008004	Ligand Binding Site [chemical binding]; other site
243231008005	Domain of unknown function (DUF4118); Region: DUF4118; pfam13493
243231008006	GAF domain; Region: GAF; cl15785
243231008007	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
243231008008	dimer interface [polypeptide binding]; other site
243231008009	phosphorylation site [posttranslational modification]
243231008010	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
243231008011	ATP binding site [chemical binding]; other site
243231008012	Mg2+ binding site [ion binding]; other site
243231008013	G-X-G motif; other site
243231008014	DNA-binding transcriptional activator KdpE; Provisional; Region: PRK10529
243231008015	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
243231008016	active site
243231008017	phosphorylation site [posttranslational modification]
243231008018	intermolecular recognition site; other site
243231008019	dimerization interface [polypeptide binding]; other site
243231008020	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
243231008021	DNA binding site [nucleotide binding]
243231008022	K+ potassium transporter; Region: K_trans; cl15781
243231008023	Predicted GTPase [General function prediction only]; Region: COG2403
243231008024	AAK_CK: Carbamate kinase (CK) catalyzes both the ATP-phosphorylation of carbamate and carbamoyl phosphate (CP) utilization with the production of ATP from ADP and CP. Both CK (this CD) and nonhomologous CP synthetase synthesize carbamoyl phosphate, an...; Region: AAK_CK; cd04235
243231008025	carbamate kinase-like carbamoyl phosphate synthetase; Reviewed; Region: PRK12454
243231008026	putative substrate binding site [chemical binding]; other site
243231008027	nucleotide binding site [chemical binding]; other site
243231008028	nucleotide binding site [chemical binding]; other site
243231008029	homodimer interface [polypeptide binding]; other site
243231008030	Uncharacterized conserved protein [Function unknown]; Region: COG1915
243231008031	TatD like proteins;  E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310
243231008032	active site
243231008033	radical SAM protein, TatD family-associated; Region: tatD_link_rSAM; TIGR04038
243231008034	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
243231008035	FeS/SAM binding site; other site
243231008036	oxalate/formate antiporter family transporter; Region: 2A0111; TIGR00890
243231008037	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
243231008038	putative substrate translocation pore; other site
243231008039	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
243231008040	Major Facilitator Superfamily; Region: MFS_1; pfam07690
243231008041	putative substrate translocation pore; other site
243231008042	Cache domain; Region: Cache_1; pfam02743
243231008043	sensory histidine kinase AtoS; Provisional; Region: PRK11360
243231008044	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
243231008045	dimerization interface [polypeptide binding]; other site
243231008046	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
243231008047	dimer interface [polypeptide binding]; other site
243231008048	phosphorylation site [posttranslational modification]
243231008049	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
243231008050	ATP binding site [chemical binding]; other site
243231008051	Mg2+ binding site [ion binding]; other site
243231008052	G-X-G motif; other site
243231008053	NHL repeat; Region: NHL; pfam01436
243231008054	cytochrome c nitrite reductase, pentaheme subunit; Region: cyt_nit_nrfB; TIGR03146
243231008055	Doubled CXXCH motif (Paired_CXXCH_1); Region: Paired_CXXCH_1; cl09905
243231008056	Doubled CXXCH motif (Paired_CXXCH_1); Region: Paired_CXXCH_1; cl09905
243231008057	Doubled CXXCH motif (Paired_CXXCH_1); Region: Paired_CXXCH_1; cl09905
243231008058	Doubled CXXCH motif (Paired_CXXCH_1); Region: Paired_CXXCH_1; cl09905
243231008059	Doubled CXXCH motif (Paired_CXXCH_1); Region: Paired_CXXCH_1; cl09905
243231008060	Doubled CXXCH motif (Paired_CXXCH_1); Region: Paired_CXXCH_1; cl09905
243231008061	Doubled CXXCH motif (Paired_CXXCH_1); Region: Paired_CXXCH_1; cl09905
243231008062	Doubled CXXCH motif (Paired_CXXCH_1); Region: Paired_CXXCH_1; cl09905
243231008063	decaheme c-type cytochrome, DmsE family; Region: decahem_SO; TIGR03508
243231008064	Doubled CXXCH motif (Paired_CXXCH_1); Region: Paired_CXXCH_1; cl09905
243231008065	Doubled CXXCH motif (Paired_CXXCH_1); Region: Paired_CXXCH_1; cl09905
243231008066	Doubled CXXCH motif (Paired_CXXCH_1); Region: Paired_CXXCH_1; cl09905
243231008067	Doubled CXXCH motif (Paired_CXXCH_1); Region: Paired_CXXCH_1; cl09905
243231008068	decaheme c-type cytochrome, DmsE family; Region: decahem_SO; TIGR03508
243231008069	Doubled CXXCH motif (Paired_CXXCH_1); Region: Paired_CXXCH_1; cl09905
243231008070	Doubled CXXCH motif (Paired_CXXCH_1); Region: Paired_CXXCH_1; cl09905
243231008071	Doubled CXXCH motif (Paired_CXXCH_1); Region: Paired_CXXCH_1; cl09905
243231008072	Doubled CXXCH motif (Paired_CXXCH_1); Region: Paired_CXXCH_1; cl09905
243231008073	SurA N-terminal domain; Region: SurA_N_3; cl07813
243231008074	PPIC-type PPIASE domain; Region: Rotamase; cl08278
243231008075	PPIC-type PPIASE domain; Region: Rotamase; cl08278
243231008076	Putative bacterial lipoprotein (DUF799); Region: DUF799; cl01813
243231008077	Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes; Region: FA58C; cl12042
243231008078	spermidine synthase; Provisional; Region: PRK03612
243231008079	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911
243231008080	SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450
243231008081	Response regulator receiver domain; Region: Response_reg; pfam00072
243231008082	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
243231008083	active site
243231008084	phosphorylation site [posttranslational modification]
243231008085	intermolecular recognition site; other site
243231008086	dimerization interface [polypeptide binding]; other site
243231008087	sensory histidine kinase AtoS; Provisional; Region: PRK11360
243231008088	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain [Transcription / Signal transduction mechanisms]; Region: PspF; COG1221
243231008089	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
243231008090	Walker A motif; other site
243231008091	ATP binding site [chemical binding]; other site
243231008092	Walker B motif; other site
243231008093	arginine finger; other site
243231008094	Helix-turn-helix domains; Region: HTH; cl00088
243231008095	Cache domain; Region: Cache_1; pfam02743
243231008096	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
243231008097	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054
243231008098	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
243231008099	dimer interface [polypeptide binding]; other site
243231008100	phosphorylation site [posttranslational modification]
243231008101	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
243231008102	ATP binding site [chemical binding]; other site
243231008103	Mg2+ binding site [ion binding]; other site
243231008104	G-X-G motif; other site
243231008105	Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl15769
243231008106	Tetratricopeptide repeat; Region: TPR_16; pfam13432
243231008107	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
243231008108	binding surface
243231008109	Tetratricopeptide repeat; Region: TPR_16; pfam13432
243231008110	TPR motif; other site
243231008111	DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179
243231008112	Ligand binding site; other site
243231008113	Putative Catalytic site; other site
243231008114	DXD motif; other site
243231008115	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
243231008116	S-adenosylmethionine binding site [chemical binding]; other site
243231008117	CHASE4 domain; Region: CHASE4; cl01308
243231008118	PAS domain S-box; Region: sensory_box; TIGR00229
243231008119	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459
243231008120	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
243231008121	metal binding site [ion binding]; metal-binding site
243231008122	active site
243231008123	I-site; other site
243231008124	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
243231008125	Cytochrome c; Region: Cytochrom_C; cl11414
243231008126	Cytochrome c; Region: Cytochrom_C; cl11414
243231008127	Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897
243231008128	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
243231008129	active site residue [active]
243231008130	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
243231008131	active site residue [active]
243231008132	Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247
243231008133	Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448
243231008134	active site residue [active]
243231008135	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125
243231008136	active site residue [active]
243231008137	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
243231008138	active site residue [active]
243231008139	benzoyl-CoA reductase, bzd-type, N subunit; Region: benz_CoA_bzdN; cl11464
243231008140	2-hydroxyglutaryl-CoA dehydratase, D-component; Region: HGD-D; pfam06050
243231008141	FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121
243231008142	SirA_like_N, a protein of unknown function with an N-terminal SirA-like domain.  The SirA, YedF, YeeD protein family is present in bacteria as well as archaea. SirA (also known as UvrY,  and YhhP) belongs to a family of a two-component response...; Region: SirA_like_N; cd03421
243231008143	selenium metabolism protein YedF; Region: selenium_YedF; TIGR03527
243231008144	CPxP  motif; other site
243231008145	putative DNA-binding transcriptional regulator; Provisional; Region: PRK10837
243231008146	Helix-turn-helix domains; Region: HTH; cl00088
243231008147	C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420
243231008148	putative dimerization interface [polypeptide binding]; other site
243231008149	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
243231008150	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
243231008151	active site
243231008152	phosphorylation site [posttranslational modification]
243231008153	intermolecular recognition site; other site
243231008154	dimerization interface [polypeptide binding]; other site
243231008155	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
243231008156	Walker A motif; other site
243231008157	ATP binding site [chemical binding]; other site
243231008158	Walker B motif; other site
243231008159	arginine finger; other site
243231008160	Helix-turn-helix domains; Region: HTH; cl00088
243231008161	NAD(P)H:flavin oxidoreductase-like family 1.  A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes; Region: NADPH_oxidoreductase_1; cd02150
243231008162	putative FMN binding site [chemical binding]; other site
243231008163	Sulfite reductase, beta subunit (hemoprotein) [Inorganic ion transport and metabolism]; Region: CysI; COG0155
243231008164	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
243231008165	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
243231008166	FecR protein; Region: FecR; pfam04773
243231008167	elongation factor G; Reviewed; Region: PRK13351
243231008168	Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886
243231008169	G1 box; other site
243231008170	putative GEF interaction site [polypeptide binding]; other site
243231008171	GTP/Mg2+ binding site [chemical binding]; other site
243231008172	Switch I region; other site
243231008173	G2 box; other site
243231008174	G3 box; other site
243231008175	Switch II region; other site
243231008176	G4 box; other site
243231008177	G5 box; other site
243231008178	EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088
243231008179	Elongation Factor G-like domain IV. This family includes the translational elongation factor termed EF-2 (for Archaea and Eukarya) and EF-G (for Bacteria), ribosomal protection proteins that mediate tetracycline resistance and, an evolutionarily...; Region: EFG_like_IV; cd01680
243231008180	EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G.  Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713
243231008181	GTPase RsgA; Reviewed; Region: PRK01889
243231008182	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
243231008183	RNA binding site [nucleotide binding]; other site
243231008184	Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854
243231008185	GTPase/Zn-binding domain interface [polypeptide binding]; other site
243231008186	GTP/Mg2+ binding site [chemical binding]; other site
243231008187	G4 box; other site
243231008188	G5 box; other site
243231008189	G1 box; other site
243231008190	Switch I region; other site
243231008191	G2 box; other site
243231008192	G3 box; other site
243231008193	Switch II region; other site
243231008194	Signal transduction histidine kinase involved in nitrogen fixation and metabolism regulation [Signal transduction mechanisms]; Region: NtrY; COG5000
243231008195	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054
243231008196	PAS domain S-box; Region: sensory_box; TIGR00229
243231008197	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
243231008198	putative active site [active]
243231008199	heme pocket [chemical binding]; other site
243231008200	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459
243231008201	PAS domain; Region: PAS_9; pfam13426
243231008202	GAF domain; Region: GAF_2; pfam13185
243231008203	GAF domain; Region: GAF; cl15785
243231008204	PAS domain S-box; Region: sensory_box; TIGR00229
243231008205	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
243231008206	putative active site [active]
243231008207	heme pocket [chemical binding]; other site
243231008208	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
243231008209	dimer interface [polypeptide binding]; other site
243231008210	phosphorylation site [posttranslational modification]
243231008211	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
243231008212	ATP binding site [chemical binding]; other site
243231008213	Mg2+ binding site [ion binding]; other site
243231008214	G-X-G motif; other site
243231008215	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
243231008216	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
243231008217	active site
243231008218	Response regulator containing a CheY-like receiver domain and a GGDEF domain [Signal transduction mechanisms]; Region: PleD; COG3706
243231008219	phosphorylation site [posttranslational modification]
243231008220	intermolecular recognition site; other site
243231008221	dimerization interface [polypeptide binding]; other site
243231008222	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459
243231008223	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
243231008224	metal binding site [ion binding]; metal-binding site
243231008225	active site
243231008226	I-site; other site
243231008227	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
243231008228	active site
243231008229	phosphorylation site [posttranslational modification]
243231008230	intermolecular recognition site; other site
243231008231	dimerization interface [polypeptide binding]; other site
243231008232	Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412
243231008233	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
243231008234	arginine decarboxylase; Provisional; Region: PRK05354
243231008235	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Arginine Decarboxylase; Region: PLPDE_III_ADC; cd06830
243231008236	active site
243231008237	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
243231008238	catalytic residues [active]
243231008239	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261
243231008240	carboxynorspermidine decarboxylase; Region: nspC; TIGR01047
243231008241	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Carboxynorspermidine Decarboxylase; Region: PLPDE_III_CANSDC; cd06829
243231008242	dimer interface [polypeptide binding]; other site
243231008243	active site
243231008244	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
243231008245	catalytic residues [active]
243231008246	substrate binding site [chemical binding]; other site
243231008247	Saccharopine dehydrogenase and related proteins [Amino acid transport and metabolism]; Region: LYS9; COG1748
243231008248	DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943
243231008249	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
243231008250	non-specific DNA binding site [nucleotide binding]; other site
243231008251	salt bridge; other site
243231008252	sequence-specific DNA binding site [nucleotide binding]; other site
243231008253	Cupin domain; Region: Cupin_2; cl09118
243231008254	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
243231008255	pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880
243231008256	Putative catalytic NodB homology domain of PgaB, IcaB, and similar proteins which consist of a deformed (beta/alpha)8 barrel fold with 5- or 6-strands; Region: CE4_NodB_like_5s_6s; cd10918
243231008257	putative active site [active]
243231008258	putative metal binding site [ion binding]; other site
243231008259	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635
243231008260	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
243231008261	catalytic residue [active]
243231008262	Maf-like protein; Region: Maf; pfam02545
243231008263	Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555
243231008264	active site
243231008265	dimer interface [polypeptide binding]; other site
243231008266	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
243231008267	NAD(FAD)-utilizing enzyme possibly involved in translation [Translation, ribosomal structure and biogenesis]; Region: Gid; COG1206
243231008268	DNA topoisomerase I; Validated; Region: PRK06599
243231008269	TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I.   Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363
243231008270	active site
243231008271	interdomain interaction site; other site
243231008272	putative metal-binding site [ion binding]; other site
243231008273	nucleotide binding site [chemical binding]; other site
243231008274	DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186
243231008275	domain I; other site
243231008276	DNA binding groove [nucleotide binding]
243231008277	phosphate binding site [ion binding]; other site
243231008278	domain II; other site
243231008279	domain III; other site
243231008280	nucleotide binding site [chemical binding]; other site
243231008281	catalytic site [active]
243231008282	domain IV; other site
243231008283	Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396
243231008284	Zn-finger domain associated with topoisomerase type I [DNA replication, recombination, and repair]; Region: TopA; COG0551
243231008285	Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396
243231008286	Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396
243231008287	Hef nuclease; Provisional; Region: PRK13766
243231008288	DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481
243231008289	Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695
243231008290	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
243231008291	tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795
243231008292	Tetratricopeptide repeat; Region: TPR_6; pfam13174
243231008293	Tetratricopeptide repeat; Region: TPR_6; pfam13174
243231008294	Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187
243231008295	Ligand binding site; other site
243231008296	Putative Catalytic site; other site
243231008297	DXD motif; other site
243231008298	Lipid A Biosynthesis N-terminal domain; Region: LAB_N; cl01627
243231008299	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807
243231008300	Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl15769
243231008301	putative protease; Provisional; Region: PRK15452
243231008302	Peptidase family U32; Region: Peptidase_U32; cl03113
243231008303	Catalytic domain of Escherichia coli 4-deoxy-4-formamido-L-arabinose-phosphoundecaprenol deformylase ArnD and other bacterial homologs; Region: CE4_ArnD; cd10939
243231008304	4-deoxy-4-formamido-L-arabinose-phosphoundecaprenol deformylase ArnD; Provisional; Region: PRK15394
243231008305	putative active site [active]
243231008306	putative catalytic site [active]
243231008307	putative Zn binding site [ion binding]; other site
243231008308	Uncharacterized ACR, YagE family COG1723; Region: DUF155; cl00751
243231008309	Exopolyphosphatase [Nucleotide transport and metabolism / Inorganic ion transport and metabolism]; Region: GppA; COG0248
243231008310	Ppx/GppA phosphatase family; Region: Ppx-GppA; cl15449
243231008311	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
243231008312	Zn2+ binding site [ion binding]; other site
243231008313	Mg2+ binding site [ion binding]; other site
243231008314	CHAD domain; Region: CHAD; cl10506
243231008315	DNA repair and recombination protein RadA; Validated; Region: radA; PRK04301
243231008316	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
243231008317	catalytic core [active]
243231008318	Flagellin N-methylase; Region: FliB; cl00497
243231008319	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
243231008320	dimer interface [polypeptide binding]; other site
243231008321	phosphorylation site [posttranslational modification]
243231008322	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
243231008323	ATP binding site [chemical binding]; other site
243231008324	Mg2+ binding site [ion binding]; other site
243231008325	G-X-G motif; other site
243231008326	Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal transduction mechanisms]; Region: COG4191
243231008327	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
243231008328	dimerization interface [polypeptide binding]; other site
243231008329	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
243231008330	dimer interface [polypeptide binding]; other site
243231008331	phosphorylation site [posttranslational modification]
243231008332	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
243231008333	ATP binding site [chemical binding]; other site
243231008334	Mg2+ binding site [ion binding]; other site
243231008335	G-X-G motif; other site
243231008336	Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919
243231008337	MiaB-like tRNA modifying enzyme; Region: MiaB-like-C; TIGR01579
243231008338	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
243231008339	FeS/SAM binding site; other site
243231008340	tRNA methyl transferase; Region: tRNA_Me_trans; pfam03054
243231008341	tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998
243231008342	Ligand Binding Site [chemical binding]; other site
243231008343	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
243231008344	cysteine desulfurase DndA; Region: DNA_S_dndA; TIGR03235
243231008345	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
243231008346	catalytic residue [active]
243231008347	Helix-turn-helix domains; Region: HTH; cl00088
243231008348	Rrf2 family protein; Region: rrf2_super; TIGR00738
243231008349	serine O-acetyltransferase; Region: cysE; TIGR01172
243231008350	Serine acetyltransferase, N-terminal; Region: SATase_N; cl05762
243231008351	Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354
243231008352	trimer interface [polypeptide binding]; other site
243231008353	active site
243231008354	substrate binding site [chemical binding]; other site
243231008355	CoA binding site [chemical binding]; other site
243231008356	Response regulator containing a CheY-like receiver domain and an HD-GYP domain [Transcription / Signal transduction mechanisms]; Region: COG3437
243231008357	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
243231008358	active site
243231008359	phosphorylation site [posttranslational modification]
243231008360	intermolecular recognition site; other site
243231008361	dimerization interface [polypeptide binding]; other site
243231008362	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
243231008363	Zn2+ binding site [ion binding]; other site
243231008364	Mg2+ binding site [ion binding]; other site
243231008365	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
243231008366	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
243231008367	dimer interface [polypeptide binding]; other site
243231008368	phosphorylation site [posttranslational modification]
243231008369	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
243231008370	ATP binding site [chemical binding]; other site
243231008371	Mg2+ binding site [ion binding]; other site
243231008372	G-X-G motif; other site
243231008373	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
243231008374	Response regulator receiver domain; Region: Response_reg; pfam00072
243231008375	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
243231008376	active site
243231008377	phosphorylation site [posttranslational modification]
243231008378	intermolecular recognition site; other site
243231008379	dimerization interface [polypeptide binding]; other site
243231008380	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cl00086
243231008381	HDOD domain; Region: HDOD; pfam08668
243231008382	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076
243231008383	CheW, a small regulator protein, unique to the chemotaxis signalling in prokaryotes and archea. CheW interacts with the histidine kinase CheA, most likely with the related regulatory domain of CheA. CheW is proposed to form signalling arrays together...; Region: CheW; cd00732
243231008384	putative CheA interaction surface; other site
243231008385	Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729
243231008386	ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cl00144
243231008387	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
243231008388	dimerization interface [polypeptide binding]; other site
243231008389	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
243231008390	dimer interface [polypeptide binding]; other site
243231008391	putative CheW interface [polypeptide binding]; other site
243231008392	Ribosomally synthesized peptide prototyped by Frankia Franean1_4349; Region: Frankia_peptide; pfam14407
243231008393	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
243231008394	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
243231008395	active site
243231008396	phosphorylation site [posttranslational modification]
243231008397	intermolecular recognition site; other site
243231008398	dimerization interface [polypeptide binding]; other site
243231008399	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
243231008400	Walker A motif; other site
243231008401	ATP binding site [chemical binding]; other site
243231008402	Walker B motif; other site
243231008403	arginine finger; other site
243231008404	Helix-turn-helix domains; Region: HTH; cl00088
243231008405	Isochorismatase family; Region: Isochorismatase; pfam00857
243231008406	YcaC related amidohydrolases; E.coli YcaC is an homooctameric hydrolase with unknown specificity. Despite its weak sequence similarity, it is structurally related to other amidohydrolases and shares conserved active site residues with them; Region: YcaC_related; cd01012
243231008407	catalytic triad [active]
243231008408	dimer interface [polypeptide binding]; other site
243231008409	conserved cis-peptide bond; other site
243231008410	Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396
243231008411	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
243231008412	Helix-turn-helix domains; Region: HTH; cl00088
243231008413	Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes [Energy production and conversion]; Region: Lpd; COG1249
243231008414	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
243231008415	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
243231008416	Restriction endonuclease; Region: Mrr_cat; cl00516
243231008417	Transposase; Region: DEDD_Tnp_IS110; pfam01548
243231008418	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
243231008419	TIR domain; Region: TIR_2; cl15770
243231008420	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584
243231008421	Integrase core domain; Region: rve; cl01316
243231008422	transposase/IS protein; Provisional; Region: PRK09183
243231008423	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
243231008424	Walker A motif; other site
243231008425	ATP binding site [chemical binding]; other site
243231008426	Walker B motif; other site
243231008427	Transposase domain (DUF772); Region: DUF772; pfam05598
243231008428	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
243231008429	DDE superfamily endonuclease; Region: DDE_4; cl15789
243231008430	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
243231008431	Transposase; Region: DEDD_Tnp_IS110; pfam01548
243231008432	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
243231008433	SEC-C motif; Region: SEC-C; pfam02810
243231008434	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
243231008435	TPR motif; other site
243231008436	binding surface
243231008437	Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones]; Region: Spy; COG3914
243231008438	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
243231008439	binding surface
243231008440	TPR motif; other site
243231008441	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
243231008442	IHF dimer interface [polypeptide binding]; other site
243231008443	IHF - DNA interface [nucleotide binding]; other site
243231008444	30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06299
243231008445	S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec1_hs1; cd05687
243231008446	RNA binding site [nucleotide binding]; other site
243231008447	S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec2_hs2; cd04465
243231008448	RNA binding site [nucleotide binding]; other site
243231008449	S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists of...; Region: S1_RPS1_repeat_ec3; cd05688
243231008450	RNA binding site [nucleotide binding]; other site
243231008451	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
243231008452	RNA binding site [nucleotide binding]; other site
243231008453	S1_RPS1_repeat_ec5: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists of...; Region: S1_RPS1_repeat_ec5; cd05690
243231008454	RNA binding site [nucleotide binding]; other site
243231008455	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
243231008456	RNA binding site [nucleotide binding]; other site
243231008457	LytB protein; Region: LYTB; cl00507
243231008458	(E)-4-hydroxy-3-methyl-but-2-enyl pyrophosphate reductase (IPP and DMAPP forming); Region: ispH_lytB; TIGR00216
243231008459	cytidylate kinase; Provisional; Region: cmk; PRK00023
243231008460	Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020
243231008461	CMP-binding site; other site
243231008462	The sites determining sugar specificity; other site
243231008463	EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556
243231008464	3-phosphoshikimate 1-carboxyvinyltransferase; Region: aroA; TIGR01356
243231008465	hinge; other site
243231008466	active site
243231008467	cyclohexadienyl dehydrogenase; Validated; Region: PRK07502
243231008468	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
243231008469	Chorismate mutase type II; Region: CM_2; cl00693
243231008470	prephenate dehydratase; Provisional; Region: PRK11898
243231008471	Prephenate dehydratase; Region: PDT; pfam00800
243231008472	C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905
243231008473	putative L-Phe binding site [chemical binding]; other site
243231008474	type IV-A pilus assembly ATPase PilB; Region: type_IV_pilB; TIGR02538
243231008475	type IV-A pilus assembly ATPase PilB; Region: type_IV_pilB; TIGR02538
243231008476	Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157
243231008477	PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129
243231008478	Walker A motif; other site
243231008479	ATP binding site [chemical binding]; other site
243231008480	Walker B motif; other site
243231008481	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cl00107
243231008482	Rubrerythrin, ferritin-like diiron-binding domain; Region: Rubrerythrin; cd01041
243231008483	Rubrerythrin [Energy production and conversion]; Region: COG1592
243231008484	binuclear metal center [ion binding]; other site
243231008485	Rubredoxin, Small Modular nonheme iron binding domain containing a [Fe(SCys)4] center, present in rubrerythrin and nigerythrin and detected either N- or C-terminal to such proteins as flavin reductase, NAD(P)H-nitrite reductase, and...; Region: rubredoxin_SM; cd00729
243231008486	iron binding site [ion binding]; other site
243231008487	Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053
243231008488	Cation efflux family; Region: Cation_efflux; cl00316
243231008489	single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644
243231008490	DHH family; Region: DHH; pfam01368
243231008491	DHHA1 domain; Region: DHHA1; pfam02272
243231008492	TPR repeat; Region: TPR_11; pfam13414
243231008493	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
243231008494	binding surface
243231008495	TPR motif; other site
243231008496	Tetratricopeptide repeat; Region: TPR_12; pfam13424
243231008497	preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022
243231008498	Protein export membrane protein; Region: SecD_SecF; cl14618
243231008499	preprotein translocase subunit SecD; Reviewed; Region: secD; PRK05812
243231008500	SecD/SecF GG Motif; Region: Sec_GG; pfam07549
243231008501	Protein export membrane protein; Region: SecD_SecF; cl14618
243231008502	Preprotein translocase subunit; Region: YajC; cl00806
243231008503	queuine tRNA-ribosyltransferase; Provisional; Region: tgt; cl00409
243231008504	tRNA-guanine transglycosylases, various specificities; Region: tgt_general; TIGR00449
243231008505	S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147
243231008506	Queuosine biosynthesis protein; Region: Queuosine_synth; cl00523
243231008507	Stage II sporulation protein; Region: SpoIID; pfam08486
243231008508	SpoIID/LytB domain; Region: SpoIID_LytB; TIGR02669
243231008509	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: VicK; COG5002
243231008510	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054
243231008511	GAF domain; Region: GAF_2; pfam13185
243231008512	GAF domain; Region: GAF; cl15785
243231008513	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
243231008514	Zn2+ binding site [ion binding]; other site
243231008515	Mg2+ binding site [ion binding]; other site
243231008516	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444
243231008517	The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE).  The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257
243231008518	Walker A/P-loop; other site
243231008519	ATP binding site [chemical binding]; other site
243231008520	Q-loop/lid; other site
243231008521	ABC transporter signature motif; other site
243231008522	Walker B; other site
243231008523	D-loop; other site
243231008524	H-loop/switch region; other site
243231008525	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
243231008526	dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308
243231008527	The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE).  The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257
243231008528	Walker A/P-loop; other site
243231008529	ATP binding site [chemical binding]; other site
243231008530	Q-loop/lid; other site
243231008531	ABC transporter signature motif; other site
243231008532	Walker B; other site
243231008533	D-loop; other site
243231008534	H-loop/switch region; other site
243231008535	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
243231008536	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
243231008537	dimerization interface [polypeptide binding]; other site
243231008538	putative DNA binding site [nucleotide binding]; other site
243231008539	putative Zn2+ binding site [ion binding]; other site
243231008540	PUA domain; Region: PUA; cl00607
243231008541	Predicted SAM-dependent methyltransferases [General function prediction only]; Region: COG1092
243231008542	Middle domain of the SAM-dependent methyltransferase RlmI and related proteins; Region: RlmI_M_like; cd11572
243231008543	putative RNA binding site [nucleotide binding]; other site
243231008544	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
243231008545	S-adenosylmethionine binding site [chemical binding]; other site
243231008546	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911
243231008547	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
243231008548	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
243231008549	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
243231008550	7-keto-8-aminopelargonate synthetase and related enzymes [Coenzyme metabolism]; Region: BioF; COG0156
243231008551	KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454
243231008552	substrate-cofactor binding pocket; other site
243231008553	pyridoxal 5'-phosphate binding site [chemical binding]; other site
243231008554	catalytic residue [active]
243231008555	phosphoprotein phosphatases of the metallophosphatase superfamily, metallophosphatase domain; Region: MPP_PPP_family; cd00144
243231008556	active site
243231008557	metal binding site [ion binding]; metal-binding site
243231008558	Uncharacterized protein family UPF0047; Region: UPF0047; cl00439
243231008559	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
243231008560	metal binding site [ion binding]; metal-binding site
243231008561	active site
243231008562	I-site; other site
243231008563	The ML (MD-2-related lipid-recognition) domain is present in MD-1, MD-2, GM2 activator protein, Niemann-Pick type C2 (Npc2) protein, phosphatidylinositol/phosphatidylglycerol transfer protein (PG/PI-TP), mite allergen Der p 2  and several proteins of...; Region: ML; cl00274
243231008564	Hemerythrin (Hr) is a non-heme diiron oxygen transport protein found in four marine invertebrate phyla including priapulida, brachiopoda, sipunculida, and annelida, as well as in protozoa. Myohemerythrin (Mhr), a hemerythrin homolog, is found in the...; Region: Hemerythrin; cl15774
243231008565	octamerization interface [polypeptide binding]; other site
243231008566	diferric-oxygen binding site [ion binding]; other site
243231008567	Alpha amylase catalytic domain found in an uncharacterized protein family; Region: AmyAc_5; cd11352
243231008568	active site
243231008569	catalytic site [active]
243231008570	putative NAD(P)H quinone oxidoreductase, PIG3 family; Region: quinone_pig3; TIGR02824
243231008571	PIG3 p53-inducible quinone oxidoreductase; Region: p53_inducible_oxidoreductase; cd05276
243231008572	NAD(P) binding site [chemical binding]; other site
243231008573	Protein of unknown function (DUF456); Region: DUF456; cl01069
243231008574	Axonemal dynein light chain; Region: Ax_dynein_light; pfam10211
243231008575	Domain of unknown function (DUF4388); Region: DUF4388; pfam14332
243231008576	Roadblock/LC7 domain; Region: Robl_LC7; cl00886
243231008577	decaheme c-type cytochrome, DmsE family; Region: decahem_SO; TIGR03508
243231008578	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
243231008579	atypical (a) SDRs, subgroup 4; Region: SDR_a4; cd05266
243231008580	putative NAD(P) binding site [chemical binding]; other site
243231008581	Uncharacterized protein family, UPF0114; Region: UPF0114; cl01078
243231008582	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
243231008583	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
243231008584	substrate binding pocket [chemical binding]; other site
243231008585	membrane-bound complex binding site; other site
243231008586	hinge residues; other site
243231008587	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
243231008588	dimer interface [polypeptide binding]; other site
243231008589	conserved gate region; other site
243231008590	putative PBP binding loops; other site
243231008591	ABC-ATPase subunit interface; other site
243231008592	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
243231008593	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
243231008594	Walker A/P-loop; other site
243231008595	ATP binding site [chemical binding]; other site
243231008596	Q-loop/lid; other site
243231008597	ABC transporter signature motif; other site
243231008598	Walker B; other site
243231008599	D-loop; other site
243231008600	H-loop/switch region; other site
243231008601	PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474
243231008602	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054
243231008603	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
243231008604	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
243231008605	dimer interface [polypeptide binding]; other site
243231008606	putative CheW interface [polypeptide binding]; other site
243231008607	Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534
243231008608	MatE; Region: MatE; cl10513
243231008609	MatE; Region: MatE; cl10513
243231008610	pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_x; TIGR03181
243231008611	Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000
243231008612	TPP-binding site [chemical binding]; other site
243231008613	tetramer interface [polypeptide binding]; other site
243231008614	heterodimer interface [polypeptide binding]; other site
243231008615	phosphorylation loop region [posttranslational modification]
243231008616	Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022
243231008617	Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036
243231008618	alpha subunit interface [polypeptide binding]; other site
243231008619	TPP binding site [chemical binding]; other site
243231008620	heterodimer interface [polypeptide binding]; other site
243231008621	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
243231008622	branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856
243231008623	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
243231008624	E3 interaction surface; other site
243231008625	lipoyl attachment site [posttranslational modification]; other site
243231008626	e3 binding domain; Region: E3_binding; pfam02817
243231008627	2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; cl02008
243231008628	multicopper oxidase; Provisional; Region: PRK10965
243231008629	Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; cl11412
243231008630	Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; cl11412
243231008631	Domain of unknown function (DUF1858); Region: DUF1858; cl14817
243231008632	Hemerythrin (Hr) is a non-heme diiron oxygen transport protein found in four marine invertebrate phyla including priapulida, brachiopoda, sipunculida, and annelida, as well as in protozoa. Myohemerythrin (Mhr), a hemerythrin homolog, is found in the...; Region: Hemerythrin; cl15774
243231008633	zinc-ribbon domain; Region: zinc_ribbon_5; cl11777
243231008634	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
243231008635	Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538
243231008636	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
243231008637	Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404
243231008638	Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404
243231008639	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
243231008640	Helix-turn-helix domains; Region: HTH; cl00088
243231008641	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
243231008642	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
243231008643	putative active site [active]
243231008644	heme pocket [chemical binding]; other site
243231008645	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
243231008646	dimer interface [polypeptide binding]; other site
243231008647	phosphorylation site [posttranslational modification]
243231008648	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
243231008649	ATP binding site [chemical binding]; other site
243231008650	Mg2+ binding site [ion binding]; other site
243231008651	G-X-G motif; other site
243231008652	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
243231008653	dimer interface [polypeptide binding]; other site
243231008654	phosphorylation site [posttranslational modification]
243231008655	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
243231008656	ATP binding site [chemical binding]; other site
243231008657	G-X-G motif; other site
243231008658	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
243231008659	DNA binding residues [nucleotide binding]
243231008660	dimerization interface [polypeptide binding]; other site
243231008661	Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199
243231008662	AFG1-like ATPase; Region: AFG1_ATPase; pfam03969
243231008663	C1 Peptidase family (MEROPS database nomenclature), also referred to as the papain family; composed of two subfamilies of cysteine peptidases (CPs), C1A (papain) and C1B (bleomycin hydrolase). Papain-like enzymes are mostly endopeptidases with some...; Region: Peptidase_C1; cd02619
243231008664	active site
243231008665	Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950
243231008666	Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950
243231008667	EamA-like transporter family; Region: EamA; cl01037
243231008668	Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071
243231008669	Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain  (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464
243231008670	putative dimer interface [polypeptide binding]; other site
243231008671	Protein of unknown function, DUF606; Region: DUF606; cl01273
243231008672	Predicted membrane protein (DUF2127); Region: DUF2127; cl01785
243231008673	Polyferredoxin [Energy production and conversion]; Region: NapH; COG0348
243231008674	4Fe-4S binding domain; Region: Fer4_5; pfam12801
243231008675	quinol dehydrogenase periplasmic component; Provisional; Region: napG; PRK09476
243231008676	4Fe-4S binding domain; Region: Fer4; cl02805
243231008677	Uncharacterized conserved protein [Function unknown]; Region: COG2006
243231008678	Domain of unknown function (DUF362); Region: DUF362; pfam04015
243231008679	2-dehydropantoate 2-reductase; Provisional; Region: PRK06249
243231008680	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
243231008681	Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546
243231008682	Predicted membrane protein [Function unknown]; Region: COG1511
243231008683	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
243231008684	ABC-2 type transporter; Region: ABC2_membrane; cl11417
243231008685	ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123
243231008686	This family of ATP-binding proteins belongs to a multisubunit transporter involved in drug resistance (BcrA and DrrA), nodulation, lipid transport, and lantibiotic immunity.  In bacteria and archaea, these transporters usually include an ATP-binding...; Region: ABC_DR_subfamily_A; cd03230
243231008687	Walker A/P-loop; other site
243231008688	ATP binding site [chemical binding]; other site
243231008689	Q-loop/lid; other site
243231008690	ABC transporter signature motif; other site
243231008691	Walker B; other site
243231008692	D-loop; other site
243231008693	H-loop/switch region; other site
243231008694	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
243231008695	Walker A/P-loop; other site
243231008696	ATP binding site [chemical binding]; other site
243231008697	Q-loop/lid; other site
243231008698	ABC transporter signature motif; other site
243231008699	Walker B; other site
243231008700	D-loop; other site
243231008701	H-loop/switch region; other site
243231008702	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
243231008703	ABC-2 type transporter; Region: ABC2_membrane; cl11417
243231008704	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
243231008705	putative efflux pump membrane fusion protein; Provisional; Region: PRK03598
243231008706	Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404
243231008707	VacJ like lipoprotein; Region: VacJ; cl01073
243231008708	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
243231008709	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
243231008710	NMT1-like family; Region: NMT1_2; cl15260
243231008711	TRAP-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: Imp; COG2358
243231008712	Response regulator receiver domain; Region: Response_reg; pfam00072
243231008713	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
243231008714	active site
243231008715	phosphorylation site [posttranslational modification]
243231008716	intermolecular recognition site; other site
243231008717	dimerization interface [polypeptide binding]; other site
243231008718	copper/silver efflux system outer membrane protein CusC; Provisional; Region: PRK09837
243231008719	The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915
243231008720	Protein export membrane protein; Region: SecD_SecF; cl14618
243231008721	multidrug efflux system transporter AcrA; Provisional; Region: PRK15030
243231008722	Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404
243231008723	Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404
243231008724	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
243231008725	Helix-turn-helix domains; Region: HTH; cl00088
243231008726	MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cl00399
243231008727	MoaE homodimer interface [polypeptide binding]; other site
243231008728	MoaD interaction [polypeptide binding]; other site
243231008729	active site residues [active]
243231008730	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
243231008731	Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531
243231008732	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
243231008733	dimer interface [polypeptide binding]; other site
243231008734	conserved gate region; other site
243231008735	putative PBP binding loops; other site
243231008736	ABC-ATPase subunit interface; other site
243231008737	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
243231008738	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
243231008739	Walker A/P-loop; other site
243231008740	ATP binding site [chemical binding]; other site
243231008741	Q-loop/lid; other site
243231008742	ABC transporter signature motif; other site
243231008743	Walker B; other site
243231008744	D-loop; other site
243231008745	H-loop/switch region; other site
243231008746	Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303
243231008747	MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887
243231008748	dimer interface [polypeptide binding]; other site
243231008749	putative functional site; other site
243231008750	putative MPT binding site; other site
243231008751	MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420
243231008752	trimer interface [polypeptide binding]; other site
243231008753	dimer interface [polypeptide binding]; other site
243231008754	putative active site [active]
243231008755	MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886
243231008756	MPT binding site; other site
243231008757	trimer interface [polypeptide binding]; other site
243231008758	Phosphate acetyl/butaryl transferase; Region: PTA_PTB; cl00390
243231008759	Phosphotransacetylase [Energy production and conversion]; Region: Pta; COG0280
243231008760	Acetokinase family; Region: Acetate_kinase; cl01029
243231008761	acetate kinase; Region: ackA; TIGR00016
243231008762	hypothetical protein; Provisional; Region: PRK13795
243231008763	4Fe-4S binding domain; Region: Fer4; cl02805
243231008764	Protein of unknown function (DUF3426); Region: DUF3426; pfam11906
243231008765	Protein of unknown function (DUF1573); Region: DUF1573; pfam07610
243231008766	Protein of unknown function (DUF1573); Region: DUF1573; pfam07610
243231008767	Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446
243231008768	delta-60 repeat domain; Region: delta_60_rpt; TIGR02608
243231008769	delta-60 repeat domain; Region: delta_60_rpt; TIGR02608
243231008770	delta-60 repeat domain; Region: delta_60_rpt; TIGR02608
243231008771	delta-60 repeat domain; Region: delta_60_rpt; TIGR02608
243231008772	delta-60 repeat domain; Region: delta_60_rpt; TIGR02608
243231008773	Listeria-Bacteroides repeat domain (List_Bact_rpt); Region: Flg_new; cl09714
243231008774	Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063
243231008775	Interdomain contacts; other site
243231008776	Cytokine receptor motif; other site
243231008777	Sugar fermentation stimulation protein; Region: SfsA; cl00647
243231008778	Hydrogenase specific C-terminal endopeptidases, also called Hydrogen Maturation Proteases (H2MP). These enzymes belong to the peptidase family M52. Maturation of [FeNi] hydrogenases includes formation of the nickel metallocenter, proteolytic processing...; Region: H2MP; cl00477
243231008779	nickel binding site [ion binding]; other site
243231008780	Nickel-dependent hydrogenase; Region: NiFeSe_Hases; cl00417
243231008781	NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; cl15792
243231008782	bidirectional hydrogenase complex protein HoxU; Validated; Region: PRK07569
243231008783	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cl00159
243231008784	NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; cl11210
243231008785	4Fe-4S binding domain; Region: Fer4; cl02805
243231008786	Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980
243231008787	dimer interface [polypeptide binding]; other site
243231008788	[2Fe-2S] cluster binding site [ion binding]; other site
243231008789	NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit [Energy production and conversion]; Region: NuoF; COG1894
243231008790	SLBB domain; Region: SLBB; pfam10531
243231008791	NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; cl11211
243231008792	Respiratory-chain NADH dehydrogenase 24 Kd subunit; Region: Complex1_24kDa; pfam01257
243231008793	TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064
243231008794	putative dimer interface [polypeptide binding]; other site
243231008795	[2Fe-2S] cluster binding site [ion binding]; other site
243231008796	TMAO/DMSO reductase; Reviewed; Region: PRK05363
243231008797	YedY_like molybdopterin cofactor (Moco) binding domain, a subgroup of the sulfite oxidase (SO) family of molybdopterin binding domains. Escherichia coli YedY has been propsed to form a heterodimer, consisting of a soluble catalytic subunit termed YedY; Region: YedY_like_Moco; cd02107
243231008798	Moco binding site; other site
243231008799	metal coordination site [ion binding]; other site
243231008800	Protein of unknown function (DUF3108); Region: DUF3108; pfam11306
243231008801	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
243231008802	Helix-turn-helix domains; Region: HTH; cl00088
243231008803	decaheme c-type cytochrome, DmsE family; Region: decahem_SO; TIGR03508
243231008804	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
243231008805	Helix-turn-helix domains; Region: HTH; cl00088
243231008806	Cytochrome c; Region: Cytochrom_C; cl11414
243231008807	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
243231008808	Major Facilitator Superfamily; Region: MFS_1; pfam07690
243231008809	putative substrate translocation pore; other site
243231008810	Ycf46; Provisional; Region: ycf46; CHL00195
243231008811	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
243231008812	Walker A motif; other site
243231008813	ATP binding site [chemical binding]; other site
243231008814	Walker B motif; other site
243231008815	arginine finger; other site
243231008816	Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600
243231008817	Zinc ribbon domain; Region: CxxC_CxxC_SSSS; cl00993
243231008818	NOL1/NOP2/sun family; Region: Nol1_Nop2_Fmu; pfam01189
243231008819	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911
243231008820	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
243231008821	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl09944
243231008822	Anaerobic c4-dicarboxylate membrane transporter; Region: DcuA_DcuB; cl01040
243231008823	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
243231008824	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
243231008825	active site
243231008826	phosphorylation site [posttranslational modification]
243231008827	intermolecular recognition site; other site
243231008828	dimerization interface [polypeptide binding]; other site
243231008829	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
243231008830	Walker A motif; other site
243231008831	ATP binding site [chemical binding]; other site
243231008832	Walker B motif; other site
243231008833	arginine finger; other site
243231008834	Helix-turn-helix domains; Region: HTH; cl00088
243231008835	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
243231008836	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
243231008837	substrate binding pocket [chemical binding]; other site
243231008838	membrane-bound complex binding site; other site
243231008839	hinge residues; other site
243231008840	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080
243231008841	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
243231008842	ATP binding site [chemical binding]; other site
243231008843	Mg2+ binding site [ion binding]; other site
243231008844	G-X-G motif; other site
243231008845	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cl02542
243231008846	Excinuclease ATPase subunit [DNA replication, recombination, and repair]; Region: UvrA; COG0178
243231008847	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
243231008848	Walker A/P-loop; other site
243231008849	ATP binding site [chemical binding]; other site
243231008850	Q-loop/lid; other site
243231008851	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
243231008852	ABC transporter signature motif; other site
243231008853	Walker B; other site
243231008854	D-loop; other site
243231008855	H-loop/switch region; other site
243231008856	The excision repair protein UvrA domain II; Nucleotide excision repair in eubacteria is a process that repairs DNA damage by the removal of a 12-13-mer oligonucleotide containing the lesion.  Recognition and cleavage of the damaged DNA is a multistep...; Region: ABC_UvrA_II; cd03271
243231008857	excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349
243231008858	The excision repair protein UvrA domain I; Nucleotide excision repair in eubacteria is a process that repairs DNA damage by the removal of a 12-13-mer oligonucleotide containing the lesion.  Recognition and cleavage of the damaged DNA is a multistep...; Region: ABC_UvrA_I; cd03270
243231008859	Excinuclease ATPase subunit [DNA replication, recombination, and repair]; Region: UvrA; COG0178
243231008860	The excision repair protein UvrA domain I; Nucleotide excision repair in eubacteria is a process that repairs DNA damage by the removal of a 12-13-mer oligonucleotide containing the lesion.  Recognition and cleavage of the damaged DNA is a multistep...; Region: ABC_UvrA_I; cd03270
243231008861	The excision repair protein UvrA domain II; Nucleotide excision repair in eubacteria is a process that repairs DNA damage by the removal of a 12-13-mer oligonucleotide containing the lesion.  Recognition and cleavage of the damaged DNA is a multistep...; Region: ABC_UvrA_II; cd03271
243231008862	glutathione-regulated potassium-efflux system protein KefC; Provisional; Region: PRK03562
243231008863	Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482
243231008864	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
243231008865	NADPH-dependent FMN reductase; Region: FMN_red; cl00438
243231008866	glycerol-3-phosphate dehydrogenase; Region: PLN02464
243231008867	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
243231008868	glycerol kinase; Provisional; Region: glpK; PRK00047
243231008869	Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786
243231008870	N- and C-terminal domain interface [polypeptide binding]; other site
243231008871	active site
243231008872	MgATP binding site [chemical binding]; other site
243231008873	catalytic site [active]
243231008874	metal binding site [ion binding]; metal-binding site
243231008875	glycerol binding site [chemical binding]; other site
243231008876	homotetramer interface [polypeptide binding]; other site
243231008877	homodimer interface [polypeptide binding]; other site
243231008878	FBP binding site [chemical binding]; other site
243231008879	protein IIAGlc interface [polypeptide binding]; other site
243231008880	Protein of unknown function (DUF1003); Region: DUF1003; cl01831
243231008881	Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695
243231008882	cytochrome c nitrate reductase, small subunit; Region: cytochr_NrfH; TIGR03153
243231008883	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
243231008884	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cd00838
243231008885	active site
243231008886	metal binding site [ion binding]; metal-binding site
243231008887	Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446
243231008888	Transposase IS200 like; Region: Y1_Tnp; cl00848
243231008889	C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571
243231008890	DnaA box-binding interface [nucleotide binding]; other site
243231008891	Transposase domain (DUF772); Region: DUF772; pfam05598
243231008892	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
243231008893	DDE superfamily endonuclease; Region: DDE_4; cl15789
243231008894	Caseinolytic protease (ClpP) is an ATP-dependent protease; Region: Clp_protease_like; cl15763
243231008895	active site
243231008896	Protein of unknown function (DUF2845); Region: DUF2845; pfam11006
243231008897	LysE type translocator; Region: LysE; cl00565
243231008898	Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600
243231008899	Helix-Turn-Helix DNA binding domain of putative Cfa-like transcription regulators; Region: HTH_Cfa-like_unk; cd04790
243231008900	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
243231008901	DNA binding residues [nucleotide binding]
243231008902	putative dimer interface [polypeptide binding]; other site
243231008903	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
243231008904	Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404
243231008905	Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404
243231008906	multidrug efflux protein; Reviewed; Region: PRK09579
243231008907	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076
243231008908	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
243231008909	cysteine desulfurase DndA; Region: DNA_S_dndA; TIGR03235
243231008910	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
243231008911	catalytic residue [active]
243231008912	DNA-binding transcriptional regulator CynR; Provisional; Region: PRK11242
243231008913	Helix-turn-helix domains; Region: HTH; cl00088
243231008914	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
243231008915	dimerization interface [polypeptide binding]; other site
243231008916	OsmC-like protein; Region: OsmC; cl00767
243231008917	PAS domain S-box; Region: sensory_box; TIGR00229
243231008918	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
243231008919	putative active site [active]
243231008920	heme pocket [chemical binding]; other site
243231008921	PAS domain S-box; Region: sensory_box; TIGR00229
243231008922	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459
243231008923	PAS fold; Region: PAS_4; pfam08448
243231008924	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
243231008925	putative active site [active]
243231008926	heme pocket [chemical binding]; other site
243231008927	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
243231008928	dimer interface [polypeptide binding]; other site
243231008929	phosphorylation site [posttranslational modification]
243231008930	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
243231008931	ATP binding site [chemical binding]; other site
243231008932	Mg2+ binding site [ion binding]; other site
243231008933	G-X-G motif; other site
243231008934	Putative heavy-metal-binding; Region: YbjQ_1; cl00426
243231008935	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
243231008936	S-adenosylmethionine binding site [chemical binding]; other site
243231008937	large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567
243231008938	Large-conductance mechanosensitive channel, MscL; Region: MscL; cl00860
243231008939	4Fe-4S binding domain; Region: Fer4; cl02805
243231008940	Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247
243231008941	Cysteine-rich domain; Region: CCG; pfam02754
243231008942	Cysteine-rich domain; Region: CCG; pfam02754
243231008943	Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025
243231008944	The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715
243231008945	Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766
243231008946	The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714
243231008947	Ligand binding site [chemical binding]; other site
243231008948	Electron transfer flavoprotein domain; Region: ETF; pfam01012
243231008949	putative acetyltransferase; Provisional; Region: PRK03624
243231008950	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
243231008951	Coenzyme A binding pocket [chemical binding]; other site
243231008952	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
243231008953	Radical SAM superfamily; Region: Radical_SAM; pfam04055
243231008954	FeS/SAM binding site; other site
243231008955	ADP-ribosylglycohydrolase; Region: ADP_ribosyl_GH; cl00614
243231008956	Cytochrome c554 and c-prime; Region: Cytochrome_C554; pfam13435
243231008957	Dinitrogenase reductase ADP-ribosyltransferase (DRAT); Region: DRAT; pfam07357
243231008958	NifB belongs to a family of iron-molybdenum cluster-binding proteins that includes NifX, and NifY, all of which are involved in the synthesis of an iron-molybdenum cofactor (FeMo-co) that binds the active site of the dinitrogenase enzyme as part of...; Region: NifB; cd00852
243231008959	ferredoxin III, nif-specific; Region: fdxN_nitrog; TIGR02936
243231008960	4Fe-4S binding domain; Region: Fer4; cl02805
243231008961	NifX belongs to a family of iron-molybdenum cluster-binding proteins that includes NifB,  and NifY, all of which are involved in the synthesis of an iron-molybdenum cofactor (FeMo-co) that binds the active site of the dinitrogenase enzyme.  The protein...; Region: NifX; cd00853
243231008962	bifunctional nitrogenase molybdenum-cofactor biosynthesis protein NifE/NifN; Provisional; Region: PRK14477
243231008963	Nitrogenase_NifE_I: a subgroup of the NifE subunit of the NifEN complex: NifE forms an alpha2beta2 tetramer with NifN.  NifE and NifN are structurally homologous to nitrogenase MoFe protein alpha and beta subunits respectively.  NifEN participates in the...; Region: Nitrogenase_NifE_I; cd01968
243231008964	Nitrogenase_nifN1: A subgroup of the NifN subunit of the NifEN complex: NifN forms an alpha2beta2 tetramer with NifE.  NifN and nifE are structurally homologous to nitrogenase MoFe protein beta and alpha subunits respectively.  NifEN participates in the...; Region: Nitrogenase_NifN_1; cd01966
243231008965	Peptidase M15; Region: Peptidase_M15_3; cl01194
243231008966	chaperone protein DnaJ; Region: DnaJ_bact; TIGR02349
243231008967	ferric uptake regulator; Provisional; Region: fur; PRK09462
243231008968	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153
243231008969	metal binding site 2 [ion binding]; metal-binding site
243231008970	putative DNA binding helix; other site
243231008971	metal binding site 1 [ion binding]; metal-binding site
243231008972	dimer interface [polypeptide binding]; other site
243231008973	structural Zn2+ binding site [ion binding]; other site
243231008974	Cytochrome c peroxidase [Inorganic ion transport and metabolism]; Region: MauG; COG1858
243231008975	NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976
243231008976	catalytic residues [active]
243231008977	Cytochrome c peroxidase [Inorganic ion transport and metabolism]; Region: MauG; COG1858
243231008978	Rubrerythrin [Energy production and conversion]; Region: COG1592
243231008979	Rubrerythrin, ferritin-like diiron-binding domain; Region: Rubrerythrin; cd01041
243231008980	binuclear metal center [ion binding]; other site
243231008981	Rubredoxin, Small Modular nonheme iron binding domain containing a [Fe(SCys)4] center, present in rubrerythrin and nigerythrin and detected either N- or C-terminal to such proteins as flavin reductase, NAD(P)H-nitrite reductase, and...; Region: rubredoxin_SM; cd00729
243231008982	iron binding site [ion binding]; other site
243231008983	PAS domain; Region: PAS_9; pfam13426
243231008984	PAS domain S-box; Region: sensory_box; TIGR00229
243231008985	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
243231008986	putative active site [active]
243231008987	heme pocket [chemical binding]; other site
243231008988	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
243231008989	PAS fold; Region: PAS_3; pfam08447
243231008990	putative active site [active]
243231008991	heme pocket [chemical binding]; other site
243231008992	PAS fold; Region: PAS_3; pfam08447
243231008993	Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain); Region: PAC; smart00086
243231008994	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
243231008995	dimer interface [polypeptide binding]; other site
243231008996	phosphorylation site [posttranslational modification]
243231008997	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
243231008998	ATP binding site [chemical binding]; other site
243231008999	Mg2+ binding site [ion binding]; other site
243231009000	G-X-G motif; other site
243231009001	Protein of unknown function (DUF3365); Region: DUF3365; pfam11845
243231009002	PAS fold; Region: PAS_3; pfam08447
243231009003	Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852
243231009004	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
243231009005	putative active site [active]
243231009006	heme pocket [chemical binding]; other site
243231009007	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
243231009008	dimer interface [polypeptide binding]; other site
243231009009	phosphorylation site [posttranslational modification]
243231009010	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
243231009011	ATP binding site [chemical binding]; other site
243231009012	Mg2+ binding site [ion binding]; other site
243231009013	G-X-G motif; other site
243231009014	Response regulator receiver domain; Region: Response_reg; pfam00072
243231009015	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
243231009016	active site
243231009017	phosphorylation site [posttranslational modification]
243231009018	intermolecular recognition site; other site
243231009019	dimerization interface [polypeptide binding]; other site
243231009020	putative DNA-binding transcriptional regulator; Provisional; Region: PRK10837
243231009021	Helix-turn-helix domains; Region: HTH; cl00088
243231009022	C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420
243231009023	putative dimerization interface [polypeptide binding]; other site
243231009024	Conserved hypothetical protein 698; Region: Cons_hypoth698; cl01075
243231009025	nitrogenase molybdenum-iron protein beta chain; Region: nifK; TIGR01286
243231009026	Domain of unknown function (DUF3364); Region: DUF3364; pfam11844
243231009027	Nitrogenase_MoFe_beta: Nitrogenase MoFe protein, beta subunit. The nitrogenase enzyme catalyzes the ATP-dependent reduction of dinitrogen to ammonia. The Molybdenum (Mo-) nitrogenase is the most widespread and best characterized of these systems; Region: Nitrogenase_MoFe_beta; cd01974
243231009028	MoFe protein beta/alpha subunit interactions; other site
243231009029	Beta subunit P cluster binding residues; other site
243231009030	MoFe protein beta subunit/Fe protein contacts; other site
243231009031	MoFe protein dimer/ dimer interactions; other site
243231009032	nitrogenase molybdenum-iron cofactor biosynthesis protein NifE; Region: nifE; TIGR01283
243231009033	Nitrogenase_MoFe_alpha_II: Nitrogenase MoFe protein, beta subunit. A group of proteins similar to the alpha subunit of the MoFe protein of the molybdenum (Mo-) nitrogenase. The nitrogenase enzyme catalyzes the ATP-dependent reduction of dinitrogen to...; Region: Nitrogenase_MoFe_alpha; cd01976
243231009034	MoFe protein alpha/beta subunit interactions; other site
243231009035	Alpha subunit P cluster binding residues; other site
243231009036	FeMoco binding residues [chemical binding]; other site
243231009037	MoFe protein alpha subunit/Fe protein contacts; other site
243231009038	MoFe protein dimer/ dimer interactions; other site
243231009039	NifH gene encodes component II (iron protein) of nitrogenase. Nitrogenase is responsible for the biological nitrogen fixation, i.e. reduction of molecular nitrogen to ammonia. NifH consists of two oxygen-sensitive metallosulfur proteins: the...; Region: NifH; cd02040
243231009040	nitrogenase iron protein; Region: nifH; TIGR01287
243231009041	Nucleotide-binding sites [chemical binding]; other site
243231009042	Walker A motif; other site
243231009043	Switch I region of nucleotide binding site; other site
243231009044	Fe4S4 binding sites [ion binding]; other site
243231009045	Switch II region of nucleotide binding site; other site
243231009046	Response regulator with putative antiterminator output domain [Signal transduction mechanisms]; Region: AmiR; COG3707
243231009047	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
243231009048	active site
243231009049	phosphorylation site [posttranslational modification]
243231009050	intermolecular recognition site; other site
243231009051	dimerization interface [polypeptide binding]; other site
243231009052	ANTAR domain; Region: ANTAR; cl04297
243231009053	Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404
243231009054	multidrug efflux system protein EmrA; Provisional; Region: PRK15136
243231009055	Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404
243231009056	ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668
243231009057	ABC-2 type transporter; Region: ABC2_membrane; cl11417
243231009058	ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668
243231009059	ABC-2 type transporter; Region: ABC2_membrane; cl11417
243231009060	Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cl00264
243231009061	dinuclear metal binding motif [ion binding]; other site
243231009062	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
243231009063	active site
243231009064	I-site; other site
243231009065	metal binding site [ion binding]; metal-binding site
243231009066	photolyase PhrII; Region: phr2; TIGR00591
243231009067	DNA photolyase; Region: DNA_photolyase; pfam00875
243231009068	FAD binding domain of DNA photolyase; Region: FAD_binding_7; pfam03441
243231009069	Ribosomal protein L17; Region: Ribosomal_L17; cl00356
243231009070	DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182
243231009071	N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928
243231009072	alphaNTD homodimer interface [polypeptide binding]; other site
243231009073	alphaNTD - beta interaction site [polypeptide binding]; other site
243231009074	alphaNTD - beta' interaction site [polypeptide binding]; other site
243231009075	Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; cl11613
243231009076	30S ribosomal protein S4; Validated; Region: rpsD; PRK05327
243231009077	Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163
243231009078	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
243231009079	RNA binding surface [nucleotide binding]; other site
243231009080	Ribosomal protein S11; Region: Ribosomal_S11; cl00332
243231009081	30S ribosomal protein S13; Validated; Region: rpsM; PRK05179
243231009082	Ribosomal protein S13/S18; Region: Ribosomal_S13; cl00331
243231009083	Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086
243231009084	active site
243231009085	adenylate kinase; Reviewed; Region: adk; PRK00279
243231009086	Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428
243231009087	AMP-binding site [chemical binding]; other site
243231009088	ATP-AMP (Ap5A)-binding site [chemical binding]; other site
243231009089	preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204
243231009090	SecY translocase; Region: SecY; pfam00344
243231009091	Ribosomal protein L18e/L15; Region: Ribosomal_L18e; cl12022
243231009092	Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658
243231009093	23S rRNA binding site [nucleotide binding]; other site
243231009094	30S ribosomal protein S5; Validated; Region: rpsE; PRK00550
243231009095	Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333
243231009096	Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719
243231009097	Ribosomal L18/L5e:  L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432
243231009098	5S rRNA interface [nucleotide binding]; other site
243231009099	L27 interface [polypeptide binding]; other site
243231009100	23S rRNA interface [nucleotide binding]; other site
243231009101	L5 interface [polypeptide binding]; other site
243231009102	50S ribosomal protein L6; Validated; Region: rplF; PRK05498
243231009103	Ribosomal protein L6; Region: Ribosomal_L6; pfam00347
243231009104	Ribosomal protein L6; Region: Ribosomal_L6; pfam00347
243231009105	Ribosomal protein S8; Region: Ribosomal_S8; cl00330
243231009106	Ribosomal protein S14p/S29e; Region: Ribosomal_S14; cl00355
243231009107	50S ribosomal protein L5; Validated; Region: rplE; PRK00010
243231009108	Ribosomal protein L5; Region: Ribosomal_L5; pfam00281
243231009109	ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673
243231009110	50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004
243231009111	KOW motif; Region: KOW; cl00354
243231009112	Ribosomal protein L14p/L23e; Region: Ribosomal_L14; cl00328
243231009113	Ribosomal protein S17; Region: Ribosomal_S17; cl00351
243231009114	Ribosomal L29 protein/HIP.  L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals.  L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427
243231009115	23S rRNA interface [nucleotide binding]; other site
243231009116	putative translocon interaction site; other site
243231009117	signal recognition particle (SRP54) interaction site; other site
243231009118	L23 interface [polypeptide binding]; other site
243231009119	trigger factor interaction site; other site
243231009120	Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433
243231009121	23S rRNA interface [nucleotide binding]; other site
243231009122	5S rRNA interface [nucleotide binding]; other site
243231009123	putative antibiotic binding site [chemical binding]; other site
243231009124	L25 interface [polypeptide binding]; other site
243231009125	L27 interface [polypeptide binding]; other site
243231009126	30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310
243231009127	K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3  is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel.  The KH...; Region: 30S_S3_KH; cd02412
243231009128	G-X-X-G motif; other site
243231009129	Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189
243231009130	Ribosomal protein L22/L17e.  L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit.  It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336
243231009131	putative translocon binding site; other site
243231009132	protein-rRNA interface [nucleotide binding]; other site
243231009133	Ribosomal protein S19; Region: Ribosomal_S19; cl00350
243231009134	50S ribosomal protein L2; Validated; Region: rplB; PRK09374
243231009135	Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181
243231009136	Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947
243231009137	Ribosomal protein L23; Region: Ribosomal_L23; cl00326
243231009138	Ribosomal protein L4/L1 family; Region: Ribosomal_L4; cl00325
243231009139	Ribosomal protein L3; Region: Ribosomal_L3; cl00324
243231009140	Ribosomal protein S10p/S20e; Region: Ribosomal_S10; cl00314
243231009141	elongation factor Tu; Reviewed; Region: PRK00049
243231009142	Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884
243231009143	G1 box; other site
243231009144	GEF interaction site [polypeptide binding]; other site
243231009145	GTP/Mg2+ binding site [chemical binding]; other site
243231009146	Switch I region; other site
243231009147	G2 box; other site
243231009148	G3 box; other site
243231009149	Switch II region; other site
243231009150	G4 box; other site
243231009151	G5 box; other site
243231009152	EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697
243231009153	Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707
243231009154	Antibiotic Binding Site [chemical binding]; other site
243231009155	elongation factor G; Reviewed; Region: PRK00007
243231009156	Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886
243231009157	G1 box; other site
243231009158	putative GEF interaction site [polypeptide binding]; other site
243231009159	GTP/Mg2+ binding site [chemical binding]; other site
243231009160	Switch I region; other site
243231009161	G2 box; other site
243231009162	G3 box; other site
243231009163	Switch II region; other site
243231009164	G4 box; other site
243231009165	G5 box; other site
243231009166	EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088
243231009167	EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434
243231009168	EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G.  Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713
243231009169	Ribosomal protein S7p/S5e; Region: Ribosomal_S7; cl00313
243231009170	S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368
243231009171	S17 interaction site [polypeptide binding]; other site
243231009172	S8 interaction site; other site
243231009173	16S rRNA interaction site [nucleotide binding]; other site
243231009174	streptomycin interaction site [chemical binding]; other site
243231009175	23S rRNA interaction site [nucleotide binding]; other site
243231009176	aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site
243231009177	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl04593
243231009178	DNA-directed RNA polymerase subunit beta'; Provisional; Region: PRK00566
243231009179	RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561
243231009180	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653
243231009181	RPB12 interaction site [polypeptide binding]; other site
243231009182	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl04593
243231009183	RPB11 interaction site [polypeptide binding]; other site
243231009184	RPB12 interaction site [polypeptide binding]; other site
243231009185	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653
243231009186	RPB3 interaction site [polypeptide binding]; other site
243231009187	RPB1 interaction site [polypeptide binding]; other site
243231009188	RPB11 interaction site [polypeptide binding]; other site
243231009189	RPB10 interaction site [polypeptide binding]; other site
243231009190	Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387
243231009191	L11 interface [polypeptide binding]; other site
243231009192	putative EF-Tu interaction site [polypeptide binding]; other site
243231009193	putative EF-G interaction site [polypeptide binding]; other site
243231009194	Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797
243231009195	23S rRNA interface [nucleotide binding]; other site
243231009196	Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site
243231009197	Ribosomal protein L1.  The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA.  In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403
243231009198	mRNA/rRNA interface [nucleotide binding]; other site
243231009199	50S ribosomal protein L11; Validated; Region: rplK; PRK00140
243231009200	Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349
243231009201	23S rRNA interface [nucleotide binding]; other site
243231009202	L7/L12 interface [polypeptide binding]; other site
243231009203	putative thiostrepton binding site; other site
243231009204	L25 interface [polypeptide binding]; other site
243231009205	transcription antitermination protein NusG; Validated; Region: nusG; PRK05609
243231009206	Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891
243231009207	putative homodimer interface [polypeptide binding]; other site
243231009208	KOW motif; Region: KOW; cl00354
243231009209	SecE/Sec61-gamma subunits of protein translocation complex; Region: SecE; cl00481
243231009210	Ribosomal protein L33; Region: Ribosomal_L33; cl00383
243231009211	elongation factor Tu; Reviewed; Region: PRK00049
243231009212	Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884
243231009213	G1 box; other site
243231009214	GEF interaction site [polypeptide binding]; other site
243231009215	GTP/Mg2+ binding site [chemical binding]; other site
243231009216	Switch I region; other site
243231009217	G2 box; other site
243231009218	G3 box; other site
243231009219	Switch II region; other site
243231009220	G4 box; other site
243231009221	G5 box; other site
243231009222	EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697
243231009223	Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707
243231009224	Antibiotic Binding Site [chemical binding]; other site
243231009225	The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714
243231009226	Ligand binding site [chemical binding]; other site
243231009227	Electron transfer flavoprotein domain; Region: ETF; pfam01012
243231009228	uncharacterized radical SAM protein YgiQ; Region: SAM_YgiQ; TIGR03904
243231009229	B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293
243231009230	Domain of unknown function (DUF3362); Region: DUF3362; pfam11842
243231009231	N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436
243231009232	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
243231009233	Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; cl15856
243231009234	Ribosomal protein S9/S16; Region: Ribosomal_S9; cl00334
243231009235	Ribosomal protein L13.  Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392
243231009236	23S rRNA interface [nucleotide binding]; other site
243231009237	L3 interface [polypeptide binding]; other site
243231009238	tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021
243231009239	Eukaryotic and bacterial pseudouridine synthases similar to E.  coli TruA; Region: PseudoU_synth_EcTruA; cd02570
243231009240	dimerization interface 3.5A [polypeptide binding]; other site
243231009241	active site
243231009242	aspartate-semialdehyde dehydrogenase; Reviewed; Region: PRK06598
243231009243	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
243231009244	Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; cl15856
243231009245	tartrate dehydrogenase; Provisional; Region: PRK08194
243231009246	Isocitrate/isopropylmalate dehydrogenase; Region: Iso_dh; cl00445
243231009247	Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504
243231009248	decaheme c-type cytochrome, OmcA/MtrC family; Region: decahem_SO1788; TIGR03507
243231009249	Heme-binding domain of the class III cytochrome C family and related proteins; Region: Cytochrom_C3; cl03439
243231009250	heme-binding residues [chemical binding]; other site
243231009251	decaheme c-type cytochrome, DmsE family; Region: decahem_SO; TIGR03508
243231009252	Geobacter CxxxxCH...CXXCH motif (GSu_C4xC__C2xCH); Region: GSu_C4xC__C2xCH; cl15457
243231009253	decaheme c-type cytochrome, DmsE family; Region: decahem_SO; TIGR03508
243231009254	NHL repeat; Region: NHL; pfam01436
243231009255	Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754
243231009256	Heme-binding domain of the class III cytochrome C family and related proteins; Region: Cytochrom_C3; cd08168
243231009257	heme-binding residues [chemical binding]; other site
243231009258	decaheme c-type cytochrome, DmsE family; Region: decahem_SO; TIGR03508
243231009259	Heme-binding domain of the class III cytochrome C family and related proteins; Region: Cytochrom_C3; cd08168
243231009260	heme-binding residues [chemical binding]; other site
243231009261	Heme-binding domain of the class III cytochrome C family and related proteins; Region: Cytochrom_C3; cd08168
243231009262	heme-binding residues [chemical binding]; other site
243231009263	decaheme c-type cytochrome, DmsE family; Region: decahem_SO; TIGR03508
243231009264	magnesium-protoporphyrin IX monomethyl ester anaerobic oxidative cyclase; Region: BchE; TIGR02026
243231009265	B12 binding domain_like associated with radical SAM domain. This domain shows similarity with B12 (adenosylcobamide) binding domains found in several enzymes, such as glutamate mutase, methionine synthase and methylmalonyl-CoA mutase, but it lacks the...; Region: radical_SAM_B12_BD; cd02068
243231009266	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
243231009267	FeS/SAM binding site; other site
243231009268	Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504
243231009269	ResB-like family; Region: ResB; pfam05140
243231009270	ResB protein required for cytochrome c biosynthesis [Posttranslational modification, protein turnover, chaperones]; Region: ResB; cl09125
243231009271	AMP-binding enzyme; Region: AMP-binding; cl15778
243231009272	Sel1 repeat; Region: Sel1; cl02723
243231009273	Sel1 repeat; Region: Sel1; cl02723
243231009274	Sel1 repeat; Region: Sel1; cl02723
243231009275	Sel1 repeat; Region: Sel1; cl02723
243231009276	Sel1 repeat; Region: Sel1; cl02723
243231009277	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
243231009278	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
243231009279	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
243231009280	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
243231009281	Ankyrin repeats (many copies); Region: Ank_5; pfam13857
243231009282	Geobacter CxxxxCH...CXXCH motif (GSu_C4xC__C2xCH); Region: GSu_C4xC__C2xCH; cl15457
243231009283	Geobacter CxxxxCH...CXXCH motif (GSu_C4xC__C2xCH); Region: GSu_C4xC__C2xCH; cl15457
243231009284	Geobacter CxxxxCH...CXXCH motif (GSu_C4xC__C2xCH); Region: GSu_C4xC__C2xCH; cl15457
243231009285	Geobacter CxxxxCH...CXXCH motif (GSu_C4xC__C2xCH); Region: GSu_C4xC__C2xCH; cl15457
243231009286	cytochrome c nitrite reductase, pentaheme subunit; Region: cyt_nit_nrfB; TIGR03146
243231009287	Geobacter CxxxxCH...CXXCH motif (GSu_C4xC__C2xCH); Region: GSu_C4xC__C2xCH; cl15457
243231009288	Geobacter CxxxxCH...CXXCH motif (GSu_C4xC__C2xCH); Region: GSu_C4xC__C2xCH; cl15457
243231009289	Geobacter CxxxxCH...CXXCH motif (GSu_C4xC__C2xCH); Region: GSu_C4xC__C2xCH; cl15457
243231009290	Geobacter CxxxxCH...CXXCH motif (GSu_C4xC__C2xCH); Region: GSu_C4xC__C2xCH; cl15457
243231009291	Sulphur transport; Region: Sulf_transp; cl01018
243231009292	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
243231009293	Tetratricopeptide repeat; Region: TPR_16; pfam13432
243231009294	TPR motif; other site
243231009295	ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; pfam12974
243231009296	NMT1-like family; Region: NMT1_2; cl15260
243231009297	Predicted Fe-S oxidoreductases [General function prediction only]; Region: COG0535
243231009298	Domain of unknown function (DUF4008); Region: DUF4008; cl14869
243231009299	Predicted Fe-S oxidoreductases [General function prediction only]; Region: COG0535
243231009300	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
243231009301	FeS/SAM binding site; other site
243231009302	Domain of unknown function (DUF4008); Region: DUF4008; cl14869
243231009303	Cupin domain; Region: Cupin_2; cl09118
243231009304	Predicted permeases [General function prediction only]; Region: COG0701
243231009305	Predicted permease; Region: DUF318; pfam03773
243231009306	ResB-like family; Region: ResB; pfam05140
243231009307	ResB-like family; Region: ResB; pfam05140
243231009308	NMT1-like family; Region: NMT1_2; cl15260
243231009309	NMT1-like family; Region: NMT1_2; cl15260
243231009310	Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383
243231009311	Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383
243231009312	Right handed beta helix region; Region: Beta_helix; pfam13229
243231009313	Periplasmic copper-binding protein (NosD); Region: NosD; pfam05048
243231009314	Seven times multi-haem cytochrome CxxCH; Region: Multi-haem_cyto; pfam13447
243231009315	Geobacter CxxxxCH...CXXCH motif (GSu_C4xC__C2xCH); Region: GSu_C4xC__C2xCH; cl15457
243231009316	Geobacter CxxxxCH...CXXCH motif (GSu_C4xC__C2xCH); Region: GSu_C4xC__C2xCH; cl15457
243231009317	decaheme c-type cytochrome, DmsE family; Region: decahem_SO; TIGR03508
243231009318	Doubled CXXCH motif (Paired_CXXCH_1); Region: Paired_CXXCH_1; cl09905
243231009319	haloacid dehalogenase-like hydrolase family protein; Region: PLN02919
243231009320	Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754
243231009321	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
243231009322	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
243231009323	active site
243231009324	phosphorylation site [posttranslational modification]
243231009325	intermolecular recognition site; other site
243231009326	dimerization interface [polypeptide binding]; other site
243231009327	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
243231009328	Walker A motif; other site
243231009329	ATP binding site [chemical binding]; other site
243231009330	Walker B motif; other site
243231009331	arginine finger; other site
243231009332	Helix-turn-helix domains; Region: HTH; cl00088
243231009333	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
243231009334	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
243231009335	dimerization interface [polypeptide binding]; other site
243231009336	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
243231009337	dimer interface [polypeptide binding]; other site
243231009338	phosphorylation site [posttranslational modification]
243231009339	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
243231009340	ATP binding site [chemical binding]; other site
243231009341	Mg2+ binding site [ion binding]; other site
243231009342	G-X-G motif; other site
243231009343	Transketolase, C-terminal subunit [Carbohydrate transport and metabolism]; Region: COG3958
243231009344	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
243231009345	PYR/PP interface [polypeptide binding]; other site
243231009346	dimer interface [polypeptide binding]; other site
243231009347	TPP binding site [chemical binding]; other site
243231009348	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
243231009349	Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012
243231009350	TPP-binding site [chemical binding]; other site
243231009351	dimer interface [polypeptide binding]; other site
243231009352	Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; cl14105
243231009353	Homocysteine S-methyltransferase; Region: S-methyl_trans; pfam02574
243231009354	Pterin binding enzymes. This family includes dihydropteroate synthase (DHPS) and cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH).  DHPS, a...; Region: Pterin_binding; cl00219
243231009355	substrate binding pocket [chemical binding]; other site
243231009356	dimer interface [polypeptide binding]; other site
243231009357	inhibitor binding site; inhibition site
243231009358	Predicted cobalamin binding protein [General function prediction only]; Region: COG5012
243231009359	B12 binding domain of corrinoid proteins. A family of small methanogenic corrinoid proteins that bind methyl-Co(III) 5-hydroxybenzimidazolylcobamide as a cofactor. They play a role on the methanogenesis from trimethylamine, dimethylamine or...; Region: corrinoid_protein_B12-BD; cd02070
243231009360	B12 binding site [chemical binding]; other site
243231009361	cobalt ligand [ion binding]; other site
243231009362	Sporulation and spore germination; Region: Germane; cl11253
243231009363	Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518
243231009364	Benzoyl-CoA reductase/2-hydroxyglutaryl-CoA dehydratase subunit, BcrC/BadD/HgdB [Amino acid transport and metabolism]; Region: HgdB; COG1775
243231009365	FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121
243231009366	Predicted metallopeptidase [General function prediction only]; Region: COG4900
243231009367	Hemerythrin (Hr) is a non-heme diiron oxygen transport protein found in four marine invertebrate phyla including priapulida, brachiopoda, sipunculida, and annelida, as well as in protozoa. Myohemerythrin (Mhr), a hemerythrin homolog, is found in the...; Region: Hemerythrin; cl15774
243231009368	octamerization interface [polypeptide binding]; other site
243231009369	diferric-oxygen binding site [ion binding]; other site
243231009370	Cytochrome c; Region: Cytochrom_C; cl11414
243231009371	Cytochrome c; Region: Cytochrom_C; cl11414
243231009372	Cytochrome b (N-terminus)/b6/petB:  Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859
243231009373	heme bH binding site [chemical binding]; other site
243231009374	intrachain domain interface; other site
243231009375	Qi binding site; other site
243231009376	heme bL binding site [chemical binding]; other site
243231009377	interchain domain interface [polypeptide binding]; other site
243231009378	Qo binding site; other site
243231009379	Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467
243231009380	iron-sulfur cluster [ion binding]; other site
243231009381	[2Fe-2S] cluster binding site [ion binding]; other site
243231009382	Cytochrome c552; Region: Cytochrom_C552; pfam02335
243231009383	Heme-binding domain of the class III cytochrome C family and related proteins; Region: Cytochrom_C3; cd08168
243231009384	heme-binding residues [chemical binding]; other site
243231009385	Heme-binding domain of the class III cytochrome C family and related proteins; Region: Cytochrom_C3; cd08168
243231009386	heme-binding residues [chemical binding]; other site
243231009387	Cytochrome c554 and c-prime; Region: Cytochrome_C554; pfam13435
243231009388	Phosphate-selective porin O and P; Region: Porin_O_P; cl01524
243231009389	Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897
243231009390	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125
243231009391	active site residue [active]
243231009392	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125
243231009393	active site residue [active]
243231009394	Transcriptional regulator [Transcription]; Region: LysR; COG0583
243231009395	Helix-turn-helix domains; Region: HTH; cl00088
243231009396	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
243231009397	dimerization interface [polypeptide binding]; other site
243231009398	Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729
243231009399	Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840
243231009400	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
243231009401	dimerization interface [polypeptide binding]; other site
243231009402	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
243231009403	dimer interface [polypeptide binding]; other site
243231009404	putative CheW interface [polypeptide binding]; other site
243231009405	Domain of unknown function (DUF4418); Region: DUF4418; pfam14387
243231009406	benzoyl-CoA reductase, bzd-type, N subunit; Region: benz_CoA_bzdN; cl11464
243231009407	2-hydroxyglutaryl-CoA dehydratase, D-component; Region: HGD-D; pfam06050
243231009408	FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121
243231009409	heavy metal response regulator; Region: cztR_silR_copR; TIGR01387
243231009410	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
243231009411	active site
243231009412	phosphorylation site [posttranslational modification]
243231009413	intermolecular recognition site; other site
243231009414	dimerization interface [polypeptide binding]; other site
243231009415	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
243231009416	DNA binding site [nucleotide binding]
243231009417	heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386
243231009418	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
243231009419	dimer interface [polypeptide binding]; other site
243231009420	phosphorylation site [posttranslational modification]
243231009421	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
243231009422	ATP binding site [chemical binding]; other site
243231009423	Mg2+ binding site [ion binding]; other site
243231009424	G-X-G motif; other site
243231009425	Sulfatase; Region: Sulfatase; cl10460
243231009426	PAP2_like_6 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which mainly contains bacterial proteins, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_6; cd03396
243231009427	active site
243231009428	ABC-type anion transport system, duplicated permease component [Inorganic ion transport and metabolism]; Region: COG4986
243231009429	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
243231009430	dimer interface [polypeptide binding]; other site
243231009431	conserved gate region; other site
243231009432	putative PBP binding loops; other site
243231009433	ABC-ATPase subunit interface; other site
243231009434	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427
243231009435	ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116
243231009436	NrtD and SsuB are the ATP-binding subunits of the bacterial ABC-type nitrate and sulfonate transport systems, respectively.  ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars; Region: ABC_NrtD_SsuB_transporters; cd03293
243231009437	Walker A/P-loop; other site
243231009438	ATP binding site [chemical binding]; other site
243231009439	Q-loop/lid; other site
243231009440	ABC transporter signature motif; other site
243231009441	Walker B; other site
243231009442	D-loop; other site
243231009443	H-loop/switch region; other site
243231009444	ABC nitrate/sulfonate/bicarbonate family transporter, ATPase subunit; Region: ABC_transp; cl15413
243231009445	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
243231009446	putative DNA binding site [nucleotide binding]; other site
243231009447	putative Zn2+ binding site [ion binding]; other site
243231009448	Low molecular weight phosphatase family; Region: LMWPc; cd00115
243231009449	Low molecular weight phosphotyrosine protein phosphatase; Region: LMWPc; pfam01451
243231009450	active site
243231009451	Arsenite efflux pump ACR3 and related permeases [Inorganic ion transport and metabolism]; Region: ACR3; COG0798
243231009452	Membrane transport protein; Region: Mem_trans; cl09117
243231009453	Predicted permeases [General function prediction only]; Region: COG0701
243231009454	Predicted permease; Region: DUF318; pfam03773
243231009455	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
243231009456	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
243231009457	catalytic residues [active]
243231009458	Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788
243231009459	Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053
243231009460	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
243231009461	molybdenum ABC transporter, ATP-binding protein; Region: modC_ABC; TIGR02142
243231009462	Walker A/P-loop; other site
243231009463	ATP binding site [chemical binding]; other site
243231009464	Q-loop/lid; other site
243231009465	ABC transporter signature motif; other site
243231009466	Walker B; other site
243231009467	D-loop; other site
243231009468	H-loop/switch region; other site
243231009469	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
243231009470	dimer interface [polypeptide binding]; other site
243231009471	conserved gate region; other site
243231009472	putative PBP binding loops; other site
243231009473	ABC-ATPase subunit interface; other site
243231009474	Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531
243231009475	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
243231009476	molybdenum transport protein ModD; Provisional; Region: PRK06096
243231009477	ModD; Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase) present in some modABC operons in bacteria, which are involved in molybdate transport. In general, QPRTases are part of the de novo synthesis pathway of NAD in both prokaryotes and...; Region: modD_like; cd01573
243231009478	dimerization interface [polypeptide binding]; other site
243231009479	active site
243231009480	Helix-turn-helix domains; Region: HTH; cl00088
243231009481	DNA-binding transcriptional regulator ModE; Provisional; Region: PRK10676
243231009482	TOBE domain; Region: TOBE_2; cl01440
243231009483	TOBE domain; Region: TOBE_2; cl01440
243231009484	Putative redox-active protein (C_GCAxxG_C_C); Region: C_GCAxxG_C_C; cl09920
243231009485	Uncharacterized family of ferritin-like proteins found in archaea and bacteria; Region: Ferritin_like_AB; cd01045
243231009486	diiron binding motif [ion binding]; other site
243231009487	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
243231009488	PAS domain; Region: PAS_9; pfam13426
243231009489	putative active site [active]
243231009490	heme pocket [chemical binding]; other site
243231009491	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
243231009492	metal binding site [ion binding]; metal-binding site
243231009493	active site
243231009494	I-site; other site
243231009495	Stress responsive A/B Barrel Domain; Region: Dabb; cl15807
243231009496	potential protein location (hypothetical protein) that overlaps protein (hypothetical protein)
243231009497	potential protein location (hypothetical protein) that overlaps protein (hypothetical protein)
243231009498	bifunctional homocysteine S-methyltransferase/5,10-methylenetetrahydrofolate reductase protein; Reviewed; Region: PRK08645
243231009499	Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; cl14105
243231009500	Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537
243231009501	FAD binding site [chemical binding]; other site
243231009502	putative manganese-dependent inorganic pyrophosphatase; Provisional; Region: PRK14869
243231009503	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with a DRTGG domain upstream. The function of the DRTGG domain, named after its conserved residues, is unknown. CBS is a small domain originally...; Region: CBS_pair_DRTGG_assoc2; cd04597
243231009504	DRTGG domain; Region: DRTGG; cl12147
243231009505	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354
243231009506	DHHA2 domain; Region: DHHA2; pfam02833
243231009507	Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586
243231009508	SNARE associated Golgi protein; Region: SNARE_assoc; cl00429
243231009509	Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956
243231009510	active site
243231009511	intersubunit interactions; other site
243231009512	catalytic residue [active]
243231009513	Ribosomal protein L24e/L24 is a ribosomal protein found in eukaryotes (L24) and in archaea (L24e, distinct from archaeal L24). L24e/L24 is located on the surface of the large subunit, adjacent to proteins L14 and L3, and near the translation factor...; Region: Ribosomal_L24e_L24; cl00909
243231009514	7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483
243231009515	catalytic center binding site [active]
243231009516	ATP binding site [chemical binding]; other site
243231009517	nickel responsive regulator; Provisional; Region: PRK04460
243231009518	Ribbon-helix-helix protein, copG family; Region: RHH_1; cl15783
243231009519	NikR C terminal nickel binding domain; Region: NikR_C; pfam08753
243231009520	Gram-negative bacterial tonB protein; Region: TonB; cl10048
243231009521	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
243231009522	N-terminal plug; other site
243231009523	TonB-dependent copper receptor; Region: TonB-copper; TIGR01778
243231009524	ligand-binding site [chemical binding]; other site
243231009525	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
243231009526	ABC-ATPase subunit  interface; other site
243231009527	dimer interface [polypeptide binding]; other site
243231009528	putative PBP binding regions; other site
243231009529	ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121
243231009530	ABC component of the metal-type transporters.  This family includes transporters involved in the uptake of various metallic cations such as iron, manganese, and zinc.  The ATPases of this group of transporters are very similar to members of...; Region: ABC_Metallic_Cations; cd03235
243231009531	Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+.  Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262
243231009532	Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297
243231009533	intersubunit interface [polypeptide binding]; other site
243231009534	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153
243231009535	metal binding site 2 [ion binding]; metal-binding site
243231009536	putative DNA binding helix; other site
243231009537	metal binding site 1 [ion binding]; metal-binding site
243231009538	dimer interface [polypeptide binding]; other site
243231009539	structural Zn2+ binding site [ion binding]; other site
243231009540	L-threonine-O-3-phosphate decarboxylase; Region: L_thr_O3P_dcar; TIGR01140
243231009541	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
243231009542	pyridoxal 5'-phosphate binding site [chemical binding]; other site
243231009543	homodimer interface [polypeptide binding]; other site
243231009544	catalytic residue [active]
243231009545	CobD/Cbib protein; Region: CobD_Cbib; cl00561
243231009546	Signal transduction histidine kinase, nitrate/nitrite-specific [Signal transduction mechanisms]; Region: NarQ; COG3850
243231009547	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
243231009548	dimerization interface [polypeptide binding]; other site
243231009549	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
243231009550	dimer interface [polypeptide binding]; other site
243231009551	phosphorylation site [posttranslational modification]
243231009552	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
243231009553	ATP binding site [chemical binding]; other site
243231009554	Mg2+ binding site [ion binding]; other site
243231009555	G-X-G motif; other site
243231009556	Precorrin-3B methylase [Coenzyme metabolism]; Region: CobJ; cl00304
243231009557	Tetrapyrrole (Corrin/Porphyrin) Methylases; Region: TP_methylase; pfam00590
243231009558	cobyric acid synthase; Provisional; Region: PRK00784
243231009559	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
243231009560	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
243231009561	Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750
243231009562	catalytic triad [active]
243231009563	cobalamin biosynthesis protein CbiG; Validated; Region: PRK05788
243231009564	Cobalamin synthesis G N-terminal; Region: CbiG_N; pfam11760
243231009565	Cobalamin biosynthesis central region; Region: CbiG_mid; pfam11761
243231009566	Cobalamin synthesis G C-terminus; Region: CbiG_C; cl12133
243231009567	Precorrin-3B methylase [Coenzyme metabolism]; Region: CobJ; cl00304
243231009568	Tetrapyrrole (Corrin/Porphyrin) Methylases; Region: TP_methylase; pfam00590
243231009569	Precorrin-3B methylase [Coenzyme metabolism]; Region: CobJ; cl00304
243231009570	Tetrapyrrole (Corrin/Porphyrin) Methylases; Region: TP_methylase; pfam00590
243231009571	Tetrapyrrole (Corrin/Porphyrin) Methylases; Region: TP_methylase; pfam00590
243231009572	Precorrin-3B methylase [Coenzyme metabolism]; Region: CobJ; cl00304
243231009573	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911
243231009574	cobalt-precorrin-6Y C(15)-methyltransferase; Validated; Region: PRK08287
243231009575	CbiD; Region: CbiD; cl00828
243231009576	Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381
243231009577	Precorrin isomerase [Coenzyme metabolism]; Region: CobH; cl00913
243231009578	Precorrin-8X methylmutase; Region: CbiC; pfam02570
243231009579	Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_N; cd03416
243231009580	putative active site [active]
243231009581	cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13639
243231009582	Domain I of the ABC component of a cobalt transport family found in bacteria, archaea, and eukaryota.  The transition metal cobalt is an essential component of many enzymes and must be transported into cells in appropriate amounts when needed.  This ABC...; Region: ABC_cobalt_CbiO_domain1; cd03225
243231009583	Walker A/P-loop; other site
243231009584	ATP binding site [chemical binding]; other site
243231009585	Q-loop/lid; other site
243231009586	ABC transporter signature motif; other site
243231009587	Walker B; other site
243231009588	D-loop; other site
243231009589	H-loop/switch region; other site
243231009590	Cobalt transport protein; Region: CbiQ; cl00463
243231009591	Cobalt uptake substrate-specific transmembrane region; Region: CbiM; cl00397
243231009592	ThiC family; Region: ThiC; cl08031
243231009593	cobyrinic acid a,c-diamide synthase; Validated; Region: PRK01077
243231009594	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
243231009595	Type 1 glutamine amidotransferase (GATase1) domain found in Cobyrinic Acid a,c-Diamide Synthase; Region: GATase1_CobB; cd03130
243231009596	catalytic triad [active]
243231009597	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
243231009598	catalytic core [active]
243231009599	Cobalamin-5-phosphate synthase; Region: CobS; cl00415
243231009600	Phosphoribosyltransferase; Region: DBI_PRT; pfam02277
243231009601	Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (DMB-PRT), also called CobT; Region: DMB-PRT_CobT; cd02439
243231009602	putative dimer interface [polypeptide binding]; other site
243231009603	active site pocket [active]
243231009604	putative cataytic base [active]
243231009605	Adenosylcobinamide kinase / adenosylcobinamide phosphate guanyltransferase (CobU). CobU is bifunctional cobalbumin biosynthesis enzymes which display adenosylcobinamide kinase and adenosylcobinamide phosphate guanyltransferase activity. This enzyme is a...; Region: CobU; cd00544
243231009606	homotrimer interface [polypeptide binding]; other site
243231009607	Walker A motif; other site
243231009608	GTP binding site [chemical binding]; other site
243231009609	Walker B motif; other site
243231009610	Predicted GTPase [General function prediction only]; Region: COG0218
243231009611	YihA (EngB) GTPase family; Region: YihA_EngB; cd01876
243231009612	G1 box; other site
243231009613	GTP/Mg2+ binding site [chemical binding]; other site
243231009614	Switch I region; other site
243231009615	G2 box; other site
243231009616	G3 box; other site
243231009617	Switch II region; other site
243231009618	G4 box; other site
243231009619	G5 box; other site
243231009620	HDOD domain; Region: HDOD; pfam08668
243231009621	CRISPR/Cas system-associated protein Cas3''; Region: Cas3''_I; cd09641
243231009622	FlaG protein; Region: FlaG; cl00591
243231009623	Immune inhibitor A peptidase M6; Region: Peptidase_M6; cl11525
243231009624	Early set domain associated with the catalytic domain of sugar utilizing enzymes at either the N or C terminus; Region: E_set; cl09101
243231009625	Early set domain associated with the catalytic domain of sugar utilizing enzymes at either the N or C terminus; Region: E_set; cl09101
243231009626	Early set domain associated with the catalytic domain of sugar utilizing enzymes at either the N or C terminus; Region: E_set; cl09101
243231009627	Early set domain associated with the catalytic domain of sugar utilizing enzymes at either the N or C terminus; Region: E_set; cl09101
243231009628	Early set domain associated with the catalytic domain of sugar utilizing enzymes at either the N or C terminus; Region: E_set; cl09101
243231009629	Early set domain associated with the catalytic domain of sugar utilizing enzymes at either the N or C terminus; Region: E_set; cl09101
243231009630	Early set domain associated with the catalytic domain of sugar utilizing enzymes at either the N or C terminus; Region: E_set; cl09101
243231009631	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911
243231009632	Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000
243231009633	pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_y; TIGR03182
243231009634	tetramer interface [polypeptide binding]; other site
243231009635	TPP-binding site [chemical binding]; other site
243231009636	heterodimer interface [polypeptide binding]; other site
243231009637	phosphorylation loop region [posttranslational modification]
243231009638	Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022
243231009639	Pyrimidine (PYR) binding domain of thiamine pyrophosphate (TPP)-dependent enzymes; Region: TPP_enzyme_PYR; cl11410
243231009640	PYR/PP interface [polypeptide binding]; other site
243231009641	dimer interface [polypeptide binding]; other site
243231009642	TPP binding site [chemical binding]; other site
243231009643	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
243231009644	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
243231009645	branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856
243231009646	E3 interaction surface; other site
243231009647	lipoyl attachment site [posttranslational modification]; other site
243231009648	sugar O-acyltransferase, sialic acid O-acetyltransferase NeuD family; Region: NeuD_NnaD; TIGR03570
243231009649	Putative Acyltransferase (AT), Left-handed parallel beta-Helix (LbH) domain; This group is composed of mostly uncharacterized proteins containing an N-terminal helical subdomain followed by a LbH domain. The alignment contains 6 turns, each containing...; Region: LbH_AT_putative; cd03360
243231009650	putative trimer interface [polypeptide binding]; other site
243231009651	putative CoA binding site [chemical binding]; other site
243231009652	DegT/DnrJ/EryC1/StrS aminotransferase family; Region: DegT_DnrJ_EryC1; pfam01041
243231009653	3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616
243231009654	inhibitor-cofactor binding pocket; inhibition site
243231009655	pyridoxal 5'-phosphate binding site [chemical binding]; other site
243231009656	catalytic residue [active]
243231009657	4-alpha-L-fucosyltransferase glycosyl transferase group 56; Region: Glyco_transf_56; cl07929
243231009658	2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1, 4-benzoquinol methylase [Coenzyme metabolism]; Region: UbiG; COG2227
243231009659	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911
243231009660	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911
243231009661	TPR repeat; Region: TPR_11; pfam13414
243231009662	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
243231009663	binding surface
243231009664	TPR motif; other site
243231009665	Methyltransferase domain; Region: Methyltransf_31; pfam13847
243231009666	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
243231009667	S-adenosylmethionine binding site [chemical binding]; other site
243231009668	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
243231009669	This family is most closely related to the GT1 family of glycosyltransferases. wcfI in Bacteroides fragilis has been shown to be involved in the capsular polysaccharide biosynthesis; Region: GT1_wcfI_like; cd03825
243231009670	Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186
243231009671	Probable Catalytic site; other site
243231009672	metal-binding site
243231009673	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
243231009674	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
243231009675	Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186
243231009676	Probable Catalytic site; other site
243231009677	metal-binding site
243231009678	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
243231009679	binding surface
243231009680	TPR repeat; Region: TPR_11; pfam13414
243231009681	TPR motif; other site
243231009682	Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking and secretion]; Region: TadD; COG5010
243231009683	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
243231009684	binding surface
243231009685	TPR motif; other site
243231009686	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
243231009687	binding surface
243231009688	TPR motif; other site
243231009689	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
243231009690	binding surface
243231009691	TPR motif; other site
243231009692	DUF based on E. rectale Gene description (DUF3880); Region: DUF3880; pfam12996
243231009693	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
243231009694	ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859
243231009695	Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789
243231009696	putative active site [active]
243231009697	Flagellar protein (FlbD); Region: FlbD; cl00683
243231009698	MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568
243231009699	Flagellar motor component [Cell motility and secretion]; Region: MotA; COG1291
243231009700	Flagellar motor protein [Cell motility and secretion]; Region: MotB; COG1360
243231009701	Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677
243231009702	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
243231009703	ligand binding site [chemical binding]; other site
243231009704	2-acyl-glycerophospho-ethanolamine acyltransferase; Validated; Region: PRK08633
243231009705	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
243231009706	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
243231009707	putative acyl-acceptor binding pocket; other site
243231009708	AMP-binding enzyme; Region: AMP-binding; cl15778
243231009709	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
243231009710	Transcriptional regulator containing PAS, AAA-type ATPase, and DNA-binding domains [Transcription / Signal transduction mechanisms]; Region: RocR; COG3829
243231009711	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
243231009712	DUF based on E. rectale Gene description (DUF3880); Region: DUF3880; pfam12996
243231009713	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
243231009714	PilZ domain; Region: PilZ; cl01260
243231009715	Oligoendopeptidase F [Amino acid transport and metabolism]; Region: COG1164
243231009716	Flagellar protein FliS; Region: FliS; cl00654
243231009717	Flagellar capping protein [Cell motility and secretion]; Region: FliD; COG1345
243231009718	Flagellar hook-associated protein 2 C-terminus; Region: FliD_N; pfam02465
243231009719	Flagellar hook-associated protein 2 C-terminus; Region: FliD_C; pfam07195
243231009720	flagellin; Provisional; Region: PRK12802
243231009721	Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669
243231009722	Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700
243231009723	FliW protein; Region: FliW; cl00740
243231009724	Global regulator protein family; Region: CsrA; cl00670
243231009725	flagellar hook-associated protein 3; Region: flagell_flgL; TIGR02550
243231009726	Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669
243231009727	Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700
243231009728	flagellar hook-associated protein FlgK; Region: flgK_ends; TIGR02492
243231009729	Flagella basal body rod protein; Region: Flg_bb_rod; cl16922
243231009730	Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; cl15855
243231009731	FlgN protein; Region: FlgN; cl09176
243231009732	Anti-sigma-28 factor, FlgM; Region: FlgM; cl01052
243231009733	flagellar rod assembly protein/muramidase FlgJ; Validated; Region: flgJ; PRK05684
243231009734	Rod binding protein; Region: Rod-binding; cl01626
243231009735	flagellar basal body P-ring protein; Provisional; Region: flgI; PRK05303
243231009736	flagellar basal body P-ring protein; Reviewed; Region: flgI; cl14622
243231009737	flagellar basal body L-ring protein; Reviewed; Region: flgH; PRK12698
243231009738	Flagellar L-ring protein; Region: FlgH; cl00905
243231009739	SAF-like; Region: SAF_2; pfam13144
243231009740	SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614
243231009741	Domains similar to fish antifreeze type III protein; Region: SAF; cl00555
243231009742	flagellar basal body rod protein FlgG; Provisional; Region: flgG; PRK12693
243231009743	Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; cl15855
243231009744	flagellar hook-basal body protein; Region: FlgEFG_subfam; TIGR03506
243231009745	Flagella basal body rod protein; Region: Flg_bb_rod; cl16922
243231009746	Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; cl15855
243231009747	RNA polymerase sigma factor, FliA/WhiG family; Region: FliA_WhiG; TIGR02479
243231009748	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
243231009749	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
243231009750	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
243231009751	DNA binding residues [nucleotide binding]
243231009752	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
243231009753	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
243231009754	Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455
243231009755	FleN is a member of the Fer4_NifH superfamily. It shares the common function as an ATPase, with the ATP-binding domain at the N-terminus. In Pseudomonas aeruginosa, FleN gene is involved in regulating the number of flagella and chemotactic motility by...; Region: FleN-like; cd02038
243231009756	flagellar biosynthesis regulator FlhF; Validated; Region: flhF; PRK05703
243231009757	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
243231009758	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
243231009759	flagellar biosynthesis protein FlhA; Validated; Region: flhA; cl07980
243231009760	FHIPEP family; Region: FHIPEP; pfam00771
243231009761	dihydropyrimidine dehydrogenase subunit A; Provisional; Region: PRK11749
243231009762	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
243231009763	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
243231009764	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
243231009765	ferredoxin-NADP(+) reductase subunit alpha; Reviewed; Region: PRK06222
243231009766	FAD/NAD binding domain in the electron transfer subunit of dihydroorotate dehydrogenase-like proteins. Dihydroorotate dehydrogenases (DHODs) catalyze the only redox reaction in pyrimidine de novo biosynthesis. They catalyze the oxidation of (S)...; Region: DHOD_e_trans_like1; cd06219
243231009767	FAD binding pocket [chemical binding]; other site
243231009768	FAD binding motif [chemical binding]; other site
243231009769	phosphate binding motif [ion binding]; other site
243231009770	beta-alpha-beta structure motif; other site
243231009771	NAD binding pocket [chemical binding]; other site
243231009772	Iron coordination center [ion binding]; other site
243231009773	Radical SAM superfamily; Region: Radical_SAM; pfam04055
243231009774	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
243231009775	FeS/SAM binding site; other site
243231009776	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
243231009777	Helix-turn-helix domains; Region: HTH; cl00088
243231009778	WHG domain; Region: WHG; pfam13305
243231009779	squalene-hopene cyclase; Region: hopene_cyclase; TIGR01507
243231009780	Squalene cyclase (SQCY) domain subgroup 1; found in class II terpene cyclases that have an alpha 6 - alpha 6 barrel fold. Squalene cyclase (SQCY)  and 2,3-oxidosqualene cyclase (OSQCY) are integral membrane proteins that catalyze a cationic cyclization...; Region: SQCY_1; cd02892
243231009781	Active site cavity [active]
243231009782	catalytic acid [active]
243231009783	radical SAM family uncharacterized protein; Region: rSAM_fuse_unch; TIGR03960
243231009784	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
243231009785	FeS/SAM binding site; other site
243231009786	cell division protein FtsZ; Validated; Region: PRK09330
243231009787	FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes.  FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201
243231009788	nucleotide binding site [chemical binding]; other site
243231009789	SulA interaction site; other site
243231009790	cell division protein FtsA; Region: ftsA; TIGR01174
243231009791	Cell division protein FtsA; Region: FtsA; cl11496
243231009792	Cell division protein FtsA; Region: FtsA; cl11496
243231009793	Cell division septal protein [Cell envelope biogenesis, outer membrane]; Region: FtsQ; COG1589
243231009794	POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478
243231009795	Cell division protein FtsQ; Region: FtsQ; pfam03799
243231009796	D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820
243231009797	D-alanine--D-alanine ligase; Reviewed; Region: ddl; PRK01372
243231009798	ATP-grasp domain; Region: ATP-grasp_4; cl03087
243231009799	UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13905
243231009800	FAD binding domain; Region: FAD_binding_4; pfam01565
243231009801	UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873
243231009802	UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421
243231009803	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
243231009804	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
243231009805	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
243231009806	undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726
243231009807	MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785
243231009808	active site
243231009809	homodimer interface [polypeptide binding]; other site
243231009810	Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511
243231009811	UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK14106
243231009812	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
243231009813	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
243231009814	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
243231009815	phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108
243231009816	Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852
243231009817	Mg++ binding site [ion binding]; other site
243231009818	putative catalytic motif [active]
243231009819	putative substrate binding site [chemical binding]; other site
243231009820	UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139
243231009821	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
243231009822	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
243231009823	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
243231009824	stage V sporulation protein D; Region: spoVD_pbp; TIGR02214
243231009825	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
243231009826	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009
243231009827	PASTA domain of PBP2x-like proteins, second repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_2; cd06575
243231009828	Septum formation initiator; Region: DivIC; cl11433
243231009829	Predicted S-adenosylmethionine-dependent methyltransferase involved in cell envelope biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG0275
243231009830	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911
243231009831	cell division protein MraZ; Reviewed; Region: PRK00326
243231009832	MraZ protein; Region: MraZ; pfam02381
243231009833	MraZ protein; Region: MraZ; pfam02381
243231009834	Putative zinc ribbon domain; Region: DUF164; pfam02591
243231009835	putative transposase OrfB; Reviewed; Region: PHA02517
243231009836	HTH-like domain; Region: HTH_21; pfam13276
243231009837	Integrase core domain; Region: rve; cl01316
243231009838	Integrase core domain; Region: rve_3; cl15866
243231009839	NIF3 (NGG1p interacting factor 3); Region: NIF3; cl15371
243231009840	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3323
243231009841	NIF3 (NGG1p interacting factor 3); Region: NIF3; cl15371
243231009842	Predicted N6-adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0116
243231009843	THUMP domain; Region: THUMP; cl12076
243231009844	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911
243231009845	SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2; cl00195
243231009846	This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002
243231009847	putative deacylase active site [active]
243231009848	Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979
243231009849	Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140
243231009850	RNA polymerase sigma factor RpoD, C-terminal domain; Region: RpoD_Cterm; TIGR02393
243231009851	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
243231009852	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
243231009853	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
243231009854	DNA binding residues [nucleotide binding]
243231009855	DNA primase; Validated; Region: dnaG; PRK05667
243231009856	CHC2 zinc finger; Region: zf-CHC2; cl15369
243231009857	DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275
243231009858	TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364
243231009859	active site
243231009860	metal binding site [ion binding]; metal-binding site
243231009861	interdomain interaction site; other site
243231009862	DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410
243231009863	Colicin V production protein; Region: Colicin_V; cl00567
243231009864	GatB domain; Region: GatB_Yqey; cl11497
243231009865	Ribosomal protein S21; Region: Ribosomal_S21; cl00529
243231009866	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534
243231009867	metal binding site [ion binding]; metal-binding site
243231009868	The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731
243231009869	Histidine biosynthesis protein; Region: His_biosynth; pfam00977
243231009870	substrate binding site [chemical binding]; other site
243231009871	glutamase interaction surface [polypeptide binding]; other site
243231009872	HisA.  Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732
243231009873	Histidine biosynthesis protein; Region: His_biosynth; pfam00977
243231009874	catalytic residues [active]
243231009875	imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13141
243231009876	Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748
243231009877	putative active site [active]
243231009878	oxyanion strand; other site
243231009879	catalytic triad [active]
243231009880	imidazoleglycerol-phosphate dehydratase; Validated; Region: hisB; PRK00951
243231009881	Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914
243231009882	putative active site pocket [active]
243231009883	4-fold oligomerization interface [polypeptide binding]; other site
243231009884	metal binding residues [ion binding]; metal-binding site
243231009885	3-fold/trimer interface [polypeptide binding]; other site
243231009886	histidinol-phosphate aminotransferase; Region: hisC; TIGR01141
243231009887	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
243231009888	pyridoxal 5'-phosphate binding site [chemical binding]; other site
243231009889	homodimer interface [polypeptide binding]; other site
243231009890	catalytic residue [active]
243231009891	Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572
243231009892	histidinol dehydrogenase; Region: hisD; TIGR00069
243231009893	NAD binding site [chemical binding]; other site
243231009894	dimerization interface [polypeptide binding]; other site
243231009895	product binding site; other site
243231009896	substrate binding site [chemical binding]; other site
243231009897	zinc binding site [ion binding]; other site
243231009898	catalytic residues [active]
243231009899	ATP phosphoribosyltransferase; Region: HisG; cl15266
243231009900	UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072
243231009901	UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555
243231009902	hinge; other site
243231009903	active site
243231009904	N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328
243231009905	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
243231009906	S-adenosylmethionine binding site [chemical binding]; other site
243231009907	peptide chain release factor 1; Validated; Region: prfA; PRK00591
243231009908	RF-1 domain; Region: RF-1; cl02875
243231009909	RF-1 domain; Region: RF-1; cl02875
243231009910	Protein of unknown function (DUF1385); Region: DUF1385; cl01595
243231009911	Thymidylate synthase complementing protein; Region: Thy1; cl03630
243231009912	Ribosomal protein L31; Region: Ribosomal_L31; cl00377
243231009913	transcription termination factor Rho; Provisional; Region: rho; PRK09376
243231009914	Rho termination factor, N-terminal domain; Region: Rho_N; cl06505
243231009915	Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459
243231009916	RNA binding site [nucleotide binding]; other site
243231009917	Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128
243231009918	multimer interface [polypeptide binding]; other site
243231009919	Walker A motif; other site
243231009920	ATP binding site [chemical binding]; other site
243231009921	Walker B motif; other site
243231009922	Transcriptional regulator [Transcription]; Region: IclR; COG1414
243231009923	Helix-turn-helix domains; Region: HTH; cl00088
243231009924	Bacterial transcriptional regulator; Region: IclR; pfam01614
243231009925	Domain of unknown function (DUF4117); Region: DUF4117; pfam13491
243231009926	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
243231009927	Ftsk gamma domain; Region: Ftsk_gamma; cl09645
243231009928	mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595
243231009929	Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446
243231009930	RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521
243231009931	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
243231009932	binding surface
243231009933	TPR motif; other site
243231009934	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
243231009935	putative acyl-acceptor binding pocket; other site
243231009936	SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496
243231009937	dimer interface [polypeptide binding]; other site
243231009938	ssDNA binding site [nucleotide binding]; other site
243231009939	tetramer (dimer of dimers) interface [polypeptide binding]; other site
243231009940	DNA-binding transcriptional regulator BaeR; Provisional; Region: PRK10710
243231009941	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
243231009942	active site
243231009943	phosphorylation site [posttranslational modification]
243231009944	intermolecular recognition site; other site
243231009945	dimerization interface [polypeptide binding]; other site
243231009946	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
243231009947	DNA binding site [nucleotide binding]
243231009948	signal transduction histidine-protein kinase BaeS; Provisional; Region: PRK10549
243231009949	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
243231009950	dimerization interface [polypeptide binding]; other site
243231009951	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
243231009952	dimer interface [polypeptide binding]; other site
243231009953	phosphorylation site [posttranslational modification]
243231009954	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
243231009955	ATP binding site [chemical binding]; other site
243231009956	Mg2+ binding site [ion binding]; other site
243231009957	G-X-G motif; other site
243231009958	CpxP component of the bacterial Cpx-two-component system and related proteins; Region: CpxP_like; cd09916
243231009959	dimer interface [polypeptide binding]; other site
243231009960	EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to...; Region: EFh; cl08302
243231009961	Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446
243231009962	Aldehyde ferredoxin oxidoreductase, N-terminal domain; Region: AFOR_N; cl08354
243231009963	Aldehyde ferredoxin oxidoreductase, domains 2 & 3; Region: AFOR_C; pfam01314
243231009964	Fe-S-cluster-containing hydrogenase components 2 [Energy production and conversion]; Region: HycB; COG1142
243231009965	Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064
243231009966	Cinnamyl alcohol dehydrogenases (CAD); Region: CAD1; cd05283
243231009967	putative NAD(P) binding site [chemical binding]; other site
243231009968	putative substrate binding site [chemical binding]; other site
243231009969	catalytic Zn binding site [ion binding]; other site
243231009970	structural Zn binding site [ion binding]; other site
243231009971	dimer interface [polypeptide binding]; other site
243231009972	Predicted oxidoreductases (related to aryl-alcohol dehydrogenases) [Energy production and conversion]; Region: Tas; COG0667
243231009973	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
243231009974	active site
243231009975	catalytic tetrad [active]
243231009976	AraC-type transcriptional regulator N-terminus; Region: AraC_N; pfam06719
243231009977	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
243231009978	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
243231009979	Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534
243231009980	MatE; Region: MatE; cl10513
243231009981	MatE; Region: MatE; cl10513
243231009982	Protein of unknown function (DUF1318); Region: DUF1318; cl01547
243231009983	TIGR02099 family protein; Region: TIGR02099
243231009984	AsmA-like C-terminal region; Region: AsmA_2; cl15864
243231009985	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
243231009986	IHF dimer interface [polypeptide binding]; other site
243231009987	IHF - DNA interface [nucleotide binding]; other site
243231009988	Membrane carboxypeptidase/penicillin-binding protein [Cell envelope biogenesis, outer membrane]; Region: MrcA; COG5009
243231009989	Transglycosylase; Region: Transgly; cl07896
243231009990	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009
243231009991	Protein of unknown function (DUF3187); Region: DUF3187; pfam11383
243231009992	Signal peptidase (SPase) II; Region: Peptidase_A8; cl00458
243231009993	lipoprotein signal peptidase; Provisional; Region: PRK14787
243231009994	isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743
243231009995	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
243231009996	active site
243231009997	HIGH motif; other site
243231009998	nucleotide binding site [chemical binding]; other site
243231009999	catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818
243231010000	active site
243231010001	KMSKS motif; other site
243231010002	Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960
243231010003	tRNA binding surface [nucleotide binding]; other site
243231010004	anticodon binding site; other site
243231010005	Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827
243231010006	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
243231010007	active site
243231010008	phosphorylation site [posttranslational modification]
243231010009	intermolecular recognition site; other site
243231010010	Signal transduction histidine kinase regulating citrate/malate metabolism [Signal transduction mechanisms]; Region: CitA; COG3290
243231010011	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
243231010012	dimer interface [polypeptide binding]; other site
243231010013	phosphorylation site [posttranslational modification]
243231010014	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
243231010015	ATP binding site [chemical binding]; other site
243231010016	Mg2+ binding site [ion binding]; other site
243231010017	G-X-G motif; other site
243231010018	Protein of unknown function, DUF399; Region: DUF399; cl01139
243231010019	Peptidase M1 family containing bacterial Aminopeptidase N; Region: M1_APN_5; cd09604
243231010020	Zn binding site [ion binding]; other site
243231010021	3-deoxy-7-phosphoheptulonate synthase; Reviewed; Region: PRK08673
243231010022	NeuB family; Region: NeuB; cl00496
243231010023	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; cl11587
243231010024	FKBP-type peptidyl-prolyl cis-trans isomerases 2 [Posttranslational modification, protein turnover, chaperones]; Region: SlpA; COG1047
243231010025	Predicted SAM-dependent methyltransferases [General function prediction only]; Region: COG1092
243231010026	Middle domain of the SAM-dependent methyltransferase RlmI and related proteins; Region: RlmI_M_like; cd11572
243231010027	putative RNA binding site [nucleotide binding]; other site
243231010028	MOSC domain; Region: MOSC; pfam03473
243231010029	molybdenum cofactor biosynthesis protein A; Reviewed; Region: moaA; PRK00164
243231010030	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
243231010031	FeS/SAM binding site; other site
243231010032	Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463
243231010033	Molybdenum is an essential trace element in the form of molybdenum cofactor (Moco) which is associated with the metabolism of nitrogen, carbon and sulfur by redox active enzymes. In E. coli, the synthesis of Moco involves genes from several loci: moa; Region: MobB; cd03116
243231010034	Walker A motif; other site
243231010035	GAF domain; Region: GAF_2; pfam13185
243231010036	GAF domain; Region: GAF; cl15785
243231010037	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
243231010038	dimer interface [polypeptide binding]; other site
243231010039	phosphorylation site [posttranslational modification]
243231010040	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
243231010041	ATP binding site [chemical binding]; other site
243231010042	Mg2+ binding site [ion binding]; other site
243231010043	G-X-G motif; other site
243231010044	HPP family; Region: HPP; pfam04982
243231010045	PAS domain S-box; Region: sensory_box; TIGR00229
243231010046	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
243231010047	putative active site [active]
243231010048	heme pocket [chemical binding]; other site
243231010049	Polyferredoxin [Energy production and conversion]; Region: NapH; COG0348
243231010050	4Fe-4S binding domain; Region: Fer4_5; pfam12801
243231010051	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
243231010052	Cytochrome c552; Region: Cytochrom_C552; pfam02335
243231010053	cytochrome c nitrate reductase, small subunit; Region: cytochr_NrfH; TIGR03153
243231010054	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
243231010055	dimer interface [polypeptide binding]; other site
243231010056	putative CheW interface [polypeptide binding]; other site
243231010057	3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427
243231010058	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
243231010059	Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031
243231010060	CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561
243231010061	dimer interface [polypeptide binding]; other site
243231010062	pyridoxal 5'-phosphate binding site [chemical binding]; other site
243231010063	catalytic residue [active]
243231010064	Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426
243231010065	putative active site [active]
243231010066	putative CoA binding site [chemical binding]; other site
243231010067	nudix motif; other site
243231010068	metal binding site [ion binding]; metal-binding site
243231010069	tRNA pseudouridine isomerase C; Region: PseudoU_synth_TruC; cd02563
243231010070	probable active site [active]
243231010071	Peptide methionine sulfoxide reductase; Region: PMSR; cl00366
243231010072	Low-specificity threonine aldolase (TA). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I).  TA catalyzes the conversion of L-threonine or L-allo-threonine to glycine and acetaldehyde in a...; Region: TA_like; cd06502
243231010073	Beta-eliminating lyase; Region: Beta_elim_lyase; pfam01212
243231010074	tetramer interface [polypeptide binding]; other site
243231010075	pyridoxal 5'-phosphate binding site [chemical binding]; other site
243231010076	catalytic residue [active]
243231010077	NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976
243231010078	Uncharacterized protein conserved in bacteria (DUF2077); Region: DUF2077; cl01370
243231010079	ImcF-related N-terminal domain; Region: ImcF-related_N; pfam14331
243231010080	Uncharacterized protein conserved in bacteria (DUF2094); Region: DUF2094; cl01611
243231010081	Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and    vesicular transport]; Region: COG3515
243231010082	ImpA-related N-terminal; Region: ImpA-rel_N; pfam06812
243231010083	type VI secretion-associated protein, VC_A0119 family; Region: VI_chp_7; TIGR03362
243231010084	3-oxoacyl-(acyl carrier protein) synthase; Validated; Region: PRK06147
243231010085	Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938
243231010086	PAAR motif; Region: PAAR_motif; cl15808
243231010087	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
243231010088	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
243231010089	Protein of unknown function (DUF770); Region: DUF770; cl01402
243231010090	Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and    vesicular transport]; Region: COG3517; cl05484
243231010091	Protein of unknown function (DUF877); Region: DUF877; pfam05943
243231010092	Protein of unknown function (DUF796); Region: DUF796; cl01226
243231010093	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
243231010094	type VI secretion system Vgr family protein; Region: VI_Rhs_Vgr; TIGR03361
243231010095	Phage late control gene D protein (GPD); Region: Phage_GPD; cl15796
243231010096	Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717
243231010097	Gp5 C-terminal repeat (3 copies); Region: Gp5_C; pfam06715
243231010098	baseplate hub subunit and tail lysozyme; Provisional; Region: 5; PHA02596
243231010099	Gp5 C-terminal repeat (3 copies); Region: Gp5_C; pfam06715
243231010100	conserved hypothetical protein; Region: TIGR02270
243231010101	3-oxoacyl-(acyl carrier protein) synthase; Validated; Region: PRK06147
243231010102	Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938
243231010103	active site
243231010104	Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938
243231010105	active site
243231010106	PAAR motif; Region: PAAR_motif; cl15808
243231010107	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
243231010108	Uncharacterized protein conserved in bacteria (DUF2169); Region: DUF2169; cl02212
243231010109	4Fe-4S single cluster domain; Region: Fer4_15; pfam13459
243231010110	Protein of unknown function (DUF1271); Region: DUF1271; cl01443
243231010111	Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730
243231010112	Rubredoxin; Region: Rubredoxin; pfam00301
243231010113	iron binding site [ion binding]; other site
243231010114	Transcription elongation factor Elf1 like; Region: Elf1; cl02038
243231010115	mttA/Hcf106 family; Region: MttA_Hcf106; cl00788
243231010116	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
243231010117	binding surface
243231010118	TPR motif; other site
243231010119	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
243231010120	binding surface
243231010121	TPR motif; other site
243231010122	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
243231010123	binding surface
243231010124	TPR motif; other site
243231010125	TPR repeat; Region: TPR_11; pfam13414
243231010126	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
243231010127	binding surface
243231010128	TPR motif; other site
243231010129	TPR repeat; Region: TPR_11; pfam13414
243231010130	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
243231010131	binding surface
243231010132	TPR motif; other site
243231010133	TPR repeat; Region: TPR_11; pfam13414
243231010134	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
243231010135	binding surface
243231010136	TPR motif; other site
243231010137	Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain  (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464
243231010138	putative dimer interface [polypeptide binding]; other site
243231010139	ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466
243231010140	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
243231010141	Walker A motif; other site
243231010142	ATP binding site [chemical binding]; other site
243231010143	Walker B motif; other site
243231010144	arginine finger; other site
243231010145	Subunit ChlI of Mg-chelatase; Region: ChlI; cl12214
243231010146	thiamine monophosphate kinase; Provisional; Region: PRK05731
243231010147	ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194
243231010148	ATP binding site [chemical binding]; other site
243231010149	dimerization interface [polypeptide binding]; other site
243231010150	Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352
243231010151	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911
243231010152	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054
243231010153	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
243231010154	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
243231010155	dimer interface [polypeptide binding]; other site
243231010156	putative CheW interface [polypeptide binding]; other site
243231010157	CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256
243231010158	Response regulator receiver domain; Region: Response_reg; pfam00072
243231010159	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
243231010160	active site
243231010161	phosphorylation site [posttranslational modification]
243231010162	intermolecular recognition site; other site
243231010163	dimerization interface [polypeptide binding]; other site
243231010164	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088
243231010165	putative binding surface; other site
243231010166	active site
243231010167	Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895
243231010168	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
243231010169	ATP binding site [chemical binding]; other site
243231010170	Mg2+ binding site [ion binding]; other site
243231010171	G-X-G motif; other site
243231010172	CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256
243231010173	Chemotaxis protein CheC, inhibitor of MCP methylation [Cell motility and secretion / Signal transduction mechanisms]; Region: CheC; COG1776
243231010174	Chemotaxis phosphatase CheX; Region: CheX; cl15816
243231010175	Chemotaxis phosphatase CheX; Region: CheX; cl15816
243231010176	CheD chemotactic sensory transduction; Region: CheD; cl00810
243231010177	Outer membrane lipoprotein carrier protein LolA; Region: LolA; cl01065
243231010178	lipoprotein chaperone; Reviewed; Region: lolA; PRK00031
243231010179	Outer membrane lipoprotein carrier protein LolA; Region: LolA; cl01065
243231010180	Protein of unknown function (DUF520); Region: DUF520; cl00723
243231010181	ribosomal protein S12 methylthiotransferase RimO; Region: TIGR01125
243231010182	Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919
243231010183	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
243231010184	FeS/SAM binding site; other site
243231010185	Prokaryotic dksA/traR C4-type zinc finger; Region: zf-dskA_traR; cl00755
243231010186	Sulfatase; Region: Sulfatase; cl10460
243231010187	Phosphoglyceromutase [Carbohydrate transport and metabolism]; Region: GpmI; COG0696
243231010188	Uncharacterized conserved protein [Function unknown]; Region: COG1576; cl00679
243231010189	Predicted SPOUT methyltransferase; Region: SPOUT_MTase; pfam02590
243231010190	Oligomerisation domain; Region: Oligomerisation; cl00519
243231010191	nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071
243231010192	Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165
243231010193	active site
243231010194	(T/H)XGH motif; other site
243231010195	Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079
243231010196	gamma-glutamyl phosphate reductase; Region: proA; TIGR00407
243231010197	putative catalytic cysteine [active]
243231010198	gamma-glutamyl kinase; Provisional; Region: PRK05429
243231010199	AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242
243231010200	nucleotide binding site [chemical binding]; other site
243231010201	homotetrameric interface [polypeptide binding]; other site
243231010202	putative phosphate binding site [ion binding]; other site
243231010203	putative allosteric binding site; other site
243231010204	PUA domain; Region: PUA; cl00607
243231010205	GTPase CgtA; Reviewed; Region: obgE; PRK12299
243231010206	GTP1/OBG; Region: GTP1_OBG; pfam01018
243231010207	Obg GTPase; Region: Obg; cd01898
243231010208	G1 box; other site
243231010209	GTP/Mg2+ binding site [chemical binding]; other site
243231010210	Switch I region; other site
243231010211	G2 box; other site
243231010212	G3 box; other site
243231010213	Switch II region; other site
243231010214	G4 box; other site
243231010215	G5 box; other site
243231010216	sensory histidine kinase AtoS; Provisional; Region: PRK11360
243231010217	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075
243231010218	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
243231010219	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
243231010220	active site
243231010221	phosphorylation site [posttranslational modification]
243231010222	intermolecular recognition site; other site
243231010223	dimerization interface [polypeptide binding]; other site
243231010224	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
243231010225	Walker A motif; other site
243231010226	ATP binding site [chemical binding]; other site
243231010227	Walker B motif; other site
243231010228	arginine finger; other site
243231010229	Helix-turn-helix domains; Region: HTH; cl00088
243231010230	Doubled CXXCH motif (Paired_CXXCH_1); Region: Paired_CXXCH_1; cl09905
243231010231	decaheme c-type cytochrome, DmsE family; Region: decahem_SO; TIGR03508
243231010232	Doubled CXXCH motif (Paired_CXXCH_1); Region: Paired_CXXCH_1; cl09905
243231010233	Doubled CXXCH motif (Paired_CXXCH_1); Region: Paired_CXXCH_1; cl09905
243231010234	Doubled CXXCH motif (Paired_CXXCH_1); Region: Paired_CXXCH_1; cl09905
243231010235	Doubled CXXCH motif (Paired_CXXCH_1); Region: Paired_CXXCH_1; cl09905
243231010236	Doubled CXXCH motif (Paired_CXXCH_1); Region: Paired_CXXCH_1; cl09905
243231010237	Peptidase S8 family domain in Kp43 proteases; Region: Peptidases_S8_Kp43_protease; cd04842
243231010238	active site
243231010239	catalytic triad [active]
243231010240	Uncharacterized conserved protein [Function unknown]; Region: COG1572
243231010241	Fibronectin type III-like domain; Region: Fn3-like; cl15273
243231010242	Fibronectin type III-like domain; Region: Fn3-like; cl15273
243231010243	Fibronectin type III-like domain; Region: Fn3-like; cl15273
243231010244	Fibronectin type III-like domain; Region: Fn3-like; cl15273
243231010245	Fibronectin type III-like domain; Region: Fn3-like; cl15273
243231010246	Fibronectin type III-like domain; Region: Fn3-like; cl15273
243231010247	Fibronectin type III-like domain; Region: Fn3-like; cl15273
243231010248	Doubled CXXCH motif (Paired_CXXCH_1); Region: Paired_CXXCH_1; cl09905
243231010249	Uncharacterized conserved protein [Function unknown]; Region: COG3391
243231010250	NHL repeat; Region: NHL; pfam01436
243231010251	Doubled CXXCH motif (Paired_CXXCH_1); Region: Paired_CXXCH_1; cl09905
243231010252	Doubled CXXCH motif (Paired_CXXCH_1); Region: Paired_CXXCH_1; cl09905
243231010253	Uncharacterized conserved protein [Function unknown]; Region: COG3391
243231010254	NHL repeat; Region: NHL; pfam01436
243231010255	NHL repeat; Region: NHL; pfam01436
243231010256	NHL repeat; Region: NHL; pfam01436
243231010257	decaheme c-type cytochrome, DmsE family; Region: decahem_SO; TIGR03508
243231010258	Cytochrome c554 and c-prime; Region: Cytochrome_C554; pfam13435
243231010259	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
243231010260	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
243231010261	active site
243231010262	phosphorylation site [posttranslational modification]
243231010263	intermolecular recognition site; other site
243231010264	dimerization interface [polypeptide binding]; other site
243231010265	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
243231010266	DNA binding residues [nucleotide binding]
243231010267	dimerization interface [polypeptide binding]; other site
243231010268	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459
243231010269	PAS domain; Region: PAS_9; pfam13426
243231010270	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920
243231010271	Histidine kinase; Region: HisKA_3; pfam07730
243231010272	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
243231010273	ATP binding site [chemical binding]; other site
243231010274	Mg2+ binding site [ion binding]; other site
243231010275	G-X-G motif; other site
243231010276	Early set domain associated with the catalytic domain of sugar utilizing enzymes at either the N or C terminus; Region: E_set; cl09101
243231010277	Ribosomal L27 protein; Region: Ribosomal_L27; cl00359
243231010278	Ribosomal prokaryotic L21 protein; Region: Ribosomal_L21p; cl00382
243231010279	Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938
243231010280	iron-sulfur cluster [ion binding]; other site
243231010281	[2Fe-2S] cluster binding site [ion binding]; other site
243231010282	ribonuclease G; Provisional; Region: PRK11712
243231010283	S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453
243231010284	homodimer interface [polypeptide binding]; other site
243231010285	oligonucleotide binding site [chemical binding]; other site
243231010286	radical SAM family uncharacterized protein; Region: rSAM_fuse_unch; TIGR03960
243231010287	B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293
243231010288	B12 binding site [chemical binding]; other site
243231010289	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
243231010290	FeS/SAM binding site; other site
243231010291	radical SAM-linked protein; Region: sam_1_link_chp; TIGR03936
243231010292	Uncharacterized protein conserved in bacteria (DUF2344); Region: DUF2344; cl02090
243231010293	potential protein location (hypothetical protein) that overlaps protein (hypothetical protein)
243231010294	potential protein location (hypothetical protein) that overlaps protein (hypothetical protein)
243231010295	putative exosortase-associated protein, TIGR04073 family; Region: exo_TIGR04073
243231010296	putative exosortase-associated protein, TIGR04073 family; Region: exo_TIGR04073
243231010297	Uncharacterized bacterial subgroup of the DEDDy 3'-5' exonuclease domain of family-B DNA polymerases; Region: DNA_polB_like2_exo; cd05785
243231010298	active site
243231010299	catalytic site [active]
243231010300	substrate binding site [chemical binding]; other site
243231010301	DNA polymerase type-II B subfamily catalytic domain. Bacteria contain five DNA polymerases (I, II, III, IV and V). DNA polymerase II (Pol II) is a prototype for the B-family of polymerases. The role of Pol II in a variety of cellular activities, such as...; Region: POLBc_Pol_II_B; cd05538
243231010302	active site
243231010303	metal-binding site
243231010304	Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450
243231010305	Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015
243231010306	dimer interface [polypeptide binding]; other site
243231010307	decamer (pentamer of dimers) interface [polypeptide binding]; other site
243231010308	catalytic triad [active]
243231010309	peroxidatic and resolving cysteines [active]
243231010310	4Fe-4S binding domain; Region: Fer4; cl02805
243231010311	hypothetical protein; Provisional; Region: PRK13795
243231010312	Nitrous oxide-stimulated promoter; Region: YgbA_NO; cl08119
243231010313	poly(A) polymerase; Region: pcnB; TIGR01942
243231010314	Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398
243231010315	active site
243231010316	NTP binding site [chemical binding]; other site
243231010317	metal binding triad [ion binding]; metal-binding site
243231010318	Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627
243231010319	Polymerase A arginine-rich C-terminus; Region: PolyA_pol_arg_C; pfam12626
243231010320	Protein of unknown function (DUF523); Region: DUF523; cl00733
243231010321	Protein of unknown function (DUF1722); Region: DUF1722; cl01284
243231010322	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
243231010323	GAF domain; Region: GAF; cl15785
243231010324	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
243231010325	dimer interface [polypeptide binding]; other site
243231010326	phosphorylation site [posttranslational modification]
243231010327	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
243231010328	ATP binding site [chemical binding]; other site
243231010329	Mg2+ binding site [ion binding]; other site
243231010330	G-X-G motif; other site
243231010331	Response regulator receiver domain; Region: Response_reg; pfam00072
243231010332	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
243231010333	active site
243231010334	phosphorylation site [posttranslational modification]
243231010335	intermolecular recognition site; other site
243231010336	dimerization interface [polypeptide binding]; other site
243231010337	Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208
243231010338	NTP_transferases catalyze the transfer of nucleotides onto phosphosugars; Region: NTP_transferase; cd04181
243231010339	active site
243231010340	Substrate binding site; other site
243231010341	Mg++ binding site; other site
243231010342	Left-handed parallel beta-Helix (LbH) domain of a group of proteins with similarity to glucose-1-phosphate adenylyltransferase: Included in this family are glucose-1-phosphate adenylyltransferase, mannose-1-phosphate guanylyltransferase, and the...; Region: LbH_G1P_AT_C_like; cd03356
243231010343	GTP-mannose-1-phosphate guanyltransferase (MPG1 transferase), also known as GDP-mannose pyrophosphorylase, is a bifunctional enzyme with both phosphomannose isomerase (PMI) activity and GDP-mannose phosphorylase (GMP) activity.  The protein contains an...; Region: MPG1_transferase; cd05805
243231010344	phosphoglucosamine mutase; Region: Arch_GlmM; TIGR03990
243231010345	Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692
243231010346	Glycosyl hydrolase family 57; Region: Glyco_hydro_57; pfam03065
243231010347	N-terminal catalytic domain of thermoactive amylopullulanases; glycoside hydrolase family 57 (GH57); Region: GH57N_APU; cd10796
243231010348	putative active site [active]
243231010349	catalytic site [active]
243231010350	ADP-glucose phosphorylase; Region: PLN02643
243231010351	Galactose-1-phosphate uridyl transferase (GalT): This enzyme plays a key role in galactose metabolism by catalysing the transfer of a uridine 5'-phosphoryl group from UDP-galactose 1-phosphate. The structure of E.coli GalT reveals that the enzyme...; Region: GalT; cd00608
243231010352	dimer interface [polypeptide binding]; other site
243231010353	active site
243231010354	glycogen synthase; Provisional; Region: glgA; PRK00654
243231010355	This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791
243231010356	ADP-binding pocket [chemical binding]; other site
243231010357	homodimer interface [polypeptide binding]; other site
243231010358	Protein of unknown function (DUF4199); Region: DUF4199; pfam13858
243231010359	cytochrome c nitrate reductase, small subunit; Region: cytochr_NrfH; TIGR03153
243231010360	Serine-pyruvate aminotransferase/archaeal aspartate aminotransferase [Amino acid transport and metabolism]; Region: COG0075
243231010361	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
243231010362	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
243231010363	catalytic residue [active]
243231010364	Response regulator receiver domain; Region: Response_reg; pfam00072
243231010365	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
243231010366	active site
243231010367	phosphorylation site [posttranslational modification]
243231010368	intermolecular recognition site; other site
243231010369	dimerization interface [polypeptide binding]; other site
243231010370	excinuclease ABC subunit B; Provisional; Region: PRK05298
243231010371	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
243231010372	ATP binding site [chemical binding]; other site
243231010373	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
243231010374	nucleotide binding region [chemical binding]; other site
243231010375	ATP-binding site [chemical binding]; other site
243231010376	Ultra-violet resistance protein B; Region: UvrB; pfam12344
243231010377	UvrB/uvrC motif; Region: UVR; pfam02151
243231010378	Response regulator receiver domain; Region: Response_reg; pfam00072
243231010379	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
243231010380	active site
243231010381	phosphorylation site [posttranslational modification]
243231010382	intermolecular recognition site; other site
243231010383	dimerization interface [polypeptide binding]; other site
243231010384	PilZ domain; Region: PilZ; cl01260
243231010385	Permeases of the major facilitator superfamily [General function prediction only]; Region: COG2270
243231010386	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
243231010387	putative substrate translocation pore; other site
243231010388	NAD(P)H-nitrite reductase [Energy production and conversion]; Region: NirB; COG1251
243231010389	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
243231010390	PHP family phosphoesterase with a Zn ribbon [General function prediction only]; Region: COG1379
243231010391	Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210
243231010392	Family description; Region: UvrD_C_2; cl15862
243231010393	Virus attachment protein p12 family; Region: P12; pfam12669
243231010394	Fe2+ transport system protein B [Inorganic ion transport and metabolism]; Region: FeoB; COG0370
243231010395	Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879
243231010396	G1 box; other site
243231010397	GTP/Mg2+ binding site [chemical binding]; other site
243231010398	Switch I region; other site
243231010399	G2 box; other site
243231010400	G3 box; other site
243231010401	Switch II region; other site
243231010402	G4 box; other site
243231010403	G5 box; other site
243231010404	Nucleoside recognition; Region: Gate; cl00486
243231010405	Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664
243231010406	Nucleoside recognition; Region: Gate; cl00486
243231010407	FeoA domain; Region: FeoA; cl00838
243231010408	Carbohydrate-selective porin, OprB family; Region: OprB; pfam04966
243231010409	Carbohydrate-selective porin [Cell envelope biogenesis, outer membrane]; Region: OprB; COG3659
243231010410	Protein of unknown function (DUF3793); Region: DUF3793; pfam12672
243231010411	Uncharacterized protein conserved in bacteria (DUF2325); Region: DUF2325; cl01811
243231010412	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
243231010413	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
243231010414	tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795
243231010415	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
243231010416	Chlamydia cysteine-rich outer membrane protein 6; Region: Chlam_OMP6; pfam03504
243231010417	excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558
243231010418	Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434
243231010419	GIY-YIG motif/motif A; other site
243231010420	active site
243231010421	catalytic site [active]
243231010422	putative DNA binding site [nucleotide binding]; other site
243231010423	metal binding site [ion binding]; metal-binding site
243231010424	UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459
243231010425	H3TH domains of structure-specific 5' nucleases (or flap endonuclease-1-like) involved in DNA replication, repair, and recombination; Region: H3TH_StructSpec-5'-nucleases; cl14815
243231010426	Uncharacterized protein SCO1/SenC/PrrC, involved in biogenesis of respiratory and photosynthetic systems [General function prediction only]; Region: COG1999
243231010427	TlpA-like family; composed of  TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966
243231010428	catalytic residues [active]
243231010429	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
243231010430	catalytic residues [active]
243231010431	Siroheme synthase (precorrin-2 oxidase/ferrochelatase domain) [Coenzyme metabolism]; Region: CysG; COG1648
243231010432	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
243231010433	Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504
243231010434	glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045
243231010435	NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213
243231010436	tRNA; other site
243231010437	putative tRNA binding site [nucleotide binding]; other site
243231010438	putative NADP binding site [chemical binding]; other site
243231010439	Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745
243231010440	porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072
243231010441	Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cd00494
243231010442	domain interfaces; other site
243231010443	active site
243231010444	Precorrin-3B methylase [Coenzyme metabolism]; Region: CobJ; cl00304
243231010445	Tetrapyrrole (Corrin/Porphyrin) Methylases; Region: TP_methylase; pfam00590
243231010446	Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578
243231010447	active site
243231010448	Uroporphyrinogen-III synthase HemD; Region: HEM4; pfam02602
243231010449	TatD like proteins;  E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310
243231010450	active site
243231010451	Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 1 [Coenzyme metabolism]; Region: COG1179
243231010452	Family of activating enzymes (E1) of ubiquitin-like proteins related to the E.coli hypothetical protein ygdL. The common reaction mechanism catalyzed by E1-like enzymes begins with a nucleophilic attack of the C-terminal carboxylate of the ubiquitin-like...; Region: YgdL_like; cd00755
243231010453	putative ATP binding site [chemical binding]; other site
243231010454	putative substrate interface [chemical binding]; other site
243231010455	Uncharacterized family of ferritin-like proteins found in archaea and bacteria; Region: Ferritin_like_AB; cd01045
243231010456	diiron binding motif [ion binding]; other site
243231010457	Zinc ribbon domain; Region: CxxC_CxxC_SSSS; cl00993
243231010458	Inorganic pyrophosphatase [Energy production and conversion]; Region: OVP1; cl11452
243231010459	membrane-bound proton-translocating pyrophosphatase; Validated; Region: hppA; PRK00733
243231010460	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153
243231010461	metal binding site 2 [ion binding]; metal-binding site
243231010462	putative DNA binding helix; other site
243231010463	metal binding site 1 [ion binding]; metal-binding site
243231010464	dimer interface [polypeptide binding]; other site
243231010465	structural Zn2+ binding site [ion binding]; other site
243231010466	Uncharacterized family of ferritin-like proteins found in archaea and bacteria; Region: Ferritin_like_AB; cd01045
243231010467	diiron binding motif [ion binding]; other site
243231010468	Uncharacterized flavoproteins [Energy production and conversion]; Region: FpaA; COG0426
243231010469	Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446
243231010470	NADPH-dependent FMN reductase; Region: FMN_red; cl00438
243231010471	Domain of unknown function (DUF2088); Region: DUF2088; cl15406
243231010472	FAD binding domain; Region: FAD_binding_4; pfam01565
243231010473	glycolate oxidase, subunit GlcD; Region: glcD; TIGR00387
243231010474	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
243231010475	Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247
243231010476	Cysteine-rich domain; Region: CCG; pfam02754
243231010477	Cysteine-rich domain; Region: CCG; pfam02754
243231010478	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
243231010479	sequence-specific DNA binding site [nucleotide binding]; other site
243231010480	salt bridge; other site
243231010481	Cupin domain; Region: Cupin_2; cl09118
243231010482	Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799
243231010483	Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl15772
243231010484	Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl15772
243231010485	Biotin carboxylase [Lipid metabolism]; Region: AccC; COG0439
243231010486	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
243231010487	Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770
243231010488	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; cl08365
243231010489	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
243231010490	carboxyltransferase (CT) interaction site; other site
243231010491	biotinylation site [posttranslational modification]; other site
243231010492	Thymidylate kinase [Nucleotide transport and metabolism]; Region: Tmk; COG0125
243231010493	Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672
243231010494	TMP-binding site; other site
243231010495	ATP-binding site [chemical binding]; other site
243231010496	Methylmalonyl-CoA mutase, N-terminal domain/subunit [Lipid metabolism]; Region: Sbm; COG1884
243231010497	Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM) family, isobutyryl-CoA mutase (ICM)-like subfamily; contains archaeal and bacterial proteins similar to the large subunit of Streptomyces cinnamonensis coenzyme B12-dependent ICM. ICM...; Region: MM_CoA_mutase_ICM_like; cd03680
243231010498	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
243231010499	Methylmalonyl-CoA epimerase (MMCE); Region: MMCE; cd07249
243231010500	dimer interface [polypeptide binding]; other site
243231010501	substrate binding site [chemical binding]; other site
243231010502	metal binding site [ion binding]; metal-binding site
243231010503	Family description; Region: VCBS; pfam13517
243231010504	ATP phosphoribosyltransferase regulatory subunit; Provisional; Region: hisZ; PRK12292
243231010505	Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: HisRS-like_core; cd00773
243231010506	dimer interface [polypeptide binding]; other site
243231010507	motif 1; other site
243231010508	active site
243231010509	motif 2; other site
243231010510	motif 3; other site
243231010511	HGTP anticodon binding domain, as found at the C-terminus of histidyl, glycyl, threonyl and prolyl tRNA synthetases, which are classified as a group of class II aminoacyl-tRNA synthetases (aaRS). In aaRSs, the anticodon binding domain is responsible for...; Region: HGTP_anticodon; cl00266
243231010512	anticodon binding site; other site
243231010513	Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788
243231010514	Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108
243231010515	GDP-binding site [chemical binding]; other site
243231010516	ACT binding site; other site
243231010517	IMP binding site; other site
243231010518	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
243231010519	Walker A motif; other site
243231010520	ATP binding site [chemical binding]; other site
243231010521	Walker B motif; other site
243231010522	arginine finger; other site
243231010523	Globin domain present in Globin-Coupled-Sensors (GCS). These domains detect changes in intracellular concentrations of oxygen, carbon monoxyde, or nitrous oxide,  which result in aerotaxis and/or gene regulation. One subgroup, the HemATs, are aerotactic...; Region: sensor_globin; cd01068
243231010524	heme-binding site [chemical binding]; other site
243231010525	Ferrochelatase; Region: Ferrochelatase; pfam00762
243231010526	Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411
243231010527	C-terminal domain interface [polypeptide binding]; other site
243231010528	active site
243231010529	Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419
243231010530	active site
243231010531	N-terminal domain interface [polypeptide binding]; other site
243231010532	Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2  has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829
243231010533	acetyl-CoA acetyltransferase; Provisional; Region: PRK06064
243231010534	active site
243231010535	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
243231010536	putative substrate translocation pore; other site
243231010537	Major Facilitator Superfamily; Region: MFS_1; pfam07690
243231010538	Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504
243231010539	Uncharacterized conserved protein [Function unknown]; Region: COG5316
243231010540	Domain of unknown function (DUF4139); Region: DUF4139; pfam13598
243231010541	peptidyl-prolyl cis-trans isomerase B (rotamase B); Provisional; Region: PRK10791
243231010542	cyclophilin_EcCYP_like: cyclophilin-type A-like peptidylprolyl cis- trans isomerase (PPIase) domain similar to the cytosolic E. coli cyclophilin A and Streptomyces antibioticus SanCyp18. Compared to the archetypal cyclophilin Human cyclophilin A, these...; Region: cyclophilin_EcCYP_like; cd01920
243231010543	substrate binding site [chemical binding]; other site
243231010544	Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912
243231010545	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
243231010546	S-adenosylmethionine binding site [chemical binding]; other site
243231010547	Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109
243231010548	This PGM-like (phosphoglucomutase-like) protein of unknown function belongs to the alpha-D-phosphohexomutase superfamily and is found in both archaea and bacteria. The alpha-D-phosphohexomutases include several related enzymes that catalyze a reversible...; Region: PGM_like2; cd05800
243231010549	active site
243231010550	substrate binding site [chemical binding]; other site
243231010551	metal binding site [ion binding]; metal-binding site
243231010552	Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598
243231010553	magnesium/nickel/cobalt transporter CorA; Provisional; Region: PRK11085; cl00459
243231010554	polyphosphate kinase; Provisional; Region: PRK05443
243231010555	Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089
243231010556	Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503
243231010557	Catalytic C-terminal domain, first repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C1_like; cd09165
243231010558	putative domain interface [polypeptide binding]; other site
243231010559	putative active site [active]
243231010560	catalytic site [active]
243231010561	Catalytic C-terminal domain, second repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C2_like; cd09168
243231010562	putative domain interface [polypeptide binding]; other site
243231010563	putative active site [active]
243231010564	catalytic site [active]
243231010565	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
243231010566	non-specific DNA binding site [nucleotide binding]; other site
243231010567	SOS-response transcriptional repressors (RecA-mediated autopeptidases) [Transcription / Signal transduction mechanisms]; Region: LexA; COG1974
243231010568	salt bridge; other site
243231010569	sequence-specific DNA binding site [nucleotide binding]; other site
243231010570	Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529
243231010571	Catalytic site [active]
243231010572	excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349
243231010573	The excision repair protein UvrA domain I; Nucleotide excision repair in eubacteria is a process that repairs DNA damage by the removal of a 12-13-mer oligonucleotide containing the lesion.  Recognition and cleavage of the damaged DNA is a multistep...; Region: ABC_UvrA_I; cd03270
243231010574	The excision repair protein UvrA domain I; Nucleotide excision repair in eubacteria is a process that repairs DNA damage by the removal of a 12-13-mer oligonucleotide containing the lesion.  Recognition and cleavage of the damaged DNA is a multistep...; Region: ABC_UvrA_I; cd03270
243231010575	The excision repair protein UvrA domain II; Nucleotide excision repair in eubacteria is a process that repairs DNA damage by the removal of a 12-13-mer oligonucleotide containing the lesion.  Recognition and cleavage of the damaged DNA is a multistep...; Region: ABC_UvrA_II; cd03271
243231010576	Protein of unknown function (DUF1847); Region: DUF1847; cl02037
243231010577	Protein of unknown function (DUF2288); Region: DUF2288; cl02399
243231010578	Domain of unknown function (DUF4130; Region: DUF4130; cl14836
243231010579	putative DNA modification/repair radical SAM protein; Region: rSAM_link_UDG; TIGR03916
243231010580	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
243231010581	FeS/SAM binding site; other site
243231010582	Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day.  Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN_family; cd02803
243231010583	active site
243231010584	FMN binding site [chemical binding]; other site
243231010585	substrate binding site [chemical binding]; other site
243231010586	putative catalytic residue [active]
243231010587	pyruvate kinase; Provisional; Region: PRK05826
243231010588	Pyruvate kinase (PK):  Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl09155
243231010589	domain interfaces; other site
243231010590	active site
243231010591	3-deoxy-7-phosphoheptulonate synthase; Reviewed; Region: PRK08673
243231010592	NeuB family; Region: NeuB; cl00496
243231010593	Cytochrome c; Region: Cytochrom_C; cl11414
243231010594	Protein of unknown function (DUF507); Region: DUF507; cl01112
243231010595	Protein of unknown function (DUF507); Region: DUF507; cl01112
243231010596	potential protein location (hypothetical protein) that overlaps protein (hypothetical protein)
243231010597	potential protein location (hypothetical protein) that overlaps protein (hypothetical protein)
243231010598	Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320
243231010599	oligomerisation interface [polypeptide binding]; other site
243231010600	mobile loop; other site
243231010601	roof hairpin; other site
243231010602	chaperonin GroEL; Reviewed; Region: groEL; PRK12849
243231010603	GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344
243231010604	ring oligomerisation interface [polypeptide binding]; other site
243231010605	ATP/Mg binding site [chemical binding]; other site
243231010606	stacking interactions; other site
243231010607	hinge regions; other site
243231010608	PrkA AAA domain; Region: AAA_PrkA; smart00763
243231010609	PrkA serine protein kinase C-terminal domain; Region: PrkA; pfam06798
243231010610	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057
243231010611	Uncharacterized conserved protein [Function unknown]; Region: SpoVR; COG2719
243231010612	SpoVR like protein; Region: SpoVR; pfam04293
243231010613	PrkA AAA domain; Region: AAA_PrkA; smart00763
243231010614	K+ potassium transporter; Region: K_trans; cl15781
243231010615	Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826
243231010616	Peptidase family U32; Region: Peptidase_U32; cl03113
243231010617	Collagenase; Region: DUF3656; pfam12392
243231010618	Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114
243231010619	Heat shock protein 33 (Hsp33):  Cytosolic protein that acts as a molecular chaperone under oxidative conditions.  In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498
243231010620	dimerization interface [polypeptide binding]; other site
243231010621	domain crossover interface; other site
243231010622	redox-dependent activation switch; other site
243231010623	Putative cyclase; Region: Cyclase; cl00814
243231010624	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
243231010625	dimer interface [polypeptide binding]; other site
243231010626	phosphorylation site [posttranslational modification]
243231010627	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
243231010628	ATP binding site [chemical binding]; other site
243231010629	Mg2+ binding site [ion binding]; other site
243231010630	G-X-G motif; other site
243231010631	Response regulator receiver domain; Region: Response_reg; pfam00072
243231010632	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
243231010633	active site
243231010634	phosphorylation site [posttranslational modification]
243231010635	intermolecular recognition site; other site
243231010636	dimerization interface [polypeptide binding]; other site
243231010637	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
243231010638	metal binding site [ion binding]; metal-binding site
243231010639	active site
243231010640	I-site; other site
243231010641	Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564
243231010642	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
243231010643	RNA binding surface [nucleotide binding]; other site
243231010644	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
243231010645	active site
243231010646	ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424
243231010647	dimer interface [polypeptide binding]; other site
243231010648	ADP-ribose binding site [chemical binding]; other site
243231010649	active site
243231010650	nudix motif; other site
243231010651	metal binding site [ion binding]; metal-binding site
243231010652	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054
243231010653	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
243231010654	metal binding site [ion binding]; metal-binding site
243231010655	active site
243231010656	I-site; other site
243231010657	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
243231010658	PAS domain S-box; Region: sensory_box; TIGR00229
243231010659	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
243231010660	putative active site [active]
243231010661	heme pocket [chemical binding]; other site
243231010662	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
243231010663	dimer interface [polypeptide binding]; other site
243231010664	phosphorylation site [posttranslational modification]
243231010665	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
243231010666	ATP binding site [chemical binding]; other site
243231010667	Mg2+ binding site [ion binding]; other site
243231010668	G-X-G motif; other site
243231010669	AAA ATPase containing von Willebrand factor type A (vWA) domain [General function prediction only]; Region: MDN1; COG5271
243231010670	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
243231010671	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
243231010672	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
243231010673	Transglutaminase-like superfamily; Region: Transglut_core; cl10469
243231010674	4Fe-4S binding domain; Region: Fer4; cl02805
243231010675	4Fe-4S dicluster domain; Region: Fer4_7; pfam12838
243231010676	4Fe-4S binding domain; Region: Fer4; cl02805
243231010677	Iron only hydrogenase large subunit, C-terminal domain; Region: Fe_hyd_lg_C; pfam02906
243231010678	Predicted NADH:ubiquinone oxidoreductase, subunit RnfB [Energy production and conversion]; Region: COG2878
243231010679	Putative Fe-S cluster; Region: FeS; pfam04060
243231010680	psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974
243231010681	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
243231010682	Walker A motif; other site
243231010683	ATP binding site [chemical binding]; other site
243231010684	Walker B motif; other site
243231010685	arginine finger; other site
243231010686	Helix-turn-helix domains; Region: HTH; cl00088
243231010687	Ribbon-helix-helix protein, copG family; Region: RHH_1; cl15783
243231010688	cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260
243231010689	catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672
243231010690	active site
243231010691	HIGH motif; other site
243231010692	catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672
243231010693	KMSKS motif; other site
243231010694	Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020
243231010695	tRNA binding surface [nucleotide binding]; other site
243231010696	anticodon binding site; other site
243231010697	glutaminyl-tRNA synthetase; Provisional; Region: PRK05347
243231010698	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
243231010699	active site
243231010700	HIGH motif; other site
243231010701	nucleotide binding site [chemical binding]; other site
243231010702	catalytic core domain of glutaminyl-tRNA synthetase; Region: GlnRS_core; cd00807
243231010703	KMSKS motif; other site
243231010704	tRNA synthetases class I (E and Q), anti-codon binding domain; Region: tRNA-synt_1c_C; pfam03950
243231010705	MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554
243231010706	homotrimer interaction site [polypeptide binding]; other site
243231010707	zinc binding site [ion binding]; other site
243231010708	CDP-binding sites; other site
243231010709	CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516
243231010710	substrate binding site; other site
243231010711	dimer interface; other site
243231010712	seryl-tRNA(sec) selenium transferase; Region: selA; TIGR00474
243231010713	Selenocysteine synthase N terminal; Region: Se-cys_synth_N; pfam12390
243231010714	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
243231010715	Transcriptional regulators [Transcription]; Region: GntR; COG1802
243231010716	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
243231010717	DNA-binding site [nucleotide binding]; DNA binding site
243231010718	FCD domain; Region: FCD; cl11656
243231010719	Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082
243231010720	AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060
243231010721	Metal-binding active site; metal-binding site
243231010722	cardiolipin synthetase; Reviewed; Region: cls; PRK01642
243231010723	Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396
243231010724	Putative catalytic domain, repeat 1, of uncharacterized proteins similar to bacterial cardiolipin synthase; Region: PLDc_CLS_unchar2_1; cd09157
243231010725	putative active site [active]
243231010726	catalytic site [active]
243231010727	Putative catalytic domain, repeat 2, of uncharacterized proteins similar to bacterial cardiolipin synthase; Region: PLDc_CLS_unchar2_2; cd09163
243231010728	putative active site [active]
243231010729	catalytic site [active]
243231010730	16S rRNA methyltransferase B; Provisional; Region: PRK14902
243231010731	RNA binding domain of NusB (N protein-Utilization Substance B) and Sun (also known as RrmB or Fmu) proteins. This family includes two orthologous groups exemplified by the transcription termination factor NusB and the N-terminal domain of the...; Region: NusB_Sun; cl00223
243231010732	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
243231010733	S-adenosylmethionine binding site [chemical binding]; other site
243231010734	Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429
243231010735	ribulose-phosphate 3-epimerase; Region: rpe; TIGR01163
243231010736	substrate binding site [chemical binding]; other site
243231010737	hexamer interface [polypeptide binding]; other site
243231010738	metal binding site [ion binding]; metal-binding site
243231010739	Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426
243231010740	putative active site [active]
243231010741	putative CoA binding site [chemical binding]; other site
243231010742	nudix motif; other site
243231010743	metal binding site [ion binding]; metal-binding site
243231010744	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
243231010745	Response regulator receiver domain; Region: Response_reg; pfam00072
243231010746	active site
243231010747	phosphorylation site [posttranslational modification]
243231010748	intermolecular recognition site; other site
243231010749	dimerization interface [polypeptide binding]; other site
243231010750	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
243231010751	metal binding site [ion binding]; metal-binding site
243231010752	active site
243231010753	I-site; other site
243231010754	Uncharacterized protein related to Endonuclease III [DNA replication, recombination, and repair]; Region: COG2231
243231010755	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
243231010756	minor groove reading motif; other site
243231010757	helix-hairpin-helix signature motif; other site
243231010758	substrate binding pocket [chemical binding]; other site
243231010759	active site
243231010760	Glutamine synthetase adenylyltransferase [Posttranslational modification, protein turnover, chaperones / Signal transduction mechanisms]; Region: GlnE; COG1391
243231010761	Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401
243231010762	metal binding triad; other site
243231010763	GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335
243231010764	Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401
243231010765	metal binding triad; other site
243231010766	GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335
243231010767	methylthioribose-1-phosphate isomerase; Reviewed; Region: mtnA; PRK05720
243231010768	Predicted translation initiation factor 2B subunit, eIF-2B alpha/beta/delta family [Translation, ribosomal structure and biogenesis]; Region: COG0182; cl00348
243231010769	aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477
243231010770	GatB/GatE catalytic domain; Region: GatB_N; pfam02934
243231010771	GatB domain; Region: GatB_Yqey; cl11497
243231010772	Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154
243231010773	Amidase; Region: Amidase; cl11426
243231010774	Glu-tRNAGln amidotransferase C subunit; Region: Glu-tRNAGln; cl00495
243231010775	Phosphatidylserine/phosphatidylglycerophosphate/car diolipin synthases and related enzymes [Lipid metabolism]; Region: Cls; COG1502
243231010776	Putative catalytic domain, repeat 1, of Escherichia coli uncharacterized protein ymdC and similar proteins; Region: PLDc_ymdC_like_1; cd09111
243231010777	putative active site [active]
243231010778	catalytic site [active]
243231010779	Putative catalytic domain, repeat 2, of Escherichia coli uncharacterized protein ymdC and similar proteins; Region: PLDc_ymdC_like_2; cd09113
243231010780	putative active site [active]
243231010781	catalytic site [active]
243231010782	Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_GTP; cd00819
243231010783	Phosphoenolpyruvate carboxykinase; Region: PEPCK; pfam00821
243231010784	active site
243231010785	substrate-binding site [chemical binding]; other site
243231010786	metal-binding site [ion binding]
243231010787	GTP binding site [chemical binding]; other site
243231010788	Cupin domain; Region: Cupin_2; cl09118
243231010789	Helix-turn-helix domain; Region: HTH_18; pfam12833
243231010790	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
243231010791	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
243231010792	EamA-like transporter family; Region: EamA; cl01037
243231010793	EamA-like transporter family; Region: EamA; cl01037
243231010794	FecR protein; Region: FecR; pfam04773
243231010795	Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950
243231010796	EamA-like transporter family; Region: EamA; cl01037
243231010797	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410
243231010798	LivF (TM1139) is part of the LIV-I bacterial ABC-type two-component transport system that imports neutral, branched-chain amino acids.  The  E. coli branched-chain amino acid transporter comprises a heterodimer of ABC transporters (LivF and LivG), a...; Region: ABC_TM1139_LivF_branched; cd03224
243231010799	Walker A/P-loop; other site
243231010800	ATP binding site [chemical binding]; other site
243231010801	Q-loop/lid; other site
243231010802	ABC transporter signature motif; other site
243231010803	Walker B; other site
243231010804	D-loop; other site
243231010805	H-loop/switch region; other site
243231010806	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411
243231010807	The Mj1267/LivG ABC transporter subfamily is involved in the transport of the hydrophobic amino acids leucine, isoleucine and valine.  MJ1267 is a branched-chain amino acid transporter with 29% similarity to both the LivF and LivG components of the E; Region: ABC_Mj1267_LivG_branched; cd03219
243231010808	Walker A/P-loop; other site
243231010809	ATP binding site [chemical binding]; other site
243231010810	Q-loop/lid; other site
243231010811	ABC transporter signature motif; other site
243231010812	Walker B; other site
243231010813	D-loop; other site
243231010814	H-loop/switch region; other site
243231010815	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
243231010816	TM-ABC transporter signature motif; other site
243231010817	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
243231010818	TM-ABC transporter signature motif; other site
243231010819	Proline dehydrogenase; Region: Pro_dh; cl03282
243231010820	1-pyrroline-5-carboxylate dehydrogenase; Provisional; Region: PRK03137
243231010821	Delta(1)-pyrroline-5-carboxylate dehydrogenase, RocA; Region: ALDH_PutA-P5CDH-RocA; cd07124
243231010822	Glutamate binding site [chemical binding]; other site
243231010823	homodimer interface [polypeptide binding]; other site
243231010824	NAD binding site [chemical binding]; other site
243231010825	catalytic residues [active]
243231010826	Transcriptional regulators [Transcription]; Region: FadR; COG2186
243231010827	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
243231010828	DNA-binding site [nucleotide binding]; DNA binding site
243231010829	FCD domain; Region: FCD; cl11656
243231010830	Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538
243231010831	FixH; Region: FixH; cl01254
243231010832	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
243231010833	Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404
243231010834	Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696
243231010835	Periplasmic binding protein; Region: Peripla_BP_6; pfam13458
243231010836	Type I periplasmic ligand-binding domain of uncharacterized ABC (Atpase Binding Cassette)-type active transport systems that are predicted to be involved in uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_12; cd06347
243231010837	putative ligand binding site [chemical binding]; other site
243231010838	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
243231010839	HisP and GlnQ are the ATP-binding components of the bacterial periplasmic histidine and glutamine permeases, repectively.  Histidine permease is a multisubunit complex containing the HisQ and HisM integral membrane subunits and two copies of HisP.  HisP...; Region: ABC_HisP_GlnQ_permeases; cd03262
243231010840	Walker A/P-loop; other site
243231010841	ATP binding site [chemical binding]; other site
243231010842	Q-loop/lid; other site
243231010843	ABC transporter signature motif; other site
243231010844	Walker B; other site
243231010845	D-loop; other site
243231010846	H-loop/switch region; other site
243231010847	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
243231010848	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
243231010849	dimer interface [polypeptide binding]; other site
243231010850	conserved gate region; other site
243231010851	putative PBP binding loops; other site
243231010852	ABC-ATPase subunit interface; other site
243231010853	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
243231010854	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
243231010855	substrate binding pocket [chemical binding]; other site
243231010856	membrane-bound complex binding site; other site
243231010857	hinge residues; other site
243231010858	EamA-like transporter family; Region: EamA; cl01037
243231010859	EamA-like transporter family; Region: EamA; cl01037
243231010860	Threonine aldolase [Amino acid transport and metabolism]; Region: GLY1; COG2008
243231010861	Low-specificity threonine aldolase (TA). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I).  TA catalyzes the conversion of L-threonine or L-allo-threonine to glycine and acetaldehyde in a...; Region: TA_like; cd06502
243231010862	tetramer interface [polypeptide binding]; other site
243231010863	pyridoxal 5'-phosphate binding site [chemical binding]; other site
243231010864	catalytic residue [active]
243231010865	ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073
243231010866	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
243231010867	Family description; Region: UvrD_C_2; cl15862
243231010868	Outer membrane lipoprotein carrier protein LolA; Region: LolA; cl01065
243231010869	B12 binding domain_like associated with radical SAM domain. This domain shows similarity with B12 (adenosylcobamide) binding domains found in several enzymes, such as glutamate mutase, methionine synthase and methylmalonyl-CoA mutase, but it lacks the...; Region: radical_SAM_B12_BD; cd02068
243231010870	Elongator protein 3, MiaB family, Radical SAM; Region: Elp3; smart00729
243231010871	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
243231010872	FeS/SAM binding site; other site
243231010873	Lipid A 3-O-deacylase (PagL); Region: PagL; pfam09411
243231010874	Lignostilbene-alpha,beta-dioxygenase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3670
243231010875	Retinal pigment epithelial membrane protein; Region: RPE65; cl10080
243231010876	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
243231010877	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
243231010878	active site
243231010879	phosphorylation site [posttranslational modification]
243231010880	intermolecular recognition site; other site
243231010881	dimerization interface [polypeptide binding]; other site
243231010882	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
243231010883	Walker A motif; other site
243231010884	ATP binding site [chemical binding]; other site
243231010885	Walker B motif; other site
243231010886	arginine finger; other site
243231010887	Helix-turn-helix domains; Region: HTH; cl00088
243231010888	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
243231010889	Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852
243231010890	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
243231010891	dimer interface [polypeptide binding]; other site
243231010892	phosphorylation site [posttranslational modification]
243231010893	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
243231010894	ATP binding site [chemical binding]; other site
243231010895	Mg2+ binding site [ion binding]; other site
243231010896	G-X-G motif; other site
243231010897	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984
243231010898	putative acyl-acceptor binding pocket; other site
243231010899	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
243231010900	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
243231010901	ligand binding site [chemical binding]; other site
243231010902	flexible hinge region; other site
243231010903	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092
243231010904	putative switch regulator; other site
243231010905	non-specific DNA interactions [nucleotide binding]; other site
243231010906	DNA binding site [nucleotide binding]
243231010907	sequence specific DNA binding site [nucleotide binding]; other site
243231010908	putative cAMP binding site [chemical binding]; other site
243231010909	DTW domain; Region: DTW; cl01221
243231010910	transketolase; Reviewed; Region: PRK05899
243231010911	Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012
243231010912	TPP-binding site [chemical binding]; other site
243231010913	dimer interface [polypeptide binding]; other site
243231010914	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
243231010915	PYR/PP interface [polypeptide binding]; other site
243231010916	dimer interface [polypeptide binding]; other site
243231010917	TPP binding site [chemical binding]; other site
243231010918	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
243231010919	mercuric reductase; Region: MerA; TIGR02053
243231010920	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
243231010921	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
243231010922	hypothetical protein; Provisional; Region: PRK09272
243231010923	Protein of unknown function (DUF3365); Region: DUF3365; pfam11845
243231010924	NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777
243231010925	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; cl14187
243231010926	NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846
243231010927	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; cl14187
243231010928	NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662
243231010929	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; cl14187
243231010930	NADH-ubiquinone/plastoquinone oxidoreductase chain 4L; Region: Oxidored_q2; cl00492
243231010931	NADH dehydrogenase subunit J; Provisional; Region: PRK06433; cl14634
243231010932	NADH:ubiquinone oxidoreductase subunit J; Provisional; Region: PRK06638
243231010933	NADH dehydrogenase subunit I; Provisional; Region: PRK05888
243231010934	4Fe-4S binding domain; Region: Fer4; cl02805
243231010935	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
243231010936	Ankyrin repeats (many copies); Region: Ank_4; pfam13637
243231010937	NADH dehydrogenase; Region: NADHdh; cl00469
243231010938	PAS domain; Region: PAS_9; pfam13426
243231010939	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
243231010940	putative active site [active]
243231010941	heme pocket [chemical binding]; other site
243231010942	GAF domain; Region: GAF; cl15785
243231010943	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
243231010944	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
243231010945	dimer interface [polypeptide binding]; other site
243231010946	phosphorylation site [posttranslational modification]
243231010947	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
243231010948	ATP binding site [chemical binding]; other site
243231010949	Mg2+ binding site [ion binding]; other site
243231010950	G-X-G motif; other site
243231010951	Uncharacterized Zn-ribbon-containing protein involved in phosphonate metabolism [Inorganic ion transport and metabolism]; Region: PhnA; COG2824
243231010952	PhnA Zinc-Ribbon; Region: PhnA_Zn_Ribbon; pfam08274
243231010953	PhnA protein; Region: PhnA; pfam03831
243231010954	NADH-quinone oxidoreductase, chain G; Region: NuoG; TIGR01973
243231010955	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
243231010956	catalytic loop [active]
243231010957	iron binding site [ion binding]; other site
243231010958	NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; cl11210
243231010959	MopB_NADH-Q-OR-NuoG2: The NuoG/Nad11/75-kDa subunit (second domain) of the NADH-quinone oxidoreductase (NADH-Q-OR)/respiratory complex I/NADH dehydrogenase-1 (NDH-1). The NADH-Q-OR is the first energy-transducting complex in the respiratory chains of...; Region: MopB_NADH-Q-OR-NuoG2; cd02768
243231010960	NADH-quinone oxidoreductase, F subunit; Region: nuoF_fam; TIGR01959
243231010961	SLBB domain; Region: SLBB; pfam10531
243231010962	NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; cl11211
243231010963	Protein of unknown function, DUF488; Region: DUF488; cl01246
243231010964	NADH:ubiquinone oxidoreductase 24 kD subunit [Energy production and conversion]; Region: NuoE; COG1905
243231010965	TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064
243231010966	putative dimer interface [polypeptide binding]; other site
243231010967	[2Fe-2S] cluster binding site [ion binding]; other site
243231010968	trifunctional NADH dehydrogenase I subunit B/C/D; Provisional; Region: PRK13292
243231010969	NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; cl15792
243231010970	Respiratory-chain NADH dehydrogenase, 30 Kd subunit; Region: Complex1_30kDa; cl16917
243231010971	Nickel-dependent hydrogenase; Region: NiFeSe_Hases; cl00417
243231010972	NADH-ubiquinone/plastoquinone oxidoreductase, chain 3; Region: Oxidored_q4; cl00535
243231010973	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
243231010974	catalytic residues [active]
243231010975	Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017
243231010976	catalytic triad [active]
243231010977	Acetokinase family; Region: Acetate_kinase; cl01029
243231010978	acetate kinase; Region: ackA; TIGR00016
243231010979	Protein of unknown function (DUF1271); Region: DUF1271; cl01443
243231010980	4Fe-4S single cluster domain; Region: Fer4_15; pfam13459
243231010981	Glutamate synthase domain 1 [Amino acid transport and metabolism]; Region: GltB; COG0067
243231010982	Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713
243231010983	active site
243231010984	dimer interface [polypeptide binding]; other site
243231010985	Glutamate synthase central domain; Region: Glu_syn_central; pfam04898
243231010986	Glutamate synthase domain 2 [Amino acid transport and metabolism]; Region: GltB; COG0069
243231010987	Glutamate synthase (GltS) FMN-binding domain.  GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808
243231010988	active site
243231010989	FMN binding site [chemical binding]; other site
243231010990	substrate binding site [chemical binding]; other site
243231010991	3Fe-4S cluster binding site [ion binding]; other site
243231010992	GXGXG domain. This domain of unknown function is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS),  in subunit C of tungsten formylmethanofuran dehydrogenase (FwdC) and in subunit C of molybdenum formylmethanofuran...; Region: GXGXG; cd00504
243231010993	domain_subunit interface; other site
243231010994	Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506
243231010995	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
243231010996	methyltransferase, MtaA/CmuA family; Region: mtaA_cmuA; TIGR01463
243231010997	Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717
243231010998	substrate binding site [chemical binding]; other site
243231010999	active site
243231011000	putative heme d1 biosynthesis radical SAM protein NirJ2; Region: rSAM_NirJ2; TIGR04055
243231011001	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
243231011002	FeS/SAM binding site; other site
243231011003	Domain of unknown function (DUF4008); Region: DUF4008; cl14869
243231011004	ABC-2 type transporter; Region: ABC2_membrane; cl11417
243231011005	Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487
243231011006	active site
243231011007	catalytic residues [active]
243231011008	metal binding site [ion binding]; metal-binding site
243231011009	Glycine cleavage system regulatory protein [Amino acid transport and metabolism]; Region: GcvR; COG2716
243231011010	ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141
243231011011	ACT domains that comprise the Glycine Cleavage System Transcriptional Repressor (GcvR) protein, and other related domains; Region: ACT_GcvR_2; cd04869
243231011012	potential protein location (hypothetical protein) that overlaps protein (hypothetical protein)
243231011013	potential protein location (hypothetical protein) that overlaps protein (hypothetical protein)
243231011014	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
243231011015	active site
243231011016	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
243231011017	active site
243231011018	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911
243231011019	tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192
243231011020	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
243231011021	GidA associated domain 3; Region: GIDA_assoc_3; pfam13932
243231011022	tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291
243231011023	GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396
243231011024	trmE is a tRNA modification GTPase; Region: trmE; cd04164
243231011025	G1 box; other site
243231011026	GTP/Mg2+ binding site [chemical binding]; other site
243231011027	Switch I region; other site
243231011028	G2 box; other site
243231011029	Switch II region; other site
243231011030	G3 box; other site
243231011031	G4 box; other site
243231011032	G5 box; other site
243231011033	Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631
243231011034	membrane protein insertase; Provisional; Region: PRK01318
243231011035	60Kd inner membrane protein; Region: 60KD_IMP; cl00489
243231011036	Haemolytic domain; Region: Haemolytic; cl00506