-- dump date 20120504_145247 -- class Genbank::misc_feature -- table misc_feature_note -- id note 983545000001 chromosomal replication initiation protein; Reviewed; Region: dnaA; PRK00149 983545000002 DnaA N-terminal domain; Region: DnaA_N; pfam11638 983545000003 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 983545000004 Walker A motif; other site 983545000005 ATP binding site [chemical binding]; other site 983545000006 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 983545000007 Walker B motif; other site 983545000008 arginine finger; other site 983545000009 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 983545000010 DnaA box-binding interface [nucleotide binding]; other site 983545000011 DNA polymerase III subunit beta; Validated; Region: PRK05643 983545000012 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 983545000013 putative DNA binding surface [nucleotide binding]; other site 983545000014 dimer interface [polypeptide binding]; other site 983545000015 beta-clamp/clamp loader binding surface; other site 983545000016 beta-clamp/translesion DNA polymerase binding surface; other site 983545000017 recombination protein F; Reviewed; Region: recF; PRK00064 983545000018 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 983545000019 Walker A/P-loop; other site 983545000020 ATP binding site [chemical binding]; other site 983545000021 Q-loop/lid; other site 983545000022 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 983545000023 ABC transporter signature motif; other site 983545000024 Walker B; other site 983545000025 D-loop; other site 983545000026 H-loop/switch region; other site 983545000027 DNA gyrase subunit B; Provisional; Region: gyrB; PRK14939 983545000028 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 983545000029 Mg2+ binding site [ion binding]; other site 983545000030 G-X-G motif; other site 983545000031 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 983545000032 anchoring element; other site 983545000033 dimer interface [polypeptide binding]; other site 983545000034 ATP binding site [chemical binding]; other site 983545000035 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 983545000036 active site 983545000037 putative metal-binding site [ion binding]; other site 983545000038 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 983545000039 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 983545000040 aspartate racemase; Region: asp_race; TIGR00035 983545000041 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 983545000042 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 983545000043 metal binding site [ion binding]; metal-binding site 983545000044 active site 983545000045 I-site; other site 983545000046 Early set domain associated with the catalytic domain of sugar utilizing enzymes at either the N or C terminus; Region: E_set; cl09101 983545000047 glycyl-tRNA synthetase subunit beta; Validated; Region: glyS; PRK01233 983545000048 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 983545000049 Class II Glycyl-tRNA synthetase (GlyRS) alpha subunit core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes and in arabidopsis. It is responsible for the...; Region: GlyRS_alpha_core; cd00733 983545000050 dimer interface [polypeptide binding]; other site 983545000051 motif 1; other site 983545000052 active site 983545000053 motif 2; other site 983545000054 motif 3; other site 983545000055 Methyladenine glycosylase; Region: Adenine_glyco; cl01059 983545000056 Protein of unknown function (DUF2489); Region: DUF2489; pfam10675 983545000057 Der GTPase activator (YihI); Region: YihI; cl01172 983545000058 Cytochrome c; Region: Cytochrom_C; cl11414 983545000059 Cytochrome c; Region: Cytochrom_C; cl11414 983545000060 Predicted GTPase [General function prediction only]; Region: COG0218 983545000061 YihA (EngB) GTPase family; Region: YihA_EngB; cd01876 983545000062 G1 box; other site 983545000063 GTP/Mg2+ binding site [chemical binding]; other site 983545000064 Switch I region; other site 983545000065 G2 box; other site 983545000066 G3 box; other site 983545000067 Switch II region; other site 983545000068 G4 box; other site 983545000069 G5 box; other site 983545000070 DNA polymerase I; Provisional; Region: PRK05755 983545000071 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 983545000072 active site 983545000073 metal binding site 1 [ion binding]; metal-binding site 983545000074 putative 5' ssDNA interaction site; other site 983545000075 metal binding site 3; metal-binding site 983545000076 metal binding site 2 [ion binding]; metal-binding site 983545000077 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 983545000078 putative DNA binding site [nucleotide binding]; other site 983545000079 putative metal binding site [ion binding]; other site 983545000080 DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase I and similar bacterial family-A DNA polymerases; Region: DNA_polA_I_Ecoli_like_exo; cd06139 983545000081 active site 983545000082 catalytic site [active] 983545000083 substrate binding site [chemical binding]; other site 983545000084 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 983545000085 active site 983545000086 DNA binding site [nucleotide binding] 983545000087 catalytic site [active] 983545000088 Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168 983545000089 Cation transport protein; Region: TrkH; cl10514 983545000090 conjugal transfer surface exclusion protein TraT; Provisional; Region: PRK13731 983545000091 Enterobacterial TraT complement resistance protein; Region: TraT; pfam05818 983545000092 Protein of unknown function VcgC/VcgE (DUF2780); Region: DUF2780; pfam11075 983545000093 potassium transporter peripheral membrane component; Reviewed; Region: trkA; PRK09496 983545000094 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 983545000095 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl15357 983545000096 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 983545000097 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl15357 983545000098 16S rRNA methyltransferase B; Provisional; Region: PRK10901 983545000099 RNA binding domain of NusB (N protein-Utilization Substance B) and Sun (also known as RrmB or Fmu) proteins. This family includes two orthologous groups exemplified by the transcription termination factor NusB and the N-terminal domain of the...; Region: NusB_Sun; cl00223 983545000100 putative RNA binding site [nucleotide binding]; other site 983545000101 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 983545000102 S-adenosylmethionine binding site [chemical binding]; other site 983545000103 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 983545000104 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 983545000105 putative active site [active] 983545000106 substrate binding site [chemical binding]; other site 983545000107 putative cosubstrate binding site; other site 983545000108 catalytic site [active] 983545000109 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 983545000110 substrate binding site [chemical binding]; other site 983545000111 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 983545000112 active site 983545000113 catalytic residues [active] 983545000114 metal binding site [ion binding]; metal-binding site 983545000115 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118 983545000116 putative peptidoglycan binding site; other site 983545000117 hypothetical protein; Provisional; Region: PRK10736 983545000118 Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695 983545000119 Protein of unknown function (DUF494); Region: DUF494; cl01103 983545000120 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 983545000121 Zn-finger domain associated with topoisomerase type I [DNA replication, recombination, and repair]; Region: TopA; COG0551 983545000122 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 983545000123 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 983545000124 Telomere recombination; Region: Sua5_yciO_yrdC; cl00305 983545000125 Coproporphyrinogen III oxidase; Region: Coprogen_oxidas; cl00433 983545000126 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; cl01155 983545000127 shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258 983545000128 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 983545000129 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 983545000130 shikimate binding site; other site 983545000131 NAD(P) binding site [chemical binding]; other site 983545000132 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 983545000133 Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645 983545000134 trimer interface [polypeptide binding]; other site 983545000135 putative metal binding site [ion binding]; other site 983545000136 error-prone DNA polymerase; Validated; Region: dnaE2; PRK05672 983545000137 Bacterial DNA polymerase III alpha subunit; Region: DNA_pol3_alpha; pfam07733 983545000138 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 983545000139 generic binding surface II; other site 983545000140 generic binding surface I; other site 983545000141 DNA Polymerase Y-family; Region: PolY_like; cd03468 983545000142 active site 983545000143 DNA binding site [nucleotide binding] 983545000144 Cell division inhibitor SulA; Region: SulA; cl01880 983545000145 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 983545000146 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 983545000147 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 983545000148 metal binding site [ion binding]; metal-binding site 983545000149 active site 983545000150 I-site; other site 983545000151 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383 983545000152 TonB-dependent receptor; Region: TonB-Xanth-Caul; TIGR01782 983545000153 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl00284 983545000154 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 983545000155 Homo sapiens acid phosphatase 5 and related proteins, metallophosphatase domain; Region: MPP_ACP5; cd07378 983545000156 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 983545000157 active site 983545000158 metal binding site [ion binding]; metal-binding site 983545000159 Phytase; Region: Phytase; pfam02333 983545000160 Phytase; Region: Phytase; pfam02333 983545000161 EVE domain; Region: EVE; cl00728 983545000162 Bacterial protein of unknown function (DUF885); Region: DUF885; pfam05960 983545000163 Domain of unknown function (DUF1820); Region: DUF1820; cl11545 983545000164 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 983545000165 PA_M28_1_1: Protease-associated (PA) domain, peptidase family M28, subfamily-1, subgroup 1. A subgroup of PA-domain containing proteins belonging to the peptidase family M28. Family M28 contains aminopeptidases and carboxypeptidases, and has co-catalytic...; Region: PA_M28_1_1; cd04820 983545000166 PA/protease or protease-like domain interface [polypeptide binding]; other site 983545000167 M28 Zn-Peptidases containing a PA domain insert; Region: M28_like_PA_2; cd05661 983545000168 metal binding site [ion binding]; metal-binding site 983545000169 Bacterial protein of unknown function (DUF885); Region: DUF885; pfam05960 983545000170 division inhibitor protein; Provisional; Region: slmA; PRK09480 983545000171 Helix-turn-helix domains; Region: HTH; cl00088 983545000172 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 983545000173 Flavoprotein; Region: Flavoprotein; cl08021 983545000174 DNA / pantothenate metabolism flavoprotein; Region: DFP; cl04410 983545000175 hypothetical protein; Reviewed; Region: PRK00024 983545000176 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 983545000177 MPN+ (JAMM) motif; other site 983545000178 Zinc-binding site [ion binding]; other site 983545000179 N-terminal domain of Chondroitin polymerase functions as a GalNAc transferase; Region: GT2_Chondriotin_Pol_N; cd06420 983545000180 Substrate binding site; other site 983545000181 metal-binding site 983545000182 Ribosomal L28 family; Region: Ribosomal_L28; cl00367 983545000183 Ribosomal protein L33; Region: Ribosomal_L33; cl00383 983545000184 formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103 983545000185 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 983545000186 DNA binding site [nucleotide binding] 983545000187 catalytic residue [active] 983545000188 H2TH interface [polypeptide binding]; other site 983545000189 putative catalytic residues [active] 983545000190 turnover-facilitating residue; other site 983545000191 intercalation triad [nucleotide binding]; other site 983545000192 8OG recognition residue [nucleotide binding]; other site 983545000193 putative reading head residues; other site 983545000194 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 983545000195 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 983545000196 Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887 983545000197 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 983545000198 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 983545000199 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 983545000200 active site 983545000201 (T/H)XGH motif; other site 983545000202 Capsule assembly protein Wzi; Region: Caps_assemb_Wzi; pfam14052 983545000203 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 983545000204 ATP binding site [chemical binding]; other site 983545000205 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 983545000206 3-deoxy-D-manno-octulosonic-acid transferase [Cell envelope biogenesis, outer membrane]; Region: KdtA; COG1519 983545000207 3-Deoxy-D-manno-octulosonic-acid transferase (kdotransferase); Region: Glycos_transf_N; pfam04413 983545000208 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 983545000209 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 983545000210 metal binding site [ion binding]; metal-binding site 983545000211 active site 983545000212 I-site; other site 983545000213 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 983545000214 7-keto-8-aminopelargonate synthetase and related enzymes [Coenzyme metabolism]; Region: BioF; COG0156 983545000215 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454 983545000216 substrate-cofactor binding pocket; other site 983545000217 pyridoxal 5'-phosphate binding site [chemical binding]; other site 983545000218 catalytic residue [active] 983545000219 L-threonine 3-dehydrogenase; Validated; Region: tdh; PRK05396 983545000220 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 983545000221 NAD(P) binding site [chemical binding]; other site 983545000222 GlpE sulfurtransferase (ST) and homologs are members of the Rhodanese Homology Domain superfamily. Unlike other rhodanese sulfurtransferases, GlpE is a single domain protein but indications are that it functions as a dimer. The active site contains a...; Region: GlpE_ST; cd01444 983545000223 active site residue [active] 983545000224 Protein of unknown function (DUF3582); Region: DUF3582; pfam12122 983545000225 intramembrane serine protease GlpG; Provisional; Region: PRK10907 983545000226 Rhomboid family; Region: Rhomboid; cl11446 983545000227 Flagellar basal body-associated protein FliL; Region: FliL; cl00681 983545000228 UTRA domain; Region: UTRA; cl01230 983545000229 UbiA prenyltransferase family; Region: UbiA; cl00337 983545000230 Signal transduction histidine kinase involved in nitrogen fixation and metabolism regulation [Signal transduction mechanisms]; Region: NtrY; COG5000 983545000231 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 983545000232 dimerization interface [polypeptide binding]; other site 983545000233 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 983545000234 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 983545000235 dimer interface [polypeptide binding]; other site 983545000236 putative CheW interface [polypeptide binding]; other site 983545000237 Membrane fusogenic activity; Region: BMFP; cl01115 983545000238 ATP-dependent DNA helicase Rep; Provisional; Region: PRK10919 983545000239 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 983545000240 Family description; Region: UvrD_C_2; cl15862 983545000241 GAF domain; Region: GAF; cl15785 983545000242 GAF domain; Region: GAF_2; pfam13185 983545000243 GAF domain; Region: GAF; cl15785 983545000244 GAF domain; Region: GAF_2; pfam13185 983545000245 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 983545000246 metal binding site [ion binding]; metal-binding site 983545000247 active site 983545000248 I-site; other site 983545000249 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 983545000250 Cytochrome c; Region: Cytochrom_C; cl11414 983545000251 DNA ligase; Provisional; Region: PRK09125 983545000252 Adenylation domain of kDNA ligases and similar proteins; Region: Adenylation_kDNA_ligase_like; cd07896 983545000253 DNA binding site [nucleotide binding] 983545000254 active site 983545000255 The Oligonucleotide/oligosaccharide binding (OB)-fold domain of kDNA ligase-like ATP-dependent DNA ligases is a DNA-binding module that is part of the catalytic core unit; Region: OBF_kDNA_ligase_like; cd08041 983545000256 DNA binding site [nucleotide binding] 983545000257 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 983545000258 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 983545000259 Bacterial Fe(2+) trafficking; Region: Iron_traffic; cl01104 983545000260 adenine DNA glycosylase; Provisional; Region: PRK10880 983545000261 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 983545000262 minor groove reading motif; other site 983545000263 helix-hairpin-helix signature motif; other site 983545000264 substrate binding pocket [chemical binding]; other site 983545000265 active site 983545000266 Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; cl15304 983545000267 DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431 983545000268 DNA binding and oxoG recognition site [nucleotide binding] 983545000269 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 983545000270 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl15754 983545000271 Methyltransferase domain; Region: Methyltransf_31; pfam13847 983545000272 16S ribosomal RNA m2G1207 methyltransferase; Provisional; Region: rsmC; PRK09489 983545000273 Methyltransferase small domain N-terminal; Region: MTS_N; pfam08468 983545000274 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 983545000275 glycogen synthase; Provisional; Region: glgA; PRK00654 983545000276 This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791 983545000277 ADP-binding pocket [chemical binding]; other site 983545000278 homodimer interface [polypeptide binding]; other site 983545000279 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: VicK; COG5002 983545000280 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 983545000281 sensor protein ZraS; Provisional; Region: PRK10364 983545000282 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 983545000283 dimer interface [polypeptide binding]; other site 983545000284 phosphorylation site [posttranslational modification] 983545000285 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 983545000286 ATP binding site [chemical binding]; other site 983545000287 G-X-G motif; other site 983545000288 two-component response regulator; Provisional; Region: PRK11173 983545000289 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 983545000290 active site 983545000291 phosphorylation site [posttranslational modification] 983545000292 intermolecular recognition site; other site 983545000293 dimerization interface [polypeptide binding]; other site 983545000294 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 983545000295 DNA binding site [nucleotide binding] 983545000296 FxsA cytoplasmic membrane protein; Region: FxsA; cl01148 983545000297 thiol:disulfide interchange protein precursor; Provisional; Region: dipZ; PRK00293 983545000298 Disulphide bond corrector protein DsbC; Region: DsbC; cl15830 983545000299 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 983545000300 DsbD gamma family; DsbD gamma is the C-terminal periplasmic domain of the bacterial protein DsbD. It contains a CXXC motif in a TRX fold and shuttles the reducing potential from the membrane domain (DsbD beta) to the N-terminal periplasmic domain (DsbD...; Region: DsbDgamma; cd02953 983545000301 DsbD alpha interface [polypeptide binding]; other site 983545000302 catalytic residues [active] 983545000303 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 983545000304 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 983545000305 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 983545000306 active site 983545000307 Protein of unknown function, DUF479; Region: DUF479; cl01203 983545000308 Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466 983545000309 trimer interface [polypeptide binding]; other site 983545000310 active site 983545000311 dimer interface [polypeptide binding]; other site 983545000312 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302 983545000313 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 983545000314 carboxyltransferase (CT) interaction site; other site 983545000315 biotinylation site [posttranslational modification]; other site 983545000316 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 983545000317 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 983545000318 ATP-grasp domain; Region: ATP-grasp_4; cl03087 983545000319 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; cl08365 983545000320 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 983545000321 MatE; Region: MatE; cl10513 983545000322 MatE; Region: MatE; cl10513 983545000323 Ribosomal protein L11 methyltransferase (PrmA); Region: PrmA; pfam06325 983545000324 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 983545000325 S-adenosylmethionine binding site [chemical binding]; other site 983545000326 Helix-turn-helix domains; Region: HTH; cl00088 983545000327 PEP-CTERM motif; Region: VPEP; cl15443 983545000328 Laminarinase, member of the glycosyl hydrolase family 16; Region: GH16_laminarinase_like; cd08023 983545000329 active site 983545000330 catalytic residues [active] 983545000331 Carbohydrate binding domain; Region: CBM_4_9; pfam02018 983545000332 Laminarinase, member of the glycosyl hydrolase family 16; Region: GH16_laminarinase_like; cd08023 983545000333 active site 983545000334 catalytic residues [active] 983545000335 Carbohydrate binding domain; Region: CBM_4_9; pfam02018 983545000336 nuc_hydro: Nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base. These enzymes vary in their substrate specificity. This group contains eukaryotic, bacterial and archeal...; Region: nuc_hydro; cl00226 983545000337 active site 983545000338 Helix-turn-helix domains; Region: HTH; cl00088 983545000339 OsmC-like protein; Region: OsmC; cl00767 983545000340 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 983545000341 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 983545000342 Walker A motif; other site 983545000343 ATP binding site [chemical binding]; other site 983545000344 Walker B motif; other site 983545000345 arginine finger; other site 983545000346 Protein containing von Willebrand factor type A (vWA) domain [General function prediction only]; Region: CoxE; COG3552 983545000347 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 983545000348 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 983545000349 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_2; cd03138 983545000350 conserved cys residue [active] 983545000351 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 983545000352 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 983545000353 pimeloyl-CoA dehydrogenase, large subunit; Region: pimC_large; TIGR03204 983545000354 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 983545000355 active site 983545000356 pimeloyl-CoA dehydrogenase, small subunit; Region: pimD_small; TIGR03203 983545000357 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 983545000358 active site 983545000359 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 983545000360 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 983545000361 N-terminal plug; other site 983545000362 ligand-binding site [chemical binding]; other site 983545000363 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 983545000364 Major Facilitator Superfamily; Region: MFS_1; pfam07690 983545000365 putative substrate translocation pore; other site 983545000366 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 983545000367 dimerization interface [polypeptide binding]; other site 983545000368 putative DNA binding site [nucleotide binding]; other site 983545000369 putative Zn2+ binding site [ion binding]; other site 983545000370 Predicted permease; Region: DUF318; pfam03773 983545000371 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 983545000372 Dienelactone hydrolase family; Region: DLH; pfam01738 983545000373 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 983545000374 Formyl transferase catalytic core domain found in a group of proteins with unknown functions; Region: FMT_core_like_3; cd08653 983545000375 putative active site [active] 983545000376 putative cosubstrate binding site; other site 983545000377 putative substrate binding site [chemical binding]; other site 983545000378 catalytic site [active] 983545000379 Polyphosphate kinase 2 (PPK2); Region: PPK2; cl11971 983545000380 Patatin-like phospholipase; includes PNPLA8, PNPLA9, and Pat17; Region: Pat17_PNPLA8_PNPLA9_like; cd07199 983545000381 active site 983545000382 nucleophile elbow; other site 983545000383 Serine-pyruvate aminotransferase/archaeal aspartate aminotransferase [Amino acid transport and metabolism]; Region: COG0075 983545000384 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 983545000385 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 983545000386 catalytic residue [active] 983545000387 Uncharacterized conserved protein [Function unknown]; Region: COG1284 983545000388 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_18; cd08357 983545000389 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 983545000390 putative metal binding site [ion binding]; other site 983545000391 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 983545000392 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 983545000393 GDP-binding site [chemical binding]; other site 983545000394 ACT binding site; other site 983545000395 IMP binding site; other site 983545000396 Uncharacterized protein conserved in bacteria (DUF2065); Region: DUF2065; cl01275 983545000397 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 983545000398 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 983545000399 dimer interface [polypeptide binding]; other site 983545000400 phosphorylation site [posttranslational modification] 983545000401 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 983545000402 ATP binding site [chemical binding]; other site 983545000403 Mg2+ binding site [ion binding]; other site 983545000404 G-X-G motif; other site 983545000405 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 983545000406 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 983545000407 active site 983545000408 phosphorylation site [posttranslational modification] 983545000409 intermolecular recognition site; other site 983545000410 dimerization interface [polypeptide binding]; other site 983545000411 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 983545000412 DNA binding site [nucleotide binding] 983545000413 Spondin_N; Region: Spond_N; pfam06468 983545000414 Spondin_N; Region: Spond_N; pfam06468 983545000415 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 983545000416 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cd03873 983545000417 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cd03873 983545000418 metal binding site [ion binding]; metal-binding site 983545000419 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 983545000420 osmolarity response regulator; Provisional; Region: ompR; PRK09468 983545000421 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 983545000422 active site 983545000423 phosphorylation site [posttranslational modification] 983545000424 intermolecular recognition site; other site 983545000425 dimerization interface [polypeptide binding]; other site 983545000426 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 983545000427 DNA binding site [nucleotide binding] 983545000428 osmolarity sensor protein; Provisional; Region: envZ; PRK09467 983545000429 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 983545000430 dimerization interface [polypeptide binding]; other site 983545000431 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 983545000432 dimer interface [polypeptide binding]; other site 983545000433 phosphorylation site [posttranslational modification] 983545000434 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 983545000435 ATP binding site [chemical binding]; other site 983545000436 Mg2+ binding site [ion binding]; other site 983545000437 G-X-G motif; other site 983545000438 Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114 983545000439 Heat shock protein 33 (Hsp33): Cytosolic protein that acts as a molecular chaperone under oxidative conditions. In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498 983545000440 dimerization interface [polypeptide binding]; other site 983545000441 domain crossover interface; other site 983545000442 redox-dependent activation switch; other site 983545000443 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 983545000444 RNA binding surface [nucleotide binding]; other site 983545000445 short chain dehydrogenase; Provisional; Region: PRK06123 983545000446 carbonyl reductase sniffer-like, classical (c) SDRs; Region: carb_red_sniffer_like_SDR_c; cd05325 983545000447 NADP binding site [chemical binding]; other site 983545000448 homodimer interface [polypeptide binding]; other site 983545000449 active site 983545000450 Type IV pilus biogenesis; Region: Pilus_PilP; cl11837 983545000451 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 983545000452 general secretion pathway protein D; Region: type_II_gspD; TIGR02517 983545000453 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 983545000454 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 983545000455 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 983545000456 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 983545000457 general secretory pathway protein E; Region: type_II_gspE; TIGR02533 983545000458 PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129 983545000459 Walker A motif; other site 983545000460 ATP binding site [chemical binding]; other site 983545000461 Walker B motif; other site 983545000462 general secretion pathway protein F; Region: GspF; TIGR02120 983545000463 Type II secretion system (T2SS), protein F; Region: T2SF; cl00906 983545000464 Type II secretion system (T2SS), protein F; Region: T2SF; cl00906 983545000465 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; cl06830 983545000466 general secretion pathway protein G; Region: typeII_sec_gspG; TIGR01710 983545000467 Type II secretion system (T2SS), protein G; Region: T2SG; pfam08334 983545000468 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; cl06830 983545000469 general secretion pathway protein H; Region: typeII_sec_gspH; TIGR01708 983545000470 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; cl06830 983545000471 general secretion pathway protein I; Region: gspI; TIGR01707 983545000472 Type II secretion system (T2SS), protein I; Region: T2SI; pfam02501 983545000473 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; cl06830 983545000474 general secretion pathway protein J; Region: gspJ; TIGR01711 983545000475 Type II secretion system (T2SS), protein J; Region: T2SJ; pfam11612 983545000476 Type II secretion system (T2SS), protein K; Region: T2SK; pfam03934 983545000477 general secretion pathway protein L; Region: typeII_sec_gspL; TIGR01709 983545000478 Type II secretion system (T2SS), protein L; Region: T2SL; pfam05134 983545000479 GspL periplasmic domain; Region: GspL_C; cl14909 983545000480 Type II secretion system (T2SS), protein M; Region: T2SM; cl01222 983545000481 Type II secretion system (T2SS), protein N; Region: T2SN; pfam01203 983545000482 Fructose-1,6-bisphosphatase, an enzyme that catalyzes the hydrolysis of fructose-1,6-biphosphate into fructose-6-phosphate and is critical in gluconeogenesis pathway. The alignment model also includes chloroplastic FBPases and sedoheptulose-1; Region: FBPase; cd00354 983545000483 AMP binding site [chemical binding]; other site 983545000484 metal binding site [ion binding]; metal-binding site 983545000485 active site 983545000486 UDP-N-acetylmuramate:L-alanyl-gamma-D-glutamyl- meso-diaminopimelate ligase; Region: mpl; TIGR01081 983545000487 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 983545000488 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 983545000489 S1/P1 Nuclease; Region: S1-P1_nuclease; pfam02265 983545000490 methyltransferase, MtaA/CmuA family; Region: mtaA_cmuA; TIGR01463 983545000491 Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717 983545000492 substrate binding site [chemical binding]; other site 983545000493 active site 983545000494 NADH pyrophosphatase zinc ribbon domain; Region: zf-NADH-PPase; pfam09297 983545000495 NADH pyrophosphatase, a member of the Nudix hydrolase superfamily, catalyzes the cleavage of NADH into reduced nicotinamide mononucleotide (NMNH) and AMP. Like other members of the Nudix family, it requires a divalent cation, such as Mg2+ or Mn2+, for...; Region: NADH_pyrophosphatase; cd03429 983545000496 putative NADH binding site [chemical binding]; other site 983545000497 putative active site [active] 983545000498 nudix motif; other site 983545000499 putative metal binding site [ion binding]; other site 983545000500 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 983545000501 metal binding site 2 [ion binding]; metal-binding site 983545000502 putative DNA binding helix; other site 983545000503 metal binding site 1 [ion binding]; metal-binding site 983545000504 dimer interface [polypeptide binding]; other site 983545000505 structural Zn2+ binding site [ion binding]; other site 983545000506 Predicted inhibitor of MCP methylation, homolog of CheC [Cell motility and secretion]; Region: COG1406 983545000507 Chemotaxis phosphatase CheX; Region: CheX; cl15816 983545000508 Uncharacterized protein family UPF0047; Region: UPF0047; cl00439 983545000509 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; cl01155 983545000510 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 983545000511 ligand binding site [chemical binding]; other site 983545000512 replicative DNA helicase; Region: DnaB; TIGR00665 983545000513 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 983545000514 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 983545000515 Walker A motif; other site 983545000516 ATP binding site [chemical binding]; other site 983545000517 Walker B motif; other site 983545000518 DNA binding loops [nucleotide binding] 983545000519 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 983545000520 ATP-dependent DNA helicase RecQ; Provisional; Region: PRK11057 983545000521 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 983545000522 ATP binding site [chemical binding]; other site 983545000523 ATP binding site [chemical binding]; other site 983545000524 putative Mg++ binding site [ion binding]; other site 983545000525 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 983545000526 nucleotide binding region [chemical binding]; other site 983545000527 ATP-binding site [chemical binding]; other site 983545000528 RQC domain; Region: RQC; cl09632 983545000529 HRDC domain; Region: HRDC; cl02578 983545000530 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 983545000531 CoenzymeA binding site [chemical binding]; other site 983545000532 subunit interaction site [polypeptide binding]; other site 983545000533 PHB binding site; other site 983545000534 Truncated hemoglobins (trHbs) are a family of oxygen-binding heme proteins found in cyanobacteria, eubacteria, unicellular eukaryotes, and plants. The truncated hemoglobins have a characteristic two-over-two alpha helical folding pattern that is distinct...; Region: Trunc_globin; cd00454 983545000535 apolar tunnel; other site 983545000536 heme binding site [chemical binding]; other site 983545000537 dimerization interface [polypeptide binding]; other site 983545000538 Protein of unknown function (DUF3034); Region: DUF3034; pfam11231 983545000539 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 983545000540 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 983545000541 metal binding site [ion binding]; metal-binding site 983545000542 active site 983545000543 I-site; other site 983545000544 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 983545000545 Mechanosensitive ion channel; Region: MS_channel; pfam00924 983545000546 Mechanosensitive ion channel; Region: MS_channel; pfam00924 983545000547 Outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG0729 983545000548 Surface antigen; Region: Bac_surface_Ag; cl03097 983545000549 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2911 983545000550 Family of unknown function (DUF490); Region: DUF490; pfam04357 983545000551 Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239 983545000552 MgtE intracellular N domain; Region: MgtE_N; cl15244 983545000553 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 983545000554 Divalent cation transporter; Region: MgtE; cl00786 983545000555 BON domain; Region: BON; cl02771 983545000556 BON domain; Region: BON; cl02771 983545000557 Response regulator receiver domain; Region: Response_reg; pfam00072 983545000558 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 983545000559 active site 983545000560 phosphorylation site [posttranslational modification] 983545000561 intermolecular recognition site; other site 983545000562 dimerization interface [polypeptide binding]; other site 983545000563 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 983545000564 metal binding site [ion binding]; metal-binding site 983545000565 active site 983545000566 I-site; other site 983545000567 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 983545000568 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 983545000569 ATP-grasp domain; Region: ATP-grasp_4; cl03087 983545000570 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 983545000571 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 983545000572 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 983545000573 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 983545000574 purine monophosphate binding site [chemical binding]; other site 983545000575 dimer interface [polypeptide binding]; other site 983545000576 putative catalytic residues [active] 983545000577 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 983545000578 Helix-turn-helix domains; Region: HTH; cl00088 983545000579 tRNA-dihydrouridine synthase B; Provisional; Region: PRK10415 983545000580 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 983545000581 FMN binding site [chemical binding]; other site 983545000582 active site 983545000583 catalytic residues [active] 983545000584 substrate binding site [chemical binding]; other site 983545000585 Protein of unknown function (DUF962); Region: DUF962; cl01879 983545000586 Thioredoxin domain-containing protein [Posttranslational modification, protein turnover, chaperones]; Region: COG3118 983545000587 ybbN protein family; ybbN is a hypothetical protein containing a redox-inactive TRX-like domain. Its gene has been sequenced from several gammaproteobacteria and actinobacteria; Region: ybbN; cd02956 983545000588 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 983545000589 binding surface 983545000590 TPR motif; other site 983545000591 Transcriptional regulator [Transcription]; Region: LysR; COG0583 983545000592 Helix-turn-helix domains; Region: HTH; cl00088 983545000593 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 983545000594 putative effector binding pocket; other site 983545000595 dimerization interface [polypeptide binding]; other site 983545000596 Peroxiredoxin (PRX)-like 2 family; hypothetical proteins that show sequence similarity to PRXs. Members of this group contain a CXXC motif, similar to TRX. The second cysteine in the motif corresponds to the peroxidatic cysteine of PRX, however, these...; Region: PRX_like2; cd02970 983545000597 putative catalytic residues [active] 983545000598 2-haloalkanoic acid dehalogenase, type II; Region: HAD_type_II; TIGR01428 983545000599 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 983545000600 motif II; other site 983545000601 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 983545000602 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 983545000603 substrate binding pocket [chemical binding]; other site 983545000604 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 983545000605 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 983545000606 Predicted deacylase [General function prediction only]; Region: COG3608 983545000607 M14 family of metallocarboxypeptidases and related proteins; Region: Peptidase_M14_like; cl11393 983545000608 active site 983545000609 Zn binding site [ion binding]; other site 983545000610 Protein of unknown function (DUF3703); Region: DUF3703; pfam12487 983545000611 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cl00264 983545000612 Conserved TM helix; Region: TM_helix; pfam05552 983545000613 mechanosensitive channel MscS; Provisional; Region: PRK10334 983545000614 Mechanosensitive ion channel; Region: MS_channel; pfam00924 983545000615 hypothetical protein; Provisional; Region: PRK12361 983545000616 Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr; Region: PTPc; cl00053 983545000617 active site 983545000618 catalytic residues [active] 983545000619 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; cl01255 983545000620 Peroxiredoxin (PRX)-like 2 family; hypothetical proteins that show sequence similarity to PRXs. Members of this group contain a CXXC motif, similar to TRX. The second cysteine in the motif corresponds to the peroxidatic cysteine of PRX, however, these...; Region: PRX_like2; cd02970 983545000621 putative catalytic residues [active] 983545000622 Hemerythrin (Hr) is a non-heme diiron oxygen transport protein found in four marine invertebrate phyla including priapulida, brachiopoda, sipunculida, and annelida, as well as in protozoa. Myohemerythrin (Mhr), a hemerythrin homolog, is found in the...; Region: Hemerythrin; cl15774 983545000623 Predicted membrane protein (DUF2177); Region: DUF2177; cl02014 983545000624 Formate/nitrite transporter; Region: Form_Nir_trans; cl00927 983545000625 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 983545000626 putative chloramphenical resistance permease RarD; Provisional; Region: PRK15430 983545000627 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 983545000628 Response regulator receiver domain; Region: Response_reg; pfam00072 983545000629 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 983545000630 active site 983545000631 phosphorylation site [posttranslational modification] 983545000632 intermolecular recognition site; other site 983545000633 dimerization interface [polypeptide binding]; other site 983545000634 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 983545000635 metal binding site [ion binding]; metal-binding site 983545000636 active site 983545000637 I-site; other site 983545000638 DNA-dependent helicase II; Provisional; Region: uvrD; PRK11773 983545000639 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 983545000640 Family description; Region: UvrD_C_2; cl15862 983545000641 serine acetyltransferase; Provisional; Region: cysE; PRK11132 983545000642 Serine acetyltransferase, N-terminal; Region: SATase_N; cl05762 983545000643 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 983545000644 trimer interface [polypeptide binding]; other site 983545000645 active site 983545000646 substrate binding site [chemical binding]; other site 983545000647 CoA binding site [chemical binding]; other site 983545000648 flavin mononucleotide phosphatase; Provisional; Region: PRK10748 983545000649 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 983545000650 motif II; other site 983545000651 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 983545000652 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 983545000653 DNA binding site [nucleotide binding] 983545000654 Int/Topo IB signature motif; other site 983545000655 active site 983545000656 GAF domain; Region: GAF; cl15785 983545000657 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 983545000658 Diaminopimelate epimerase; Region: DAP_epimerase; cl14668 983545000659 Diaminopimelate epimerase; Region: DAP_epimerase; cl14668 983545000660 diaminopimelate decarboxylase; Region: lysA; TIGR01048 983545000661 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 983545000662 active site 983545000663 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 983545000664 substrate binding site [chemical binding]; other site 983545000665 catalytic residues [active] 983545000666 dimer interface [polypeptide binding]; other site 983545000667 Glycosyl transferase family 1; Region: Glyco_trans_1_3; pfam13528 983545000668 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474 983545000669 active site 983545000670 Demethylmenaquinone methyltransferase; Region: Methyltransf_6; cl00480 983545000671 Biopolymer transport protein ExbD/TolR; Region: ExbD; cl00537 983545000672 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 983545000673 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 983545000674 beta-D-galactosidase; Reviewed; Region: lacZ; PRK09525 983545000675 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; cl08371 983545000676 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 983545000677 Cellulase (glycosyl hydrolase family 5); Region: Cellulase; cl15381 983545000678 Beta galactosidase small chain; Region: Bgal_small_N; cl03787 983545000679 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3204 983545000680 Peptide methionine sulfoxide reductase; Region: PMSR; cl00366 983545000681 Protein of unknown function, DUF393; Region: DUF393; cl01136 983545000682 carbonyl reductase sniffer-like, classical (c) SDRs; Region: carb_red_sniffer_like_SDR_c; cd05325 983545000683 sepiapterin reductase; Region: sepiapter_red; TIGR01500 983545000684 NADP binding site [chemical binding]; other site 983545000685 homodimer interface [polypeptide binding]; other site 983545000686 active site 983545000687 Sodium:neurotransmitter symporter family; Region: SNF; cl11976 983545000688 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 983545000689 NAD(P) binding site [chemical binding]; other site 983545000690 active site 983545000691 Protein of unknown function (DUF2884); Region: DUF2884; cl08135 983545000692 Mechanosensitive ion channel; Region: MS_channel; pfam00924 983545000693 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LCLAT1-like; Region: LPLAT_LCLAT1-like; cd07990 983545000694 putative acyl-acceptor binding pocket; other site 983545000695 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 983545000696 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LCLAT1-like; Region: LPLAT_LCLAT1-like; cd07990 983545000697 putative acyl-acceptor binding pocket; other site 983545000698 CRISPR-associated protein Cas9/Csn1, subtype II/NMEMI; Region: cas_Csn1; TIGR01865 983545000699 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 983545000700 active site 983545000701 PPOX class probable FMN-dependent enzyme, alr4036 family; Region: PPOX_FMN_cyano; TIGR04026 983545000702 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 983545000703 Uncharacterized conserved protein [Function unknown]; Region: COG2128 983545000704 tRNA-dihydrouridine synthase A; Provisional; Region: PRK11815 983545000705 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 983545000706 FMN binding site [chemical binding]; other site 983545000707 active site 983545000708 catalytic residues [active] 983545000709 substrate binding site [chemical binding]; other site 983545000710 Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647 983545000711 trimer interface [polypeptide binding]; other site 983545000712 active site 983545000713 substrate binding site [chemical binding]; other site 983545000714 CoA binding site [chemical binding]; other site 983545000715 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 983545000716 AMP-binding enzyme; Region: AMP-binding; cl15778 983545000717 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 983545000718 classical (c) SDRs; Region: SDR_c; cd05233 983545000719 NAD(P) binding site [chemical binding]; other site 983545000720 active site 983545000721 phage shock protein A; Region: phageshock_pspA; TIGR02977 983545000722 Protein of unknown function (DUF461); Region: DUF461; cl01071 983545000723 Uncharacterized protein conserved in bacteria (DUF2333); Region: DUF2333; cl11978 983545000724 sulfite reductase [NADPH] flavoprotein, alpha-component; Region: cysJ; TIGR01931 983545000725 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 983545000726 Cytochrome p450- like alpha subunits of E. coli sulfite reductase (SiR) multimerize with beta subunits to catalyze the NADPH dependent reduction of sulfite to sulfide. Beta subunits have an Fe4S4 cluster and a siroheme, while the alpha subunits (cysJ...; Region: SiR; cd06199 983545000727 FAD binding pocket [chemical binding]; other site 983545000728 FAD binding motif [chemical binding]; other site 983545000729 catalytic residues [active] 983545000730 NAD binding pocket [chemical binding]; other site 983545000731 phosphate binding motif [ion binding]; other site 983545000732 beta-alpha-beta structure motif; other site 983545000733 sulfite reductase subunit beta; Provisional; Region: PRK13504 983545000734 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 983545000735 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 983545000736 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 983545000737 Active Sites [active] 983545000738 Protein of unknown function (DUF2806); Region: DUF2806; cl12560 983545000739 Response regulator receiver domain; Region: Response_reg; pfam00072 983545000740 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl09944 983545000741 active site 983545000742 phosphorylation site [posttranslational modification] 983545000743 intermolecular recognition site; other site 983545000744 dimerization interface [polypeptide binding]; other site 983545000745 Domain of unknown function (DUF3369); Region: DUF3369; pfam11849 983545000746 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 983545000747 metal binding site [ion binding]; metal-binding site 983545000748 active site 983545000749 I-site; other site 983545000750 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 983545000751 Uncharacterized subfamily of Uracil-DNA glycosylases; Region: UDG_like_1; cd10033 983545000752 putative uracil binding site [chemical binding]; other site 983545000753 putative active site [active] 983545000754 The Delta9 Fatty Acid Desaturase (Delta9-FADS)-like CD includes the delta-9 and delta-11 acyl CoA desaturases found in various eukaryotes including vertebrates, insects, higher plants, and fungi. The delta-9 acyl-lipid desaturases are found in a wide...; Region: Delta9-FADS-like; cd03505 983545000755 Di-iron ligands [ion binding]; other site 983545000756 The Delta9 Fatty Acid Desaturase (Delta9-FADS)-like CD includes the delta-9 and delta-11 acyl CoA desaturases found in various eukaryotes including vertebrates, insects, higher plants, and fungi. The delta-9 acyl-lipid desaturases are found in a wide...; Region: Delta9-FADS-like; cd03505 983545000757 DNA-binding transcriptional repressor FabR; Provisional; Region: PRK11202 983545000758 Helix-turn-helix domains; Region: HTH; cl00088 983545000759 tRNA (uracil-5-)-methyltransferase; Region: trmA_only; TIGR02143 983545000760 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 983545000761 S-adenosylmethionine binding site [chemical binding]; other site 983545000762 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 983545000763 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 983545000764 active site 983545000765 phosphorylation site [posttranslational modification] 983545000766 intermolecular recognition site; other site 983545000767 dimerization interface [polypeptide binding]; other site 983545000768 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 983545000769 DNA binding residues [nucleotide binding] 983545000770 dimerization interface [polypeptide binding]; other site 983545000771 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 983545000772 S-adenosylmethionine binding site [chemical binding]; other site 983545000773 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 983545000774 S-adenosylmethionine binding site [chemical binding]; other site 983545000775 alanine racemase; Reviewed; Region: alr; PRK00053 983545000776 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, Proteobacterial Alanine Racemases; Region: PLPDE_III_AR_proteobact; cd06827 983545000777 active site 983545000778 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 983545000779 substrate binding site [chemical binding]; other site 983545000780 catalytic residues [active] 983545000781 dimer interface [polypeptide binding]; other site 983545000782 D-Alanine aminotransferase (D-AAT_like): D-amino acid aminotransferase catalyzes transamination between D-amino acids and their respective alpha-keto acids. It plays a major role in the synthesis of bacterial cell wall components like D-alanine and...; Region: D-AAT_like; cd01558 983545000783 homodimer interface [polypeptide binding]; other site 983545000784 substrate-cofactor binding pocket; other site 983545000785 pyridoxal 5'-phosphate binding site [chemical binding]; other site 983545000786 catalytic residue [active] 983545000787 Predicted RNA-bindining protein (contains S1 and HTH domains) [General function prediction only]; Region: COG2996 983545000788 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 983545000789 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 983545000790 OsmC-like protein; Region: OsmC; cl00767 983545000791 hypothetical protein; Provisional; Region: PRK05939 983545000792 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 983545000793 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 983545000794 catalytic residue [active] 983545000795 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: Unknown ABO13168; Region: LPLAT_ABO13168-like; cd07988 983545000796 putative acyl-acceptor binding pocket; other site 983545000797 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149 983545000798 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 983545000799 phosphopeptide binding site; other site 983545000800 NRDE protein; Region: NRDE; cl01315 983545000801 aromatic amino acid aminotransferase; Provisional; Region: PRK09257 983545000802 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 983545000803 pyridoxal 5'-phosphate binding site [chemical binding]; other site 983545000804 homodimer interface [polypeptide binding]; other site 983545000805 catalytic residue [active] 983545000806 RRM (RNA recognition motif), also known as RBD (RNA binding domain) or RNP (ribonucleoprotein domain), is a highly abundant domain in eukaryotes found in proteins involved in post-transcriptional gene expression processes including mRNA and rRNA...; Region: RRM; cd00590 983545000807 RNA/DNA binding site [nucleotide binding]; other site 983545000808 RRM dimerization site [polypeptide binding]; other site 983545000809 DNA-binding transcriptional regulator OxyR; Provisional; Region: PRK11151 983545000810 Helix-turn-helix domains; Region: HTH; cl00088 983545000811 The C-terminal substrate-binding domain of the LysR-type transcriptional regulator OxyR, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_OxyR; cd08411 983545000812 dimerization interface [polypeptide binding]; other site 983545000813 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeB; cd00884 983545000814 active site clefts [active] 983545000815 zinc binding site [ion binding]; other site 983545000816 dimer interface [polypeptide binding]; other site 983545000817 Sulfate transporter family; Region: Sulfate_transp; cl15842 983545000818 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 983545000819 Sulfate transporter family; Region: Sulfate_transp; cl15842 983545000820 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 983545000821 MatE; Region: MatE; cl10513 983545000822 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 983545000823 This family is most closely related to the GT1 family of glycosyltransferases. capH in Staphylococcus aureus has been shown to be required for the biosynthesis of the type 1 capsular polysaccharide (CP1); Region: GT1_CapH_like; cd03812 983545000824 putative ADP-binding pocket [chemical binding]; other site 983545000825 O-antigen polysaccharide polymerase Wzy; Region: O-ag_pol_Wzy; pfam14296 983545000826 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 983545000827 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 983545000828 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 983545000829 Bacterial sugar transferase; Region: Bac_transf; cl00939 983545000830 sugar O-acyltransferase, sialic acid O-acetyltransferase NeuD family; Region: NeuD_NnaD; TIGR03570 983545000831 Putative Acyltransferase (AT), Left-handed parallel beta-Helix (LbH) domain; This group is composed of mostly uncharacterized proteins containing an N-terminal helical subdomain followed by a LbH domain. The alignment contains 6 turns, each containing...; Region: LbH_AT_putative; cd03360 983545000832 putative trimer interface [polypeptide binding]; other site 983545000833 putative CoA binding site [chemical binding]; other site 983545000834 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 983545000835 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 983545000836 inhibitor-cofactor binding pocket; inhibition site 983545000837 pyridoxal 5'-phosphate binding site [chemical binding]; other site 983545000838 catalytic residue [active] 983545000839 Predicted nucleoside-diphosphate sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG1086 983545000840 UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237 983545000841 NAD(P) binding site [chemical binding]; other site 983545000842 homodimer interface [polypeptide binding]; other site 983545000843 substrate binding site [chemical binding]; other site 983545000844 active site 983545000845 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 983545000846 putative polysaccharide export protein, PEP-CTERM sytem-associated; Region: pepcterm_export; TIGR03027 983545000847 SLBB domain; Region: SLBB; pfam10531 983545000848 Uncharacterized protein involved in exopolysaccharide biosynthesis [Cell envelope biogenesis, outer membrane]; Region: GumC; COG3206 983545000849 Chain length determinant protein; Region: Wzz; cl15801 983545000850 Chain length determinant protein; Region: Wzz; cl15801 983545000851 capsular exopolysaccharide family; Region: eps_fam; TIGR01007 983545000852 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK00046 983545000853 FAD binding domain; Region: FAD_binding_4; pfam01565 983545000854 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 983545000855 bifunctional biotin--[acetyl-CoA-carboxylase] synthetase/biotin operon repressor; Provisional; Region: PRK11886 983545000856 Helix-turn-helix domains; Region: HTH; cl00088 983545000857 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 983545000858 Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237 983545000859 Type III pantothenate kinase; Region: Pan_kinase; cl09130 983545000860 elongation factor Tu; Reviewed; Region: PRK00049 983545000861 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 983545000862 G1 box; other site 983545000863 GEF interaction site [polypeptide binding]; other site 983545000864 GTP/Mg2+ binding site [chemical binding]; other site 983545000865 Switch I region; other site 983545000866 G2 box; other site 983545000867 G3 box; other site 983545000868 Switch II region; other site 983545000869 G4 box; other site 983545000870 G5 box; other site 983545000871 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 983545000872 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 983545000873 Antibiotic Binding Site [chemical binding]; other site 983545000874 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 983545000875 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 983545000876 substrate binding pocket [chemical binding]; other site 983545000877 membrane-bound complex binding site; other site 983545000878 hinge residues; other site 983545000879 Predicted oxidoreductases (related to aryl-alcohol dehydrogenases) [Energy production and conversion]; Region: Tas; COG0667 983545000880 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 983545000881 active site 983545000882 catalytic tetrad [active] 983545000883 Glutaryl-CoA dehydrogenase; Region: GCD; cd01151 983545000884 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 983545000885 FAD binding site [chemical binding]; other site 983545000886 substrate binding pocket [chemical binding]; other site 983545000887 catalytic base [active] 983545000888 PAS domain; Region: PAS_9; pfam13426 983545000889 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 983545000890 metal binding site [ion binding]; metal-binding site 983545000891 active site 983545000892 I-site; other site 983545000893 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 983545000894 Ras-related in brain (Rab) family of small guanosine triphosphatases (GTPases); Region: Rab; cd00154 983545000895 Rab subfamily motif 1 (RabSF1); other site 983545000896 G1 box; other site 983545000897 GTP/Mg2+ binding site [chemical binding]; other site 983545000898 Rab subfamily motif 2 (RabSF2); other site 983545000899 Switch I region; other site 983545000900 G2 box; other site 983545000901 effector interaction site; other site 983545000902 GDI interaction site; other site 983545000903 Rab family motif 1 (RabF1); other site 983545000904 GEF interaction site [polypeptide binding]; other site 983545000905 Rab family motif 2 (RabF2); other site 983545000906 G3 box; other site 983545000907 Switch II region; other site 983545000908 Rab family motif 3 (RabF3); other site 983545000909 Rab family motif 4 (RabF4); other site 983545000910 Rab family motif 5 (RabF5); other site 983545000911 Rab subfamily motif 3 (RabSF3); other site 983545000912 G4 box; other site 983545000913 G5 box; other site 983545000914 Rab subfamily motif 4 (RabSF4); other site 983545000915 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 983545000916 ligand binding site [chemical binding]; other site 983545000917 p-Aminobenzoyl-glutamate transporter family; Region: ydaH; TIGR00819 983545000918 C4-dicarboxylate anaerobic carrier; Region: DcuC; cl15356 983545000919 ferrochelatase; Reviewed; Region: hemH; PRK00035 983545000920 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 983545000921 C-terminal domain interface [polypeptide binding]; other site 983545000922 active site 983545000923 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 983545000924 active site 983545000925 N-terminal domain interface [polypeptide binding]; other site 983545000926 Domain of unknown function (DUF4112); Region: DUF4112; pfam13430 983545000927 Maltose-binding periplasmic proteins/domains [Carbohydrate transport and metabolism]; Region: MalE; COG2182 983545000928 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 983545000929 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 983545000930 GST_N family, Saccharomyces cerevisiae GTT2-like subfamily; composed of predominantly uncharacterized proteins with similarity to the S. cerevisiae GST protein, GTT2. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing...; Region: GST_N_GTT2_like; cd03051 983545000931 putative C-terminal domain interface [polypeptide binding]; other site 983545000932 putative GSH binding site (G-site) [chemical binding]; other site 983545000933 putative dimer interface [polypeptide binding]; other site 983545000934 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776 983545000935 N-terminal domain interface [polypeptide binding]; other site 983545000936 dimer interface [polypeptide binding]; other site 983545000937 substrate binding pocket (H-site) [chemical binding]; other site 983545000938 GSH-dependent disulfide bond oxidoreductase; Provisional; Region: PRK13972 983545000939 GST_N family, Ure2p-like subfamily; composed of the Saccharomyces cerevisiae Ure2p and related GSTs. Ure2p is a regulator for nitrogen catabolism in yeast. It represses the expression of several gene products involved in the use of poor nitrogen sources...; Region: GST_N_Ure2p_like; cd03048 983545000940 C-terminal domain interface [polypeptide binding]; other site 983545000941 GSH binding site (G-site) [chemical binding]; other site 983545000942 dimer interface [polypeptide binding]; other site 983545000943 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776 983545000944 N-terminal domain interface [polypeptide binding]; other site 983545000945 dimer interface [polypeptide binding]; other site 983545000946 substrate binding pocket (H-site) [chemical binding]; other site 983545000947 Domain of unknown function (DUF3859); Region: DUF3859; pfam12975 983545000948 FtsH protease regulator HflC; Provisional; Region: PRK11029 983545000949 Band_7_HflC: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfC (High frequency of lysogenization C). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflC; cd03405 983545000950 Bacterial membrane protein N terminal; Region: HflK_N; pfam12221 983545000951 Band_7_HflK: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfK (High frequency of lysogenization K). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflK; cd03404 983545000952 HflK protein; Region: hflK; TIGR01933 983545000953 GTPase HflX; Provisional; Region: PRK11058 983545000954 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 983545000955 HflX GTPase family; Region: HflX; cd01878 983545000956 G1 box; other site 983545000957 GTP/Mg2+ binding site [chemical binding]; other site 983545000958 Switch I region; other site 983545000959 G2 box; other site 983545000960 G3 box; other site 983545000961 Switch II region; other site 983545000962 G4 box; other site 983545000963 G5 box; other site 983545000964 Hfq, an abundant, ubiquitous RNA-binding protein, functions as a pleiotrophic regulator of RNA metabolism in prokaryotes, required for transcription of some transcripts and degradation of others. Hfq binds small RNA molecules called riboregulators that...; Region: Hfq; cd01716 983545000965 Sm1 motif; other site 983545000966 intra - hexamer interaction site; other site 983545000967 inter - hexamer interaction site [polypeptide binding]; other site 983545000968 nucleotide binding pocket [chemical binding]; other site 983545000969 Sm2 motif; other site 983545000970 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 983545000971 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 983545000972 DNA mismatch repair protein MutL; Region: mutl; TIGR00585 983545000973 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 983545000974 ATP binding site [chemical binding]; other site 983545000975 Mg2+ binding site [ion binding]; other site 983545000976 G-X-G motif; other site 983545000977 MutL_Trans_MutL: transducer domain, having a ribosomal S5 domain 2-like fold, found in proteins similar to Escherichia coli MutL. EcMutL belongs to the DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second...; Region: MutL_Trans_MutL; cd03482 983545000978 ATP binding site [chemical binding]; other site 983545000979 MutL C terminal dimerisation domain; Region: MutL_C; cl07336 983545000980 AMIN domain; Region: AMIN; pfam11741 983545000981 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 983545000982 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 983545000983 active site 983545000984 metal binding site [ion binding]; metal-binding site 983545000985 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118 983545000986 putative peptidoglycan binding site; other site 983545000987 Uncharacterized P-loop hydrolase UPF0079; Region: UPF0079; cl00520 983545000988 putative carbohydrate kinase; Provisional; Region: PRK10565 983545000989 YjeF-related protein N-terminus; Region: YjeF_N; cl00318 983545000990 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 983545000991 putative substrate binding site [chemical binding]; other site 983545000992 putative ATP binding site [chemical binding]; other site 983545000993 Uncharacterized Fe-S protein [Energy production and conversion]; Region: COG1600 983545000994 Domain of unknown function (DUF1730); Region: DUF1730; pfam08331 983545000995 Predicted O-methyltransferase [General function prediction only]; Region: COG4123 983545000996 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 983545000997 S-adenosylmethionine binding site [chemical binding]; other site 983545000998 CC3(TIP30)-like, atypical (a) SDRs; Region: CC3_like_SDR_a; cd05250 983545000999 NAD binding site [chemical binding]; other site 983545001000 active site 983545001001 Dipeptidyl peptidase IV (DPP IV) N-terminal region; Region: DPPIV_N; pfam00930 983545001002 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 983545001003 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 983545001004 Protein of unknown function (DUF1696); Region: DUF1696; pfam08000 983545001005 Threonine dehydratase [Amino acid transport and metabolism]; Region: IlvA; COG1171 983545001006 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 983545001007 tetramer interface [polypeptide binding]; other site 983545001008 pyridoxal 5'-phosphate binding site [chemical binding]; other site 983545001009 catalytic residue [active] 983545001010 N-carbamoylputrescine amidohydrolase (CPA) (class 11 nitrilases); Region: CPA; cd07573 983545001011 N-carbamolyputrescine amidase; Region: PLN02747 983545001012 putative active site; other site 983545001013 catalytic triad [active] 983545001014 putative dimer interface [polypeptide binding]; other site 983545001015 Porphyromonas-type peptidyl-arginine deiminase; Region: PAD_porph; cl01113 983545001016 agmatine deiminase; Region: agmatine_aguA; TIGR03380 983545001017 Protein of unknown function (DUF3718); Region: DUF3718; pfam12514 983545001018 Protein of unknown function (DUF3300); Region: DUF3300; pfam11737 983545001019 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 983545001020 GTP cyclohydrolase II [Coenzyme metabolism]; Region: RibA; COG0807 983545001021 dimerization interface [polypeptide binding]; other site 983545001022 active site 983545001023 7TMR-DISM extracellular 2; Region: 7TMR-DISMED2; pfam07696 983545001024 7TM diverse intracellular signalling; Region: 7TMR-DISM_7TM; pfam07695 983545001025 PAS domain S-box; Region: sensory_box; TIGR00229 983545001026 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 983545001027 metal binding site [ion binding]; metal-binding site 983545001028 active site 983545001029 I-site; other site 983545001030 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 983545001031 Uncharacterized conserved protein [Function unknown]; Region: COG0397; cl00428 983545001032 Cytochrome c; Region: Cytochrom_C; cl11414 983545001033 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 983545001034 GST_N family, Saccharomyces cerevisiae GTT1-like subfamily; composed of predominantly uncharacterized proteins with similarity to the S. cerevisiae GST protein, GTT1, and the Schizosaccharomyces pombe GST-III. GSTs are cytosolic dimeric proteins involved...; Region: GST_N_GTT1_like; cd03046 983545001035 putative C-terminal domain interface [polypeptide binding]; other site 983545001036 putative GSH binding site (G-site) [chemical binding]; other site 983545001037 putative dimer interface [polypeptide binding]; other site 983545001038 C-terminal, alpha helical domain of GTT1-like Glutathione S-transferases; Region: GST_C_GTT1_like; cd03189 983545001039 putative N-terminal domain interface [polypeptide binding]; other site 983545001040 putative dimer interface [polypeptide binding]; other site 983545001041 putative substrate binding pocket (H-site) [chemical binding]; other site 983545001042 Met Repressor, MetJ. MetJ is a bacterial regulatory protein that uses S-adenosylmethionine (SAM) as a corepressor to regulate the production of Methionine. MetJ binds arrays of two to five adjacent copies of an eight base-pair 'metbox' sequence. MetJ...; Region: Met_repressor_MetJ; cd00490 983545001043 dimerization interface [polypeptide binding]; other site 983545001044 DNA binding site [nucleotide binding] 983545001045 corepressor binding sites; other site 983545001046 Methylenetetrahydrofolate reductase; Region: MTHFR; pfam02219 983545001047 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 983545001048 FAD binding site [chemical binding]; other site 983545001049 Virulence factor BrkB; Region: Virul_fac_BrkB; cl07918 983545001050 Protein of unknown function (DUF2959); Region: DUF2959; pfam11172 983545001051 proline iminopeptidase, Neisseria-type subfamily; Region: pro_imino_pep_1; TIGR01249 983545001052 Serine carboxypeptidase S28; Region: Peptidase_S28; cl15279 983545001053 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563 983545001054 putative active site [active] 983545001055 dimerization interface [polypeptide binding]; other site 983545001056 putative tRNAtyr binding site [nucleotide binding]; other site 983545001057 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 983545001058 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 983545001059 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 983545001060 Coenzyme A binding pocket [chemical binding]; other site 983545001061 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 983545001062 crotonobetaine/carnitine-CoA ligase; Provisional; Region: PRK06155 983545001063 AMP-binding enzyme; Region: AMP-binding; cl15778 983545001064 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 983545001065 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 983545001066 [2Fe-2S] cluster binding site [ion binding]; other site 983545001067 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 983545001068 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 983545001069 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 983545001070 Helix-turn-helix domains; Region: HTH; cl00088 983545001071 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 983545001072 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 983545001073 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 983545001074 Helix-turn-helix domains; Region: HTH; cl00088 983545001075 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; cl12078 983545001076 Uncharacterized conserved protein [Function unknown]; Region: COG2128 983545001077 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 983545001078 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 983545001079 putative substrate translocation pore; other site 983545001080 Major Facilitator Superfamily; Region: MFS_1; pfam07690 983545001081 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; cl12078 983545001082 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 983545001083 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 983545001084 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 983545001085 active site 983545001086 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 983545001087 active site 983545001088 enoyl-CoA hydratase; Provisional; Region: PRK09245 983545001089 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 983545001090 substrate binding site [chemical binding]; other site 983545001091 oxyanion hole (OAH) forming residues; other site 983545001092 trimer interface [polypeptide binding]; other site 983545001093 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 983545001094 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 983545001095 active site 983545001096 Transcriptional regulator [Transcription]; Region: LysR; COG0583 983545001097 Helix-turn-helix domains; Region: HTH; cl00088 983545001098 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 983545001099 dimerization interface [polypeptide binding]; other site 983545001100 indolepyruvate ferredoxin oxidoreductase; Validated; Region: PRK09193 983545001101 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 983545001102 dimer interface [polypeptide binding]; other site 983545001103 PYR/PP interface [polypeptide binding]; other site 983545001104 TPP binding site [chemical binding]; other site 983545001105 substrate binding site [chemical binding]; other site 983545001106 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 983545001107 TPP-binding site [chemical binding]; other site 983545001108 Pyruvate ferredoxin/flavodoxin oxidoreductase; Region: POR; cl00546 983545001109 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 983545001110 Ligand binding site [chemical binding]; other site 983545001111 Electron transfer flavoprotein domain; Region: ETF; pfam01012 983545001112 electron transfer flavoprotein subunit alpha; Provisional; Region: PLN00022 983545001113 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715 983545001114 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 983545001115 Transmembrane secretion effector; Region: MFS_3; pfam05977 983545001116 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 983545001117 putative substrate translocation pore; other site 983545001118 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 983545001119 Ligand Binding Site [chemical binding]; other site 983545001120 Hemerythrin (Hr) is a non-heme diiron oxygen transport protein found in four marine invertebrate phyla including priapulida, brachiopoda, sipunculida, and annelida, as well as in protozoa. Myohemerythrin (Mhr), a hemerythrin homolog, is found in the...; Region: Hemerythrin; cl15774 983545001121 2,3-dihydroxybiphenyl 1,2-dioxygenase; Region: 23dbph12diox; TIGR03213 983545001122 N-terminal domain of 2,3-dihydroxybiphenyl 1,2-dioxygenase (BphC, EC 1.13.11.39) 1 from Rhodococcus globerulus P6 (BphC1-RGP6) and similar proteins; Region: BphC1-RGP6_N_like; cd07252 983545001123 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 983545001124 active site 983545001125 metal binding site [ion binding]; metal-binding site 983545001126 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 983545001127 classical (c) SDRs; Region: SDR_c; cd05233 983545001128 NAD(P) binding site [chemical binding]; other site 983545001129 active site 983545001130 4Fe-4S single cluster domain; Region: Fer4_15; pfam13459 983545001131 Transcriptional regulator [Transcription]; Region: IclR; COG1414 983545001132 Helix-turn-helix domains; Region: HTH; cl00088 983545001133 Bacterial transcriptional regulator; Region: IclR; pfam01614 983545001134 lipid-transfer protein; Provisional; Region: PRK07855 983545001135 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 983545001136 active site 983545001137 Rubredoxin-like zinc ribbon domain (DUF35_N); Region: DUF35_N; pfam12172 983545001138 DUF35 OB-fold domain; Region: DUF35; pfam01796 983545001139 short chain dehydrogenase; Provisional; Region: PRK12828 983545001140 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 983545001141 NAD(P) binding site [chemical binding]; other site 983545001142 active site 983545001143 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 983545001144 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 983545001145 iron-sulfur cluster [ion binding]; other site 983545001146 [2Fe-2S] cluster binding site [ion binding]; other site 983545001147 C-terminal catalytic domain of the oxygenase alpha subunit of naphthalene 1,2-dioxygenase (NDO) and related aromatic ring hydroxylating dioxygenases; Region: RHO_alpha_C_NDO-like; cd08881 983545001148 beta subunit interface [polypeptide binding]; other site 983545001149 alpha subunit interface [polypeptide binding]; other site 983545001150 active site 983545001151 substrate binding site [chemical binding]; other site 983545001152 Fe binding site [ion binding]; other site 983545001153 Ring hydroxylating dioxygenase beta subunit. This subunit has a similar structure to NTF-2, Ketosteroid isomerase and scytalone dehydratase.The degradation of aromatic compounds by aerobic bacteria frequently begins with the dihydroxylation of the...; Region: ring_hydroxylating_dioxygenases_beta; cd00667 983545001154 inter-subunit interface; other site 983545001155 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 983545001156 putative substrate translocation pore; other site 983545001157 Major Facilitator Superfamily; Region: MFS_1; pfam07690 983545001158 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cl00159 983545001159 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 983545001160 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 983545001161 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 983545001162 Protein of unknown function (DUF2889); Region: DUF2889; pfam11136 983545001163 short chain dehydrogenase; Validated; Region: PRK08589 983545001164 classical (c) SDRs; Region: SDR_c; cd05233 983545001165 NAD(P) binding site [chemical binding]; other site 983545001166 active site 983545001167 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 983545001168 4-hydroxyphenylacetate degradation bifunctional isomerase/decarboxylase, C-terminal subunit; Region: HpaG-C-term; TIGR02303 983545001169 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 983545001170 3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK09260 983545001171 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 983545001172 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 983545001173 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 983545001174 acetyl-CoA acetyltransferases; Region: AcCoA-C-Actrans; TIGR01930 983545001175 dimer interface [polypeptide binding]; other site 983545001176 active site 983545001177 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 983545001178 putative beta-ketoacyl acyl carrier protein [ACP] reductase (BKR)-like, SDR; Region: BKR_like_SDR_like; cd05344 983545001179 putative NAD(P) binding site [chemical binding]; other site 983545001180 putative active site [active] 983545001181 Protein of unknown function (DUF1302); Region: DUF1302; pfam06980 983545001182 Protein of unknown function (DUF1329); Region: DUF1329; pfam07044 983545001183 Uncharacterized protein related to plant photosystem II stability/assembly factor [General function prediction only]; Region: COG4447 983545001184 Predicted exporters of the RND superfamily [General function prediction only]; Region: COG1033 983545001185 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 983545001186 active site 983545001187 metal binding site [ion binding]; metal-binding site 983545001188 enoyl-CoA hydratase; Provisional; Region: PRK06688 983545001189 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 983545001190 substrate binding site [chemical binding]; other site 983545001191 oxyanion hole (OAH) forming residues; other site 983545001192 trimer interface [polypeptide binding]; other site 983545001193 3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830 983545001194 classical (c) SDRs; Region: SDR_c; cd05233 983545001195 NAD(P) binding site [chemical binding]; other site 983545001196 active site 983545001197 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 983545001198 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 983545001199 NAD(P) binding site [chemical binding]; other site 983545001200 GTP cyclohydrolase I (GTP-CH-I) catalyzes the conversion of GTP into dihydroneopterin triphosphate. The enzyme product is the precursor of tetrahydrofolate in eubacteria, fungi, and plants and of the folate analogs in methanogenic bacteria. In...; Region: GTP_cyclohydro1; cd00642 983545001201 homodecamer interface [polypeptide binding]; other site 983545001202 GTP cyclohydrolase I; Provisional; Region: PLN03044 983545001203 active site 983545001204 putative catalytic site residues [active] 983545001205 zinc binding site [ion binding]; other site 983545001206 GTP-CH-I/GFRP interaction surface; other site 983545001207 Uncharacterized subgroup of the CYTH-like superfamily having an associated CHAD domain; Region: CYTH-like_Pase_CHAD; cd07756 983545001208 putative active site [active] 983545001209 putative metal binding residues [ion binding]; other site 983545001210 signature motif; other site 983545001211 putative triphosphate binding site [ion binding]; other site 983545001212 N-terminal domain of reverse transcriptase; Region: RVT_N; pfam13655 983545001213 RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651 983545001214 Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078 983545001215 putative active site [active] 983545001216 putative NTP binding site [chemical binding]; other site 983545001217 putative nucleic acid binding site [nucleotide binding]; other site 983545001218 Group II intron, maturase-specific domain; Region: GIIM; pfam08388 983545001219 TnsA endonuclease N terminal; Region: Tn7_Tnp_TnsA_N; cl07370 983545001220 Helix-turn-helix domains; Region: HTH; cl00088 983545001221 putative transposase OrfB; Reviewed; Region: PHA02517 983545001222 HTH-like domain; Region: HTH_21; pfam13276 983545001223 Integrase core domain; Region: rve; cl01316 983545001224 Integrase core domain; Region: rve_3; cl15866 983545001225 putative toxin-antitoxin system antitoxin component, TIGR02293 family; Region: TAS_TIGR02293 983545001226 Protein of unknown function (DUF2384); Region: DUF2384; pfam09722 983545001227 Plasmid replication region DNA-binding N-term; Region: KfrA_N; pfam11740 983545001228 Replication protein A, class 2b aminoacyl-tRNA synthetases, and related proteins with oligonucleotide/oligosaccharide (OB) fold; Region: RPA_2b-aaRSs_OBF_like; cl09930 983545001229 generic binding surface I; other site 983545001230 generic binding surface II; other site 983545001231 Domain of unknown function (DUF3596); Region: DUF3596; pfam12167 983545001232 Phage integrase, N-terminal SAM-like domain; Region: Phage_integr_N; cl12235 983545001233 Site-specific recombinase XerD [DNA replication, recombination, and repair]; Region: XerD; COG4974 983545001234 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 983545001235 DNA binding site [nucleotide binding] 983545001236 Int/Topo IB signature motif; other site 983545001237 active site 983545001238 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 983545001239 Predicted phosphatase [General function prediction only]; Region: PhoX; COG3211 983545001240 N-acyl-D-glucosamine 2-epimerase [Carbohydrate transport and metabolism]; Region: COG2942 983545001241 AGE domain; N-acyl-D-glucosamine 2-epimerase domain; Responsible for intermediate epimerization during biosynthesis of N-acetylneuraminic acid. Catalytic mechanism is believed to be via nucleotide elimination and readdition and is ATP modulated. AGE is...; Region: AGE; cd00249 983545001242 dimerization interface [polypeptide binding]; other site 983545001243 putative active cleft [active] 983545001244 alpha-glucosidase; Provisional; Region: PRK10137 983545001245 Mannosyl oligosaccharide glucosidase; Region: Glyco_hydro_63; pfam03200 983545001246 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 983545001247 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl00284 983545001248 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl00284 983545001249 Sodium:solute symporter family; Region: SSF; cl00456 983545001250 Putative glycerate kinase [Carbohydrate transport and metabolism]; Region: GckA; COG2379 983545001251 Domain of unknown function (DUF4147); Region: DUF4147; pfam13660 983545001252 MOFRL family; Region: MOFRL; pfam05161 983545001253 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 983545001254 Helix-turn-helix domains; Region: HTH; cl00088 983545001255 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 983545001256 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 983545001257 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 983545001258 Uncharacterized enzyme of heme biosynthesis [Coenzyme metabolism]; Region: HemY; COG3071 983545001259 HemY protein N-terminus; Region: HemY_N; pfam07219 983545001260 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 983545001261 TPR motif; other site 983545001262 binding surface 983545001263 putative uroporphyrinogen III C-methyltransferase; Provisional; Region: PRK10920 983545001264 uroporphyrinogen-III synthase; Reviewed; Region: hemD; PRK05928 983545001265 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 983545001266 active site 983545001267 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 983545001268 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cd00494 983545001269 domain interfaces; other site 983545001270 active site 983545001271 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 983545001272 Phospholipase/Carboxylesterase; Region: Abhydrolase_2; pfam02230 983545001273 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 983545001274 Frataxin is a nuclear-encoded mitochondrial protein implicated in Friedreich's ataxia (FRDA), an human autosomal recessive neurodegenerative disease; Frataxin is found in eukaryotes and in purple bacteria; lack of frataxin causes iron to accumulate in...; Region: Frataxin; cd00503 983545001275 putative iron binding site [ion binding]; other site 983545001276 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 983545001277 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 983545001278 catalytic site [active] 983545001279 G-X2-G-X-G-K; other site 983545001280 RNA polymerase Rpb6; Region: RNA_pol_Rpb6; cl14651 983545001281 bifunctional (p)ppGpp synthetase II/ guanosine-3',5'-bis pyrophosphate 3'-pyrophosphohydrolase; Provisional; Region: PRK11092 983545001282 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 983545001283 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 983545001284 synthetase active site [active] 983545001285 NTP binding site [chemical binding]; other site 983545001286 metal binding site [ion binding]; metal-binding site 983545001287 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 983545001288 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 983545001289 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 983545001290 homotrimer interaction site [polypeptide binding]; other site 983545001291 putative active site [active] 983545001292 tRNA guanosine-2'-O-methyltransferase; Provisional; Region: PRK11081 983545001293 SpoU rRNA Methylase family; Region: SpoU_methylase; cl00362 983545001294 SpoU, rRNA methylase, C-terminal; Region: SpoU_methylas_C; pfam12105 983545001295 Peroxiredoxin (PRX)-like 2 family; hypothetical proteins that show sequence similarity to PRXs. Members of this group contain a CXXC motif, similar to TRX. The second cysteine in the motif corresponds to the peroxidatic cysteine of PRX, however, these...; Region: PRX_like2; cd02970 983545001296 putative catalytic residues [active] 983545001297 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 983545001298 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 983545001299 generic binding surface II; other site 983545001300 ssDNA binding site; other site 983545001301 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 983545001302 ATP binding site [chemical binding]; other site 983545001303 putative Mg++ binding site [ion binding]; other site 983545001304 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 983545001305 nucleotide binding region [chemical binding]; other site 983545001306 ATP-binding site [chemical binding]; other site 983545001307 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 983545001308 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_16; cd07263 983545001309 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 983545001310 Peroxiredoxin (PRX) family, PRX5-like subfamily; members are similar to the human protein, PRX5, a homodimeric TRX peroxidase, widely expressed in tissues and found cellularly in mitochondria, peroxisomes and the cytosol. The cellular location of PRX5...; Region: PRX5_like; cd03013 983545001311 catalytic triad [active] 983545001312 dimer interface [polypeptide binding]; other site 983545001313 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 983545001314 This family of ATP-binding proteins belongs to a multisubunit transporter involved in drug resistance (BcrA and DrrA), nodulation, lipid transport, and lantibiotic immunity. In bacteria and archaea, these transporters usually include an ATP-binding...; Region: ABC_DR_subfamily_A; cd03230 983545001315 Walker A/P-loop; other site 983545001316 ATP binding site [chemical binding]; other site 983545001317 Q-loop/lid; other site 983545001318 ABC transporter signature motif; other site 983545001319 Walker B; other site 983545001320 D-loop; other site 983545001321 H-loop/switch region; other site 983545001322 ABC-2 type transporter; Region: ABC2_membrane; cl11417 983545001323 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 983545001324 Histidine kinase; Region: HisKA_3; pfam07730 983545001325 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 983545001326 ATP binding site [chemical binding]; other site 983545001327 Mg2+ binding site [ion binding]; other site 983545001328 G-X-G motif; other site 983545001329 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 983545001330 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 983545001331 active site 983545001332 phosphorylation site [posttranslational modification] 983545001333 intermolecular recognition site; other site 983545001334 dimerization interface [polypeptide binding]; other site 983545001335 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 983545001336 DNA binding residues [nucleotide binding] 983545001337 dimerization interface [polypeptide binding]; other site 983545001338 Peptidase family M48; Region: Peptidase_M48; cl12018 983545001339 Putative cyclase; Region: Cyclase; cl00814 983545001340 HI0933-like protein; Region: HI0933_like; pfam03486 983545001341 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 983545001342 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 983545001343 active site 983545001344 catalytic site [active] 983545001345 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 983545001346 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 983545001347 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; cl01155 983545001348 Protein of unknown function (DUF1499); Region: DUF1499; cl01841 983545001349 Sterol desaturase [Lipid metabolism]; Region: ERG3; COG3000 983545001350 Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; cl01132 983545001351 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 983545001352 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4136 983545001353 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 983545001354 Walker A/P-loop; other site 983545001355 ATP binding site [chemical binding]; other site 983545001356 Q-loop/lid; other site 983545001357 ABC transporter signature motif; other site 983545001358 Walker B; other site 983545001359 D-loop; other site 983545001360 H-loop/switch region; other site 983545001361 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4135 983545001362 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 983545001363 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 983545001364 ABC-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: COG4134 983545001365 Protein of unknown function, DUF547; Region: DUF547; pfam04784 983545001366 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 983545001367 mercuric reductase; Validated; Region: PRK06370 983545001368 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 983545001369 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 983545001370 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 983545001371 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 983545001372 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl00284 983545001373 sugar efflux transporter; Region: 2A0120; TIGR00899 983545001374 PAS domain S-box; Region: sensory_box; TIGR00229 983545001375 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 983545001376 putative active site [active] 983545001377 heme pocket [chemical binding]; other site 983545001378 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 983545001379 metal binding site [ion binding]; metal-binding site 983545001380 active site 983545001381 I-site; other site 983545001382 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 983545001383 DNA binding site [nucleotide binding] 983545001384 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 983545001385 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 983545001386 Protein export membrane protein; Region: SecD_SecF; cl14618 983545001387 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 983545001388 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 983545001389 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 983545001390 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 983545001391 PA_M28_1_2: Protease-associated (PA) domain, peptidase family M28, subfamily-1, subgroup 2. A subgroup of PA-domain containing proteins belonging to the peptidase family M28. Family M28 contains aminopeptidases and carboxypeptidases, and has co-catalytic...; Region: PA_M28_1_2; cd04821 983545001392 PA/protease or protease-like domain interface [polypeptide binding]; other site 983545001393 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 983545001394 metal binding site [ion binding]; metal-binding site 983545001395 DsrE/DsrF-like family; Region: DrsE; cl00672 983545001396 Uncharacterized ACR, YggU family COG1872; Region: DUF167; cl00811 983545001397 Glutathione synthase/Ribosomal protein S6 modification enzyme (glutaminyl transferase) [Coenzyme metabolism / Translation, ribosomal structure and biogenesis]; Region: RimK; COG0189 983545001398 ATP-grasp domain; Region: ATP-grasp_4; cl03087 983545001399 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 983545001400 Helix-turn-helix domains; Region: HTH; cl00088 983545001401 Tryptophan 2,3-dioxygenase; Region: Trp_dioxygenase; cl03994 983545001402 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 983545001403 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 983545001404 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 983545001405 catalytic residue [active] 983545001406 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 983545001407 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 983545001408 active site 983545001409 motif I; other site 983545001410 motif II; other site 983545001411 ferredoxin-NADP reductase; Provisional; Region: PRK10926 983545001412 Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron transfer between NADP(H) and electron carrier proteins such as ferredoxin and flavodoxin. Isoforms of these flavoproteins (i.e. having a non-covalently...; Region: FNR1; cd06195 983545001413 FAD binding pocket [chemical binding]; other site 983545001414 FAD binding motif [chemical binding]; other site 983545001415 phosphate binding motif [ion binding]; other site 983545001416 beta-alpha-beta structure motif; other site 983545001417 NAD binding pocket [chemical binding]; other site 983545001418 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl15754 983545001419 siroheme synthase; Provisional; Region: cysG; PRK10637 983545001420 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 983545001421 Sirohaem synthase dimerisation region; Region: CysG_dimeriser; pfam10414 983545001422 Precorrin-3B methylase [Coenzyme metabolism]; Region: CobJ; cl00304 983545001423 ATP-dependent RNA helicase DeaD; Provisional; Region: PRK11634 983545001424 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 983545001425 ATP binding site [chemical binding]; other site 983545001426 Mg++ binding site [ion binding]; other site 983545001427 motif III; other site 983545001428 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 983545001429 nucleotide binding region [chemical binding]; other site 983545001430 ATP-binding site [chemical binding]; other site 983545001431 DbpA RNA binding domain; Region: DbpA; pfam03880 983545001432 putative PEP-CTERM system TPR-repeat lipoprotein; Region: PEP_TPR_lipo; TIGR02917 983545001433 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 983545001434 binding surface 983545001435 TPR motif; other site 983545001436 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 983545001437 TPR motif; other site 983545001438 binding surface 983545001439 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 983545001440 TPR motif; other site 983545001441 binding surface 983545001442 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 983545001443 TPR motif; other site 983545001444 binding surface 983545001445 thioredoxin 2; Provisional; Region: PRK10996 983545001446 Ribosomal protein S27; Region: Ribosomal_S27e; cl00897 983545001447 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 983545001448 catalytic residues [active] 983545001449 Ion transport protein; Region: Ion_trans; pfam00520 983545001450 Polycystin cation channel; Region: PKD_channel; pfam08016 983545001451 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 983545001452 5-hydroxyvalerate dehydrogenase (HVD) catalyzes the oxidation of 5-hydroxyvalerate to 5-oxovalerate with NAD+ as cofactor; Region: HVD; cd08193 983545001453 putative active site [active] 983545001454 metal binding site [ion binding]; metal-binding site 983545001455 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 983545001456 active site 983545001457 Class I hydroxymethylglutaryl-coenzyme A (HMG-CoA) reductase (HMGR); Region: HMG-CoA_reductase_classI; cd00643 983545001458 tetramerization interface [polypeptide binding]; other site 983545001459 substrate binding pocket [chemical binding]; other site 983545001460 catalytic residues [active] 983545001461 inhibitor binding sites; inhibition site 983545001462 NADP(H) binding site [chemical binding]; other site 983545001463 Ferredoxin [Energy production and conversion]; Region: COG1146 983545001464 4Fe-4S binding domain; Region: Fer4; cl02805 983545001465 Domain of unknown function (DUF3470); Region: DUF3470; pfam11953 983545001466 Uncharacterized FAD-dependent dehydrogenases [General function prediction only]; Region: COG2509 983545001467 outer membrane channel protein; Reviewed; Region: tolC; PRK09465 983545001468 ADP-ribose pyrophosphatase NudF; Provisional; Region: nudF; PRK10729 983545001469 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 983545001470 dimer interface [polypeptide binding]; other site 983545001471 ADP-ribose binding site [chemical binding]; other site 983545001472 active site 983545001473 nudix motif; other site 983545001474 metal binding site [ion binding]; metal-binding site 983545001475 Protein of unknown function (DUF1249); Region: DUF1249; cl01223 983545001476 Enterobacter aerogenes GpdQ and related proteins, metallophosphatase domain; Region: MPP_GpdQ; cd07402 983545001477 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 983545001478 active site 983545001479 metal binding site [ion binding]; metal-binding site 983545001480 hexamer interface [polypeptide binding]; other site 983545001481 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 983545001482 Uncharacterized protein family (UPF0227); Region: UPF0227; cl14886 983545001483 DNA topoisomerase IV subunit B; Reviewed; Region: PRK05559 983545001484 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 983545001485 ATP binding site [chemical binding]; other site 983545001486 Mg2+ binding site [ion binding]; other site 983545001487 G-X-G motif; other site 983545001488 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 983545001489 anchoring element; other site 983545001490 dimer interface [polypeptide binding]; other site 983545001491 ATP binding site [chemical binding]; other site 983545001492 Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718 983545001493 active site 983545001494 metal binding site [ion binding]; metal-binding site 983545001495 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 983545001496 Predicted periplasmic lipoprotein (DUF2279); Region: DUF2279; cl11574 983545001497 Small Multidrug Resistance protein; Region: Multi_Drug_Res; cl00910 983545001498 Lysine 2,3-aminomutase [Amino acid transport and metabolism]; Region: KamA; COG1509 983545001499 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 983545001500 FeS/SAM binding site; other site 983545001501 elongation factor P; Validated; Region: PRK00529 983545001502 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 983545001503 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 983545001504 RNA binding site [nucleotide binding]; other site 983545001505 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 983545001506 RNA binding site [nucleotide binding]; other site 983545001507 poxB regulator PoxA; Provisional; Region: PRK09350 983545001508 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it attaches...; Region: class_II_aaRS-like_core; cl00268 983545001509 motif 1; other site 983545001510 dimer interface [polypeptide binding]; other site 983545001511 active site 983545001512 motif 2; other site 983545001513 motif 3; other site 983545001514 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 983545001515 metal binding site [ion binding]; metal-binding site 983545001516 active site 983545001517 I-site; other site 983545001518 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 983545001519 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 983545001520 peptidyl-prolyl cis-trans isomerase B (rotamase B); Provisional; Region: PRK10791 983545001521 cyclophilin_EcCYP_like: cyclophilin-type A-like peptidylprolyl cis- trans isomerase (PPIase) domain similar to the cytosolic E. coli cyclophilin A and Streptomyces antibioticus SanCyp18. Compared to the archetypal cyclophilin Human cyclophilin A, these...; Region: cyclophilin_EcCYP_like; cd01920 983545001522 substrate binding site [chemical binding]; other site 983545001523 SAM-dependent 23S ribosomal RNA mG1835 methyltransferase; Provisional; Region: PRK15001 983545001524 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 983545001525 S-adenosylmethionine binding site [chemical binding]; other site 983545001526 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy; cl15773 983545001527 BolA-like protein; Region: BolA; cl00386 983545001528 Proteolipid membrane potential modulator; Region: Pmp3; cl00431 983545001529 trans-2-enoyl-CoA reductase; Provisional; Region: PRK13656 983545001530 NAD(P)H binding domain of trans-2-enoyl-CoA reductase; Region: Eno-Rase_NADH_b; pfam12242 983545001531 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 983545001532 Enoyl reductase FAD binding domain; Region: Eno-Rase_FAD_bd; pfam07055 983545001533 Na(+)-translocating NADH-quinone reductase subunit A; Provisional; Region: PRK05352 983545001534 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 983545001535 E3 interaction surface; other site 983545001536 lipoyl attachment site [posttranslational modification]; other site 983545001537 NQRA C-terminal domain; Region: NQRA_SLBB; pfam11973 983545001538 NQR2, RnfD, RnfE family; Region: NQR2_RnfD_RnfE; cl00779 983545001539 FMN-binding domain; Region: FMN_bind; cl01081 983545001540 Na+-transporting NADH:ubiquinone oxidoreductase, subunit NqrC [Energy production and conversion]; Region: NqrC; COG2869 983545001541 Rnf-Nqr subunit, membrane protein; Region: Rnf-Nqr; cl00597 983545001542 Rnf-Nqr subunit, membrane protein; Region: Rnf-Nqr; cl00597 983545001543 Na(+)-translocating NADH-quinone reductase subunit F; Provisional; Region: PRK05464 983545001544 Na+-translocating NADH:quinone oxidoreductase (Na+-NQR) FAD/NADH binding domain. (Na+-NQR) provides a means of storing redox reaction energy via the transmembrane translocation of Na2+ ions. The C-terminal domain resembles ferredoxin:NADP+ oxidoreductase; Region: NADH_quinone_reductase; cd06188 983545001545 FAD binding pocket [chemical binding]; other site 983545001546 FAD binding motif [chemical binding]; other site 983545001547 phosphate binding motif [ion binding]; other site 983545001548 beta-alpha-beta structure motif; other site 983545001549 NAD binding pocket [chemical binding]; other site 983545001550 ApbE family; Region: ApbE; cl00643 983545001551 Protein of unknown function (DUF539); Region: DUF539; cl01129 983545001552 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 983545001553 active site 983545001554 DNA polymerase IV; Validated; Region: PRK02406 983545001555 DNA binding site [nucleotide binding] 983545001556 Protein of unknown function (DUF1653); Region: DUF1653; cl01949 983545001557 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 983545001558 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574 983545001559 YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300 983545001560 active site 983545001561 elongation factor G; Reviewed; Region: PRK00007 983545001562 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 983545001563 G1 box; other site 983545001564 putative GEF interaction site [polypeptide binding]; other site 983545001565 GTP/Mg2+ binding site [chemical binding]; other site 983545001566 Switch I region; other site 983545001567 G2 box; other site 983545001568 G3 box; other site 983545001569 Switch II region; other site 983545001570 G4 box; other site 983545001571 G5 box; other site 983545001572 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 983545001573 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 983545001574 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 983545001575 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 983545001576 metal binding site [ion binding]; metal-binding site 983545001577 active site 983545001578 I-site; other site 983545001579 Periplasmic component of the Tol biopolymer transport system [Intracellular trafficking and secretion]; Region: TolB; COG0823 983545001580 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 983545001581 tol-pal system beta propeller repeat protein TolB; Region: propeller_TolB; TIGR02800 983545001582 Periplasmic component of the Tol biopolymer transport system [Intracellular trafficking and secretion]; Region: TolB; COG0823 983545001583 guanine deaminase; Provisional; Region: PRK09228 983545001584 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 983545001585 Amidohydrolase; Region: Amidohydro_4; pfam13147 983545001586 active site 983545001587 adenine deaminase; Region: ade; TIGR01178 983545001588 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 983545001589 GAF domain; Region: GAF; cl15785 983545001590 Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157 983545001591 general secretory pathway protein E; Region: type_II_gspE; TIGR02533 983545001592 PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129 983545001593 Walker A motif; other site 983545001594 ATP binding site [chemical binding]; other site 983545001595 Walker B motif; other site 983545001596 Ribosomal protein S10p/S20e; Region: Ribosomal_S10; cl00314 983545001597 Ribosomal protein L3; Region: Ribosomal_L3; cl00324 983545001598 Ribosomal protein L4/L1 family; Region: Ribosomal_L4; cl00325 983545001599 Ribosomal protein L23; Region: Ribosomal_L23; cl00326 983545001600 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 983545001601 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 983545001602 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 983545001603 Ribosomal protein S19; Region: Ribosomal_S19; cl00350 983545001604 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 983545001605 putative translocon binding site; other site 983545001606 protein-rRNA interface [nucleotide binding]; other site 983545001607 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 983545001608 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 983545001609 G-X-X-G motif; other site 983545001610 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 983545001611 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 983545001612 23S rRNA interface [nucleotide binding]; other site 983545001613 5S rRNA interface [nucleotide binding]; other site 983545001614 putative antibiotic binding site [chemical binding]; other site 983545001615 L25 interface [polypeptide binding]; other site 983545001616 L27 interface [polypeptide binding]; other site 983545001617 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 983545001618 23S rRNA interface [nucleotide binding]; other site 983545001619 putative translocon interaction site; other site 983545001620 signal recognition particle (SRP54) interaction site; other site 983545001621 L23 interface [polypeptide binding]; other site 983545001622 trigger factor interaction site; other site 983545001623 Ribosomal protein S17; Region: Ribosomal_S17; cl00351 983545001624 PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated; Region: PDZ; cd00136 983545001625 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 983545001626 Active site serine [active] 983545001627 Fibronectin type III-like domain; Region: Fn3-like; cl15273 983545001628 Fibronectin type III-like domain; Region: Fn3-like; cl15273 983545001629 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; cl01155 983545001630 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 983545001631 metal binding site [ion binding]; metal-binding site 983545001632 active site 983545001633 I-site; other site 983545001634 Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753 983545001635 Clade 3 of the heme-binding enzyme catalase; Region: catalase_clade_3; cd08156 983545001636 tetramer interface [polypeptide binding]; other site 983545001637 heme binding pocket [chemical binding]; other site 983545001638 NADPH binding site [chemical binding]; other site 983545001639 Paraquat-inducible protein A; Region: PqiA; pfam04403 983545001640 formyltetrahydrofolate deformylase; Reviewed; Region: purU; PRK06027 983545001641 N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875 983545001642 Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648 983545001643 putative active site [active] 983545001644 putative substrate binding site [chemical binding]; other site 983545001645 putative cosubstrate binding site; other site 983545001646 catalytic site [active] 983545001647 2'-5' RNA ligase; Provisional; Region: PRK15124 983545001648 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 983545001649 ATP-dependent RNA helicase HrpB; Provisional; Region: PRK11664 983545001650 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 983545001651 ATP binding site [chemical binding]; other site 983545001652 putative Mg++ binding site [ion binding]; other site 983545001653 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 983545001654 ATP-dependent helicase C-terminal; Region: HrpB_C; pfam08482 983545001655 penicillin-binding protein 1B; Region: PBP_1b; TIGR02071 983545001656 Transglycosylase; Region: Transgly; cl07896 983545001657 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 983545001658 Nitrogen regulatory protein P-II; Region: P-II; cl00412 983545001659 Nitrogen regulatory protein P-II; Region: P-II; smart00938 983545001660 Ammonium Transporter Family; Region: Ammonium_transp; cl03012 983545001661 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 983545001662 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 983545001663 active site 983545001664 phosphorylation site [posttranslational modification] 983545001665 intermolecular recognition site; other site 983545001666 dimerization interface [polypeptide binding]; other site 983545001667 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 983545001668 Predicted periplasmic ligand-binding sensor domain [Signal transduction mechanisms]; Region: COG3292 983545001669 Predicted periplasmic ligand-binding sensor domain [Signal transduction mechanisms]; Region: COG3292 983545001670 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 983545001671 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 983545001672 ATP binding site [chemical binding]; other site 983545001673 Mg2+ binding site [ion binding]; other site 983545001674 G-X-G motif; other site 983545001675 Dyp-type peroxidase family; Region: Dyp_perox; cl01067 983545001676 cyclase homology domain; Region: CHD; cd07302 983545001677 nucleotidyl binding site; other site 983545001678 metal binding site [ion binding]; metal-binding site 983545001679 dimer interface [polypeptide binding]; other site 983545001680 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062 983545001681 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 983545001682 inhibitor-cofactor binding pocket; inhibition site 983545001683 pyridoxal 5'-phosphate binding site [chemical binding]; other site 983545001684 catalytic residue [active] 983545001685 aspartate carbamoyltransferase; Provisional; Region: PRK08192 983545001686 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 983545001687 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 983545001688 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 983545001689 AAA domain; Region: AAA_18; pfam13238 983545001690 SGNH_hydrolase subfamily, FeeA, FeeB and similar esterases/lipases. FeeA and FeeB are part of a biosynthetic gene cluster and may participate in the biosynthesis of long-chain N-acyltyrosines by providing saturated and unsaturated fatty acids, which it...; Region: FeeA_FeeB_like; cd01836 983545001691 active site 983545001692 catalytic triad [active] 983545001693 oxyanion hole [active] 983545001694 Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which...; Region: ZnMc; cl00064 983545001695 active site 983545001696 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 983545001697 Helix-turn-helix domains; Region: HTH; cl00088 983545001698 LysE type translocator; Region: LysE; cl00565 983545001699 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; cl11587 983545001700 Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which...; Region: ZnMc; cl00064 983545001701 Ser-Thr-rich glycosyl-phosphatidyl-inositol-anchored membrane family; Region: GPI-anchored; pfam10342 983545001702 Protein of unknown function (DUF2982); Region: DUF2982; pfam11201 983545001703 7TMR-DISM extracellular 2; Region: 7TMR-DISMED2; pfam07696 983545001704 7TM diverse intracellular signalling; Region: 7TMR-DISM_7TM; pfam07695 983545001705 TMAO reductase sytem sensor TorS; Region: TMAO_torS; TIGR02956 983545001706 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 983545001707 dimer interface [polypeptide binding]; other site 983545001708 phosphorylation site [posttranslational modification] 983545001709 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 983545001710 ATP binding site [chemical binding]; other site 983545001711 Mg2+ binding site [ion binding]; other site 983545001712 G-X-G motif; other site 983545001713 Response regulator receiver domain; Region: Response_reg; pfam00072 983545001714 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 983545001715 active site 983545001716 phosphorylation site [posttranslational modification] 983545001717 intermolecular recognition site; other site 983545001718 dimerization interface [polypeptide binding]; other site 983545001719 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cl00086 983545001720 Glucose/sorbosone dehydrogenases [Carbohydrate transport and metabolism]; Region: COG2133 983545001721 DNA topoisomerase IV subunit A; Validated; Region: PRK05561 983545001722 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes in DNA...; Region: TOP4c; cd00187 983545001723 CAP-like domain; other site 983545001724 active site 983545001725 primary dimer interface [polypeptide binding]; other site 983545001726 Carboxylesterase family; Region: COesterase; pfam00135 983545001727 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 983545001728 substrate binding pocket [chemical binding]; other site 983545001729 catalytic triad [active] 983545001730 Peptidase M14 Succinylglutamate desuccinylase (ASTE)/aspartoacylase (ASPA)-like subfamily; subgroup includes Pseudomonas aeruginosa AotO; Region: M14_PaAOTO_like; cd06250 983545001731 Succinylglutamate desuccinylase / Aspartoacylase family; Region: AstE_AspA; pfam04952 983545001732 active site 983545001733 Zn binding site [ion binding]; other site 983545001734 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 983545001735 Helix-turn-helix domains; Region: HTH; cl00088 983545001736 putative peptidase; Provisional; Region: PRK11649 983545001737 Opacity-associated protein A LysM-like domain; Region: OapA; pfam04225 983545001738 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 983545001739 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 983545001740 active site 983545001741 HIGH motif; other site 983545001742 dimer interface [polypeptide binding]; other site 983545001743 KMSKS motif; other site 983545001744 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cl09940 983545001745 Protein of unknown function (DUF2721); Region: DUF2721; pfam11026 983545001746 CobD/Cbib protein; Region: CobD_Cbib; cl00561 983545001747 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 983545001748 acetyl-CoA synthetase; Provisional; Region: PRK00174 983545001749 Domain of unknown function (DUF3448); Region: DUF3448; pfam11930 983545001750 AMP-binding enzyme; Region: AMP-binding; cl15778 983545001751 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 983545001752 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 983545001753 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 983545001754 active site 983545001755 phosphorylation site [posttranslational modification] 983545001756 intermolecular recognition site; other site 983545001757 dimerization interface [polypeptide binding]; other site 983545001758 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 983545001759 DNA binding residues [nucleotide binding] 983545001760 dimerization interface [polypeptide binding]; other site 983545001761 Sodium:solute symporter family; Region: SSF; cl00456 983545001762 PAS fold; Region: PAS_7; pfam12860 983545001763 Signal transduction histidine kinase, glucose-6-phosphate specific [Signal transduction mechanisms]; Region: UhpB; COG3851 983545001764 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 983545001765 dimer interface [polypeptide binding]; other site 983545001766 phosphorylation site [posttranslational modification] 983545001767 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 983545001768 ATP binding site [chemical binding]; other site 983545001769 Mg2+ binding site [ion binding]; other site 983545001770 G-X-G motif; other site 983545001771 Response regulator receiver domain; Region: Response_reg; pfam00072 983545001772 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 983545001773 active site 983545001774 phosphorylation site [posttranslational modification] 983545001775 intermolecular recognition site; other site 983545001776 dimerization interface [polypeptide binding]; other site 983545001777 Domain of unknown function (DUF4212); Region: DUF4212; cl01781 983545001778 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 983545001779 Sodium:solute symporter family; Region: SSF; cl00456 983545001780 FIST N domain; Region: FIST; cl10701 983545001781 FIST C domain; Region: FIST_C; pfam10442 983545001782 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 983545001783 metal binding site [ion binding]; metal-binding site 983545001784 active site 983545001785 I-site; other site 983545001786 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 983545001787 Predicted signal-transduction protein containing cAMP-binding and CBS domains [Signal transduction mechanisms]; Region: COG2905 983545001788 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 983545001789 ligand binding site [chemical binding]; other site 983545001790 flexible hinge region; other site 983545001791 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with either the CAP_ED (cAMP receptor protein effector domain) family of transcription factors and the DUF294 domain or the PB1 (Phox and Bem1p) domain; Region: CBS_pair_CAP-ED_DUF294_PBI_assoc2; cd04800 983545001792 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 983545001793 metal binding triad; other site 983545001794 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 983545001795 active site 983545001796 substrate binding site [chemical binding]; other site 983545001797 catalytic site [active] 983545001798 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 983545001799 TPR motif; other site 983545001800 TPR repeat; Region: TPR_11; pfam13414 983545001801 binding surface 983545001802 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 983545001803 binding surface 983545001804 TPR motif; other site 983545001805 TPR repeat; Region: TPR_11; pfam13414 983545001806 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 983545001807 binding surface 983545001808 TPR motif; other site 983545001809 non-haem dioxygenase in morphine synthesis N-terminal; Region: DIOX_N; cl14733 983545001810 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy; cl15773 983545001811 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 983545001812 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 983545001813 Nucleoside recognition; Region: Gate; cl00486 983545001814 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 983545001815 Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage pathway; Region: UMPK; cd02023 983545001816 ATP-binding site [chemical binding]; other site 983545001817 Sugar specificity; other site 983545001818 Pyrimidine base specificity; other site 983545001819 ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; pfam12974 983545001820 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383 983545001821 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl00284 983545001822 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 983545001823 putative metal binding site [ion binding]; other site 983545001824 M14 family of metallocarboxypeptidases and related proteins; Region: Peptidase_M14_like; cl11393 983545001825 arginine repressor; Provisional; Region: PRK05066 983545001826 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 983545001827 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 983545001828 malate dehydrogenase; Provisional; Region: PRK05086 983545001829 Glyoxysomal and mitochondrial malate dehydrogenases; Region: MDH_glyoxysomal_mitochondrial; cd01337 983545001830 NAD binding site [chemical binding]; other site 983545001831 dimerization interface [polypeptide binding]; other site 983545001832 Substrate binding site [chemical binding]; other site 983545001833 Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277 983545001834 Protein of unknown function (DUF2937); Region: DUF2937; pfam11157 983545001835 EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to...; Region: EFh; cd00051 983545001836 Ca2+ binding site [ion binding]; other site 983545001837 Iron-sulphur cluster biosynthesis; Region: Fe-S_biosyn; cl00400 983545001838 CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cd00400 983545001839 Voltage gated chloride channel; Region: Voltage_CLC; pfam00654 983545001840 Cl- selectivity filter; other site 983545001841 Cl- binding residues [ion binding]; other site 983545001842 pore gating glutamate residue; other site 983545001843 dimer interface [polypeptide binding]; other site 983545001844 Uncharacterized protein family (UPF0093); Region: UPF0093; cl00863 983545001845 GTP cyclohydrolase I (GTP-CH-I) catalyzes the conversion of GTP into dihydroneopterin triphosphate. The enzyme product is the precursor of tetrahydrofolate in eubacteria, fungi, and plants and of the folate analogs in methanogenic bacteria. In...; Region: GTP_cyclohydro1; cd00642 983545001846 homodecamer interface [polypeptide binding]; other site 983545001847 GTP cyclohydrolase I; Provisional; Region: PLN03044 983545001848 active site 983545001849 putative catalytic site residues [active] 983545001850 zinc binding site [ion binding]; other site 983545001851 GTP-CH-I/GFRP interaction surface; other site 983545001852 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 983545001853 Transcriptional regulator; Region: Transcrip_reg; cl00361 983545001854 Predicted ATPase [General function prediction only]; Region: COG1485 983545001855 periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037 983545001856 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149 983545001857 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 983545001858 protein binding site [polypeptide binding]; other site 983545001859 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 983545001860 serine endoprotease; Provisional; Region: PRK10898 983545001861 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149 983545001862 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 983545001863 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 983545001864 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 983545001865 hinge; other site 983545001866 active site 983545001867 BolA-like protein; Region: BolA; cl00386 983545001868 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 983545001869 anti sigma factor interaction site; other site 983545001870 regulatory phosphorylation site [posttranslational modification]; other site 983545001871 Toluene tolerance, Ttg2; Region: Tol_Tol_Ttg2; cl01074 983545001872 mce related protein; Region: MCE; pfam02470 983545001873 Permease; Region: Permease; cl00510 983545001874 putative ABC transporter ATP-binding protein YrbF; Provisional; Region: PRK11831 983545001875 ABC (ATP-binding cassette) transport system involved in resistant to organic solvents; ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars, ions, peptides, and more complex...; Region: ABC_Org_Solvent_Resistant; cd03261 983545001876 Walker A/P-loop; other site 983545001877 ATP binding site [chemical binding]; other site 983545001878 Q-loop/lid; other site 983545001879 ABC transporter signature motif; other site 983545001880 Walker B; other site 983545001881 D-loop; other site 983545001882 H-loop/switch region; other site 983545001883 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 983545001884 putative calcium/sodium:proton antiporter; Provisional; Region: PRK10734 983545001885 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 983545001886 D-arabinose 5-phosphate isomerase; Provisional; Region: PRK10892 983545001887 KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014 983545001888 putative active site [active] 983545001889 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with KpsF/GutQ domains in the API [A5P (D-arabinose 5-phosphate) isomerase] protein. These APIs catalyze the conversion of the pentose pathway...; Region: CBS_pair_KpsF_GutQ_assoc; cd04604 983545001890 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 983545001891 Low specificity phosphatase (HAD superfamily) [General function prediction only]; Region: COG1778 983545001892 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3117; cl01200 983545001893 Lipopolysaccharide-assembly, LptC-related; Region: LptC; pfam06835 983545001894 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1934 983545001895 OstA-like protein; Region: OstA; cl00844 983545001896 ABC-type (unclassified) transport system, ATPase component [General function prediction only]; Region: YhbG; COG1137 983545001897 The ABC transporters belonging to the YhbG family are similar to members of the Mj1267_LivG family, which is involved in the transport of branched-chain amino acids. The genes yhbG and yhbN are located in a single operon and may function together in...; Region: ABC_YhbG; cd03218 983545001898 Walker A/P-loop; other site 983545001899 ATP binding site [chemical binding]; other site 983545001900 Q-loop/lid; other site 983545001901 ABC transporter signature motif; other site 983545001902 Walker B; other site 983545001903 D-loop; other site 983545001904 H-loop/switch region; other site 983545001905 RNA polymerase factor sigma-54; Reviewed; Region: PRK05932 983545001906 Sigma-54 factor, Activator interacting domain (AID); Region: Sigma54_AID; pfam00309 983545001907 Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963 983545001908 Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552 983545001909 RaiA ('ribosome-associated inhibitor A', also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal A site; Region: RaiA; cd00552 983545001910 30S subunit binding site; other site 983545001911 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 983545001912 active site 983545001913 phosphorylation site [posttranslational modification] 983545001914 P-loop ATPase protein family; Region: ATP_bind_2; cl15794 983545001915 Predicted P-loop-containing kinase [General function prediction only]; Region: COG1660 983545001916 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 983545001917 regulatory protein interface [polypeptide binding]; other site 983545001918 active site 983545001919 regulatory phosphorylation site [posttranslational modification]; other site 983545001920 Predicted transcriptional regulators [Transcription]; Region: COG1510 983545001921 Helix-turn-helix domains; Region: HTH; cl00088 983545001922 Lipocalin / cytosolic fatty-acid binding protein family; Region: Lipocalin; cl01150 983545001923 Uncharacterized Zn-ribbon-containing protein involved in phosphonate metabolism [Inorganic ion transport and metabolism]; Region: PhnA; COG2824 983545001924 PhnA Zinc-Ribbon; Region: PhnA_Zn_Ribbon; pfam08274 983545001925 PhnA protein; Region: PhnA; pfam03831 983545001926 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: Unknown ACT14924; Region: LPLAT_ACT14924-like; cd07986 983545001927 putative acyl-acceptor binding pocket; other site 983545001928 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 983545001929 Dihydroorotase (DHOase) catalyzes the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in the pyrimidine biosynthesis. In contrast to the large polyfunctional CAD proteins of higher organisms, this group of DHOases is...; Region: DHOase; cd01294 983545001930 active site 983545001931 substrate binding pocket [chemical binding]; other site 983545001932 dimer interface [polypeptide binding]; other site 983545001933 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 983545001934 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 983545001935 substrate binding pocket [chemical binding]; other site 983545001936 membrane-bound complex binding site; other site 983545001937 hinge residues; other site 983545001938 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 983545001939 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 983545001940 substrate binding pocket [chemical binding]; other site 983545001941 membrane-bound complex binding site; other site 983545001942 hinge residues; other site 983545001943 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 983545001944 substrate binding site [chemical binding]; other site 983545001945 oxyanion hole (OAH) forming residues; other site 983545001946 trimer interface [polypeptide binding]; other site 983545001947 ATP-dependent RNA helicase DbpA; Provisional; Region: PRK11776 983545001948 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 983545001949 ATP binding site [chemical binding]; other site 983545001950 Mg++ binding site [ion binding]; other site 983545001951 motif III; other site 983545001952 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 983545001953 nucleotide binding region [chemical binding]; other site 983545001954 ATP-binding site [chemical binding]; other site 983545001955 DbpA RNA binding domain; Region: DbpA; pfam03880 983545001956 PilZ domain; Region: PilZ; cl01260 983545001957 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 983545001958 Demethylmenaquinone methyltransferase; Region: Methyltransf_6; cl00480 983545001959 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 983545001960 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 983545001961 MsbA is an essential ABC transporter, closely related to eukaryotic MDR proteins. ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars, ions, peptides, and more complex organic...; Region: ABCC_MsbA; cd03251 983545001962 Walker A/P-loop; other site 983545001963 ATP binding site [chemical binding]; other site 983545001964 Q-loop/lid; other site 983545001965 ABC transporter signature motif; other site 983545001966 Walker B; other site 983545001967 D-loop; other site 983545001968 H-loop/switch region; other site 983545001969 SecE/Sec61-gamma subunits of protein translocation complex; Region: SecE; cl00481 983545001970 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 983545001971 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 983545001972 putative homodimer interface [polypeptide binding]; other site 983545001973 KOW motif; Region: KOW; cl00354 983545001974 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 983545001975 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 983545001976 23S rRNA interface [nucleotide binding]; other site 983545001977 L7/L12 interface [polypeptide binding]; other site 983545001978 putative thiostrepton binding site; other site 983545001979 L25 interface [polypeptide binding]; other site 983545001980 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 983545001981 mRNA/rRNA interface [nucleotide binding]; other site 983545001982 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 983545001983 23S rRNA interface [nucleotide binding]; other site 983545001984 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 983545001985 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 983545001986 core dimer interface [polypeptide binding]; other site 983545001987 peripheral dimer interface [polypeptide binding]; other site 983545001988 L10 interface [polypeptide binding]; other site 983545001989 L11 interface [polypeptide binding]; other site 983545001990 putative EF-Tu interaction site [polypeptide binding]; other site 983545001991 putative EF-G interaction site [polypeptide binding]; other site 983545001992 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl04593 983545001993 DNA-directed RNA polymerase subunit beta'; Provisional; Region: PRK00566 983545001994 RNA polymerase beta subunit; Region: RNA_pol_Rpb2_1; pfam04563 983545001995 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 983545001996 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl04593 983545001997 RPB11 interaction site [polypeptide binding]; other site 983545001998 RPB12 interaction site [polypeptide binding]; other site 983545001999 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 983545002000 RPB3 interaction site [polypeptide binding]; other site 983545002001 RPB1 interaction site [polypeptide binding]; other site 983545002002 RPB11 interaction site [polypeptide binding]; other site 983545002003 RPB10 interaction site [polypeptide binding]; other site 983545002004 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 983545002005 DNA-directed RNA polymerase, beta' subunit/160 kD subunit [Transcription]; Region: RpoC; COG0086 983545002006 RNA polymerase Rpb1, domain 2; Region: RNA_pol_Rpb1_2; cl11591 983545002007 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 983545002008 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 983545002009 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 983545002010 unknown domain/DNA-directed RNA polymerase subunit A'' fusion protein; Provisional; Region: PRK14897 983545002011 Rpb1 - Rpb6 interaction site [polypeptide binding]; other site 983545002012 bifunctional DNA-directed RNA polymerase subunit beta/beta'; Reviewed; Region: PRK09603 983545002013 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 983545002014 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 983545002015 DNA binding site [nucleotide binding] 983545002016 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 983545002017 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 983545002018 S17 interaction site [polypeptide binding]; other site 983545002019 S8 interaction site; other site 983545002020 16S rRNA interaction site [nucleotide binding]; other site 983545002021 streptomycin interaction site [chemical binding]; other site 983545002022 23S rRNA interaction site [nucleotide binding]; other site 983545002023 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 983545002024 Ribosomal protein S7p/S5e; Region: Ribosomal_S7; cl00313 983545002025 elongation factor G; Reviewed; Region: PRK00007 983545002026 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 983545002027 G1 box; other site 983545002028 putative GEF interaction site [polypeptide binding]; other site 983545002029 GTP/Mg2+ binding site [chemical binding]; other site 983545002030 Switch I region; other site 983545002031 G2 box; other site 983545002032 G3 box; other site 983545002033 Switch II region; other site 983545002034 G4 box; other site 983545002035 G5 box; other site 983545002036 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 983545002037 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 983545002038 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 983545002039 elongation factor Tu; Reviewed; Region: PRK00049 983545002040 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 983545002041 G1 box; other site 983545002042 GEF interaction site [polypeptide binding]; other site 983545002043 GTP/Mg2+ binding site [chemical binding]; other site 983545002044 Switch I region; other site 983545002045 G2 box; other site 983545002046 G3 box; other site 983545002047 Switch II region; other site 983545002048 G4 box; other site 983545002049 G5 box; other site 983545002050 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 983545002051 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 983545002052 Antibiotic Binding Site [chemical binding]; other site 983545002053 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 983545002054 dimerization interface [polypeptide binding]; other site 983545002055 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 983545002056 dimer interface [polypeptide binding]; other site 983545002057 putative CheW interface [polypeptide binding]; other site 983545002058 hypothetical protein; Provisional; Region: PRK11568 983545002059 Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205 983545002060 Phosphoenolpyruvate carboxylase; Region: PEPcase; cl14656 983545002061 Phosphoenolpyruvate carboxylase [Energy production and conversion]; Region: Ppc; COG2352 983545002062 Domain amino terminal to FKBP-type peptidyl-prolyl isomerase; Region: FKBP_N; pfam01346 983545002063 peptidyl-prolyl cis-trans isomerase; Provisional; Region: PRK11570 983545002064 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; cl11587 983545002065 Sulfate transporter family; Region: Sulfate_transp; cl15842 983545002066 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 983545002067 Sulfate transporter family; Region: Sulfate_transp; cl15842 983545002068 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 983545002069 Protein of unknown function (DUF3545); Region: DUF3545; pfam12065 983545002070 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 983545002071 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 983545002072 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 983545002073 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 983545002074 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 983545002075 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 983545002076 Uncharacterized protein family (UPF0149); Region: UPF0149; cl01173 983545002077 Protein of unknown function (DUF2750); Region: DUF2750; pfam11042 983545002078 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 983545002079 metal binding site [ion binding]; metal-binding site 983545002080 active site 983545002081 I-site; other site 983545002082 Cys/Met metabolism PLP-dependent enzyme; Region: Cys_Met_Meta_PP; pfam01053 983545002083 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 983545002084 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 983545002085 catalytic residue [active] 983545002086 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 983545002087 ATP binding site [chemical binding]; other site 983545002088 putative Mg++ binding site [ion binding]; other site 983545002089 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 983545002090 nucleotide binding region [chemical binding]; other site 983545002091 ATP-binding site [chemical binding]; other site 983545002092 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 983545002093 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 983545002094 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 983545002095 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 983545002096 Protein export membrane protein; Region: SecD_SecF; cl14618 983545002097 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 983545002098 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 983545002099 Protein of unknown function (DUF1244); Region: DUF1244; cl01385 983545002100 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 983545002101 CoenzymeA binding site [chemical binding]; other site 983545002102 subunit interaction site [polypeptide binding]; other site 983545002103 PHB binding site; other site 983545002104 Protein of unknown function, DUF; Region: DUF413; cl10479 983545002105 acetolactate synthase 3 catalytic subunit; Validated; Region: PRK06466 983545002106 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 983545002107 PYR/PP interface [polypeptide binding]; other site 983545002108 dimer interface [polypeptide binding]; other site 983545002109 TPP binding site [chemical binding]; other site 983545002110 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; cl00815 983545002111 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 983545002112 TPP-binding site [chemical binding]; other site 983545002113 dimer interface [polypeptide binding]; other site 983545002114 acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895 983545002115 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 983545002116 putative valine binding site [chemical binding]; other site 983545002117 dimer interface [polypeptide binding]; other site 983545002118 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 983545002119 thymidine kinase; Provisional; Region: PRK04296 983545002120 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 983545002121 metal binding site [ion binding]; metal-binding site 983545002122 active site 983545002123 I-site; other site 983545002124 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 983545002125 Transcriptional regulators [Transcription]; Region: FadR; COG2186 983545002126 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 983545002127 DNA-binding site [nucleotide binding]; DNA binding site 983545002128 FCD domain; Region: FCD; cl11656 983545002129 benzoate transporter; Region: benE; TIGR00843 983545002130 Benzoate membrane transport protein; Region: BenE; pfam03594 983545002131 Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385 983545002132 Membrane transport protein; Region: Mem_trans; cl09117 983545002133 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 983545002134 short chain dehydrogenase; Provisional; Region: PRK08251 983545002135 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 983545002136 NAD(P) binding site [chemical binding]; other site 983545002137 active site 983545002138 Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP; cd07040 983545002139 catalytic core [active] 983545002140 Predicted aminoglycoside phosphotransferase [General function prediction only]; Region: COG3173 983545002141 Acyl-CoA dehydrogenase (ACAD) 10 and 11, N-terminal domain, and similar proteins. This subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: ACAD10_11_like; cd05154 983545002142 putative active site [active] 983545002143 putative substrate binding site [chemical binding]; other site 983545002144 ATP binding site [chemical binding]; other site 983545002145 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 983545002146 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 983545002147 active site 983545002148 Transcriptional regulator [Transcription]; Region: LysR; COG0583 983545002149 Helix-turn-helix domains; Region: HTH; cl00088 983545002150 The C-terminal substrate binding domain of LysR-type transcriptional regulators that involved in the catabolism of nitroaromatic/naphthalene compounds and that of related regulators; contains the type 2 periplasmic binding fold; Region: PBP2_Nitroaromatics_like; cd08417 983545002151 substrate binding pocket [chemical binding]; other site 983545002152 dimerization interface [polypeptide binding]; other site 983545002153 Ammonium Transporter Family; Region: Ammonium_transp; cl03012 983545002154 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 983545002155 active site 983545002156 catalytic residues [active] 983545002157 Cadherin repeat-like domain; Region: CA_like; cl15786 983545002158 Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239 983545002159 MgtE intracellular N domain; Region: MgtE_N; cl15244 983545002160 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 983545002161 Divalent cation transporter; Region: MgtE; cl00786 983545002162 acylglycerophosphoethanolamine acyltransferase; Provisional; Region: PRK06814 983545002163 EamA-like transporter family; Region: EamA; cl01037 983545002164 galactokinase; Provisional; Region: PRK05101 983545002165 Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509 983545002166 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 983545002167 galactose-1-phosphate uridylyltransferase; Provisional; Region: PRK11720 983545002168 Galactose-1-phosphate uridyl transferase (GalT): This enzyme plays a key role in galactose metabolism by catalysing the transfer of a uridine 5'-phosphoryl group from UDP-galactose 1-phosphate. The structure of E.coli GalT reveals that the enzyme...; Region: GalT; cd00608 983545002169 dimer interface [polypeptide binding]; other site 983545002170 active site 983545002171 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 983545002172 N-succinylglutamate 5-semialdehyde dehydrogenase, AstD-like; Region: ALDH_SGSD_AstD; cd07095 983545002173 NAD(P) binding site [chemical binding]; other site 983545002174 catalytic residues [active] 983545002175 Arginine N-succinyltransferase beta subunit; Region: AstA; cl11440 983545002176 bifunctional N-succinyldiaminopimelate-aminotransferase/acetylornithine transaminase protein; Reviewed; Region: argD; PRK05093 983545002177 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 983545002178 inhibitor-cofactor binding pocket; inhibition site 983545002179 pyridoxal 5'-phosphate binding site [chemical binding]; other site 983545002180 catalytic residue [active] 983545002181 HDOD domain; Region: HDOD; pfam08668 983545002182 para-aminobenzoate synthase component II; Provisional; Region: PRK08857 983545002183 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 983545002184 glutamine binding [chemical binding]; other site 983545002185 catalytic triad [active] 983545002186 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 983545002187 Ligand binding site [chemical binding]; other site 983545002188 Electron transfer flavoprotein domain; Region: ETF; pfam01012 983545002189 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715 983545002190 electron transfer flavoprotein subunit alpha; Provisional; Region: PLN00022 983545002191 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 983545002192 acyl-CoA dehydrogenase; Provisional; Region: PTZ00456 983545002193 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 983545002194 active site 983545002195 Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806 983545002196 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 983545002197 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 983545002198 SurA N-terminal domain; Region: SurA_N_3; cl07813 983545002199 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 983545002200 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 983545002201 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 983545002202 active site 983545002203 HIGH motif; other site 983545002204 dimer interface [polypeptide binding]; other site 983545002205 KMSKS motif; other site 983545002206 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 983545002207 ribulose-phosphate 3-epimerase; Region: rpe; TIGR01163 983545002208 substrate binding site [chemical binding]; other site 983545002209 hexamer interface [polypeptide binding]; other site 983545002210 metal binding site [ion binding]; metal-binding site 983545002211 Bacterial protein of unknown function (Gcw_chp); Region: Gcw_chp; cl09901 983545002212 Protein of unknown function (DUF2970); Region: DUF2970; pfam11174 983545002213 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 983545002214 Uncharacterized protein conserved in bacteria [Function unknown]; Region: DamX; COG3266 983545002215 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 983545002216 active site 983545002217 dimer interface [polypeptide binding]; other site 983545002218 metal binding site [ion binding]; metal-binding site 983545002219 shikimate kinase; Reviewed; Region: aroK; PRK00131 983545002220 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 983545002221 ADP binding site [chemical binding]; other site 983545002222 magnesium binding site [ion binding]; other site 983545002223 putative shikimate binding site; other site 983545002224 type IV pilus secretin (or competence protein) PilQ; Region: IV_pilus_PilQ; TIGR02515 983545002225 Secretin and TonB N terminus short domain; Region: STN; cl06624 983545002226 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 983545002227 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 983545002228 Pilus assembly protein, PilP; Region: PilP; cl01235 983545002229 Pilus assembly protein, PilO; Region: PilO; cl01234 983545002230 Tfp pilus assembly protein PilN [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilN; COG3166 983545002231 Fimbrial assembly protein (PilN); Region: PilN; pfam05137 983545002232 Competence protein A; Region: Competence_A; pfam11104 983545002233 penicillin-binding protein 1a; Provisional; Region: mrcA; PRK11636 983545002234 Transglycosylase; Region: Transgly; cl07896 983545002235 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 983545002236 malate dehydrogenase; Provisional; Region: PRK13529 983545002237 Malic enzyme, N-terminal domain; Region: malic; pfam00390 983545002238 NAD(P) binding domain of malic enzyme (ME), subgroup 1; Region: NAD_bind_1_malic_enz; cd05312 983545002239 NAD(P) binding site [chemical binding]; other site 983545002240 PAS domain S-box; Region: sensory_box; TIGR00229 983545002241 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 983545002242 putative active site [active] 983545002243 heme pocket [chemical binding]; other site 983545002244 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080 983545002245 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 983545002246 ATP binding site [chemical binding]; other site 983545002247 Mg2+ binding site [ion binding]; other site 983545002248 G-X-G motif; other site 983545002249 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 983545002250 Helix-turn-helix domains; Region: HTH; cl00088 983545002251 AefR-like transcriptional repressor, C-terminal region; Region: TetR_C_7; pfam14246 983545002252 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 983545002253 The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915 983545002254 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 983545002255 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 983545002256 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 983545002257 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 983545002258 catalytic residues [active] 983545002259 OsmC-like protein; Region: OsmC; cl00767 983545002260 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 983545002261 Helix-turn-helix domains; Region: HTH; cl00088 983545002262 AefR-like transcriptional repressor, C-terminal region; Region: TetR_C_7; pfam14246 983545002263 Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566 983545002264 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 983545002265 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 983545002266 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 983545002267 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 983545002268 putative substrate translocation pore; other site 983545002269 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 983545002270 Peptide methionine sulfoxide reductase; Region: PMSR; cl00366 983545002271 carboxynorspermidine decarboxylase; Region: nspC; TIGR01047 983545002272 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Carboxynorspermidine Decarboxylase; Region: PLPDE_III_CANSDC; cd06829 983545002273 dimer interface [polypeptide binding]; other site 983545002274 active site 983545002275 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 983545002276 catalytic residues [active] 983545002277 substrate binding site [chemical binding]; other site 983545002278 Saccharopine dehydrogenase and related proteins [Amino acid transport and metabolism]; Region: LYS9; COG1748 983545002279 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 983545002280 Predicted membrane protein (DUF2061); Region: DUF2061; cl01257 983545002281 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 983545002282 AAA domain; Region: AAA_28; pfam13521 983545002283 Nicotinamide mononucleotide transporter; Region: NMN_transporter; cl01256 983545002284 Kelch motif; Region: Kelch_1; cl02701 983545002285 kelch-like protein; Provisional; Region: PHA03098 983545002286 Kelch motif; Region: Kelch_1; cl02701 983545002287 Kelch motif; Region: Kelch_1; cl02701 983545002288 1-aminocyclopropane-1-carboxylate deaminase [Amino acid transport and metabolism]; Region: Acd; COG2515 983545002289 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342 983545002290 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 983545002291 catalytic residue [active] 983545002292 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 983545002293 metal binding site [ion binding]; metal-binding site 983545002294 active site 983545002295 I-site; other site 983545002296 Predicted divalent heavy-metal cations transporter [Inorganic ion transport and metabolism]; Region: COG0428; cl00437 983545002297 MAPEG family; Region: MAPEG; cl09190 983545002298 Mechanosensitive ion channel; Region: MS_channel; pfam00924 983545002299 Isocitrate dehydrogenase kinase/phosphatase [Signal transduction mechanisms]; Region: COG4579 983545002300 Isocitrate dehydrogenase kinase/phosphatase (AceK); Region: AceK; cl01891 983545002301 RelA- and SpoT-like ppGpp Synthetases and Hydrolases, catalytic domain; Region: Rel-Spo_like; cl11966 983545002302 Predicted ATPase [General function prediction only]; Region: COG3899 983545002303 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 983545002304 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 983545002305 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 983545002306 DNA binding residues [nucleotide binding] 983545002307 dimerization interface [polypeptide binding]; other site 983545002308 Conserved TM helix; Region: TM_helix; pfam05552 983545002309 Mechanosensitive ion channel; Region: MS_channel; pfam00924 983545002310 Domain of unknown function (DUF4405); Region: DUF4405; pfam14358 983545002311 Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753 983545002312 Catalase-like heme-binding proteins and protein domains; Region: catalase_like; cl09506 983545002313 heme binding pocket [chemical binding]; other site 983545002314 Type 1 glutamine amidotransferase (GATase1)-like domain found in at the C-terminal of several large catalases; Region: GATase1_catalase; cd03132 983545002315 domain interactions; other site 983545002316 Mechanosensitive ion channel; Region: MS_channel; pfam00924 983545002317 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 983545002318 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl00284 983545002319 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 983545002320 binding surface 983545002321 TPR motif; other site 983545002322 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 983545002323 TPR motif; other site 983545002324 binding surface 983545002325 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 983545002326 binding surface 983545002327 TPR motif; other site 983545002328 Tetratricopeptide repeat; Region: TPR_16; pfam13432 983545002329 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 983545002330 TPR motif; other site 983545002331 binding surface 983545002332 Sulfotransferase family; Region: Sulfotransfer_3; cl14559 983545002333 Sulfotransferase family; Region: Sulfotransfer_2; pfam03567 983545002334 short chain dehydrogenase; Provisional; Region: PRK12937 983545002335 tetrahydroxynaphthalene/trihydroxynaphthalene reductase-like, classical (c) SDRs; Region: THN_reductase-like_SDR_c; cd05362 983545002336 NADP binding site [chemical binding]; other site 983545002337 homodimer interface [polypeptide binding]; other site 983545002338 active site 983545002339 substrate binding site [chemical binding]; other site 983545002340 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 983545002341 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441 983545002342 Tripartite ATP-independent periplasmic transporters, DctQ component; Region: DctQ; cl01181 983545002343 DctM-like transporters; Region: DctM; pfam06808 983545002344 C4-dicarboxylate anaerobic carrier; Region: DcuC; cl15356 983545002345 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 983545002346 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 983545002347 EamA-like transporter family; Region: EamA; cl01037 983545002348 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 983545002349 EamA-like transporter family; Region: EamA; cl01037 983545002350 Arsenate Reductase (ArsC) family, ArsC subfamily; arsenic reductases similar to that encoded by arsC on the R733 plasmid of Escherichia coli. E. coli ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], the first step in the...; Region: ArsC_ArsC; cd03034 983545002351 ArsC family; Region: ArsC; pfam03960 983545002352 catalytic residues [active] 983545002353 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 983545002354 Helix-turn-helix domains; Region: HTH; cl00088 983545002355 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 983545002356 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 983545002357 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 983545002358 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 983545002359 N-terminal plug; other site 983545002360 ligand-binding site [chemical binding]; other site 983545002361 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 983545002362 3-ketoacyl-(acyl-carrier-protein) reductase; Reviewed; Region: PRK12826 983545002363 NAD(P) binding site [chemical binding]; other site 983545002364 active site 983545002365 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 983545002366 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 983545002367 active site 983545002368 metal binding site [ion binding]; metal-binding site 983545002369 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 983545002370 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 983545002371 active site 983545002372 metal binding site [ion binding]; metal-binding site 983545002373 membrane-bound PQQ-dependent dehydrogenase, glucose/quinate/shikimate family; Region: PQQ_membr_DH; TIGR03074 983545002374 Membrane-bound PQQ-dependent glucose dehydrogenase; Region: PQQ_mGDH; cd10280 983545002375 Trp docking motif [polypeptide binding]; other site 983545002376 putative active site [active] 983545002377 DNA topoisomerase III; Provisional; Region: PRK07726 983545002378 TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362 983545002379 active site 983545002380 putative interdomain interaction site [polypeptide binding]; other site 983545002381 putative metal-binding site [ion binding]; other site 983545002382 putative nucleotide binding site [chemical binding]; other site 983545002383 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 983545002384 domain I; other site 983545002385 DNA binding groove [nucleotide binding] 983545002386 phosphate binding site [ion binding]; other site 983545002387 domain II; other site 983545002388 domain III; other site 983545002389 nucleotide binding site [chemical binding]; other site 983545002390 catalytic site [active] 983545002391 domain IV; other site 983545002392 PhoD-like phosphatase; Region: PhoD; pfam09423 983545002393 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 983545002394 active site 983545002395 metal binding site [ion binding]; metal-binding site 983545002396 Sodium:solute symporter family; Region: SSF; cl00456 983545002397 Mannitol-1-phosphate/altronate dehydrogenases [Carbohydrate transport and metabolism]; Region: MtlD; COG0246 983545002398 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 983545002399 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 983545002400 putative chaperone; Provisional; Region: PRK11678 983545002401 YHYH protein; Region: YHYH; pfam14240 983545002402 YHYH protein; Region: YHYH; pfam14240 983545002403 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 983545002404 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 983545002405 active site 983545002406 metal binding site [ion binding]; metal-binding site 983545002407 Secretin and TonB N terminus short domain; Region: STN; cl06624 983545002408 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 983545002409 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 983545002410 N-terminal plug; other site 983545002411 ligand-binding site [chemical binding]; other site 983545002412 Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712 983545002413 FecR protein; Region: FecR; pfam04773 983545002414 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 983545002415 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 983545002416 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 983545002417 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 983545002418 active site 983545002419 catalytic motif [active] 983545002420 Zn binding site [ion binding]; other site 983545002421 lipoprotein NlpI; Provisional; Region: PRK11189 983545002422 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 983545002423 binding surface 983545002424 TPR motif; other site 983545002425 Quinolinate synthetase A protein; Region: NadA; cl00420 983545002426 beta-phosphoglucomutase family hydrolase; Region: PGMB-YQAB-SF; TIGR02009 983545002427 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 983545002428 motif II; other site 983545002429 Helix-turn-helix domains; Region: HTH; cl00088 983545002430 WYL domain; Region: WYL; cl14852 983545002431 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_19; cd07262 983545002432 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 983545002433 Protein of unknown function VcgC/VcgE (DUF2780); Region: DUF2780; pfam11075 983545002434 Domain of Unknown Function (DUF748); Region: DUF748; pfam05359 983545002435 Domain of Unknown Function (DUF748); Region: DUF748; pfam05359 983545002436 Domain of Unknown Function (DUF748); Region: DUF748; pfam05359 983545002437 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cl02931 983545002438 ligand binding site [chemical binding]; other site 983545002439 TonB-dependent receptor; Region: TonB-Xanth-Caul; TIGR01782 983545002440 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl00284 983545002441 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl00284 983545002442 Periplasmic copper-binding protein (NosD); Region: NosD; pfam05048 983545002443 Alginate lyase; Region: Alginate_lyase2; pfam08787 983545002444 Predicted periplasmic ligand-binding sensor domain [Signal transduction mechanisms]; Region: COG3292 983545002445 Y_Y_Y domain; Region: Y_Y_Y; pfam07495 983545002446 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 983545002447 metal binding site [ion binding]; metal-binding site 983545002448 active site 983545002449 I-site; other site 983545002450 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 983545002451 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 983545002452 DNA-binding site [nucleotide binding]; DNA binding site 983545002453 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 983545002454 pyridoxal 5'-phosphate binding site [chemical binding]; other site 983545002455 homodimer interface [polypeptide binding]; other site 983545002456 catalytic residue [active] 983545002457 cytochrome c oxidase accessory protein FixG; Region: ccoG_rdxA_fixG; TIGR02745 983545002458 Ubp3 associated protein Bre5; Region: Bre5; pfam11614 983545002459 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 983545002460 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 983545002461 ATP binding site [chemical binding]; other site 983545002462 Mg2+ binding site [ion binding]; other site 983545002463 G-X-G motif; other site 983545002464 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 983545002465 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 983545002466 active site 983545002467 phosphorylation site [posttranslational modification] 983545002468 intermolecular recognition site; other site 983545002469 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 983545002470 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 983545002471 dimer interface [polypeptide binding]; other site 983545002472 phosphorylation site [posttranslational modification] 983545002473 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 983545002474 ATP binding site [chemical binding]; other site 983545002475 Mg2+ binding site [ion binding]; other site 983545002476 G-X-G motif; other site 983545002477 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 983545002478 active site 983545002479 phosphorylation site [posttranslational modification] 983545002480 intermolecular recognition site; other site 983545002481 dimerization interface [polypeptide binding]; other site 983545002482 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 983545002483 metal binding site [ion binding]; metal-binding site 983545002484 active site 983545002485 I-site; other site 983545002486 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 983545002487 Response regulator receiver domain; Region: Response_reg; pfam00072 983545002488 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 983545002489 active site 983545002490 phosphorylation site [posttranslational modification] 983545002491 intermolecular recognition site; other site 983545002492 dimerization interface [polypeptide binding]; other site 983545002493 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cl00086 983545002494 Response regulator receiver domain; Region: Response_reg; pfam00072 983545002495 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 983545002496 active site 983545002497 phosphorylation site [posttranslational modification] 983545002498 intermolecular recognition site; other site 983545002499 dimerization interface [polypeptide binding]; other site 983545002500 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 983545002501 metal binding site [ion binding]; metal-binding site 983545002502 active site 983545002503 I-site; other site 983545002504 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 983545002505 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 983545002506 metal binding site [ion binding]; metal-binding site 983545002507 active site 983545002508 I-site; other site 983545002509 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 983545002510 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 983545002511 Walker A motif; other site 983545002512 ATP binding site [chemical binding]; other site 983545002513 Walker B motif; other site 983545002514 arginine finger; other site 983545002515 Antibiotic biosynthesis monooxygenase; Region: ABM; cl10022 983545002516 Antibiotic biosynthesis monooxygenase; Region: ABM; cl10022 983545002517 Protein of unknown function (DUF2167); Region: DUF2167; cl01938 983545002518 Galactose mutarotase and related enzymes [Carbohydrate transport and metabolism]; Region: GalM; COG2017 983545002519 galactose mutarotase_like; Region: galactose_mutarotase_like; cd09019 983545002520 active site 983545002521 catalytic residues [active] 983545002522 glycerol kinase; Provisional; Region: glpK; PRK00047 983545002523 Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786 983545002524 N- and C-terminal domain interface [polypeptide binding]; other site 983545002525 active site 983545002526 MgATP binding site [chemical binding]; other site 983545002527 catalytic site [active] 983545002528 metal binding site [ion binding]; metal-binding site 983545002529 glycerol binding site [chemical binding]; other site 983545002530 homotetramer interface [polypeptide binding]; other site 983545002531 homodimer interface [polypeptide binding]; other site 983545002532 FBP binding site [chemical binding]; other site 983545002533 protein IIAGlc interface [polypeptide binding]; other site 983545002534 Transcriptional regulators [Transcription]; Region: FadR; COG2186 983545002535 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 983545002536 DNA-binding site [nucleotide binding]; DNA binding site 983545002537 FCD domain; Region: FCD; cl11656 983545002538 SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450 983545002539 2-keto-3-deoxy-galactonokinase [Carbohydrate transport and metabolism]; Region: DgoK; COG3734 983545002540 2-keto-3-deoxy-galactonokinase; Region: DGOK; pfam05035 983545002541 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 983545002542 classical (c) SDRs; Region: SDR_c; cd05233 983545002543 NAD(P) binding site [chemical binding]; other site 983545002544 active site 983545002545 cell division protein MraZ; Reviewed; Region: PRK00326 983545002546 MraZ protein; Region: MraZ; pfam02381 983545002547 MraZ protein; Region: MraZ; pfam02381 983545002548 Predicted S-adenosylmethionine-dependent methyltransferase involved in cell envelope biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG0275 983545002549 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 983545002550 Septum formation initiator; Region: DivIC; cl11433 983545002551 peptidoglycan synthase FtsI; Provisional; Region: PRK15105 983545002552 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 983545002553 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 983545002554 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 983545002555 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 983545002556 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 983545002557 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 983545002558 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase; Reviewed; Region: murF; PRK10773 983545002559 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 983545002560 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 983545002561 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 983545002562 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 983545002563 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 983545002564 Mg++ binding site [ion binding]; other site 983545002565 putative catalytic motif [active] 983545002566 putative substrate binding site [chemical binding]; other site 983545002567 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK03803 983545002568 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 983545002569 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 983545002570 Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511 983545002571 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 983545002572 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 983545002573 active site 983545002574 homodimer interface [polypeptide binding]; other site 983545002575 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 983545002576 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 983545002577 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 983545002578 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 983545002579 D-alanine--D-alanine ligase; Reviewed; Region: ddl; PRK01372 983545002580 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 983545002581 ATP-grasp domain; Region: ATP-grasp_4; cl03087 983545002582 Cell division septal protein [Cell envelope biogenesis, outer membrane]; Region: FtsQ; COG1589 983545002583 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 983545002584 Cell division protein FtsQ; Region: FtsQ; pfam03799 983545002585 cell division protein FtsA; Reviewed; Region: ftsA; PRK09472 983545002586 Cell division protein FtsA; Region: FtsA; cl11496 983545002587 Cell division protein FtsA; Region: FtsA; cl11496 983545002588 cell division protein FtsZ; Validated; Region: PRK09330 983545002589 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 983545002590 nucleotide binding site [chemical binding]; other site 983545002591 SulA interaction site; other site 983545002592 UDP-3-O-acyl-N-acetylglucosamine deacetylase [Cell envelope biogenesis, outer membrane]; Region: LpxC; cl00512 983545002593 UDP-3-O-acyl N-acetylglycosamine deacetylase; Region: LpxC; pfam03331 983545002594 Peptidase family M23; Region: Peptidase_M23; pfam01551 983545002595 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 983545002596 SecA preprotein cross-linking domain; Region: SecA_PP_bind; cl03078 983545002597 SEC-C motif; Region: SEC-C; pfam02810 983545002598 The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425 983545002599 active site 983545002600 8-oxo-dGMP binding site [chemical binding]; other site 983545002601 nudix motif; other site 983545002602 metal binding site [ion binding]; metal-binding site 983545002603 RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398 983545002604 tetramer (dimer of dimers) interface [polypeptide binding]; other site 983545002605 dimer interface [polypeptide binding]; other site 983545002606 active site 983545002607 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; cl00360 983545002608 NH_hydro_CaPnhB: A subgroup of nucleoside hydrolases similar to Corynebacterium ammoniagenes Purine/pyrimidine nucleoside hydrolase (pnhB). Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base. These...; Region: nuc_hydro_CaPnhB; cd02650 983545002609 active site 983545002610 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 983545002611 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 983545002612 substrate binding site [chemical binding]; other site 983545002613 dimer interface [polypeptide binding]; other site 983545002614 ATP binding site [chemical binding]; other site 983545002615 Uncharacterized protein family (UPF0149); Region: UPF0149; cl01173 983545002616 Aminopeptidase P, N-terminal domain; Region: AMP_N; cl08433 983545002617 proline aminopeptidase P II; Provisional; Region: PRK10879 983545002618 Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on...; Region: Prolidase; cd01087 983545002619 active site 983545002620 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 983545002621 Ubiquinone biosynthesis hydroxylase, UbiH/UbiF/VisC/COQ6 family; Region: Ubi-OHases; TIGR01988 983545002622 This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002 983545002623 putative deacylase active site [active] 983545002624 MarC family integral membrane protein; Region: MarC; cl00919 983545002625 Aerotolerance regulator N-terminal; Region: BatA; cl06567 983545002626 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 983545002627 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 983545002628 MoxR-like ATPases [General function prediction only]; Region: COG0714 983545002629 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 983545002630 Walker A motif; other site 983545002631 ATP binding site [chemical binding]; other site 983545002632 Walker B motif; other site 983545002633 arginine finger; other site 983545002634 Domain of unknown function (DUF4159); Region: DUF4159; pfam13709 983545002635 Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; cl00398 983545002636 Putative modulator of DNA gyrase; Region: PmbA_TldD; pfam01523 983545002637 Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; cl00398 983545002638 Putative modulator of DNA gyrase; Region: PmbA_TldD; pfam01523 983545002639 Bacterial protein of unknown function (DUF885); Region: DUF885; pfam05960 983545002640 nitrate reductase catalytic subunit; Provisional; Region: PRK13532 983545002641 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 983545002642 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 983545002643 A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cl00279 983545002644 active site 983545002645 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 983545002646 MerC mercury resistance protein; Region: MerC; cl03934 983545002647 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 983545002648 Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615 983545002649 active site 983545002650 catalytic site [active] 983545002651 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 983545002652 EamA-like transporter family; Region: EamA; cl01037 983545002653 EamA-like transporter family; Region: EamA; cl01037 983545002654 Phosphatidylserine decarboxylase; Region: PS_Dcarbxylase; cl03656 983545002655 GTPase RsgA; Reviewed; Region: PRK12288 983545002656 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 983545002657 RNA binding site [nucleotide binding]; other site 983545002658 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 983545002659 GTPase/Zn-binding domain interface [polypeptide binding]; other site 983545002660 GTP/Mg2+ binding site [chemical binding]; other site 983545002661 G4 box; other site 983545002662 G5 box; other site 983545002663 G1 box; other site 983545002664 Switch I region; other site 983545002665 G2 box; other site 983545002666 G3 box; other site 983545002667 Switch II region; other site 983545002668 DEDDh 3'-5' exonuclease domain of oligoribonuclease and similar proteins; Region: Orn; cd06135 983545002669 putative active site [active] 983545002670 putative substrate binding site [chemical binding]; other site 983545002671 catalytic site [active] 983545002672 dimer interface [polypeptide binding]; other site 983545002673 Formate/nitrite transporter; Region: Form_Nir_trans; cl00927 983545002674 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 983545002675 active site 983545002676 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 983545002677 Catalytic domain of Protein Kinases; Region: PKc; cd00180 983545002678 active site 983545002679 ATP binding site [chemical binding]; other site 983545002680 substrate binding site [chemical binding]; other site 983545002681 activation loop (A-loop); other site 983545002682 cyanate hydratase; Validated; Region: PRK02866 983545002683 Cyanase C-terminal domain. Cyanase (Cyanate lyase) is responsible for the hydrolysis of cyanate. It catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide. This allows organisms that possess the enzyme to overcome the...; Region: Cyanase_C; cd00559 983545002684 oligomer interface [polypeptide binding]; other site 983545002685 active site 983545002686 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 983545002687 PAS domain; Region: PAS_9; pfam13426 983545002688 putative active site [active] 983545002689 heme pocket [chemical binding]; other site 983545002690 PAS domain; Region: PAS_9; pfam13426 983545002691 Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain); Region: PAC; smart00086 983545002692 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 983545002693 dimer interface [polypeptide binding]; other site 983545002694 putative CheW interface [polypeptide binding]; other site 983545002695 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 983545002696 anaerobic nitric oxide reductase transcription regulator; Provisional; Region: PRK05022 983545002697 GAF domain; Region: GAF; cl15785 983545002698 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 983545002699 Walker A motif; other site 983545002700 ATP binding site [chemical binding]; other site 983545002701 Walker B motif; other site 983545002702 arginine finger; other site 983545002703 Helix-turn-helix domains; Region: HTH; cl00088 983545002704 bifunctional nitric oxide dioxygenase/dihydropteridine reductase 2; Provisional; Region: PRK13289 983545002705 Globins are heme proteins, which bind and transport oxygen. This family summarizes a diverse set of homologous protein domains, including: (1) tetrameric vertebrate hemoglobins, which are the major protein component of erythrocytes and transport oxygen...; Region: globin; cd01040 983545002706 heme-binding site [chemical binding]; other site 983545002707 FAD_NAD(P)H binding domain of flavohemoglobin. Flavohemoglobins have a globin domain containing a B-type heme fused with a ferredoxin reductase-like FAD/NAD-binding domain. Flavohemoglobins detoxify nitric oxide (NO) via an NO dioxygenase reaction. The...; Region: flavohem_like_fad_nad_binding; cd06184 983545002708 FAD binding pocket [chemical binding]; other site 983545002709 FAD binding motif [chemical binding]; other site 983545002710 phosphate binding motif [ion binding]; other site 983545002711 beta-alpha-beta structure motif; other site 983545002712 NAD binding pocket [chemical binding]; other site 983545002713 Heme binding pocket [chemical binding]; other site 983545002714 Glycosyl hydrolase family 3 C-terminal domain; Region: Glyco_hydro_3_C; pfam01915 983545002715 Fibronectin type III-like domain; Region: Fn3-like; cl15273 983545002716 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 983545002717 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 983545002718 RNA binding surface [nucleotide binding]; other site 983545002719 PseudoU_synth_RsuA: Pseudouridine synthase, Escherichia coli RsuA like. This group is comprised of eukaryotic and bacterial proteins similar to Escherichia coli RsuA. Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA...; Region: PseudoU_synth_RsuA; cd02553 983545002720 active site 983545002721 uracil binding [chemical binding]; other site 983545002722 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 983545002723 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 983545002724 dimerization interface [polypeptide binding]; other site 983545002725 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 983545002726 dimer interface [polypeptide binding]; other site 983545002727 putative CheW interface [polypeptide binding]; other site 983545002728 Protein of unknown function (DUF502); Region: DUF502; cl01107 983545002729 Bacterial protein of unknown function (DUF883); Region: DUF883; cl01888 983545002730 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; cl08040 983545002731 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019 983545002732 glutaredoxin 2; Provisional; Region: PRK10387 983545002733 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 983545002734 C-terminal, alpha helical domain of Glutaredoxin 2; Region: GST_C_GRX2; cd03199 983545002735 N-terminal domain interface [polypeptide binding]; other site 983545002736 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 983545002737 ATP binding site [chemical binding]; other site 983545002738 putative Mg++ binding site [ion binding]; other site 983545002739 acetylornithine aminotransferase; Provisional; Region: argD; PRK03244 983545002740 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 983545002741 nucleotide binding region [chemical binding]; other site 983545002742 ATP-binding site [chemical binding]; other site 983545002743 Double zinc ribbon; Region: DZR; pfam12773 983545002744 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 983545002745 D-galactonate transporter; Region: 2A0114; TIGR00893 983545002746 putative substrate translocation pore; other site 983545002747 exonuclease subunit SbcC; Provisional; Region: PRK10246 983545002748 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 983545002749 Walker A/P-loop; other site 983545002750 ATP binding site [chemical binding]; other site 983545002751 Q-loop/lid; other site 983545002752 exonuclease subunit SbcC; Provisional; Region: PRK10246 983545002753 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 983545002754 ABC transporter signature motif; other site 983545002755 Walker B; other site 983545002756 D-loop; other site 983545002757 H-loop/switch region; other site 983545002758 exonuclease subunit SbcD; Provisional; Region: PRK10966 983545002759 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 983545002760 active site 983545002761 metal binding site [ion binding]; metal-binding site 983545002762 DNA binding site [nucleotide binding] 983545002763 Type 5 capsule protein repressor C-terminal domain; Region: SbcD_C; pfam12320 983545002764 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 983545002765 N-terminal plug; other site 983545002766 ligand-binding site [chemical binding]; other site 983545002767 Protein of unknown function (DUF2797); Region: DUF2797; pfam10977 983545002768 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 983545002769 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 983545002770 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 983545002771 putative active site [active] 983545002772 heme pocket [chemical binding]; other site 983545002773 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 983545002774 metal binding site [ion binding]; metal-binding site 983545002775 active site 983545002776 I-site; other site 983545002777 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 983545002778 Fatty acyltransferase-like subfamily of the SGNH hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its...; Region: fatty_acyltransferase_like; cd01846 983545002779 active site 983545002780 catalytic triad [active] 983545002781 oxyanion hole [active] 983545002782 ABC transporter, permease/ATP-binding protein; Region: MsbA_rel; TIGR02204 983545002783 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 983545002784 MTABC3 (also known as ABCB6) is a mitochondrial ATP-binding cassette protein involved in iron homeostasis and one of four ABC transporters expressed in the mitochondrial inner membrane, the other three being MDL1(ABC7), MDL2, and ATM1. In fact, the...; Region: ABC_MTABC3_MDL1_MDL2; cd03249 983545002785 Walker A/P-loop; other site 983545002786 ATP binding site [chemical binding]; other site 983545002787 Q-loop/lid; other site 983545002788 ABC transporter signature motif; other site 983545002789 Walker B; other site 983545002790 D-loop; other site 983545002791 H-loop/switch region; other site 983545002792 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 983545002793 active site 983545002794 catalytic residues [active] 983545002795 metal binding site [ion binding]; metal-binding site 983545002796 Transglycosylase SLT domain; Region: SLT_2; pfam13406 983545002797 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic 'goose-type' lysozymes (GEWL). LTs catalyze...; Region: LT_GEWL; cd00254 983545002798 N-acetyl-D-glucosamine binding site [chemical binding]; other site 983545002799 catalytic residue [active] 983545002800 Putative peptidoglycan binding domain; Region: PG_binding_1; cl15437 983545002801 hypothetical protein; Provisional; Region: PRK01254 983545002802 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 983545002803 Domain of unknown function (DUF3362); Region: DUF3362; pfam11842 983545002804 A type 1 glutamine amidotransferase (GATase1)-like domain found in PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_like; cd03134 983545002805 intracellular protease, PfpI family; Region: PfpI; TIGR01382 983545002806 proposed catalytic triad [active] 983545002807 conserved cys residue [active] 983545002808 Gluconolactonase [Carbohydrate transport and metabolism]; Region: COG3386 983545002809 Strictosidine synthase; Region: Str_synth; pfam03088 983545002810 bifunctional aconitate hydratase 2/2-methylisocitrate dehydratase; Validated; Region: PRK09238 983545002811 Aconitase B swivel domain. Aconitate hydratase B is involved in energy metabolism as part of the TCA cycle. It catalyses the formation of cis-aconitate from citrate. This is the aconitase swivel domain, which undergoes swivelling conformational change in...; Region: AcnB_Swivel; cd01576 983545002812 substrate binding site [chemical binding]; other site 983545002813 Aconitate hydratase B catalyses the formation of cis-aconitate from citrate as part of the TCA cycle; Region: AcnB; cd01581 983545002814 substrate binding site [chemical binding]; other site 983545002815 ligand binding site [chemical binding]; other site 983545002816 Uncharacterized ACR, COG1430; Region: DUF192; cl00627 983545002817 amidase; Provisional; Region: PRK08137 983545002818 Amidase; Region: Amidase; cl11426 983545002819 aspartate kinase III; Validated; Region: PRK09084 983545002820 AAK_AKiii-LysC-EC: Amino Acid Kinase Superfamily (AAK), AKiii-LysC-EC: this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKIII. AKIII is a monofunctional class enzyme (LysC) found in some...; Region: AAK_AKiii-LysC-EC; cd04258 983545002821 nucleotide binding site [chemical binding]; other site 983545002822 putative catalytic residues [active] 983545002823 aspartate binding site [chemical binding]; other site 983545002824 ACT domains located C-terminal to the catalytic domain of the lysine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-LysC-EC_1; cd04932 983545002825 lysine allosteric regulatory site; other site 983545002826 dimer interface [polypeptide binding]; other site 983545002827 ACT domains located C-terminal to the catalytic domain of the lysine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-LysC-EC_2; cd04917 983545002828 dimer interface [polypeptide binding]; other site 983545002829 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 983545002830 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 983545002831 dimer interface [polypeptide binding]; other site 983545002832 putative CheW interface [polypeptide binding]; other site 983545002833 diadenosine tetraphosphatase; Reviewed; Region: apaH; PRK00166 983545002834 Escherichia coli ApaH and related proteins, metallophosphatase domain; Region: MPP_ApaH; cd07422 983545002835 active site 983545002836 metal binding site [ion binding]; metal-binding site 983545002837 Protein of unknown function (DUF525); Region: DUF525; cl01119 983545002838 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 983545002839 Pyridoxal phosphate biosynthetic protein PdxA; Region: PdxA; cl00873 983545002840 4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK03743 983545002841 peptidyl-prolyl cis-trans isomerase SurA; Provisional; Region: PRK10770 983545002842 SurA N-terminal domain; Region: SurA_N_3; cl07813 983545002843 PPIC-type PPIASE domain; Region: Rotamase; cl08278 983545002844 PPIC-type PPIASE domain; Region: Rotamase; cl08278 983545002845 OstA-like protein; Region: OstA; cl00844 983545002846 LPS assembly outer membrane complex protein LptD; Provisional; Region: PRK03761 983545002847 Organic solvent tolerance protein; Region: OstA_C; pfam04453 983545002848 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 983545002849 Phosphotransferase enzyme family; Region: APH; pfam01636 983545002850 NTP_transferase_like_1 is a member of the nucleotidyl transferase family; Region: NTP_transferase_like_1; cd06422 983545002851 Substrate binding site; other site 983545002852 metal-binding site 983545002853 Dna-J like membrane chaperone protein; Provisional; Region: djlA; PRK09430 983545002854 N-terminal tellurium resistance protein terB-like domain of heat shock DnaJ-like proteins; Region: terB_like_DjlA; cd07316 983545002855 putative metal binding site [ion binding]; other site 983545002856 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 983545002857 HSP70 interaction site [polypeptide binding]; other site 983545002858 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 983545002859 N-terminal plug; other site 983545002860 TonB-dependent hemoglobin/transferrin/lactoferrin receptor family protein; Region: TonB-hemlactrns; TIGR01786 983545002861 ligand-binding site [chemical binding]; other site 983545002862 Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182 983545002863 PepSY-associated TM helix; Region: PepSY_TM_2; cl15813 983545002864 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 983545002865 dimerization interface [polypeptide binding]; other site 983545002866 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 983545002867 dimer interface [polypeptide binding]; other site 983545002868 phosphorylation site [posttranslational modification] 983545002869 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 983545002870 ATP binding site [chemical binding]; other site 983545002871 Mg2+ binding site [ion binding]; other site 983545002872 G-X-G motif; other site 983545002873 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 983545002874 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 983545002875 active site 983545002876 phosphorylation site [posttranslational modification] 983545002877 intermolecular recognition site; other site 983545002878 dimerization interface [polypeptide binding]; other site 983545002879 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 983545002880 DNA binding site [nucleotide binding] 983545002881 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 983545002882 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl00284 983545002883 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl00284 983545002884 Type I phosphodiesterase / nucleotide pyrophosphatase; Region: Phosphodiest; pfam01663 983545002885 Predicted membrane protein (DUF2306); Region: DUF2306; cl02232 983545002886 O-acetylhomoserine aminocarboxypropyltransferase; Validated; Region: PRK06084 983545002887 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 983545002888 homodimer interface [polypeptide binding]; other site 983545002889 substrate-cofactor binding pocket; other site 983545002890 pyridoxal 5'-phosphate binding site [chemical binding]; other site 983545002891 catalytic residue [active] 983545002892 Protein of unknown function (DUF1439); Region: DUF1439; cl06345 983545002893 MltA-interacting protein MipA; Region: MipA; cl01504 983545002894 YcxB-like protein; Region: YcxB; pfam14317 983545002895 Mechanosensitive ion channel; Region: MS_channel; pfam00924 983545002896 putative uroporphyrinogen III C-methyltransferase; Provisional; Region: PRK10920 983545002897 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 983545002898 putative DNA binding site [nucleotide binding]; other site 983545002899 dimerization interface [polypeptide binding]; other site 983545002900 putative Zn2+ binding site [ion binding]; other site 983545002901 Low molecular weight phosphatase family; Region: LMWPc; cd00115 983545002902 Low molecular weight phosphotyrosine protein phosphatase; Region: LMWPc; pfam01451 983545002903 active site 983545002904 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 983545002905 Arsenite efflux pump ACR3 and related permeases [Inorganic ion transport and metabolism]; Region: ACR3; COG0798 983545002906 Membrane transport protein; Region: Mem_trans; cl09117 983545002907 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase; Region: DapD_actino; TIGR03535 983545002908 Putative 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (THP succinyltransferase), C-terminal left-handed parallel alpha-helix (LbH) domain: This group is composed of mostly uncharacterized proteins containing an N-terminal...; Region: LbH_THP_succinylT_putative; cd04649 983545002909 putative trimer interface [polypeptide binding]; other site 983545002910 putative CoA binding site [chemical binding]; other site 983545002911 RIO kinase family; RIO1, RIO3 and similar proteins, catalytic domain. The RIO kinase catalytic domain family is part of a larger superfamily, that includes the catalytic domains of other kinases such as the typical serine/threonine/tyrosine protein...; Region: RIO1_like; cd05145 983545002912 ATP binding site [chemical binding]; other site 983545002913 Bacterial aspartate proteases, retropepsin-like protease family; Region: retropepsin_like_bacteria; cd05483 983545002914 catalytic motif [active] 983545002915 Catalytic residue [active] 983545002916 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 983545002917 active site 983545002918 Domon-like ligand-binding domains; Region: DOMON_like; cl14783 983545002919 Domon-like ligand-binding domains; Region: DOMON_like; cl14783 983545002920 putative ligand binding site [chemical binding]; other site 983545002921 Protein of unknown function, DUF462; Region: DUF462; cl01190 983545002922 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; cl01255 983545002923 YfcL protein; Region: YfcL; pfam08891 983545002924 bifunctional tRNA (mnm(5)s(2)U34)-methyltransferase/FAD-dependent cmnm(5)s(2)U34 oxidoreductase; Reviewed; Region: mnmC; PRK01747 983545002925 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl15754 983545002926 3-oxoacyl-(acyl carrier protein) synthase I; Reviewed; Region: PRK07967 983545002927 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 983545002928 dimer interface [polypeptide binding]; other site 983545002929 active site 983545002930 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 983545002931 Fucose permease [Carbohydrate transport and metabolism]; Region: FucP; COG0738 983545002932 putative substrate translocation pore; other site 983545002933 23S rRNA methyltransferase A; Provisional; Region: rrmA; PRK11088 983545002934 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 983545002935 Domain of unknown function (DUF3413); Region: DUF3413; pfam11893 983545002936 Predicted hydrolase of alkaline phosphatase superfamily [General function prediction only]; Region: COG3083 983545002937 Protein of unknown function (DUF1414); Region: DUF1414; cl01175 983545002938 Nucleoid-associated protein [General function prediction only]; Region: COG3081 983545002939 37-kD nucleoid-associated bacterial protein; Region: NA37; cl15473 983545002940 Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1), 6-pyrovoyl...; Region: TFold; cl00263 983545002941 Peptidase family M23; Region: Peptidase_M23; pfam01551 983545002942 Ribosomal S4P (gammaproteobacterial); Region: Ribosomal_S4Pg; pfam11993 983545002943 Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618 983545002944 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 983545002945 metal binding site [ion binding]; metal-binding site 983545002946 active site 983545002947 I-site; other site 983545002948 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 983545002949 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 983545002950 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 983545002951 ligand binding site [chemical binding]; other site 983545002952 flexible hinge region; other site 983545002953 Helix-turn-helix domains; Region: HTH; cl00088 983545002954 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cl00214 983545002955 intersubunit interface [polypeptide binding]; other site 983545002956 active site 983545002957 Zn2+ binding site [ion binding]; other site 983545002958 hydrolase; Region: PLN02578 983545002959 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 983545002960 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 983545002961 erythronate-4-phosphate dehydrogenase; Validated; Region: PRK00257 983545002962 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 983545002963 Domain of unknown function (DUF3410); Region: DUF3410; pfam11890 983545002964 aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874 983545002965 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 983545002966 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; cl15856 983545002967 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cl00107 983545002968 FimV C-terminal domain; Region: FimV_Cterm; TIGR03504 983545002969 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 983545002970 dimerization interface [polypeptide binding]; other site 983545002971 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 983545002972 metal binding site [ion binding]; metal-binding site 983545002973 active site 983545002974 I-site; other site 983545002975 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 983545002976 Protein of unknown function, DUF481; Region: DUF481; cl01213 983545002977 Protein of unknown function, DUF481; Region: DUF481; cl01213 983545002978 HDOD domain; Region: HDOD; pfam08668 983545002979 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 983545002980 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 983545002981 Protein of unknown function (DUF1289); Region: DUF1289; cl01304 983545002982 Predicted metalloendopeptidase [Posttranslational modification, protein turnover, chaperones]; Region: PepO; COG3590 983545002983 Peptidase family M13 includes neprilysin, endothelin-converting enzyme I; Region: M13; cd08662 983545002984 active site 983545002985 Zn binding site [ion binding]; other site 983545002986 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06467 983545002987 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 983545002988 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 983545002989 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 983545002990 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 983545002991 E3 interaction surface; other site 983545002992 lipoyl attachment site [posttranslational modification]; other site 983545002993 dihydrolipoamide acetyltransferase; Reviewed; Region: PRK11855 983545002994 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 983545002995 E3 interaction surface; other site 983545002996 lipoyl attachment site [posttranslational modification]; other site 983545002997 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 983545002998 E3 interaction surface; other site 983545002999 lipoyl attachment site [posttranslational modification]; other site 983545003000 e3 binding domain; Region: E3_binding; pfam02817 983545003001 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; cl02008 983545003002 pyruvate dehydrogenase subunit E1; Reviewed; Region: aceE; PRK09405 983545003003 Thiamine pyrophosphate (TPP) family, E1 of E. coli PDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the Escherichia coli pyruvate dehydrogenase multienzyme complex (PDC). PDC catalyzes the oxidative...; Region: TPP_E1_EcPDC_like; cd02017 983545003004 dimer interface [polypeptide binding]; other site 983545003005 TPP-binding site [chemical binding]; other site 983545003006 transcriptional regulator PdhR; Reviewed; Region: pdhR; PRK09464 983545003007 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 983545003008 DNA-binding site [nucleotide binding]; DNA binding site 983545003009 FCD domain; Region: FCD; cl11656 983545003010 CobD/Cbib protein; Region: CobD_Cbib; cl00561 983545003011 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 983545003012 amidase catalytic site [active] 983545003013 Zn binding residues [ion binding]; other site 983545003014 substrate binding site [chemical binding]; other site 983545003015 Bacterial aspartate proteases, retropepsin-like protease family; Region: retropepsin_like_bacteria; cd05483 983545003016 catalytic motif [active] 983545003017 Catalytic residue [active] 983545003018 quinolinate phosphoribosyltransferase; Validated; Region: PRK09016 983545003019 Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572 983545003020 dimerization interface [polypeptide binding]; other site 983545003021 active site 983545003022 Tfp pilus assembly protein, major pilin PilA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilA; COG4969 983545003023 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; cl06830 983545003024 Pilin (bacterial filament); Region: Pilin; pfam00114 983545003025 Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459 983545003026 Type II secretion system (T2SS), protein F; Region: T2SF; cl00906 983545003027 Type II secretion system (T2SS), protein F; Region: T2SF; cl00906 983545003028 Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989 983545003029 Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750 983545003030 Type IV leader peptidase family; Region: Peptidase_A24; cl02077 983545003031 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 983545003032 CoA-binding site [chemical binding]; other site 983545003033 Protein of unknown function (DUF1342); Region: DUF1342; cl01892 983545003034 Domain of unknown function (DUF329); Region: DUF329; cl01144 983545003035 Peroxiredoxin (PRX) family, PRX5-like subfamily; members are similar to the human protein, PRX5, a homodimeric TRX peroxidase, widely expressed in tissues and found cellularly in mitochondria, peroxisomes and the cytosol. The cellular location of PRX5...; Region: PRX5_like; cd03013 983545003036 catalytic triad [active] 983545003037 dimer interface [polypeptide binding]; other site 983545003038 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 983545003039 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 983545003040 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 983545003041 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 983545003042 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776 983545003043 Osmosensitive K+ channel histidine kinase [Signal transduction mechanisms]; Region: KdpD; COG2205 983545003044 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080 983545003045 dimer interface [polypeptide binding]; other site 983545003046 phosphorylation site [posttranslational modification] 983545003047 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 983545003048 ATP binding site [chemical binding]; other site 983545003049 Mg2+ binding site [ion binding]; other site 983545003050 G-X-G motif; other site 983545003051 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1385; cl00611 983545003052 RNA methyltransferase; Region: Methyltrans_RNA; pfam04452 983545003053 Mechanosensitive ion channel; Region: MS_channel; pfam00924 983545003054 Peptidase family M48; Region: Peptidase_M48; cl12018 983545003055 S-adenosylmethionine synthetase; Validated; Region: PRK05250 983545003056 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 983545003057 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 983545003058 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 983545003059 transketolase; Reviewed; Region: PRK12753 983545003060 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 983545003061 TPP-binding site [chemical binding]; other site 983545003062 dimer interface [polypeptide binding]; other site 983545003063 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 983545003064 PYR/PP interface [polypeptide binding]; other site 983545003065 dimer interface [polypeptide binding]; other site 983545003066 TPP binding site [chemical binding]; other site 983545003067 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 983545003068 erythrose 4-phosphate dehydrogenase; Provisional; Region: PRK13535 983545003069 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 983545003070 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; cl15856 983545003071 Phosphoglycerate kinase; Region: PGK; pfam00162 983545003072 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 983545003073 substrate binding site [chemical binding]; other site 983545003074 hinge regions; other site 983545003075 ADP binding site [chemical binding]; other site 983545003076 catalytic site [active] 983545003077 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl09108 983545003078 catalytic residue [active] 983545003079 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 983545003080 Domain of unknown function (DUF4282); Region: DUF4282; pfam14110 983545003081 exopolyphosphatase; Provisional; Region: PRK10854 983545003082 Ppx/GppA phosphatase family; Region: Ppx-GppA; cl15449 983545003083 polyphosphate kinase 1; Region: poly_P_kin; TIGR03705 983545003084 Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089 983545003085 Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503 983545003086 Catalytic C-terminal domain, first repeat, of Escherichia coli polyphosphate kinase 1 and similar proteins; Region: PLDc_EcPPK1_C1_like; cd09164 983545003087 domain interface [polypeptide binding]; other site 983545003088 active site 983545003089 catalytic site [active] 983545003090 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 983545003091 putative active site [active] 983545003092 catalytic site [active] 983545003093 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 983545003094 Glycine cleavage system regulatory protein [Amino acid transport and metabolism]; Region: GcvR; COG2716 983545003095 ACT domains that comprise the Glycine Cleavage System Transcriptional Repressor (GcvR) protein, and other related domains; Region: ACT_GcvR_2; cd04869 983545003096 Protein of unknown function DUF47; Region: PhoU_div; pfam01865 983545003097 Phosphate transporter family; Region: PHO4; cl00396 983545003098 Phosphate transporter family; Region: PHO4; cl00396 983545003099 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 983545003100 Phosphate ATP-binding cassette transporter; Region: DUF3708; pfam12501 983545003101 phosphate ABC transporter, permease protein PstC; Region: phosphate_pstC; TIGR02138 983545003102 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 983545003103 dimer interface [polypeptide binding]; other site 983545003104 conserved gate region; other site 983545003105 putative PBP binding loops; other site 983545003106 ABC-ATPase subunit interface; other site 983545003107 Domain of unknown function (DUF3333); Region: DUF3333; pfam11812 983545003108 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 983545003109 dimer interface [polypeptide binding]; other site 983545003110 conserved gate region; other site 983545003111 putative PBP binding loops; other site 983545003112 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 983545003113 ABC-ATPase subunit interface; other site 983545003114 phosphate transporter ATP-binding protein; Provisional; Region: PRK14235 983545003115 Phosphate uptake is of fundamental importance in the cell physiology of bacteria because phosphate is required as a nutrient. The Pst system of E. coli comprises four distinct subunits encoded by the pstS, pstA, pstB, and pstC genes. The PstS protein...; Region: ABC_PstB_phosphate_transporter; cd03260 983545003116 Walker A/P-loop; other site 983545003117 ATP binding site [chemical binding]; other site 983545003118 Q-loop/lid; other site 983545003119 ABC transporter signature motif; other site 983545003120 Walker B; other site 983545003121 D-loop; other site 983545003122 H-loop/switch region; other site 983545003123 transcriptional regulator PhoU; Provisional; Region: PRK11115 983545003124 PhoU domain; Region: PhoU; pfam01895 983545003125 PhoU domain; Region: PhoU; pfam01895 983545003126 Phosphate-selective porin O and P; Region: Porin_O_P; cl01524 983545003127 Transcriptional regulator [Transcription]; Region: LysR; COG0583 983545003128 Helix-turn-helix domains; Region: HTH; cl00088 983545003129 The C-terminal substrate-binding domain of the LysR-type transcriptional regulator OxyR, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_OxyR; cd08411 983545003130 dimerization interface [polypeptide binding]; other site 983545003131 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 983545003132 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 983545003133 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 983545003134 DNA binding residues [nucleotide binding] 983545003135 V-type ATP synthase subunit I; Validated; Region: PRK05771 983545003136 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 983545003137 CoenzymeA binding site [chemical binding]; other site 983545003138 subunit interaction site [polypeptide binding]; other site 983545003139 PHB binding site; other site 983545003140 Platelet-activating factor acetylhydrolase, isoform II; Region: PAF-AH_p_II; pfam03403 983545003141 Predicted dienelactone hydrolase [General function prediction only]; Region: COG4188 983545003142 MgtC family; Region: MgtC; pfam02308 983545003143 biliverdin IX beta reductase (BVR-B, aka flavin reductase)-like proteins; atypical (a) SDRs; Region: BVR-B_like_SDR_a; cd05244 983545003144 NADH(P)-binding; Region: NAD_binding_10; pfam13460 983545003145 NAD binding site [chemical binding]; other site 983545003146 substrate binding site [chemical binding]; other site 983545003147 putative active site [active] 983545003148 Transcriptional regulator [Transcription]; Region: LysR; COG0583 983545003149 Helix-turn-helix domains; Region: HTH; cl00088 983545003150 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 983545003151 putative effector binding pocket; other site 983545003152 dimerization interface [polypeptide binding]; other site 983545003153 Fatty acid cis/trans isomerase (CTI); Region: CTI; pfam06934 983545003154 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 983545003155 putative substrate translocation pore; other site 983545003156 Major Facilitator Superfamily; Region: MFS_1; pfam07690 983545003157 sn-glycerol-3-phosphate transporter; Provisional; Region: glpT; PRK11273 983545003158 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 983545003159 putative substrate translocation pore; other site 983545003160 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK07515 983545003161 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 983545003162 dimer interface [polypeptide binding]; other site 983545003163 active site 983545003164 CoA binding pocket [chemical binding]; other site 983545003165 putative PEP-CTERM system histidine kinase; Region: PEP_his_kin; TIGR02916 983545003166 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 983545003167 ATP binding site [chemical binding]; other site 983545003168 Mg2+ binding site [ion binding]; other site 983545003169 G-X-G motif; other site 983545003170 PEP-CTERM-box response regulator transcription factor; Region: PEP_resp_reg; TIGR02915 983545003171 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 983545003172 active site 983545003173 phosphorylation site [posttranslational modification] 983545003174 intermolecular recognition site; other site 983545003175 dimerization interface [polypeptide binding]; other site 983545003176 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 983545003177 Walker A motif; other site 983545003178 ATP binding site [chemical binding]; other site 983545003179 Walker B motif; other site 983545003180 arginine finger; other site 983545003181 Helix-turn-helix domains; Region: HTH; cl00088 983545003182 LrgA family; Region: LrgA; cl00608 983545003183 LrgB-like family; Region: LrgB; cl00596 983545003184 Protein of unknown function (DUF1566); Region: DUF1566; pfam07603 983545003185 Protein of unknown function (DUF1566); Region: DUF1566; pfam07603 983545003186 Protein of unknown function (DUF2884); Region: DUF2884; cl08135 983545003187 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 983545003188 HemN family oxidoreductase; Provisional; Region: PRK05660 983545003189 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 983545003190 FeS/SAM binding site; other site 983545003191 HemN C-terminal domain; Region: HemN_C; pfam06969 983545003192 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 983545003193 active site 983545003194 dimerization interface [polypeptide binding]; other site 983545003195 Gram-negative bacterial tonB protein; Region: TonB; cl10048 983545003196 short chain dehydrogenase; Provisional; Region: PRK06197 983545003197 retinol dehydrogenase (retinol-DH), Light dependent Protochlorophyllide (Pchlide) OxidoReductase (LPOR) and related proteins, classical (c) SDRs; Region: retinol-DH_like_SDR_c_like; cd05327 983545003198 putative NAD(P) binding site [chemical binding]; other site 983545003199 active site 983545003200 Fibrobacter succinogenes major domain (Fib_succ_major); Region: Fib_succ_major; cl09821 983545003201 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 983545003202 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 983545003203 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 983545003204 DEAD-like helicases superfamily; Region: DEXDc; smart00487 983545003205 ATP binding site [chemical binding]; other site 983545003206 Mg++ binding site [ion binding]; other site 983545003207 motif III; other site 983545003208 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 983545003209 nucleotide binding region [chemical binding]; other site 983545003210 ATP-binding site [chemical binding]; other site 983545003211 dUTPase; Region: dUTPase_2; pfam08761 983545003212 dCTP pyrophosphatase; Provisional; Region: 56; PHA02602 983545003213 multifunctional tRNA nucleotidyl transferase/2'3'-cyclic phosphodiesterase/2'nucleotidase/phosphatase; Reviewed; Region: cca; PRK10885 983545003214 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 983545003215 active site 983545003216 NTP binding site [chemical binding]; other site 983545003217 metal binding triad [ion binding]; metal-binding site 983545003218 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 983545003219 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 983545003220 putative secretion ATPase, PEP-CTERM locus subfamily; Region: pepcterm_ATPase; TIGR03015 983545003221 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 983545003222 Walker A motif; other site 983545003223 ATP binding site [chemical binding]; other site 983545003224 Walker B motif; other site 983545003225 arginine finger; other site 983545003226 Domain of unknown function (DUF3391); Region: DUF3391; pfam11871 983545003227 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 983545003228 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 983545003229 substrate binding pocket [chemical binding]; other site 983545003230 membrane-bound complex binding site; other site 983545003231 hinge residues; other site 983545003232 TonB-dependent receptor; Region: TonB-Xanth-Caul; TIGR01782 983545003233 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl00284 983545003234 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl00284 983545003235 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl00284 983545003236 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 983545003237 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 983545003238 Na+/melibiose symporter and related transporters [Carbohydrate transport and metabolism]; Region: MelB; COG2211 983545003239 melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392 983545003240 melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392 983545003241 Cellobiose phosphorylase [Carbohydrate transport and metabolism]; Region: COG3459 983545003242 Putative carbohydrate binding domain; Region: CBM_X; cl05621 983545003243 Glycosyltransferase family 36; Region: Glyco_transf_36; pfam06165 983545003244 Glycosyltransferase 36 associated family; Region: GT36_AF; pfam06205 983545003245 Uncharacterized protein conserved in bacteria [Function unknown]; Region: CreA; COG3045 983545003246 CreA protein; Region: CreA; pfam05981 983545003247 Transcriptional regulators [Transcription]; Region: PurR; COG1609 983545003248 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 983545003249 DNA binding site [nucleotide binding] 983545003250 domain linker motif; other site 983545003251 Ligand-binding domain of an uncharacterized transcription regulator from Actinobacillus succinogenes and its close homologs from other bacteria; Region: PBP1_LacI_like_6; cd06284 983545003252 dimerization interface [polypeptide binding]; other site 983545003253 ligand binding site [chemical binding]; other site 983545003254 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 983545003255 substrate binding site [chemical binding]; other site 983545003256 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 983545003257 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 983545003258 substrate binding site [chemical binding]; other site 983545003259 ligand binding site [chemical binding]; other site 983545003260 tartrate dehydrogenase; Provisional; Region: PRK08194 983545003261 Isocitrate/isopropylmalate dehydrogenase; Region: Iso_dh; cl00445 983545003262 2-isopropylmalate synthase; Validated; Region: PRK00915 983545003263 2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940 983545003264 active site 983545003265 catalytic residues [active] 983545003266 metal binding site [ion binding]; metal-binding site 983545003267 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; cl07212 983545003268 enolase; Provisional; Region: eno; PRK00077 983545003269 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 983545003270 dimer interface [polypeptide binding]; other site 983545003271 metal binding site [ion binding]; metal-binding site 983545003272 substrate binding pocket [chemical binding]; other site 983545003273 CTP synthetase; Validated; Region: pyrG; PRK05380 983545003274 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 983545003275 Catalytic site [active] 983545003276 active site 983545003277 UTP binding site [chemical binding]; other site 983545003278 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 983545003279 active site 983545003280 putative oxyanion hole; other site 983545003281 catalytic triad [active] 983545003282 Response regulator receiver domain; Region: Response_reg; pfam00072 983545003283 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 983545003284 active site 983545003285 phosphorylation site [posttranslational modification] 983545003286 intermolecular recognition site; other site 983545003287 dimerization interface [polypeptide binding]; other site 983545003288 DNA mismatch repair protein MutS; Provisional; Region: PRK05399 983545003289 MutS domain I; Region: MutS_I; pfam01624 983545003290 MutS domain II; Region: MutS_II; pfam05188 983545003291 MutS family domain IV; Region: MutS_IV; pfam05190 983545003292 MutS1 homolog in eukaryotes. The MutS protein initiates DNA mismatch repair by recognizing mispaired and unpaired bases embedded in duplex DNA and activating endo- and exonucleases to remove the mismatch. Members of the MutS family possess C-terminal...; Region: ABC_MutS1; cd03284 983545003293 Walker A/P-loop; other site 983545003294 ATP binding site [chemical binding]; other site 983545003295 Q-loop/lid; other site 983545003296 ABC transporter signature motif; other site 983545003297 Walker B; other site 983545003298 D-loop; other site 983545003299 H-loop/switch region; other site 983545003300 Competence-damaged protein; Region: CinA; cl00666 983545003301 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy; cl15773 983545003302 Protein of unknown function (DUF3224); Region: DUF3224; pfam11528 983545003303 Glutathione-dependent formaldehyde-activating enzyme; Region: GFA; cl01553 983545003304 recombinase A; Provisional; Region: recA; PRK09354 983545003305 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 983545003306 hexamer interface [polypeptide binding]; other site 983545003307 Walker A motif; other site 983545003308 ATP binding site [chemical binding]; other site 983545003309 Walker B motif; other site 983545003310 JmjC domain, hydroxylase; Region: JmjC; cl15814 983545003311 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257; cl15822 983545003312 Flagellar hook-length control protein FliK; Region: Flg_hook; cl15269 983545003313 cytochrome c biogenesis protein CcmA; Provisional; Region: PRK13538 983545003314 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 983545003315 Walker A/P-loop; other site 983545003316 ATP binding site [chemical binding]; other site 983545003317 Q-loop/lid; other site 983545003318 ABC transporter signature motif; other site 983545003319 Walker B; other site 983545003320 D-loop; other site 983545003321 H-loop/switch region; other site 983545003322 CcmB protein; Region: CcmB; cl01016 983545003323 Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504 983545003324 Heme exporter protein D (CcmD); Region: CcmD; cl11475 983545003325 CcmE; Region: CcmE; cl00994 983545003326 Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504 983545003327 periplasmic protein thiol:disulfide oxidoreductases, DsbE subfamily; Region: dsbE; TIGR00385 983545003328 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 983545003329 Cytochrome C biogenesis protein; Region: CcmH; cl01179 983545003330 Cytochrome c biogenesis factor [Posttranslational modification, protein turnover, chaperones]; Region: COG4235 983545003331 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 983545003332 binding surface 983545003333 TPR motif; other site 983545003334 VacJ like lipoprotein; Region: VacJ; cl01073 983545003335 UDP-glucose 4-epimerase; Region: PLN02240 983545003336 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 983545003337 NAD binding site [chemical binding]; other site 983545003338 homodimer interface [polypeptide binding]; other site 983545003339 active site 983545003340 substrate binding site [chemical binding]; other site 983545003341 Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104 983545003342 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cl11420 983545003343 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 983545003344 polysaccharide export protein EpsE; Region: EpsE; TIGR03028 983545003345 SLBB domain; Region: SLBB; pfam10531 983545003346 SLBB domain; Region: SLBB; pfam10531 983545003347 SLBB domain; Region: SLBB; pfam10531 983545003348 Chain length determinant protein; Region: Wzz; cl15801 983545003349 Chain length determinant protein; Region: Wzz; cl15801 983545003350 UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237 983545003351 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 983545003352 NAD(P) binding site [chemical binding]; other site 983545003353 homodimer interface [polypeptide binding]; other site 983545003354 substrate binding site [chemical binding]; other site 983545003355 active site 983545003356 aminotransferase, LLPSF_NHT_00031 family; Region: NHT_00031; TIGR04181 983545003357 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 983545003358 inhibitor-cofactor binding pocket; inhibition site 983545003359 pyridoxal 5'-phosphate binding site [chemical binding]; other site 983545003360 catalytic residue [active] 983545003361 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 983545003362 active site 983545003363 N-acetylneuraminate synthase; Region: NeuB_NnaB; TIGR03569 983545003364 NeuB family; Region: NeuB; cl00496 983545003365 SAF domain; Region: SAF; cl00555 983545003366 CMP-NeuAc_Synthase activates N-acetylneuraminic acid by adding CMP moiety; Region: CMP-NeuAc_Synthase; cd02513 983545003367 ligand binding site; other site 983545003368 tetramer interface; other site 983545003369 FOG: CBS domain [General function prediction only]; Region: COG0517 983545003370 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 983545003371 NTP_trnasferase_like_2 is a member of the nucleotidyl transferase family; Region: NTP_transferase_like_2; cd06426 983545003372 Substrate binding site; other site 983545003373 metal-binding site 983545003374 Capsule polysaccharide biosynthesis protein; Region: Capsule_synth; pfam05159 983545003375 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 983545003376 active site 983545003377 MatE; Region: MatE; cl10513 983545003378 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 983545003379 active site 983545003380 undecaprenyl-phosphate alpha-N-acetylglucosaminyl 1-phosphate transferase; Provisional; Region: PRK15119 983545003381 This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853 983545003382 Mg++ binding site [ion binding]; other site 983545003383 putative catalytic motif [active] 983545003384 substrate binding site [chemical binding]; other site 983545003385 Bacterial putative lipoprotein (DUF940); Region: DUF940; pfam06082 983545003386 Capsule biosynthesis GfcC; Region: Caps_synth_GfcC; pfam06251 983545003387 Protein of unknown function (DUF2886); Region: DUF2886; pfam11102 983545003388 Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004 983545003389 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 983545003390 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 983545003391 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 983545003392 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 983545003393 active site 983545003394 tetramer interface; other site 983545003395 Helix-hairpin-helix motif; Region: HHH_3; pfam12836 983545003396 tartrate dehydrogenase; Provisional; Region: PRK08194 983545003397 Isocitrate/isopropylmalate dehydrogenase; Region: Iso_dh; cl00445 983545003398 Protein of unknown function (DUF3192); Region: DUF3192; pfam11399 983545003399 Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695 983545003400 Domain of unknown function (DUF3412); Region: DUF3412; pfam11892 983545003401 7-cyano-7-deazaguanine reductase; Provisional; Region: queF; PRK11792 983545003402 Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1), 6-pyrovoyl...; Region: TFold; cl00263 983545003403 Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1), 6-pyrovoyl...; Region: TFold; cl00263 983545003404 Syd protein (SUKH-2); Region: Syd; cl06405 983545003405 hypothetical protein; Provisional; Region: PRK11239 983545003406 Protein of unknown function (DUF3192); Region: DUF3192; pfam11399 983545003407 Protein of unknown function (DUF2789); Region: DUF2789; pfam10982 983545003408 Protein of unknown function (DUF3301); Region: DUF3301; pfam11743 983545003409 Protein of unknown function (DUF3549); Region: DUF3549; pfam12069 983545003410 tRNA pseudouridine synthase C; Region: DUF446; cl01187 983545003411 tRNA pseudouridine isomerase C: Pseudouridine synthases catalyze the isomerization of specific uridines in an tRNA molecule to pseudouridines (5-ribosyluracil, psi). No cofactors are required. TruC makes psi65 in tRNAs. This psi residue is not...; Region: PseudoU_synth_TruC; cd02563 983545003412 probable active site [active] 983545003413 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 983545003414 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 983545003415 PA_M28_2: Protease-associated (PA) domain, peptidase family M28, subfamily-2. A subfamily of PA-domain containing proteins belonging to the peptidase family M28. Family M28 contains aminopeptidases and carboxypeptidases, and has co-catalytic zinc ions; Region: PA_M28_2; cd04815 983545003416 PA/protease or protease-like domain interface [polypeptide binding]; other site 983545003417 M28 Zn-Peptidase Plasma glutamate carboxypeptidase; Region: M28_Pgcp_like; cd03883 983545003418 metal binding site [ion binding]; metal-binding site 983545003419 Ribosomal protein S20; Region: Ribosomal_S20p; cl00384 983545003420 Uncharacterized membrane protein, putative virulence factor [General function prediction only]; Region: MviN; COG0728 983545003421 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 983545003422 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 983545003423 active site 983545003424 Riboflavin kinase; Region: Flavokinase; cl03312 983545003425 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743 983545003426 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 983545003427 active site 983545003428 HIGH motif; other site 983545003429 nucleotide binding site [chemical binding]; other site 983545003430 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 983545003431 active site 983545003432 KMSKS motif; other site 983545003433 Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960 983545003434 tRNA binding surface [nucleotide binding]; other site 983545003435 anticodon binding site; other site 983545003436 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 983545003437 Signal peptidase (SPase) II; Region: Peptidase_A8; cl00458 983545003438 lipoprotein signal peptidase; Provisional; Region: PRK14787 983545003439 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; cl11587 983545003440 LytB protein; Region: LYTB; cl00507 983545003441 (E)-4-hydroxy-3-methyl-but-2-enyl pyrophosphate reductase (IPP and DMAPP forming); Region: ispH_lytB; TIGR00216 983545003442 type IV pilus modification protein PilV; Region: type_IV_pilV; TIGR02523 983545003443 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; cl06830 983545003444 Tfp pilus assembly protein PilW [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilW; COG4966 983545003445 PilX N-terminal; Region: PilX_N; pfam14341 983545003446 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 983545003447 Neisseria PilC beta-propeller domain; Region: Neisseria_PilC; pfam05567 983545003448 Tfp pilus assembly protein PilE [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilE; COG4968 983545003449 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; cl06830 983545003450 Tfp pilus assembly protein FimT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimT; COG4970 983545003451 Type II transport protein GspH; Region: GspH; pfam12019 983545003452 Tfp pilus assembly protein PilE [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilE; COG4968 983545003453 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; cl06830 983545003454 hypothetical protein; Provisional; Region: PRK10506 983545003455 Type II transport protein GspH; Region: GspH; pfam12019 983545003456 hypothetical protein; Provisional; Region: PRK10557 983545003457 Tfp pilus assembly protein PilV [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilV; COG4967 983545003458 NAD synthase [Coenzyme metabolism]; Region: NadE; COG0171 983545003459 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 983545003460 homodimer interface [polypeptide binding]; other site 983545003461 NAD binding pocket [chemical binding]; other site 983545003462 ATP binding pocket [chemical binding]; other site 983545003463 Mg binding site [ion binding]; other site 983545003464 active-site loop [active] 983545003465 Nitrogen regulatory protein P-II; Region: P-II; cl00412 983545003466 Nitrogen regulatory protein P-II; Region: P-II; smart00938 983545003467 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; cl11587 983545003468 FKBP-type peptidyl-prolyl cis-trans isomerases 2 [Posttranslational modification, protein turnover, chaperones]; Region: SlpA; COG1047 983545003469 putative global regulator; Reviewed; Region: PRK09559 983545003470 folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317 983545003471 Flavinator of succinate dehydrogenase; Region: Sdh5; cl01110 983545003472 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 983545003473 active site 2 [active] 983545003474 active site 1 [active] 983545003475 L-aspartate oxidase; Provisional; Region: PRK09077 983545003476 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 983545003477 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 983545003478 RNA polymerase sigma factor AlgU; Provisional; Region: algU; PRK11923 983545003479 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 983545003480 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 983545003481 DNA binding residues [nucleotide binding] 983545003482 anti-RNA polymerase sigma factor SigE; Provisional; Region: PRK10863 983545003483 Anti sigma-E protein RseA, N-terminal domain; Region: RseA_N; pfam03872 983545003484 Anti sigma-E protein RseA, C-terminal domain; Region: RseA_C; pfam03873 983545003485 Outer membrane lipoprotein carrier protein LolA; Region: LolA; cl01065 983545003486 MucB/RseB family; Region: MucB_RseB; pfam03888 983545003487 Positive regulator of sigma(E), RseC/MucC; Region: RseC_MucC; cl01178 983545003488 GTP-binding protein LepA; Provisional; Region: PRK05433 983545003489 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 983545003490 G1 box; other site 983545003491 putative GEF interaction site [polypeptide binding]; other site 983545003492 GTP/Mg2+ binding site [chemical binding]; other site 983545003493 Switch I region; other site 983545003494 G2 box; other site 983545003495 G3 box; other site 983545003496 Switch II region; other site 983545003497 G4 box; other site 983545003498 G5 box; other site 983545003499 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 983545003500 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 983545003501 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 983545003502 signal peptidase I; Provisional; Region: PRK10861 983545003503 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 983545003504 Catalytic site [active] 983545003505 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 983545003506 ribonuclease III; Reviewed; Region: rnc; PRK00102 983545003507 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 983545003508 dimerization interface [polypeptide binding]; other site 983545003509 active site 983545003510 metal binding site [ion binding]; metal-binding site 983545003511 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 983545003512 dsRNA binding site [nucleotide binding]; other site 983545003513 GTPase Era; Reviewed; Region: era; PRK00089 983545003514 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 983545003515 G1 box; other site 983545003516 GTP/Mg2+ binding site [chemical binding]; other site 983545003517 Switch I region; other site 983545003518 G2 box; other site 983545003519 Switch II region; other site 983545003520 G3 box; other site 983545003521 G4 box; other site 983545003522 G5 box; other site 983545003523 K homology RNA-binding domain, type I. KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains that...; Region: KH-I; cl00098 983545003524 pyridoxamine-phosphate oxidase; Region: pdxH; TIGR00558 983545003525 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 983545003526 Pyridoxine 5'-phosphate oxidase C-terminal dimerisation region; Region: PNPOx_C; pfam10590 983545003527 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 983545003528 active site 983545003529 gliding motility-associated ABC transporter ATP-binding subunit GldA; Region: GldA_ABC_ATP; TIGR03522 983545003530 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 983545003531 Walker A/P-loop; other site 983545003532 ATP binding site [chemical binding]; other site 983545003533 Q-loop/lid; other site 983545003534 ABC transporter signature motif; other site 983545003535 Walker B; other site 983545003536 D-loop; other site 983545003537 H-loop/switch region; other site 983545003538 ABC-2 type transporter; Region: ABC2_membrane; cl11417 983545003539 ABC-type uncharacterized transport system; Region: ABC_transp_aux; pfam09822 983545003540 Domain of unknown function (DUF4340); Region: DUF4340; pfam14238 983545003541 Protein of unknown function (DUF1415); Region: DUF1415; cl01301 983545003542 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK10792 983545003543 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 983545003544 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 983545003545 homodimer interface [polypeptide binding]; other site 983545003546 NADP binding site [chemical binding]; other site 983545003547 substrate binding site [chemical binding]; other site 983545003548 trigger factor; Provisional; Region: tig; PRK01490 983545003549 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; cl11587 983545003550 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 983545003551 Clp protease; Region: CLP_protease; pfam00574 983545003552 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 983545003553 oligomer interface [polypeptide binding]; other site 983545003554 active site residues [active] 983545003555 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 983545003556 ClpX C4-type zinc finger; Region: zf-C4_ClpX; cl05964 983545003557 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 983545003558 Walker A motif; other site 983545003559 ATP binding site [chemical binding]; other site 983545003560 Walker B motif; other site 983545003561 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; cl11083 983545003562 DNA-binding ATP-dependent protease La; Provisional; Region: PRK10787 983545003563 Found in ATP-dependent protease La (LON); Region: LON; smart00464 983545003564 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 983545003565 Walker A motif; other site 983545003566 ATP binding site [chemical binding]; other site 983545003567 Walker B motif; other site 983545003568 arginine finger; other site 983545003569 Subunit ChlI of Mg-chelatase; Region: ChlI; cl12214 983545003570 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 983545003571 IHF dimer interface [polypeptide binding]; other site 983545003572 IHF - DNA interface [nucleotide binding]; other site 983545003573 periplasmic folding chaperone; Provisional; Region: PRK10788 983545003574 SurA N-terminal domain; Region: SurA_N_3; cl07813 983545003575 PPIC-type PPIASE domain; Region: Rotamase; cl08278 983545003576 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 983545003577 active site 983545003578 multimer interface [polypeptide binding]; other site 983545003579 ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK11194 983545003580 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 983545003581 FeS/SAM binding site; other site 983545003582 type IV pilus biogenesis/stability protein PilW; Region: type_IV_pilW; TIGR02521 983545003583 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 983545003584 binding surface 983545003585 TPR motif; other site 983545003586 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 983545003587 TPR motif; other site 983545003588 binding surface 983545003589 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118 983545003590 putative peptidoglycan binding site; other site 983545003591 cytoskeletal protein RodZ; Provisional; Region: PRK10856 983545003592 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 983545003593 Domain of unknown function (DUF4115); Region: DUF4115; pfam13464 983545003594 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366 983545003595 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 983545003596 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 983545003597 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 983545003598 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: HisRS-like_core; cd00773 983545003599 dimer interface [polypeptide binding]; other site 983545003600 motif 1; other site 983545003601 active site 983545003602 motif 2; other site 983545003603 motif 3; other site 983545003604 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 983545003605 anticodon binding site; other site 983545003606 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2976 983545003607 Uncharacterized protein conserved in bacteria (DUF2133); Region: DUF2133; pfam09976 983545003608 outer membrane biogenesis protein BamB; Provisional; Region: PRK11138 983545003609 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493 983545003610 Trp docking motif [polypeptide binding]; other site 983545003611 active site 983545003612 GTP-binding protein Der; Reviewed; Region: PRK00093 983545003613 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 983545003614 G1 box; other site 983545003615 GTP/Mg2+ binding site [chemical binding]; other site 983545003616 Switch I region; other site 983545003617 G2 box; other site 983545003618 Switch II region; other site 983545003619 G3 box; other site 983545003620 G4 box; other site 983545003621 G5 box; other site 983545003622 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 983545003623 G1 box; other site 983545003624 GTP/Mg2+ binding site [chemical binding]; other site 983545003625 Switch I region; other site 983545003626 G2 box; other site 983545003627 G3 box; other site 983545003628 Switch II region; other site 983545003629 G4 box; other site 983545003630 G5 box; other site 983545003631 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 983545003632 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 983545003633 generic binding surface II; other site 983545003634 generic binding surface I; other site 983545003635 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 983545003636 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl09108 983545003637 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a key...; Region: CBS_pair_IMPDH; cd04601 983545003638 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of the guanine...; Region: IMPDH; cd00381 983545003639 active site 983545003640 GMP synthase; Reviewed; Region: guaA; PRK00074 983545003641 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 983545003642 AMP/PPi binding site [chemical binding]; other site 983545003643 candidate oxyanion hole; other site 983545003644 catalytic triad [active] 983545003645 potential glutamine specificity residues [chemical binding]; other site 983545003646 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 983545003647 ATP Binding subdomain [chemical binding]; other site 983545003648 Ligand Binding sites [chemical binding]; other site 983545003649 Dimerization subdomain; other site 983545003650 YaeQ protein; Region: YaeQ; cl01913 983545003651 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 983545003652 putative acyl-acceptor binding pocket; other site 983545003653 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 983545003654 nucleoside/Zn binding site; other site 983545003655 dimer interface [polypeptide binding]; other site 983545003656 catalytic motif [active] 983545003657 membrane-bound lytic transglycosylase F; Provisional; Region: PRK10859 983545003658 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 983545003659 substrate binding pocket [chemical binding]; other site 983545003660 membrane-bound complex binding site; other site 983545003661 hinge residues; other site 983545003662 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic 'goose-type' lysozymes (GEWL). LTs catalyze...; Region: LT_GEWL; cd00254 983545003663 N-acetyl-D-glucosamine binding site [chemical binding]; other site 983545003664 catalytic residue [active] 983545003665 phosphoribosylformylglycinamidine synthase; Provisional; Region: PRK05297 983545003666 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 983545003667 dimerization interface [polypeptide binding]; other site 983545003668 ATP binding site [chemical binding]; other site 983545003669 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 983545003670 dimerization interface [polypeptide binding]; other site 983545003671 ATP binding site [chemical binding]; other site 983545003672 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 983545003673 putative active site [active] 983545003674 catalytic triad [active] 983545003675 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2840 983545003676 Smr domain; Region: Smr; cl02619 983545003677 leukotriene A-4 hydrolase/aminopeptidase; Region: leuko_A4_hydro; TIGR02411 983545003678 Peptidase M1 family contains leukotriene A4 hydrolase; Region: M1_LTA4H; cd09599 983545003679 active site 983545003680 Zn binding site [ion binding]; other site 983545003681 Leukotriene A4 hydrolase, C-terminal; Region: Leuk-A4-hydro_C; pfam09127 983545003682 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 983545003683 Outer membrane receptor for Fe3+-dicitrate [Inorganic ion transport and metabolism]; Region: FecA; COG4772 983545003684 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 983545003685 N-terminal plug; other site 983545003686 ligand-binding site [chemical binding]; other site 983545003687 LPP20 lipoprotein; Region: LPP20; cl15824 983545003688 Anti-sigma-28 factor, FlgM; Region: FlgM; cl01052 983545003689 SAF domain; Region: SAF; cl00555 983545003690 SAF-like; Region: SAF_2; pfam13144 983545003691 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256 983545003692 Response regulator receiver domain; Region: Response_reg; pfam00072 983545003693 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 983545003694 active site 983545003695 phosphorylation site [posttranslational modification] 983545003696 intermolecular recognition site; other site 983545003697 dimerization interface [polypeptide binding]; other site 983545003698 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 983545003699 Methyltransferase, chemotaxis proteins; Region: MeTrc; smart00138 983545003700 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 983545003701 flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK05680 983545003702 Flagella basal body rod protein; Region: Flg_bb_rod; cl15793 983545003703 flagellar basal body rod protein FlgC; Provisional; Region: flgC; PRK12631 983545003704 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; cl15855 983545003705 flagellar basal body rod modification protein; Reviewed; Region: flgD; PRK06655 983545003706 Flagellar hook capping protein - N-terminal region; Region: FlgD; pfam03963 983545003707 FlgD Ig-like domain; Region: FlgD_ig; cl15790 983545003708 flagellar hook protein FlgE; Validated; Region: flgE; PRK05682 983545003709 Flagellar basal body protein FlaE; Region: FlaE; pfam07559 983545003710 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; cl15855 983545003711 flagellar basal body rod protein FlgF; Reviewed; Region: flgF; PRK12640 983545003712 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; cl15855 983545003713 flagellar basal body rod protein FlgG; Provisional; Region: flgG; PRK12693 983545003714 Flagella basal body rod protein; Region: Flg_bb_rod; cl15793 983545003715 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; cl15855 983545003716 flagellar basal body L-ring protein; Reviewed; Region: flgH; PRK12698 983545003717 Flagellar L-ring protein; Region: FlgH; cl00905 983545003718 flagellar basal body P-ring protein; Provisional; Region: flgI; PRK05303 983545003719 flagellar basal body P-ring protein; Reviewed; Region: flgI; cl14622 983545003720 flagellar rod assembly protein/muramidase FlgJ; Validated; Region: flgJ; PRK05684 983545003721 Rod binding protein; Region: Rod-binding; cl01626 983545003722 lysozyme_like domain. This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222 983545003723 flagellar hook-associated protein FlgK; Validated; Region: flgK; PRK05683 983545003724 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; cl15855 983545003725 flagellar hook-associated protein FlgL; Reviewed; Region: flgL; PRK08870 983545003726 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 983545003727 flagellin; Provisional; Region: PRK12802 983545003728 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 983545003729 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 983545003730 flagellin; Provisional; Region: PRK12802 983545003731 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 983545003732 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 983545003733 flagellin; Provisional; Region: PRK12802 983545003734 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 983545003735 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 983545003736 FlaG protein; Region: FlaG; cl00591 983545003737 Flagellar capping protein [Cell motility and secretion]; Region: FliD; COG1345 983545003738 Flagellar hook-associated protein 2 C-terminus; Region: FliD_N; pfam02465 983545003739 Flagellin hook IN motif; Region: Flagellin_IN; pfam07196 983545003740 Flagellar hook-associated protein 2 C-terminus; Region: FliD_C; pfam07195 983545003741 Flagellar protein FliS; Region: FliS; cl00654 983545003742 UDP-N-acetylglucosamine 4,6-dehydratase; Region: PseB; TIGR03589 983545003743 UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237 983545003744 NAD(P) binding site [chemical binding]; other site 983545003745 homodimer interface [polypeptide binding]; other site 983545003746 substrate binding site [chemical binding]; other site 983545003747 active site 983545003748 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 983545003749 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 983545003750 inhibitor-cofactor binding pocket; inhibition site 983545003751 pyridoxal 5'-phosphate binding site [chemical binding]; other site 983545003752 catalytic residue [active] 983545003753 CMP-NeuAc_Synthase activates N-acetylneuraminic acid by adding CMP moiety; Region: CMP-NeuAc_Synthase; cd02513 983545003754 ligand binding site; other site 983545003755 tetramer interface; other site 983545003756 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 983545003757 pseudaminic acid synthase; Region: PseI; TIGR03586 983545003758 NeuB family; Region: NeuB; cl00496 983545003759 SAF domain; Region: SAF; cl00555 983545003760 pseudaminic acid biosynthesis-associated protein PseG; Region: PseG; TIGR03590 983545003761 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 983545003762 pseudaminic acid biosynthesis N-acetyl transferase; Region: PseH; TIGR03585 983545003763 AMP-binding enzyme; Region: AMP-binding; cl15778 983545003764 AMP-binding enzyme; Region: AMP-binding; cl15778 983545003765 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 983545003766 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 983545003767 NAD(P) binding site [chemical binding]; other site 983545003768 active site 983545003769 Predicted nucleoside-diphosphate sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG1086 983545003770 LicD family; Region: LicD; cl01378 983545003771 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 983545003772 Cytidylyltransferase; Region: CTP_transf_2; pfam01467 983545003773 active site 983545003774 nucleotide binding site [chemical binding]; other site 983545003775 HIGH motif; other site 983545003776 KMSKS motif; other site 983545003777 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 983545003778 Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419 983545003779 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 983545003780 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 983545003781 active site 983545003782 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy; cl15773 983545003783 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 983545003784 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 983545003785 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 983545003786 CMP-NeuAc_Synthase activates N-acetylneuraminic acid by adding CMP moiety; Region: CMP-NeuAc_Synthase; cd02513 983545003787 ligand binding site; other site 983545003788 tetramer interface; other site 983545003789 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 983545003790 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain associated with the NTP (Nucleotidyl transferase) domain downstream. CBS is a small domain originally identified in cystathionine beta-synthase and subsequently...; Region: CBS_pair_NTP_transferase_assoc; cd04607 983545003791 N-acetylneuraminate synthase; Region: NeuB_NnaB; TIGR03569 983545003792 NeuB family; Region: NeuB; cl00496 983545003793 SAF domain; Region: SAF; cl00555 983545003794 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 983545003795 Metal-binding active site; metal-binding site 983545003796 AP (apurinic/apyrimidinic) site pocket; other site 983545003797 Thiamin pyrophosphokinase, catalytic domain; Region: TPK_catalytic; cl09135 983545003798 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 983545003799 flagellin; Reviewed; Region: PRK08869 983545003800 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 983545003801 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl09944 983545003802 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 983545003803 Walker A motif; other site 983545003804 ATP binding site [chemical binding]; other site 983545003805 Walker B motif; other site 983545003806 arginine finger; other site 983545003807 Helix-turn-helix domains; Region: HTH; cl00088 983545003808 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 983545003809 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 983545003810 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 983545003811 dimer interface [polypeptide binding]; other site 983545003812 phosphorylation site [posttranslational modification] 983545003813 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 983545003814 ATP binding site [chemical binding]; other site 983545003815 Mg2+ binding site [ion binding]; other site 983545003816 G-X-G motif; other site 983545003817 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 983545003818 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 983545003819 active site 983545003820 phosphorylation site [posttranslational modification] 983545003821 intermolecular recognition site; other site 983545003822 dimerization interface [polypeptide binding]; other site 983545003823 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 983545003824 Walker A motif; other site 983545003825 ATP binding site [chemical binding]; other site 983545003826 Walker B motif; other site 983545003827 arginine finger; other site 983545003828 Helix-turn-helix domains; Region: HTH; cl00088 983545003829 Flagellar hook-basal body complex protein FliE; Region: FliE; cl09139 983545003830 flagellar MS-ring protein; Reviewed; Region: fliF; PRK06007 983545003831 Secretory protein of YscJ/FliF family; Region: YscJ_FliF; cl01907 983545003832 Flagellar M-ring protein C-terminal; Region: YscJ_FliF_C; pfam08345 983545003833 flagellar motor switch protein G; Validated; Region: fliG; PRK05686 983545003834 MgtE intracellular N domain; Region: MgtE_N; cl15244 983545003835 FliG C-terminal domain; Region: FliG_C; pfam01706 983545003836 flagellar assembly protein H; Validated; Region: fliH; PRK05687 983545003837 Essential protein Yae1, N terminal; Region: Yae1_N; pfam09811 983545003838 Flagellar assembly protein FliH; Region: FliH; pfam02108 983545003839 flagellum-specific ATP synthase; Validated; Region: fliI; PRK08972 983545003840 Flagellum-specific ATPase/type III secretory pathway virulence-related protein. This group of ATPases are responsible for the export of flagellum and virulence-related proteins. The bacterial flagellar motor is similar to the F0F1-ATPase, in that they...; Region: ATPase_flagellum-secretory_path_III; cd01136 983545003841 Walker A motif/ATP binding site; other site 983545003842 Walker B motif; other site 983545003843 flagellar biosynthesis chaperone; Validated; Region: fliJ; cl09161 983545003844 Flagellar FliJ protein; Region: FliJ; pfam02050 983545003845 Flagellar hook-length control protein FliK; Region: Flg_hook; cl15269 983545003846 Flagellar basal body-associated protein FliL; Region: FliL; cl00681 983545003847 flagellar motor switch protein FliM; Validated; Region: fliM; PRK06666 983545003848 Surface presentation of antigens (SPOA); Region: SpoA; cl00819 983545003849 Surface presentation of antigens (SPOA); Region: SpoA; cl00819 983545003850 Flagellar biosynthesis protein, FliO; Region: FliO; cl01247 983545003851 FliP family; Region: FliP; cl00593 983545003852 Bacterial export proteins, family 3; Region: Bac_export_3; cl00867 983545003853 Bacterial export proteins, family 1; Region: Bac_export_1; cl00734 983545003854 flagellar biosynthesis protein FlhB; Reviewed; Region: flhB; PRK05702 983545003855 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257; cl15822 983545003856 flagellar biosynthesis protein FlhA; Validated; Region: flhA; cl07980 983545003857 FHIPEP family; Region: FHIPEP; pfam00771 983545003858 flagellar biosynthesis regulator FlhF; Validated; Region: flhF; PRK05703 983545003859 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 983545003860 Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455 983545003861 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 983545003862 FleN is a member of the Fer4_NifH superfamily. It shares the common function as an ATPase, with the ATP-binding domain at the N-terminus. In Pseudomonas aeruginosa, FleN gene is involved in regulating the number of flagella and chemotactic motility by...; Region: FleN-like; cd02038 983545003863 flagellar biosynthesis sigma factor; Validated; Region: fliA; PRK06986 983545003864 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 983545003865 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 983545003866 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 983545003867 DNA binding residues [nucleotide binding] 983545003868 chemotaxis regulatory protein CheY; Provisional; Region: PRK10610 983545003869 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 983545003870 active site 983545003871 phosphorylation site [posttranslational modification] 983545003872 intermolecular recognition site; other site 983545003873 dimerization interface [polypeptide binding]; other site 983545003874 Chemotaxis phosphatase, CheZ; Region: CheZ; cl01219 983545003875 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 983545003876 putative binding surface; other site 983545003877 active site 983545003878 Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895 983545003879 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 983545003880 ATP binding site [chemical binding]; other site 983545003881 Mg2+ binding site [ion binding]; other site 983545003882 G-X-G motif; other site 983545003883 CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731 983545003884 chemotaxis-specific methylesterase; Provisional; Region: PRK00742 983545003885 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 983545003886 active site 983545003887 phosphorylation site [posttranslational modification] 983545003888 intermolecular recognition site; other site 983545003889 dimerization interface [polypeptide binding]; other site 983545003890 CheB methylesterase; Region: CheB_methylest; pfam01339 983545003891 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 983545003892 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 983545003893 Magnesium ion binding site [ion binding]; other site 983545003894 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cd00588 983545003895 CheW, a small regulator protein, unique to the chemotaxis signalling in prokaryotes and archea. CheW interacts with the histidine kinase CheA, most likely with the related regulatory domain of CheA. CheW is proposed to form signalling arrays together...; Region: CheW; cd00732 983545003896 putative CheA interaction surface; other site 983545003897 Protein of unknown function (DUF2802); Region: DUF2802; pfam10975 983545003898 homoserine O-succinyltransferase; Provisional; Region: PRK05368 983545003899 Type 1 glutamine amidotransferase (GATase1)-like domain found in homoserine trans-succinylase (HTS); Region: GATase1_HTS; cd03131 983545003900 proposed active site lysine [active] 983545003901 conserved cys residue [active] 983545003902 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; cl14105 983545003903 Homocysteine S-methyltransferase; Region: S-methyl_trans; pfam02574 983545003904 Methionine synthase I, cobalamin-binding domain [Amino acid transport and metabolism]; Region: MetH; COG1410 983545003905 MeTr subgroup of pterin binding enzymes. This family includes cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). Cobalamin-dependent...; Region: MeTr; cd00740 983545003906 substrate binding pocket [chemical binding]; other site 983545003907 B12 binding domain of methionine synthase. This domain binds methylcobalamin, which it uses as an intermediate methyl carrier from methyltetrahydrofolate (CH3H4folate) to homocysteine (Hcy); Region: methionine_synthase_B12_BD; cd02069 983545003908 B12 binding site [chemical binding]; other site 983545003909 cobalt ligand [ion binding]; other site 983545003910 Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965 983545003911 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 983545003912 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 983545003913 Protein of unknown function, DUF482; Region: DUF482; pfam04339 983545003914 RecX family; Region: RecX; cl00936 983545003915 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 983545003916 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent formation of...; Region: AlaRS_core; cd00673 983545003917 motif 1; other site 983545003918 active site 983545003919 motif 2; other site 983545003920 motif 3; other site 983545003921 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; cl08469 983545003922 DHHA1 domain; Region: DHHA1; pfam02272 983545003923 Global regulator protein family; Region: CsrA; cl00670 983545003924 Oxaloacetate decarboxylase, gamma chain; Region: OAD_gamma; cl01458 983545003925 oxaloacetate decarboxylase; Provisional; Region: PRK14040 983545003926 Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937 983545003927 active site 983545003928 catalytic residues [active] 983545003929 metal binding site [ion binding]; metal-binding site 983545003930 homodimer binding site [polypeptide binding]; other site 983545003931 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 983545003932 carboxyltransferase (CT) interaction site; other site 983545003933 biotinylation site [posttranslational modification]; other site 983545003934 Na+-transporting oxaloacetate decarboxylase beta subunit; Region: OAD_beta; cl00816 983545003935 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SapF; COG4167 983545003936 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 983545003937 Walker A/P-loop; other site 983545003938 ATP binding site [chemical binding]; other site 983545003939 Q-loop/lid; other site 983545003940 ABC transporter signature motif; other site 983545003941 Walker B; other site 983545003942 D-loop; other site 983545003943 H-loop/switch region; other site 983545003944 antimicrobial peptide ABC transporter ATP-binding protein; Provisional; Region: PRK15093 983545003945 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 983545003946 Walker A/P-loop; other site 983545003947 ATP binding site [chemical binding]; other site 983545003948 Q-loop/lid; other site 983545003949 ABC transporter signature motif; other site 983545003950 Walker B; other site 983545003951 D-loop; other site 983545003952 H-loop/switch region; other site 983545003953 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 983545003954 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SapC; COG4171 983545003955 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 983545003956 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 983545003957 dimer interface [polypeptide binding]; other site 983545003958 conserved gate region; other site 983545003959 putative PBP binding loops; other site 983545003960 ABC-ATPase subunit interface; other site 983545003961 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 983545003962 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 983545003963 dimer interface [polypeptide binding]; other site 983545003964 conserved gate region; other site 983545003965 putative PBP binding loops; other site 983545003966 ABC-ATPase subunit interface; other site 983545003967 The substrate-binding component of an ABC-type dipeptide import system contains the type 2 periplasmic binding fold; Region: PBP2_DppA_like; cd08493 983545003968 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 983545003969 peptide binding site [polypeptide binding]; other site 983545003970 psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974 983545003971 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 983545003972 Walker A motif; other site 983545003973 ATP binding site [chemical binding]; other site 983545003974 Walker B motif; other site 983545003975 arginine finger; other site 983545003976 Helix-turn-helix domains; Region: HTH; cl00088 983545003977 phage shock protein A; Region: phageshock_pspA; TIGR02977 983545003978 Phage shock protein B; Region: PspB; cl05946 983545003979 phage shock protein C; Region: phageshock_pspC; TIGR02978 983545003980 PspC domain; Region: PspC; cl00864 983545003981 YcjX-like family, DUF463; Region: DUF463; cl01193 983545003982 hypothetical protein; Provisional; Region: PRK05415 983545003983 Domain of unknown function (DUF697); Region: DUF697; cl12064 983545003984 Prokaryotic phenylalanine-4-hydroxylase (pro_PheOH); a member of the biopterin-dependent aromatic amino acid hydroxylase family of non-heme, iron(II)-dependent enzymes that also includes the eukaryotic proteins, phenylalanine-4-hydroxylase (eu_PheOH); Region: pro_PheOH; cd03348 983545003985 cofactor binding site; other site 983545003986 metal binding site [ion binding]; metal-binding site 983545003987 DNA-binding transcriptional regulator TyrR; Provisional; Region: PRK10820 983545003988 N-terminal ACT domain of the TyrR protein; Region: ACT_TyrR; cd04877 983545003989 putative aromatic amino acid binding site; other site 983545003990 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 983545003991 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 983545003992 Walker A motif; other site 983545003993 ATP binding site [chemical binding]; other site 983545003994 Walker B motif; other site 983545003995 arginine finger; other site 983545003996 4-hydroxyphenylpyruvate dioxygenase and related hemolysins [Amino acid transport and metabolism / General function prediction only]; Region: COG3185 983545003997 N-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HPPD) and hydroxymandelate Synthase (HmaS); Region: HPPD_N_like; cd08342 983545003998 dimer interface [polypeptide binding]; other site 983545003999 C-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HppD) and hydroxymandelate Synthase (HmaS); Region: HPPD_C_like; cd07250 983545004000 active site 983545004001 Fe binding site [ion binding]; other site 983545004002 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 983545004003 Helix-turn-helix domains; Region: HTH; cl00088 983545004004 Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334 983545004005 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 983545004006 NAD(P) binding domain of leucine dehydrogenase, phenylalanine dehydrogenase, and valine dehydrogenase; Region: NAD_bind_Leu_Phe_Val_DH; cd01075 983545004007 NAD binding site [chemical binding]; other site 983545004008 Phe binding site; other site 983545004009 Late competence development protein ComFB; Region: ComFB; pfam10719 983545004010 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl00284 983545004011 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl00284 983545004012 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 983545004013 binding surface 983545004014 TPR motif; other site 983545004015 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 983545004016 binding surface 983545004017 TPR motif; other site 983545004018 Tetratricopeptide repeat; Region: TPR_16; pfam13432 983545004019 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 983545004020 binding surface 983545004021 TPR motif; other site 983545004022 Sulfotransferase family; Region: Sulfotransfer_3; cl14559 983545004023 Methyltransferase domain; Region: Methyltransf_31; pfam13847 983545004024 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 983545004025 Protein of unknown function (DUF3450); Region: DUF3450; pfam11932 983545004026 Protein of unknown function (DUF1090); Region: DUF1090; pfam06476 983545004027 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 983545004028 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 983545004029 Biopolymer transport protein ExbD/TolR; Region: ExbD; cl00537 983545004030 Gram-negative bacterial tonB protein; Region: TonB; cl10048 983545004031 TPR repeat; Region: TPR_11; pfam13414 983545004032 TPR repeat; Region: TPR_11; pfam13414 983545004033 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 983545004034 binding surface 983545004035 TPR motif; other site 983545004036 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 983545004037 binding surface 983545004038 TPR motif; other site 983545004039 putative chaperone; Provisional; Region: PRK11678 983545004040 Protein of unknown function (DUF3087); Region: DUF3087; pfam11286 983545004041 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 983545004042 Uncharacterized conserved protein (DUF2196); Region: DUF2196; cl02044 983545004043 AraC-type transcriptional regulator N-terminus; Region: AraC_N; pfam06719 983545004044 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 983545004045 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 983545004046 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 983545004047 D-cysteine desulfhydrase; Validated; Region: PRK03910 983545004048 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342 983545004049 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 983545004050 catalytic residue [active] 983545004051 endonuclease III; Provisional; Region: PRK10702 983545004052 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 983545004053 minor groove reading motif; other site 983545004054 helix-hairpin-helix signature motif; other site 983545004055 substrate binding pocket [chemical binding]; other site 983545004056 active site 983545004057 Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; cl15304 983545004058 Rnf-Nqr subunit, membrane protein; Region: Rnf-Nqr; cl00597 983545004059 FMN-binding domain; Region: FMN_bind; cl01081 983545004060 NQR2, RnfD, RnfE family; Region: NQR2_RnfD_RnfE; cl00779 983545004061 electron transport complex, RnfABCDGE type, C subunit; Region: rnfC; TIGR01945 983545004062 RnfC Barrel sandwich hybrid domain; Region: RnfC_N; pfam13375 983545004063 Respiratory-chain NADH dehydrogenase 51 Kd subunit; Region: Complex1_51K; pfam01512 983545004064 SLBB domain; Region: SLBB; pfam10531 983545004065 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 983545004066 electron transport complex protein RnfB; Provisional; Region: PRK05113 983545004067 Putative Fe-S cluster; Region: FeS; pfam04060 983545004068 4Fe-4S binding domain; Region: Fer4; cl02805 983545004069 Rnf-Nqr subunit, membrane protein; Region: Rnf-Nqr; cl00597 983545004070 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 983545004071 MatE; Region: MatE; cl10513 983545004072 MatE; Region: MatE; cl10513 983545004073 excinuclease ABC subunit B; Provisional; Region: PRK05298 983545004074 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 983545004075 ATP binding site [chemical binding]; other site 983545004076 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 983545004077 nucleotide binding region [chemical binding]; other site 983545004078 ATP-binding site [chemical binding]; other site 983545004079 Ultra-violet resistance protein B; Region: UvrB; pfam12344 983545004080 UvrB/uvrC motif; Region: UVR; pfam02151 983545004081 Transcriptional regulator [Transcription]; Region: LysR; COG0583 983545004082 Helix-turn-helix domains; Region: HTH; cl00088 983545004083 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 983545004084 dimerization interface [polypeptide binding]; other site 983545004085 MASE1; Region: MASE1; pfam05231 983545004086 CHASE domain; Region: CHASE; cl01369 983545004087 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 983545004088 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 983545004089 dimer interface [polypeptide binding]; other site 983545004090 phosphorylation site [posttranslational modification] 983545004091 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 983545004092 ATP binding site [chemical binding]; other site 983545004093 Mg2+ binding site [ion binding]; other site 983545004094 G-X-G motif; other site 983545004095 Response regulator receiver domain; Region: Response_reg; pfam00072 983545004096 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 983545004097 active site 983545004098 phosphorylation site [posttranslational modification] 983545004099 intermolecular recognition site; other site 983545004100 dimerization interface [polypeptide binding]; other site 983545004101 ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995 983545004102 Ligand Binding Site [chemical binding]; other site 983545004103 Organic radical activating enzymes [Posttranslational modification, protein turnover, chaperones]; Region: NrdG; COG0602 983545004104 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 983545004105 Yhdh and yhfp-like putative quinone oxidoreductases; Region: MDR_yhdh_yhfp; cd05280 983545004106 putative quinone oxidoreductase, YhdH/YhfP family; Region: oxido_YhdH; TIGR02823 983545004107 NADP binding site [chemical binding]; other site 983545004108 dimer interface [polypeptide binding]; other site 983545004109 hypothetical protein; Provisional; Region: PRK06194 983545004110 classical (c) SDRs; Region: SDR_c; cd05233 983545004111 NAD(P) binding site [chemical binding]; other site 983545004112 active site 983545004113 asparagine synthetase B; Provisional; Region: asnB; PRK09431 983545004114 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 983545004115 active site 983545004116 dimer interface [polypeptide binding]; other site 983545004117 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 983545004118 Ligand Binding Site [chemical binding]; other site 983545004119 Molecular Tunnel; other site 983545004120 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 983545004121 PA_M28_1_2: Protease-associated (PA) domain, peptidase family M28, subfamily-1, subgroup 2. A subgroup of PA-domain containing proteins belonging to the peptidase family M28. Family M28 contains aminopeptidases and carboxypeptidases, and has co-catalytic...; Region: PA_M28_1_2; cd04821 983545004122 Predicted aminopeptidases [General function prediction only]; Region: Iap; COG2234 983545004123 PA/protease or protease-like domain interface [polypeptide binding]; other site 983545004124 M28 Zn-Peptidases containing a PA domain insert; Region: M28_like_PA_1; cd05660 983545004125 metal binding site [ion binding]; metal-binding site 983545004126 Protein of unknown function (DUF3025); Region: DUF3025; pfam11227 983545004127 Yip1 domain; Region: Yip1; cl12048 983545004128 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 983545004129 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 983545004130 Walker A/P-loop; other site 983545004131 ATP binding site [chemical binding]; other site 983545004132 Q-loop/lid; other site 983545004133 ABC transporter signature motif; other site 983545004134 Walker B; other site 983545004135 D-loop; other site 983545004136 H-loop/switch region; other site 983545004137 ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668 983545004138 ABC-2 type transporter; Region: ABC2_membrane; cl11417 983545004139 Protein of unknown function DUF72; Region: DUF72; cl00777 983545004140 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 983545004141 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 983545004142 dimer interface [polypeptide binding]; other site 983545004143 anticodon binding site; other site 983545004144 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of the...; Region: AspRS_core; cd00777 983545004145 homodimer interface [polypeptide binding]; other site 983545004146 motif 1; other site 983545004147 active site 983545004148 motif 2; other site 983545004149 GAD domain; Region: GAD; pfam02938 983545004150 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it attaches...; Region: class_II_aaRS-like_core; cl00268 983545004151 active site 983545004152 motif 3; other site 983545004153 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_7; cd04664 983545004154 nudix motif; other site 983545004155 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD includes...; Region: RuvC_resolvase; cd00529 983545004156 active site 983545004157 putative DNA-binding cleft [nucleotide binding]; other site 983545004158 dimer interface [polypeptide binding]; other site 983545004159 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 983545004160 RuvA N terminal domain; Region: RuvA_N; pfam01330 983545004161 RuvA, C-terminal domain; Region: RuvA_C; pfam07499 983545004162 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 983545004163 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 983545004164 Walker A motif; other site 983545004165 ATP binding site [chemical binding]; other site 983545004166 Walker B motif; other site 983545004167 arginine finger; other site 983545004168 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 983545004169 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 983545004170 active site 983545004171 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 983545004172 Biopolymer transport protein ExbD/TolR; Region: ExbD; cl00537 983545004173 Gram-negative bacterial tonB protein; Region: TonB; cl10048 983545004174 translocation protein TolB; Provisional; Region: tolB; PRK04792 983545004175 TolB amino-terminal domain; Region: TolB_N; cl00639 983545004176 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 983545004177 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 983545004178 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 983545004179 peptidoglycan-associated outer membrane lipoprotein; Provisional; Region: PRK10802 983545004180 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 983545004181 ligand binding site [chemical binding]; other site 983545004182 tol-pal system protein YbgF; Provisional; Region: PRK10803 983545004183 Tetratricopeptide repeat; Region: TPR_6; pfam13174 983545004184 Tetratricopeptide repeat; Region: TPR_6; pfam13174 983545004185 HDOD domain; Region: HDOD; pfam08668 983545004186 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat2; cd03445 983545004187 Thioesterase-like superfamily; Region: 4HBT_3; pfam13622 983545004188 active site 983545004189 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 983545004190 active site 2 [active] 983545004191 active site 1 [active] 983545004192 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 983545004193 Major Facilitator Superfamily; Region: MFS_1; pfam07690 983545004194 putative substrate translocation pore; other site 983545004195 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 983545004196 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 983545004197 glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK00725 983545004198 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 983545004199 ligand binding site; other site 983545004200 oligomer interface; other site 983545004201 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 983545004202 dimer interface [polypeptide binding]; other site 983545004203 N-terminal domain interface [polypeptide binding]; other site 983545004204 sulfate 1 binding site; other site 983545004205 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_1; cd07818 983545004206 putative hydrophobic ligand binding site [chemical binding]; other site 983545004207 3-hydroxy-3-methylglutaryl-CoA lyase, catalytic TIM barrel domain; Region: DRE_TIM_HMGL; cd07938 983545004208 active site 983545004209 catalytic residues [active] 983545004210 metal binding site [ion binding]; metal-binding site 983545004211 Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770 983545004212 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 983545004213 ATP-grasp domain; Region: ATP-grasp_4; cl03087 983545004214 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; cl08365 983545004215 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 983545004216 carboxyltransferase (CT) interaction site; other site 983545004217 biotinylation site [posttranslational modification]; other site 983545004218 enoyl-CoA hydratase; Provisional; Region: PRK05995 983545004219 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 983545004220 substrate binding site [chemical binding]; other site 983545004221 oxyanion hole (OAH) forming residues; other site 983545004222 trimer interface [polypeptide binding]; other site 983545004223 3-methylcrotonyl-CoA carboxylase, beta chain; Region: PLN02820 983545004224 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl15772 983545004225 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl15772 983545004226 Isovaleryl-CoA dehydrogenase; Region: IVD; cd01156 983545004227 isovaleryl-CoA dehydrogenase; Region: PLN02519 983545004228 substrate binding site [chemical binding]; other site 983545004229 FAD binding site [chemical binding]; other site 983545004230 catalytic base [active] 983545004231 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 983545004232 Helix-Turn-Helix DNA binding domain of the regulatory protein GnyR; Region: HTH_GnyR; cd04776 983545004233 DNA binding residues [nucleotide binding] 983545004234 putative dimer interface [polypeptide binding]; other site 983545004235 acetyl-CoA acetyltransferase; Provisional; Region: PRK06954 983545004236 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 983545004237 dimer interface [polypeptide binding]; other site 983545004238 active site 983545004239 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 983545004240 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 983545004241 kynureninase; Region: kynureninase; TIGR01814 983545004242 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 983545004243 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 983545004244 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 983545004245 catalytic residue [active] 983545004246 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 983545004247 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 983545004248 active site 983545004249 phosphorylation site [posttranslational modification] 983545004250 intermolecular recognition site; other site 983545004251 dimerization interface [polypeptide binding]; other site 983545004252 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 983545004253 binding surface 983545004254 TPR motif; other site 983545004255 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 983545004256 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 983545004257 HIGH motif; other site 983545004258 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 983545004259 active site 983545004260 KMSKS motif; other site 983545004261 Protein of unknown function (DUF1289); Region: DUF1289; cl01304 983545004262 tRNA-dihydrouridine synthase C; Provisional; Region: PRK10550 983545004263 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 983545004264 FMN binding site [chemical binding]; other site 983545004265 active site 983545004266 catalytic residues [active] 983545004267 substrate binding site [chemical binding]; other site 983545004268 Lysophospholipase L1-like subgroup of SGNH-hydrolases. The best characterized member in this family is TesA, an E. coli periplasmic protein with thioesterase, esterase, arylesterase, protease and lysophospholipase activity; Region: Lysophospholipase_L1_like; cd01822 983545004269 active site 983545004270 catalytic triad [active] 983545004271 oxyanion hole [active] 983545004272 switch loop; other site 983545004273 Predicted ABC-type transport system involved in lysophospholipase L1 biosynthesis, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG4181 983545004274 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 983545004275 Walker A/P-loop; other site 983545004276 ATP binding site [chemical binding]; other site 983545004277 Q-loop/lid; other site 983545004278 ABC transporter signature motif; other site 983545004279 Walker B; other site 983545004280 D-loop; other site 983545004281 H-loop/switch region; other site 983545004282 Predicted ABC-type transport system involved in lysophospholipase L1 biosynthesis, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3127 983545004283 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 983545004284 FtsX-like permease family; Region: FtsX; cl15850 983545004285 FtsX-like permease family; Region: FtsX; cl15850 983545004286 TIGR01777 family protein; Region: yfcH 983545004287 atypical (a) SDRs, subgroup 8; Region: SDR_a8; cd05242 983545004288 putative NAD(P) binding site [chemical binding]; other site 983545004289 putative active site [active] 983545004290 Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1), 6-pyrovoyl...; Region: TFold; cl00263 983545004291 active site 983545004292 pheromone autoinducer 2 transporter; Reviewed; Region: tqsA; cl00465 983545004293 Domain of unknown function DUF20; Region: UPF0118; pfam01594 983545004294 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 983545004295 NAD(P) binding site [chemical binding]; other site 983545004296 active site 983545004297 Transcriptional regulator [Transcription]; Region: LysR; COG0583 983545004298 Helix-turn-helix domains; Region: HTH; cl00088 983545004299 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 983545004300 putative effector binding pocket; other site 983545004301 dimerization interface [polypeptide binding]; other site 983545004302 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 983545004303 metal binding site [ion binding]; metal-binding site 983545004304 active site 983545004305 I-site; other site 983545004306 Protein of unknown function (DUF692); Region: DUF692; cl01263 983545004307 Uncharacterized protein conserved in bacteria (DUF2063); Region: DUF2063; cl01262 983545004308 Adenine/guanine phosphoribosyltransferases and related PRPP-binding proteins [Nucleotide transport and metabolism]; Region: Apt; COG0503 983545004309 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 983545004310 active site 983545004311 DNA polymerase III, subunit gamma and tau; Region: dnaX_nterm; TIGR02397 983545004312 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 983545004313 Walker A motif; other site 983545004314 ATP binding site [chemical binding]; other site 983545004315 Walker B motif; other site 983545004316 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 983545004317 arginine finger; other site 983545004318 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 983545004319 DNA polymerase III subunits gamma and tau; Validated; Region: PRK07994 983545004320 DNA polymerase III tau subunit V interacting with alpha; Region: DNA_pol3_tau_5; pfam12170 983545004321 YbaB/EbfC DNA-binding family; Region: YbaB_DNA_bd; cl00494 983545004322 recombination protein RecR; Reviewed; Region: recR; PRK00076 983545004323 RecR protein; Region: RecR; pfam02132 983545004324 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 983545004325 putative active site [active] 983545004326 putative metal-binding site [ion binding]; other site 983545004327 tetramer interface [polypeptide binding]; other site 983545004328 heat shock protein 90; Provisional; Region: PRK05218 983545004329 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 983545004330 ATP binding site [chemical binding]; other site 983545004331 Mg2+ binding site [ion binding]; other site 983545004332 G-X-G motif; other site 983545004333 adenylate kinase; Reviewed; Region: adk; PRK00279 983545004334 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 983545004335 AMP-binding site [chemical binding]; other site 983545004336 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 983545004337 MAPEG family; Region: MAPEG; cl09190 983545004338 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 983545004339 Alpha-crystallin domain (ACD) found in Escherichia coli inclusion body-associated proteins IbpA and IbpB, and similar proteins. IbpA and IbpB are 16 kDa small heat shock proteins (sHsps). sHsps are molecular chaperones that suppress protein aggregation...; Region: ACD_IbpA-B_like; cd06470 983545004340 putative dimer interface [polypeptide binding]; other site 983545004341 YceI-like domain; Region: YceI; cl01001 983545004342 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859 983545004343 Phosphoribosyl-AMP cyclohydrolase; Region: PRA-CH; cl00344 983545004344 bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase protein; Reviewed; Region: PRK02759 983545004345 MazG nucleotide pyrophosphohydrolase domain; Region: MazG; cl00345 983545004346 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 983545004347 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 983545004348 substrate binding site [chemical binding]; other site 983545004349 glutamase interaction surface [polypeptide binding]; other site 983545004350 branched-chain amino acid aminotransferase; Provisional; Region: PRK13357 983545004351 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 983545004352 homodimer interface [polypeptide binding]; other site 983545004353 substrate-cofactor binding pocket; other site 983545004354 catalytic residue [active] 983545004355 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 983545004356 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 983545004357 catalytic residues [active] 983545004358 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13170 983545004359 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 983545004360 putative active site [active] 983545004361 oxyanion strand; other site 983545004362 catalytic triad [active] 983545004363 imidazole glycerol-phosphate dehydratase/histidinol phosphatase; Provisional; Region: PRK05446 983545004364 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 983545004365 active site 983545004366 motif I; other site 983545004367 motif II; other site 983545004368 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 983545004369 putative active site pocket [active] 983545004370 4-fold oligomerization interface [polypeptide binding]; other site 983545004371 metal binding residues [ion binding]; metal-binding site 983545004372 3-fold/trimer interface [polypeptide binding]; other site 983545004373 histidinol-phosphate aminotransferase; Region: hisC; TIGR01141 983545004374 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 983545004375 pyridoxal 5'-phosphate binding site [chemical binding]; other site 983545004376 homodimer interface [polypeptide binding]; other site 983545004377 catalytic residue [active] 983545004378 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 983545004379 histidinol dehydrogenase; Region: hisD; TIGR00069 983545004380 NAD binding site [chemical binding]; other site 983545004381 dimerization interface [polypeptide binding]; other site 983545004382 product binding site; other site 983545004383 substrate binding site [chemical binding]; other site 983545004384 zinc binding site [ion binding]; other site 983545004385 catalytic residues [active] 983545004386 ATP phosphoribosyltransferase; Reviewed; Region: hisG; PRK00489 983545004387 ATP phosphoribosyltransferase; Region: HisG; cl15266 983545004388 HisG, C-terminal domain; Region: HisG_C; cl06867 983545004389 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 983545004390 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 983545004391 active site 983545004392 catalytic tetrad [active] 983545004393 Clavaminic acid synthetase (CAS) -like; CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cl00184 983545004394 Conserved hypothetical protein 698; Region: Cons_hypoth698; cl01075 983545004395 sulfite oxidase; Provisional; Region: PLN00177 983545004396 Subgroup of sulfite oxidase (SO) family molybdopterin binding domains that contains conserved dimerization domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate...; Region: SO_family_Moco_dimer; cd02110 983545004397 Moco binding site; other site 983545004398 metal coordination site [ion binding]; other site 983545004399 dimerization interface [polypeptide binding]; other site 983545004400 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 983545004401 Helix-turn-helix domains; Region: HTH; cl00088 983545004402 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 983545004403 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 983545004404 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 983545004405 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 983545004406 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 983545004407 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 983545004408 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 983545004409 Cd(II)/Pb(II)-responsive transcriptional regulator; Region: CadR-PbrR; TIGR02047 983545004410 Helix-Turn-Helix DNA binding domain of the CadR and PbrR transcription regulators; Region: HTH_CadR-PbrR; cd04784 983545004411 DNA binding residues [nucleotide binding] 983545004412 dimer interface [polypeptide binding]; other site 983545004413 putative metal binding site [ion binding]; other site 983545004414 Cation efflux family; Region: Cation_efflux; cl00316 983545004415 TonB-dependent Receptor Plug Domain; Region: Plug; cl08461 983545004416 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 983545004417 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 983545004418 ligand-binding site [chemical binding]; other site 983545004419 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 983545004420 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441 983545004421 DctM-like transporters; Region: DctM; pfam06808 983545004422 C4-dicarboxylate anaerobic carrier; Region: DcuC; cl15356 983545004423 Tripartite ATP-independent periplasmic transporters, DctQ component; Region: DctQ; cl01181 983545004424 Galactose mutarotase-like; Region: Gal_mutarotas_2; pfam13802 983545004425 YicI alpha-xylosidase is a glycosyl hydrolase family 31 (GH31) enzyme that catalyzes the release of an alpha-xylosyl residue from the non-reducing end of alpha-xyloside substrates such as alpha-xylosyl fluoride and isoprimeverose. YicI forms a...; Region: GH31_xylosidase_YicI; cd06593 983545004426 active site 983545004427 homotrimer interface [polypeptide binding]; other site 983545004428 catalytic site [active] 983545004429 homohexamer (dimer of homotrimers) interface [polypeptide binding]; other site 983545004430 OpgC protein; Region: OpgC_C; cl00792 983545004431 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 983545004432 metal binding site [ion binding]; metal-binding site 983545004433 active site 983545004434 I-site; other site 983545004435 HDOD domain; Region: HDOD; pfam08668 983545004436 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 983545004437 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3602 983545004438 ACT domain; Region: ACT_3; pfam10000 983545004439 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 983545004440 enoyl-CoA hydratase; Provisional; Region: PRK06688 983545004441 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 983545004442 substrate binding site [chemical binding]; other site 983545004443 oxyanion hole (OAH) forming residues; other site 983545004444 trimer interface [polypeptide binding]; other site 983545004445 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 983545004446 Helix-turn-helix domains; Region: HTH; cl00088 983545004447 Predicted alpha/beta hydrolase [General function prediction only]; Region: COG4757 983545004448 Protein of unknown function (DUF1418); Region: DUF1418; cl11648 983545004449 cytochrome c oxidase, subunit II; Region: CoxB; TIGR02866 983545004450 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; cl11412 983545004451 Cytochrome c; Region: Cytochrom_C; cl11414 983545004452 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 983545004453 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 983545004454 D-pathway; other site 983545004455 Putative ubiquinol binding site [chemical binding]; other site 983545004456 Low-spin heme (heme b) binding site [chemical binding]; other site 983545004457 Putative water exit pathway; other site 983545004458 Binuclear center (heme o3/CuB) [ion binding]; other site 983545004459 K-pathway; other site 983545004460 Putative proton exit pathway; other site 983545004461 Cytochrome c oxidase subunit IV; Region: Cyt_c_ox_IV; pfam12270 983545004462 Heme-copper oxidase subunit III. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which couple the reduction of molecular oxygen to water to, proton pumping across the membrane. The...; Region: Heme_Cu_Oxidase_III_like; cd00386 983545004463 Subunit I/III interface [polypeptide binding]; other site 983545004464 Cytochrome c oxidase caa3 assembly factor (Caa3_CtaG); Region: Caa3_CtaG; cl09173 983545004465 Cytochrome c; Region: Cytochrom_C; cl11414 983545004466 Cytochrome c; Region: Cytochrom_C; cl11414 983545004467 Cytochrome c; Region: Cytochrom_C; cl11414 983545004468 Family description; Region: VCBS; pfam13517 983545004469 Family description; Region: VCBS; pfam13517 983545004470 Family description; Region: VCBS; pfam13517 983545004471 ASPIC and UnbV; Region: UnbV_ASPIC; pfam07593 983545004472 Bacterial Ig-like domain (group 2); Region: Big_2; cl02708 983545004473 Bacterial Ig-like domain (group 2); Region: Big_2; cl02708 983545004474 Family description; Region: VCBS; pfam13517 983545004475 Family description; Region: VCBS; pfam13517 983545004476 Family description; Region: VCBS; pfam13517 983545004477 Family description; Region: VCBS; pfam13517 983545004478 Family description; Region: VCBS; pfam13517 983545004479 ASPIC and UnbV; Region: UnbV_ASPIC; pfam07593 983545004480 Peptidase family M48; Region: Peptidase_M48; cl12018 983545004481 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_1; cd02199 983545004482 homotrimer interaction site [polypeptide binding]; other site 983545004483 putative active site [active] 983545004484 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 983545004485 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 983545004486 catalytic residue [active] 983545004487 2-isopropylmalate synthase; Validated; Region: PRK03739 983545004488 Mycobacterium tuberculosis LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA; cd07942 983545004489 active site 983545004490 catalytic residues [active] 983545004491 metal binding site [ion binding]; metal-binding site 983545004492 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; cl07212 983545004493 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 983545004494 Helix-turn-helix domains; Region: HTH; cl00088 983545004495 LysE type translocator; Region: LysE; cl00565 983545004496 LysR family transcriptional regulator; Provisional; Region: PRK14997 983545004497 Helix-turn-helix domains; Region: HTH; cl00088 983545004498 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 983545004499 dimerization interface [polypeptide binding]; other site 983545004500 Pirin-related protein [General function prediction only]; Region: COG1741 983545004501 Cupin domain; Region: Cupin_2; cl09118 983545004502 Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726 983545004503 Protein of unknown function (DUF2798); Region: DUF2798; pfam11391 983545004504 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 983545004505 NAD(P) binding site [chemical binding]; other site 983545004506 active site 983545004507 Domain of unknown function (DUF1772); Region: DUF1772; cl12097 983545004508 Cupin domain; Region: Cupin_2; cl09118 983545004509 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 983545004510 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 983545004511 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 983545004512 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 983545004513 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 983545004514 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 983545004515 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 983545004516 non-specific DNA binding site [nucleotide binding]; other site 983545004517 salt bridge; other site 983545004518 sequence-specific DNA binding site [nucleotide binding]; other site 983545004519 aminotransferase; Validated; Region: PRK07337 983545004520 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 983545004521 pyridoxal 5'-phosphate binding site [chemical binding]; other site 983545004522 homodimer interface [polypeptide binding]; other site 983545004523 catalytic residue [active] 983545004524 Outer membrane cobalamin receptor protein [Coenzyme metabolism]; Region: BtuB; COG4206 983545004525 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 983545004526 N-terminal plug; other site 983545004527 ligand-binding site [chemical binding]; other site 983545004528 Bacterial proteins similar to Porphyromonas gingivalis HmuY; Region: HmuY_like; cd07472 983545004529 Bacterial proteins similar to Porphyromonas gingivalis HmuY; Region: HmuY_like; cd07472 983545004530 ABC-type hemin transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: ChuT; COG4558 983545004531 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 983545004532 intersubunit interface [polypeptide binding]; other site 983545004533 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 983545004534 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 983545004535 ABC-ATPase subunit interface; other site 983545004536 dimer interface [polypeptide binding]; other site 983545004537 putative PBP binding regions; other site 983545004538 hemin importer ATP-binding subunit; Provisional; Region: hmuV; PRK13548 983545004539 ABC transporters, involved in the uptake of siderophores, heme, and vitamin B12, are widely conserved in bacteria and archaea. Only very few species lack representatives of the siderophore family transporters. The E. coli BtuCD protein is an ABC...; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 983545004540 Walker A/P-loop; other site 983545004541 ATP binding site [chemical binding]; other site 983545004542 Q-loop/lid; other site 983545004543 ABC transporter signature motif; other site 983545004544 Walker B; other site 983545004545 D-loop; other site 983545004546 H-loop/switch region; other site 983545004547 Putative heme iron utilization protein [Inorganic ion transport and metabolism]; Region: HugZ; COG0748 983545004548 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 983545004549 Protein of unknown function (DUF2470); Region: DUF2470; pfam10615 983545004550 Endolysins and autolysins are found in viruses and bacteria, respectively. The ds DNA phages of eubacteria use endolysins or muralytic enzymes in conjunction with hollin, a small membrane protein, to degrade the peptidoglycan found in bacterial cell...; Region: endolysin_autolysin; cd00737 983545004551 catalytic residues [active] 983545004552 Ion channel; Region: Ion_trans_2; cl11596 983545004553 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 983545004554 metal binding site [ion binding]; metal-binding site 983545004555 active site 983545004556 I-site; other site 983545004557 Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes; Region: FA58C; cl12042 983545004558 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 983545004559 Coenzyme A binding pocket [chemical binding]; other site 983545004560 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 983545004561 REJ domain; Region: REJ; pfam02010 983545004562 REJ domain; Region: REJ; pfam02010 983545004563 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 983545004564 TPR motif; other site 983545004565 binding surface 983545004566 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 983545004567 binding surface 983545004568 TPR motif; other site 983545004569 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 983545004570 binding surface 983545004571 TPR motif; other site 983545004572 Protein of unknown function (DUF1330); Region: DUF1330; cl02288 983545004573 Uncharacterized subgroup of the nitrilase superfamily (putative class 13 nitrilases); Region: nitrilase_4; cd07582 983545004574 putative active site [active] 983545004575 catalytic triad [active] 983545004576 putative dimer interface [polypeptide binding]; other site 983545004577 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 983545004578 Methylomonas sp. 4,4'-diapolycopene-dialdehyde dehydrogenase-like; Region: ALDH_DDALDH; cd07099 983545004579 NAD(P) binding site [chemical binding]; other site 983545004580 catalytic residues [active] 983545004581 Sugar phosphate permease [Carbohydrate transport and metabolism]; Region: UhpC; COG2271 983545004582 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cl11420 983545004583 YCII-related domain; Region: YCII; cl00999 983545004584 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 983545004585 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 983545004586 DNA-binding site [nucleotide binding]; DNA binding site 983545004587 UTRA domain; Region: UTRA; cl01230 983545004588 MmgE/PrpD family; Region: MmgE_PrpD; cl00912 983545004589 MmgE/PrpD family; Region: MmgE_PrpD; cl00912 983545004590 Coenzyme F390 synthetase [Coenzyme metabolism]; Region: PaaK; COG1541 983545004591 AMP-binding enzyme; Region: AMP-binding; cl15778 983545004592 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 983545004593 Amidase; Region: Amidase; cl11426 983545004594 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 983545004595 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 983545004596 DNA-binding site [nucleotide binding]; DNA binding site 983545004597 UTRA domain; Region: UTRA; cl01230 983545004598 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 983545004599 FAD binding domain; Region: FAD_binding_4; pfam01565 983545004600 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 983545004601 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 983545004602 Aconitase catalytic domain; Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: Aconitase; cl00285 983545004603 substrate binding site [chemical binding]; other site 983545004604 ligand binding site [chemical binding]; other site 983545004605 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 983545004606 Aconitase swivel domain. Aconitase (aconitate hydratase) catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle. This is the aconitase swivel domain, which undergoes swivelling conformational change in the enzyme...; Region: Aconitase_swivel; cl00215 983545004607 substrate binding site [chemical binding]; other site 983545004608 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 983545004609 CoA-transferase family III; Region: CoA_transf_3; pfam02515 983545004610 3-hydroxy-3-methylglutaryl-CoA lyase, catalytic TIM barrel domain; Region: DRE_TIM_HMGL; cd07938 983545004611 active site 983545004612 catalytic residues [active] 983545004613 metal binding site [ion binding]; metal-binding site 983545004614 uncharacterized peroxidase-related enzyme; Region: peroxid_rel; TIGR01926 983545004615 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 983545004616 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 983545004617 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776 983545004618 N-terminal domain interface [polypeptide binding]; other site 983545004619 dimer interface [polypeptide binding]; other site 983545004620 substrate binding pocket (H-site) [chemical binding]; other site 983545004621 Putative NADP-dependent oxidoreductases [General function prediction only]; Region: COG2130 983545004622 Prostaglandin dehydrogenases; Region: PGDH; cd05288 983545004623 NAD(P) binding site [chemical binding]; other site 983545004624 substrate binding site [chemical binding]; other site 983545004625 dimer interface [polypeptide binding]; other site 983545004626 Type II cohesin domain, interaction partner of dockerin; Region: Type_II_cohesin; cd08547 983545004627 dockerin binding interface; other site 983545004628 PEP-CTERM motif; Region: VPEP; cl15443 983545004629 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 983545004630 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 983545004631 N-terminal plug; other site 983545004632 ligand-binding site [chemical binding]; other site 983545004633 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 983545004634 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 983545004635 enoyl-CoA hydratase; Provisional; Region: PRK06127 983545004636 substrate binding site [chemical binding]; other site 983545004637 oxyanion hole (OAH) forming residues; other site 983545004638 trimer interface [polypeptide binding]; other site 983545004639 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 983545004640 CoenzymeA binding site [chemical binding]; other site 983545004641 subunit interaction site [polypeptide binding]; other site 983545004642 PHB binding site; other site 983545004643 Protein of unknown function (DUF1838); Region: DUF1838; pfam08894 983545004644 Protein of unknown function (DUF3750); Region: DUF3750; pfam12570 983545004645 Putative catalytic domain of uncharacterized prokaryotic polysaccharide deacetylases similar to bacterial PuuE allantoinases; Region: CE4_PuuE_like; cd10979 983545004646 putative active site [active] 983545004647 putative catalytic site [active] 983545004648 Putative catalytic domain of uncharacterized prokaryotic polysaccharide deacetylases similar to bacterial PuuE allantoinases; Region: CE4_PuuE_like; cd10979 983545004649 putative urate catabolism protein; Region: uraD_N-term-dom; TIGR03212 983545004650 putative active site [active] 983545004651 putative catalytic site [active] 983545004652 Isochorismatase family; Region: Isochorismatase; pfam00857 983545004653 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cl00220 983545004654 catalytic triad [active] 983545004655 conserved cis-peptide bond; other site 983545004656 23S rRNA methyluridine methyltransferase; Reviewed; Region: rumB; PRK03522 983545004657 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 983545004658 S-adenosylmethionine binding site [chemical binding]; other site 983545004659 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl00284 983545004660 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 983545004661 YHYH protein; Region: YHYH; pfam14240 983545004662 Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279 983545004663 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 983545004664 putative acyl-acceptor binding pocket; other site 983545004665 REDY-like protein HapK; Region: HapK; pfam11639 983545004666 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 983545004667 classical (c) SDRs; Region: SDR_c; cd05233 983545004668 NAD(P) binding site [chemical binding]; other site 983545004669 active site 983545004670 putative urate catabolism protein; Region: uraD_N-term-dom; TIGR03212 983545004671 Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692 983545004672 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl09155 983545004673 FkbR2 is a Streptomyces hygroscopicus protein with a hot dog fold that belongs to a conserved family of proteins found in prokaryotes and archaea but not in eukaryotes. FkbR2 has sequence similarity to (R)-specific enoyl-CoA hydratase, the peroxisomal...; Region: FkbR2; cd03451 983545004674 putative active site [active] 983545004675 putative catalytic site [active] 983545004676 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 983545004677 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 983545004678 active site 983545004679 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 983545004680 CoA-transferase family III; Region: CoA_transf_3; pfam02515 983545004681 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 983545004682 CoA-transferase family III; Region: CoA_transf_3; pfam02515 983545004683 CpeT/CpcT family (DUF1001); Region: CpeT; pfam06206 983545004684 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 983545004685 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 983545004686 N-terminal plug; other site 983545004687 ligand-binding site [chemical binding]; other site 983545004688 bifunctional tRNA (mnm(5)s(2)U34)-methyltransferase/FAD-dependent cmnm(5)s(2)U34 oxidoreductase; Reviewed; Region: mnmC; PRK01747 983545004689 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 983545004690 Flavin containing amine oxidoreductase; Region: Amino_oxidase; pfam01593 983545004691 Membrane-bound lysozyme-inhibitor of c-type lysozyme; Region: MliC; cl01604 983545004692 Stress responsive A/B Barrel Domain; Region: Dabb; cl15807 983545004693 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 983545004694 CoenzymeA binding site [chemical binding]; other site 983545004695 subunit interaction site [polypeptide binding]; other site 983545004696 PHB binding site; other site 983545004697 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 983545004698 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 983545004699 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 983545004700 Predicted ATPase [General function prediction only]; Region: COG1485 983545004701 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 983545004702 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 983545004703 N-terminal plug; other site 983545004704 ligand-binding site [chemical binding]; other site 983545004705 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 983545004706 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 983545004707 active site 983545004708 metal binding site [ion binding]; metal-binding site 983545004709 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 983545004710 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 983545004711 ligand binding site [chemical binding]; other site 983545004712 flexible hinge region; other site 983545004713 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 983545004714 putative switch regulator; other site 983545004715 non-specific DNA interactions [nucleotide binding]; other site 983545004716 DNA binding site [nucleotide binding] 983545004717 sequence specific DNA binding site [nucleotide binding]; other site 983545004718 putative cAMP binding site [chemical binding]; other site 983545004719 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 983545004720 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 983545004721 active site 983545004722 metal binding site [ion binding]; metal-binding site 983545004723 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 983545004724 active site 983545004725 metal binding site [ion binding]; metal-binding site 983545004726 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 983545004727 Coenzyme A binding pocket [chemical binding]; other site 983545004728 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 983545004729 Sulfatase; Region: Sulfatase; cl10460 983545004730 TonB-dependent receptor; Region: TonB-Xanth-Caul; TIGR01782 983545004731 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl00284 983545004732 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl00284 983545004733 Transcriptional regulators [Transcription]; Region: FadR; COG2186 983545004734 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 983545004735 DNA-binding site [nucleotide binding]; DNA binding site 983545004736 FCD domain; Region: FCD; cl11656 983545004737 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 983545004738 Transcriptional regulators [Transcription]; Region: PurR; COG1609 983545004739 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 983545004740 DNA binding site [nucleotide binding] 983545004741 domain linker motif; other site 983545004742 Ligand-binding domain of an uncharacterized transcription regulator from Actinobacillus succinogenes and its close homologs from other bacteria; Region: PBP1_LacI_like_6; cd06284 983545004743 dimerization interface [polypeptide binding]; other site 983545004744 ligand binding site [chemical binding]; other site 983545004745 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 983545004746 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 983545004747 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 983545004748 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 983545004749 AP (apurinic/apyrimidinic) site pocket; other site 983545004750 DNA interaction; other site 983545004751 Metal-binding active site; metal-binding site 983545004752 AP endonuclease family 2 C terminus; Region: AP_endonuc_2_N; pfam07582 983545004753 Nucleoside H+ symporter; Region: Nuc_H_symport; pfam03825 983545004754 Hydroxypyruvate isomerase [Carbohydrate transport and metabolism]; Region: Hfi; COG3622 983545004755 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 983545004756 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 983545004757 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 983545004758 Gluconate 2-dehydrogenase subunit 3; Region: Gluconate_2-dh3; pfam13618 983545004759 glycosyl hydrolase family 16; Region: Glyco_hydrolase_16; cl00218 983545004760 putative transporter; Provisional; Region: PRK10484 983545004761 Sodium:solute symporter family; Region: SSF; cl00456 983545004762 Galactose mutarotase and related enzymes [Carbohydrate transport and metabolism]; Region: GalM; COG2017 983545004763 galactose mutarotase_like; Region: galactose_mutarotase_like; cd09019 983545004764 active site 983545004765 catalytic residues [active] 983545004766 DNA-binding transcriptional regulator GalR; Provisional; Region: PRK10727 983545004767 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 983545004768 DNA binding site [nucleotide binding] 983545004769 domain linker motif; other site 983545004770 Ligand binding domain of DNA transcription iso-repressor GalS, which is one of two regulatory proteins involved in galactose transport and metabolism; Region: PBP1_GalS_like; cd06270 983545004771 dimerization interface (closed form) [polypeptide binding]; other site 983545004772 ligand binding site [chemical binding]; other site 983545004773 MFS/sugar transport protein; Region: MFS_2; pfam13347 983545004774 melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392 983545004775 DNA-binding transcriptional regulator GalR; Provisional; Region: PRK10727 983545004776 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 983545004777 DNA binding site [nucleotide binding] 983545004778 Ligand binding domain of DNA transcription iso-repressor GalS, which is one of two regulatory proteins involved in galactose transport and metabolism; Region: PBP1_GalS_like; cd06270 983545004779 dimerization interface (closed form) [polypeptide binding]; other site 983545004780 ligand binding site [chemical binding]; other site 983545004781 D-cysteine desulfhydrase; Validated; Region: PRK03910 983545004782 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342 983545004783 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 983545004784 catalytic residue [active] 983545004785 Transglutaminase-like superfamily; Region: Transglut_core; cl10469 983545004786 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 983545004787 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 983545004788 metal binding site [ion binding]; metal-binding site 983545004789 active site 983545004790 I-site; other site 983545004791 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 983545004792 type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843 983545004793 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 983545004794 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 983545004795 type I secretion system ATPase, LssB family; Region: type_I_sec_LssB; TIGR03375 983545004796 A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the 'double-glycine' leader peptides from the precursors of various bacteriocins; Region: Peptidase_C39_likeD; cd02421 983545004797 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 983545004798 ABC-type bacteriocin exporters. Many non-lantibiotic bacteriocins of lactic acid bacteria are produced as precursors which have N-terminal leader peptides that share similarities in amino acid sequence and contain a conserved processing site of two...; Region: ABCC_bacteriocin_exporters; cd03245 983545004799 Walker A/P-loop; other site 983545004800 ATP binding site [chemical binding]; other site 983545004801 Q-loop/lid; other site 983545004802 ABC transporter signature motif; other site 983545004803 Walker B; other site 983545004804 D-loop; other site 983545004805 H-loop/switch region; other site 983545004806 type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844 983545004807 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 983545004808 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 983545004809 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 983545004810 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 983545004811 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 983545004812 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 983545004813 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 983545004814 Bacterial Ig-like domain (group 3); Region: Big_3_3; pfam13750 983545004815 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 983545004816 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 983545004817 Glycosyl hydrolase family 10; Region: Glyco_hydro_10; cl01495 983545004818 Transcriptional regulator [Transcription]; Region: LysR; COG0583 983545004819 Helix-turn-helix domains; Region: HTH; cl00088 983545004820 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 983545004821 dimerization interface [polypeptide binding]; other site 983545004822 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 983545004823 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 983545004824 active site 983545004825 metal binding site [ion binding]; metal-binding site 983545004826 Transcriptional regulator [Transcription]; Region: LysR; COG0583 983545004827 Helix-turn-helix domains; Region: HTH; cl00088 983545004828 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 983545004829 putative effector binding pocket; other site 983545004830 dimerization interface [polypeptide binding]; other site 983545004831 Type 1 glutamine amidotransferase (GATase1)-like domain found in proteins similar to Escherichia coli Hsp31 protein; Region: GATase1_Hsp31_like; cd03141 983545004832 Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693 983545004833 potential catalytic triad [active] 983545004834 conserved cys residue [active] 983545004835 Cobalt uptake substrate-specific transmembrane region; Region: CbiM; cl00397 983545004836 Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086 983545004837 putative phosphate binding site [ion binding]; other site 983545004838 putative catalytic site [active] 983545004839 active site 983545004840 metal binding site A [ion binding]; metal-binding site 983545004841 DNA binding site [nucleotide binding] 983545004842 putative AP binding site [nucleotide binding]; other site 983545004843 putative metal binding site B [ion binding]; other site 983545004844 Transcriptional regulators [Transcription]; Region: FadR; COG2186 983545004845 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 983545004846 DNA-binding site [nucleotide binding]; DNA binding site 983545004847 FCD domain; Region: FCD; cl11656 983545004848 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 983545004849 Mandelate racemase (MR)-like subfamily of the enolase superfamily. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved catalytic residues; Region: MR_like; cd03316 983545004850 active site pocket [active] 983545004851 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 983545004852 D-galactonate transporter; Region: 2A0114; TIGR00893 983545004853 putative substrate translocation pore; other site 983545004854 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 983545004855 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 983545004856 substrate binding site [chemical binding]; other site 983545004857 ATP binding site [chemical binding]; other site 983545004858 2-keto-3-deoxy-6-phosphogluconate aldolase [Carbohydrate transport and metabolism]; Region: Eda; COG0800 983545004859 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 983545004860 active site 983545004861 intersubunit interface [polypeptide binding]; other site 983545004862 catalytic residue [active] 983545004863 Beta-galactosidase; Region: Glyco_hydro_42; cl03154 983545004864 SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450 983545004865 Beta-galactosidase; Region: Glyco_hydro_42; cl03154 983545004866 Yhdh putative quinone oxidoreductases; Region: MDR_yhdh; cd08288 983545004867 putative quinone oxidoreductase, YhdH/YhfP family; Region: oxido_YhdH; TIGR02823 983545004868 NADP binding site [chemical binding]; other site 983545004869 dimer interface [polypeptide binding]; other site 983545004870 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 983545004871 Helix-turn-helix domains; Region: HTH; cl00088 983545004872 Arginate lyase and other MDR family members; Region: AL_MDR; cd08252 983545004873 zinc-binding alcohol dehydrogenase family protein; Region: adh_fam_1; TIGR02817 983545004874 putative NAD(P) binding site [chemical binding]; other site 983545004875 dimer interface [polypeptide binding]; other site 983545004876 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 983545004877 Glyoxalase I catalyzes the isomerization of the hemithioacetal, formed by a 2-oxoaldehyde and glutathione, to S-D-lactoylglutathione; Region: Glyoxalase_I; cd07233 983545004878 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 983545004879 dimer interface [polypeptide binding]; other site 983545004880 active site 983545004881 metal binding site [ion binding]; metal-binding site 983545004882 glutathione binding site [chemical binding]; other site 983545004883 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy; cl15773 983545004884 threonine and homoserine efflux system; Provisional; Region: PRK10532 983545004885 EamA-like transporter family; Region: EamA; cl01037 983545004886 Uncharacterized protein family (UPF0160); Region: UPF0160; cl01749 983545004887 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 983545004888 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 983545004889 active site 983545004890 Transcriptional regulator [Transcription]; Region: LysR; COG0583 983545004891 Helix-turn-helix domains; Region: HTH; cl00088 983545004892 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 983545004893 dimerization interface [polypeptide binding]; other site 983545004894 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box protein; Region: CSP_CDS; cd04458 983545004895 DNA-binding site [nucleotide binding]; DNA binding site 983545004896 RNA-binding motif; other site 983545004897 Protein of unknown function (DUF1294); Region: DUF1294; cl01311 983545004898 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 983545004899 Antibiotic biosynthesis monooxygenase; Region: ABM; cl10022 983545004900 Antibiotic biosynthesis monooxygenase; Region: ABM; cl10022 983545004901 Gluconolactonase [Carbohydrate transport and metabolism]; Region: COG3386 983545004902 Transcriptional regulator [Transcription]; Region: LysR; COG0583 983545004903 Helix-turn-helix domains; Region: HTH; cl00088 983545004904 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 983545004905 putative effector binding pocket; other site 983545004906 dimerization interface [polypeptide binding]; other site 983545004907 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: COG4667 983545004908 Hypothetical patatin similar to yjju protein of Escherichia coli; Region: Pat_hypo_Ecoli_yjju_like; cd07208 983545004909 active site 983545004910 nucleophile elbow; other site 983545004911 5-carboxymethyl-2-hydroxymuconate isomerase (CHMI) is a trimeric enzyme catalyzing the isomerization of the unsaturated ketone 5-(carboxymethyl)-2-hydroxymuconate to 5-(carboxymethyl)-2-oxo-3-hexene-1,6-dionate. This is one step in the...; Region: CHMI; cd00580 983545004912 putative substrate binding pocket [chemical binding]; other site 983545004913 trimer interface [polypeptide binding]; other site 983545004914 mttA/Hcf106 family; Region: MttA_Hcf106; cl00788 983545004915 mttA/Hcf106 family; Region: MttA_Hcf106; cl00788 983545004916 Sec-independent protein translocase protein (TatC); Region: TatC; cl00521 983545004917 TAT (twin-arginine translocation) pathway signal sequence; Region: TAT_signal; pfam10518 983545004918 Bacterial protein of unknown function (DUF839); Region: DUF839; pfam05787 983545004919 NapC/NirT cytochrome c family, N-terminal region; Region: Cytochrom_NNT; pfam03264 983545004920 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 983545004921 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 983545004922 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; cl03161 983545004923 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 983545004924 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 983545004925 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cl00159 983545004926 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 983545004927 Superfamily II DNA/RNA helicases, SNF2 family [Transcription / DNA replication, recombination, and repair]; Region: HepA; COG0553 983545004928 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 983545004929 ATP binding site [chemical binding]; other site 983545004930 putative Mg++ binding site [ion binding]; other site 983545004931 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 983545004932 nucleotide binding region [chemical binding]; other site 983545004933 ATP-binding site [chemical binding]; other site 983545004934 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 983545004935 transcriptional regulator BetI; Validated; Region: PRK00767 983545004936 Helix-turn-helix domains; Region: HTH; cl00088 983545004937 Bacterial transcriptional repressor; Region: TetR_C_6; cl07106 983545004938 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 983545004939 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 983545004940 NAD(P) binding site [chemical binding]; other site 983545004941 catalytic residues [active] 983545004942 choline dehydrogenase; Validated; Region: PRK02106 983545004943 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 983545004944 BCCT family transporter; Region: BCCT; cl00569 983545004945 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 983545004946 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl00284 983545004947 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl00284 983545004948 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383 983545004949 Predicted metal-dependent phosphoesterases (PHP family) [General function prediction only]; Region: COG0613 983545004950 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 983545004951 Iron-sulfur cluster binding domain of dihydroorotate dehydrogenase B; Region: DHODB_Fe-S_bind; pfam10418 983545004952 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 983545004953 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; cl03161 983545004954 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 983545004955 selenium-dependent molybdenum hydroxylase 1; Region: Se_dep_Molyb_1; TIGR03311 983545004956 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 983545004957 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 983545004958 DNA binding residues [nucleotide binding] 983545004959 Old yellow enzyme (OYE)-related FMN binding domain, group 2. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a reducing agent with oxygens, quinones, and alpha,beta-unsaturated aldehydes and ketones, and can act as...; Region: OYE_like_2_FMN; cd04733 983545004960 putative active site [active] 983545004961 putative FMN binding site [chemical binding]; other site 983545004962 putative substrate binding site [chemical binding]; other site 983545004963 putative catalytic residue [active] 983545004964 Major Facilitator Superfamily; Region: MFS_1; pfam07690 983545004965 Transcriptional regulator [Transcription]; Region: LysR; COG0583 983545004966 Helix-turn-helix domains; Region: HTH; cl00088 983545004967 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 983545004968 dimerization interface [polypeptide binding]; other site 983545004969 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 983545004970 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl00284 983545004971 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl00284 983545004972 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 983545004973 Sulfatase; Region: Sulfatase; cl10460 983545004974 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 983545004975 SmpB-tmRNA interface; other site 983545004976 Coenzyme Q-binding protein COQ10p and similar proteins; Region: COQ10p_like; cd07813 983545004977 putative coenzyme Q binding site [chemical binding]; other site 983545004978 The TGS domain, named after the ThrRS, GTPase, and SpoT/RelA proteins where it occurs, is structurally similar to ubiquitin. TGS is a small domain of about 50 amino acid residues with a predominantly beta-sheet structure. There is no direct information...; Region: TGS; cl15768 983545004979 Conserved hypothetical protein (DUF2461); Region: DUF2461; cl02374 983545004980 Kinase/pyrophosphorylase; Region: Kinase-PPPase; cl00780 983545004981 phosphoenolpyruvate synthase; Validated; Region: PRK06464 983545004982 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 983545004983 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; cl01586 983545004984 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl09155 983545004985 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 983545004986 FAD binding domain; Region: FAD_binding_4; pfam01565 983545004987 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 983545004988 butyryl-CoA:acetate CoA-transferase; Region: butyr_acet_CoA; TIGR03948 983545004989 Acetyl-CoA hydrolase/transferase N-terminal domain; Region: AcetylCoA_hydro; pfam02550 983545004990 SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339 983545004991 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 983545004992 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 983545004993 Histone deacetylase domain; Region: Hist_deacetyl; cl02986 983545004994 Response regulator receiver domain; Region: Response_reg; pfam00072 983545004995 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 983545004996 active site 983545004997 phosphorylation site [posttranslational modification] 983545004998 intermolecular recognition site; other site 983545004999 dimerization interface [polypeptide binding]; other site 983545005000 Putative Zn-dependent protease, contains TPR repeats [General function prediction only]; Region: COG4783 983545005001 2-octaprenyl-3-methyl-6-methoxy-1,4-benzoquinol hydroxylase; Provisional; Region: PRK08849 983545005002 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 983545005003 Bacterial protein of unknown function (DUF885); Region: DUF885; pfam05960 983545005004 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 983545005005 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 983545005006 Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548 983545005007 short chain dehydrogenase; Provisional; Region: PRK06123 983545005008 classical (c) SDRs; Region: SDR_c; cd05233 983545005009 NAD(P) binding site [chemical binding]; other site 983545005010 active site 983545005011 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 983545005012 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 983545005013 GTP-binding protein YchF; Reviewed; Region: PRK09601 983545005014 YchF GTPase; Region: YchF; cd01900 983545005015 G1 box; other site 983545005016 GTP/Mg2+ binding site [chemical binding]; other site 983545005017 Switch I region; other site 983545005018 G2 box; other site 983545005019 Switch II region; other site 983545005020 G3 box; other site 983545005021 G4 box; other site 983545005022 G5 box; other site 983545005023 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 983545005024 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 983545005025 putative active site [active] 983545005026 catalytic residue [active] 983545005027 50S ribosomal protein L25/general stress protein Ctc; Reviewed; Region: PRK05618 983545005028 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 983545005029 5S rRNA interface [nucleotide binding]; other site 983545005030 CTC domain interface [polypeptide binding]; other site 983545005031 L16 interface [polypeptide binding]; other site 983545005032 Mechanosensitive ion channel; Region: MS_channel; pfam00924 983545005033 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259 983545005034 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 983545005035 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 983545005036 active site 983545005037 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: ipk; PRK00343 983545005038 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 983545005039 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 983545005040 outer membrane lipoprotein LolB; Provisional; Region: lolB; PRK00022 983545005041 Outer membrane lipoprotein LolB; Region: LolB; pfam03550 983545005042 glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045 983545005043 NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213 983545005044 tRNA; other site 983545005045 putative tRNA binding site [nucleotide binding]; other site 983545005046 putative NADP binding site [chemical binding]; other site 983545005047 Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745 983545005048 peptide chain release factor 1; Validated; Region: prfA; PRK00591 983545005049 RF-1 domain; Region: RF-1; cl02875 983545005050 RF-1 domain; Region: RF-1; cl02875 983545005051 protein-(glutamine-N5) methyltransferase, release factor-specific; Region: RF_mod_PrmC; TIGR03534 983545005052 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 983545005053 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 983545005054 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 983545005055 active site 983545005056 phosphorylation site [posttranslational modification] 983545005057 intermolecular recognition site; other site 983545005058 dimerization interface [polypeptide binding]; other site 983545005059 Domain of unknown function (DUF3369); Region: DUF3369; pfam11849 983545005060 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 983545005061 Zn2+ binding site [ion binding]; other site 983545005062 Mg2+ binding site [ion binding]; other site 983545005063 Invasion gene expression up-regulator, SirB; Region: SirB; cl01184 983545005064 Uncharacterized conserved protein [Function unknown]; Region: COG2912 983545005065 Transglutaminase-like superfamily; Region: Transglut_core2; pfam13369 983545005066 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 983545005067 TPR motif; other site 983545005068 adenosylmethionine--8-amino-7-oxononanoate transaminase; Validated; Region: PRK07986 983545005069 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 983545005070 inhibitor-cofactor binding pocket; inhibition site 983545005071 pyridoxal 5'-phosphate binding site [chemical binding]; other site 983545005072 catalytic residue [active] 983545005073 biotin synthase; Provisional; Region: PRK15108 983545005074 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 983545005075 FeS/SAM binding site; other site 983545005076 Biotin and Thiamin Synthesis associated domain; Region: BATS; cl06149 983545005077 7-keto-8-aminopelargonate synthetase and related enzymes [Coenzyme metabolism]; Region: BioF; COG0156 983545005078 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454 983545005079 substrate-cofactor binding pocket; other site 983545005080 pyridoxal 5'-phosphate binding site [chemical binding]; other site 983545005081 catalytic residue [active] 983545005082 biotin biosynthesis protein BioC; Region: BioC; TIGR02072 983545005083 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 983545005084 S-adenosylmethionine binding site [chemical binding]; other site 983545005085 AAA domain; Region: AAA_26; pfam13500 983545005086 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 983545005087 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 983545005088 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 983545005089 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 983545005090 N-terminal plug; other site 983545005091 ligand-binding site [chemical binding]; other site 983545005092 Arginate lyase and other MDR family members; Region: AL_MDR; cd08252 983545005093 zinc-binding alcohol dehydrogenase family protein; Region: adh_fam_1; TIGR02817 983545005094 putative NAD(P) binding site [chemical binding]; other site 983545005095 dimer interface [polypeptide binding]; other site 983545005096 Major royal jelly protein; Region: MRJP; pfam03022 983545005097 Peroxiredoxin (PRX)-like 2 family; hypothetical proteins that show sequence similarity to PRXs. Members of this group contain a CXXC motif, similar to TRX. The second cysteine in the motif corresponds to the peroxidatic cysteine of PRX, however, these...; Region: PRX_like2; cd02970 983545005098 putative catalytic residues [active] 983545005099 exonuclease V subunit gamma; Provisional; Region: recC; PRK11069 983545005100 Exodeoxyribonuclease V, gamma subunit; Region: Exonuc_V_gamma; pfam04257 983545005101 exonuclease V subunit beta; Provisional; Region: recB; PRK10876 983545005102 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 983545005103 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641 983545005104 exonuclease V subunit alpha; Provisional; Region: recD; PRK10875 983545005105 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 983545005106 Family description; Region: UvrD_C_2; cl15862 983545005107 Protein of unknown function (DUF2750); Region: DUF2750; pfam11042 983545005108 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 983545005109 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 983545005110 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 983545005111 catalytic residue [active] 983545005112 Fe-S metabolism associated domain; Region: SufE; cl00951 983545005113 Isochorismatase family; Region: Isochorismatase; pfam00857 983545005114 YcaC related amidohydrolases; E.coli YcaC is an homooctameric hydrolase with unknown specificity. Despite its weak sequence similarity, it is structurally related to other amidohydrolases and shares conserved active site residues with them; Region: YcaC_related; cd01012 983545005115 catalytic triad [active] 983545005116 dimer interface [polypeptide binding]; other site 983545005117 conserved cis-peptide bond; other site 983545005118 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 983545005119 Protein of unknown function (DUF3565); Region: DUF3565; pfam12088 983545005120 Protein of unknown function (DUF3307); Region: DUF3307; pfam11750 983545005121 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 983545005122 metal binding site [ion binding]; metal-binding site 983545005123 active site 983545005124 I-site; other site 983545005125 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 983545005126 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 983545005127 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 983545005128 metal binding site [ion binding]; metal-binding site 983545005129 active site 983545005130 I-site; other site 983545005131 2-dehydropantoate 2-reductase; Provisional; Region: PRK08229 983545005132 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 983545005133 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 983545005134 Etoposide-induced protein 2.4 (EI24); Region: EI24; cl01126 983545005135 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 983545005136 Barmotin is a tight junction-associated protein expressed in rat epithelial cells which is thought to have an important regulatory role in tight junction barrier function. Barmotin belongs to the SMC protein family. SMC proteins are large; Region: ABC_SMC_barmotin; cd03278 983545005137 Walker A/P-loop; other site 983545005138 ATP binding site [chemical binding]; other site 983545005139 Q-loop/lid; other site 983545005140 Barmotin is a tight junction-associated protein expressed in rat epithelial cells which is thought to have an important regulatory role in tight junction barrier function. Barmotin belongs to the SMC protein family. SMC proteins are large; Region: ABC_SMC_barmotin; cd03278 983545005141 ABC transporter signature motif; other site 983545005142 Walker B; other site 983545005143 D-loop; other site 983545005144 H-loop/switch region; other site 983545005145 Cell division protein [Cell division and chromosome partitioning]; Region: ZipA; COG3115 983545005146 ZipA C-terminal domain. ZipA, a membrane-anchored protein, is one of at least nine essential gene products necessary for assembly of the septal ring which mediates cell division in E.coli. ZipA and FtsA directly bind FtsZ, a homolog of eukaryotic...; Region: ZipA; cl12038 983545005147 FtsZ protein binding site [polypeptide binding]; other site 983545005148 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 983545005149 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 983545005150 nucleotide binding pocket [chemical binding]; other site 983545005151 K-X-D-G motif; other site 983545005152 catalytic site [active] 983545005153 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 983545005154 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 983545005155 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 983545005156 Dimer interface [polypeptide binding]; other site 983545005157 BRCT sequence motif; other site 983545005158 Protein of unknown function (DUF3392); Region: DUF3392; pfam11872 983545005159 Uncharacterized protein conserved in bacteria (DUF2062); Region: DUF2062; cl01261 983545005160 Domain of unknown function (DUF4131); Region: DUF4131; pfam13567 983545005161 DNA internalization-related competence protein ComEC/Rec2; Region: ComEC_Rec2; TIGR00361 983545005162 Competence protein; Region: Competence; cl00471 983545005163 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 983545005164 lipid transporter ATP-binding/permease protein; Provisional; Region: PRK11176 983545005165 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 983545005166 MsbA is an essential ABC transporter, closely related to eukaryotic MDR proteins. ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars, ions, peptides, and more complex organic...; Region: ABCC_MsbA; cd03251 983545005167 Walker A/P-loop; other site 983545005168 ATP binding site [chemical binding]; other site 983545005169 Q-loop/lid; other site 983545005170 ABC transporter signature motif; other site 983545005171 Walker B; other site 983545005172 D-loop; other site 983545005173 H-loop/switch region; other site 983545005174 Tetraacyldisaccharide-1-P 4'-kinase; Region: LpxK; cl03652 983545005175 Tetraacyldisaccharide-1-P 4'-kinase [Cell envelope biogenesis, outer membrane]; Region: LpxK; COG1663 983545005176 Trm112p-like protein; Region: Trm112p; cl01066 983545005177 CMP-KDO synthetase catalyzes the activation of KDO which is an essential component of the lipopolysaccharide; Region: CMP-KDO-Synthetase; cd02517 983545005178 Ligand binding site; other site 983545005179 oligomer interface; other site 983545005180 carbonyl reductase sniffer-like, classical (c) SDRs; Region: carb_red_sniffer_like_SDR_c; cd05325 983545005181 NADP binding site [chemical binding]; other site 983545005182 homodimer interface [polypeptide binding]; other site 983545005183 active site 983545005184 D-cysteine desulfhydrase; Validated; Region: PRK03910 983545005185 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342 983545005186 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 983545005187 catalytic residue [active] 983545005188 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 983545005189 metal binding site [ion binding]; metal-binding site 983545005190 active site 983545005191 I-site; other site 983545005192 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 983545005193 Coenzyme A binding pocket [chemical binding]; other site 983545005194 Protein of unknown function (DUF2919); Region: DUF2919; pfam11143 983545005195 Transcriptional regulator [Transcription]; Region: LysR; COG0583 983545005196 Helix-turn-helix domains; Region: HTH; cl00088 983545005197 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 983545005198 dimerization interface [polypeptide binding]; other site 983545005199 sulfur acceptor protein CsdL; Provisional; Region: PRK15116 983545005200 Family of activating enzymes (E1) of ubiquitin-like proteins related to the E.coli hypothetical protein ygdL. The common reaction mechanism catalyzed by E1-like enzymes begins with a nucleophilic attack of the C-terminal carboxylate of the ubiquitin-like...; Region: YgdL_like; cd00755 983545005201 putative ATP binding site [chemical binding]; other site 983545005202 putative substrate interface [chemical binding]; other site 983545005203 GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509 983545005204 mannose-1-phosphate guanylyltransferase/mannose-6-phosphate isomerase; Region: GMP_PMI; TIGR01479 983545005205 Substrate binding site; other site 983545005206 Cupin domain; Region: Cupin_2; cl09118 983545005207 phosphomannomutase CpsG; Provisional; Region: PRK15414 983545005208 The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a...; Region: PMM_PGM; cd03089 983545005209 active site 983545005210 substrate binding site [chemical binding]; other site 983545005211 metal binding site [ion binding]; metal-binding site 983545005212 Escherichia coli (Ec) citrate synthase (CS) GltA_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). The overall CS...; Region: EcCS_like; cd06114 983545005213 dimer interface [polypeptide binding]; other site 983545005214 Citrate synthase; Region: Citrate_synt; pfam00285 983545005215 active site 983545005216 citrylCoA binding site [chemical binding]; other site 983545005217 NADH binding [chemical binding]; other site 983545005218 cationic pore residues; other site 983545005219 oxalacetate/citrate binding site [chemical binding]; other site 983545005220 coenzyme A binding site [chemical binding]; other site 983545005221 catalytic triad [active] 983545005222 Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase C (SdhC) subunit; composed of bacterial SdhC and eukaryotic large cytochrome b binding (CybL) proteins. SQR catalyzes the oxidation of succinate to fumarate coupled to the...; Region: SQR_TypeC_SdhC; cd03499 983545005223 Iron-sulfur protein interface; other site 983545005224 proximal quinone binding site [chemical binding]; other site 983545005225 SdhD (CybS) interface [polypeptide binding]; other site 983545005226 proximal heme binding site [chemical binding]; other site 983545005227 Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase D (SdhD) subunit; SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. E. coli SQR, a member of this subfamily, reduces the...; Region: SQR_TypeC_SdhD; cd03494 983545005228 SdhC subunit interface [polypeptide binding]; other site 983545005229 proximal heme binding site [chemical binding]; other site 983545005230 cardiolipin binding site; other site 983545005231 Iron-sulfur protein interface; other site 983545005232 proximal quinone binding site [chemical binding]; other site 983545005233 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK08958 983545005234 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 983545005235 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 983545005236 succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK05950 983545005237 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cl00159 983545005238 2-oxoglutarate dehydrogenase E1 component; Reviewed; Region: sucA; PRK09404 983545005239 Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016 983545005240 TPP-binding site [chemical binding]; other site 983545005241 Pyrimidine (PYR) binding domain of thiamine pyrophosphate (TPP)-dependent enzymes; Region: TPP_enzyme_PYR; cl11410 983545005242 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 983545005243 E3 interaction surface; other site 983545005244 lipoyl attachment site [posttranslational modification]; other site 983545005245 dihydrolipoamide succinyltransferase; Validated; Region: PRK05704 983545005246 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 983545005247 E3 interaction surface; other site 983545005248 lipoyl attachment site [posttranslational modification]; other site 983545005249 e3 binding domain; Region: E3_binding; pfam02817 983545005250 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; cl02008 983545005251 succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696 983545005252 ATP-grasp domain; Region: ATP-grasp_4; cl03087 983545005253 CoA-ligase; Region: Ligase_CoA; cl02894 983545005254 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 983545005255 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 983545005256 CoA-ligase; Region: Ligase_CoA; cl02894 983545005257 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506 983545005258 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 983545005259 Helix-turn-helix domains; Region: HTH; cl00088 983545005260 Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062 983545005261 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 983545005262 substrate binding pocket [chemical binding]; other site 983545005263 membrane-bound complex binding site; other site 983545005264 hinge residues; other site 983545005265 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 983545005266 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141 983545005267 Type 1 glutamine amidotransferase (GATase1)-like domain found in peptidase E; Region: GAT1_Peptidase_E; cd03146 983545005268 active site pocket [active] 983545005269 oxyanion hole [active] 983545005270 catalytic triad [active] 983545005271 active site nucleophile [active] 983545005272 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 983545005273 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl00284 983545005274 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl00284 983545005275 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 983545005276 catalytic core [active] 983545005277 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 983545005278 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 983545005279 active site 983545005280 Predicted aminoglycoside phosphotransferase [General function prediction only]; Region: COG3173 983545005281 Acyl-CoA dehydrogenase (ACAD) 10 and 11, N-terminal domain, and similar proteins. This subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: ACAD10_11_like; cd05154 983545005282 putative active site [active] 983545005283 putative substrate binding site [chemical binding]; other site 983545005284 ATP binding site [chemical binding]; other site 983545005285 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 983545005286 Quinone oxidoreductase (QOR); Region: QOR1; cd08241 983545005287 NAD(P) binding site [chemical binding]; other site 983545005288 Protein of unknown function (DUF3718); Region: DUF3718; pfam12514 983545005289 Tetratricopeptide repeat; Region: TPR_16; pfam13432 983545005290 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 983545005291 TPR motif; other site 983545005292 binding surface 983545005293 Cupin domain; Region: Cupin_2; cl09118 983545005294 Bacterial protein of unknown function (DUF924); Region: DUF924; cl01561 983545005295 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506 983545005296 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 983545005297 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 983545005298 Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714 983545005299 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 983545005300 tetramer interface [polypeptide binding]; other site 983545005301 active site 983545005302 Mg2+/Mn2+ binding site [ion binding]; other site 983545005303 Flagellin N-methylase; Region: FliB; cl00497 983545005304 renal dipeptidase (rDP), best studied in mammals and also called membrane or microsomal dipeptidase, is a membrane-bound glycoprotein hydrolyzing dipeptides and is involved in hydrolytic metabolism of penem and carbapenem beta-lactam antibiotics; Region: rDP_like; cd01301 983545005305 active site 983545005306 dimer interface [polypeptide binding]; other site 983545005307 YHYH protein; Region: YHYH; pfam14240 983545005308 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 983545005309 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl00284 983545005310 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl00284 983545005311 Transcriptional regulators [Transcription]; Region: PurR; COG1609 983545005312 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 983545005313 DNA binding site [nucleotide binding] 983545005314 domain linker motif; other site 983545005315 Ligand binding domain of a transcription regulator of cellulose genes, CelR, which is highly homologous to the LacI-GalR family of bacterial transcription regulators; Region: PBP1_CelR; cd06295 983545005316 putative dimerization interface [polypeptide binding]; other site 983545005317 putative ligand binding site [chemical binding]; other site 983545005318 Fucose permease [Carbohydrate transport and metabolism]; Region: FucP; COG0738 983545005319 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 983545005320 Bacterial alpha-L-rhamnosidase; Region: Bac_rhamnosid; cl01801 983545005321 Peptidase M14-like domain; uncharacterized subgroup; Region: M14-like_1_1; cd06238 983545005322 putative active site [active] 983545005323 Zn binding site [ion binding]; other site 983545005324 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 983545005325 conserved cys residue [active] 983545005326 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 983545005327 Predicted esterase [General function prediction only]; Region: COG0627 983545005328 class III alcohol dehydrogenases; Region: alcohol_DH_class_III; cd08300 983545005329 S-(hydroxymethyl)glutathione dehydrogenase/class III alcohol dehydrogenase; Region: adh_III_F_hyde; TIGR02818 983545005330 substrate binding site [chemical binding]; other site 983545005331 catalytic Zn binding site [ion binding]; other site 983545005332 NAD binding site [chemical binding]; other site 983545005333 structural Zn binding site [ion binding]; other site 983545005334 dimer interface [polypeptide binding]; other site 983545005335 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 983545005336 aldose dehydrogenase; Validated; Region: PRK06398 983545005337 classical (c) SDRs; Region: SDR_c; cd05233 983545005338 NAD(P) binding site [chemical binding]; other site 983545005339 active site 983545005340 Protein of unknown function (DUF2721); Region: DUF2721; pfam11026 983545005341 ribosomal protein S12 methylthiotransferase; Provisional; Region: rimO; PRK14862 983545005342 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 983545005343 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 983545005344 FeS/SAM binding site; other site 983545005345 The excision repair protein UvrA domain I; Nucleotide excision repair in eubacteria is a process that repairs DNA damage by the removal of a 12-13-mer oligonucleotide containing the lesion. Recognition and cleavage of the damaged DNA is a multistep...; Region: ABC_UvrA_I; cd03270 983545005346 The excision repair protein UvrA domain I; Nucleotide excision repair in eubacteria is a process that repairs DNA damage by the removal of a 12-13-mer oligonucleotide containing the lesion. Recognition and cleavage of the damaged DNA is a multistep...; Region: ABC_UvrA_I; cd03270 983545005347 The excision repair protein UvrA domain II; Nucleotide excision repair in eubacteria is a process that repairs DNA damage by the removal of a 12-13-mer oligonucleotide containing the lesion. Recognition and cleavage of the damaged DNA is a multistep...; Region: ABC_UvrA_II; cd03271 983545005348 Beta-agarase, member of glycosyl hydrolase family 16; Region: GH16_beta_agarase; cd02178 983545005349 calcium binding site [ion binding]; other site 983545005350 active site 983545005351 catalytic residues [active] 983545005352 TonB-dependent receptor; Region: TonB-Xanth-Caul; TIGR01782 983545005353 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl00284 983545005354 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 983545005355 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 983545005356 Sulfatase; Region: Sulfatase; cl10460 983545005357 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 983545005358 Sulfatase; Region: Sulfatase; cl10460 983545005359 Plasmid maintenance system killer protein; Region: Plasmid_killer; cl01422 983545005360 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 983545005361 sequence-specific DNA binding site [nucleotide binding]; other site 983545005362 salt bridge; other site 983545005363 Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; cl09153 983545005364 Plasmid stabilisation system protein; Region: Plasmid_stabil; cl11422 983545005365 Uncharacterized protein family (UPF0157); Region: UPF0157; cl00987 983545005366 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 983545005367 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_19; cd07262 983545005368 glycosyl hydrolase family 16; Region: Glyco_hydrolase_16; cl00218 983545005369 Domain of unknown function (DUF303); Region: DUF303; pfam03629 983545005370 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; cl08371 983545005371 Domain of unknown function (DUF303); Region: DUF303; pfam03629 983545005372 Domain of unknown function (DUF3291); Region: DUF3291; pfam11695 983545005373 YCII-related domain; Region: YCII; cl00999 983545005374 PQQ-dependent dehydrogenase, methanol/ethanol family; Region: PQQ_enz_alc_DH; TIGR03075 983545005375 Ethanol dehydrogenase, a bacterial quinoprotein (PQQ-dependent type I alcohol dehydrogenase); Region: PQQ_ADH_I; cd10277 983545005376 dimer interface [polypeptide binding]; other site 983545005377 Trp docking motif [polypeptide binding]; other site 983545005378 active site 983545005379 Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062 983545005380 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 983545005381 substrate binding pocket [chemical binding]; other site 983545005382 membrane-bound complex binding site; other site 983545005383 hinge residues; other site 983545005384 Cytochrome c; Region: Cytochrom_C; cl11414 983545005385 Periplasmic binding domain of ATP-binding cassette transporter-like systems that belong to the type I periplasmic binding fold protein superfamily; Region: PBP1_ABC_transporter_LIVBP_like; cd06268 983545005386 ligand binding site [chemical binding]; other site 983545005387 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 983545005388 PQQ-dependent catabolism-associated beta-propeller protein; Region: PQQ_ABC_repeats; TIGR03866 983545005389 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 983545005390 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 983545005391 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 983545005392 ABC transporter, ATP-binding subunit, PQQ-dependent alcohol dehydrogenase system; Region: PQQ_ABC_ATP; TIGR03864 983545005393 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 983545005394 Walker A/P-loop; other site 983545005395 ATP binding site [chemical binding]; other site 983545005396 Q-loop/lid; other site 983545005397 ABC transporter signature motif; other site 983545005398 Walker B; other site 983545005399 D-loop; other site 983545005400 H-loop/switch region; other site 983545005401 ABC-2 type transporter; Region: ABC2_membrane; cl11417 983545005402 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 983545005403 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 983545005404 N-terminal plug; other site 983545005405 ligand-binding site [chemical binding]; other site 983545005406 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 983545005407 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 983545005408 N-terminal plug; other site 983545005409 ligand-binding site [chemical binding]; other site 983545005410 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl15306 983545005411 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 983545005412 substrate binding pocket [chemical binding]; other site 983545005413 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 983545005414 dimer interface [polypeptide binding]; other site 983545005415 conserved gate region; other site 983545005416 putative PBP binding loops; other site 983545005417 ABC-ATPase subunit interface; other site 983545005418 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 983545005419 NrtD and SsuB are the ATP-binding subunits of the bacterial ABC-type nitrate and sulfonate transport systems, respectively. ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars; Region: ABC_NrtD_SsuB_transporters; cd03293 983545005420 Walker A/P-loop; other site 983545005421 ATP binding site [chemical binding]; other site 983545005422 Q-loop/lid; other site 983545005423 ABC transporter signature motif; other site 983545005424 Walker B; other site 983545005425 D-loop; other site 983545005426 H-loop/switch region; other site 983545005427 Protein of unknown function (DUF3422); Region: DUF3422; cl02073 983545005428 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl00284 983545005429 Stress responsive A/B Barrel Domain; Region: Dabb; cl15807 983545005430 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 983545005431 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 983545005432 active site 983545005433 phosphorylation site [posttranslational modification] 983545005434 intermolecular recognition site; other site 983545005435 dimerization interface [polypeptide binding]; other site 983545005436 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 983545005437 DNA binding residues [nucleotide binding] 983545005438 dimerization interface [polypeptide binding]; other site 983545005439 PAS fold; Region: PAS_7; pfam12860 983545005440 PAS fold; Region: PAS_7; pfam12860 983545005441 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 983545005442 PAS fold; Region: PAS_4; pfam08448 983545005443 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 983545005444 dimer interface [polypeptide binding]; other site 983545005445 phosphorylation site [posttranslational modification] 983545005446 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 983545005447 ATP binding site [chemical binding]; other site 983545005448 Mg2+ binding site [ion binding]; other site 983545005449 G-X-G motif; other site 983545005450 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 983545005451 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 983545005452 active site 983545005453 phosphorylation site [posttranslational modification] 983545005454 intermolecular recognition site; other site 983545005455 dimerization interface [polypeptide binding]; other site 983545005456 Uncharacterized conserved protein [Function unknown]; Region: COG3287 983545005457 FIST N domain; Region: FIST; cl10701 983545005458 FIST C domain; Region: FIST_C; pfam10442 983545005459 Regulator of nitric oxide reductase transcription [Transcription]; Region: NosR; COG3901 983545005460 FMN-binding domain; Region: FMN_bind; cl01081 983545005461 Polyferredoxin [Energy production and conversion]; Region: NapH; COG0348 983545005462 NADH dehydrogenase; Region: NADHdh; cl00469 983545005463 4Fe-4S binding domain; Region: Fer4_5; pfam12801 983545005464 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 983545005465 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 983545005466 NAD(P) binding site [chemical binding]; other site 983545005467 catalytic residues [active] 983545005468 atypical (a) SDRs, subgroup 5; Region: SDR_a5; cd05243 983545005469 NADH(P)-binding; Region: NAD_binding_10; pfam13460 983545005470 NAD(P) binding site [chemical binding]; other site 983545005471 putative active site [active] 983545005472 RaiA ('ribosome-associated inhibitor A', also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal A site; Region: RaiA; cd00552 983545005473 30S subunit binding site; other site 983545005474 leucine transcriptional activator; Reviewed; Region: leuO; PRK09508 983545005475 Helix-turn-helix domains; Region: HTH; cl00088 983545005476 The C-terminal substrate binding domain of LysR-type transcriptional regulators that involved in the catabolism of nitroaromatic/naphthalene compounds and that of related regulators; contains the type 2 periplasmic binding fold; Region: PBP2_Nitroaromatics_like; cd08417 983545005477 substrate binding pocket [chemical binding]; other site 983545005478 dimerization interface [polypeptide binding]; other site 983545005479 asparaginyl-tRNA synthetase; Validated; Region: asnC; PRK03932 983545005480 EcAsnRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli asparaginyl-tRNA synthetase (AsnRS) and, in Arabidopsis thaliana and Saccharomyces cerevisiae mitochondrial (mt) AsnRS. This domain is a beta-barrel domain (OB...; Region: EcAsnRS_like_N; cd04318 983545005481 putative dimer interface [polypeptide binding]; other site 983545005482 putative anticodon binding site; other site 983545005483 Asx tRNA synthetase (AspRS/AsnRS) class II core domain. Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776 983545005484 homodimer interface [polypeptide binding]; other site 983545005485 motif 1; other site 983545005486 motif 2; other site 983545005487 active site 983545005488 motif 3; other site 983545005489 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 983545005490 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 983545005491 dimer interface [polypeptide binding]; other site 983545005492 pyridoxal 5'-phosphate binding site [chemical binding]; other site 983545005493 catalytic residue [active] 983545005494 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 983545005495 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 983545005496 putative DNA binding site [nucleotide binding]; other site 983545005497 putative Zn2+ binding site [ion binding]; other site 983545005498 Helix-turn-helix domains; Region: HTH; cl00088 983545005499 Na+/H+ antiporter [Energy production and conversion]; Region: NhaC; COG1757 983545005500 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; cl08040 983545005501 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019 983545005502 Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cd00016 983545005503 Alkaline phosphatase homologues; Region: alkPPc; smart00098 983545005504 active site 983545005505 dimer interface [polypeptide binding]; other site 983545005506 Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cd00016 983545005507 dimer interface [polypeptide binding]; other site 983545005508 Alkaline phosphatase homologues; Region: alkPPc; smart00098 983545005509 active site 983545005510 Escherichia coli YbbF/LpxH and related proteins, metallophosphatase domain; Region: MPP_YbbF-LpxH; cd07398 983545005511 putative active site [active] 983545005512 putative metal binding site [ion binding]; other site 983545005513 peptidyl-prolyl cis-trans isomerase B (rotamase B); Provisional; Region: PRK10791 983545005514 cyclophilin_EcCYP_like: cyclophilin-type A-like peptidylprolyl cis- trans isomerase (PPIase) domain similar to the cytosolic E. coli cyclophilin A and Streptomyces antibioticus SanCyp18. Compared to the archetypal cyclophilin Human cyclophilin A, these...; Region: cyclophilin_EcCYP_like; cd01920 983545005515 substrate binding site [chemical binding]; other site 983545005516 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 983545005517 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 983545005518 active site 983545005519 HIGH motif; other site 983545005520 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 983545005521 KMSKS motif; other site 983545005522 Anticodon-binding domain of cysteinyl tRNA synthetases; Region: Anticodon_Ia_Cys; cd07963 983545005523 tRNA binding surface [nucleotide binding]; other site 983545005524 anticodon binding site; other site 983545005525 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 983545005526 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 983545005527 active site 983545005528 metal binding site [ion binding]; metal-binding site 983545005529 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic 'goose-type' lysozymes (GEWL). LTs catalyze...; Region: LT_GEWL; cd00254 983545005530 N-acetyl-D-glucosamine binding site [chemical binding]; other site 983545005531 catalytic residue [active] 983545005532 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 983545005533 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118 983545005534 putative peptidoglycan binding site; other site 983545005535 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 983545005536 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118 983545005537 putative peptidoglycan binding site; other site 983545005538 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 983545005539 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118 983545005540 putative peptidoglycan binding site; other site 983545005541 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 983545005542 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 983545005543 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 983545005544 methionyl-tRNA synthetase; Reviewed; Region: metG; PRK00133 983545005545 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 983545005546 active site 983545005547 HIGH motif; other site 983545005548 KMSKS motif; other site 983545005549 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 983545005550 tRNA binding surface [nucleotide binding]; other site 983545005551 anticodon binding site; other site 983545005552 tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins. This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties. MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800 983545005553 dimer interface [polypeptide binding]; other site 983545005554 putative tRNA-binding site [nucleotide binding]; other site 983545005555 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Mrp; COG0489 983545005556 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 983545005557 Walker A motif; other site 983545005558 2'-deoxycytidine 5'-triphosphate deaminase; Provisional; Region: PRK07559 983545005559 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 983545005560 trimer interface [polypeptide binding]; other site 983545005561 active site 983545005562 Cupin domain; Region: Cupin_2; cl09118 983545005563 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 983545005564 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 983545005565 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 983545005566 Ribosomal protein L24e/L24 is a ribosomal protein found in eukaryotes (L24) and in archaea (L24e, distinct from archaeal L24). L24e/L24 is located on the surface of the large subunit, adjacent to proteins L14 and L3, and near the translation factor...; Region: Ribosomal_L24e_L24; cl00909 983545005567 A bacterial subgroup of the C-type lectin-like (CTLD) domain; a subgroup of bacterial protein domains homologous to the carbohydrate-recognition domains (CRDs) of the C-type lectins; Region: CLECT_VCBS; cd03603 983545005568 putative transposase OrfB; Reviewed; Region: PHA02517 983545005569 HTH-like domain; Region: HTH_21; pfam13276 983545005570 Integrase core domain; Region: rve; cl01316 983545005571 Integrase core domain; Region: rve_3; cl15866 983545005572 Helix-turn-helix domains; Region: HTH; cl00088 983545005573 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 983545005574 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 983545005575 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 983545005576 catalytic residues [active] 983545005577 Bacterial protein of unknown function (DUF885); Region: DUF885; pfam05960 983545005578 Escherichia coli lactaldehyde dehydrogenase AldA-like; Region: ALDH_LactADH-AldA; cd07088 983545005579 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 983545005580 NAD binding site [chemical binding]; other site 983545005581 catalytic residues [active] 983545005582 substrate binding site [chemical binding]; other site 983545005583 2-deoxy-D-gluconate 3-dehydrogenase; Region: kduD; TIGR01832 983545005584 gluconate 5-dehydrogenase (Ga5DH)-like, classical (c) SDRs; Region: Ga5DH-like_SDR_c; cd05347 983545005585 NADP binding site [chemical binding]; other site 983545005586 homodimer interface [polypeptide binding]; other site 983545005587 active site 983545005588 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 983545005589 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 983545005590 NAD(P) binding site [chemical binding]; other site 983545005591 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 983545005592 Mandelate racemase (MR)-like subfamily of the enolase superfamily. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved catalytic residues; Region: MR_like; cd03316 983545005593 active site pocket [active] 983545005594 Transcriptional regulators [Transcription]; Region: FadR; COG2186 983545005595 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 983545005596 DNA-binding site [nucleotide binding]; DNA binding site 983545005597 FCD domain; Region: FCD; cl11656 983545005598 TonB-dependent receptor; Region: TonB-Xanth-Caul; TIGR01782 983545005599 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl00284 983545005600 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl00284 983545005601 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 983545005602 SapC; Region: SapC; pfam07277 983545005603 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 983545005604 dimer interface [polypeptide binding]; other site 983545005605 phosphorylation site [posttranslational modification] 983545005606 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 983545005607 ATP binding site [chemical binding]; other site 983545005608 Mg2+ binding site [ion binding]; other site 983545005609 G-X-G motif; other site 983545005610 Response regulator receiver domain; Region: Response_reg; pfam00072 983545005611 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 983545005612 active site 983545005613 phosphorylation site [posttranslational modification] 983545005614 intermolecular recognition site; other site 983545005615 dimerization interface [polypeptide binding]; other site 983545005616 Protein of unknown function (DUF3360); Region: DUF3360; pfam11840 983545005617 glutamine ABC transporter periplasmic protein; Reviewed; Region: glnH; PRK09495 983545005618 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 983545005619 substrate binding pocket [chemical binding]; other site 983545005620 membrane-bound complex binding site; other site 983545005621 hinge residues; other site 983545005622 multidrug efflux protein; Reviewed; Region: PRK01766 983545005623 MatE; Region: MatE; cl10513 983545005624 MatE; Region: MatE; cl10513 983545005625 molybdopterin biosynthesis protein MoeA; Provisional; Region: PRK10680 983545005626 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 983545005627 dimer interface [polypeptide binding]; other site 983545005628 putative functional site; other site 983545005629 putative MPT binding site; other site 983545005630 molybdopterin biosynthesis protein MoeB; Provisional; Region: PRK05690 983545005631 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 983545005632 ATP binding site [chemical binding]; other site 983545005633 substrate interface [chemical binding]; other site 983545005634 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3735 983545005635 TraB family; Region: TraB; cl12050 983545005636 nitrite reductase subunit NirD; Provisional; Region: PRK14989 983545005637 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; cl01093 983545005638 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 983545005639 Assimilatory nitrite reductase (NirD) family, Rieske domain; Assimilatory nitrate and nitrite reductases convert nitrate through nitrite to ammonium. Members include bacterial and fungal proteins. The bacterial NirD contains a single Rieske domain while...; Region: Rieske_NirD; cd03529 983545005640 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_Nitrate-R-NapA-like; cd02754 983545005641 formate dehydrogenase, alpha subunit, archaeal-type; Region: Fdh-alpha; TIGR01591 983545005642 [4Fe-4S] binding site [ion binding]; other site 983545005643 molybdopterin cofactor binding site; other site 983545005644 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_CT_Nitrate-R-NapA-like; cd02791 983545005645 molybdopterin cofactor binding site; other site 983545005646 NAD(P)H-nitrite reductase [Energy production and conversion]; Region: NirB; COG1251 983545005647 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; cl01093 983545005648 Precorrin-3B methylase [Coenzyme metabolism]; Region: CobJ; cl00304 983545005649 Tetrapyrrole (Corrin/Porphyrin) Methylases; Region: TP_methylase; pfam00590 983545005650 hypothetical protein; Validated; Region: PRK09071 983545005651 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 983545005652 Response regulator with putative antiterminator output domain [Signal transduction mechanisms]; Region: AmiR; COG3707 983545005653 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 983545005654 active site 983545005655 phosphorylation site [posttranslational modification] 983545005656 intermolecular recognition site; other site 983545005657 dimerization interface [polypeptide binding]; other site 983545005658 ANTAR domain; Region: ANTAR; cl04297 983545005659 NMT1-like family; Region: NMT1_2; cl15260 983545005660 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 983545005661 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 983545005662 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 983545005663 catalytic residues [active] 983545005664 dimer interface [polypeptide binding]; other site 983545005665 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506 983545005666 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 983545005667 elongation factor P; Provisional; Region: PRK04542 983545005668 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 983545005669 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 983545005670 RNA binding site [nucleotide binding]; other site 983545005671 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 983545005672 RNA binding site [nucleotide binding]; other site 983545005673 Protein of unknown function (DUF3750); Region: DUF3750; pfam12570 983545005674 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 983545005675 metal binding site [ion binding]; metal-binding site 983545005676 active site 983545005677 I-site; other site 983545005678 Gram-negative bacterial tonB protein; Region: TonB; cl10048 983545005679 Protein of unknown function (DUF3297); Region: DUF3297; pfam11730 983545005680 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 983545005681 triphenylmethane reductase (TMR)-like proteins, NMRa-like, atypical (a) SDRs; Region: TMR_SDR_a; cd05269 983545005682 NADP binding site [chemical binding]; other site 983545005683 TIGR03440 family protein; Region: unchr_TIGR03440 983545005684 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; cl15394 983545005685 probable methyltransferase; Region: TIGR03438 983545005686 Uncharacterized conserved protein (DUF2260); Region: DUF2260; pfam10017 983545005687 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_19; cd07262 983545005688 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 983545005689 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 983545005690 Protein of unknown function (DUF989); Region: DUF989; pfam06181 983545005691 Predicted membrane protein [Function unknown]; Region: COG3748 983545005692 Cytochrome c; Region: Cytochrom_C; cl11414 983545005693 guanine deaminase; Provisional; Region: PRK09228 983545005694 Guanine deaminase (GDEase). Guanine deaminase is an aminohydrolase responsible for the conversion of guanine to xanthine and ammonia, the first step to utilize guanine as a nitrogen source. This reaction also removes the guanine base from the pool and...; Region: GDEase; cd01303 983545005695 active site 983545005696 HIUase (5-hydroxyisourate hydrolase) catalyzes the second step in a three-step ureide pathway in which 5-hydroxyisourate (HIU), a product of the uricase (urate oxidase) reaction, is hydrolyzed to 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline (OHCU); Region: TLP_HIUase; cd05822 983545005697 active site 983545005698 homotetramer interface [polypeptide binding]; other site 983545005699 OHCU decarboxylase; Region: OHCU_decarbox; cl01251 983545005700 XdhC and CoxI family; Region: XdhC_CoxI; pfam02625 983545005701 xanthine dehydrogenase accessory protein XdhC; Region: xanthine_xdhC; TIGR02964 983545005702 XdhC Rossmann domain; Region: XdhC_C; pfam13478 983545005703 xanthine dehydrogenase, molybdopterin binding subunit; Region: xanthine_xdhB; TIGR02965 983545005704 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; cl03161 983545005705 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 983545005706 xanthine dehydrogenase, small subunit; Region: xanthine_xdhA; TIGR02963 983545005707 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cl00159 983545005708 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 983545005709 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; cl08390 983545005710 pyrimidine utilization regulatory protein R; Region: RutR; TIGR03613 983545005711 Helix-turn-helix domains; Region: HTH; cl00088 983545005712 YcdC-like protein, C-terminal region; Region: TetR_C_3; pfam08362 983545005713 putative urate catabolism protein; Region: uraD_N-term-dom; TIGR03212 983545005714 Catalytic domain of bacterial PuuE allantoinases, Schizosaccharomyces pombe chitin deacetylase 1 (SpCDA1), and similar proteins; Region: CE4_PuuE_SpCDA1; cd10977 983545005715 active site 983545005716 catalytic site [active] 983545005717 tetramer interface [polypeptide binding]; other site 983545005718 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 983545005719 Sulfate transporter family; Region: Sulfate_transp; cl15842 983545005720 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Add; COG1816 983545005721 Adenosine deaminase (ADA) is a monomeric zinc dependent enzyme which catalyzes the irreversible hydrolytic deamination of both adenosine, as well as desoxyadenosine, to ammonia and inosine or desoxyinosine, respectively. ADA plays an important role in...; Region: ADA; cd01320 983545005722 active site 983545005723 purine riboside binding site [chemical binding]; other site 983545005724 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 983545005725 putative substrate translocation pore; other site 983545005726 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 983545005727 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 983545005728 active site 983545005729 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 983545005730 Catalytic domain of Protein Kinases; Region: PKc; cd00180 983545005731 active site 983545005732 ATP binding site [chemical binding]; other site 983545005733 substrate binding site [chemical binding]; other site 983545005734 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 983545005735 substrate binding site [chemical binding]; other site 983545005736 activation loop (A-loop); other site 983545005737 activation loop (A-loop); other site 983545005738 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 983545005739 NMT1-like family; Region: NMT1_2; cl15260 983545005740 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 983545005741 dimer interface [polypeptide binding]; other site 983545005742 conserved gate region; other site 983545005743 putative PBP binding loops; other site 983545005744 ABC-ATPase subunit interface; other site 983545005745 NrtD and SsuB are the ATP-binding subunits of the bacterial ABC-type nitrate and sulfonate transport systems, respectively. ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars; Region: ABC_NrtD_SsuB_transporters; cd03293 983545005746 nitrate transport ATP-binding subunits C and D; Region: ntrCD; TIGR01184 983545005747 Walker A/P-loop; other site 983545005748 ATP binding site [chemical binding]; other site 983545005749 Q-loop/lid; other site 983545005750 ABC transporter signature motif; other site 983545005751 Walker B; other site 983545005752 D-loop; other site 983545005753 H-loop/switch region; other site 983545005754 Protein of unknown function (DUF541); Region: SIMPL; cl01077 983545005755 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 983545005756 Predicted membrane protein [Function unknown]; Region: COG2119 983545005757 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 983545005758 Acidobacterial duplicated orphan permease; Region: ADOP; TIGR03434 983545005759 Acidobacterial duplicated orphan permease; Region: ADOP; TIGR03434 983545005760 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 983545005761 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 983545005762 Walker A/P-loop; other site 983545005763 ATP binding site [chemical binding]; other site 983545005764 Q-loop/lid; other site 983545005765 ABC transporter signature motif; other site 983545005766 Walker B; other site 983545005767 D-loop; other site 983545005768 H-loop/switch region; other site 983545005769 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 983545005770 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 983545005771 active site 983545005772 phosphorylation site [posttranslational modification] 983545005773 intermolecular recognition site; other site 983545005774 dimerization interface [polypeptide binding]; other site 983545005775 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 983545005776 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 983545005777 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 983545005778 N-terminal plug; other site 983545005779 ligand-binding site [chemical binding]; other site 983545005780 mycofactocin system FadH/OYE family oxidoreductase 2; Region: mycofact_OYE_2; TIGR03997 983545005781 2,4-dienoyl-CoA reductase (DCR) FMN-binding domain. DCR in E. coli is an iron-sulfur flavoenzyme which contains FMN, FAD, and a 4Fe-4S cluster. It is also a monomer, unlike that of its eukaryotic counterparts which form homotetramers and lack the...; Region: DCR_FMN; cd02930 983545005782 active site 983545005783 FMN binding site [chemical binding]; other site 983545005784 2,4-decadienoyl-CoA binding site; other site 983545005785 catalytic residue [active] 983545005786 4Fe-4S cluster binding site [ion binding]; other site 983545005787 Prokaryotic dksA/traR C4-type zinc finger; Region: zf-dskA_traR; cl00755 983545005788 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 983545005789 Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538 983545005790 copper/silver efflux system membrane fusion protein CusB; Provisional; Region: PRK09783 983545005791 Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696 983545005792 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 983545005793 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD1; cd05283 983545005794 putative NAD(P) binding site [chemical binding]; other site 983545005795 putative substrate binding site [chemical binding]; other site 983545005796 catalytic Zn binding site [ion binding]; other site 983545005797 structural Zn binding site [ion binding]; other site 983545005798 dimer interface [polypeptide binding]; other site 983545005799 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Add; COG1816 983545005800 Adenosine deaminase (ADA) is a monomeric zinc dependent enzyme which catalyzes the irreversible hydrolytic deamination of both adenosine, as well as desoxyadenosine, to ammonia and inosine or desoxyinosine, respectively. ADA plays an important role in...; Region: ADA; cd01320 983545005801 active site 983545005802 purine riboside binding site [chemical binding]; other site 983545005803 Predicted protease with the C-terminal PDZ domain [General function prediction only]; Region: COG3975 983545005804 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 983545005805 protein binding site [polypeptide binding]; other site 983545005806 Protein of unknown function (DUF962); Region: DUF962; cl01879 983545005807 Putative regulator of cell autolysis [Signal transduction mechanisms]; Region: LytS; COG3275 983545005808 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 983545005809 ATP binding site [chemical binding]; other site 983545005810 Mg2+ binding site [ion binding]; other site 983545005811 G-X-G motif; other site 983545005812 putative two-component response-regulatory protein YehT; Provisional; Region: PRK11697 983545005813 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 983545005814 active site 983545005815 phosphorylation site [posttranslational modification] 983545005816 intermolecular recognition site; other site 983545005817 dimerization interface [polypeptide binding]; other site 983545005818 LytTr DNA-binding domain; Region: LytTR; cl04498 983545005819 Uncharacterized conserved protein [Function unknown]; Region: COG2850 983545005820 Adenylyl- / guanylyl cyclase, catalytic domain; Region: CYCc; smart00044 983545005821 cyclase homology domain; Region: CHD; cd07302 983545005822 nucleotidyl binding site; other site 983545005823 metal binding site [ion binding]; metal-binding site 983545005824 dimer interface [polypeptide binding]; other site 983545005825 adenylosuccinate lyase; Provisional; Region: PRK09285 983545005826 PurB_like adenylosuccinases (adenylsuccinate lyase, ASL); Region: PurB; cd01598 983545005827 tetramer interface [polypeptide binding]; other site 983545005828 active site 983545005829 Protein of unknown function (DUF489); Region: DUF489; cl01097 983545005830 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 983545005831 tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase; Region: trmU; TIGR00420 983545005832 PseudoU_synth_RluE: Pseudouridine synthase, Escherichia coli RluE. This group is comprised of bacterial proteins similar to E. coli RluE. Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines; Region: PseudoU_synth_RluE; cd02566 983545005833 pseudouridine synthase; Region: TIGR00093 983545005834 probable active site [active] 983545005835 Monomeric isocitrate dehydrogenase; Region: IDH; cl15383 983545005836 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box protein; Region: CSP_CDS; cd04458 983545005837 DNA-binding site [nucleotide binding]; DNA binding site 983545005838 RNA-binding motif; other site 983545005839 ATP-dependent Clp protease adaptor protein ClpS; Region: ClpS; cl00933 983545005840 ATP-dependent Clp protease ATP-binding subunit; Provisional; Region: clpA; PRK11034 983545005841 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 983545005842 Walker A motif; other site 983545005843 ATP binding site [chemical binding]; other site 983545005844 Walker B motif; other site 983545005845 arginine finger; other site 983545005846 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 983545005847 Walker A motif; other site 983545005848 ATP binding site [chemical binding]; other site 983545005849 Walker B motif; other site 983545005850 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; cl11083 983545005851 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 983545005852 rRNA binding site [nucleotide binding]; other site 983545005853 predicted 30S ribosome binding site; other site 983545005854 arginyl-tRNA-protein transferase; Provisional; Region: PRK01305 983545005855 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 983545005856 thioredoxin reductase; Provisional; Region: PRK10262 983545005857 Protein of unknown function, DUF412; Region: DUF412; cl01183 983545005858 hypothetical protein; Provisional; Region: PRK04860 983545005859 SprT homologues; Region: SprT; cl01182 983545005860 protease 4; Provisional; Region: PRK10949 983545005861 Signal peptide peptidase A (SppA) 67K type, a serine protease, has catalytic Ser-Lys dyad; Region: S49_SppA_67K_type; cd07018 983545005862 tandem repeat interface [polypeptide binding]; other site 983545005863 oligomer interface [polypeptide binding]; other site 983545005864 active site residues [active] 983545005865 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 983545005866 tandem repeat interface [polypeptide binding]; other site 983545005867 oligomer interface [polypeptide binding]; other site 983545005868 active site residues [active] 983545005869 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 983545005870 RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278 983545005871 RNA/DNA hybrid binding site [nucleotide binding]; other site 983545005872 active site 983545005873 DNA polymerase III, epsilon subunit, Proteobacterial; Region: dnaQ_proteo; TIGR01406 983545005874 DEDDh 3'-5' exonuclease domain of the epsilon subunit of Escherichia coli DNA polymerase III and similar proteins; Region: DNA_pol_III_epsilon_Ecoli_like; cd06131 983545005875 active site 983545005876 substrate binding site [chemical binding]; other site 983545005877 catalytic site [active] 983545005878 TIGR03503 family protein; Region: TIGR03503 983545005879 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 983545005880 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 983545005881 lipoprotein releasing system, ATP-binding protein; Region: LolD_lipo_ex; TIGR02211 983545005882 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 983545005883 Walker A/P-loop; other site 983545005884 ATP binding site [chemical binding]; other site 983545005885 Q-loop/lid; other site 983545005886 ABC transporter signature motif; other site 983545005887 Walker B; other site 983545005888 D-loop; other site 983545005889 H-loop/switch region; other site 983545005890 outer membrane-specific lipoprotein transporter subunit LolE; Provisional; Region: PRK11146 983545005891 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 983545005892 Sodium:dicarboxylate symporter family; Region: SDF; cl00573 983545005893 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383 983545005894 Succinylarginine dihydrolase; Region: AstB; cl01511 983545005895 DNA topoisomerase I subunit omega; Validated; Region: PRK07561 983545005896 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 983545005897 active site 983545005898 interdomain interaction site; other site 983545005899 putative metal-binding site [ion binding]; other site 983545005900 nucleotide binding site [chemical binding]; other site 983545005901 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 983545005902 domain I; other site 983545005903 DNA binding groove [nucleotide binding] 983545005904 phosphate binding site [ion binding]; other site 983545005905 domain II; other site 983545005906 domain III; other site 983545005907 nucleotide binding site [chemical binding]; other site 983545005908 catalytic site [active] 983545005909 domain IV; other site 983545005910 Uncharacterized protein conserved in bacteria (DUF2058); Region: DUF2058; cl01201 983545005911 CBS-domain-containing membrane protein [Signal transduction mechanisms]; Region: COG3448 983545005912 Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277 983545005913 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 983545005914 active site 983545005915 substrate binding site [chemical binding]; other site 983545005916 catalytic site [active] 983545005917 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 983545005918 Cupin domain; Region: Cupin_2; cl09118 983545005919 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 983545005920 Cyanate permease [Inorganic ion transport and metabolism]; Region: CynX; COG2807 983545005921 gamma-glutamyl-gamma-aminobutyraldehyde dehydrogenase; Provisional; Region: PRK09847 983545005922 Mycobacterium tuberculosis succinate-semialdehyde dehydrogenase 1-like; Region: ALDH_SSADH1_GabD1; cd07100 983545005923 NAD(P) binding site [chemical binding]; other site 983545005924 catalytic residues [active] 983545005925 Peptidase M1 Aminopeptidase N family incudes tricorn interacting factor F3, Endoplasmic reticulum aminopeptidase 1 (ERAP1), Aminopeptidase Q (APQ); Region: M1_APN_2; cd09601 983545005926 Aminopeptidase N [Amino acid transport and metabolism]; Region: PepN; COG0308 983545005927 Zn binding site [ion binding]; other site 983545005928 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07008 983545005929 AMP-binding enzyme; Region: AMP-binding; cl15778 983545005930 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 983545005931 classical (c) SDRs; Region: SDR_c; cd05233 983545005932 NAD(P) binding site [chemical binding]; other site 983545005933 active site 983545005934 haloalkane dehalogenase; Provisional; Region: PRK00870 983545005935 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 983545005936 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 983545005937 multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadJ; PRK11154 983545005938 substrate binding site [chemical binding]; other site 983545005939 oxyanion hole (OAH) forming residues; other site 983545005940 trimer interface [polypeptide binding]; other site 983545005941 acetyl-CoA acetyltransferase; Provisional; Region: PRK07108 983545005942 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 983545005943 dimer interface [polypeptide binding]; other site 983545005944 active site 983545005945 acyl-CoA dehydrogenase; Provisional; Region: PTZ00456 983545005946 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 983545005947 active site 983545005948 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 983545005949 Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504 983545005950 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 983545005951 metal binding site [ion binding]; metal-binding site 983545005952 active site 983545005953 I-site; other site 983545005954 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy; cl15773 983545005955 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 983545005956 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 983545005957 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 983545005958 inhibitor site; inhibition site 983545005959 active site 983545005960 dimer interface [polypeptide binding]; other site 983545005961 catalytic residue [active] 983545005962 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 983545005963 Cupin superfamily (DUF985); Region: Cupin_5; cl01418 983545005964 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 983545005965 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl00284 983545005966 hydroxydechloroatrazine ethylaminohydrolase; Reviewed; Region: PRK08203 983545005967 TRZ/ATZ family contains enzymes from the atrazine degradation pathway and related hydrolases. Atrazine, a chlorinated herbizide, can be catabolized by a variety of different bacteria. The first three steps of the atrazine dehalogenation pathway are...; Region: ATZ_TRZ_like; cd01298 983545005968 active site 983545005969 putative substrate binding pocket [chemical binding]; other site 983545005970 xanthine permease; Region: pbuX; TIGR03173 983545005971 pyrimidine utilization transport protein G; Region: RutG; TIGR03616 983545005972 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 983545005973 active site 983545005974 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 983545005975 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 983545005976 active site residue [active] 983545005977 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 983545005978 active site residue [active] 983545005979 Protein of unknown function (DUF541); Region: SIMPL; cl01077 983545005980 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859 983545005981 bifunctional proline dehydrogenase/pyrroline-5-carboxylate dehydrogenase; Reviewed; Region: PRK11905 983545005982 Proline dehydrogenase; Region: Pro_dh; cl03282 983545005983 Delta(1)-pyrroline-5-carboxylate dehydrogenase, PutA; Region: ALDH_PutA-P5CDH; cd07125 983545005984 Glutamate binding site [chemical binding]; other site 983545005985 NAD binding site [chemical binding]; other site 983545005986 catalytic residues [active] 983545005987 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 983545005988 leucine-responsive transcriptional regulator; Provisional; Region: PRK11169 983545005989 Helix-turn-helix domains; Region: HTH; cl00088 983545005990 dihydrodipicolinate reductase; Provisional; Region: PRK00048 983545005991 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 983545005992 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; cl03056 983545005993 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 983545005994 catalytic site [active] 983545005995 subunit interface [polypeptide binding]; other site 983545005996 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 983545005997 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 983545005998 IMP binding site; other site 983545005999 dimer interface [polypeptide binding]; other site 983545006000 interdomain contacts; other site 983545006001 partial ornithine binding site; other site 983545006002 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 983545006003 A type 1 glutamine amidotransferase (GATase1)-like domain found in PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_like; cd03134 983545006004 intracellular protease, PfpI family; Region: PfpI; TIGR01382 983545006005 proposed catalytic triad [active] 983545006006 conserved cys residue [active] 983545006007 putative DMT superfamily transporter inner membrane protein; Provisional; Region: PRK11272 983545006008 apolipoprotein N-acyltransferase; Reviewed; Region: lnt; PRK00302 983545006009 Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571 983545006010 putative active site [active] 983545006011 catalytic triad [active] 983545006012 putative dimer interface [polypeptide binding]; other site 983545006013 Putative Mg2+ and Co2+ transporter CorC [Inorganic ion transport and metabolism]; Region: CorC; COG4535 983545006014 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 983545006015 Transporter associated domain; Region: CorC_HlyC; cl08393 983545006016 Uncharacterized protein family UPF0054; Region: UPF0054; cl00402 983545006017 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 983545006018 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 983545006019 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14325 983545006020 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 983545006021 FeS/SAM binding site; other site 983545006022 NeuB family; Region: NeuB; cl00496 983545006023 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 983545006024 The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 983545006025 dimerization interface [polypeptide binding]; other site 983545006026 substrate binding pocket [chemical binding]; other site 983545006027 Predicted hydrolase of the alpha/beta-hydrolase fold [General function prediction only]; Region: COG3571 983545006028 Protein of unknown function (DUF423); Region: DUF423; cl01008 983545006029 putative 23S rRNA C2498 ribose 2'-O-ribose methyltransferase; Provisional; Region: PRK11760 983545006030 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl15754 983545006031 SeqA protein; Region: SeqA; cl11470 983545006032 phosphoglucomutase; Validated; Region: PRK07564 983545006033 This bacterial PGM-like (phosphoglucomutase-like) protein of unknown function belongs to the alpha-D-phosphohexomutase superfamily. The alpha-D-phosphohexomutases include several related enzymes that catalyze a reversible intramolecular phosphoryl...; Region: PGM_like3; cd05801 983545006034 active site 983545006035 substrate binding site [chemical binding]; other site 983545006036 metal binding site [ion binding]; metal-binding site 983545006037 This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300 983545006038 homodimer interface [polypeptide binding]; other site 983545006039 glycogen/starch/alpha-glucan phosphorylases; Region: P_ylase; TIGR02093 983545006040 active site pocket [active] 983545006041 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 983545006042 metal binding site [ion binding]; metal-binding site 983545006043 active site 983545006044 I-site; other site 983545006045 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 983545006046 Peptidase M14 Succinylglutamate desuccinylase (ASTE) subfamily; Region: M14_ASTE; cd03855 983545006047 putative active site [active] 983545006048 Zn binding site [ion binding]; other site 983545006049 Putative heavy-metal-binding; Region: YbjQ_1; cl00426 983545006050 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: VanY; COG1876 983545006051 succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK13009 983545006052 M20 Peptidase proteobacterial DapE encoded N-succinyl-L,L-diaminopimelic acid desuccinylase; Region: M20_DapE_proteobac; cd03891 983545006053 metal binding site [ion binding]; metal-binding site 983545006054 dimer interface [polypeptide binding]; other site 983545006055 Arsenate Reductase (ArsC) family, Yffb subfamily; Yffb is an uncharacterized bacterial protein encoded by the yffb gene, related to the thioredoxin-fold arsenic reductases, ArsC. The structure of Yffb and the conservation of the catalytic cysteine...; Region: ArsC_Yffb; cd03035 983545006056 putative catalytic residues [active] 983545006057 Rhomboid family; Region: Rhomboid; cl11446 983545006058 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 983545006059 active site 983545006060 superfamily containing globins and truncated hemoglobins; Region: globin_like; cl00280 983545006061 heme-binding site [chemical binding]; other site 983545006062 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 983545006063 metal binding site [ion binding]; metal-binding site 983545006064 active site 983545006065 I-site; other site 983545006066 GPH family sucrose/H+ symporter; Region: GPH_sucrose; TIGR01301 983545006067 Alpha amylase catalytic domain found in bacterial cyclomaltodextrinases and related proteins; Region: AmyAc_bac_CMD_like_2; cd11339 983545006068 active site 983545006069 catalytic site [active] 983545006070 Transcriptional regulators [Transcription]; Region: PurR; COG1609 983545006071 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 983545006072 DNA binding site [nucleotide binding] 983545006073 domain linker motif; other site 983545006074 Ligand binding domain of a transcription regulator of cellulose genes, CelR, which is highly homologous to the LacI-GalR family of bacterial transcription regulators; Region: PBP1_CelR; cd06295 983545006075 putative dimerization interface [polypeptide binding]; other site 983545006076 putative ligand binding site [chemical binding]; other site 983545006077 glutaminyl-tRNA synthetase; Provisional; Region: PRK05347 983545006078 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 983545006079 active site 983545006080 HIGH motif; other site 983545006081 nucleotide binding site [chemical binding]; other site 983545006082 catalytic core domain of glutaminyl-tRNA synthetase; Region: GlnRS_core; cd00807 983545006083 KMSKS motif; other site 983545006084 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 983545006085 short chain dehydrogenase; Provisional; Region: PRK08703 983545006086 NAD(P) binding site [chemical binding]; other site 983545006087 active site 983545006088 extracellular lipase, Pla-1/cef family; Region: lipase_Pla1_cef; TIGR03502 983545006089 putative inner membrane peptidase; Provisional; Region: PRK11778 983545006090 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 983545006091 tandem repeat interface [polypeptide binding]; other site 983545006092 oligomer interface [polypeptide binding]; other site 983545006093 active site residues [active] 983545006094 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 983545006095 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl00284 983545006096 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl00284 983545006097 Peptidase family M2 Angiotensin converting enzyme (ACE); Region: M2_ACE; cd06461 983545006098 active site 983545006099 Zn binding site [ion binding]; other site 983545006100 deoxyribodipyrimidine photolyase; Provisional; Region: PRK10674 983545006101 Uncharacterized conserved protein [Function unknown]; Region: COG0327 983545006102 NIF3 (NGG1p interacting factor 3); Region: NIF3; cl15371 983545006103 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 983545006104 S-adenosylmethionine binding site [chemical binding]; other site 983545006105 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 983545006106 catalytic residues [active] 983545006107 dimer interface [polypeptide binding]; other site 983545006108 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 983545006109 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 983545006110 Uncharacterized conserved protein [Function unknown]; Region: COG1315 983545006111 exonuclease I; Provisional; Region: sbcB; PRK11779 983545006112 N-terminal DEDDh 3'-5' exonuclease domain of Escherichia coli exonuclease I and similar proteins; Region: ExoI_N; cd06138 983545006113 active site 983545006114 substrate binding site [chemical binding]; other site 983545006115 catalytic site [active] 983545006116 FOG: CBS domain [General function prediction only]; Region: COG0517 983545006117 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_16; cd04629 983545006118 ATP-dependent RNA helicase HrpA; Provisional; Region: PRK11131 983545006119 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 983545006120 ATP binding site [chemical binding]; other site 983545006121 putative Mg++ binding site [ion binding]; other site 983545006122 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 983545006123 nucleotide binding region [chemical binding]; other site 983545006124 ATP-binding site [chemical binding]; other site 983545006125 Helicase associated domain (HA2); Region: HA2; cl04503 983545006126 23S rRNA m(5)C1962 methyltransferase; Provisional; Region: PRK15128 983545006127 PUA domain; Region: PUA; cl00607 983545006128 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 983545006129 S-adenosylmethionine binding site [chemical binding]; other site 983545006130 putative NAD(P)H quinone oxidoreductase, PIG3 family; Region: quinone_pig3; TIGR02824 983545006131 PIG3 p53-inducible quinone oxidoreductase; Region: p53_inducible_oxidoreductase; cd05276 983545006132 NAD(P) binding site [chemical binding]; other site 983545006133 EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to...; Region: EFh; cl08302 983545006134 pseudo EF-hand loop; other site 983545006135 peptide binding pocket; other site 983545006136 Ca2+ binding site [ion binding]; other site 983545006137 Alpha amylase catalytic domain found in sucrose phosphorylase-like proteins (also called sucrose glucosyltransferase, disaccharide glucosyltransferase, and sucrose-phosphate alpha-D glucosyltransferase); Region: AmyAc_Sucrose_phosphorylase-like_1; cd11356 983545006138 active site 983545006139 homodimer interface [polypeptide binding]; other site 983545006140 catalytic site [active] 983545006141 putative glucosyl-3-phosphoglycerate synthase; Provisional; Region: PRK13915 983545006142 mannosyl-3-phosphoglycerate phosphatase; Reviewed; Region: PRK00192 983545006143 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 983545006144 active site 983545006145 motif I; other site 983545006146 motif II; other site 983545006147 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 983545006148 D-glycerate 3-kinase; Region: PLN02796 983545006149 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 983545006150 active site 983545006151 molybdenum cofactor biosynthesis protein A; Reviewed; Region: moaA; PRK00164 983545006152 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 983545006153 FeS/SAM binding site; other site 983545006154 molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317 983545006155 MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503 983545006156 GTP binding site; other site 983545006157 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 983545006158 MPT binding site; other site 983545006159 trimer interface [polypeptide binding]; other site 983545006160 MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420 983545006161 trimer interface [polypeptide binding]; other site 983545006162 dimer interface [polypeptide binding]; other site 983545006163 putative active site [active] 983545006164 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 983545006165 MoaE interaction surface [polypeptide binding]; other site 983545006166 MoeB interaction surface [polypeptide binding]; other site 983545006167 thiocarboxylated glycine; other site 983545006168 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 983545006169 MoaE homodimer interface [polypeptide binding]; other site 983545006170 MoaD interaction [polypeptide binding]; other site 983545006171 active site residues [active] 983545006172 ABC-type molybdate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: ModA; COG0725 983545006173 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 983545006174 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 983545006175 dimer interface [polypeptide binding]; other site 983545006176 conserved gate region; other site 983545006177 putative PBP binding loops; other site 983545006178 ABC-ATPase subunit interface; other site 983545006179 ferric uptake regulator; Provisional; Region: fur; PRK09462 983545006180 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 983545006181 metal binding site 2 [ion binding]; metal-binding site 983545006182 putative DNA binding helix; other site 983545006183 metal binding site 1 [ion binding]; metal-binding site 983545006184 dimer interface [polypeptide binding]; other site 983545006185 structural Zn2+ binding site [ion binding]; other site 983545006186 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 983545006187 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4782 983545006188 acyl-CoA esterase; Provisional; Region: PRK10673 983545006189 Domain in histone-like proteins of HNS family; Region: HNS; cl09251 983545006190 DNA binding protein, nucleoid-associated; Provisional; Region: PRK10328 983545006191 Dehydrogenases (flavoproteins) [Energy production and conversion]; Region: FixC; COG0644 983545006192 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 983545006193 Ferredoxin-like protein [Energy production and conversion]; Region: FixX; COG2440 983545006194 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 983545006195 Ligand binding site [chemical binding]; other site 983545006196 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715 983545006197 electron transfer flavoprotein subunit alpha; Provisional; Region: PLN00022 983545006198 Beta-galactosidase [Carbohydrate transport and metabolism]; Region: LacA; COG1874 983545006199 A4 beta-galactosidase middle domain: a type 1 glutamine amidotransferase (GATase1)-like domain; Region: A4_beta-galactosidase_middle_domain; cd03143 983545006200 N-terminal Early set domain associated with the catalytic domain of isoamylase-like (also called glycogen 6-glucanohydrolase) proteins; Region: E_set_Isoamylase_like_N; cd07184 983545006201 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 983545006202 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_2; cd03138 983545006203 conserved cys residue [active] 983545006204 acyl-CoA dehydrogenase; Provisional; Region: PTZ00456 983545006205 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 983545006206 active site 983545006207 Prostaglandin dehydrogenases; Region: PGDH; cd05288 983545006208 Putative NADP-dependent oxidoreductases [General function prediction only]; Region: COG2130 983545006209 NAD(P) binding site [chemical binding]; other site 983545006210 substrate binding site [chemical binding]; other site 983545006211 dimer interface [polypeptide binding]; other site 983545006212 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 983545006213 classical (c) SDRs; Region: SDR_c; cd05233 983545006214 NAD(P) binding site [chemical binding]; other site 983545006215 active site 983545006216 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 983545006217 classical (c) SDRs; Region: SDR_c; cd05233 983545006218 NAD(P) binding site [chemical binding]; other site 983545006219 active site 983545006220 Protein of unknown function (DUF1318); Region: DUF1318; cl01547 983545006221 3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK06519 983545006222 Dicarboxylate transport; Region: DctA-YdbH; cl14674 983545006223 ATP-dependent RNA helicase RhlE; Provisional; Region: PRK10590 983545006224 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 983545006225 ATP binding site [chemical binding]; other site 983545006226 Mg++ binding site [ion binding]; other site 983545006227 motif III; other site 983545006228 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 983545006229 nucleotide binding region [chemical binding]; other site 983545006230 ATP-binding site [chemical binding]; other site 983545006231 ribonuclease E; Reviewed; Region: rne; PRK10811 983545006232 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 983545006233 homodimer interface [polypeptide binding]; other site 983545006234 oligonucleotide binding site [chemical binding]; other site 983545006235 23S rRNA pseudouridylate synthase C; Provisional; Region: PRK11025 983545006236 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 983545006237 RNA binding surface [nucleotide binding]; other site 983545006238 PseudoU_synth_RsuA/RluD: Pseudouridine synthase, RsuA/RluD family. This group is comprised of eukaryotic, bacterial and archeal proteins similar to eight site specific Escherichia coli pseudouridine synthases: RsuA, RluA, RluB, RluC, RluD, RluE, RluF and...; Region: PseudoU_synth_RluCD_like; cd02869 983545006239 active site 983545006240 dTDP-glucose 4,6 dehydratase; Provisional; Region: PRK10084 983545006241 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 983545006242 NAD binding site [chemical binding]; other site 983545006243 substrate binding site [chemical binding]; other site 983545006244 homodimer interface [polypeptide binding]; other site 983545006245 active site 983545006246 glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207 983545006247 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538 983545006248 substrate binding site; other site 983545006249 tetramer interface; other site 983545006250 Cupin domain; Region: Cupin_2; cl09118 983545006251 dTDP-4-dehydrorhamnose reductase; Region: rmlD; TIGR01214 983545006252 dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254 983545006253 NADP binding site [chemical binding]; other site 983545006254 active site 983545006255 putative substrate binding site [chemical binding]; other site 983545006256 Maf-like protein; Provisional; Region: PRK14361 983545006257 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 983545006258 active site 983545006259 dimer interface [polypeptide binding]; other site 983545006260 Uncharacterized ACR, COG1399; Region: DUF177; cl00616 983545006261 Ribosomal L32p protein family; Region: Ribosomal_L32p; cl09115 983545006262 Phosphate acetyl/butaryl transferase; Region: PTA_PTB; cl00390 983545006263 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 983545006264 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 983545006265 dimer interface [polypeptide binding]; other site 983545006266 active site 983545006267 CoA binding pocket [chemical binding]; other site 983545006268 Acyl transferase domain; Region: Acyl_transf_1; cl08282 983545006269 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 983545006270 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 983545006271 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 983545006272 NAD(P) binding site [chemical binding]; other site 983545006273 homotetramer interface [polypeptide binding]; other site 983545006274 homodimer interface [polypeptide binding]; other site 983545006275 active site 983545006276 Phosphopantetheine attachment site; Region: PP-binding; cl09936 983545006277 3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK07314 983545006278 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 983545006279 dimer interface [polypeptide binding]; other site 983545006280 active site 983545006281 ADCL_like: 4-Amino-4-deoxychorismate lyase: is a member of the fold-type IV of PLP dependent enzymes that converts 4-amino-4-deoxychorismate (ADC) to p-aminobenzoate and pyruvate. Based on the information available from the crystal structure, most...; Region: ADCL_like; cd01559 983545006282 pyridoxal 5'-phosphate binding site [chemical binding]; other site 983545006283 catalytic residue [active] 983545006284 proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010 983545006285 dimerization interface [polypeptide binding]; other site 983545006286 thymidylate kinase; Validated; Region: tmk; PRK00698 983545006287 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 983545006288 TMP-binding site; other site 983545006289 ATP-binding site [chemical binding]; other site 983545006290 DNA polymerase III, delta' subunit; Region: holB; TIGR00678 983545006291 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 983545006292 Walker A motif; other site 983545006293 ATP binding site [chemical binding]; other site 983545006294 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 983545006295 Walker B motif; other site 983545006296 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 983545006297 active site 983545006298 N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855 983545006299 malto-oligosyltrehalose trehalohydrolase; Region: trehalose_TreZ; TIGR02402 983545006300 Alpha amylase catalytic domain found in Glycosyltrehalose trehalohydrolase (also called Maltooligosyl trehalose Trehalohydrolase); Region: AmyAc_GTHase; cd11325 983545006301 catalytic site [active] 983545006302 active site 983545006303 membrane-bound PQQ-dependent dehydrogenase, glucose/quinate/shikimate family; Region: PQQ_membr_DH; TIGR03074 983545006304 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 983545006305 Membrane-bound PQQ-dependent glucose dehydrogenase; Region: PQQ_mGDH; cd10280 983545006306 Trp docking motif [polypeptide binding]; other site 983545006307 putative active site [active] 983545006308 INT_SG1, DNA breaking-rejoining enzymes, integrase/recombinases subgroup 1, C-terminal catalytic domain. The CD contains mainly predicted integrase/recombinase and site-specific XerD recombinases. The members of this CD are found predominantly in...; Region: INT_SG1_C; cd01183 983545006309 Int/Topo IB signature motif; other site 983545006310 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 983545006311 6-phosphogluconate dehydrogenase; Validated; Region: PRK09287 983545006312 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 983545006313 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 983545006314 catalytic residues [active] 983545006315 putative transposase OrfB; Reviewed; Region: PHA02517 983545006316 Spore germination protein; Region: Spore_permease; cl15802 983545006317 Predicted transporter component [General function prediction only]; Region: COG2391 983545006318 Predicted transporter component [General function prediction only]; Region: COG2391 983545006319 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 983545006320 dimerization interface [polypeptide binding]; other site 983545006321 putative DNA binding site [nucleotide binding]; other site 983545006322 putative Zn2+ binding site [ion binding]; other site 983545006323 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 983545006324 putative active site [active] 983545006325 heme pocket [chemical binding]; other site 983545006326 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 983545006327 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 983545006328 dimer interface [polypeptide binding]; other site 983545006329 phosphorylation site [posttranslational modification] 983545006330 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 983545006331 ATP binding site [chemical binding]; other site 983545006332 Mg2+ binding site [ion binding]; other site 983545006333 G-X-G motif; other site 983545006334 chemotaxis regulatory protein CheY; Provisional; Region: PRK10610 983545006335 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 983545006336 active site 983545006337 phosphorylation site [posttranslational modification] 983545006338 intermolecular recognition site; other site 983545006339 dimerization interface [polypeptide binding]; other site 983545006340 universal stress protein UspE; Provisional; Region: PRK11175 983545006341 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 983545006342 Ligand Binding Site [chemical binding]; other site 983545006343 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 983545006344 Ligand Binding Site [chemical binding]; other site 983545006345 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 983545006346 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 983545006347 putative active site [active] 983545006348 heme pocket [chemical binding]; other site 983545006349 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 983545006350 dimer interface [polypeptide binding]; other site 983545006351 phosphorylation site [posttranslational modification] 983545006352 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 983545006353 ATP binding site [chemical binding]; other site 983545006354 Mg2+ binding site [ion binding]; other site 983545006355 G-X-G motif; other site 983545006356 response regulator FixJ; Provisional; Region: fixJ; PRK09390 983545006357 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 983545006358 active site 983545006359 phosphorylation site [posttranslational modification] 983545006360 intermolecular recognition site; other site 983545006361 dimerization interface [polypeptide binding]; other site 983545006362 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 983545006363 DNA binding residues [nucleotide binding] 983545006364 dimerization interface [polypeptide binding]; other site 983545006365 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 983545006366 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 983545006367 active site 983545006368 phosphorylation site [posttranslational modification] 983545006369 intermolecular recognition site; other site 983545006370 dimerization interface [polypeptide binding]; other site 983545006371 Plastocyanin domain containing protein [General function prediction only]; Region: COG4633 983545006372 copper exporting ATPase; Provisional; Region: copA; PRK10671 983545006373 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 983545006374 metal-binding site [ion binding] 983545006375 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 983545006376 Helix-Turn-Helix DNA binding domain of putative Heavy Metal Resistance transcription regulators; Region: HTH_HMRTR_unk; cd04787 983545006377 DNA binding residues [nucleotide binding] 983545006378 zinc-responsive transcriptional regulator; Provisional; Region: zntR; PRK09514 983545006379 dimer interface [polypeptide binding]; other site 983545006380 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 983545006381 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 983545006382 active site 983545006383 phosphorylation site [posttranslational modification] 983545006384 intermolecular recognition site; other site 983545006385 dimerization interface [polypeptide binding]; other site 983545006386 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 983545006387 metal binding site [ion binding]; metal-binding site 983545006388 active site 983545006389 I-site; other site 983545006390 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 983545006391 Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to PFK family that includes ATP- and pyrophosphate (PPi)- dependent phosphofructokinases; Region: PFK; cl00204 983545006392 active site 983545006393 ADP/pyrophosphate binding site [chemical binding]; other site 983545006394 dimerization interface [polypeptide binding]; other site 983545006395 allosteric effector site; other site 983545006396 fructose-1,6-bisphosphate binding site; other site 983545006397 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 983545006398 active site residue [active] 983545006399 fumarate/nitrate reduction transcriptional regulator; Provisional; Region: PRK11161 983545006400 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 983545006401 ligand binding site [chemical binding]; other site 983545006402 flexible hinge region; other site 983545006403 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 983545006404 putative switch regulator; other site 983545006405 non-specific DNA interactions [nucleotide binding]; other site 983545006406 DNA binding site [nucleotide binding] 983545006407 sequence specific DNA binding site [nucleotide binding]; other site 983545006408 putative cAMP binding site [chemical binding]; other site 983545006409 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 983545006410 dimer interface [polypeptide binding]; other site 983545006411 phosphorylation site [posttranslational modification] 983545006412 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 983545006413 ATP binding site [chemical binding]; other site 983545006414 Mg2+ binding site [ion binding]; other site 983545006415 G-X-G motif; other site 983545006416 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 983545006417 active site 983545006418 phosphorylation site [posttranslational modification] 983545006419 intermolecular recognition site; other site 983545006420 dimerization interface [polypeptide binding]; other site 983545006421 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 983545006422 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 983545006423 active site 983545006424 phosphorylation site [posttranslational modification] 983545006425 intermolecular recognition site; other site 983545006426 dimerization interface [polypeptide binding]; other site 983545006427 The outer membrane phospholipase A (OMPLA) is an integral membrane enzyme that catalyses the hydrolysis of acylester bonds in phospholipids using calcium as a cofactor. The enzyme has a fold of transmembrane beta-barrels and is widespread among...; Region: OMPLA; cd00541 983545006428 dimerization interface [polypeptide binding]; other site 983545006429 substrate binding site [chemical binding]; other site 983545006430 active site 983545006431 calcium binding site [ion binding]; other site 983545006432 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 983545006433 ligand binding site [chemical binding]; other site 983545006434 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 983545006435 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 983545006436 DNA binding residues [nucleotide binding] 983545006437 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 983545006438 Bacterioferritin (cytochrome b1) [Inorganic ion transport and metabolism]; Region: Bfr; COG2193 983545006439 Bacterioferritin, ferritin-like diiron-binding domain; Region: Bacterioferritin; cd00907 983545006440 heme binding site [chemical binding]; other site 983545006441 ferroxidase pore; other site 983545006442 ferroxidase diiron center [ion binding]; other site 983545006443 Bacterioferritin (cytochrome b1) [Inorganic ion transport and metabolism]; Region: Bfr; COG2193 983545006444 Bacterioferritin, ferritin-like diiron-binding domain; Region: Bacterioferritin; cd00907 983545006445 heme binding site [chemical binding]; other site 983545006446 ferroxidase pore; other site 983545006447 ferroxidase diiron center [ion binding]; other site 983545006448 Cytochrome cbb3 oxidase subunit I. Cytochrome cbb3 oxidase, the terminal oxidase in the respiratory chains of proteobacteria, is a multi-chain transmembrane protein located in the cell membrane. Like other cytochrome oxidases, it catalyzes the reduction...; Region: cbb3_Oxidase_I; cd01661 983545006449 Low-spin heme binding site [chemical binding]; other site 983545006450 Putative water exit pathway; other site 983545006451 Binuclear center (active site) [active] 983545006452 Putative proton exit pathway; other site 983545006453 Cbb3-type cytochrome oxidase, cytochrome c subunit [Energy production and conversion]; Region: CcoO; COG2993 983545006454 Cytochrome C oxidase, mono-heme subunit/FixO; Region: FixO; cl01130 983545006455 Cytochrome cbb oxidase CcoQ. Cytochrome cbb3 oxidase, the terminal oxidase in the respiratory chains of proteobacteria, is a multi-chain transmembrane protein located in the cell membrane. Like other cytochrome oxidases, it catalyzes the reduction of O2...; Region: cbb3_Oxidase_CcoQ; cl00282 983545006456 Succinate:quinone oxidoreductase (SQR) and Quinol:fumarate reductase (QFR) family, transmembrane subunits; SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol, while QFR catalyzes the reverse reaction. SQR; Region: SQR_QFR_TM; cl00881 983545006457 Iron-sulfur protein interface; other site 983545006458 proximal heme binding site [chemical binding]; other site 983545006459 cytochrome c oxidase, cbb3-type, subunit III; Region: ccoP; TIGR00782 983545006460 Cytochrome c; Region: Cytochrom_C; cl11414 983545006461 Cytochrome c; Region: Cytochrom_C; cl11414 983545006462 FixH; Region: FixH; cl01254 983545006463 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 983545006464 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 983545006465 metal-binding site [ion binding] 983545006466 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 983545006467 Cytochrome oxidase maturation protein cbb3-type; Region: CcoS; cl01253 983545006468 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 983545006469 universal stress protein UspE; Provisional; Region: PRK11175 983545006470 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 983545006471 Ligand Binding Site [chemical binding]; other site 983545006472 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 983545006473 Ligand Binding Site [chemical binding]; other site 983545006474 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 983545006475 phosphate ABC transporter, ATP-binding protein; Region: 3a0107s01c2; TIGR00972 983545006476 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 983545006477 Walker A/P-loop; other site 983545006478 ATP binding site [chemical binding]; other site 983545006479 Q-loop/lid; other site 983545006480 ABC transporter signature motif; other site 983545006481 Walker B; other site 983545006482 D-loop; other site 983545006483 H-loop/switch region; other site 983545006484 tRNA 2-thiocytidine biosynthesis protein TtcA; Provisional; Region: PRK10696 983545006485 This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which binds to Adenosine group. This subfamily; Region: Alpha_ANH_like_II; cd01993 983545006486 Ligand Binding Site [chemical binding]; other site 983545006487 hypothetical protein; Provisional; Region: PRK10279 983545006488 Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396 983545006489 active site 983545006490 nucleophile elbow; other site 983545006491 lysozyme_like domain. This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222 983545006492 LysE type translocator; Region: LysE; cl00565 983545006493 NAD-dependent deacetylase; Provisional; Region: PRK00481 983545006494 SIRT5_Af1_CobB: Eukaryotic, archaeal and prokaryotic group (class3) which includes human sirtuin SIRT5, Archaeoglobus fulgidus Sir2-Af1, and E. coli CobB; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which...; Region: SIRT5_Af1_CobB; cd01412 983545006495 NAD+ binding site [chemical binding]; other site 983545006496 substrate binding site [chemical binding]; other site 983545006497 Zn binding site [ion binding]; other site 983545006498 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 983545006499 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 983545006500 putative active site [active] 983545006501 fumarate hydratase; Reviewed; Region: fumC; PRK00485 983545006502 Class II fumarases; Region: Fumarase_classII; cd01362 983545006503 active site 983545006504 tetramer interface [polypeptide binding]; other site 983545006505 Amidase; Region: Amidase; cl11426 983545006506 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; cl08040 983545006507 gamma-glutamyltranspeptidase; Region: g_glut_trans; TIGR00066 983545006508 Predicted permeases [General function prediction only]; Region: COG0730; cl00498 983545006509 Serine-pyruvate aminotransferase/archaeal aspartate aminotransferase [Amino acid transport and metabolism]; Region: COG0075 983545006510 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 983545006511 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 983545006512 catalytic residue [active] 983545006513 allantoate amidohydrolase; Reviewed; Region: PRK09290 983545006514 M20 Peptidase beta-alanine synthase, an amidohydrolase; Region: M20_bAS; cd03884 983545006515 active site 983545006516 metal binding site [ion binding]; metal-binding site 983545006517 dimer interface [polypeptide binding]; other site 983545006518 Cupin domain; Region: Cupin_2; cl09118 983545006519 Flavin Reductases; Region: FlaRed; cl00801 983545006520 Glutaminase; Region: Glutaminase; cl00907 983545006521 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 983545006522 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 983545006523 putative molybdenum transport ATP-binding protein ModF; Provisional; Region: PRK10938 983545006524 Walker A/P-loop; other site 983545006525 ATP binding site [chemical binding]; other site 983545006526 Q-loop/lid; other site 983545006527 ABC transporter signature motif; other site 983545006528 Walker B; other site 983545006529 D-loop; other site 983545006530 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 983545006531 Walker A/P-loop; other site 983545006532 ATP binding site [chemical binding]; other site 983545006533 Q-loop/lid; other site 983545006534 ABC transporter signature motif; other site 983545006535 Walker B; other site 983545006536 D-loop; other site 983545006537 H-loop/switch region; other site 983545006538 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 983545006539 Helix-turn-helix domains; Region: HTH; cl00088 983545006540 Serine-pyruvate aminotransferase/archaeal aspartate aminotransferase [Amino acid transport and metabolism]; Region: COG0075 983545006541 Alanine-glyoxylate aminotransferase (AGAT) family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to alanine-glyoxylate aminotransferase (AGAT); Region: AGAT_like; cd06451 983545006542 homodimer interface [polypeptide binding]; other site 983545006543 pyridoxal 5'-phosphate binding site [chemical binding]; other site 983545006544 catalytic residue [active] 983545006545 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 983545006546 Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645 983545006547 trimer interface [polypeptide binding]; other site 983545006548 putative metal binding site [ion binding]; other site 983545006549 acyl-CoA thioesterase II; Provisional; Region: PRK10526 983545006550 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat2; cd03445 983545006551 active site 983545006552 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat1; cd03444 983545006553 catalytic triad [active] 983545006554 dimer interface [polypeptide binding]; other site 983545006555 Catalytic domain of Protein Kinases; Region: PKc; cd00180 983545006556 active site 983545006557 ATP binding site [chemical binding]; other site 983545006558 substrate binding site [chemical binding]; other site 983545006559 activation loop (A-loop); other site 983545006560 Protein involved in catabolism of external DNA [General function prediction only]; Region: ComJ; COG2961 983545006561 dihydrolipoamide acetyltransferase; Reviewed; Region: PRK11855 983545006562 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 983545006563 E3 interaction surface; other site 983545006564 lipoyl attachment site [posttranslational modification]; other site 983545006565 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 983545006566 E3 interaction surface; other site 983545006567 lipoyl attachment site [posttranslational modification]; other site 983545006568 3-methyl-2-oxobutanate dehydrogenase; Provisional; Region: PTZ00182 983545006569 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 983545006570 alpha subunit interface [polypeptide binding]; other site 983545006571 TPP binding site [chemical binding]; other site 983545006572 heterodimer interface [polypeptide binding]; other site 983545006573 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_x; TIGR03181 983545006574 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 983545006575 tetramer interface [polypeptide binding]; other site 983545006576 TPP-binding site [chemical binding]; other site 983545006577 heterodimer interface [polypeptide binding]; other site 983545006578 phosphorylation loop region [posttranslational modification] 983545006579 Predicted integral membrane protein (DUF2189); Region: DUF2189; cl02291 983545006580 Aspartate/tyrosine/aromatic aminotransferase [Amino acid transport and metabolism]; Region: COG0436 983545006581 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 983545006582 pyridoxal 5'-phosphate binding site [chemical binding]; other site 983545006583 homodimer interface [polypeptide binding]; other site 983545006584 catalytic residue [active] 983545006585 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 983545006586 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 983545006587 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 983545006588 NAD(P) binding site [chemical binding]; other site 983545006589 active site 983545006590 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 983545006591 deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional; Region: PRK05318 983545006592 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 983545006593 TMAO/DMSO reductase; Reviewed; Region: PRK05363 983545006594 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 983545006595 Moco binding site; other site 983545006596 metal coordination site [ion binding]; other site 983545006597 Ferric reductase like transmembrane component; Region: Ferric_reduct; cl01043 983545006598 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3012 983545006599 FabA, beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase: Bacterial protein of the type II, fatty acid synthase system that binds ACP and catalyzes both dehydration and isomerization reactions, apparently in the same active site. The FabA...; Region: FabA; cd01287 983545006600 active site 1 [active] 983545006601 dimer interface [polypeptide binding]; other site 983545006602 active site 2 [active] 983545006603 Ribosome modulation factor; Region: RMF; cl01207 983545006604 ABC transporter ATPase component; Reviewed; Region: PRK11147 983545006605 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 983545006606 Walker A/P-loop; other site 983545006607 ATP binding site [chemical binding]; other site 983545006608 Q-loop/lid; other site 983545006609 ABC transporter signature motif; other site 983545006610 Walker B; other site 983545006611 D-loop; other site 983545006612 H-loop/switch region; other site 983545006613 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 983545006614 23S rRNA m(2)G2445 methyltransferase; Provisional; Region: rlmL; PRK11783 983545006615 THUMP domain; Region: THUMP; cl12076 983545006616 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 983545006617 S-adenosylmethionine binding site [chemical binding]; other site 983545006618 Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738 983545006619 quinone interaction residues [chemical binding]; other site 983545006620 Dihydroorotate dehydrogenase [Nucleotide transport and metabolism]; Region: PyrD; COG0167 983545006621 active site 983545006622 catalytic residues [active] 983545006623 FMN binding site [chemical binding]; other site 983545006624 substrate binding site [chemical binding]; other site 983545006625 NAD-specific glutamate dehydrogenase [Amino acid transport and metabolism]; Region: COG2902 983545006626 Predicted exporters of the RND superfamily [General function prediction only]; Region: COG1033 983545006627 Uncharacterized protein related to plant photosystem II stability/assembly factor [General function prediction only]; Region: COG4447 983545006628 Protein of unknown function (DUF2835); Region: DUF2835; pfam11197 983545006629 aminopeptidase N; Provisional; Region: pepN; PRK14015 983545006630 Peptidase M1 family containing Aminopeptidase N; Region: M1_APN_1; cd09600 983545006631 active site 983545006632 Zn binding site [ion binding]; other site 983545006633 Na+/H+ antiporter NhaC; Region: antiport_nhaC; TIGR00931 983545006634 Sodium:neurotransmitter symporter family; Region: SNF; cl11976 983545006635 carboxy-terminal protease; Provisional; Region: PRK11186 983545006636 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 983545006637 protein binding site [polypeptide binding]; other site 983545006638 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 983545006639 Catalytic dyad [active] 983545006640 ProP expression regulator; Provisional; Region: PRK04950 983545006641 FinO bacterial conjugation repressor domain; the basic protein FinO is part of the the two component FinOP system which is responsible for repressing bacterial conjugation; the FinOP system represses the transfer (tra) operon of the F-plasmid which...; Region: FinO_conjug_rep; cl15270 983545006642 GAF domain; Region: GAF; cl15785 983545006643 Cytochrome C'; Region: Cytochrom_C_2; cl01610 983545006644 chaperone protein DnaJ; Provisional; Region: PRK10767 983545006645 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 983545006646 HSP70 interaction site [polypeptide binding]; other site 983545006647 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262 983545006648 substrate binding site [polypeptide binding]; other site 983545006649 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 983545006650 Zn binding sites [ion binding]; other site 983545006651 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 983545006652 dimer interface [polypeptide binding]; other site 983545006653 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 983545006654 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 983545006655 dimer interface [polypeptide binding]; other site 983545006656 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 983545006657 Sodium:solute symporter family; Region: SSF; cl00456 983545006658 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 983545006659 PAS domain S-box; Region: sensory_box; TIGR00229 983545006660 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 983545006661 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080 983545006662 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 983545006663 ATP binding site [chemical binding]; other site 983545006664 Mg2+ binding site [ion binding]; other site 983545006665 G-X-G motif; other site 983545006666 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 983545006667 active site 983545006668 phosphorylation site [posttranslational modification] 983545006669 intermolecular recognition site; other site 983545006670 Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; cl09153 983545006671 Plasmid stabilisation system protein; Region: Plasmid_stabil; cl11422 983545006672 RDD family; Region: RDD; cl00746 983545006673 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 983545006674 active site 983545006675 phosphorylation site [posttranslational modification] 983545006676 intermolecular recognition site; other site 983545006677 Helix-turn-helix domains; Region: HTH; cl00088 983545006678 putative transposase OrfB; Reviewed; Region: PHA02517 983545006679 HTH-like domain; Region: HTH_21; pfam13276 983545006680 Integrase core domain; Region: rve; cl01316 983545006681 Integrase core domain; Region: rve_3; cl15866 983545006682 integron integrase; Region: integrase_gron; TIGR02249 983545006683 IntI (E2) integrases, site-specific tyrosine recombinases, DNA breaking-rejoining enzymes, N- and C-terminal domains. This CD includes integrases which are components of multiresistant integrons and mediate recombination between a proximal attI site and...; Region: INT_IntI; cd01193 983545006684 Int/Topo IB signature motif; other site 983545006685 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 983545006686 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 983545006687 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 983545006688 active site 983545006689 phosphorylation site [posttranslational modification] 983545006690 intermolecular recognition site; other site 983545006691 dimerization interface [polypeptide binding]; other site 983545006692 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 983545006693 DNA binding residues [nucleotide binding] 983545006694 dimerization interface [polypeptide binding]; other site 983545006695 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 983545006696 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 983545006697 N-terminal plug; other site 983545006698 ligand-binding site [chemical binding]; other site 983545006699 H+/gluconate symporter and related permeases [Carbohydrate transport and metabolism / Amino acid transport and metabolism]; Region: GntT; COG2610 983545006700 Na+-H+ antiporter family; Region: Na_H_antiport_2; cl15264 983545006701 homoserine O-acetyltransferase; Provisional; Region: PRK06765 983545006702 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 983545006703 Poly(3-hydroxybutyrate) depolymerase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: LpqC; COG3509 983545006704 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 983545006705 3-hydroxybutyrate dehydrogenase; Region: PHB_DH; TIGR01963 983545006706 NAD(P) binding site [chemical binding]; other site 983545006707 active site 983545006708 Microcystin-dependent protein [Function unknown]; Region: MdpB; COG4675 983545006709 Microcystin-dependent protein [Function unknown]; Region: MdpB; COG4675 983545006710 Microcystin-dependent protein [Function unknown]; Region: MdpB; COG4675 983545006711 catalase/hydroperoxidase HPI(I); Provisional; Region: PRK15061 983545006712 N-terminal catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_1; cd00649 983545006713 dimer interface [polypeptide binding]; other site 983545006714 active site 983545006715 heme binding site [chemical binding]; other site 983545006716 C-terminal non-catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_2; cd08200 983545006717 Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309 983545006718 Leucine-rich repeats; other site 983545006719 Substrate binding site [chemical binding]; other site 983545006720 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 983545006721 active site 983545006722 ATP binding site [chemical binding]; other site 983545006723 substrate binding site [chemical binding]; other site 983545006724 activation loop (A-loop); other site 983545006725 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 983545006726 Monoamine oxidase [Amino acid transport and metabolism]; Region: COG1231 983545006727 Protein with unknown function (DUF469); Region: DUF469; cl01237 983545006728 Family 41 Carbohydrate-Binding Module from pullulanase-like enzymes; Region: CBM41_pullulanase; cd10315 983545006729 carbohydrate binding site [chemical binding]; other site 983545006730 alpha-1,6-glucosidases, pullulanase-type; Region: pullul_strch; TIGR02103 983545006731 Early set domain associated with the catalytic domain of pullulanase (also called dextrinase and alpha-dextrin endo-1,6-alpha glucosidase); Region: E_set_Pullulanase; cd02860 983545006732 Alpha amylase catalytic domain found in Pullulanase (also called dextrinase; alpha-dextrin endo-1,6-alpha glucosidase), limit dextrinase, and related proteins; Region: AmyAc_Pullulanase_LD-like; cd11341 983545006733 Ca binding site [ion binding]; other site 983545006734 active site 983545006735 catalytic site [active] 983545006736 Early set domain associated with the catalytic domain of pullulanase-like proteins; Region: E_set_pullulanase_like; cd02861 983545006737 Early set domain associated with the catalytic domain of pullulanase-like proteins; Region: E_set_pullulanase_like; cd02861 983545006738 Early set domain associated with the catalytic domain of pullulanase-like proteins; Region: E_set_pullulanase_like; cd02861 983545006739 TonB-dependent receptor; Region: TonB-Xanth-Caul; TIGR01782 983545006740 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl00284 983545006741 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl00284 983545006742 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 983545006743 Dehydrogenases (flavoproteins) [Energy production and conversion]; Region: FixC; COG0644 983545006744 TonB-dependent receptor; Region: TonB-Xanth-Caul; TIGR01782 983545006745 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl00284 983545006746 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl00284 983545006747 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 983545006748 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 983545006749 thiazole biosynthesis adenylyltransferase ThiF, E. coli subfamily; Region: adenyl_thiF; TIGR02356 983545006750 ATP binding site [chemical binding]; other site 983545006751 substrate interface [chemical binding]; other site 983545006752 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 983545006753 active site residue [active] 983545006754 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 983545006755 dimer interface [polypeptide binding]; other site 983545006756 substrate binding site [chemical binding]; other site 983545006757 ATP binding site [chemical binding]; other site 983545006758 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 983545006759 thiamine phosphate binding site [chemical binding]; other site 983545006760 active site 983545006761 pyrophosphate binding site [ion binding]; other site 983545006762 Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728 983545006763 ThiS interaction site; other site 983545006764 putative active site [active] 983545006765 tetramer interface [polypeptide binding]; other site 983545006766 ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565 983545006767 thiS-thiF/thiG interaction site; other site 983545006768 Protoporphyrinogen oxidase [Coenzyme metabolism]; Region: HemY; COG1232 983545006769 glycine oxidase ThiO; Region: thiamin_ThiO; TIGR02352 983545006770 thiamine biosynthesis protein ThiC; Provisional; Region: PRK09284 983545006771 ThiC family; Region: ThiC; cl08031 983545006772 RRM (RNA recognition motif), also known as RBD (RNA binding domain) or RNP (ribonucleoprotein domain), is a highly abundant domain in eukaryotes found in proteins involved in post-transcriptional gene expression processes including mRNA and rRNA...; Region: RRM; cd00590 983545006773 RNA/DNA binding site [nucleotide binding]; other site 983545006774 RRM dimerization site [polypeptide binding]; other site 983545006775 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 983545006776 Old yellow enzyme (OYE)-related FMN binding domain, group 5. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a reducing agent with oxygens, quinones, and alpha,beta-unsaturated aldehydes and ketones, and can act as...; Region: OYE_like_5_FMN; cd04747 983545006777 putative active site [active] 983545006778 putative FMN binding site [chemical binding]; other site 983545006779 putative substrate binding site [chemical binding]; other site 983545006780 putative catalytic residue [active] 983545006781 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 983545006782 putative substrate translocation pore; other site 983545006783 outer membrane protein A; Reviewed; Region: PRK10808 983545006784 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 983545006785 carboxyltransferase (CT) interaction site; other site 983545006786 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 983545006787 biotinylation site [posttranslational modification]; other site 983545006788 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 983545006789 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 983545006790 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 983545006791 Predicted oxidoreductases (related to aryl-alcohol dehydrogenases) [Energy production and conversion]; Region: Tas; COG0667 983545006792 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 983545006793 active site 983545006794 catalytic tetrad [active] 983545006795 SpoU rRNA Methylase family; Region: SpoU_methylase; cl00362 983545006796 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 983545006797 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 983545006798 Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243 983545006799 The MopB_1 CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative N-terminal iron-sulfur [4Fe-4S] cluster binding site and molybdopterin cofactor binding site. These members belong to...; Region: MopB_1; cd02762 983545006800 putative [Fe4-S4] binding site [ion binding]; other site 983545006801 putative molybdopterin cofactor binding site [chemical binding]; other site 983545006802 The MopB_CT_1 CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative N-terminal iron-sulfur [4Fe-4S] cluster binding site and molybdopterin cofactor binding site. This CD is of the...; Region: MopB_CT_1; cd02782 983545006803 putative molybdopterin cofactor binding site; other site 983545006804 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3813 983545006805 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 983545006806 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 983545006807 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 983545006808 Walker A/P-loop; other site 983545006809 ATP binding site [chemical binding]; other site 983545006810 Q-loop/lid; other site 983545006811 ABC transporter signature motif; other site 983545006812 Walker B; other site 983545006813 D-loop; other site 983545006814 H-loop/switch region; other site 983545006815 Acidobacterial duplicated orphan permease; Region: ADOP; TIGR03434 983545006816 Acidobacterial duplicated orphan permease; Region: ADOP; TIGR03434 983545006817 MFS transporter, sugar porter (SP) family; Region: SP; TIGR00879 983545006818 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 983545006819 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 983545006820 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 983545006821 substrate binding site [chemical binding]; other site 983545006822 ATP binding site [chemical binding]; other site 983545006823 Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647 983545006824 active site 983545006825 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 983545006826 non-specific DNA binding site [nucleotide binding]; other site 983545006827 salt bridge; other site 983545006828 sequence-specific DNA binding site [nucleotide binding]; other site 983545006829 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 983545006830 Signal transduction histidine kinase, nitrate/nitrite-specific [Signal transduction mechanisms]; Region: NarQ; COG3850 983545006831 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 983545006832 dimerization interface [polypeptide binding]; other site 983545006833 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 983545006834 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl00284 983545006835 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 983545006836 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl00284 983545006837 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy; cl15773 983545006838 Transcriptional regulator [Transcription]; Region: IclR; COG1414 983545006839 Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615 983545006840 Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196 983545006841 Protein of unknown function (DUF465); Region: DUF465; cl01070 983545006842 Class III nucleotidyl cyclases; Region: Nucleotidyl_cyc_III; cl11967 983545006843 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 983545006844 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 983545006845 PAS domain; Region: PAS_9; pfam13426 983545006846 putative active site [active] 983545006847 heme pocket [chemical binding]; other site 983545006848 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 983545006849 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 983545006850 dimer interface [polypeptide binding]; other site 983545006851 putative CheW interface [polypeptide binding]; other site 983545006852 Response regulator containing a CheY-like receiver domain and an HD-GYP domain [Transcription / Signal transduction mechanisms]; Region: COG3437 983545006853 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 983545006854 active site 983545006855 phosphorylation site [posttranslational modification] 983545006856 intermolecular recognition site; other site 983545006857 dimerization interface [polypeptide binding]; other site 983545006858 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 983545006859 Zn2+ binding site [ion binding]; other site 983545006860 Mg2+ binding site [ion binding]; other site 983545006861 MHYT domain (predicted integral membrane sensor domain) [Signal transduction mechanisms]; Region: COG3300 983545006862 Bacterial signalling protein N terminal repeat; Region: MHYT; pfam03707 983545006863 Bacterial signalling protein N terminal repeat; Region: MHYT; pfam03707 983545006864 Bacterial signalling protein N terminal repeat; Region: MHYT; pfam03707 983545006865 PAS domain S-box; Region: sensory_box; TIGR00229 983545006866 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 983545006867 putative active site [active] 983545006868 heme pocket [chemical binding]; other site 983545006869 PAS domain S-box; Region: sensory_box; TIGR00229 983545006870 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 983545006871 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 983545006872 dimer interface [polypeptide binding]; other site 983545006873 phosphorylation site [posttranslational modification] 983545006874 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 983545006875 ATP binding site [chemical binding]; other site 983545006876 Mg2+ binding site [ion binding]; other site 983545006877 G-X-G motif; other site 983545006878 Response regulator receiver domain; Region: Response_reg; pfam00072 983545006879 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 983545006880 active site 983545006881 phosphorylation site [posttranslational modification] 983545006882 intermolecular recognition site; other site 983545006883 dimerization interface [polypeptide binding]; other site 983545006884 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cl00086 983545006885 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 983545006886 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 983545006887 active site 983545006888 phosphorylation site [posttranslational modification] 983545006889 intermolecular recognition site; other site 983545006890 dimerization interface [polypeptide binding]; other site 983545006891 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 983545006892 DNA binding site [nucleotide binding] 983545006893 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 983545006894 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 983545006895 dimer interface [polypeptide binding]; other site 983545006896 phosphorylation site [posttranslational modification] 983545006897 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 983545006898 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 983545006899 GAF domain; Region: GAF; cl15785 983545006900 GAF domain; Region: GAF_2; pfam13185 983545006901 GAF domain; Region: GAF; cl15785 983545006902 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 983545006903 metal binding site [ion binding]; metal-binding site 983545006904 active site 983545006905 I-site; other site 983545006906 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 983545006907 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 983545006908 Helix-turn-helix domains; Region: HTH; cl00088 983545006909 Predicted oxidoreductases (related to aryl-alcohol dehydrogenases) [Energy production and conversion]; Region: Tas; COG0667 983545006910 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 983545006911 active site 983545006912 catalytic tetrad [active] 983545006913 AraC-type transcriptional regulator N-terminus; Region: AraC_N; pfam06719 983545006914 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 983545006915 hypothetical protein; Provisional; Region: PRK11281 983545006916 Mechanosensitive ion channel inner membrane domain 1; Region: MscS_TM; pfam12794 983545006917 Mechanosensitive ion channel; Region: MS_channel; pfam00924 983545006918 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 983545006919 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 983545006920 N-terminal plug; other site 983545006921 ligand-binding site [chemical binding]; other site 983545006922 Siderophore-interacting protein [Inorganic ion transport and metabolism]; Region: ViuB; COG2375 983545006923 Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193 983545006924 FAD binding pocket [chemical binding]; other site 983545006925 FAD binding motif [chemical binding]; other site 983545006926 phosphate binding motif [ion binding]; other site 983545006927 NAD binding pocket [chemical binding]; other site 983545006928 AIDA autotransporter-like protein ShdA; Provisional; Region: PRK15319 983545006929 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 983545006930 non-specific DNA binding site [nucleotide binding]; other site 983545006931 salt bridge; other site 983545006932 sequence-specific DNA binding site [nucleotide binding]; other site 983545006933 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 983545006934 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 983545006935 Protein of unknown function (DUF2750); Region: DUF2750; pfam11042 983545006936 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 983545006937 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 983545006938 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383 983545006939 chlorocatechol 1,2-dioxygenase; Region: chlorocat_1_2; TIGR02465 983545006940 active site 983545006941 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 983545006942 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 983545006943 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776 983545006944 N-terminal domain interface [polypeptide binding]; other site 983545006945 GntP family permease; Region: GntP_permease; pfam02447 983545006946 Na+-H+ antiporter family; Region: Na_H_antiport_2; cl15264 983545006947 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_2; cd06150 983545006948 homotrimer interaction site [polypeptide binding]; other site 983545006949 putative active site [active] 983545006950 DNA helicase IV; Provisional; Region: helD; PRK11054 983545006951 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 983545006952 DNA helicase IV; Provisional; Region: helD; PRK11054 983545006953 Family description; Region: UvrD_C_2; cl15862 983545006954 Protein of unknown function (DUF421); Region: DUF421; cl00990 983545006955 UPF0126 domain; Region: UPF0126; pfam03458 983545006956 Predicted membrane protein [Function unknown]; Region: COG2860 983545006957 UPF0126 domain; Region: UPF0126; pfam03458 983545006958 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 983545006959 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 983545006960 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 983545006961 PAS domain; Region: PAS_9; pfam13426 983545006962 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 983545006963 PAS fold; Region: PAS_3; pfam08447 983545006964 putative active site [active] 983545006965 heme pocket [chemical binding]; other site 983545006966 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 983545006967 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 983545006968 dimer interface [polypeptide binding]; other site 983545006969 phosphorylation site [posttranslational modification] 983545006970 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 983545006971 ATP binding site [chemical binding]; other site 983545006972 Mg2+ binding site [ion binding]; other site 983545006973 G-X-G motif; other site 983545006974 Response regulator receiver domain; Region: Response_reg; pfam00072 983545006975 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 983545006976 active site 983545006977 phosphorylation site [posttranslational modification] 983545006978 intermolecular recognition site; other site 983545006979 dimerization interface [polypeptide binding]; other site 983545006980 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy; cl15773 983545006981 Family of homologous FMN-dependent alpha-hydroxyacid oxidizing enzymes. This family occurs in both prokaryotes and eukaryotes. Members of this family include flavocytochrome b2 (FCB2), glycolate oxidase (GOX), lactate monooxygenase (LMO), mandelate...; Region: alpha_hydroxyacid_oxid_FMN; cd02809 983545006982 FMN-dependent dehydrogenase; Region: FMN_dh; pfam01070 983545006983 active site 983545006984 substrate binding site [chemical binding]; other site 983545006985 FMN binding site [chemical binding]; other site 983545006986 putative catalytic residues [active] 983545006987 Outer membrane receptor for monomeric catechols [Inorganic ion transport and metabolism]; Region: Fiu; COG4774 983545006988 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 983545006989 N-terminal plug; other site 983545006990 ligand-binding site [chemical binding]; other site 983545006991 Gram-negative bacterial tonB protein; Region: TonB; cl10048 983545006992 Biopolymer transport protein ExbD/TolR; Region: ExbD; cl00537 983545006993 Biopolymer transport protein ExbD/TolR; Region: ExbD; cl00537 983545006994 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 983545006995 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 983545006996 FAD binding domain; Region: FAD_binding_4; pfam01565 983545006997 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 983545006998 Cysteine-rich domain; Region: CCG; pfam02754 983545006999 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_ATP; cd00484 983545007000 active site 983545007001 substrate-binding site [chemical binding]; other site 983545007002 metal-binding site [ion binding] 983545007003 ATP binding site [chemical binding]; other site 983545007004 Protein of unknown function (DUF1428); Region: DUF1428; cl02319 983545007005 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 983545007006 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 983545007007 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 983545007008 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 983545007009 Cupin domain; Region: Cupin_2; cl09118 983545007010 Cupin domain; Region: Cupin_2; cl09118 983545007011 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 983545007012 classical (c) SDRs; Region: SDR_c; cd05233 983545007013 NAD(P) binding site [chemical binding]; other site 983545007014 active site 983545007015 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 983545007016 histidinol dehydrogenase; Region: hisD; TIGR00069 983545007017 NAD binding site [chemical binding]; other site 983545007018 dimerization interface [polypeptide binding]; other site 983545007019 product binding site; other site 983545007020 substrate binding site [chemical binding]; other site 983545007021 zinc binding site [ion binding]; other site 983545007022 catalytic residues [active] 983545007023 Transcriptional regulators [Transcription]; Region: PurR; COG1609 983545007024 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 983545007025 DNA binding site [nucleotide binding] 983545007026 domain linker motif; other site 983545007027 Ligand-binding domain of uncharacterized DNA-binding regulatory proteins that are members of the LacI-GalR family of bacterial transcription repressors; Region: PBP1_LacI_like_2; cd06278 983545007028 putative dimerization interface [polypeptide binding]; other site 983545007029 putative ligand binding site [chemical binding]; other site 983545007030 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 983545007031 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 983545007032 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase [Carbohydrate transport and metabolism]; Region: HpcH; COG3836 983545007033 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl09155 983545007034 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 983545007035 Ligand Binding Site [chemical binding]; other site 983545007036 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 983545007037 Walker A motif; other site 983545007038 ATP binding site [chemical binding]; other site 983545007039 Walker B motif; other site 983545007040 AAA domain; Region: AAA_33; pfam13671 983545007041 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 983545007042 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 983545007043 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 983545007044 Sodium:solute symporter family; Region: SSF; cl00456 983545007045 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 983545007046 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 983545007047 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 983545007048 N-terminal plug; other site 983545007049 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 983545007050 ligand-binding site [chemical binding]; other site 983545007051 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 983545007052 Domain of unknown function (DUF4386); Region: DUF4386; pfam14329 983545007053 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 983545007054 Coenzyme A binding pocket [chemical binding]; other site 983545007055 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 983545007056 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_19; cd07262 983545007057 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 983545007058 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 983545007059 Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron transfer between NADP(H) and electron carrier proteins such as ferredoxin and flavodoxin. Isoforms of these flavoproteins (i.e. having a non-covalently...; Region: FNR1; cd06195 983545007060 FAD binding pocket [chemical binding]; other site 983545007061 FAD binding motif [chemical binding]; other site 983545007062 phosphate binding motif [ion binding]; other site 983545007063 beta-alpha-beta structure motif; other site 983545007064 NAD binding pocket [chemical binding]; other site 983545007065 Glycosyl hydrolases family 15; Region: Glyco_hydro_15; pfam00723 983545007066 Glycosyl hydrolases family 15; Region: Glyco_hydro_15; pfam00723 983545007067 LysE type translocator; Region: LysE; cl00565 983545007068 C-5 cytosine-specific DNA methylase; Region: DNA_methylase; pfam00145 983545007069 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl15754 983545007070 cofactor binding site; other site 983545007071 DNA binding site [nucleotide binding] 983545007072 substrate interaction site [chemical binding]; other site 983545007073 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl15754 983545007074 Protein of unknown function DUF262; Region: DUF262; cl14890 983545007075 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 983545007076 AAA domain; Region: AAA_21; pfam13304 983545007077 Walker A/P-loop; other site 983545007078 ATP binding site [chemical binding]; other site 983545007079 Uncharacterized conserved protein [Function unknown]; Region: COG4938 983545007080 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 983545007081 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 983545007082 active site 983545007083 phosphorylation site [posttranslational modification] 983545007084 intermolecular recognition site; other site 983545007085 dimerization interface [polypeptide binding]; other site 983545007086 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 983545007087 DNA binding residues [nucleotide binding] 983545007088 dimerization interface [polypeptide binding]; other site 983545007089 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4564 983545007090 Cache domain; Region: Cache_2; cl07034 983545007091 Histidine kinase; Region: HisKA_3; pfam07730 983545007092 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 983545007093 ATP binding site [chemical binding]; other site 983545007094 Mg2+ binding site [ion binding]; other site 983545007095 G-X-G motif; other site 983545007096 TRAP-type mannitol/chloroaromatic compound transport system, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FcbT1; COG4663 983545007097 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441 983545007098 Tripartite ATP-independent periplasmic transporters, DctQ component; Region: DctQ; cl01181 983545007099 C4-dicarboxylate anaerobic carrier; Region: DcuC; cl15356 983545007100 DctM-like transporters; Region: DctM; pfam06808 983545007101 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl00284 983545007102 Cu/Zn superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodC; COG2032 983545007103 Cytochrome b562; Region: Cytochrom_B562; cl01546 983545007104 Copper/zinc superoxide dismutase (SOD). superoxide dismutases catalyse the conversion of superoxide radicals to molecular oxygen. Three evolutionarily distinct families of SODs are known, of which the copper/zinc-binding family is one. Defects in the...; Region: Cu-Zn_Superoxide_Dismutase; cd00305 983545007105 E-class dimer interface [polypeptide binding]; other site 983545007106 P-class dimer interface [polypeptide binding]; other site 983545007107 active site 983545007108 Cu2+ binding site [ion binding]; other site 983545007109 Zn2+ binding site [ion binding]; other site 983545007110 Protein of unknown function (DUF2185); Region: DUF2185; cl02019 983545007111 CpxP component of the bacterial Cpx-two-component system and related proteins; Region: CpxP_like; cd09916 983545007112 dimer interface [polypeptide binding]; other site 983545007113 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 983545007114 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 983545007115 active site 983545007116 phosphorylation site [posttranslational modification] 983545007117 intermolecular recognition site; other site 983545007118 dimerization interface [polypeptide binding]; other site 983545007119 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 983545007120 DNA binding site [nucleotide binding] 983545007121 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 983545007122 dimer interface [polypeptide binding]; other site 983545007123 phosphorylation site [posttranslational modification] 983545007124 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 983545007125 ATP binding site [chemical binding]; other site 983545007126 Mg2+ binding site [ion binding]; other site 983545007127 G-X-G motif; other site 983545007128 phenylpropionate dioxygenase ferredoxin reductase subunit; Provisional; Region: PRK09754 983545007129 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 983545007130 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cl00159 983545007131 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; cl12078 983545007132 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 983545007133 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 983545007134 Zn-dependent alcohol dehydrogenases, class III [Energy production and conversion]; Region: AdhC; COG1062 983545007135 Class III alcohol dehydrogenase; Region: Zn_ADH_class_III; cd08279 983545007136 NAD binding site [chemical binding]; other site 983545007137 catalytic Zn binding site [ion binding]; other site 983545007138 substrate binding site [chemical binding]; other site 983545007139 structural Zn binding site [ion binding]; other site 983545007140 Putative esterase; Region: Esterase; pfam00756 983545007141 accessory Sec system protein Asp2; Region: acc_sec_asp2; TIGR03712 983545007142 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 983545007143 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 983545007144 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 983545007145 Catalytic site [active] 983545007146 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 983545007147 Tetratricopeptide repeat; Region: TPR_12; pfam13424 983545007148 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 983545007149 binding surface 983545007150 TPR motif; other site 983545007151 Tetratricopeptide repeat; Region: TPR_12; pfam13424 983545007152 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 983545007153 Tetratricopeptide repeat; Region: TPR_12; pfam13424 983545007154 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 983545007155 metal binding site [ion binding]; metal-binding site 983545007156 active site 983545007157 I-site; other site 983545007158 2-enoyl thioester reductase (ETR) like proteins, child 1; Region: ETR_like_1; cd08291 983545007159 NADP binding site [chemical binding]; other site 983545007160 dimer interface [polypeptide binding]; other site 983545007161 Transcriptional regulator [Transcription]; Region: LysR; COG0583 983545007162 Helix-turn-helix domains; Region: HTH; cl00088 983545007163 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 983545007164 putative effector binding pocket; other site 983545007165 dimerization interface [polypeptide binding]; other site 983545007166 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 983545007167 DNA binding site [nucleotide binding] 983545007168 A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the 'double-glycine' leader peptides from the precursors of various bacteriocins; Region: Peptidase_C39G; cd02423 983545007169 putative active site [active] 983545007170 Putative MetA-pathway of phenol degradation; Region: Phenol_MetA_deg; cl01768 983545007171 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 983545007172 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 983545007173 N-terminal plug; other site 983545007174 ligand-binding site [chemical binding]; other site 983545007175 Putative cyclase; Region: Cyclase; cl00814 983545007176 3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK06130 983545007177 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 983545007178 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 983545007179 Prokaryotic protein of unknown function (DUF849); Region: DUF849; cl15827 983545007180 Cupin domain; Region: Cupin_2; cl09118 983545007181 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 983545007182 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 983545007183 NAD(P) binding site [chemical binding]; other site 983545007184 active site 983545007185 Sodium:solute symporter family; Region: SSF; cl00456 983545007186 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 983545007187 Transcriptional regulator [Transcription]; Region: IclR; COG1414 983545007188 Helix-turn-helix domains; Region: HTH; cl00088 983545007189 Bacterial transcriptional regulator; Region: IclR; pfam01614 983545007190 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 983545007191 PseudoU_synth_RsuA/RluD: Pseudouridine synthase, RsuA/RluD family. This group is comprised of eukaryotic, bacterial and archeal proteins similar to eight site specific Escherichia coli pseudouridine synthases: RsuA, RluA, RluB, RluC, RluD, RluE, RluF and...; Region: PseudoU_synth_RluCD_like; cd02869 983545007192 active site 983545007193 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 983545007194 Major Facilitator Superfamily; Region: MFS_1; pfam07690 983545007195 putative substrate translocation pore; other site 983545007196 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 983545007197 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 983545007198 DEAD-like helicases superfamily; Region: DEXDc; smart00487 983545007199 ATP binding site [chemical binding]; other site 983545007200 Mg++ binding site [ion binding]; other site 983545007201 motif III; other site 983545007202 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 983545007203 nucleotide binding region [chemical binding]; other site 983545007204 ATP-binding site [chemical binding]; other site 983545007205 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 983545007206 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 983545007207 N-terminal plug; other site 983545007208 ligand-binding site [chemical binding]; other site 983545007209 Transcriptional regulator [Transcription]; Region: LysR; COG0583 983545007210 Helix-turn-helix domains; Region: HTH; cl00088 983545007211 The C-terminal substrate binding domain of LysR-type transcriptional regulators that involved in the catabolism of nitroaromatic/naphthalene compounds and that of related regulators; contains the type 2 periplasmic binding fold; Region: PBP2_Nitroaromatics_like; cd08417 983545007212 dimerization interface [polypeptide binding]; other site 983545007213 substrate binding pocket [chemical binding]; other site 983545007214 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cl00214 983545007215 intersubunit interface [polypeptide binding]; other site 983545007216 active site 983545007217 Zn2+ binding site [ion binding]; other site 983545007218 Peptidase M14-like domain; uncharacterized subfamily; Region: M14-like_4; cd06231 983545007219 putative active site [active] 983545007220 Zn binding site [ion binding]; other site 983545007221 Ribbon-helix-helix domain; Region: RHH_4; cl01775 983545007222 Predicted HD superfamily hydrolase [General function prediction only]; Region: COG1418 983545007223 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 983545007224 Excalibur calcium-binding domain; Region: Excalibur; cl05460 983545007225 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 983545007226 conserved hypothetical protein; Region: TIGR02285 983545007227 Galactose mutarotase-like; Region: Gal_mutarotas_2; pfam13802 983545007228 CtsZ (cyclic tetrasaccharide-synthesizing enzyme Z) is a bacterial 6-alpha-glucosyltransferase, first identified in Arthrobacter globiformis, that produces cyclic tetrasaccharides together with a closely related enzyme CtsY. CtsZ and CtsY both have a...; Region: GH31_transferase_CtsZ; cd06598 983545007229 putative active site [active] 983545007230 putative catalytic site [active] 983545007231 Putative esterase; Region: Esterase; pfam00756 983545007232 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 983545007233 Alpha amylase catalytic domain found in an uncharacterized protein family; Region: AmyAc_3; cd11349 983545007234 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 983545007235 active site 983545007236 catalytic site [active] 983545007237 Uncharacterized ACR, COG2135; Region: DUF159; cl03646 983545007238 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4337 983545007239 Helix-Turn-Helix DNA binding domain of putative transcription regulators from the MerR superfamily; Region: HTH_MerR-like_sg6; cd04781 983545007240 Cu(I)-responsive transcriptional regulator; Region: CueR; TIGR02044 983545007241 DNA binding residues [nucleotide binding] 983545007242 putative dimer interface [polypeptide binding]; other site 983545007243 putative metal binding residues [ion binding]; other site 983545007244 Protein of unknown function (DUF2938); Region: DUF2938; pfam11158 983545007245 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 983545007246 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 983545007247 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 983545007248 GIY-YIG motif/motif A; other site 983545007249 active site 983545007250 catalytic site [active] 983545007251 putative DNA binding site [nucleotide binding]; other site 983545007252 metal binding site [ion binding]; metal-binding site 983545007253 UvrB/uvrC motif; Region: UVR; pfam02151 983545007254 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 983545007255 response regulator; Provisional; Region: PRK09483 983545007256 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 983545007257 active site 983545007258 phosphorylation site [posttranslational modification] 983545007259 intermolecular recognition site; other site 983545007260 dimerization interface [polypeptide binding]; other site 983545007261 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 983545007262 DNA binding residues [nucleotide binding] 983545007263 dimerization interface [polypeptide binding]; other site 983545007264 YccA-like proteins; Region: YccA_like; cd10433 983545007265 DsrE/DsrF-like family; Region: DrsE; cl00672 983545007266 DsrE/DsrF-like family; Region: DrsE; cl00672 983545007267 DsrE/DsrF-like family; Region: DrsE; cl00672 983545007268 DsrC like protein; Region: DsrC; cl01101 983545007269 seryl-tRNA synthetase; Provisional; Region: PRK05431 983545007270 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 983545007271 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme bound...; Region: SerRS_core; cd00770 983545007272 dimer interface [polypeptide binding]; other site 983545007273 active site 983545007274 motif 1; other site 983545007275 motif 2; other site 983545007276 motif 3; other site 983545007277 CrcB-like protein; Region: CRCB; cl09114 983545007278 recombination factor protein RarA; Reviewed; Region: PRK13342 983545007279 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 983545007280 Walker A motif; other site 983545007281 ATP binding site [chemical binding]; other site 983545007282 Walker B motif; other site 983545007283 arginine finger; other site 983545007284 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 983545007285 Outer membrane lipoprotein carrier protein LolA; Region: LolA; cl01065 983545007286 lipoprotein chaperone; Reviewed; Region: lolA; PRK00031 983545007287 Domain of unknown function (DUF4117); Region: DUF4117; pfam13491 983545007288 DNA translocase FtsK; Provisional; Region: PRK10263 983545007289 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 983545007290 Ftsk gamma domain; Region: Ftsk_gamma; cl09645 983545007291 leucine-responsive transcriptional regulator; Provisional; Region: PRK11169 983545007292 Helix-turn-helix domains; Region: HTH; cl00088 983545007293 Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686 983545007294 Alanine dehydrogenase/PNT, N-terminal domain; Region: AlaDh_PNT_N; cl15379 983545007295 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 983545007296 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase contains two...; Region: OMP_decarboxylase_like; cd04725 983545007297 active site 983545007298 dimer interface [polypeptide binding]; other site 983545007299 tetratricopeptide repeat protein; Provisional; Region: PRK11788 983545007300 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 983545007301 binding surface 983545007302 TPR motif; other site 983545007303 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 983545007304 binding surface 983545007305 TPR motif; other site 983545007306 Protein of unknown function (DUF1049); Region: DUF1049; cl01539 983545007307 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 983545007308 IHF dimer interface [polypeptide binding]; other site 983545007309 IHF - DNA interface [nucleotide binding]; other site 983545007310 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06299 983545007311 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 983545007312 RNA binding site [nucleotide binding]; other site 983545007313 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 983545007314 RNA binding site [nucleotide binding]; other site 983545007315 S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists of...; Region: S1_RPS1_repeat_ec3; cd05688 983545007316 RNA binding site [nucleotide binding]; other site 983545007317 S1_RPS1_repeat_ec4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists of...; Region: S1_RPS1_repeat_ec4; cd05689 983545007318 RNA binding site [nucleotide binding]; other site 983545007319 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 983545007320 RNA binding site [nucleotide binding]; other site 983545007321 S1_RPS1_repeat_ec6: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists of...; Region: S1_RPS1_repeat_ec6; cd05691 983545007322 RNA binding site [nucleotide binding]; other site 983545007323 cytidylate kinase; Provisional; Region: cmk; PRK00023 983545007324 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 983545007325 CMP-binding site; other site 983545007326 The sites determining sugar specificity; other site 983545007327 3-phosphoshikimate 1-carboxyvinyltransferase; Region: PLN02338 983545007328 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 983545007329 hinge; other site 983545007330 active site 983545007331 Phosphoserine aminotransferase (PSAT) family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major group in this CD corresponds to phosphoserine aminotransferase (PSAT). PSAT is active as...; Region: PSAT_like; cd00611 983545007332 homodimer interface [polypeptide binding]; other site 983545007333 substrate-cofactor binding pocket; other site 983545007334 pyridoxal 5'-phosphate binding site [chemical binding]; other site 983545007335 catalytic residue [active] 983545007336 DNA gyrase subunit A; Validated; Region: PRK05560 983545007337 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes in DNA...; Region: TOP4c; cd00187 983545007338 CAP-like domain; other site 983545007339 active site 983545007340 primary dimer interface [polypeptide binding]; other site 983545007341 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 983545007342 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 983545007343 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 983545007344 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 983545007345 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 983545007346 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 983545007347 bifunctional 3-demethylubiquinone-9 3-methyltransferase/ 2-octaprenyl-6-hydroxy phenol methylase; Provisional; Region: PRK05134 983545007348 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 983545007349 S-adenosylmethionine binding site [chemical binding]; other site 983545007350 phosphoglycolate phosphatase; Provisional; Region: PRK13226 983545007351 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 983545007352 motif II; other site 983545007353 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK09103 983545007354 ATP cone domain; Region: ATP-cone; pfam03477 983545007355 Class I ribonucleotide reductase; Region: RNR_I; cd01679 983545007356 active site 983545007357 dimer interface [polypeptide binding]; other site 983545007358 catalytic residues [active] 983545007359 effector binding site; other site 983545007360 R2 peptide binding site; other site 983545007361 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 983545007362 dimer interface [polypeptide binding]; other site 983545007363 putative radical transfer pathway; other site 983545007364 diiron center [ion binding]; other site 983545007365 tyrosyl radical; other site 983545007366 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 983545007367 catalytic loop [active] 983545007368 iron binding site [ion binding]; other site 983545007369 exosortase A system-associated amidotransferase 1; Region: eps_aminotran_1; TIGR03108 983545007370 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 983545007371 active site 983545007372 dimer interface [polypeptide binding]; other site 983545007373 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 983545007374 Ligand Binding Site [chemical binding]; other site 983545007375 Molecular Tunnel; other site 983545007376 non-metazoan 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_Sc; cd01414 983545007377 ATP binding site [chemical binding]; other site 983545007378 active site 983545007379 substrate binding site [chemical binding]; other site 983545007380 Uncharacterized lipoprotein [Cell envelope biogenesis, outer membrane]; Region: NlpB; COG3317 983545007381 NlpB/DapX lipoprotein; Region: Lipoprotein_18; pfam06804 983545007382 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 983545007383 dihydrodipicolinate synthase; Region: dapA; TIGR00674 983545007384 dimer interface [polypeptide binding]; other site 983545007385 active site 983545007386 catalytic residue [active] 983545007387 Glycine cleavage system regulatory protein [Amino acid transport and metabolism]; Region: GcvR; COG2716 983545007388 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 983545007389 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 983545007390 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 983545007391 catalytic triad [active] 983545007392 Domain of unknown function DUF20; Region: UPF0118; pfam01594 983545007393 pheromone autoinducer 2 transporter; Reviewed; Region: tqsA; cl00465 983545007394 Putative Zn-dependent protease, contains TPR repeats [General function prediction only]; Region: COG4783 983545007395 Peptidase family M48; Region: Peptidase_M48; cl12018 983545007396 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 983545007397 binding surface 983545007398 TPR motif; other site 983545007399 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 983545007400 catalytic residues [active] 983545007401 Arsenate Reductase (ArsC) family, ArsC subfamily; arsenic reductases similar to that encoded by arsC on the R733 plasmid of Escherichia coli. E. coli ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], the first step in the...; Region: ArsC_ArsC; cd03034 983545007402 ArsC family; Region: ArsC; pfam03960 983545007403 catalytic residues [active] 983545007404 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 983545007405 Predicted membrane protein (DUF2069); Region: DUF2069; cl01299 983545007406 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 983545007407 DnaA regulatory inactivator Hda; Region: DnaA_homol_Hda; TIGR03420 983545007408 Uncharacterized protein conserved in bacteria (DUF2066); Region: DUF2066; pfam09839 983545007409 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 983545007410 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 983545007411 dimerization interface [polypeptide binding]; other site 983545007412 putative ATP binding site [chemical binding]; other site 983545007413 phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647 983545007414 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 983545007415 active site 983545007416 substrate binding site [chemical binding]; other site 983545007417 cosubstrate binding site; other site 983545007418 catalytic site [active] 983545007419 Protein of unknown function (DUF3108); Region: DUF3108; pfam11306 983545007420 acyl-CoA dehydrogenase; Reviewed; Region: fadE; PRK09463 983545007421 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 983545007422 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 983545007423 active site 983545007424 Domain of unknown function (DUF1974); Region: DUF1974; pfam09317 983545007425 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 983545007426 IHF dimer interface [polypeptide binding]; other site 983545007427 IHF - DNA interface [nucleotide binding]; other site 983545007428 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 983545007429 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 983545007430 putative tRNA-binding site [nucleotide binding]; other site 983545007431 B3/4 domain; Region: B3_4; cl11458 983545007432 tRNA synthetase B5 domain; Region: B5; cl08394 983545007433 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 983545007434 dimer interface [polypeptide binding]; other site 983545007435 motif 1; other site 983545007436 motif 3; other site 983545007437 motif 2; other site 983545007438 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; cl08386 983545007439 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 983545007440 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 983545007441 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 983545007442 dimer interface [polypeptide binding]; other site 983545007443 motif 1; other site 983545007444 active site 983545007445 motif 2; other site 983545007446 motif 3; other site 983545007447 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 983545007448 23S rRNA binding site [nucleotide binding]; other site 983545007449 L21 binding site [polypeptide binding]; other site 983545007450 L13 binding site [polypeptide binding]; other site 983545007451 Ribosomal protein L35; Region: Ribosomal_L35p; cl00392 983545007452 translation initiation factor IF-3; Region: infC; TIGR00168 983545007453 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 983545007454 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 983545007455 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413 983545007456 TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667 983545007457 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; cl08469 983545007458 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 983545007459 active site 983545007460 dimer interface [polypeptide binding]; other site 983545007461 motif 1; other site 983545007462 motif 2; other site 983545007463 motif 3; other site 983545007464 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 983545007465 anticodon binding site; other site 983545007466 pteridine reductase; Provisional; Region: PRK09135 983545007467 pteridine reductase (PR), classical (c) SDRs; Region: PR_SDR_c; cd05357 983545007468 NADP binding site [chemical binding]; other site 983545007469 substrate binding pocket [chemical binding]; other site 983545007470 active site 983545007471 Protein of unknown function (DUF3080); Region: DUF3080; pfam11279 983545007472 DNA polymerase III subunit epsilon; Validated; Region: PRK09182 983545007473 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 983545007474 active site 983545007475 substrate binding site [chemical binding]; other site 983545007476 catalytic site [active] 983545007477 Predicted signal-transduction protein containing cAMP-binding and CBS domains [Signal transduction mechanisms]; Region: COG2905 983545007478 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 983545007479 ligand binding site [chemical binding]; other site 983545007480 flexible hinge region; other site 983545007481 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with either the CAP_ED (cAMP receptor protein effector domain) family of transcription factors and the DUF294 domain or the PB1 (Phox and Bem1p) domain; Region: CBS_pair_CAP-ED_DUF294_PBI_assoc2; cd04800 983545007482 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 983545007483 metal binding triad; other site 983545007484 BCCT family transporter; Region: BCCT; cl00569 983545007485 Phosphate-selective porin O and P; Region: Porin_O_P; cl01524 983545007486 Domain of unknown function (DUF4102); Region: DUF4102; pfam13356 983545007487 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 983545007488 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 983545007489 DNA binding site [nucleotide binding] 983545007490 Int/Topo IB signature motif; other site 983545007491 active site 983545007492 catalytic residues [active] 983545007493 potential frameshift: common BLAST hit: gi|209397642|ref|YP_002271427.1| phage portal protein, lambda family 983545007494 signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706 983545007495 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_1; cd07016 983545007496 oligomer interface [polypeptide binding]; other site 983545007497 active site residues [active] 983545007498 HIRAN domain; Region: HIRAN; cl07418 983545007499 chemotaxis-specific methylesterase; Provisional; Region: PRK00742 983545007500 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 983545007501 active site 983545007502 phosphorylation site [posttranslational modification] 983545007503 intermolecular recognition site; other site 983545007504 dimerization interface [polypeptide binding]; other site 983545007505 CheB methylesterase; Region: CheB_methylest; pfam01339 983545007506 CheD chemotactic sensory transduction; Region: CheD; cl00810 983545007507 chemotaxis methyltransferase CheR; Provisional; Region: PRK10611 983545007508 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 983545007509 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 983545007510 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 983545007511 PAS domain; Region: PAS_9; pfam13426 983545007512 putative active site [active] 983545007513 heme pocket [chemical binding]; other site 983545007514 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 983545007515 PAS domain; Region: PAS_9; pfam13426 983545007516 putative active site [active] 983545007517 heme pocket [chemical binding]; other site 983545007518 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 983545007519 PAS domain; Region: PAS_9; pfam13426 983545007520 putative active site [active] 983545007521 heme pocket [chemical binding]; other site 983545007522 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 983545007523 PAS domain; Region: PAS_9; pfam13426 983545007524 putative active site [active] 983545007525 heme pocket [chemical binding]; other site 983545007526 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 983545007527 dimer interface [polypeptide binding]; other site 983545007528 putative CheW interface [polypeptide binding]; other site 983545007529 CheW, a small regulator protein, unique to the chemotaxis signalling in prokaryotes and archea. CheW interacts with the histidine kinase CheA, most likely with the related regulatory domain of CheA. CheW is proposed to form signalling arrays together...; Region: CheW; cd00732 983545007530 putative CheA interaction surface; other site 983545007531 Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643 983545007532 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 983545007533 putative binding surface; other site 983545007534 active site 983545007535 Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895 983545007536 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 983545007537 CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731 983545007538 Response regulator receiver domain; Region: Response_reg; pfam00072 983545007539 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 983545007540 active site 983545007541 phosphorylation site [posttranslational modification] 983545007542 intermolecular recognition site; other site 983545007543 dimerization interface [polypeptide binding]; other site 983545007544 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 983545007545 Response regulator receiver domain; Region: Response_reg; pfam00072 983545007546 active site 983545007547 phosphorylation site [posttranslational modification] 983545007548 intermolecular recognition site; other site 983545007549 dimerization interface [polypeptide binding]; other site 983545007550 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cl00120 983545007551 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 983545007552 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 983545007553 anti sigma factor interaction site; other site 983545007554 regulatory phosphorylation site [posttranslational modification]; other site 983545007555 Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396 983545007556 Uncharacterized conserved protein [Function unknown]; Region: COG3603 983545007557 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 983545007558 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cl00162 983545007559 HPr interaction site; other site 983545007560 glycerol kinase (GK) interaction site [polypeptide binding]; other site 983545007561 active site 983545007562 phosphorylation site [posttranslational modification] 983545007563 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 983545007564 Tat (twin-arginine translocation) pathway signal sequence; Region: TAT_signal_seq; TIGR01409 983545007565 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 983545007566 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; cl03161 983545007567 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 983545007568 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 983545007569 4-hydroxybenzoyl-CoA reductase, gamma subunit; Region: 4hydroxCoAred; TIGR03193 983545007570 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cl00159 983545007571 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 983545007572 GT_2_like_f is a subfamily of the glycosyltransferase family 2 (GT-2) with unknown function; Region: GT_2_like_f; cd04182 983545007573 molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317 983545007574 Ligand binding site; other site 983545007575 metal-binding site 983545007576 xanthine dehydrogenase accessory protein XdhC; Region: xanthine_xdhC; TIGR02964 983545007577 XdhC and CoxI family; Region: XdhC_CoxI; pfam02625 983545007578 XdhC Rossmann domain; Region: XdhC_C; pfam13478 983545007579 RDD family; Region: RDD; cl00746 983545007580 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 983545007581 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 983545007582 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 983545007583 Walker A motif; other site 983545007584 ATP binding site [chemical binding]; other site 983545007585 Walker B motif; other site 983545007586 arginine finger; other site 983545007587 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 983545007588 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 983545007589 dimer interface [polypeptide binding]; other site 983545007590 pyridoxal 5'-phosphate binding site [chemical binding]; other site 983545007591 catalytic residue [active] 983545007592 Protein of unknown function (DUF1006); Region: DUF1006; cl15826 983545007593 Rhomboid family; Region: Rhomboid; cl11446 983545007594 Glutathione-dependent formaldehyde-activating enzyme; Region: GFA; cl01553 983545007595 CsbD-like; Region: CsbD; cl15799 983545007596 Protein of unknown function (DUF419); Region: DUF419; cl15265 983545007597 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cl00309 983545007598 lipoprotein releasing system, transmembrane protein, LolC/E family; Region: lolCE; TIGR02212 983545007599 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 983545007600 PilZ domain; Region: PilZ; cl01260 983545007601 transcription-repair coupling factor; Provisional; Region: PRK10689 983545007602 CarD-like/TRCF domain; Region: CarD_CdnL_TRCF; cl00588 983545007603 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 983545007604 ATP binding site [chemical binding]; other site 983545007605 putative Mg++ binding site [ion binding]; other site 983545007606 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 983545007607 nucleotide binding region [chemical binding]; other site 983545007608 ATP-binding site [chemical binding]; other site 983545007609 TRCF domain; Region: TRCF; cl04088 983545007610 Protein of unknown function (DUF2803); Region: DUF2803; pfam10972 983545007611 Protein of unknown function (DUF2803); Region: DUF2803; pfam10972 983545007612 Protein of unknown function (DUF2803); Region: DUF2803; pfam10972 983545007613 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 983545007614 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl00284 983545007615 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl00284 983545007616 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_3; cd06151 983545007617 homotrimer interaction site [polypeptide binding]; other site 983545007618 putative active site [active] 983545007619 Cytochrome c; Region: Cytochrom_C; cl11414 983545007620 Cytochrome c; Region: Cytochrom_C; cl11414 983545007621 Monoamine oxidase [Amino acid transport and metabolism]; Region: COG1231 983545007622 Transcriptional regulator [Transcription]; Region: LysR; COG0583 983545007623 Helix-turn-helix domains; Region: HTH; cl00088 983545007624 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 983545007625 dimerization interface [polypeptide binding]; other site 983545007626 Domain of unknown function (DUF1805); Region: DUF1805; cl01339 983545007627 Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115 983545007628 transmembrane helices; other site 983545007629 Citrate transporter; Region: CitMHS; pfam03600 983545007630 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971 983545007631 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; cl01255 983545007632 recombination and repair protein; Provisional; Region: PRK10869 983545007633 RecN ATPase involved in DNA repair; ABC (ATP-binding cassette) transporter nucleotide-binding domain; ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds including sugars, ions, peptides, and...; Region: ABC_RecN; cd03241 983545007634 Walker A/P-loop; other site 983545007635 ATP binding site [chemical binding]; other site 983545007636 Q-loop/lid; other site 983545007637 RecN ATPase involved in DNA repair; ABC (ATP-binding cassette) transporter nucleotide-binding domain; ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds including sugars, ions, peptides, and...; Region: ABC_RecN; cd03241 983545007638 ABC transporter signature motif; other site 983545007639 Walker B; other site 983545007640 D-loop; other site 983545007641 H-loop/switch region; other site 983545007642 SmpA / OmlA family; Region: SmpA_OmlA; cl01095 983545007643 ABC transporter ATP-binding protein; Provisional; Region: PRK15064 983545007644 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 983545007645 Walker A/P-loop; other site 983545007646 ATP binding site [chemical binding]; other site 983545007647 Q-loop/lid; other site 983545007648 ABC transporter signature motif; other site 983545007649 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 983545007650 Walker B; other site 983545007651 D-loop; other site 983545007652 H-loop/switch region; other site 983545007653 ABC transporter; Region: ABC_tran_2; pfam12848 983545007654 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 983545007655 LabA_like proteins; Region: LabA_like/DUF88; cl10034 983545007656 putative metal binding site [ion binding]; other site 983545007657 Fe2+ transport system protein B [Inorganic ion transport and metabolism]; Region: FeoB; COG0370 983545007658 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 983545007659 G1 box; other site 983545007660 GTP/Mg2+ binding site [chemical binding]; other site 983545007661 G2 box; other site 983545007662 Switch I region; other site 983545007663 G3 box; other site 983545007664 Switch II region; other site 983545007665 G4 box; other site 983545007666 G5 box; other site 983545007667 Nucleoside recognition; Region: Gate; cl00486 983545007668 Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664 983545007669 Nucleoside recognition; Region: Gate; cl00486 983545007670 FeoA domain; Region: FeoA; cl00838 983545007671 Class-II DAHP synthetase family; Region: DAHP_synth_2; cl03230 983545007672 Low molecular weight phosphatase family; Region: LMWPc; cd00115 983545007673 Low molecular weight phosphotyrosine protein phosphatase; Region: LMWPc; pfam01451 983545007674 active site 983545007675 paraquat-inducible membrane protein A; Provisional; Region: PRK15103 983545007676 Paraquat-inducible protein A; Region: PqiA; pfam04403 983545007677 Paraquat-inducible protein A; Region: PqiA; pfam04403 983545007678 paraquat-inducible protein B; Provisional; Region: PRK10807 983545007679 mce related protein; Region: MCE; pfam02470 983545007680 mce related protein; Region: MCE; pfam02470 983545007681 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3009 983545007682 Protein of unknown function (DUF330); Region: DUF330; cl01135 983545007683 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859 983545007684 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 983545007685 metal binding site [ion binding]; metal-binding site 983545007686 active site 983545007687 I-site; other site 983545007688 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 983545007689 ABC-type transport system involved in Fe-S cluster assembly, permease and ATPase components [Posttranslational modification, protein turnover, chaperones]; Region: ATM1; COG5265 983545007690 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 983545007691 Walker A/P-loop; other site 983545007692 ATP binding site [chemical binding]; other site 983545007693 Q-loop/lid; other site 983545007694 ABC transporter signature motif; other site 983545007695 Walker B; other site 983545007696 D-loop; other site 983545007697 H-loop/switch region; other site 983545007698 Protein of unknown function (DUF3820); Region: DUF3820; cl01411 983545007699 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 983545007700 16S/18S rRNA binding site [nucleotide binding]; other site 983545007701 S13e-L30e interaction site [polypeptide binding]; other site 983545007702 25S rRNA binding site [nucleotide binding]; other site 983545007703 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK05033 983545007704 PseudoU_synth_EcTruB: Pseudouridine synthase, Escherichia coli TruB like. This group consists of bacterial pseudouridine synthases similar to E. coli TruB and Mycobacterium tuberculosis TruB. Pseudouridine synthases catalyze the isomerization of specific...; Region: PseudoU_synth_EcTruB; cd02573 983545007705 RNA binding site [nucleotide binding]; other site 983545007706 active site 983545007707 Ribosome-binding factor A; Region: RBFA; cl00542 983545007708 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 983545007709 Bacterial translation initiation factor IF-2 associated region; Region: IF2_assoc; pfam08364 983545007710 translation initiation factor IF-2; Region: IF-2; TIGR00487 983545007711 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 983545007712 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 983545007713 G1 box; other site 983545007714 putative GEF interaction site [polypeptide binding]; other site 983545007715 GTP/Mg2+ binding site [chemical binding]; other site 983545007716 Switch I region; other site 983545007717 G2 box; other site 983545007718 G3 box; other site 983545007719 Switch II region; other site 983545007720 G4 box; other site 983545007721 G5 box; other site 983545007722 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 983545007723 Translation-initiation factor 2; Region: IF-2; pfam11987 983545007724 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 983545007725 transcription elongation factor NusA; Validated; Region: nusA; PRK09202 983545007726 NusA N-terminal domain; Region: NusA_N; pfam08529 983545007727 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 983545007728 RNA binding site [nucleotide binding]; other site 983545007729 homodimer interface [polypeptide binding]; other site 983545007730 K homology RNA-binding domain, type I. KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains that...; Region: KH-I; cl00098 983545007731 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 983545007732 G-X-X-G motif; other site 983545007733 transcription termination factor NusA, C-terminal duplication; Region: nusA_Cterm_rpt; TIGR01954 983545007734 ribosome maturation protein RimP; Reviewed; Region: PRK00092 983545007735 The eukaryotic Sm and Sm-like (LSm) proteins associate with RNA to form the core domain of the ribonucleoprotein particles involved in a variety of RNA processing events including pre-mRNA splicing, telomere replication, and mRNA degradation. Members of...; Region: Sm_like; cl00259 983545007736 The eukaryotic Sm and Sm-like (LSm) proteins associate with RNA to form the core domain of the ribonucleoprotein particles involved in a variety of RNA processing events including pre-mRNA splicing, telomere replication, and mRNA degradation. Members of...; Region: Sm_like; cl00259 983545007737 Sm1 motif; other site 983545007738 D3 - B interaction site; other site 983545007739 D1 - D2 interaction site; other site 983545007740 Hfq - Hfq interaction site; other site 983545007741 RNA binding pocket [nucleotide binding]; other site 983545007742 Sm2 motif; other site 983545007743 PCD_DCoH: The bifunctional protein pterin-4alpha-carbinolamine dehydratase (PCD), also known as DCoH (dimerization cofactor of hepatocyte nuclear factor-1), is both a transcription activator and a metabolic enzyme. DCoH stimulates gene expression by...; Region: PCD_DCoH_subfamily_b; cd00914 983545007744 aromatic arch; other site 983545007745 DCoH dimer interaction site [polypeptide binding]; other site 983545007746 DCoH /HNF-1 dimer interaction site [polypeptide binding]; other site 983545007747 DCoH tetramer interaction site [polypeptide binding]; other site 983545007748 substrate binding site [chemical binding]; other site 983545007749 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl00284 983545007750 TonB-dependent receptor; Region: TonB-Xanth-Caul; TIGR01782 983545007751 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl00284 983545007752 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 983545007753 active site 2 [active] 983545007754 active site 1 [active] 983545007755 Peptidase family M23; Region: Peptidase_M23; pfam01551 983545007756 acyl-CoA dehydrogenase; Reviewed; Region: PRK13026 983545007757 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 983545007758 active site 983545007759 Domain of unknown function (DUF1974); Region: DUF1974; pfam09317 983545007760 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 983545007761 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 983545007762 catalytic residue [active] 983545007763 galactonate dehydratase; Provisional; Region: PRK14017 983545007764 Mandelate racemase (MR)-like subfamily of the enolase superfamily. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved catalytic residues; Region: MR_like; cd03316 983545007765 active site pocket [active] 983545007766 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cl00214 983545007767 intersubunit interface [polypeptide binding]; other site 983545007768 active site 983545007769 Zn2+ binding site [ion binding]; other site 983545007770 PPIC-type PPIASE domain; Region: Rotamase; cl08278 983545007771 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy; cl15773 983545007772 7TM diverse intracellular signalling; Region: 7TMR-DISM_7TM; pfam07695 983545007773 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 983545007774 metal binding site [ion binding]; metal-binding site 983545007775 active site 983545007776 I-site; other site 983545007777 Predicted acyltransferase [General function prediction only]; Region: COG4801 983545007778 M28 Zn-Peptidase Aeromonas (Vibrio) proteolytica aminopeptidase (AAP)-like; Region: M28_AAP_like; cd05642 983545007779 putative metal binding site [ion binding]; other site 983545007780 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 983545007781 Interdomain contacts; other site 983545007782 Cytokine receptor motif; other site 983545007783 DoxX; Region: DoxX; cl00976 983545007784 Cupin domain; Region: Cupin_2; cl09118 983545007785 Helix-turn-helix domains; Region: HTH; cl00088 983545007786 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11074 983545007787 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 983545007788 dimerization interface [polypeptide binding]; other site 983545007789 Prostaglandin dehydrogenases; Region: PGDH; cd05288 983545007790 Putative NADP-dependent oxidoreductases [General function prediction only]; Region: COG2130 983545007791 NAD(P) binding site [chemical binding]; other site 983545007792 substrate binding site [chemical binding]; other site 983545007793 dimer interface [polypeptide binding]; other site 983545007794 Transcriptional regulator [Transcription]; Region: LysR; COG0583 983545007795 Helix-turn-helix domains; Region: HTH; cl00088 983545007796 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 983545007797 putative effector binding pocket; other site 983545007798 dimerization interface [polypeptide binding]; other site 983545007799 family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187 983545007800 Uncharacterized protein family UPF0052; Region: UPF0052; pfam01933 983545007801 phosphate binding site [ion binding]; other site 983545007802 putative substrate binding pocket [chemical binding]; other site 983545007803 dimer interface [polypeptide binding]; other site 983545007804 Modulator of Rho-dependent transcription termination (ROF); Region: ROF; cl09210 983545007805 signal recognition particle protein; Provisional; Region: PRK10867 983545007806 SRP54-type protein, helical bundle domain; Region: SRP54_N; cl03758 983545007807 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 983545007808 P loop; other site 983545007809 GTP binding site [chemical binding]; other site 983545007810 Signal peptide binding domain; Region: SRP_SPB; pfam02978 983545007811 Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504 983545007812 hypothetical protein; Provisional; Region: PRK11573 983545007813 Domain of unknown function DUF21; Region: DUF21; pfam01595 983545007814 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 983545007815 Transporter associated domain; Region: CorC_HlyC; cl08393 983545007816 Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP; cd07040 983545007817 catalytic core [active] 983545007818 Secreted/periplasmic Zn-dependent peptidases, insulinase-like [Posttranslational modification, protein turnover, chaperones]; Region: Ptr; COG1025 983545007819 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 983545007820 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 983545007821 Predicted periplasmic ligand-binding sensor domain [Signal transduction mechanisms]; Region: COG3292 983545007822 Y_Y_Y domain; Region: Y_Y_Y; pfam07495 983545007823 PAS fold; Region: PAS_3; pfam08447 983545007824 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 983545007825 PAS domain; Region: PAS_9; pfam13426 983545007826 putative active site [active] 983545007827 heme pocket [chemical binding]; other site 983545007828 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 983545007829 metal binding site [ion binding]; metal-binding site 983545007830 active site 983545007831 I-site; other site 983545007832 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 983545007833 multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadJ; PRK11154 983545007834 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 983545007835 substrate binding site [chemical binding]; other site 983545007836 oxyanion hole (OAH) forming residues; other site 983545007837 trimer interface [polypeptide binding]; other site 983545007838 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 983545007839 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 983545007840 3-ketoacyl-CoA thiolase; Reviewed; Region: fadI; PRK08963 983545007841 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 983545007842 dimer interface [polypeptide binding]; other site 983545007843 active site 983545007844 MoxR-like ATPases [General function prediction only]; Region: COG0714 983545007845 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 983545007846 Walker A motif; other site 983545007847 ATP binding site [chemical binding]; other site 983545007848 Walker B motif; other site 983545007849 arginine finger; other site 983545007850 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 983545007851 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 983545007852 Domain of unknown function (DUF4381); Region: DUF4381; pfam14316 983545007853 VWA BatA type: Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b...; Region: vWA_BatA_type; cd01467 983545007854 metal ion-dependent adhesion site (MIDAS); other site 983545007855 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 983545007856 metal ion-dependent adhesion site (MIDAS); other site 983545007857 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 983545007858 Oxygen tolerance; Region: BatD; pfam13584 983545007859 RNA polymerase sigma factor; Provisional; Region: PRK12517 983545007860 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 983545007861 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 983545007862 DNA binding residues [nucleotide binding] 983545007863 Protein of unknown function (DUF3379); Region: DUF3379; pfam11859 983545007864 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 983545007865 Sodium:solute symporter family; Region: SSF; cl00456 983545007866 Predicted signal transduction protein containing EAL and modified HD-GYP domains [Signal transduction mechanisms]; Region: COG3434 983545007867 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cl00290 983545007868 sulfate adenylyltransferase, small subunit; Region: CysD; TIGR02039 983545007869 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 983545007870 Active Sites [active] 983545007871 Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically 'activated' sulfate form important for the assimilation of...; Region: APSK; cd02027 983545007872 Gluconate kinase [Carbohydrate transport and metabolism]; Region: GntK; COG3265 983545007873 ligand-binding site [chemical binding]; other site 983545007874 CysQ, a 3'-Phosphoadenosine-5'-phosphosulfate (PAPS) 3'-phosphatase, is a bacterial member of the inositol monophosphatase family. It has been proposed that CysQ helps control intracellular levels of PAPS, which is an intermediate in cysteine...; Region: CysQ; cd01638 983545007875 active site 983545007876 sulfate adenylyltransferase subunit 1; Provisional; Region: cysN; PRK05124 983545007877 CysN, together with protein CysD, forms the ATP sulfurylase (ATPS) complex; Region: CysN_ATPS; cd04166 983545007878 CysD dimerization site [polypeptide binding]; other site 983545007879 G1 box; other site 983545007880 putative GEF interaction site [polypeptide binding]; other site 983545007881 GTP/Mg2+ binding site [chemical binding]; other site 983545007882 Switch I region; other site 983545007883 G2 box; other site 983545007884 G3 box; other site 983545007885 Switch II region; other site 983545007886 G4 box; other site 983545007887 G5 box; other site 983545007888 CysN_NodQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NodQ_II; cd03695 983545007889 TCysN_NoDQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NoDQ_III; cd04095 983545007890 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl15357 983545007891 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl15357 983545007892 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl15357 983545007893 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl15357 983545007894 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 983545007895 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 983545007896 RNA binding surface [nucleotide binding]; other site 983545007897 PseudoU_synth_RluF_like: Pseudouridine synthase, Escherichia coli RluF like. This group is comprised of bacterial proteins similar to Escherichia coli RluF. Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to...; Region: PseudoU_synth_RluF; cd02554 983545007898 probable active site [active] 983545007899 Domain of Unknown Function (DUF349); Region: DUF349; pfam03993 983545007900 Domain of Unknown Function (DUF349); Region: DUF349; pfam03993 983545007901 Protein of unknown function (DUF1315); Region: DUF1315; cl01215 983545007902 zinc-ribbon domain; Region: zf-ribbon_3; cl11198 983545007903 Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548 983545007904 Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548 983545007905 Predicted carboxypeptidase [Amino acid transport and metabolism]; Region: COG2866 983545007906 M14 family of metallocarboxypeptidases and related proteins; Region: Peptidase_M14_like; cl11393 983545007907 active site 983545007908 Zn binding site [ion binding]; other site 983545007909 glyceraldehyde-3-phosphate dehydrogenase; Reviewed; Region: PRK08289 983545007910 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 983545007911 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; cl15856 983545007912 Protein of unknown function (DUF2989); Region: DUF2989; pfam11207 983545007913 methionine sulfoxide reductase B; Provisional; Region: PRK00222; cl15841 983545007914 SelR domain; Region: SelR; pfam01641 983545007915 glycogen debranching enzyme GlgX; Region: glgX_debranch; TIGR02100 983545007916 N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856 983545007917 Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326 983545007918 active site 983545007919 catalytic site [active] 983545007920 glycogen branching enzyme; Provisional; Region: PRK05402 983545007921 N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855 983545007922 Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322 983545007923 active site 983545007924 catalytic site [active] 983545007925 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; cl02706 983545007926 4-alpha-glucanotransferase; Provisional; Region: malQ; PRK11052 983545007927 4-alpha-glucanotransferase; Region: Glyco_hydro_77; cl00711 983545007928 glyceraldehyde-3-phosphate dehydrogenase A; Provisional; Region: gapA; PRK15425 983545007929 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 983545007930 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; cl15856 983545007931 D-hexose-6-phosphate epimerase-like; Region: D-hex-6-P-epi_like; cd09020 983545007932 active site 983545007933 phosphate binding residues; other site 983545007934 catalytic residues [active] 983545007935 polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824 983545007936 Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363 983545007937 RNase E interface [polypeptide binding]; other site 983545007938 trimer interface [polypeptide binding]; other site 983545007939 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 983545007940 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 983545007941 RNase E interface [polypeptide binding]; other site 983545007942 trimer interface [polypeptide binding]; other site 983545007943 active site 983545007944 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 983545007945 putative nucleic acid binding region [nucleotide binding]; other site 983545007946 G-X-X-G motif; other site 983545007947 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 983545007948 RNA binding site [nucleotide binding]; other site 983545007949 domain interface; other site 983545007950 Pectinacetylesterase; Region: PAE; pfam03283 983545007951 PseudoU_synth_RsuA/RluD: Pseudouridine synthase, RsuA/RluD family. This group is comprised of eukaryotic, bacterial and archeal proteins similar to eight site specific Escherichia coli pseudouridine synthases: RsuA, RluA, RluB, RluC, RluD, RluE, RluF and...; Region: PseudoU_synth_RluCD_like; cd02869 983545007952 active site 983545007953 DNA recombination protein RmuC; Provisional; Region: PRK10361 983545007954 RmuC family; Region: RmuC; pfam02646 983545007955 Fumarate hydratase (Fumerase); Region: Fumerase; cl00851 983545007956 Fumarase C-terminus; Region: Fumerase_C; cl00795 983545007957 aminodeoxychorismate synthase subunit I; Provisional; Region: pabB; PRK15465 983545007958 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 983545007959 chorismate binding enzyme; Region: Chorismate_bind; cl10555 983545007960 Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426 983545007961 putative active site [active] 983545007962 putative CoA binding site [chemical binding]; other site 983545007963 nudix motif; other site 983545007964 metal binding site [ion binding]; metal-binding site 983545007965 L-serine dehydratase, iron-sulfur-dependent, single chain form; Region: sda_mono; TIGR00720 983545007966 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 983545007967 Serine dehydratase alpha chain; Region: SDH_alpha; cl12120 983545007968 transcriptional regulator CysB; Reviewed; Region: cysB; PRK12681 983545007969 Helix-turn-helix domains; Region: HTH; cl00088 983545007970 The C-terminal substrate domain of LysR-type transcriptional regulators CysB-like contains type 2 periplasmic binding fold; Region: PBP2_CysB_like; cd08413 983545007971 substrate binding site [chemical binding]; other site 983545007972 dimerization interface [polypeptide binding]; other site 983545007973 Osmosensitive K+ channel histidine kinase [Signal transduction mechanisms]; Region: KdpD; COG2205 983545007974 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 983545007975 ATP binding site [chemical binding]; other site 983545007976 Mg2+ binding site [ion binding]; other site 983545007977 G-X-G motif; other site 983545007978 Transcriptional regulator [Transcription]; Region: LysR; COG0583 983545007979 Helix-turn-helix domains; Region: HTH; cl00088 983545007980 TThe C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_4; cd08440 983545007981 putative dimerization interface [polypeptide binding]; other site 983545007982 SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339 983545007983 SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339 983545007984 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 983545007985 DEAD-like helicases superfamily; Region: DEXDc; smart00487 983545007986 ATP binding site [chemical binding]; other site 983545007987 Mg++ binding site [ion binding]; other site 983545007988 motif III; other site 983545007989 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 983545007990 nucleotide binding region [chemical binding]; other site 983545007991 ATP-binding site [chemical binding]; other site 983545007992 Nitroreductase-like family which includes NADH oxidase and arsenite oxidiase. NADH oxidase catalyses the oxidation of NAD(P)H and accepts a wide broad range of compounds as electron acceptors, such as nitrocompound. Arsenite oxidase in a...; Region: Arsenite_oxidase; cd02135 983545007993 putative FMN binding site [chemical binding]; other site 983545007994 DoxX; Region: DoxX; cl00976 983545007995 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 983545007996 active site 983545007997 motif I; other site 983545007998 motif II; other site 983545007999 dUMP phosphatase; Provisional; Region: PRK09449 983545008000 MiaE tRNA-modifying nonheme diiron monooxygenase, ferritin-like diiron-binding domain; Region: MiaE; cd07910 983545008001 active site 983545008002 dinuclear metal binding site [ion binding]; other site 983545008003 dimerization interface [polypeptide binding]; other site 983545008004 Yip1 domain; Region: Yip1; cl12048 983545008005 amidophosphoribosyltransferase; Provisional; Region: PRK09246 983545008006 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 983545008007 active site 983545008008 tetramer interface [polypeptide binding]; other site 983545008009 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 983545008010 active site 983545008011 Colicin V production protein; Region: Colicin_V; cl00567 983545008012 Uncharacterized protein conserved in bacteria [Function unknown]; Region: DedD; COG3147 983545008013 Sporulation related domain; Region: SPOR; cl10051 983545008014 bifunctional folylpolyglutamate synthase/ dihydrofolate synthase; Provisional; Region: PRK10846 983545008015 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 983545008016 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 983545008017 acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654 983545008018 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl15772 983545008019 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 983545008020 PseudoU_synth_EcTruA: Pseudouridine synthase, Escherichia coli TruA like. This group consists of eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA, Pseudomonas aeruginosa truA and human pseudouridine synthase-like 1 (PUSL1); Region: PseudoU_synth_EcTruA; cd02570 983545008021 dimerization interface 3.5A [polypeptide binding]; other site 983545008022 active site 983545008023 response regulator GlrR; Provisional; Region: PRK15115 983545008024 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 983545008025 active site 983545008026 phosphorylation site [posttranslational modification] 983545008027 intermolecular recognition site; other site 983545008028 dimerization interface [polypeptide binding]; other site 983545008029 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 983545008030 Walker A motif; other site 983545008031 ATP binding site [chemical binding]; other site 983545008032 Walker B motif; other site 983545008033 arginine finger; other site 983545008034 Helix-turn-helix domains; Region: HTH; cl00088 983545008035 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 983545008036 Osmosensitive K+ channel histidine kinase [Signal transduction mechanisms]; Region: KdpD; COG2205 983545008037 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 983545008038 ATP binding site [chemical binding]; other site 983545008039 Mg2+ binding site [ion binding]; other site 983545008040 G-X-G motif; other site 983545008041 EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to...; Region: EFh; cl08302 983545008042 tellurium resistance terB-like protein, subgroup 2; Region: terB_like_2; cd07313 983545008043 putative metal binding site [ion binding]; other site 983545008044 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 983545008045 ABC Carbohydrate and Solute Transporters-like subgroup. This family is comprised of proteins involved in the transport of apparently unrelated solutes and proteins specific for di- and oligosaccharides and polyols. ABC transporters are a large family...; Region: ABC_Carb_Solutes_like; cd03259 983545008046 Walker A/P-loop; other site 983545008047 ATP binding site [chemical binding]; other site 983545008048 Q-loop/lid; other site 983545008049 ABC transporter signature motif; other site 983545008050 Walker B; other site 983545008051 D-loop; other site 983545008052 H-loop/switch region; other site 983545008053 TOBE domain; Region: TOBE_2; cl01440 983545008054 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 983545008055 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 983545008056 dimer interface [polypeptide binding]; other site 983545008057 conserved gate region; other site 983545008058 putative PBP binding loops; other site 983545008059 ABC-ATPase subunit interface; other site 983545008060 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 983545008061 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 983545008062 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 983545008063 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 983545008064 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 983545008065 Coenzyme A binding pocket [chemical binding]; other site 983545008066 Response regulator receiver domain; Region: Response_reg; pfam00072 983545008067 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 983545008068 active site 983545008069 phosphorylation site [posttranslational modification] 983545008070 intermolecular recognition site; other site 983545008071 dimerization interface [polypeptide binding]; other site 983545008072 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cl00120 983545008073 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 983545008074 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 983545008075 anti sigma factor interaction site; other site 983545008076 regulatory phosphorylation site [posttranslational modification]; other site 983545008077 translation initiation factor Sui1; Validated; Region: PRK06824 983545008078 The SUI1/eIF1 (eukaryotic initiation factor 1) fold is found in eukaryotes, archaea, and some bacteria and is thought to play an important role in accurate initiator codon recognition during translation initiation. This fold, which includes two...; Region: SUI1_eIF1; cd00474 983545008079 Predicted RNA interaction site [nucleotide binding]; other site 983545008080 putative binding site; other site 983545008081 Mutations affecting start-site selection; other site 983545008082 Response regulator receiver domain; Region: Response_reg; pfam00072 983545008083 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 983545008084 active site 983545008085 phosphorylation site [posttranslational modification] 983545008086 intermolecular recognition site; other site 983545008087 dimerization interface [polypeptide binding]; other site 983545008088 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 983545008089 active site 983545008090 phosphorylation site [posttranslational modification] 983545008091 intermolecular recognition site; other site 983545008092 dimerization interface [polypeptide binding]; other site 983545008093 bifunctional chorismate mutase/prephenate dehydratase; Provisional; Region: pheA; PRK10622 983545008094 Chorismate mutase type II; Region: CM_2; cl00693 983545008095 Prephenate dehydratase; Region: PDT; pfam00800 983545008096 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 983545008097 putative L-Phe binding site [chemical binding]; other site 983545008098 Protein of unknown function (DUF1275); Region: DUF1275; cl01453 983545008099 bifunctional chorismate mutase/prephenate dehydrogenase; Provisional; Region: tyrA; PRK11199 983545008100 Chorismate mutase type II; Region: CM_2; cl00693 983545008101 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 983545008102 NeuB family; Region: NeuB; cl00496 983545008103 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 983545008104 Zn-dependent oligopeptidases [Amino acid transport and metabolism]; Region: Dcp; COG0339 983545008105 Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456 983545008106 active site 983545008107 Zn binding site [ion binding]; other site 983545008108 maltose O-acetyltransferase; Provisional; Region: PRK10092 983545008109 Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357 983545008110 active site 983545008111 substrate binding site [chemical binding]; other site 983545008112 trimer interface [polypeptide binding]; other site 983545008113 CoA binding site [chemical binding]; other site 983545008114 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl15754 983545008115 Protein of unknown function (DUF890); Region: Methyltransf_10; pfam05971 983545008116 redox-sensitive transcriptional activator SoxR; Region: SoxR; TIGR01950 983545008117 Helix-Turn-Helix DNA binding domain of the SoxR transcription regulator; Region: HTH_SoxR; cd01110 983545008118 DNA binding residues [nucleotide binding] 983545008119 dimer interface [polypeptide binding]; other site 983545008120 [2Fe-2S] cluster binding site [ion binding]; other site 983545008121 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 983545008122 active site 983545008123 metal binding site [ion binding]; metal-binding site 983545008124 Ribosomal protein L19; Region: Ribosomal_L19; cl00406 983545008125 tRNA (Guanine-1)-methyltransferase; Region: tRNA_m1G_MT; cl00407 983545008126 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 983545008127 RimM N-terminal domain; Region: RimM; pfam01782 983545008128 Photosynthetic reaction center (RC) complex, subunit H; RC is an integral membrane protein-pigment complex which catalyzes light-induced reduction of ubiquinone to ubiquinol, generating a transmembrane electrochemical gradient of protons used to produce...; Region: PRCH; cl09959 983545008129 Ribosomal protein S16; Region: Ribosomal_S16; cl00368 983545008130 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 983545008131 ABC Carbohydrate and Solute Transporters-like subgroup. This family is comprised of proteins involved in the transport of apparently unrelated solutes and proteins specific for di- and oligosaccharides and polyols. ABC transporters are a large family...; Region: ABC_Carb_Solutes_like; cd03259 983545008132 Walker A/P-loop; other site 983545008133 ATP binding site [chemical binding]; other site 983545008134 Q-loop/lid; other site 983545008135 ABC transporter signature motif; other site 983545008136 Walker B; other site 983545008137 D-loop; other site 983545008138 H-loop/switch region; other site 983545008139 Preprotein translocase SecG subunit; Region: SecG; cl09123 983545008140 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 983545008141 substrate binding site [chemical binding]; other site 983545008142 dimer interface [polypeptide binding]; other site 983545008143 catalytic triad [active] 983545008144 phosphoglucosamine mutase; Provisional; Region: glmM; PRK10887 983545008145 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 983545008146 active site 983545008147 substrate binding site [chemical binding]; other site 983545008148 metal binding site [ion binding]; metal-binding site 983545008149 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 983545008150 dihydropteroate synthase; Region: DHPS; TIGR01496 983545008151 substrate binding pocket [chemical binding]; other site 983545008152 dimer interface [polypeptide binding]; other site 983545008153 inhibitor binding site; inhibition site 983545008154 ATP-dependent metalloprotease; Reviewed; Region: hflB; PRK10733 983545008155 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 983545008156 Walker A motif; other site 983545008157 ATP binding site [chemical binding]; other site 983545008158 Walker B motif; other site 983545008159 arginine finger; other site 983545008160 Peptidase family M41; Region: Peptidase_M41; pfam01434 983545008161 23S rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: FtsJ; COG0293 983545008162 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 983545008163 S-adenosylmethionine binding site [chemical binding]; other site 983545008164 CRS1 / YhbY (CRM) domain; Region: CRS1_YhbY; cl00663 983545008165 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; cl11587 983545008166 AAA domain; Region: AAA_32; pfam13654 983545008167 ATP-dependent protease Lon; Provisional; Region: PRK13765 983545008168 Subunit ChlI of Mg-chelatase; Region: ChlI; cl12214 983545008169 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 983545008170 hydrophobic ligand binding site; other site 983545008171 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 983545008172 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 983545008173 HIGH motif; other site 983545008174 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 983545008175 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 983545008176 active site 983545008177 KMSKS motif; other site 983545008178 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 983545008179 tRNA binding surface [nucleotide binding]; other site 983545008180 Lipopolysaccharide-assembly; Region: LptE; cl01125 983545008181 DNA polymerase III subunit delta; Reviewed; Region: holA; PRK05574 983545008182 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 983545008183 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 983545008184 nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071 983545008185 active site 983545008186 (T/H)XGH motif; other site 983545008187 Oligomerisation domain; Region: Oligomerisation; cl00519 983545008188 Uncharacterized conserved protein [Function unknown]; Region: COG1576; cl00679 983545008189 Predicted SPOUT methyltransferase; Region: SPOUT_MTase; pfam02590 983545008190 penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423 983545008191 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 983545008192 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 983545008193 Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511 983545008194 Transglycosylase SLT domain; Region: SLT_2; pfam13406 983545008195 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic 'goose-type' lysozymes (GEWL). LTs catalyze...; Region: LT_GEWL; cd00254 983545008196 N-acetyl-D-glucosamine binding site [chemical binding]; other site 983545008197 catalytic residue [active] 983545008198 Lipoproteins [Cell envelope biogenesis, outer membrane]; Region: RlpA; COG0797 983545008199 Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; cl04011 983545008200 Sporulation related domain; Region: SPOR; cl10051 983545008201 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 983545008202 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 983545008203 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; cl06814 983545008204 Protein of unknown function (DUF493); Region: DUF493; cl01102 983545008205 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 983545008206 lipoyl synthase; Provisional; Region: PRK05481 983545008207 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 983545008208 FeS/SAM binding site; other site 983545008209 Cupin superfamily (DUF985); Region: Cupin_5; cl01418 983545008210 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 983545008211 metal binding site [ion binding]; metal-binding site 983545008212 active site 983545008213 I-site; other site 983545008214 Protein of unknown function (DUF1255); Region: DUF1255; cl01202 983545008215 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 983545008216 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 983545008217 Type I (cytosolic) bacterial L-asparaginase; Region: L-asparaginase_I; cd08963 983545008218 active site 983545008219 homodimer interface [polypeptide binding]; other site 983545008220 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box protein; Region: CSP_CDS; cd04458 983545008221 DNA-binding site [nucleotide binding]; DNA binding site 983545008222 RNA-binding motif; other site 983545008223 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 983545008224 Major Facilitator Superfamily; Region: MFS_1; pfam07690 983545008225 putative substrate translocation pore; other site 983545008226 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 983545008227 Tetramer interface [polypeptide binding]; other site 983545008228 active site 983545008229 FMN-binding site [chemical binding]; other site 983545008230 HemK family putative methylases; Region: hemK_fam; TIGR00536 983545008231 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 983545008232 S-adenosylmethionine binding site [chemical binding]; other site 983545008233 hypothetical protein; Provisional; Region: PRK04946 983545008234 Smr domain; Region: Smr; cl02619 983545008235 Response regulator receiver domain; Region: Response_reg; pfam00072 983545008236 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 983545008237 active site 983545008238 phosphorylation site [posttranslational modification] 983545008239 intermolecular recognition site; other site 983545008240 dimerization interface [polypeptide binding]; other site 983545008241 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 983545008242 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 983545008243 DNA binding residues [nucleotide binding] 983545008244 Response regulator receiver domain; Region: Response_reg; pfam00072 983545008245 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 983545008246 active site 983545008247 phosphorylation site [posttranslational modification] 983545008248 intermolecular recognition site; other site 983545008249 dimerization interface [polypeptide binding]; other site 983545008250 NMT1-like family; Region: NMT1_2; cl15260 983545008251 ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; pfam12974 983545008252 Signal transduction histidine kinase, nitrate/nitrite-specific [Signal transduction mechanisms]; Region: NarQ; COG3850 983545008253 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 983545008254 dimerization interface [polypeptide binding]; other site 983545008255 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 983545008256 dimer interface [polypeptide binding]; other site 983545008257 phosphorylation site [posttranslational modification] 983545008258 Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms]; Region: RsbW; COG2172 983545008259 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 983545008260 ATP binding site [chemical binding]; other site 983545008261 Mg2+ binding site [ion binding]; other site 983545008262 G-X-G motif; other site 983545008263 Response regulator containing a CheY-like receiver domain and an HD-GYP domain [Transcription / Signal transduction mechanisms]; Region: COG3437 983545008264 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 983545008265 active site 983545008266 phosphorylation site [posttranslational modification] 983545008267 intermolecular recognition site; other site 983545008268 dimerization interface [polypeptide binding]; other site 983545008269 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 983545008270 Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal transduction mechanisms]; Region: COG4191 983545008271 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 983545008272 dimer interface [polypeptide binding]; other site 983545008273 phosphorylation site [posttranslational modification] 983545008274 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 983545008275 ATP binding site [chemical binding]; other site 983545008276 Mg2+ binding site [ion binding]; other site 983545008277 G-X-G motif; other site 983545008278 Heme NO binding; Region: HNOB; cl15268 983545008279 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain; Region: UDPG_MGDP_dh_N; pfam03721 983545008280 signal transduction histidine-protein kinase BaeS; Provisional; Region: PRK10549 983545008281 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 983545008282 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 983545008283 dimer interface [polypeptide binding]; other site 983545008284 phosphorylation site [posttranslational modification] 983545008285 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 983545008286 ATP binding site [chemical binding]; other site 983545008287 Mg2+ binding site [ion binding]; other site 983545008288 G-X-G motif; other site 983545008289 DNA-binding transcriptional regulator BaeR; Provisional; Region: PRK10710 983545008290 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 983545008291 active site 983545008292 phosphorylation site [posttranslational modification] 983545008293 intermolecular recognition site; other site 983545008294 dimerization interface [polypeptide binding]; other site 983545008295 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 983545008296 DNA binding site [nucleotide binding] 983545008297 YHYH protein; Region: YHYH; pfam14240 983545008298 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl15754 983545008299 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 983545008300 dimer interface [polypeptide binding]; other site 983545008301 ADP-ribose binding site [chemical binding]; other site 983545008302 active site 983545008303 nudix motif; other site 983545008304 metal binding site [ion binding]; metal-binding site 983545008305 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 983545008306 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 983545008307 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 983545008308 DNA binding residues [nucleotide binding] 983545008309 Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712 983545008310 FecR protein; Region: FecR; pfam04773 983545008311 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl00284 983545008312 TonB-dependent receptor; Region: TonB-Xanth-Caul; TIGR01782 983545008313 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl00284 983545008314 M14 family of metallocarboxypeptidases and related proteins; Region: Peptidase_M14_like; cl11393 983545008315 active site 983545008316 Zn binding site [ion binding]; other site 983545008317 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 983545008318 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 983545008319 Actin-like ATPase involved in cell morphogenesis [Cell division and chromosome partitioning]; Region: MreB; COG1077 983545008320 hypothetical protein; Provisional; Region: PRK10039 983545008321 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 983545008322 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 983545008323 FtsX-like permease family; Region: FtsX; cl15850 983545008324 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 983545008325 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 983545008326 Walker A/P-loop; other site 983545008327 ATP binding site [chemical binding]; other site 983545008328 Q-loop/lid; other site 983545008329 ABC transporter signature motif; other site 983545008330 Walker B; other site 983545008331 D-loop; other site 983545008332 H-loop/switch region; other site 983545008333 multidrug resistance protein MdtN; Provisional; Region: PRK10476 983545008334 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 983545008335 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 983545008336 Peptidase M14 Succinylglutamate desuccinylase (ASTE)/aspartoacylase (ASPA)-like; uncharacterized subgroup; Region: M14_ASTE_ASPA_like_1; cd06251 983545008337 Succinylglutamate desuccinylase / Aspartoacylase family; Region: AstE_AspA; pfam04952 983545008338 putative active site [active] 983545008339 Zn binding site [ion binding]; other site 983545008340 ribosomal protein S6 modification protein; Provisional; Region: PRK10446 983545008341 ATP-grasp domain; Region: ATP-grasp_4; cl03087 983545008342 choline dehydrogenase; Validated; Region: PRK02106 983545008343 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 983545008344 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 983545008345 Serine proteases of the peptidase family S9A [Amino acid transport and metabolism]; Region: COG1505 983545008346 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 983545008347 Domain of unknown function (DUF4202); Region: DUF4202; pfam13875 983545008348 Membrane transport protein; Region: Mem_trans; cl09117 983545008349 dipeptidyl carboxypeptidase II; Provisional; Region: PRK10280 983545008350 Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456 983545008351 active site 983545008352 Zn binding site [ion binding]; other site 983545008353 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 983545008354 M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like6; cd05664 983545008355 metal binding site [ion binding]; metal-binding site 983545008356 putative dimer interface [polypeptide binding]; other site 983545008357 DNA-binding transcriptional regulator LysR; Provisional; Region: PRK11013 983545008358 Helix-turn-helix domains; Region: HTH; cl00088 983545008359 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 983545008360 dimerization interface [polypeptide binding]; other site 983545008361 Protein of unknown function (DUF1611); Region: DUF1611; pfam07755 983545008362 L-Ala-D/L-Glu epimerase catalyzes the epimerization of L-Ala-D/L-Glu and other dipeptides. The genomic context and the substrate specificity of characterized members of this family from E.coli and B.subtilis indicates a possible role in the metabolism of...; Region: L-Ala-DL-Glu_epimerase; cd03319 983545008363 L-Ala-D/L-Glu epimerase; Provisional; Region: PRK15129 983545008364 active site 983545008365 HupE / UreJ protein; Region: HupE_UreJ; cl01011 983545008366 Domain of unknown function (DUF4331); Region: DUF4331; pfam14224 983545008367 Domain of unknown function (DUF4331); Region: DUF4331; pfam14224 983545008368 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5343 983545008369 Anti-sigma-K factor rskA; Region: RskA; pfam10099 983545008370 RNA polymerase sigma factor; Provisional; Region: PRK12514 983545008371 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 983545008372 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 983545008373 DNA binding residues [nucleotide binding] 983545008374 Membrane glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: MdoH; COG2943 983545008375 Glucan_BSP_ModH catalyzes the elongation of beta-1,2 polyglucose chains of glucan; Region: Glucan_BSP_ModH; cd04191 983545008376 Ligand binding site; other site 983545008377 DXD motif; other site 983545008378 glucan biosynthesis protein G; Provisional; Region: mdoG; PRK13274 983545008379 Periplasmic glucan biosynthesis protein, MdoG; Region: MdoG; cl15433 983545008380 fatty acid metabolism regulator; Provisional; Region: PRK04984 983545008381 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 983545008382 DNA-binding site [nucleotide binding]; DNA binding site 983545008383 FCD domain; Region: FCD; cl11656 983545008384 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl15357 983545008385 transmembrane helices; other site 983545008386 Disulfide bond formation protein DsbB; Region: DsbB; cl00649 983545008387 Amidinotransferase; Region: Amidinotransf; cl12043 983545008388 ornithine cyclodeaminase; Validated; Region: PRK07589 983545008389 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 983545008390 Helix-turn-helix domains; Region: HTH; cl00088 983545008391 Uncharacterized protein related to deoxyribodipyrimidine photolyase [General function prediction only]; Region: COG3046 983545008392 Deoxyribodipyrimidine photo-lyase-related protein; Region: DPRP; pfam04244 983545008393 FAD binding domain of DNA photolyase; Region: FAD_binding_7; pfam03441 983545008394 Flagellin N-methylase; Region: FliB; cl00497 983545008395 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 983545008396 Transglycosylase SLT domain; Region: SLT_2; pfam13406 983545008397 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic 'goose-type' lysozymes (GEWL). LTs catalyze...; Region: LT_GEWL; cd00254 983545008398 N-acetyl-D-glucosamine binding site [chemical binding]; other site 983545008399 YcgL domain; Region: YcgL; cl01189 983545008400 ribonuclease D; Provisional; Region: PRK10829 983545008401 DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142 983545008402 putative active site [active] 983545008403 catalytic site [active] 983545008404 putative substrate binding site [chemical binding]; other site 983545008405 HRDC domain; Region: HRDC; cl02578 983545008406 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK08974 983545008407 AMP-binding enzyme; Region: AMP-binding; cl15778 983545008408 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 983545008409 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 983545008410 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 983545008411 Outer membrane lipoprotein Slp family; Region: Slp; cl01164 983545008412 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl14000 983545008413 Glycoprotease family; Region: Peptidase_M22; pfam00814 983545008414 Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199 983545008415 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 983545008416 Alpha amylase catalytic domain found in archaeal and bacterial Alpha-amylases (also called 1,4-alpha-D-glucan-4-glucanohydrolase); Region: AmyAc_arch_bac_AmyA; cd11313 983545008417 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 983545008418 active site 983545008419 catalytic site [active] 983545008420 Flagellar L-ring protein; Region: FlgH; cl00905 983545008421 SMI1 / KNR4 family (SUKH-1); Region: SMI1_KNR4; cl01747 983545008422 SMI1 / KNR4 family (SUKH-1); Region: SMI1_KNR4; cl01747 983545008423 YqcI/YcgG family; Region: YqcI_YcgG; cl01349 983545008424 Domain of unknown function (DUF1989); Region: DUF1989; cl01474 983545008425 oxidoreductase; Provisional; Region: PRK06128 983545008426 classical (c) SDR, subgroup 1; Region: SDR_c1; cd05355 983545008427 NAD binding site [chemical binding]; other site 983545008428 metal binding site [ion binding]; metal-binding site 983545008429 active site 983545008430 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 983545008431 active site 983545008432 Protein of unknown function (DUF3423); Region: DUF3423; pfam11903 983545008433 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; cl14105 983545008434 Homocysteine S-methyltransferase; Region: S-methyl_trans; pfam02574 983545008435 Collagen triple helix repeat (20 copies); Region: Collagen; pfam01391 983545008436 Type IV pili methyl-accepting chemotaxis transducer N-term; Region: PilJ; pfam13675 983545008437 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 983545008438 dimer interface [polypeptide binding]; other site 983545008439 phosphorylation site [posttranslational modification] 983545008440 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 983545008441 ATP binding site [chemical binding]; other site 983545008442 Mg2+ binding site [ion binding]; other site 983545008443 G-X-G motif; other site 983545008444 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 983545008445 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 983545008446 active site 983545008447 phosphorylation site [posttranslational modification] 983545008448 intermolecular recognition site; other site 983545008449 dimerization interface [polypeptide binding]; other site 983545008450 Response regulator receiver domain; Region: Response_reg; pfam00072 983545008451 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 983545008452 active site 983545008453 phosphorylation site [posttranslational modification] 983545008454 intermolecular recognition site; other site 983545008455 dimerization interface [polypeptide binding]; other site 983545008456 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; cl01155 983545008457 Protein of unknown function (DUF1375); Region: DUF1375; cl11456 983545008458 Protein of unknown function (DUF3478); Region: DUF3478; pfam11964 983545008459 chromosome replication initiation inhibitor protein; Validated; Region: PRK03635 983545008460 Helix-turn-helix domains; Region: HTH; cl00088 983545008461 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 983545008462 dimerization interface [polypeptide binding]; other site 983545008463 LysE type translocator; Region: LysE; cl00565 983545008464 23S rRNA pseudouridylate synthase B; Provisional; Region: PRK10700 983545008465 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 983545008466 RNA binding surface [nucleotide binding]; other site 983545008467 PseudoU_synth_RluB: Pseudouridine synthase, Escherichia coli RluB like. This group is comprised of bacterial and eukaryotic proteins similar to E. coli RluB. Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to...; Region: PseudoU_synth_RluB; cd02556 983545008468 probable active site [active] 983545008469 Putative transcriptional regulators (Ypuh-like); Region: DUF387; cl00612 983545008470 ScpA/B protein; Region: ScpA_ScpB; cl00598 983545008471 Telomere recombination; Region: Sua5_yciO_yrdC; cl00305 983545008472 Predicted metal-dependent phosphoesterases (PHP family) [General function prediction only]; Region: COG0613 983545008473 anthranilate synthase component I; Provisional; Region: PRK13564 983545008474 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 983545008475 chorismate binding enzyme; Region: Chorismate_bind; cl10555 983545008476 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 983545008477 Glutamine amidotransferase class-I; Region: GATase; pfam00117 983545008478 glutamine binding [chemical binding]; other site 983545008479 catalytic triad [active] 983545008480 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 983545008481 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 983545008482 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 983545008483 bifunctional indole-3-glycerol phosphate synthase/phosphoribosylanthranilate isomerase; Provisional; Region: PRK09427 983545008484 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 983545008485 active site 983545008486 ribulose/triose binding site [chemical binding]; other site 983545008487 phosphate binding site [ion binding]; other site 983545008488 substrate (anthranilate) binding pocket [chemical binding]; other site 983545008489 product (indole) binding pocket [chemical binding]; other site 983545008490 Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are monomeric; Region: PRAI; cd00405 983545008491 active site 983545008492 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 983545008493 Pyridoxal-phosphate dependent enzyme; Region: PALP; pfam00291 983545008494 pyridoxal 5'-phosphate binding site [chemical binding]; other site 983545008495 catalytic residue [active] 983545008496 tryptophan synthase subunit alpha; Provisional; Region: trpA; PRK13111 983545008497 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 983545008498 substrate binding site [chemical binding]; other site 983545008499 active site 983545008500 catalytic residues [active] 983545008501 heterodimer interface [polypeptide binding]; other site 983545008502 YCII-related domain; Region: YCII; cl00999 983545008503 RF-1 domain; Region: RF-1; cl02875 983545008504 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 983545008505 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 983545008506 active site 983545008507 phosphorylation site [posttranslational modification] 983545008508 intermolecular recognition site; other site 983545008509 dimerization interface [polypeptide binding]; other site 983545008510 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 983545008511 DNA binding site [nucleotide binding] 983545008512 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080 983545008513 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 983545008514 ATP binding site [chemical binding]; other site 983545008515 Mg2+ binding site [ion binding]; other site 983545008516 G-X-G motif; other site 983545008517 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; cl01155 983545008518 Transcriptional regulator [Transcription]; Region: LysR; COG0583 983545008519 Helix-turn-helix domains; Region: HTH; cl00088 983545008520 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 983545008521 putative effector binding pocket; other site 983545008522 dimerization interface [polypeptide binding]; other site 983545008523 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 983545008524 Mechanosensitive ion channel; Region: MS_channel; pfam00924 983545008525 oxidoreductase alpha (molybdopterin) subunit; Region: Fdhalpha-like; TIGR01701 983545008526 The MopB_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. These members belong to the molybdopterin_binding (MopB) superfamily of proteins; Region: MopB_ydeP; cd02767 983545008527 putative molybdopterin cofactor binding site [chemical binding]; other site 983545008528 The MopB_CT_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. This CD is of the conserved molybdopterin_binding C-terminal (MopB_CT) region...; Region: MopB_CT_ydeP; cd02787 983545008529 putative molybdopterin cofactor binding site; other site 983545008530 FdhD/NarQ family; Region: FdhD-NarQ; cl00659 983545008531 Predicted permeases [General function prediction only]; Region: COG0730; cl00498 983545008532 Integral membrane protein (DUF2244); Region: DUF2244; cl02302 983545008533 Protein of unknown function (DUF2855); Region: DUF2855; pfam11017 983545008534 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 983545008535 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 983545008536 Uncharacterized protein conserved in bacteria (DUF2059); Region: DUF2059; cl01243 983545008537 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 983545008538 N-terminal plug; other site 983545008539 ligand-binding site [chemical binding]; other site 983545008540 DNA topoisomerase IB, C-terminal catalytic domain. Topoisomerase I promotes the relaxation of both positive and negative DNA superhelical tension by introducing a transient single-stranded break in duplex DNA. This function is vital for the processes of...; Region: Topo_IB_C; cd00659 983545008541 DNA binding site [nucleotide binding] 983545008542 active site 983545008543 Int/Topo IB signature motif; other site 983545008544 catalytic residues [active] 983545008545 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 983545008546 Helix-turn-helix domains; Region: HTH; cl00088 983545008547 Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR9; cd08274 983545008548 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 983545008549 putative NAD(P) binding site [chemical binding]; other site 983545008550 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 983545008551 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 983545008552 Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389 983545008553 Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389 983545008554 Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389 983545008555 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 983545008556 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 983545008557 DNA-binding site [nucleotide binding]; DNA binding site 983545008558 UTRA domain; Region: UTRA; cl01230 983545008559 cysteine/glutathione ABC transporter membrane/ATP-binding component; Reviewed; Region: PRK11160 983545008560 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 983545008561 Walker A/P-loop; other site 983545008562 ATP binding site [chemical binding]; other site 983545008563 Q-loop/lid; other site 983545008564 ABC transporter signature motif; other site 983545008565 Walker B; other site 983545008566 D-loop; other site 983545008567 H-loop/switch region; other site 983545008568 thiol reductant ABC exporter, CydD subunit; Region: CydD; TIGR02857 983545008569 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 983545008570 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 983545008571 Walker A/P-loop; other site 983545008572 ATP binding site [chemical binding]; other site 983545008573 Q-loop/lid; other site 983545008574 ABC transporter signature motif; other site 983545008575 Walker B; other site 983545008576 D-loop; other site 983545008577 H-loop/switch region; other site 983545008578 Membrane bound YbgT-like protein; Region: YbgT_YccB; cl02039 983545008579 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 983545008580 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 983545008581 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; cl00562 983545008582 cytochrome d terminal oxidase subunit 1; Provisional; Region: PRK15097 983545008583 LysE type translocator; Region: LysE; cl00565 983545008584 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 983545008585 active site 983545008586 metal binding site [ion binding]; metal-binding site 983545008587 Acetyltransferase (GNAT) domain; Region: Acetyltransf_8; pfam13523 983545008588 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 983545008589 Cytochrome c554 and c-prime; Region: Cytochrome_C554; pfam13435 983545008590 Cytochrome c554 and c-prime; Region: Cytochrome_C554; pfam13435 983545008591 Cytochrome c554 and c-prime; Region: Cytochrome_C554; pfam13435 983545008592 Doubled CXXCH motif (Paired_CXXCH_1); Region: Paired_CXXCH_1; cl09905 983545008593 HEAT repeats; Region: HEAT_2; pfam13646 983545008594 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 983545008595 TPR motif; other site 983545008596 TPR repeat; Region: TPR_11; pfam13414 983545008597 binding surface 983545008598 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 983545008599 binding surface 983545008600 TPR motif; other site 983545008601 Tetratricopeptide repeat; Region: TPR_16; pfam13432 983545008602 Cupin domain; Region: Cupin_2; cl09118 983545008603 fumarylacetoacetase; Region: fum_ac_acetase; TIGR01266 983545008604 Domain of unknown function (DUF1969); Region: DUF1969; pfam09298 983545008605 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 983545008606 GST_N family, Class Zeta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens; Region: GST_N_Zeta; cd03042 983545008607 maleylacetoacetate isomerase; Region: maiA; TIGR01262 983545008608 C-terminal domain interface [polypeptide binding]; other site 983545008609 GSH binding site (G-site) [chemical binding]; other site 983545008610 putative dimer interface [polypeptide binding]; other site 983545008611 C-terminal, alpha helical domain of Class Zeta Glutathione S-transferases; Region: GST_C_Zeta; cd03191 983545008612 dimer interface [polypeptide binding]; other site 983545008613 N-terminal domain interface [polypeptide binding]; other site 983545008614 maleylacetoacetate (MAA) substrate binding site (H site) [chemical binding]; other site 983545008615 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 983545008616 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 983545008617 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 983545008618 Bestrophin, RFP-TM, chloride channel; Region: Bestrophin; cl01544 983545008619 C4-dicarboxylate anaerobic carrier; Region: DcuC; cl15356 983545008620 Cupin domain; Region: Cupin_2; cl09118 983545008621 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 983545008622 Helix-turn-helix domains; Region: HTH; cl00088 983545008623 Cupin domain; Region: Cupin_2; cl09118 983545008624 Transcriptional regulator [Transcription]; Region: LysR; COG0583 983545008625 Helix-turn-helix domains; Region: HTH; cl00088 983545008626 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 983545008627 putative effector binding pocket; other site 983545008628 dimerization interface [polypeptide binding]; other site 983545008629 Beta-galactosidase; Region: Glyco_hydro_42; cl03154 983545008630 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; cl08371 983545008631 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 983545008632 Cellulase (glycosyl hydrolase family 5); Region: Cellulase; cl15381 983545008633 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383 983545008634 Glutamate-cysteine ligase; Region: Glu_cys_ligase; cl15791 983545008635 Predicted esterase [General function prediction only]; Region: COG0627 983545008636 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 983545008637 class III alcohol dehydrogenases; Region: alcohol_DH_class_III; cd08300 983545008638 S-(hydroxymethyl)glutathione dehydrogenase/class III alcohol dehydrogenase; Region: adh_III_F_hyde; TIGR02818 983545008639 substrate binding site [chemical binding]; other site 983545008640 catalytic Zn binding site [ion binding]; other site 983545008641 NAD binding site [chemical binding]; other site 983545008642 structural Zn binding site [ion binding]; other site 983545008643 dimer interface [polypeptide binding]; other site 983545008644 Small Multidrug Resistance protein; Region: Multi_Drug_Res; cl00910 983545008645 LysR family transcriptional regulator; Provisional; Region: PRK14997 983545008646 Helix-turn-helix domains; Region: HTH; cl00088 983545008647 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like_1; cd08470 983545008648 putative effector binding pocket; other site 983545008649 putative dimerization interface [polypeptide binding]; other site 983545008650 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 983545008651 active site 983545008652 metal binding site [ion binding]; metal-binding site 983545008653 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 983545008654 Glutamate synthase domain 2 [Amino acid transport and metabolism]; Region: GltB; COG0069 983545008655 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 983545008656 active site 983545008657 FMN binding site [chemical binding]; other site 983545008658 substrate binding site [chemical binding]; other site 983545008659 3Fe-4S cluster binding site [ion binding]; other site 983545008660 Uncharacterized conserved protein [Function unknown]; Region: COG2966 983545008661 Protein of unknown function (DUF1212); Region: DUF1212; cl01118 983545008662 Protein of unknown function (DUF1212); Region: DUF1212; cl01118 983545008663 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 983545008664 classical (c) SDRs; Region: SDR_c; cd05233 983545008665 NAD(P) binding site [chemical binding]; other site 983545008666 active site 983545008667 Cytochrome c; Region: Cytochrom_C; cl11414 983545008668 Streptogramin lyase [Defense mechanisms]; Region: Vgb; COG4257 983545008669 Protein of unknown function (DUF3466); Region: DUF3466; pfam11949 983545008670 Ethanolamine ammonia-lyase light chain (EutC); Region: EutC; cl01762 983545008671 ethanolamine ammonia lyase large subunit; Provisional; Region: PRK15067 983545008672 Ethanolamine ammonia lyase large subunit (EutB); Region: EutB; pfam06751 983545008673 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 983545008674 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD1; cd05283 983545008675 putative NAD(P) binding site [chemical binding]; other site 983545008676 putative substrate binding site [chemical binding]; other site 983545008677 catalytic Zn binding site [ion binding]; other site 983545008678 structural Zn binding site [ion binding]; other site 983545008679 dimer interface [polypeptide binding]; other site 983545008680 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933 983545008681 FMN binding site [chemical binding]; other site 983545008682 active site 983545008683 substrate binding site [chemical binding]; other site 983545008684 catalytic residue [active] 983545008685 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 983545008686 metal binding site [ion binding]; metal-binding site 983545008687 active site 983545008688 I-site; other site 983545008689 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 983545008690 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 983545008691 putative substrate translocation pore; other site 983545008692 probable AcnD-accessory protein PrpF; Region: prpF; TIGR02334 983545008693 PrpF protein; Region: PrpF; pfam04303 983545008694 2-methylisocitrate dehydratase, Fe/S-dependent; Region: 2met_isocit_dHY; TIGR02333 983545008695 Aconitase A catalytic domain; Region: AcnA_IRP; cd01586 983545008696 substrate binding site [chemical binding]; other site 983545008697 ligand binding site [chemical binding]; other site 983545008698 Aconitase swivel domain. Aconitase (aconitate hydratase) catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle. This is the aconitase swivel domain, which undergoes swivelling conformational change in the enzyme...; Region: Aconitase_swivel; cl00215 983545008699 substrate binding site [chemical binding]; other site 983545008700 Escherichia coli (Ec) 2-methylcitrate synthase (2MCS)_like. 2MCS catalyzes the condensation of propionyl-coenzyme A (PrCoA) and oxalacetate (OAA) to form 2-methylcitrate and coenzyme A (CoA) during propionate metabolism. Citrate synthase (CS) catalyzes...; Region: Ec2MCS_like; cd06108 983545008701 dimer interface [polypeptide binding]; other site 983545008702 Citrate synthase; Region: Citrate_synt; pfam00285 983545008703 active site 983545008704 citrylCoA binding site [chemical binding]; other site 983545008705 oxalacetate/citrate binding site [chemical binding]; other site 983545008706 coenzyme A binding site [chemical binding]; other site 983545008707 catalytic triad [active] 983545008708 PEP phosphonomutase and related enzymes [Carbohydrate transport and metabolism]; Region: PrpB; COG2513 983545008709 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 983545008710 tetramer interface [polypeptide binding]; other site 983545008711 active site 983545008712 Mg2+/Mn2+ binding site [ion binding]; other site 983545008713 Transcriptional regulators [Transcription]; Region: GntR; COG1802 983545008714 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 983545008715 DNA-binding site [nucleotide binding]; DNA binding site 983545008716 FCD domain; Region: FCD; cl11656 983545008717 RelA- and SpoT-like ppGpp Synthetases and Hydrolases, catalytic domain; Region: Rel-Spo_like; cl11966 983545008718 putative S-transferase; Provisional; Region: PRK11752 983545008719 Predicted transcriptional regulator [Transcription]; Region: COG2944 983545008720 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 983545008721 Sulfatase; Region: Sulfatase; cl10460 983545008722 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 983545008723 Sulfatase; Region: Sulfatase; cl10460 983545008724 TonB-dependent receptor; Region: TonB-Xanth-Caul; TIGR01782 983545008725 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl00284 983545008726 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 983545008727 ligand-binding site [chemical binding]; other site 983545008728 acyl-CoA dehydrogenase; Provisional; Region: PTZ00456 983545008729 Acyl-CoA dehydrogenase N terminal; Region: AcylCoA_DH_N; pfam12418 983545008730 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 983545008731 active site 983545008732 Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806 983545008733 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 983545008734 gluconate 5-dehydrogenase; Provisional; Region: PRK08213 983545008735 NAD(P) binding site [chemical binding]; other site 983545008736 active site 983545008737 Uncharacterized protein family (UPF0075); Region: UPF0075; cl04217 983545008738 vitamin B12/cobalamin outer membrane transporter; Provisional; Region: btuB; PRK10641 983545008739 TonB-dependent Receptor Plug Domain; Region: Plug; cl08461 983545008740 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl00284 983545008741 Protein of unknown function, DUF599; Region: DUF599; cl01575 983545008742 Small Multidrug Resistance protein; Region: Multi_Drug_Res; cl00910 983545008743 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 983545008744 Glyoxalase I catalyzes the isomerization of the hemithioacetal, formed by a 2-oxoaldehyde and glutathione, to S-D-lactoylglutathione; Region: Glyoxalase_I; cd07233 983545008745 dimer interface [polypeptide binding]; other site 983545008746 active site 983545008747 metal binding site [ion binding]; metal-binding site 983545008748 glutathione binding site [chemical binding]; other site 983545008749 glycerophosphodiester phosphodiesterase; Provisional; Region: glpQ; PRK11143 983545008750 Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615 983545008751 active site 983545008752 catalytic site [active] 983545008753 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 983545008754 ligand binding site [chemical binding]; other site 983545008755 DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012 983545008756 active site 983545008757 catalytic site [active] 983545008758 substrate binding site [chemical binding]; other site 983545008759 peroxidase; Provisional; Region: PRK15000 983545008760 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 983545008761 dimer interface [polypeptide binding]; other site 983545008762 decamer (pentamer of dimers) interface [polypeptide binding]; other site 983545008763 catalytic triad [active] 983545008764 peroxidatic and resolving cysteines [active] 983545008765 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; cl01093 983545008766 Glutaredoxin (GRX) family, PKC-interacting cousin of TRX (PICOT)-like subfamily; composed of PICOT and GRX-PICOT-like proteins. The non-PICOT members of this family contain only the GRX-like domain, whereas PICOT contains an N-terminal TRX-like domain...; Region: GRX_PICOT_like; cd03028 983545008767 putative GSH binding site [chemical binding]; other site 983545008768 catalytic residues [active] 983545008769 superoxide dismutase; Provisional; Region: PRK10543 983545008770 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 983545008771 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 983545008772 PrkA family serine protein kinase; Provisional; Region: PRK15455 983545008773 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 983545008774 PrkA serine protein kinase C-terminal domain; Region: PrkA; pfam06798 983545008775 Uncharacterized conserved protein [Function unknown]; Region: COG2718 983545008776 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 983545008777 SpoVR family protein; Provisional; Region: PRK11767 983545008778 Uncharacterized conserved protein [Function unknown]; Region: SpoVR; COG2719 983545008779 Uncharacterized conserved protein (DUF2132); Region: DUF2132; cl01894 983545008780 Protein of unknown function DUF45; Region: DUF45; cl00636 983545008781 Uncharacterized protein family (UPF0231); Region: UPF0231; cl11474 983545008782 Transcription factor zinc-finger; Region: zf-TFIIB; cl01565 983545008783 Transcription factor zinc-finger; Region: zf-TFIIB; cl01565 983545008784 Cupin domain; Region: Cupin_2; cl09118 983545008785 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 983545008786 Na+/H+ antiporter [Energy production and conversion]; Region: NhaC; COG1757 983545008787 C4-dicarboxylate anaerobic carrier; Region: DcuC; cl15356 983545008788 Alpha amylase catalytic domain found in bacterial cyclomaltodextrinases and related proteins; Region: AmyAc_bac_CMD_like_2; cd11339 983545008789 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 983545008790 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 983545008791 active site 983545008792 Alpha amylase catalytic domain found in bacterial cyclomaltodextrinases and related proteins; Region: AmyAc_bac_CMD_like_2; cd11339 983545008793 active site 983545008794 catalytic site [active] 983545008795 Domain of unknown function (DUF336); Region: DUF336; cl01249 983545008796 Predicted oxidoreductases (related to aryl-alcohol dehydrogenases) [Energy production and conversion]; Region: Tas; COG0667 983545008797 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 983545008798 active site 983545008799 catalytic tetrad [active] 983545008800 Transcriptional regulator [Transcription]; Region: LysR; COG0583 983545008801 Helix-turn-helix domains; Region: HTH; cl00088 983545008802 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 983545008803 putative effector binding pocket; other site 983545008804 dimerization interface [polypeptide binding]; other site 983545008805 mycofactocin system FadH/OYE family oxidoreductase 2; Region: mycofact_OYE_2; TIGR03997 983545008806 2,4-dienoyl-CoA reductase (DCR) FMN-binding domain. DCR in E. coli is an iron-sulfur flavoenzyme which contains FMN, FAD, and a 4Fe-4S cluster. It is also a monomer, unlike that of its eukaryotic counterparts which form homotetramers and lack the...; Region: DCR_FMN; cd02930 983545008807 active site 983545008808 FMN binding site [chemical binding]; other site 983545008809 2,4-decadienoyl-CoA binding site; other site 983545008810 catalytic residue [active] 983545008811 4Fe-4S cluster binding site [ion binding]; other site 983545008812 enoyl-CoA hydratase; Provisional; Region: PRK06142 983545008813 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 983545008814 substrate binding site [chemical binding]; other site 983545008815 oxyanion hole (OAH) forming residues; other site 983545008816 trimer interface [polypeptide binding]; other site 983545008817 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 983545008818 Helix-turn-helix domains; Region: HTH; cl00088 983545008819 WHG domain; Region: WHG; pfam13305 983545008820 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK08276 983545008821 AMP-binding enzyme; Region: AMP-binding; cl15778 983545008822 Protein of unknown function (DUF419); Region: DUF419; cl15265 983545008823 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic 'goose-type' lysozymes (GEWL). LTs catalyze...; Region: LT_GEWL; cd00254 983545008824 N-acetyl-D-glucosamine binding site [chemical binding]; other site 983545008825 catalytic residue [active] 983545008826 Glutamate-cysteine ligase; Region: Glu_cys_ligase; cl15791 983545008827 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 983545008828 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 983545008829 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 983545008830 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 983545008831 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 983545008832 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 983545008833 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cl00086 983545008834 PseudoU_synth_RsuA/RluD: Pseudouridine synthase, RsuA/RluD family. This group is comprised of eukaryotic, bacterial and archeal proteins similar to eight site specific Escherichia coli pseudouridine synthases: RsuA, RluA, RluB, RluC, RluD, RluE, RluF and...; Region: PseudoU_synth_RluCD_like; cd02869 983545008835 active site 983545008836 2-dehydropantoate 2-reductase; Reviewed; Region: PRK06522 983545008837 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 983545008838 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 983545008839 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 983545008840 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 983545008841 dimer interface [polypeptide binding]; other site 983545008842 putative anticodon binding site; other site 983545008843 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 983545008844 motif 1; other site 983545008845 active site 983545008846 motif 2; other site 983545008847 motif 3; other site 983545008848 peptide chain release factor 2; Validated; Region: prfB; PRK00578 983545008849 RF-1 domain; Region: RF-1; cl02875 983545008850 RF-1 domain; Region: RF-1; cl02875 983545008851 Arginyl tRNA synthetase N terminal domain; Region: Arg_tRNA_synt_N; cl04104 983545008852 arginine-tRNA ligase; Region: PLN02286 983545008853 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 983545008854 active site 983545008855 HIGH motif; other site 983545008856 KMSK motif region; other site 983545008857 Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956 983545008858 tRNA binding surface [nucleotide binding]; other site 983545008859 anticodon binding site; other site 983545008860 peptide chain release factor 3; Provisional; Region: prfC; PRK00741 983545008861 Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169 983545008862 G1 box; other site 983545008863 putative GEF interaction site [polypeptide binding]; other site 983545008864 GTP/Mg2+ binding site [chemical binding]; other site 983545008865 Switch I region; other site 983545008866 G2 box; other site 983545008867 G3 box; other site 983545008868 Switch II region; other site 983545008869 G4 box; other site 983545008870 G5 box; other site 983545008871 RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689 983545008872 Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR6; cd08272 983545008873 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 983545008874 putative NAD(P) binding site [chemical binding]; other site 983545008875 Transcriptional regulator [Transcription]; Region: LysR; COG0583 983545008876 Helix-turn-helix domains; Region: HTH; cl00088 983545008877 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 983545008878 putative effector binding pocket; other site 983545008879 dimerization interface [polypeptide binding]; other site 983545008880 Protein of unknown function (DUF465); Region: DUF465; cl01070 983545008881 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 983545008882 NAD(P) binding site [chemical binding]; other site 983545008883 active site 983545008884 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 983545008885 non-specific DNA binding site [nucleotide binding]; other site 983545008886 salt bridge; other site 983545008887 sequence-specific DNA binding site [nucleotide binding]; other site 983545008888 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 983545008889 non-specific DNA binding site [nucleotide binding]; other site 983545008890 salt bridge; other site 983545008891 sequence-specific DNA binding site [nucleotide binding]; other site 983545008892 ribosomal-protein-alanine N-acetyltransferase; Provisional; Region: rimI; PRK09491 983545008893 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 983545008894 Coenzyme A binding pocket [chemical binding]; other site 983545008895 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: APH_ChoK_like; cd05120 983545008896 active site 983545008897 substrate binding site [chemical binding]; other site 983545008898 ATP binding site [chemical binding]; other site 983545008899 Nicotinamide mononucleotide transporter; Region: NMN_transporter; cl01256 983545008900 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 983545008901 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 983545008902 N-terminal plug; other site 983545008903 ligand-binding site [chemical binding]; other site 983545008904 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 983545008905 Domain of unknown function (DUF1726); Region: DUF1726; pfam08351 983545008906 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 983545008907 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 983545008908 Possible tRNA binding domain; Region: tRNA_bind_2; pfam13725 983545008909 Peptidase inhibitor I9; Region: Inhibitor_I9; pfam05922 983545008910 Peptidase S8 family domain, uncharacterized subfamily 3; Region: Peptidases_S8_3; cd04852 983545008911 active site 983545008912 catalytic triad [active] 983545008913 PA: Protease-associated (PA) domain. The PA domain is an insert domain in a diverse fraction of proteases. The significance of the PA domain to many of the proteins in which it is inserted is undetermined. It may be a protein-protein interaction domain; Region: PA; cl08238 983545008914 PA/protease or protease-like domain interface [polypeptide binding]; other site 983545008915 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 983545008916 catalytic residues [active] 983545008917 Fn3-like domain (DUF1034); Region: DUF1034; pfam06280 983545008918 PEP-CTERM motif; Region: VPEP; cl15443 983545008919 Phosphatidylserine synthase [Lipid metabolism]; Region: PssA; COG1183 983545008920 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 983545008921 putative PEP-CTERM system TPR-repeat lipoprotein; Region: PEP_TPR_lipo; TIGR02917 983545008922 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 983545008923 binding surface 983545008924 TPR motif; other site 983545008925 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 983545008926 binding surface 983545008927 TPR motif; other site 983545008928 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 983545008929 binding surface 983545008930 TPR motif; other site 983545008931 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 983545008932 Clp amino terminal domain; Region: Clp_N; pfam02861 983545008933 Clp amino terminal domain; Region: Clp_N; pfam02861 983545008934 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 983545008935 Walker A motif; other site 983545008936 ATP binding site [chemical binding]; other site 983545008937 Walker B motif; other site 983545008938 arginine finger; other site 983545008939 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 983545008940 Walker A motif; other site 983545008941 ATP binding site [chemical binding]; other site 983545008942 Walker B motif; other site 983545008943 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; cl11083 983545008944 Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; cl00650 983545008945 Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496 983545008946 23S rRNA pseudouridine synthase D; Provisional; Region: rluD; PRK11180 983545008947 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 983545008948 RNA binding surface [nucleotide binding]; other site 983545008949 PseudoU_synth_RsuA/RluD: Pseudouridine synthase, RsuA/RluD family. This group is comprised of eukaryotic, bacterial and archeal proteins similar to eight site specific Escherichia coli pseudouridine synthases: RsuA, RluA, RluB, RluC, RluD, RluE, RluF and...; Region: PseudoU_synth_RluCD_like; cd02869 983545008950 active site 983545008951 outer membrane assembly lipoprotein YfiO; Region: OM_YfiO; TIGR03302 983545008952 anti-sigma factor, putative, ChrR family; Region: anti_sig_ChrR; TIGR02451 983545008953 Cupin domain; Region: Cupin_2; cl09118 983545008954 RNA polymerase sigma factor; Provisional; Region: PRK11924 983545008955 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 983545008956 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 983545008957 DNA binding residues [nucleotide binding] 983545008958 Uncharacterized protein, similar to the N-terminal domain of Lon protease [General function prediction only]; Region: COG2802 983545008959 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 983545008960 short chain dehydrogenase; Provisional; Region: PRK06101 983545008961 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 983545008962 NAD(P) binding site [chemical binding]; other site 983545008963 active site 983545008964 Predicted NAD/FAD-binding protein [General function prediction only]; Region: COG2907 983545008965 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 983545008966 Uncharacterized conserved protein [Function unknown]; Region: COG3496 983545008967 Protein of unknown function (DUF1365); Region: DUF1365; pfam07103 983545008968 Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane]; Region: Cfa; COG2230 983545008969 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 983545008970 S-adenosylmethionine binding site [chemical binding]; other site 983545008971 Protein of unknown function (DUF3833); Region: DUF3833; pfam12915 983545008972 flagellar motor protein MotB; Reviewed; Region: motB; PRK08944 983545008973 Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677 983545008974 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 983545008975 ligand binding site [chemical binding]; other site 983545008976 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 983545008977 Flagellar motor component [Cell motility and secretion]; Region: MotA; COG1291 983545008978 Exonuclease VII small subunit; Region: Exonuc_VII_S; cl00750 983545008979 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 983545008980 substrate binding pocket [chemical binding]; other site 983545008981 chain length determination region; other site 983545008982 substrate-Mg2+ binding site; other site 983545008983 catalytic residues [active] 983545008984 aspartate-rich region 1; other site 983545008985 active site lid residues [active] 983545008986 aspartate-rich region 2; other site 983545008987 1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444 983545008988 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 983545008989 TPP-binding site; other site 983545008990 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 983545008991 PYR/PP interface [polypeptide binding]; other site 983545008992 dimer interface [polypeptide binding]; other site 983545008993 TPP binding site [chemical binding]; other site 983545008994 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 983545008995 Uncharacterized BCR, YaiI/YqxD family COG1671; Region: DUF188; cl00727 983545008996 Phosphatidylglycerophosphatase A; a bacterial membrane-associated enzyme involved in lipid metabolism; Region: PgpA; cd06971 983545008997 tetramer interfaces [polypeptide binding]; other site 983545008998 binuclear metal-binding site [ion binding]; other site 983545008999 thiamine monophosphate kinase; Provisional; Region: PRK05731 983545009000 ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194 983545009001 ATP binding site [chemical binding]; other site 983545009002 dimerization interface [polypeptide binding]; other site 983545009003 Transcription termination factor NusB (N protein-Utilization Substance B). NusB plays a key role in the regulation of ribosomal RNA biosynthesis in eubacteria by modulating the efficiency of transcriptional antitermination. NusB along with other Nus...; Region: Terminator_NusB; cd00619 983545009004 putative RNA binding site [nucleotide binding]; other site 983545009005 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 983545009006 homopentamer interface [polypeptide binding]; other site 983545009007 active site 983545009008 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II-like protein; Provisional; Region: PRK14019 983545009009 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; cl00336 983545009010 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cl00522 983545009011 dimerization interface [polypeptide binding]; other site 983545009012 active site 983545009013 riboflavin synthase subunit alpha; Provisional; Region: PRK09289 983545009014 Lumazine binding domain; Region: Lum_binding; pfam00677 983545009015 Lumazine binding domain; Region: Lum_binding; pfam00677 983545009016 bifunctional diaminohydroxyphosphoribosylaminopyrimidine deaminase/5-amino-6-(5-phosphoribosylamino)uracil reductase; Provisional; Region: ribD; PRK10786 983545009017 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 983545009018 catalytic motif [active] 983545009019 Zn binding site [ion binding]; other site 983545009020 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cl00161 983545009021 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 983545009022 ATP cone domain; Region: ATP-cone; pfam03477 983545009023 Sporulation related domain; Region: SPOR; cl10051 983545009024 P pilus assembly protein, porin PapC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimD; COG3188 983545009025 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383 983545009026 Sporulation related domain; Region: SPOR; cl10051 983545009027 P pilus assembly protein, chaperone PapD [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimC; COG3121 983545009028 TolB amino-terminal domain; Region: TolB_N; cl00639 983545009029 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 983545009030 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 983545009031 dimer interface [polypeptide binding]; other site 983545009032 glycine-pyridoxal phosphate binding site [chemical binding]; other site 983545009033 active site 983545009034 folate binding site [chemical binding]; other site 983545009035 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 983545009036 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 983545009037 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; cl11611 983545009038 Acetylornithine deacetylase/Succinyl-diaminopimelate desuccinylase and related deacylases [Amino acid transport and metabolism]; Region: ArgE; COG0624 983545009039 M20 Peptidase Glutamate carboxypeptidase, a periplasmic enzyme; Region: M20_CPDG2; cd03885 983545009040 metal binding site [ion binding]; metal-binding site 983545009041 dimer interface [polypeptide binding]; other site 983545009042 putative ABC transporter ATP-binding protein; Reviewed; Region: PRK11819 983545009043 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 983545009044 Walker A/P-loop; other site 983545009045 ATP binding site [chemical binding]; other site 983545009046 Q-loop/lid; other site 983545009047 ABC transporter signature motif; other site 983545009048 Walker B; other site 983545009049 D-loop; other site 983545009050 H-loop/switch region; other site 983545009051 ABC transporter; Region: ABC_tran_2; pfam12848 983545009052 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 983545009053 PAS domain; Region: PAS_9; pfam13426 983545009054 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 983545009055 GAF domain; Region: GAF; cl15785 983545009056 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 983545009057 heme pocket [chemical binding]; other site 983545009058 putative active site [active] 983545009059 GAF domain; Region: GAF_2; pfam13185 983545009060 GAF domain; Region: GAF; cl15785 983545009061 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 983545009062 PAS domain; Region: PAS_9; pfam13426 983545009063 putative active site [active] 983545009064 heme pocket [chemical binding]; other site 983545009065 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 983545009066 dimer interface [polypeptide binding]; other site 983545009067 phosphorylation site [posttranslational modification] 983545009068 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 983545009069 ATP binding site [chemical binding]; other site 983545009070 Mg2+ binding site [ion binding]; other site 983545009071 G-X-G motif; other site 983545009072 Response regulator receiver domain; Region: Response_reg; pfam00072 983545009073 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 983545009074 active site 983545009075 phosphorylation site [posttranslational modification] 983545009076 intermolecular recognition site; other site 983545009077 dimerization interface [polypeptide binding]; other site 983545009078 UbiA prenyltransferase family; Region: UbiA; cl00337 983545009079 Prokaryotic Cytochrome C oxidase subunit IV; Region: COX4_pro; cl01204 983545009080 Ubiquinol oxidase subunit III subfamily. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously...; Region: Ubiquinol_oxidase_III; cd02863 983545009081 Subunit I/III interface [polypeptide binding]; other site 983545009082 Subunit III/IV interface [polypeptide binding]; other site 983545009083 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 983545009084 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 983545009085 D-pathway; other site 983545009086 Putative ubiquinol binding site [chemical binding]; other site 983545009087 Low-spin heme (heme b) binding site [chemical binding]; other site 983545009088 Putative water exit pathway; other site 983545009089 Binuclear center (heme o3/CuB) [ion binding]; other site 983545009090 K-pathway; other site 983545009091 Putative proton exit pathway; other site 983545009092 cytochrome o ubiquinol oxidase subunit II; Provisional; Region: PRK10525 983545009093 Protein of unknown function (DUF4079); Region: DUF4079; pfam13301 983545009094 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; cl11412 983545009095 COX Aromatic Rich Motif; Region: COX_ARM; pfam06481 983545009096 Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228 983545009097 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 983545009098 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 983545009099 active site 983545009100 M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like2; cd05667 983545009101 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 983545009102 metal binding site [ion binding]; metal-binding site 983545009103 putative dimer interface [polypeptide binding]; other site 983545009104 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 983545009105 Helix-turn-helix domains; Region: HTH; cl00088 983545009106 Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; COG1914 983545009107 Glutathione-dependent formaldehyde-activating enzyme; Region: GFA; cl01553 983545009108 aconitate hydratase; Validated; Region: PRK09277 983545009109 Aconitase A catalytic domain; Region: AcnA_IRP; cd01586 983545009110 substrate binding site [chemical binding]; other site 983545009111 Aconitase catalytic domain; Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: Aconitase; cl00285 983545009112 ligand binding site [chemical binding]; other site 983545009113 Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580 983545009114 substrate binding site [chemical binding]; other site 983545009115 Entericidin EcnA/B family; Region: Entericidin; cl02322 983545009116 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 983545009117 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 983545009118 metal binding site [ion binding]; metal-binding site 983545009119 active site 983545009120 I-site; other site 983545009121 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 983545009122 Domain of unknown function (DUF4154); Region: DUF4154; pfam13689 983545009123 Putative MetA-pathway of phenol degradation; Region: Phenol_MetA_deg; cl01768 983545009124 DNA repair protein RadA; Provisional; Region: PRK11823 983545009125 Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121 983545009126 Walker A motif/ATP binding site; other site 983545009127 ATP binding site [chemical binding]; other site 983545009128 Walker B motif; other site 983545009129 Subunit ChlI of Mg-chelatase; Region: ChlI; cl12214 983545009130 PilZ domain; Region: PilZ; cl01260 983545009131 PilZ domain; Region: PilZ; cl01260 983545009132 phosphoserine phosphatase; Provisional; Region: serB; PRK11133 983545009133 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 983545009134 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 983545009135 motif II; other site 983545009136 Escherichia coli YaeB and related proteins; Region: UPF0066; cd09281 983545009137 homodimer interaction site [polypeptide binding]; other site 983545009138 cofactor binding site; other site 983545009139 prolyl-tRNA synthetase; Provisional; Region: PRK09194 983545009140 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent formation of...; Region: ProRS_core_prok; cd00779 983545009141 dimer interface [polypeptide binding]; other site 983545009142 motif 1; other site 983545009143 active site 983545009144 motif 2; other site 983545009145 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334 983545009146 putative deacylase active site [active] 983545009147 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it attaches...; Region: class_II_aaRS-like_core; cl00268 983545009148 active site 983545009149 motif 3; other site 983545009150 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 983545009151 anticodon binding site; other site 983545009152 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 983545009153 Hypothetical patatin similar to Z1214 protein of Escherichia coli; Region: Pat_hypo_Ecoli_Z1214_like; cd07209 983545009154 nucleophile elbow; other site 983545009155 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4807 983545009156 Protein of unknown function (DUF1456); Region: DUF1456; pfam07308 983545009157 Protein of unknown function (DUF1456); Region: DUF1456; pfam07308 983545009158 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 983545009159 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cl15762 983545009160 oxyanion hole (OAH) forming residues; other site 983545009161 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl15772 983545009162 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 983545009163 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 983545009164 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 983545009165 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 983545009166 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl15357 983545009167 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 983545009168 metal binding site [ion binding]; metal-binding site 983545009169 active site 983545009170 I-site; other site 983545009171 Response regulator receiver domain; Region: Response_reg; pfam00072 983545009172 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 983545009173 active site 983545009174 phosphorylation site [posttranslational modification] 983545009175 intermolecular recognition site; other site 983545009176 dimerization interface [polypeptide binding]; other site 983545009177 poly-beta-1,6 N-acetyl-D-glucosamine export porin PgaA; Region: PGA_TPR_OMP; TIGR03939 983545009178 heptad repeat 1-heptad repeat 2 region (ectodomain) of the transmembrane subunit of various endogenous retroviruses (ERVs) and infectious retroviruses, including Ebola virus and human immunodeficiency virus type 1 (HIV-1); Region: Ebola_HIV-1-like_HR1-HR2; cl02885 983545009179 Transcriptional regulator [Transcription]; Region: LysR; COG0583 983545009180 Helix-turn-helix domains; Region: HTH; cl00088 983545009181 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 983545009182 dimerization interface [polypeptide binding]; other site 983545009183 Lipase (class 3). Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is 'interfacial activation,' the process of...; Region: Lipase_3; cd00519 983545009184 active site flap/lid [active] 983545009185 nucleophilic elbow; other site 983545009186 catalytic triad [active] 983545009187 tRNA(Ile)-lysidine synthetase; Provisional; Region: tilS; PRK10660 983545009188 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 983545009189 Ligand Binding Site [chemical binding]; other site 983545009190 TilS substrate binding domain; Region: TilS; pfam09179 983545009191 B3/4 domain; Region: B3_4; cl11458 983545009192 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl15772 983545009193 acetyl-CoA carboxylase carboxyltransferase alpha subunit; Provisional; Region: accA; CHL00198 983545009194 DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673 983545009195 Bacterial DNA polymerase III alpha subunit; Region: DNA_pol3_alpha; pfam07733 983545009196 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 983545009197 generic binding surface I; other site 983545009198 generic binding surface II; other site 983545009199 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 983545009200 RNA/DNA hybrid binding site [nucleotide binding]; other site 983545009201 active site 983545009202 lipid-A-disaccharide synthase; Reviewed; Region: lpxB; PRK00025 983545009203 ipid-A-disaccharide synthase; Provisional; Region: PRK14089 983545009204 UDP-N-acetylglucosamine acyltransferase; Provisional; Region: PRK05289 983545009205 UDP-N-acetylglucosamine O-acyltransferase (UDP-GlcNAc acyltransferase): Proteins in this family catalyze the transfer of (R)-3-hydroxymyristic acid from its acyl carrier protein thioester to UDP-GlcNAc. It is the first enzyme in the lipid A biosynthetic...; Region: LbH_UDP-GlcNAc_AT; cd03351 983545009206 active site 983545009207 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 983545009208 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Provisional; Region: lpxD; PRK00892 983545009209 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase, LpxD; Region: LpxD; pfam04613 983545009210 UDP-3-O-acyl-glucosamine N-acyltransferase (LpxD): The enzyme catalyzes the transfer of 3-hydroxymyristic acid or 3-hydroxy-arachidic acid, depending on the organism, from the acyl carrier protein (ACP) to UDP-3-O-acyl-glucosamine to produce UDP-2; Region: LbH_LpxD; cd03352 983545009211 trimer interface [polypeptide binding]; other site 983545009212 active site 983545009213 UDP-GlcNAc binding site [chemical binding]; other site 983545009214 lipid binding site [chemical binding]; lipid-binding site 983545009215 periplasmic chaperone; Provisional; Region: PRK10780 983545009216 Outer membrane protein (OmpH-like); Region: OmpH; smart00935 983545009217 outer membrane protein assembly factor YaeT; Provisional; Region: PRK11067 983545009218 Surface antigen variable number repeat; Region: Surf_Ag_VNR; cl10520 983545009219 Surface antigen variable number repeat; Region: Surf_Ag_VNR; cl10520 983545009220 Surface antigen variable number repeat; Region: Surf_Ag_VNR; cl10520 983545009221 Surface antigen variable number repeat; Region: Surf_Ag_VNR; cl10520 983545009222 Surface antigen; Region: Bac_surface_Ag; cl03097 983545009223 zinc metallopeptidase RseP; Provisional; Region: PRK10779 983545009224 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 983545009225 active site 983545009226 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 983545009227 protein binding site [polypeptide binding]; other site 983545009228 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 983545009229 protein binding site [polypeptide binding]; other site 983545009230 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 983545009231 putative substrate binding region [chemical binding]; other site 983545009232 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447 983545009233 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 983545009234 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 983545009235 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 983545009236 Cytidylyltransferase family; Region: CTP_transf_1; cl00347 983545009237 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475 983545009238 Putative undecaprenyl diphosphate synthase; Region: Prenyltransf; pfam01255 983545009239 catalytic residue [active] 983545009240 putative FPP diphosphate binding site; other site 983545009241 putative FPP binding hydrophobic cleft; other site 983545009242 dimer interface [polypeptide binding]; other site 983545009243 putative IPP diphosphate binding site; other site 983545009244 ribosome recycling factor; Reviewed; Region: frr; PRK00083 983545009245 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are 'recycled' and ready for another round of...; Region: RRF; cd00520 983545009246 hinge region; other site 983545009247 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 983545009248 putative nucleotide binding site [chemical binding]; other site 983545009249 uridine monophosphate binding site [chemical binding]; other site 983545009250 homohexameric interface [polypeptide binding]; other site 983545009251 elongation factor Ts; Provisional; Region: tsf; PRK09377 983545009252 Ubiquitin Associated domain. The UBA domain is a commonly occurring sequence motif in some members of the ubiquitination pathway, UV excision repair proteins, and certain protein kinases. Although its specific role is so far unknown, it has been...; Region: UBA; cl00153 983545009253 Elongation factor TS; Region: EF_TS; pfam00889 983545009254 Elongation factor TS; Region: EF_TS; pfam00889 983545009255 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 983545009256 rRNA interaction site [nucleotide binding]; other site 983545009257 S8 interaction site; other site 983545009258 putative laminin-1 binding site; other site 983545009259 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 983545009260 active site 983545009261 PII uridylyl-transferase; Provisional; Region: PRK05007 983545009262 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 983545009263 metal binding triad; other site 983545009264 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 983545009265 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 983545009266 ACT domain family, ACT_UUR-like_1, includes the first of two C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_UUR-like_1; cd04900 983545009267 C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_ACR-UUR-like_2; cd04899 983545009268 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 983545009269 Escherichia coli YbbF/LpxH and related proteins, metallophosphatase domain; Region: MPP_YbbF-LpxH; cd07398 983545009270 putative active site [active] 983545009271 putative metal binding site [ion binding]; other site 983545009272 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: Unknown ACT14924; Region: LPLAT_ACT14924-like; cd07986 983545009273 putative acyl-acceptor binding pocket; other site 983545009274 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 983545009275 YebG protein; Region: YebG; cl01217 983545009276 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 983545009277 catalytic loop [active] 983545009278 iron binding site [ion binding]; other site 983545009279 chaperone protein HscA; Provisional; Region: hscA; PRK05183 983545009280 co-chaperone HscB; Provisional; Region: hscB; PRK05014 983545009281 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cl02542 983545009282 HSCB C-terminal oligomerisation domain; Region: HSCB_C; pfam07743 983545009283 Iron-sulphur cluster biosynthesis; Region: Fe-S_biosyn; cl00400 983545009284 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 983545009285 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 983545009286 trimerization site [polypeptide binding]; other site 983545009287 active site 983545009288 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 983545009289 cysteine desulfurase DndA; Region: DNA_S_dndA; TIGR03235 983545009290 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 983545009291 catalytic residue [active] 983545009292 Helix-turn-helix domains; Region: HTH; cl00088 983545009293 Rrf2 family protein; Region: rrf2_super; TIGR00738 983545009294 serine O-acetyltransferase; Region: cysE; TIGR01172 983545009295 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 983545009296 trimer interface [polypeptide binding]; other site 983545009297 active site 983545009298 substrate binding site [chemical binding]; other site 983545009299 CoA binding site [chemical binding]; other site 983545009300 tRNA (cytidine/uridine-2'-O-)-methyltransferase TrmJ; Provisional; Region: PRK15114 983545009301 SpoU rRNA Methylase family; Region: SpoU_methylase; cl00362 983545009302 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_1; cd08352 983545009303 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 983545009304 putative metal binding site [ion binding]; other site 983545009305 IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639 983545009306 active site 983545009307 dimerization interface [polypeptide binding]; other site 983545009308 preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022 983545009309 SecD/SecF GG Motif; Region: Sec_GG; pfam07549 983545009310 Protein export membrane protein; Region: SecD_SecF; cl14618 983545009311 SecD export protein N-terminal TM region; Region: SecD-TM1; cl08136 983545009312 preprotein translocase subunit SecD; Reviewed; Region: secD; PRK05812 983545009313 SecD/SecF GG Motif; Region: Sec_GG; pfam07549 983545009314 Protein export membrane protein; Region: SecD_SecF; cl14618 983545009315 Preprotein translocase subunit; Region: YajC; cl00806 983545009316 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; cl00409 983545009317 tRNA-guanine transglycosylases, various specificities; Region: tgt_general; TIGR00449 983545009318 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147 983545009319 Queuosine biosynthesis protein; Region: Queuosine_synth; cl00523 983545009320 Uncharacterized protein conserved in bacteria (DUF2170); Region: DUF2170; cl01551 983545009321 PspA/IM30 family; Region: PspA_IM30; pfam04012 983545009322 Ion channel; Region: Ion_trans_2; cl11596 983545009323 Protein of unknown function (DUF2491); Region: DUF2491; pfam10679 983545009324 Predicted membrane protein [Function unknown]; Region: COG3766 983545009325 Domain of Unknown Function (DUF350); Region: DUF350; pfam03994 983545009326 Domain of Unknown Function (DUF350); Region: DUF350; pfam03994 983545009327 Protein of unknown function (DUF1190); Region: DUF1190; cl10031 983545009328 A circularly permuted ATPgrasp; Region: CP_ATPgrasp_1; cl00503 983545009329 Rhomboid family; Region: Rhomboid; cl11446 983545009330 Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cd00016 983545009331 Alkaline phosphatase homologues; Region: alkPPc; smart00098 983545009332 active site 983545009333 dimer interface [polypeptide binding]; other site 983545009334 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 983545009335 tetramer interface [polypeptide binding]; other site 983545009336 active site 983545009337 Mg2+/Mn2+ binding site [ion binding]; other site 983545009338 Holliday junction DNA helicase RuvA; Provisional; Region: ruvA; PRK13901 983545009339 Members of the ICL/PEPM_KPHMT enzyme superfamily catalyze the formation and cleavage of either P-C or C-C bonds. Typical members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate...; Region: ICL_KPHMT; cl00435 983545009340 Transcriptional regulator [Transcription]; Region: LysR; COG0583 983545009341 Helix-turn-helix domains; Region: HTH; cl00088 983545009342 The C-terminal substrate binding domain of LysR-type transcriptional regulators that involved in the catabolism of nitroaromatic/naphthalene compounds and that of related regulators; contains the type 2 periplasmic binding fold; Region: PBP2_Nitroaromatics_like; cd08417 983545009343 substrate binding pocket [chemical binding]; other site 983545009344 dimerization interface [polypeptide binding]; other site 983545009345 Malate synthase G (MSG), monomeric enzyme present in some bacteria. In general, malate synthase catalyzes the Claisen condensation of glyoxylate and acetyl-CoA to malyl-CoA , which hydrolyzes to malate and CoA. This reaction is part of the glyoxylate...; Region: malate_synt_G; cd00728 983545009346 active site 983545009347 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_HprK; cl00270 983545009348 active site 983545009349 metal-binding site [ion binding] 983545009350 nucleotide-binding site [chemical binding]; other site 983545009351 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149 983545009352 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 983545009353 UDP glucuronic acid epimerase, extended (e) SDRs; Region: UDP_GE_SDE_e; cd05253 983545009354 putative NAD(P) binding site [chemical binding]; other site 983545009355 active site 983545009356 putative substrate binding site [chemical binding]; other site 983545009357 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 983545009358 putative active site [active] 983545009359 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 983545009360 ExoU and VipD-like proteins; homologus to patatin, cPLA2, and iPLA2; Region: Pat_ExoU_VipD_like; cd07207 983545009361 active site 983545009362 nucleophile elbow; other site 983545009363 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 983545009364 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 983545009365 FAD binding domain; Region: FAD_binding_4; pfam01565 983545009366 putative PEP-CTERM system TPR-repeat lipoprotein; Region: PEP_TPR_lipo; TIGR02917 983545009367 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 983545009368 binding surface 983545009369 TPR motif; other site 983545009370 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 983545009371 TPR motif; other site 983545009372 binding surface 983545009373 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 983545009374 binding surface 983545009375 TPR motif; other site 983545009376 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 983545009377 binding surface 983545009378 TPR motif; other site 983545009379 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 983545009380 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 983545009381 active site 983545009382 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 983545009383 This family is most closely related to the GT1 family of glycosyltransferases. WabH in Klebsiella pneumoniae has been shown to transfer a GlcNAc residue from UDP-GlcNAc onto the acceptor GalUA residue in the cellular outer core; Region: GT1_WabH_like; cd03811 983545009384 putative ADP-binding pocket [chemical binding]; other site 983545009385 Putative catalytic domain of lipopolysaccharide biosynthesis protein WalW and its bacterial homologs; Region: CE4_WalW; cd10935 983545009386 putative active site [active] 983545009387 putative catalytic site [active] 983545009388 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 983545009389 exosortase A system-associated amidotransferase 1; Region: eps_aminotran_1; TIGR03108 983545009390 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 983545009391 active site 983545009392 dimer interface [polypeptide binding]; other site 983545009393 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 983545009394 Ligand Binding Site [chemical binding]; other site 983545009395 Molecular Tunnel; other site 983545009396 OpgC protein; Region: OpgC_C; cl00792 983545009397 sugar transferase, PEP-CTERM/EpsH1 system associated; Region: stp2; TIGR03088 983545009398 This family is most closely related to the GT1 family of glycosyltransferases. WbnK in Shigella dysenteriae has been shown to be involved in the type 7 O-antigen biosynthesis; Region: GT1_WbnK_like; cd03807 983545009399 putative ADP-binding pocket [chemical binding]; other site 983545009400 Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; cl09156 983545009401 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 983545009402 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 983545009403 active site 983545009404 Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; cl09156 983545009405 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 983545009406 MatE; Region: MatE; cl10513 983545009407 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 983545009408 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 983545009409 serine O-acetyltransferase; Region: cysE; TIGR01172 983545009410 Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647 983545009411 trimer interface [polypeptide binding]; other site 983545009412 active site 983545009413 substrate binding site [chemical binding]; other site 983545009414 CoA binding site [chemical binding]; other site 983545009415 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 983545009416 sugar transferase, PEP-CTERM/EpsH1 system associated; Region: stp1; TIGR03087 983545009417 O-Antigen ligase; Region: Wzy_C; cl04850 983545009418 Periplasmic copper-binding protein (NosD); Region: NosD; pfam05048 983545009419 Predicted membrane protein [Function unknown]; Region: COG4083; cl15694 983545009420 Transmembrane exosortase (Exosortase_EpsH); Region: Exosortase_EpsH; pfam09721 983545009421 Protein of unknown function (DUF3485); Region: DUF3485; cl11827 983545009422 polysaccharide deacetylase family protein, PEP-CTERM locus subfamily; Region: pepcterm_polyde; TIGR03006 983545009423 Putative catalytic domain of uncharacterized prokaryotic polysaccharide deacetylases similar to bacterial PuuE allantoinases and Helicobacter pylori peptidoglycan deacetylase (HpPgdA); Region: CE4_PuuE_HpPgdA_like_2; cd10941 983545009424 putative active site [active] 983545009425 putative catalytic site [active] 983545009426 sugar transferase, PEP-CTERM system associated; Region: EpsB_2; TIGR03013 983545009427 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 983545009428 Bacterial sugar transferase; Region: Bac_transf; cl00939 983545009429 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 983545009430 putative polysaccharide export protein, PEP-CTERM sytem-associated; Region: pepcterm_export; TIGR03027 983545009431 SLBB domain; Region: SLBB; pfam10531 983545009432 polysaccharide chain length determinant protein, PEP-CTERM locus subfamily; Region: pepcterm_ChnLen; TIGR03007 983545009433 Chain length determinant protein; Region: Wzz; cl15801 983545009434 Fibrinogen alpha/beta chain family; Region: Fib_alpha; pfam08702 983545009435 exopolysaccharide/PEPCTERM locus tyrosine autokinase; Region: pepcterm_TyrKin; TIGR03018 983545009436 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 983545009437 Uncharacterized protein conserved in bacteria (DUF2320); Region: DUF2320; cl12051 983545009438 glutathione-regulated potassium-efflux system protein KefC; Provisional; Region: PRK03562 983545009439 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 983545009440 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 983545009441 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 983545009442 active site 983545009443 Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123 983545009444 Histone deacetylase domain; Region: Hist_deacetyl; cl02986 983545009445 hypothetical protein; Provisional; Region: PRK11239 983545009446 Protein of unknown function, DUF480; Region: DUF480; cl01209 983545009447 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 983545009448 Helix-turn-helix domain; Region: HTH_18; pfam12833 983545009449 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 983545009450 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 983545009451 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 983545009452 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 983545009453 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 983545009454 Gluconate 2-dehydrogenase subunit 3; Region: Gluconate_2-dh3; pfam13618 983545009455 PAS fold; Region: PAS_4; pfam08448 983545009456 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 983545009457 putative active site [active] 983545009458 heme pocket [chemical binding]; other site 983545009459 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 983545009460 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 983545009461 D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK11790 983545009462 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 983545009463 C-terminal ACT (regulatory) domain of D-3-Phosphoglycerate Dehydrogenase (3PGDH) found in fungi and bacteria; Region: ACT_3PGDH; cd04901 983545009464 L-serine binding site [chemical binding]; other site 983545009465 ACT domain interface; other site 983545009466 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 983545009467 catalytic residues [active] 983545009468 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD includes...; Region: RuvC_resolvase; cl00243 983545009469 Uncharacterized ACR, COG1678; Region: DUF179; cl00731 983545009470 glutathione synthetase; Provisional; Region: PRK05246 983545009471 Prokaryotic glutathione synthetase, N-terminal domain; Region: GSH-S_N; pfam02951 983545009472 ATP-grasp domain; Region: ATP-grasp_4; cl03087 983545009473 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 983545009474 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 983545009475 active site 983545009476 phosphorylation site [posttranslational modification] 983545009477 intermolecular recognition site; other site 983545009478 dimerization interface [polypeptide binding]; other site 983545009479 LytTr DNA-binding domain; Region: LytTR; cl04498 983545009480 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 983545009481 Histidine kinase; Region: His_kinase; pfam06580 983545009482 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 983545009483 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 983545009484 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 983545009485 active site 983545009486 phosphorylation site [posttranslational modification] 983545009487 intermolecular recognition site; other site 983545009488 dimerization interface [polypeptide binding]; other site 983545009489 LytTr DNA-binding domain; Region: LytTR; cl04498 983545009490 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383 983545009491 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl00284 983545009492 Protein of unknown function (DUF3718); Region: DUF3718; pfam12514 983545009493 Stress responsive A/B Barrel Domain; Region: Dabb; cl15807 983545009494 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 983545009495 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 983545009496 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 983545009497 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 983545009498 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 983545009499 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 983545009500 Domain of unknown function (DUF305); Region: DUF305; cl15795 983545009501 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 983545009502 Prokaryotic diacylglycerol kinase; Region: DAGK_prokar; cl00526 983545009503 putative metal dependent hydrolase; Provisional; Region: PRK11598 983545009504 Domain of unknown function (DUF1705); Region: DUF1705; pfam08019 983545009505 Sulfatase; Region: Sulfatase; cl10460 983545009506 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 983545009507 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl15769 983545009508 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 983545009509 dolichyl-phosphate beta-D-mannosyltransferase; Region: PLN02726 983545009510 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 983545009511 Ligand binding site; other site 983545009512 Putative Catalytic site; other site 983545009513 DXD motif; other site 983545009514 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 983545009515 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 983545009516 active site 983545009517 phosphorylation site [posttranslational modification] 983545009518 intermolecular recognition site; other site 983545009519 dimerization interface [polypeptide binding]; other site 983545009520 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 983545009521 DNA binding site [nucleotide binding] 983545009522 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 983545009523 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 983545009524 dimer interface [polypeptide binding]; other site 983545009525 phosphorylation site [posttranslational modification] 983545009526 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 983545009527 ATP binding site [chemical binding]; other site 983545009528 Mg2+ binding site [ion binding]; other site 983545009529 G-X-G motif; other site 983545009530 Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182 983545009531 PepSY-associated TM helix; Region: PepSY_TM_2; cl15813 983545009532 PepSY-associated TM helix; Region: PepSY_TM_2; cl15813 983545009533 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 983545009534 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 983545009535 N-terminal plug; other site 983545009536 ligand-binding site [chemical binding]; other site 983545009537 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 983545009538 ABC transporters, involved in the uptake of siderophores, heme, and vitamin B12, are widely conserved in bacteria and archaea. Only very few species lack representatives of the siderophore family transporters. The E. coli BtuCD protein is an ABC...; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 983545009539 Walker A/P-loop; other site 983545009540 ATP binding site [chemical binding]; other site 983545009541 Q-loop/lid; other site 983545009542 ABC transporter signature motif; other site 983545009543 Walker B; other site 983545009544 D-loop; other site 983545009545 H-loop/switch region; other site 983545009546 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 983545009547 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 983545009548 ABC-ATPase subunit interface; other site 983545009549 dimer interface [polypeptide binding]; other site 983545009550 putative PBP binding regions; other site 983545009551 Phosphoribosyltransferase; Region: DBI_PRT; pfam02277 983545009552 Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (DMB-PRT), also called CobT; Region: DMB-PRT_CobT; cd02439 983545009553 active site pocket [active] 983545009554 putative dimer interface [polypeptide binding]; other site 983545009555 putative cataytic base [active] 983545009556 Cobalamin-5-phosphate synthase; Region: CobS; cl00415 983545009557 Adenosylcobinamide kinase / adenosylcobinamide phosphate guanyltransferase (CobU). CobU is bifunctional cobalbumin biosynthesis enzymes which display adenosylcobinamide kinase and adenosylcobinamide phosphate guanyltransferase activity. This enzyme is a...; Region: CobU; cd00544 983545009558 homotrimer interface [polypeptide binding]; other site 983545009559 Walker A motif; other site 983545009560 GTP binding site [chemical binding]; other site 983545009561 Walker B motif; other site 983545009562 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 983545009563 catalytic core [active] 983545009564 cobyric acid synthase; Provisional; Region: PRK00784 983545009565 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 983545009566 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 983545009567 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 983545009568 catalytic triad [active] 983545009569 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 983545009570 ATP:corrinoid adenosyltransferase [Coenzyme metabolism]; Region: BtuR; COG2109 983545009571 ATP:corrinoid adenosyltransferase BtuR/CobO/CobP. This family consists of the BtuR, CobO, CobP proteins all of which are Cob(I)alamin (vitamin B12) adenosyltransferase, which is involved in cobalamin (vitamin B12) biosynthesis. This enzyme is a homodimer; Region: CobA_CobO_BtuR; cd00561 983545009572 homodimer interface [polypeptide binding]; other site 983545009573 Walker A motif; other site 983545009574 ATP binding site [chemical binding]; other site 983545009575 hydroxycobalamin binding site [chemical binding]; other site 983545009576 Walker B motif; other site 983545009577 Cobalamin binding protein BtuF. These proteins have been shown to function as initial receptors in ABC transport of vitamin B12 (cobalamin) in eubacterial and some archaeal species. They belong to the TroA superfamily of helical backbone metal receptor...; Region: BtuF; cd01144 983545009578 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 983545009579 cobalamin binding residues [chemical binding]; other site 983545009580 putative BtuC binding residues; other site 983545009581 dimer interface [polypeptide binding]; other site 983545009582 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 983545009583 catalytic core [active] 983545009584 CobD/Cbib protein; Region: CobD_Cbib; cl00561 983545009585 L-threonine-O-3-phosphate decarboxylase; Region: L_thr_O3P_dcar; TIGR01140 983545009586 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 983545009587 pyridoxal 5'-phosphate binding site [chemical binding]; other site 983545009588 homodimer interface [polypeptide binding]; other site 983545009589 catalytic residue [active] 983545009590 Transcriptional regulator [Transcription]; Region: LysR; COG0583 983545009591 Helix-turn-helix domains; Region: HTH; cl00088 983545009592 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 983545009593 putative effector binding pocket; other site 983545009594 dimerization interface [polypeptide binding]; other site 983545009595 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 983545009596 GST_N family, unknown subfamily 4; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_4; cd03056 983545009597 putative C-terminal domain interface [polypeptide binding]; other site 983545009598 putative GSH binding site (G-site) [chemical binding]; other site 983545009599 putative dimer interface [polypeptide binding]; other site 983545009600 C-terminal, alpha helical domain of an unknown subfamily 7 of Glutathione S-transferases; Region: GST_C_7; cd03206 983545009601 putative N-terminal domain interface [polypeptide binding]; other site 983545009602 putative dimer interface [polypeptide binding]; other site 983545009603 putative substrate binding pocket (H-site) [chemical binding]; other site 983545009604 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 983545009605 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 983545009606 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 983545009607 FAD_NAD(P)H binding domain of flavohemoglobin. Flavohemoglobins have a globin domain containing a B-type heme fused with a ferredoxin reductase-like FAD/NAD-binding domain. Flavohemoglobins detoxify nitric oxide (NO) via an NO dioxygenase reaction. The...; Region: flavohem_like_fad_nad_binding; cd06184 983545009608 FAD binding pocket [chemical binding]; other site 983545009609 FAD binding motif [chemical binding]; other site 983545009610 phosphate binding motif [ion binding]; other site 983545009611 beta-alpha-beta structure motif; other site 983545009612 NAD binding pocket [chemical binding]; other site 983545009613 Heme binding pocket [chemical binding]; other site 983545009614 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 983545009615 catalytic loop [active] 983545009616 iron binding site [ion binding]; other site 983545009617 Protein of unknown function (DUF1348); Region: DUF1348; pfam07080 983545009618 Endo-beta-mannanase [Carbohydrate transport and metabolism]; Region: COG3934 983545009619 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 983545009620 Interdomain contacts; other site 983545009621 Cytokine receptor motif; other site 983545009622 AGE domain; N-acyl-D-glucosamine 2-epimerase domain; Responsible for intermediate epimerization during biosynthesis of N-acetylneuraminic acid. Catalytic mechanism is believed to be via nucleotide elimination and readdition and is ATP modulated. AGE is...; Region: AGE; cl00183 983545009623 dimerization interface [polypeptide binding]; other site 983545009624 N-acyl-D-glucosamine 2-epimerase [Carbohydrate transport and metabolism]; Region: COG2942 983545009625 putative active cleft [active] 983545009626 Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647 983545009627 active site 983545009628 Sodium:solute symporter family; Region: SSF; cl00456 983545009629 Transcriptional regulators [Transcription]; Region: PurR; COG1609 983545009630 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 983545009631 DNA binding site [nucleotide binding] 983545009632 domain linker motif; other site 983545009633 Ligand-binding domain of an uncharacterized transcription regulator from Actinobacillus succinogenes and its close homologs from other bacteria; Region: PBP1_LacI_like_6; cd06284 983545009634 dimerization interface [polypeptide binding]; other site 983545009635 ligand binding site [chemical binding]; other site 983545009636 AGE domain; N-acyl-D-glucosamine 2-epimerase domain; Responsible for intermediate epimerization during biosynthesis of N-acetylneuraminic acid. Catalytic mechanism is believed to be via nucleotide elimination and readdition and is ATP modulated. AGE is...; Region: AGE; cl00183 983545009637 N-acyl-D-glucosamine 2-epimerase [Carbohydrate transport and metabolism]; Region: COG2942 983545009638 dimerization interface [polypeptide binding]; other site 983545009639 putative active cleft [active] 983545009640 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 983545009641 Sulfatase; Region: Sulfatase; cl10460 983545009642 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 983545009643 nudix motif; other site 983545009644 TonB-dependent receptor; Region: TonB-Xanth-Caul; TIGR01782 983545009645 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl00284 983545009646 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl00284 983545009647 Carbohydrate Binding Module 6 (CBM6); appended to several carbohydrate binding enzymes, including several glycoside hydrolase (GH) family 26 mannanase domains; Region: CBM6_mannanase-like; cd04086 983545009648 Glycosyl hydrolase family 26; Region: Glyco_hydro_26; cl09200 983545009649 Outer membrane cobalamin receptor protein [Coenzyme metabolism]; Region: BtuB; COG4206 983545009650 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 983545009651 N-terminal plug; other site 983545009652 ligand-binding site [chemical binding]; other site 983545009653 Carbon starvation protein CstA; Region: CstA; pfam02554 983545009654 C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722 983545009655 Ankyrin repeats (many copies); Region: Ank_4; pfam13637 983545009656 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 983545009657 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 983545009658 Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753 983545009659 Clade 1 of the heme-binding enzyme catalase; Region: catalase_clade_1; cd08154 983545009660 tetramer interface [polypeptide binding]; other site 983545009661 heme binding pocket [chemical binding]; other site 983545009662 Sulfatase; Region: Sulfatase; cl10460 983545009663 Type I phosphodiesterase / nucleotide pyrophosphatase; Region: Phosphodiest; pfam01663 983545009664 coproporphyrinogen III oxidase; Provisional; Region: PRK09249 983545009665 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 983545009666 FeS/SAM binding site; other site 983545009667 HemN C-terminal domain; Region: HemN_C; pfam06969 983545009668 Zinc-dependent metalloprotease; MMP_like sub-family 2. A group of bacterial metalloproteinase domains similar to matrix metalloproteinases and astacin; Region: ZnMc_MMP_like_2; cd04276 983545009669 active site 983545009670 Carbohydrate Binding Module 6 (CBM6) and CBM35_like superfamily; Region: CBM6-CBM35-CBM36_like; cl14880 983545009671 OpgC protein; Region: OpgC_C; cl00792 983545009672 Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; cl09156 983545009673 Acyltransferase family; Region: Acyl_transf_3; pfam01757 983545009674 OpgC protein; Region: OpgC_C; cl00792 983545009675 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 983545009676 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 983545009677 active site 983545009678 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 983545009679 This family is most closely related to the GT1 family of glycosyltransferases. WabH in Klebsiella pneumoniae has been shown to transfer a GlcNAc residue from UDP-GlcNAc onto the acceptor GalUA residue in the cellular outer core; Region: GT1_WabH_like; cd03811 983545009680 putative ADP-binding pocket [chemical binding]; other site 983545009681 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 983545009682 This family is most closely related to the GT1 family of glycosyltransferases. WabH in Klebsiella pneumoniae has been shown to transfer a GlcNAc residue from UDP-GlcNAc onto the acceptor GalUA residue in the cellular outer core; Region: GT1_WabH_like; cd03811 983545009683 putative ADP-binding pocket [chemical binding]; other site 983545009684 The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533 983545009685 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 983545009686 UDP glucuronic acid epimerase, extended (e) SDRs; Region: UDP_GE_SDE_e; cd05253 983545009687 putative NAD(P) binding site [chemical binding]; other site 983545009688 active site 983545009689 putative substrate binding site [chemical binding]; other site 983545009690 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 983545009691 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 983545009692 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 983545009693 OpgC protein; Region: OpgC_C; cl00792 983545009694 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 983545009695 MatE; Region: MatE; cl10513 983545009696 Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; cl09156 983545009697 Transglutaminase-like superfamily; Region: Transglut_core; cl10469 983545009698 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 983545009699 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 983545009700 metal binding site [ion binding]; metal-binding site 983545009701 active site 983545009702 I-site; other site 983545009703 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 983545009704 Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307 983545009705 O-Antigen ligase; Region: Wzy_C; cl04850 983545009706 Capsular polysaccharide biosynthesis protein [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: CapC; COG4464 983545009707 exopolysaccharide transport protein family; Region: eps_transp_fam; TIGR01005 983545009708 Chain length determinant protein; Region: Wzz; cl15801 983545009709 Chain length determinant protein; Region: Wzz; cl15801 983545009710 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 983545009711 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 983545009712 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 983545009713 putative polysaccharide export protein, PEP-CTERM sytem-associated; Region: pepcterm_export; TIGR03027 983545009714 SLBB domain; Region: SLBB; pfam10531 983545009715 Uncharacterized protein conserved in bacteria (DUF2320); Region: DUF2320; cl12051 983545009716 Undecaprenyl-phosphate glucose phosphotransferase; Region: WcaJ_sugtrans; TIGR03023 983545009717 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 983545009718 Bacterial sugar transferase; Region: Bac_transf; cl00939 983545009719 Glycosyl hydrolases family 8; Region: Glyco_hydro_8; cl01351 983545009720 alkyl hydroperoxide reductase subunit F; Provisional; Region: PRK15317 983545009721 Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) family, N-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which in turn catalyzes the reduction...; Region: AhpF_NTD_N; cd02974 983545009722 catalytic residue [active] 983545009723 TRX-GRX-like family, Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) subfamily, C-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which then...; Region: AhpF_NTD_C; cd03026 983545009724 catalytic residues [active] 983545009725 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 983545009726 peroxiredoxin; Region: AhpC; TIGR03137 983545009727 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 983545009728 dimer interface [polypeptide binding]; other site 983545009729 decamer (pentamer of dimers) interface [polypeptide binding]; other site 983545009730 catalytic triad [active] 983545009731 peroxidatic and resolving cysteines [active] 983545009732 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 983545009733 binding surface 983545009734 TPR motif; other site 983545009735 Tetratricopeptide repeat; Region: TPR_12; pfam13424 983545009736 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 983545009737 binding surface 983545009738 TPR motif; other site 983545009739 Gram-negative bacterial tonB protein; Region: TonB; cl10048 983545009740 Biopolymer transport protein ExbD/TolR; Region: ExbD; cl00537 983545009741 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 983545009742 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 983545009743 Protein of unknown function (DUF3450); Region: DUF3450; pfam11932 983545009744 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 983545009745 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 983545009746 N-terminal plug; other site 983545009747 ligand-binding site [chemical binding]; other site 983545009748 Cytochrome c; Region: Cytochrom_C; cl11414 983545009749 Iron permease FTR1 family; Region: FTR1; cl00475 983545009750 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 983545009751 TonB-dependent receptor; Region: TonB-Xanth-Caul; TIGR01782 983545009752 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl00284 983545009753 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl00284 983545009754 Peptidase M35 family; Region: M35_like; cl03449 983545009755 Domain of unknown function (DUF3329); Region: DUF3329; pfam11808 983545009756 phosphate regulon sensor protein; Provisional; Region: phoR; PRK11006 983545009757 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 983545009758 dimer interface [polypeptide binding]; other site 983545009759 phosphorylation site [posttranslational modification] 983545009760 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 983545009761 ATP binding site [chemical binding]; other site 983545009762 Mg2+ binding site [ion binding]; other site 983545009763 G-X-G motif; other site 983545009764 phosphate regulon transcriptional regulatory protein PhoB; Region: PhoB; TIGR02154 983545009765 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 983545009766 active site 983545009767 phosphorylation site [posttranslational modification] 983545009768 intermolecular recognition site; other site 983545009769 dimerization interface [polypeptide binding]; other site 983545009770 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 983545009771 DNA binding site [nucleotide binding] 983545009772 putative inner membrane diguanylate cyclase; Provisional; Region: PRK09966 983545009773 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: VicK; COG5002 983545009774 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080 983545009775 dimer interface [polypeptide binding]; other site 983545009776 phosphorylation site [posttranslational modification] 983545009777 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 983545009778 ATP binding site [chemical binding]; other site 983545009779 Mg2+ binding site [ion binding]; other site 983545009780 G-X-G motif; other site 983545009781 Putative exonuclease, RdgC; Region: RdgC; cl01122 983545009782 HDOD domain; Region: HDOD; pfam08668 983545009783 Nudix hydrolase homolog; Region: PLN02791 983545009784 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 983545009785 metal binding site [ion binding]; metal-binding site 983545009786 active site 983545009787 I-site; other site 983545009788 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 983545009789 Protein Kinase C Interacting protein related (PKCI): PKCI and related proteins belong to the ubiquitous HIT family of hydrolases that act on alpha-phosphates of ribonucleotides. The members of this subgroup have a conserved HxHxHxx motif (x is a...; Region: PKCI_related; cd01276 983545009790 nucleotide binding site/active site [active] 983545009791 HIT family signature motif; other site 983545009792 catalytic residue [active] 983545009793 Bacitracin resistance protein BacA; Region: BacA; cl00858 983545009794 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 983545009795 catalytic center binding site [active] 983545009796 ATP binding site [chemical binding]; other site 983545009797 Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534 983545009798 homooctamer interface [polypeptide binding]; other site 983545009799 active site 983545009800 Glycerol-3-phosphate acyltransferase; Region: G3P_acyltransf; cl00410 983545009801 UGMP family protein; Validated; Region: PRK09604 983545009802 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl14000 983545009803 Ribosomal protein S21; Region: Ribosomal_S21; cl00529 983545009804 GatB domain; Region: GatB_Yqey; cl11497 983545009805 DNA primase; Validated; Region: dnaG; PRK05667 983545009806 CHC2 zinc finger; Region: zf-CHC2; cl15369 983545009807 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 983545009808 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 983545009809 active site 983545009810 metal binding site [ion binding]; metal-binding site 983545009811 interdomain interaction site; other site 983545009812 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 983545009813 DNA primase DnaG DnaB-binding; Region: DnaG_DnaB_bind; cl07879 983545009814 RNA polymerase sigma factor RpoD; Validated; Region: PRK05658 983545009815 Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979 983545009816 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 983545009817 Sigma-70, non-essential region; Region: Sigma70_ner; pfam04546 983545009818 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 983545009819 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 983545009820 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 983545009821 DNA binding residues [nucleotide binding] 983545009822 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 983545009823 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 983545009824 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 983545009825 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 983545009826 Endonuclease I; Region: Endonuclease_1; cl01003 983545009827 Predicted extracellular nuclease [General function prediction only]; Region: COG2374 983545009828 YhcR_OBF_like: A subfamily of OB-fold domains similar to the OB folds of Bacillus subtilis YhcR. YhcR is a sugar-nonspecific nuclease, which is active in the presence of Ca2+ and Mn2+. It cleaves RNA endonucleolytically, producing 3'-monophosphate...; Region: YhcR_OBF_like; cd04486 983545009829 generic binding surface I; other site 983545009830 generic binding surface II; other site 983545009831 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 983545009832 putative catalytic site [active] 983545009833 putative metal binding site [ion binding]; other site 983545009834 putative phosphate binding site [ion binding]; other site 983545009835 RNase E inhibitor protein; Provisional; Region: PRK11191 983545009836 Protein of unknown function (DUF1260); Region: DUF1260; pfam06877 983545009837 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 983545009838 putative acyl-acceptor binding pocket; other site 983545009839 Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643 983545009840 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cl00086 983545009841 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 983545009842 Zn2+ binding site [ion binding]; other site 983545009843 Mg2+ binding site [ion binding]; other site 983545009844 nitrogen regulation protein NR(I); Provisional; Region: glnG; PRK10923 983545009845 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 983545009846 active site 983545009847 phosphorylation site [posttranslational modification] 983545009848 intermolecular recognition site; other site 983545009849 dimerization interface [polypeptide binding]; other site 983545009850 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 983545009851 Walker A motif; other site 983545009852 ATP binding site [chemical binding]; other site 983545009853 Walker B motif; other site 983545009854 arginine finger; other site 983545009855 Helix-turn-helix domains; Region: HTH; cl00088 983545009856 nitrogen regulation protein NR(II); Provisional; Region: glnL; PRK11073 983545009857 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 983545009858 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 983545009859 dimer interface [polypeptide binding]; other site 983545009860 phosphorylation site [posttranslational modification] 983545009861 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 983545009862 ATP binding site [chemical binding]; other site 983545009863 Mg2+ binding site [ion binding]; other site 983545009864 G-X-G motif; other site 983545009865 glutamine synthetase; Provisional; Region: glnA; PRK09469 983545009866 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 983545009867 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 983545009868 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 983545009869 GTP-binding protein TypA/BipA; Region: TypA_BipA; TIGR01394 983545009870 G1 box; other site 983545009871 putative GEF interaction site [polypeptide binding]; other site 983545009872 GTP/Mg2+ binding site [chemical binding]; other site 983545009873 Switch I region; other site 983545009874 G2 box; other site 983545009875 G3 box; other site 983545009876 Switch II region; other site 983545009877 G4 box; other site 983545009878 G5 box; other site 983545009879 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 983545009880 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 983545009881 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cl00197 983545009882 active site 983545009883 Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332 983545009884 active sites [active] 983545009885 tetramer interface [polypeptide binding]; other site 983545009886 urocanate hydratase; Provisional; Region: PRK05414 983545009887 histidine utilization repressor, proteobacterial; Region: his_ut_repres; TIGR02018 983545009888 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 983545009889 DNA-binding site [nucleotide binding]; DNA binding site 983545009890 UTRA domain; Region: UTRA; cl01230 983545009891 imidazolonepropionase; Validated; Region: PRK09356 983545009892 Imidazolonepropionase/imidazolone-5-propionate hydrolase (Imidazolone-5PH) catalyzes the third step in the histidine degradation pathway, the hydrolysis of (S)-3-(5-oxo-4,5-dihydro-3H-imidazol-4-yl)propanoate to N-formimidoyl-L-glutamate. In bacteria; Region: Imidazolone-5PH; cd01296 983545009893 active site 983545009894 Arginase family; Region: Arginase; cl00306 983545009895 NAD(P)H:FMN oxidoreductase family. This domain catalyzes the reduction of flavin, nitrocompound, quinones and azo compounds using NADH or NADPH as an electron donor. The enzyme is a homodimer, and each monomer binds a FMN as co-factor. This family...; Region: NfsB_like_nitroreductase; cd02149 983545009896 dimer interface [polypeptide binding]; other site 983545009897 FMN binding site [chemical binding]; other site 983545009898 Protein of unknown function (DUF2785); Region: DUF2785; pfam10978 983545009899 Ribosomal protein L17; Region: Ribosomal_L17; cl00356 983545009900 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 983545009901 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 983545009902 alphaNTD homodimer interface [polypeptide binding]; other site 983545009903 alphaNTD - beta interaction site [polypeptide binding]; other site 983545009904 alphaNTD - beta' interaction site [polypeptide binding]; other site 983545009905 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; cl11613 983545009906 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 983545009907 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 983545009908 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 983545009909 RNA binding surface [nucleotide binding]; other site 983545009910 Ribosomal protein S11; Region: Ribosomal_S11; cl00332 983545009911 Ribosomal protein S13/S18; Region: Ribosomal_S13; cl00331 983545009912 Ribosomal protein S13 [Translation, ribosomal structure and biogenesis]; Region: RpsM; COG0099 983545009913 Ribosomal protein L36; Region: Ribosomal_L36; cl00380 983545009914 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 983545009915 SecY translocase; Region: SecY; pfam00344 983545009916 Ribosomal protein L18e/L15; Region: Ribosomal_L18e; cl12022 983545009917 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 983545009918 23S rRNA binding site [nucleotide binding]; other site 983545009919 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 983545009920 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 983545009921 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 983545009922 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 983545009923 5S rRNA interface [nucleotide binding]; other site 983545009924 23S rRNA interface [nucleotide binding]; other site 983545009925 L5 interface [polypeptide binding]; other site 983545009926 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 983545009927 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 983545009928 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 983545009929 Ribosomal protein S8; Region: Ribosomal_S8; cl00330 983545009930 Ribosomal protein S14p/S29e; Region: Ribosomal_S14; cl00355 983545009931 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 983545009932 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 983545009933 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 983545009934 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 983545009935 KOW motif; Region: KOW; cl00354 983545009936 Ribosomal protein L14p/L23e; Region: Ribosomal_L14; cl00328 983545009937 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 983545009938 AMP-binding enzyme; Region: AMP-binding; cl15778 983545009939 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 983545009940 Helix-turn-helix domains; Region: HTH; cl00088 983545009941 The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 983545009942 dimerization interface [polypeptide binding]; other site 983545009943 substrate binding pocket [chemical binding]; other site 983545009944 23S rRNA (guanosine-2'-O-)-methyltransferase; Provisional; Region: PRK11181 983545009945 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; cl06870 983545009946 SpoU rRNA Methylase family; Region: SpoU_methylase; cl00362 983545009947 ribonuclease R; Region: RNase_R; TIGR02063 983545009948 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 983545009949 RNB domain; Region: RNB; pfam00773 983545009950 S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase play an important...; Region: S1_RNase_R; cd04471 983545009951 RNA binding site [nucleotide binding]; other site 983545009952 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 983545009953 Sel1 repeat; Region: Sel1; cl02723 983545009954 Phosphate-starvation-inducible E; Region: PsiE; cl01264 983545009955 FMN reductase; Validated; Region: fre; PRK08051 983545009956 NAD(P)H dependent flavin oxidoreductases use flavin as a substrate in mediating electron transfer from iron complexes or iron proteins. Structurally similar to ferredoxin reductases, but with only 15% sequence identity, flavin reductases reduce FAD, FMN; Region: flavin_oxioreductase; cd06189 983545009957 FAD binding pocket [chemical binding]; other site 983545009958 FAD binding motif [chemical binding]; other site 983545009959 phosphate binding motif [ion binding]; other site 983545009960 beta-alpha-beta structure motif; other site 983545009961 NAD binding pocket [chemical binding]; other site 983545009962 SpoU rRNA Methylase family; Region: SpoU_methylase; cl00362 983545009963 lysophospholipase L2; Provisional; Region: PRK10749 983545009964 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 983545009965 two-component sensor protein; Provisional; Region: cpxA; PRK09470 983545009966 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 983545009967 dimerization interface [polypeptide binding]; other site 983545009968 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 983545009969 dimer interface [polypeptide binding]; other site 983545009970 phosphorylation site [posttranslational modification] 983545009971 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 983545009972 ATP binding site [chemical binding]; other site 983545009973 Mg2+ binding site [ion binding]; other site 983545009974 G-X-G motif; other site 983545009975 DNA-binding transcriptional regulator CpxR; Provisional; Region: PRK10955 983545009976 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 983545009977 active site 983545009978 phosphorylation site [posttranslational modification] 983545009979 intermolecular recognition site; other site 983545009980 dimerization interface [polypeptide binding]; other site 983545009981 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 983545009982 DNA binding site [nucleotide binding] 983545009983 CpxP component of the bacterial Cpx-two-component system and related proteins; Region: CpxP_like; cl01482 983545009984 Methylglyoxal synthase catalyzes the enolization of dihydroxyacetone phosphate (DHAP) to produce methylglyoxal. The first part of the catalytic mechanism is believed to be similar to TIM (triosephosphate isomerase) in that both enzymes utilize DHAP to...; Region: MGS; cd01422 983545009985 active site 983545009986 dimer interfaces [polypeptide binding]; other site 983545009987 catalytic residues [active] 983545009988 Kelch motif; Region: Kelch_1; cl02701 983545009989 acetylornithine deacetylase; Provisional; Region: PRK05111 983545009990 M20 Peptidase acetylornithine deacetylase; Region: M20_ArgE; cd03894 983545009991 metal binding site [ion binding]; metal-binding site 983545009992 putative dimer interface [polypeptide binding]; other site 983545009993 N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436 983545009994 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 983545009995 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; cl15856 983545009996 AAK_NAGK-NC: N-Acetyl-L-glutamate kinase - noncyclic (NAGK-NC) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of microbial arginine biosynthesis using the acetylated, noncyclic route of...; Region: AAK_NAGK-NC; cd04249 983545009997 nucleotide binding site [chemical binding]; other site 983545009998 N-acetyl-L-glutamate binding site [chemical binding]; other site 983545009999 ornithine carbamoyltransferase; Provisional; Region: PRK14805 983545010000 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 983545010001 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 983545010002 Argininosuccinate synthase [Amino acid transport and metabolism]; Region: ArgG; COG0137 983545010003 Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate . In...; Region: Argininosuccinate_Synthase; cd01999 983545010004 ANP binding site [chemical binding]; other site 983545010005 Substrate Binding Site II [chemical binding]; other site 983545010006 Substrate Binding Site I [chemical binding]; other site 983545010007 argininosuccinate lyase; Provisional; Region: PRK04833 983545010008 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 983545010009 active sites [active] 983545010010 tetramer interface [polypeptide binding]; other site 983545010011 N-acetylglutamate synthase; Validated; Region: PRK05279 983545010012 AAK_NAGS-ABP: N-acetylglutamate (NAG) kinase-like domain of the NAG Synthase (NAGS) of the arginine-biosynthesis pathway (ABP) found in gamma- and beta-proteobacteria and higher plant chloroplasts. Domain architecture of these NAGS consisted of an...; Region: AAK_NAGS-ABP; cd04237 983545010013 putative feedback inhibition sensing region; other site 983545010014 putative nucleotide binding site [chemical binding]; other site 983545010015 putative substrate binding site [chemical binding]; other site 983545010016 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 983545010017 Coenzyme A binding pocket [chemical binding]; other site 983545010018 HopJ type III effector protein; Region: HopJ; pfam08888 983545010019 Flagellin N-methylase; Region: FliB; cl00497 983545010020 keto-hydroxyglutarate-aldolase/keto-deoxy- phosphogluconate aldolase; Provisional; Region: PRK05718 983545010021 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 983545010022 active site 983545010023 intersubunit interface [polypeptide binding]; other site 983545010024 catalytic residue [active] 983545010025 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 983545010026 glucokinase, proteobacterial type; Region: glk; TIGR00749 983545010027 Dehydratase family; Region: ILVD_EDD; cl00340 983545010028 6-phosphogluconate dehydratase; Region: edd; TIGR01196 983545010029 6PGL: 6-Phosphogluconolactonase (6PGL) subfamily; 6PGL catalyzes the second step of the oxidative phase of the pentose phosphate pathway, the hydrolyzation of 6-phosphoglucono-1,5-lactone (delta form) to 6-phosphogluconate. 6PGL is thought to guard...; Region: 6PGL; cd01400 983545010030 putative active site [active] 983545010031 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 983545010032 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 983545010033 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 983545010034 DNA-binding transcriptional regulator HexR; Provisional; Region: PRK11302 983545010035 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 983545010036 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 983545010037 putative active site [active] 983545010038 pyruvate kinase; Provisional; Region: PRK05826 983545010039 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl09155 983545010040 domain interfaces; other site 983545010041 active site 983545010042 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 983545010043 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 983545010044 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 983545010045 N-terminal plug; other site 983545010046 ligand-binding site [chemical binding]; other site 983545010047 Uncharacterized conserved protein [Function unknown]; Region: COG3268 983545010048 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 983545010049 NAD(P) binding pocket [chemical binding]; other site 983545010050 EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to...; Region: EFh; cd00051 983545010051 EF-hand domain pair; Region: EF_hand_5; pfam13499 983545010052 Ca2+ binding site [ion binding]; other site 983545010053 putative rhodanese-related sulfurtransferase; Provisional; Region: PRK00142 983545010054 Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YceA, Bacillus subtilis YbfQ, and similar uncharacterized proteins; Region: RHOD_YceA; cd01518 983545010055 active site residue [active] 983545010056 Protein of unknown function (DUF3718); Region: DUF3718; pfam12514 983545010057 RNA polymerase sigma factor, TIGR02999 family; Region: Sig-70_X6 983545010058 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 983545010059 active site 983545010060 ATP binding site [chemical binding]; other site 983545010061 substrate binding site [chemical binding]; other site 983545010062 activation loop (A-loop); other site 983545010063 Tetratricopeptide repeat; Region: TPR_12; pfam13424 983545010064 Tetratricopeptide repeat; Region: TPR_12; pfam13424 983545010065 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 983545010066 binding surface 983545010067 TPR motif; other site 983545010068 Tetratricopeptide repeat; Region: TPR_12; pfam13424 983545010069 Tetratricopeptide repeat; Region: TPR_12; pfam13424 983545010070 Protein of unknown function (DUF1329); Region: DUF1329; pfam07044 983545010071 Predicted exporters of the RND superfamily [General function prediction only]; Region: COG1033 983545010072 MASE1; Region: MASE1; pfam05231 983545010073 Predicted glutamine amidotransferase [General function prediction only]; Region: COG0121 983545010074 Glutamine amidotransferases class-II (Gn-AT)_YafJ-type. YafJ is a glutamine amidotransferase-like protein of unknown function found in prokaryotes, eukaryotes and archaea. YafJ has a conserved structural fold similar to those of other class II...; Region: YafJ; cd01908 983545010075 putative active site [active] 983545010076 putative dimer interface [polypeptide binding]; other site 983545010077 NIPSNAP; Region: NIPSNAP; pfam07978 983545010078 Putative peptidoglycan binding domain; Region: PG_binding_1; cl15437 983545010079 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 983545010080 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 983545010081 NAD(P) binding site [chemical binding]; other site 983545010082 active site 983545010083 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 983545010084 3-hydroxyisobutyrate dehydrogenase; Region: HIBADH; TIGR01692 983545010085 3-hydroxyisobutyryl-CoA hydrolase; Provisional; Region: PRK05617 983545010086 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 983545010087 substrate binding site [chemical binding]; other site 983545010088 oxyanion hole (OAH) forming residues; other site 983545010089 trimer interface [polypeptide binding]; other site 983545010090 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cl15762 983545010091 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 983545010092 Isobutyryl-CoA dehydrogenase; Region: IBD; cd01162 983545010093 substrate binding pocket [chemical binding]; other site 983545010094 FAD binding site [chemical binding]; other site 983545010095 catalytic base [active] 983545010096 Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085 983545010097 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 983545010098 tetrameric interface [polypeptide binding]; other site 983545010099 NAD binding site [chemical binding]; other site 983545010100 catalytic residues [active] 983545010101 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 983545010102 active site 983545010103 phosphorylation site [posttranslational modification] 983545010104 intermolecular recognition site; other site 983545010105 dimerization interface [polypeptide binding]; other site 983545010106 cellulose synthase subunit BcsC; Provisional; Region: PRK11447 983545010107 Lipid A 3-O-deacylase (PagL); Region: PagL; pfam09411 983545010108 renal dipeptidase (rDP), best studied in mammals and also called membrane or microsomal dipeptidase, is a membrane-bound glycoprotein hydrolyzing dipeptides and is involved in hydrolytic metabolism of penem and carbapenem beta-lactam antibiotics; Region: rDP_like; cd01301 983545010109 active site 983545010110 dimer interface [polypeptide binding]; other site 983545010111 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 983545010112 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 983545010113 N-terminal plug; other site 983545010114 ligand-binding site [chemical binding]; other site 983545010115 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 983545010116 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 983545010117 N-terminal plug; other site 983545010118 ligand-binding site [chemical binding]; other site 983545010119 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 983545010120 Septum formation topological specificity factor MinE; Region: MinE; cl00538 983545010121 Bacterial cell division requires the formation of a septum at mid-cell. The site is determined by the min operon products MinC, MinD and MinE. MinC is a nonspecific inhibitor of the septum protein FtsZ. MinE is the supressor of MinC. MinD plays a pivotal...; Region: MinD; cd02036 983545010122 CobQ/CobB/MinD/ParA nucleotide binding domain; Region: CbiA; pfam01656 983545010123 Switch I; other site 983545010124 Switch II; other site 983545010125 Septum formation inhibitor MinC, N-terminal domain; Region: MinC_N; pfam05209 983545010126 septum formation inhibitor; Reviewed; Region: minC; PRK00339 983545010127 Septum formation inhibitor MinC, C-terminal domain; Region: MinC_C; pfam03775 983545010128 putative enoyl-[acyl-carrier-protein] reductase II; Region: enACPred_II; TIGR03151 983545010129 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 983545010130 FMN binding site [chemical binding]; other site 983545010131 substrate binding site [chemical binding]; other site 983545010132 putative catalytic residue [active] 983545010133 GST_N family, Class Zeta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens; Region: GST_N_Zeta; cd03042 983545010134 maleylacetoacetate isomerase; Region: maiA; TIGR01262 983545010135 C-terminal domain interface [polypeptide binding]; other site 983545010136 GSH binding site (G-site) [chemical binding]; other site 983545010137 putative dimer interface [polypeptide binding]; other site 983545010138 C-terminal, alpha helical domain of Class Zeta Glutathione S-transferases; Region: GST_C_Zeta; cd03191 983545010139 dimer interface [polypeptide binding]; other site 983545010140 N-terminal domain interface [polypeptide binding]; other site 983545010141 maleylacetoacetate (MAA) substrate binding site (H site) [chemical binding]; other site 983545010142 fumarylacetoacetase; Region: fum_ac_acetase; TIGR01266 983545010143 Domain of unknown function (DUF1969); Region: DUF1969; pfam09298 983545010144 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 983545010145 Cupin domain; Region: Cupin_2; cl09118 983545010146 Sodium:solute symporter family; Region: SSF; cl00456 983545010147 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 983545010148 Protein of unknown function, DUF485; Region: DUF485; cl01231 983545010149 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 983545010150 Sulfatase; Region: Sulfatase; cl10460 983545010151 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 983545010152 Sulfatase; Region: Sulfatase; cl10460 983545010153 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 983545010154 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 983545010155 N-terminal plug; other site 983545010156 ligand-binding site [chemical binding]; other site 983545010157 Transcriptional regulator [Transcription]; Region: LysR; COG0583 983545010158 Helix-turn-helix domains; Region: HTH; cl00088 983545010159 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 983545010160 dimerization interface [polypeptide binding]; other site 983545010161 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 983545010162 5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase; Provisional; Region: PRK08575 983545010163 substrate binding site [chemical binding]; other site 983545010164 THF binding site; other site 983545010165 zinc-binding site [ion binding]; other site 983545010166 Domain of unknown function (DUF1852); Region: DUF1852; pfam08908 983545010167 Domain of unknown function DUF20; Region: UPF0118; pfam01594 983545010168 pheromone autoinducer 2 transporter; Reviewed; Region: tqsA; cl00465 983545010169 2-dehydro-3-deoxy-6-phosphogalactonate aldolase; Reviewed; Region: PRK09140 983545010170 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 983545010171 active site 983545010172 intersubunit interface [polypeptide binding]; other site 983545010173 catalytic residue [active] 983545010174 glycosyl hydrolase family 16; Region: Glyco_hydrolase_16; cl00218 983545010175 active site 983545010176 catalytic residues [active] 983545010177 Bacterial Ig-like domain (group 2); Region: Big_2; cl02708 983545010178 Carbohydrate binding domain; Region: CBM_4_9; pfam02018 983545010179 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 983545010180 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 983545010181 substrate binding site [chemical binding]; other site 983545010182 ATP binding site [chemical binding]; other site 983545010183 putative transporter; Provisional; Region: PRK10484 983545010184 Sodium:solute symporter family; Region: SSF; cl00456 983545010185 Mannitol-1-phosphate/altronate dehydrogenases [Carbohydrate transport and metabolism]; Region: MtlD; COG0246 983545010186 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 983545010187 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 983545010188 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; cl08371 983545010189 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 983545010190 Cellulase (glycosyl hydrolase family 5); Region: Cellulase; cl15381 983545010191 Alpha-L-fucosidase; Region: Alpha_L_fucos; cl12119 983545010192 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 983545010193 Sulfatase; Region: Sulfatase; cl10460 983545010194 Sulfatase; Region: Sulfatase; cl10460 983545010195 Cupin domain; Region: Cupin_2; cl09118 983545010196 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 983545010197 Helix-turn-helix domain; Region: HTH_18; pfam12833 983545010198 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 983545010199 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 983545010200 Sulfatase; Region: Sulfatase; cl10460 983545010201 Bacterial Ig-like domain (group 2); Region: Big_2; cl02708 983545010202 Probable beta-xylosidase; Provisional; Region: PLN03080 983545010203 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971 983545010204 Glycosyl hydrolase family 3 C-terminal domain; Region: Glyco_hydro_3_C; pfam01915 983545010205 Fibronectin type III-like domain; Region: Fn3-like; cl15273 983545010206 Beta-agarase, member of glycosyl hydrolase family 16; Region: GH16_beta_agarase; cd02178 983545010207 calcium binding site [ion binding]; other site 983545010208 active site 983545010209 catalytic residues [active] 983545010210 Alpha-L-fucosidase; Region: Alpha_L_fucos; cl12119 983545010211 Alpha-L-fucosidase [Carbohydrate transport and metabolism]; Region: COG3669 983545010212 Domain of unknown function (DUF718); Region: DUF718; cl01281 983545010213 beta-D-galactosidase; Reviewed; Region: lacZ; PRK09525 983545010214 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; cl08371 983545010215 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 983545010216 Cellulase (glycosyl hydrolase family 5); Region: Cellulase; cl15381 983545010217 Beta galactosidase small chain; Region: Bgal_small_N; cl03787 983545010218 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 983545010219 Sulfatase; Region: Sulfatase; cl10460 983545010220 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 983545010221 Sulfatase; Region: Sulfatase; cl10460 983545010222 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 983545010223 Sulfatase; Region: Sulfatase; cl10460 983545010224 HEAT repeats; Region: HEAT_2; pfam13646 983545010225 Cupin domain; Region: Cupin_2; cl09118 983545010226 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 983545010227 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 983545010228 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 983545010229 Cytochrome c; Region: Cytochrom_C; cl11414 983545010230 Cytochrome c; Region: Cytochrom_C; cl11414 983545010231 Protein of unknown function (DUF1549); Region: PSCyt2; pfam07583 983545010232 Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of...; Region: LamG; cl00102 983545010233 Protein of unknown function (DUF1553); Region: PSD1; pfam07587 983545010234 Protein of unknown function (DUF1501); Region: DUF1501; pfam07394 983545010235 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; cl01155 983545010236 glycosyl hydrolase family 16; Region: Glyco_hydrolase_16; cl00218 983545010237 putative membrane-bound dehydrogenase domain; Region: Piru_Ver_Nterm; TIGR02604 983545010238 Outer membrane receptor for ferrienterochelin and colicins [Inorganic ion transport and metabolism]; Region: FepA; COG4771 983545010239 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 983545010240 N-terminal plug; other site 983545010241 ligand-binding site [chemical binding]; other site 983545010242 Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647 983545010243 active site 983545010244 glycosyl hydrolase family 16; Region: Glyco_hydrolase_16; cl00218 983545010245 Glycosyl hydrolase family 43, includes arabinoxylan arabinofuranohydrolase, beta-xylosidase, endo-1,4-beta-xylanase, alpha-L-arabinofuranosidase; Region: GH43_AXH_like; cd08990 983545010246 substrate binding site [chemical binding]; other site 983545010247 active site 983545010248 Carbohydrate Binding Module 6 (CBM6); many are appended to glycoside hydrolase (GH) family 11 and GH43 xylanase domains; Region: CBM6_xylanase-like; cd04084 983545010249 metal binding site [ion binding]; metal-binding site 983545010250 ligand binding site [chemical binding]; other site 983545010251 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl00284 983545010252 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl00284 983545010253 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl00284 983545010254 Bacterial Ig-like domain (group 2); Region: Big_2; cl02708 983545010255 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 983545010256 DNA polymerase I; Provisional; Region: PRK05755 983545010257 Beta-agarase, member of glycosyl hydrolase family 16; Region: GH16_beta_agarase; cd02178 983545010258 calcium binding site [ion binding]; other site 983545010259 active site 983545010260 catalytic residues [active] 983545010261 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; cl08371 983545010262 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 983545010263 Cellulase (glycosyl hydrolase family 5); Region: Cellulase; cl15381 983545010264 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 983545010265 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 983545010266 Fucose permease [Carbohydrate transport and metabolism]; Region: FucP; COG0738 983545010267 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cl11420 983545010268 SAF domain; Region: SAF; cl00555 983545010269 Altronate dehydratase [Carbohydrate transport and metabolism]; Region: UxaA; COG2721 983545010270 D-galactarate dehydratase / Altronate hydrolase, C terminus; Region: GD_AH_C; pfam04295 983545010271 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 983545010272 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 983545010273 active site 983545010274 catalytic tetrad [active] 983545010275 Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG3618 983545010276 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 983545010277 active site 983545010278 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 983545010279 Alcohol dehydrogenases of the MDR family; Region: Zn_ADH7; cd08261 983545010280 putative NAD(P) binding site [chemical binding]; other site 983545010281 catalytic Zn binding site [ion binding]; other site 983545010282 structural Zn binding site [ion binding]; other site 983545010283 Transcriptional regulator [Transcription]; Region: IclR; COG1414 983545010284 Helix-turn-helix domains; Region: HTH; cl00088 983545010285 Sulfatase; Region: Sulfatase; cl10460 983545010286 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 983545010287 DNA polymerase III PolC; Validated; Region: polC; PRK00448 983545010288 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 983545010289 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 983545010290 RDD family; Region: RDD; cl00746 983545010291 Predicted permeases [General function prediction only]; Region: COG0795; cl12074 983545010292 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 983545010293 Predicted permeases [General function prediction only]; Region: COG0795; cl12074 983545010294 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 983545010295 multifunctional aminopeptidase A; Provisional; Region: PRK00913 983545010296 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 983545010297 interface (dimer of trimers) [polypeptide binding]; other site 983545010298 Substrate-binding/catalytic site; other site 983545010299 Zn-binding sites [ion binding]; other site 983545010300 DNA polymerase III chi subunit, HolC; Region: DNA_pol3_chi; cl01106 983545010301 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 983545010302 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 983545010303 HIGH motif; other site 983545010304 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 983545010305 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 983545010306 active site 983545010307 KMSKS motif; other site 983545010308 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 983545010309 tRNA binding surface [nucleotide binding]; other site 983545010310 anticodon binding site; other site 983545010311 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 983545010312 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 983545010313 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 983545010314 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 983545010315 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 983545010316 metal binding site [ion binding]; metal-binding site 983545010317 active site 983545010318 I-site; other site 983545010319 Protein of unknown function (DUF3016); Region: DUF3016; pfam11454 983545010320 MltA-interacting protein MipA; Region: MipA; cl01504 983545010321 Protein of unknown function (DUF3019); Region: DUF3019; pfam11456 983545010322 DNA-binding transcriptional regulator RstA; Provisional; Region: PRK10701 983545010323 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 983545010324 active site 983545010325 phosphorylation site [posttranslational modification] 983545010326 intermolecular recognition site; other site 983545010327 dimerization interface [polypeptide binding]; other site 983545010328 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 983545010329 DNA binding site [nucleotide binding] 983545010330 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 983545010331 dimer interface [polypeptide binding]; other site 983545010332 phosphorylation site [posttranslational modification] 983545010333 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 983545010334 ATP binding site [chemical binding]; other site 983545010335 Mg2+ binding site [ion binding]; other site 983545010336 G-X-G motif; other site 983545010337 cytochrome c oxidase accessory protein FixG; Region: ccoG_rdxA_fixG; TIGR02745 983545010338 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 983545010339 Ubp3 associated protein Bre5; Region: Bre5; pfam11614 983545010340 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 983545010341 Phosphotransferase enzyme family; Region: APH; pfam01636 983545010342 DsbA family, DsbA subfamily; DsbA is a monomeric thiol disulfide oxidoreductase protein containing a redox active CXXC motif imbedded in a TRX fold. It is involved in the oxidative protein folding pathway in prokaryotes, and is the strongest thiol...; Region: DsbA_DsbA; cd03019 983545010343 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 983545010344 catalytic residues [active] 983545010345 hinge region; other site 983545010346 alpha helical domain; other site 983545010347 MASE1; Region: MASE1; pfam05231 983545010348 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 983545010349 metal binding site [ion binding]; metal-binding site 983545010350 active site 983545010351 I-site; other site 983545010352 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 983545010353 ligand binding site [chemical binding]; other site 983545010354 active site 983545010355 UGI interface [polypeptide binding]; other site 983545010356 catalytic site [active] 983545010357 Threonine synthase [Amino acid transport and metabolism]; Region: ThrC; COG0498 983545010358 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342 983545010359 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 983545010360 catalytic residue [active] 983545010361 homoserine kinase; Provisional; Region: PRK01212 983545010362 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 983545010363 bifunctional aspartokinase I/homoserine dehydrogenase I; Provisional; Region: thrA; PRK09436 983545010364 AAK_AK-HSDH: Amino Acid Kinase Superfamily (AAK), AK-HSDH; this CD includes the N-terminal catalytic domain of aspartokinase (AK) of the bifunctional enzyme AK - homoserine dehydrogenase (HSDH). These aspartokinases are found in bacteria (E. coli...; Region: AAK_AK-HSDH; cd04257 983545010365 putative catalytic residues [active] 983545010366 putative nucleotide binding site [chemical binding]; other site 983545010367 putative aspartate binding site [chemical binding]; other site 983545010368 ACT domains of the bifunctional enzyme aspartokinase (AK) - homoserine dehydrogenase (HSDH); Region: ACT_AKi-HSDH-ThrA-like_1; cd04921 983545010369 dimer interface [polypeptide binding]; other site 983545010370 putative threonine allosteric regulatory site; other site 983545010371 ACT domains of the bifunctional enzyme aspartokinase (AK) - homoserine dehydrogenase (HSDH); Region: ACT_AKi-HSDH-ThrA_2; cd04922 983545010372 putative threonine allosteric regulatory site; other site 983545010373 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 983545010374 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 983545010375 Antibiotic biosynthesis monooxygenase; Region: ABM; cl10022 983545010376 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 983545010377 Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR7; cd08276 983545010378 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 983545010379 putative NAD(P) binding site [chemical binding]; other site 983545010380 Protein of unknown function (DUF1329); Region: DUF1329; pfam07044 983545010381 Uncharacterized protein related to plant photosystem II stability/assembly factor [General function prediction only]; Region: COG4447 983545010382 Protein of unknown function (DUF1329); Region: DUF1329; pfam07044 983545010383 Predicted exporters of the RND superfamily [General function prediction only]; Region: COG1033 983545010384 acetoacetyl-CoA synthetase; Provisional; Region: PRK03584 983545010385 Domain of unknown function (DUF3448); Region: DUF3448; pfam11930 983545010386 AMP-binding enzyme; Region: AMP-binding; cl15778 983545010387 N-methylhydantoinase B/acetone carboxylase, alpha subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuB; COG0146 983545010388 N-methylhydantoinase A/acetone carboxylase, beta subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuA; COG0145 983545010389 Hydantoinase/oxoprolinase N-terminal region; Region: Hydant_A_N; pfam05378 983545010390 Hydantoinase/oxoprolinase; Region: Hydantoinase_A; cl00668 983545010391 Acetone carboxylase gamma subunit; Region: Acetone_carb_G; pfam08882 983545010392 Acetone carboxylase, gamma subunit [Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcxC; COG4647 983545010393 N-methylhydantoinase A/acetone carboxylase, beta subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuA; COG0145 983545010394 Hydantoinase/oxoprolinase N-terminal region; Region: Hydant_A_N; pfam05378 983545010395 Hydantoinase/oxoprolinase; Region: Hydantoinase_A; cl00668 983545010396 Putative NADP-dependent oxidoreductases [General function prediction only]; Region: COG2130 983545010397 Prostaglandin dehydrogenases; Region: PGDH; cd05288 983545010398 NAD(P) binding site [chemical binding]; other site 983545010399 substrate binding site [chemical binding]; other site 983545010400 dimer interface [polypeptide binding]; other site 983545010401 ATP-dependent transcriptional regulator [Transcription]; Region: MalT; COG2909 983545010402 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 983545010403 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 983545010404 DNA binding residues [nucleotide binding] 983545010405 dimerization interface [polypeptide binding]; other site 983545010406 Helix-turn-helix domains; Region: HTH; cl00088 983545010407 glycine dehydrogenase; Provisional; Region: PRK05367 983545010408 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 983545010409 tetramer interface [polypeptide binding]; other site 983545010410 pyridoxal 5'-phosphate binding site [chemical binding]; other site 983545010411 catalytic residue [active] 983545010412 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 983545010413 tetramer interface [polypeptide binding]; other site 983545010414 pyridoxal 5'-phosphate binding site [chemical binding]; other site 983545010415 catalytic residue [active] 983545010416 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 983545010417 lipoyl attachment site [posttranslational modification]; other site 983545010418 glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389 983545010419 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 983545010420 Transcriptional regulator [Transcription]; Region: LysR; COG0583 983545010421 Helix-turn-helix domains; Region: HTH; cl00088 983545010422 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 983545010423 dimerization interface [polypeptide binding]; other site 983545010424 putative secretion ATPase, PEP-CTERM locus subfamily; Region: pepcterm_ATPase; TIGR03015 983545010425 Haemolysin-III related; Region: HlyIII; cl03831 983545010426 WYL domain; Region: WYL; cl14852 983545010427 The GIY-YIG domain of uncharacterized protein family UPF0213 related to structure-specific endonuclease SLX1; Region: GIY-YIG_UPF0213; cd10456 983545010428 GIY-YIG motif/motif A; other site 983545010429 putative active site [active] 983545010430 putative metal binding site [ion binding]; other site 983545010431 bifunctional glutamine-synthetase adenylyltransferase/deadenyltransferase; Reviewed; Region: PRK11072 983545010432 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 983545010433 metal binding triad; other site 983545010434 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 983545010435 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 983545010436 metal binding triad; other site 983545010437 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 983545010438 Toxin co-regulated pilus biosynthesis protein Q; Region: TcpQ; pfam10671 983545010439 Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279 983545010440 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 983545010441 putative acyl-acceptor binding pocket; other site 983545010442 PAS domain; Region: PAS_9; pfam13426 983545010443 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 983545010444 PAS fold; Region: PAS_3; pfam08447 983545010445 putative active site [active] 983545010446 heme pocket [chemical binding]; other site 983545010447 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 983545010448 PAS domain; Region: PAS_9; pfam13426 983545010449 putative active site [active] 983545010450 heme pocket [chemical binding]; other site 983545010451 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 983545010452 PAS domain; Region: PAS_9; pfam13426 983545010453 putative active site [active] 983545010454 heme pocket [chemical binding]; other site 983545010455 Osmosensitive K+ channel histidine kinase [Signal transduction mechanisms]; Region: KdpD; COG2205 983545010456 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 983545010457 dimer interface [polypeptide binding]; other site 983545010458 phosphorylation site [posttranslational modification] 983545010459 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 983545010460 ATP binding site [chemical binding]; other site 983545010461 Mg2+ binding site [ion binding]; other site 983545010462 G-X-G motif; other site 983545010463 Response regulator receiver domain; Region: Response_reg; pfam00072 983545010464 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 983545010465 active site 983545010466 phosphorylation site [posttranslational modification] 983545010467 intermolecular recognition site; other site 983545010468 dimerization interface [polypeptide binding]; other site 983545010469 Response regulator receiver domain; Region: Response_reg; pfam00072 983545010470 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 983545010471 active site 983545010472 phosphorylation site [posttranslational modification] 983545010473 intermolecular recognition site; other site 983545010474 dimerization interface [polypeptide binding]; other site 983545010475 Protein of unknown function (DUF3081); Region: DUF3081; pfam11280 983545010476 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 983545010477 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 983545010478 ChaB; Region: ChaB; cl01887 983545010479 Protein of unknown function (DUF808); Region: DUF808; cl01002 983545010480 Putative catalytic domain of family 2 polysaccharide deacetylases (DACs) from bacteria; Region: CE4_DAC2; cd10936 983545010481 NodB motif; other site 983545010482 putative active site [active] 983545010483 putative catalytic site [active] 983545010484 Zn binding site [ion binding]; other site 983545010485 Membrane-bound metallopeptidase [Cell division and chromosome partitioning]; Region: COG4942 983545010486 Sulfatase; Region: Sulfatase; cl10460 983545010487 Phosphoglyceromutase [Carbohydrate transport and metabolism]; Region: GpmI; COG0696 983545010488 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 983545010489 active site residue [active] 983545010490 Glutaredoxin (GRX) family, GRX bacterial class 1 and 3 (b_1_3)-like subfamily; composed of bacterial GRXs, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, catalyzing the...; Region: GRX_GRXb_1_3_like; cd03418 983545010491 GSH binding site [chemical binding]; other site 983545010492 catalytic residues [active] 983545010493 Preprotein translocase subunit SecB. SecB is a cytoplasmic component of the multisubunit membrane-bound enzyme termed Sec protein translocase, which is the main constituent of the General Secretory (type II) Pathway involved in translocation of nascent...; Region: Translocase_SecB; cd00557 983545010494 SecA binding site; other site 983545010495 Preprotein binding site; other site 983545010496 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 983545010497 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 983545010498 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 983545010499 hypothetical protein; Provisional; Region: PRK11383 983545010500 yiaA/B two helix domain; Region: YiaAB; cl01759 983545010501 yiaA/B two helix domain; Region: YiaAB; cl01759 983545010502 Uncharacterized protein conserved in bacteria (DUF2145); Region: DUF2145; pfam09916 983545010503 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 983545010504 Protein of unknown function (DUF328); Region: DUF328; cl01143 983545010505 Macro domain, a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ADP-ribose polymerases). Some macro domains recognize poly...; Region: Macro; cl00019 983545010506 transaldolase-like protein; Provisional; Region: PTZ00411 983545010507 Transaldolases including both TalA and TalB; Region: Transaldolase_TalAB; cd00957 983545010508 active site 983545010509 dimer interface [polypeptide binding]; other site 983545010510 catalytic residue [active] 983545010511 glucose-6-phosphate isomerase; Reviewed; Region: pgi; PRK00179 983545010512 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 983545010513 active site 983545010514 dimer interface [polypeptide binding]; other site 983545010515 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 983545010516 dimer interface [polypeptide binding]; other site 983545010517 active site 983545010518 Protein of unknown function (DUF2955); Region: DUF2955; pfam11168 983545010519 Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566 983545010520 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 983545010521 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 983545010522 transcriptional regulator SlyA; Provisional; Region: PRK03573 983545010523 Helix-turn-helix domains; Region: HTH; cl00088 983545010524 TonB-dependent heme/hemoglobin receptor family protein; Region: TonB-hemin; TIGR01785 983545010525 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 983545010526 N-terminal plug; other site 983545010527 ligand-binding site [chemical binding]; other site 983545010528 Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities [Amino acid transport and metabolism]; Region: MalY; COG1168 983545010529 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 983545010530 pyridoxal 5'-phosphate binding site [chemical binding]; other site 983545010531 homodimer interface [polypeptide binding]; other site 983545010532 catalytic residue [active] 983545010533 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 983545010534 active site 983545010535 phosphorylation site [posttranslational modification] 983545010536 intermolecular recognition site; other site 983545010537 dimerization interface [polypeptide binding]; other site 983545010538 DNA polymerase II; Reviewed; Region: PRK05762 983545010539 DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase II and similar bacterial family-B DNA polymerases; Region: DNA_polB_II_exo; cd05784 983545010540 active site 983545010541 catalytic site [active] 983545010542 substrate binding site [chemical binding]; other site 983545010543 DNA polymerase type-II subfamily catalytic domain. Bacteria contain five DNA polymerases (I, II, III, IV and V). DNA polymerase II (Pol II) is a prototype for the B-family of polymerases. The role of Pol II in a variety of cellular activities, such as...; Region: POLBc_Pol_II; cd05537 983545010544 active site 983545010545 metal-binding site 983545010546 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 983545010547 metal binding site [ion binding]; metal-binding site 983545010548 active site 983545010549 I-site; other site 983545010550 Protein of unknown function (DUF3718); Region: DUF3718; pfam12514 983545010551 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 983545010552 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; cl11611 983545010553 GTPase YlqF; Reviewed; Region: rbgA; PRK09563 983545010554 Circularly permuted YlqF GTPase; Region: YlqF; cd01856 983545010555 GTP/Mg2+ binding site [chemical binding]; other site 983545010556 G4 box; other site 983545010557 G5 box; other site 983545010558 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 983545010559 G1 box; other site 983545010560 Switch I region; other site 983545010561 G2 box; other site 983545010562 G3 box; other site 983545010563 Switch II region; other site 983545010564 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 983545010565 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 983545010566 N-terminal plug; other site 983545010567 ligand-binding site [chemical binding]; other site 983545010568 Putative MetA-pathway of phenol degradation; Region: Phenol_MetA_deg; cl01768 983545010569 TonB-dependent receptor; Region: TonB-Xanth-Caul; TIGR01782 983545010570 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl00284 983545010571 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 983545010572 ligand-binding site [chemical binding]; other site 983545010573 Alginate lyase; Region: Alginate_lyase2; pfam08787 983545010574 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 983545010575 classical (c) SDRs; Region: SDR_c; cd05233 983545010576 NAD(P) binding site [chemical binding]; other site 983545010577 active site 983545010578 RbsD / FucU transport protein family; Region: RbsD_FucU; cl00809 983545010579 manganese transport protein MntH; Reviewed; Region: PRK00701; cl15845 983545010580 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 983545010581 Gluconate kinase (GntK) catalyzes the phosphoryl transfer from ATP to gluconate. The resulting product gluconate-6-phoshate is an important precursor of gluconate metabolism. GntK acts as a dimmer composed of two identical subunits; Region: GntK; cd02021 983545010582 Gluconate kinase [Carbohydrate transport and metabolism]; Region: GntK; COG3265 983545010583 ATP-binding site [chemical binding]; other site 983545010584 Gluconate-6-phosphate binding site [chemical binding]; other site 983545010585 Alginate lyase; Region: Alginate_lyase2; pfam08787 983545010586 Phosphomannose isomerase [Carbohydrate transport and metabolism]; Region: ManA; COG1482 983545010587 Phosphomannose isomerase type I; Region: PMI_typeI; cl15429 983545010588 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 983545010589 manganese transport protein MntH; Reviewed; Region: PRK00701; cl15845 983545010590 mannonate dehydratase; Provisional; Region: PRK03906 983545010591 mannonate dehydratase; Region: uxuA; TIGR00695 983545010592 TonB-dependent receptor; Region: TonB-Xanth-Caul; TIGR01782 983545010593 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl00284 983545010594 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl00284 983545010595 Alginate Lyase A1-III; enzymatically depolymerizes alginate, a complex copolymer of beta-D-mannuronate and alpha-L-guluronate, by cleaving the beta-(1,4) glycosidic bond; Region: AlgLyase; cl00179 983545010596 Heparinase II/III-like protein; Region: Hepar_II_III; cl15421 983545010597 Cation efflux family; Region: Cation_efflux; cl00316 983545010598 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 983545010599 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 983545010600 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 983545010601 metal binding site [ion binding]; metal-binding site 983545010602 active site 983545010603 I-site; other site 983545010604 NAD(P) transhydrogenase beta subunit; Region: PNTB; pfam02233 983545010605 NAD/NADP transhydrogenase beta subunit [Energy production and conversion]; Region: PntB; cl00566 983545010606 Domain of unknown function (DUF3814); Region: DUF3814; pfam12769 983545010607 NAD/NADP transhydrogenase alpha subunit [Energy production and conversion]; Region: PntA; COG3288 983545010608 Alanine dehydrogenase/PNT, N-terminal domain; Region: AlaDh_PNT_N; cl15379 983545010609 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 983545010610 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 983545010611 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 983545010612 substrate binding site [chemical binding]; other site 983545010613 ATP binding site [chemical binding]; other site 983545010614 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 983545010615 D-galactonate transporter; Region: 2A0114; TIGR00893 983545010616 putative substrate translocation pore; other site 983545010617 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 983545010618 Periplasmic copper-binding protein (NosD); Region: NosD; pfam05048 983545010619 Transcriptional regulators [Transcription]; Region: FadR; COG2186 983545010620 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 983545010621 DNA-binding site [nucleotide binding]; DNA binding site 983545010622 FCD domain; Region: FCD; cl11656 983545010623 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 983545010624 classical (c) SDRs; Region: SDR_c; cd05233 983545010625 NAD(P) binding site [chemical binding]; other site 983545010626 active site 983545010627 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 983545010628 FAD binding domain; Region: FAD_binding_3; pfam01494 983545010629 CorA-like Mg2+ transporter protein; Region: CorA; pfam01544 983545010630 magnesium/nickel/cobalt transporter CorA; Provisional; Region: PRK11085; cl00459 983545010631 ribosomal protein S6 modification protein; Provisional; Region: PRK10446 983545010632 ATP-grasp domain; Region: ATP-grasp_4; cl03087 983545010633 Putative ATP-dependant zinc protease; Region: Zn_protease; cl01682 983545010634 Lipid A 3-O-deacylase (PagL); Region: PagL; pfam09411 983545010635 Response regulator receiver domain; Region: Response_reg; pfam00072 983545010636 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 983545010637 active site 983545010638 phosphorylation site [posttranslational modification] 983545010639 intermolecular recognition site; other site 983545010640 dimerization interface [polypeptide binding]; other site 983545010641 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 983545010642 metal binding site [ion binding]; metal-binding site 983545010643 active site 983545010644 I-site; other site 983545010645 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 983545010646 Helix-turn-helix domains; Region: HTH; cl00088 983545010647 Mechanosensitive ion channel; Region: MS_channel; pfam00924 983545010648 Uncharacterized oxidoreductases, Fe-dependent alcohol dehydrogenase family [Energy production and conversion]; Region: COG1979 983545010649 Butanol dehydrogenase catalyzes the conversion of butyraldehyde to butanol with the cofactor NAD(P)H being oxidized in the process; Region: BDH; cd08187 983545010650 dimer interface [polypeptide binding]; other site 983545010651 active site 983545010652 metal binding site [ion binding]; metal-binding site 983545010653 AraC-type transcriptional regulator N-terminus; Region: AraC_N; pfam06719 983545010654 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 983545010655 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 983545010656 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 983545010657 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 983545010658 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 983545010659 Chemotaxis phosphatase CheX; Region: CheX; cl15816 983545010660 Response regulator receiver domain; Region: Response_reg; pfam00072 983545010661 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 983545010662 active site 983545010663 phosphorylation site [posttranslational modification] 983545010664 intermolecular recognition site; other site 983545010665 dimerization interface [polypeptide binding]; other site 983545010666 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 983545010667 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 983545010668 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; cl03161 983545010669 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 983545010670 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 983545010671 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 983545010672 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cl00159 983545010673 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 983545010674 putative S-transferase; Provisional; Region: PRK11752 983545010675 GST_N family, Ure2p-like subfamily; composed of the Saccharomyces cerevisiae Ure2p and related GSTs. Ure2p is a regulator for nitrogen catabolism in yeast. It represses the expression of several gene products involved in the use of poor nitrogen sources...; Region: GST_N_Ure2p_like; cd03048 983545010676 C-terminal domain interface [polypeptide binding]; other site 983545010677 GSH binding site (G-site) [chemical binding]; other site 983545010678 dimer interface [polypeptide binding]; other site 983545010679 C-terminal, alpha helical domain of Escherichia coli Yghu Glutathione S-transferases and related uncharacterized proteins; Region: GST_C_YghU_like; cd10292 983545010680 dimer interface [polypeptide binding]; other site 983545010681 N-terminal domain interface [polypeptide binding]; other site 983545010682 active site 983545010683 SapC; Region: SapC; pfam07277 983545010684 Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578 983545010685 Sodium:solute symporter family; Region: SSF; cl00456 983545010686 putative transporter; Provisional; Region: PRK10484 983545010687 SapC; Region: SapC; pfam07277 983545010688 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 983545010689 Dehydrogenases (flavoproteins) [Energy production and conversion]; Region: FixC; COG0644 983545010690 TonB-dependent receptor; Region: TonB-Xanth-Caul; TIGR01782 983545010691 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl00284 983545010692 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl00284 983545010693 Alpha-galactosidase [Carbohydrate transport and metabolism]; Region: GalA; COG3345 983545010694 The enzymes of glycosyl hydrolase family 31 (GH31) occur in prokaryotes, eukaryotes, and archaea with a wide range of hydrolytic activities, including alpha-glucosidase (glucoamylase and sucrase-isomaltase), alpha-xylosidase, 6-alpha-glucosyltransferase; Region: GH31; cl11402 983545010695 renal dipeptidase (rDP), best studied in mammals and also called membrane or microsomal dipeptidase, is a membrane-bound glycoprotein hydrolyzing dipeptides and is involved in hydrolytic metabolism of penem and carbapenem beta-lactam antibiotics; Region: rDP_like; cd01301 983545010696 active site 983545010697 dimer interface [polypeptide binding]; other site 983545010698 Platelet-activating factor acetylhydrolase, isoform II; Region: PAF-AH_p_II; pfam03403 983545010699 Predicted dienelactone hydrolase [General function prediction only]; Region: COG4188 983545010700 Predicted proline hydroxylase [Posttranslational modification, protein turnover, chaperones]; Region: EGL-9; COG3751 983545010701 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy; cl15773 983545010702 DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012 983545010703 active site 983545010704 catalytic site [active] 983545010705 substrate binding site [chemical binding]; other site 983545010706 SAM-dependent 16S ribosomal RNA C1402 ribose 2'-O-methyltransferase; Provisional; Region: PRK14994 983545010707 Precorrin-3B methylase [Coenzyme metabolism]; Region: CobJ; cl00304 983545010708 Putative lipoprotein [General function prediction only]; Region: LppC; COG3107 983545010709 Periplasmic binding component of lipoprotein LppC, an immunodominant antigen; Region: PBP1_YraM_LppC_lipoprotein_like; cd06339 983545010710 putative ligand binding site [chemical binding]; other site 983545010711 Restriction endonuclease; Region: Mrr_cat; cl00516 983545010712 Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006 983545010713 dimer interface [polypeptide binding]; other site 983545010714 active site 983545010715 BON domain; Region: BON; cl02771 983545010716 BON domain; Region: BON; cl02771 983545010717 Stringent starvation protein B; Region: SspB; cl01120 983545010718 stringent starvation protein A; Provisional; Region: sspA; PRK09481 983545010719 GST_N family, Stringent starvation protein A (SspA) subfamily; SspA is a RNA polymerase (RNAP)-associated protein required for the lytic development of phage P1 and for stationary phase-induced acid tolerance of E. coli. It is implicated in survival...; Region: GST_N_SspA; cd03059 983545010720 C-terminal domain interface [polypeptide binding]; other site 983545010721 putative GSH binding site (G-site) [chemical binding]; other site 983545010722 dimer interface [polypeptide binding]; other site 983545010723 C-terminal, alpha helical domain of Stringent starvation protein A; Region: GST_C_SspA; cd03186 983545010724 dimer interface [polypeptide binding]; other site 983545010725 N-terminal domain interface [polypeptide binding]; other site 983545010726 Cytochrome C1 family; Region: Cytochrom_C1; pfam02167 983545010727 cytochrome b; Provisional; Region: CYTB; MTH00145 983545010728 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cd00284 983545010729 Qi binding site; other site 983545010730 intrachain domain interface; other site 983545010731 interchain domain interface [polypeptide binding]; other site 983545010732 heme bH binding site [chemical binding]; other site 983545010733 heme bL binding site [chemical binding]; other site 983545010734 Qo binding site; other site 983545010735 Cytochrome b(C-terminus)/b6/petD: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: cytochrome_b_C; cd00290 983545010736 interchain domain interface [polypeptide binding]; other site 983545010737 intrachain domain interface; other site 983545010738 Qi binding site; other site 983545010739 Qo binding site; other site 983545010740 Ubiquitinol-cytochrome C reductase Fe-S subunit TAT signal; Region: UCR_Fe-S_N; pfam10399 983545010741 ubiquinol-cytochrome c reductase, iron-sulfur subunit; Region: Rieske_proteo; TIGR01416 983545010742 Iron-sulfur protein (ISP) component of the bc(1) complex family, Rieske domain; The Rieske domain is a [2Fe-2S] cluster binding domain involved in electron transfer. The bc(1) complex is a multisubunit enzyme found in many different organisms including...; Region: Rieske_cytochrome_bc1; cd03470 983545010743 [2Fe-2S] cluster binding site [ion binding]; other site 983545010744 Ribosomal protein S9/S16; Region: Ribosomal_S9; cl00334 983545010745 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 983545010746 23S rRNA interface [nucleotide binding]; other site 983545010747 L3 interface [polypeptide binding]; other site 983545010748 FOG: CBS domain [General function prediction only]; Region: COG0517 983545010749 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_27; cd04640 983545010750 nucleoside triphosphate pyrophosphohydrolase; Reviewed; Region: mazG; PRK09562 983545010751 MazG nucleotide pyrophosphohydrolase domain; Region: MazG; cl00345 983545010752 The Death Domain Superfamily of protein-protein interaction domains; Region: DD_superfamily; cl14633 983545010753 MazG nucleotide pyrophosphohydrolase domain; Region: MazG; cl00345 983545010754 (p)ppGpp synthetase I/GTP pyrophosphokinase; Provisional; Region: relA; PRK10872 983545010755 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 983545010756 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 983545010757 synthetase active site [active] 983545010758 NTP binding site [chemical binding]; other site 983545010759 metal binding site [ion binding]; metal-binding site 983545010760 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 983545010761 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 983545010762 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; cl00500 983545010763 Pyridoxine 5'-phosphate (PNP) synthase domain; pyridoxal 5'-phosphate is the active form of vitamin B6 that acts as an essential, ubiquitous coenzyme in amino acid metabolism. In bacteria, formation of pyridoxine 5'-phosphate is a step in the...; Region: PNPsynthase; cd00003 983545010764 active site 983545010765 hydrophilic channel; other site 983545010766 dimerization interface [polypeptide binding]; other site 983545010767 catalytic residues [active] 983545010768 active site lid [active] 983545010769 DNA repair protein RecO; Reviewed; Region: recO; PRK00085 983545010770 Recombination protein O N terminal; Region: RecO_N; cl15812 983545010771 Recombination protein O C terminal; Region: RecO_C; pfam02565 983545010772 ssDNA exonuclease RecJ; Provisional; Region: PRK11070 983545010773 DHH family; Region: DHH; pfam01368 983545010774 DHHA1 domain; Region: DHHA1; pfam02272 983545010775 protein disulfide isomerase II DsbC; Provisional; Region: PRK10877 983545010776 DsbA family, DsbC and DsbG subfamily; V-shaped homodimeric proteins containing a redox active CXXC motif imbedded in a TRX fold. They function as protein disulfide isomerases and chaperones in the bacterial periplasm to correct non-native disulfide bonds...; Region: DsbA_DsbC_DsbG; cd03020 983545010777 dimerization domain [polypeptide binding]; other site 983545010778 dimer interface [polypeptide binding]; other site 983545010779 catalytic residues [active] 983545010780 site-specific tyrosine recombinase XerD; Reviewed; Region: xerD; PRK00283 983545010781 XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798 983545010782 Int/Topo IB signature motif; other site 983545010783 active site 983545010784 Domain of unknown function (DUF2007); Region: DUF2007; pfam09413 983545010785 Tfp pilus assembly protein, ATPase PilU [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilU; COG5008 983545010786 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 983545010787 Walker A motif; other site 983545010788 ATP binding site [chemical binding]; other site 983545010789 Walker B motif; other site 983545010790 Tfp pilus assembly protein, pilus retraction ATPase PilT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilT; COG2805 983545010791 Pilus retraction ATPase PilT. PilT is a nucleotide binding protein responsible for the retraction of type IV pili, likely by pili disassembly. This retraction provides the force required for travel of bacteria in low water environments by a mechanism...; Region: PilT; cd01131 983545010792 Walker A motif; other site 983545010793 ATP binding site [chemical binding]; other site 983545010794 Walker B motif; other site 983545010795 Pyridoxal 5-phosphate (PLP)-binding TIM barrel domain of Type III PLP-Dependent Enzymes, Yggs-like proteins; Region: PLPDE_III_Yggs_like; cd06824 983545010796 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 983545010797 catalytic residue [active] 983545010798 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880 983545010799 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 983545010800 YGGT family; Region: YGGT; cl00508 983545010801 YGGT family; Region: YGGT; cl00508 983545010802 Domain of unknown function (DUF4426); Region: DUF4426; pfam14467 983545010803 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 983545010804 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 983545010805 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 983545010806 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 983545010807 dimer interface [polypeptide binding]; other site 983545010808 phosphorylation site [posttranslational modification] 983545010809 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 983545010810 ATP binding site [chemical binding]; other site 983545010811 Mg2+ binding site [ion binding]; other site 983545010812 G-X-G motif; other site 983545010813 Response regulator receiver domain; Region: Response_reg; pfam00072 983545010814 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 983545010815 active site 983545010816 phosphorylation site [posttranslational modification] 983545010817 intermolecular recognition site; other site 983545010818 dimerization interface [polypeptide binding]; other site 983545010819 Ligand-binding domain of DNA transcription repressor specific for xylose (XylR); Region: PBP1_XylR; cd01543 983545010820 putative dimerization interface [polypeptide binding]; other site 983545010821 putative ligand binding site [chemical binding]; other site 983545010822 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 983545010823 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 983545010824 D-xylulose kinases, Escherichia coli xylulokinase-like subgroup; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_D-XK_EcXK-like; cd07808 983545010825 xylulokinase; Provisional; Region: PRK15027 983545010826 N- and C-terminal domain interface [polypeptide binding]; other site 983545010827 active site 983545010828 catalytic site [active] 983545010829 metal binding site [ion binding]; metal-binding site 983545010830 xylulose binding site [chemical binding]; other site 983545010831 putative ATP binding site [chemical binding]; other site 983545010832 homodimer interface [polypeptide binding]; other site 983545010833 L-rhamnose isomerase (RhaA); Region: RhaA; cl09945 983545010834 D-xylose transporter XylE; Provisional; Region: xylE; PRK10077 983545010835 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 983545010836 putative substrate translocation pore; other site 983545010837 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 983545010838 Glycosyl hydrolase family 43, includes arabinoxylan arabinofuranohydrolase, beta-xylosidase, endo-1,4-beta-xylanase, alpha-L-arabinofuranosidase; Region: GH43_AXH_like; cd08990 983545010839 substrate binding site [chemical binding]; other site 983545010840 active site 983545010841 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 983545010842 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 983545010843 beta-D-glucoside glucohydrolase; Provisional; Region: PRK15098 983545010844 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971 983545010845 Glycosyl hydrolase family 3 C-terminal domain; Region: Glyco_hydro_3_C; pfam01915 983545010846 Fibronectin type III-like domain; Region: Fn3-like; cl15273 983545010847 Transcriptional regulators [Transcription]; Region: PurR; COG1609 983545010848 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 983545010849 DNA binding site [nucleotide binding] 983545010850 domain linker motif; other site 983545010851 Ligand binding domain of DNA transcription iso-repressor GalS, which is one of two regulatory proteins involved in galactose transport and metabolism; Region: PBP1_GalS_like; cd06270 983545010852 dimerization interface (closed form) [polypeptide binding]; other site 983545010853 ligand binding site [chemical binding]; other site 983545010854 melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392 983545010855 putative symporter YagG; Provisional; Region: PRK09669 983545010856 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 983545010857 Fucose permease [Carbohydrate transport and metabolism]; Region: FucP; COG0738 983545010858 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 983545010859 putative substrate translocation pore; other site 983545010860 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 983545010861 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971 983545010862 Glycosyl hydrolase family 3 C-terminal domain; Region: Glyco_hydro_3_C; pfam01915 983545010863 TonB-dependent receptor; Region: TonB-Xanth-Caul; TIGR01782 983545010864 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl00284 983545010865 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl00284 983545010866 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl00284 983545010867 SapC; Region: SapC; pfam07277 983545010868 JmjC domain, hydroxylase; Region: JmjC; cl15814 983545010869 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 983545010870 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 983545010871 putative catalytic site [active] 983545010872 putative metal binding site [ion binding]; other site 983545010873 putative phosphate binding site [ion binding]; other site 983545010874 Catalytic domain, repeat 1, of uncharacterized bacterial proteins with similarity to vertebrate phospholipases, PLD1 and PLD2; Region: PLDc_vPLD1_2_like_bac_1; cd09140 983545010875 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 983545010876 putative active site [active] 983545010877 putative active site [active] 983545010878 catalytic site [active] 983545010879 catalytic site [active] 983545010880 Catalytic domain, repeat 2, of uncharacterized bacterial proteins with similarity to vertebrate phospholipases, PLD1 and PLD2; Region: PLDc_vPLD1_2_like_bac_2; cd09143 983545010881 phospholipase D; Region: PLN02866 983545010882 putative active site [active] 983545010883 catalytic site [active] 983545010884 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 983545010885 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box protein; Region: CSP_CDS; cd04458 983545010886 DNA-binding site [nucleotide binding]; DNA binding site 983545010887 RNA-binding motif; other site 983545010888 Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014 983545010889 dimer interface [polypeptide binding]; other site 983545010890 catalytic triad [active] 983545010891 peroxidatic and resolving cysteines [active] 983545010892 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 983545010893 NADP+ binding site [chemical binding]; other site 983545010894 folate binding site [chemical binding]; other site 983545010895 GTPase CgtA; Reviewed; Region: obgE; PRK12298 983545010896 GTP1/OBG; Region: GTP1_OBG; pfam01018 983545010897 Obg GTPase; Region: Obg; cd01898 983545010898 G1 box; other site 983545010899 GTP/Mg2+ binding site [chemical binding]; other site 983545010900 Switch I region; other site 983545010901 G2 box; other site 983545010902 G3 box; other site 983545010903 Switch II region; other site 983545010904 G4 box; other site 983545010905 G5 box; other site 983545010906 Ribosomal L27 protein; Region: Ribosomal_L27; cl00359 983545010907 Ribosomal prokaryotic L21 protein; Region: Ribosomal_L21p; cl00382 983545010908 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 983545010909 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 983545010910 substrate binding pocket [chemical binding]; other site 983545010911 chain length determination region; other site 983545010912 substrate-Mg2+ binding site; other site 983545010913 catalytic residues [active] 983545010914 aspartate-rich region 1; other site 983545010915 active site lid residues [active] 983545010916 aspartate-rich region 2; other site 983545010917 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl00284 983545010918 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl00284 983545010919 Uncharacterized conserved protein [Function unknown]; Region: COG3595 983545010920 Domain of unknown function (DUF4098); Region: DUF4098; pfam13345 983545010921 Domain of unknown function (DUF4098); Region: DUF4098; pfam13345 983545010922 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 983545010923 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 983545010924 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 983545010925 DNA binding residues [nucleotide binding] 983545010926 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2258 983545010927 MOSC domain; Region: MOSC; pfam03473 983545010928 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 983545010929 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 983545010930 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 983545010931 Ribosomal protein S18; Region: Ribosomal_S18; cl00373 983545010932 Ribosomal protein S6; Region: Ribosomal_S6; cl00414 983545010933 aerobic respiration control sensor protein ArcB; Provisional; Region: PRK11091 983545010934 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 983545010935 putative active site [active] 983545010936 heme pocket [chemical binding]; other site 983545010937 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 983545010938 dimer interface [polypeptide binding]; other site 983545010939 phosphorylation site [posttranslational modification] 983545010940 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 983545010941 ATP binding site [chemical binding]; other site 983545010942 Mg2+ binding site [ion binding]; other site 983545010943 G-X-G motif; other site 983545010944 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 983545010945 active site 983545010946 phosphorylation site [posttranslational modification] 983545010947 intermolecular recognition site; other site 983545010948 dimerization interface [polypeptide binding]; other site 983545010949 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cl00086 983545010950 glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750 983545010951 Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713 983545010952 active site 983545010953 dimer interface [polypeptide binding]; other site 983545010954 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 983545010955 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 983545010956 active site 983545010957 FMN binding site [chemical binding]; other site 983545010958 substrate binding site [chemical binding]; other site 983545010959 3Fe-4S cluster binding site [ion binding]; other site 983545010960 gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982 983545010961 domain interface; other site 983545010962 glutamate synthase small subunit family protein, proteobacterial; Region: gltD_gamma_fam; TIGR01318 983545010963 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 983545010964 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 983545010965 Iron-containing alcohol dehydrogenases-like; Region: Fe-ADH6; cd08194 983545010966 putative active site [active] 983545010967 metal binding site [ion binding]; metal-binding site 983545010968 Predicted dithiol-disulfide isomerase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FrnE; COG2761 983545010969 DsbA family, FrnE subfamily; FrnE is a DsbA-like protein containing a CXXC motif. It is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the aromatic antibiotics frenolicin and nanaomycins; Region: DsbA_FrnE; cd03024 983545010970 catalytic residues [active] 983545010971 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 983545010972 oligomerisation interface [polypeptide binding]; other site 983545010973 mobile loop; other site 983545010974 roof hairpin; other site 983545010975 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 983545010976 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 983545010977 ring oligomerisation interface [polypeptide binding]; other site 983545010978 ATP/Mg binding site [chemical binding]; other site 983545010979 stacking interactions; other site 983545010980 hinge regions; other site 983545010981 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 983545010982 multiple promoter invertase; Provisional; Region: mpi; PRK13413 983545010983 catalytic residues [active] 983545010984 catalytic nucleophile [active] 983545010985 Presynaptic Site I dimer interface [polypeptide binding]; other site 983545010986 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 983545010987 Synaptic Flat tetramer interface [polypeptide binding]; other site 983545010988 Synaptic Site I dimer interface [polypeptide binding]; other site 983545010989 DNA binding site [nucleotide binding] 983545010990 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 983545010991 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 983545010992 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 983545010993 DNA binding site [nucleotide binding] 983545010994 Int/Topo IB signature motif; other site 983545010995 active site 983545010996 Ribbon-helix-helix protein, copG family; Region: RHH_1; cl15783 983545010997 Plasmid stabilisation system protein; Region: Plasmid_stabil; cl11422 983545010998 7TM diverse intracellular signalling; Region: 7TMR-DISM_7TM; pfam07695 983545010999 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 983545011000 metal binding site [ion binding]; metal-binding site 983545011001 active site 983545011002 I-site; other site 983545011003 This family of ATP-binding proteins belongs to a multisubunit transporter involved in drug resistance (BcrA and DrrA), nodulation, lipid transport, and lantibiotic immunity. In bacteria and archaea, these transporters usually include an ATP-binding...; Region: ABC_DR_subfamily_A; cd03230 983545011004 gallidermin-class lantibiotic protection ABC transporter, ATP-binding subunit; Region: galliderm_ABC; TIGR03740 983545011005 Walker A/P-loop; other site 983545011006 ATP binding site [chemical binding]; other site 983545011007 Q-loop/lid; other site 983545011008 ABC transporter signature motif; other site 983545011009 Walker B; other site 983545011010 D-loop; other site 983545011011 H-loop/switch region; other site 983545011012 ABC-2 type transporter; Region: ABC2_membrane; cl11417 983545011013 Domain of unknown function (DUF3526); Region: DUF3526; pfam12040 983545011014 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 983545011015 Domain of unknown function (DUF3526); Region: DUF3526; pfam12040 983545011016 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 983545011017 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 983545011018 N-terminal plug; other site 983545011019 ligand-binding site [chemical binding]; other site 983545011020 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 983545011021 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 983545011022 A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cl00279 983545011023 active site 983545011024 ferrichrome receptor precursor protein; Provisional; Region: PRK14050 983545011025 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 983545011026 N-terminal plug; other site 983545011027 ligand-binding site [chemical binding]; other site 983545011028 Late embryogenesis abundant protein; Region: LEA_2; cl12118 983545011029 Cytochrome b562; Region: Cytochrom_B562; cl01546 983545011030 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl15306 983545011031 membrane-bound complex binding site; other site 983545011032 hinge residues; other site 983545011033 deoxyguanosinetriphosphate triphosphohydrolase; Provisional; Region: dgt; PRK04926 983545011034 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 983545011035 Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286 983545011036 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl00284 983545011037 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl00284 983545011038 putative PEP-CTERM system TPR-repeat lipoprotein; Region: PEP_TPR_lipo; TIGR02917 983545011039 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 983545011040 binding surface 983545011041 TPR motif; other site 983545011042 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 983545011043 binding surface 983545011044 TPR motif; other site 983545011045 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 983545011046 binding surface 983545011047 TPR motif; other site 983545011048 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 983545011049 TPR motif; other site 983545011050 binding surface 983545011051 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 983545011052 binding surface 983545011053 TPR motif; other site 983545011054 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 983545011055 TPR motif; other site 983545011056 binding surface 983545011057 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 983545011058 TPR motif; other site 983545011059 binding surface 983545011060 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 983545011061 binding surface 983545011062 TPR motif; other site 983545011063 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 983545011064 binding surface 983545011065 TPR motif; other site 983545011066 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 983545011067 The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915 983545011068 Protein export membrane protein; Region: SecD_SecF; cl14618 983545011069 multidrug efflux system transporter AcrA; Provisional; Region: PRK15030 983545011070 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 983545011071 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 983545011072 Phospholipid methyltransferase; Region: PEMT; cl00763 983545011073 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 983545011074 FAD dependent oxidoreductase; Region: DAO; pfam01266 983545011075 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 983545011076 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 983545011077 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 983545011078 AMP-binding enzyme; Region: AMP-binding; cl15778 983545011079 enoyl-CoA hydratase; Provisional; Region: PRK06688 983545011080 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 983545011081 substrate binding site [chemical binding]; other site 983545011082 oxyanion hole (OAH) forming residues; other site 983545011083 trimer interface [polypeptide binding]; other site 983545011084 Helix-turn-helix domains; Region: HTH; cl00088 983545011085 5-oxoprolinase; Region: PLN02666 983545011086 Hydantoinase/oxoprolinase N-terminal region; Region: Hydant_A_N; pfam05378 983545011087 Hydantoinase/oxoprolinase; Region: Hydantoinase_A; cl00668 983545011088 manganese transport protein MntH; Reviewed; Region: PRK00701; cl15845 983545011089 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 983545011090 Protein of unknown function (DUF3010); Region: DUF3010; pfam11215 983545011091 Fucose permease [Carbohydrate transport and metabolism]; Region: FucP; COG0738 983545011092 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 983545011093 putative substrate translocation pore; other site 983545011094 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 983545011095 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl00284 983545011096 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl00284 983545011097 Alpha amylase catalytic domain found in Amylosucrase; Region: AmyAc_Amylosucrase; cd11324 983545011098 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 983545011099 active site 983545011100 catalytic site [active] 983545011101 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; cl02706 983545011102 Transcriptional regulators [Transcription]; Region: PurR; COG1609 983545011103 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 983545011104 DNA binding site [nucleotide binding] 983545011105 domain linker motif; other site 983545011106 Ligand-binding domain of uncharacterized DNA-binding regulatory proteins that are members of the LacI-GalR family of bacterial transcription repressors; Region: PBP1_LacI_like_3; cd06279 983545011107 putative ligand binding site [chemical binding]; other site 983545011108 putative dimerization interface [polypeptide binding]; other site 983545011109 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 983545011110 Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic...; Region: GST_N_family; cd00570 983545011111 C-terminal domain interface [polypeptide binding]; other site 983545011112 GSH binding site (G-site) [chemical binding]; other site 983545011113 dimer interface [polypeptide binding]; other site 983545011114 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776 983545011115 N-terminal domain interface [polypeptide binding]; other site 983545011116 dimer interface [polypeptide binding]; other site 983545011117 substrate binding pocket (H-site) [chemical binding]; other site 983545011118 NYN ribonuclease and ATPase of PhoH family domains [General function prediction only]; Region: COG1875 983545011119 PIN domain of bacterial Smg6-like homologs with PhoH-like ATPase domains; Region: PIN_PhoHL-ATPase; cd09883 983545011120 putative active site [active] 983545011121 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 983545011122 ATP-dependent helicase HepA; Validated; Region: PRK04914 983545011123 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 983545011124 ATP binding site [chemical binding]; other site 983545011125 putative Mg++ binding site [ion binding]; other site 983545011126 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 983545011127 nucleotide binding region [chemical binding]; other site 983545011128 ATP-binding site [chemical binding]; other site 983545011129 PseudoU_synth_RsuA/RluD: Pseudouridine synthase, RsuA/RluD family. This group is comprised of eukaryotic, bacterial and archeal proteins similar to eight site specific Escherichia coli pseudouridine synthases: RsuA, RluA, RluB, RluC, RluD, RluE, RluF and...; Region: PseudoU_synth_RluCD_like; cd02869 983545011130 active site 983545011131 Protein of unknown function (DUF3530); Region: DUF3530; pfam12048 983545011132 muropeptide transporter; Validated; Region: ampG; PRK11010 983545011133 AmpG-related permease; Region: 2A0125; TIGR00901 983545011134 PAS fold; Region: PAS_4; pfam08448 983545011135 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 983545011136 metal binding site [ion binding]; metal-binding site 983545011137 active site 983545011138 I-site; other site 983545011139 Response regulator receiver domain; Region: Response_reg; pfam00072 983545011140 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 983545011141 active site 983545011142 phosphorylation site [posttranslational modification] 983545011143 intermolecular recognition site; other site 983545011144 dimerization interface [polypeptide binding]; other site 983545011145 Chemotaxis protein CheC, inhibitor of MCP methylation [Cell motility and secretion / Signal transduction mechanisms]; Region: CheC; COG1776 983545011146 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 983545011147 dimerization interface [polypeptide binding]; other site 983545011148 active site 983545011149 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; cl01155 983545011150 CAAX protease self-immunity; Region: Abi; cl00558 983545011151 Ferritin-like domain; Region: Ferritin; pfam00210 983545011152 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 983545011153 dimerization interface [polypeptide binding]; other site 983545011154 DPS ferroxidase diiron center [ion binding]; other site 983545011155 ion pore; other site 983545011156 gluconate 5-dehydrogenase; Provisional; Region: PRK08213 983545011157 RhlG and related beta-ketoacyl reductases, classical (c) SDRs; Region: RhlG_SDR_c; cd08942 983545011158 NADP binding site [chemical binding]; other site 983545011159 active site 983545011160 Prolipoprotein diacylglyceryl transferase; Region: LGT; cl00478 983545011161 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 983545011162 fused phosphoenolpyruvate-protein phosphotransferase PtsP/GAF domain; Provisional; Region: PRK11061 983545011163 GAF domain; Region: GAF; cl15785 983545011164 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 983545011165 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; cl01586 983545011166 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl09155 983545011167 Diadenosine tetraphosphate (Ap4A) hydrolase is a member of the Nudix hydrolase superfamily. Members of this family are well represented in a variety of prokaryotic and eukaryotic organisms. Phylogenetic analysis reveals two distinct subgroups where plant...; Region: Ap4A_hydrolase_plant_like; cd03671 983545011168 putative active site [active] 983545011169 Ap4A binding site [chemical binding]; other site 983545011170 nudix motif; other site 983545011171 putative metal binding site [ion binding]; other site 983545011172 YhhN-like protein; Region: YhhN; cl01505 983545011173 MutH is a 28kD endonuclease involved in methyl-directed DNA mismatch repair in gram negative bacteria. MutH is both sequence-specific and methylation-specific, introducing a nick in the unmethylated strand of a hemi-methylated d(GATC) DNA duplex. MutH...; Region: MutH_Sau3AI; cd00583 983545011174 putative DNA-binding cleft [nucleotide binding]; other site 983545011175 putative DNA clevage site; other site 983545011176 molecular lever; other site 983545011177 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 983545011178 Aldehyde dehydrogenase family 21A1-like; Region: ALDH_F21_RNP123; cd07147 983545011179 NAD(P) binding site [chemical binding]; other site 983545011180 catalytic residues [active] 983545011181 acetolactate synthase; Reviewed; Region: PRK08322 983545011182 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 983545011183 PYR/PP interface [polypeptide binding]; other site 983545011184 dimer interface [polypeptide binding]; other site 983545011185 TPP binding site [chemical binding]; other site 983545011186 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; cl00815 983545011187 Thiamine pyrophosphate (TPP) family, Acetolactate synthase (ALS) subfamily, TPP-binding module; composed of proteins similar to Klebsiella pneumoniae ALS, a catabolic enzyme required for butanediol fermentation. ALS catalyzes the conversion of 2...; Region: TPP_ALS; cd02010 983545011188 TPP-binding site [chemical binding]; other site 983545011189 dimer interface [polypeptide binding]; other site 983545011190 Uncharacterized subgroup of the CYTH-like superfamily having an associated CHAD domain; Region: CYTH-like_Pase_CHAD; cd07756 983545011191 putative active site [active] 983545011192 putative metal binding residues [ion binding]; other site 983545011193 signature motif; other site 983545011194 putative triphosphate binding site [ion binding]; other site 983545011195 SH3 domain-containing protein; Provisional; Region: PRK10884 983545011196 Bacterial SH3 domain; Region: SH3_3; cl02551 983545011197 LysE type translocator; Region: LysE; cl00565 983545011198 Uncharacterized protein conserved in bacteria (DUF2062); Region: DUF2062; cl01261 983545011199 TIGR03545 family protein; Region: TIGR03545 983545011200 Septum formation initiator; Region: DivIC; cl11433 983545011201 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 983545011202 substrate binding site; other site 983545011203 dimer interface; other site 983545011204 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554 983545011205 homotrimer interaction site [polypeptide binding]; other site 983545011206 zinc binding site [ion binding]; other site 983545011207 CDP-binding sites; other site 983545011208 tRNA pseudouridine synthase D (TruD); Region: TruD; pfam01142 983545011209 PseudoU_synth_EcTruD: Pseudouridine synthase, TruD family. This group consists of bacterial pseudouridine synthases similar to Escherichia coli TruD. Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to...; Region: PseudoU_synth_EcTruD; cd02575 983545011210 Permutation of conserved domain; other site 983545011211 active site 983545011212 PseudoU_synth: Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi). Pseudouridine synthases contains the RsuA/RluD, TruA, TruB and TruD families. This group consists of...; Region: PseudoU_synth; cl00130 983545011213 Survival protein SurE; Region: SurE; cl00448 983545011214 Protein-L-isoaspartate carboxylmethyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: Pcm; COG2518 983545011215 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 983545011216 S-adenosylmethionine binding site [chemical binding]; other site 983545011217 Domain of unknown function (DUF368); Region: DUF368; cl00893 983545011218 lipoprotein NlpD; Provisional; Region: nlpD; PRK10871 983545011219 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118 983545011220 putative peptidoglycan binding site; other site 983545011221 RNA polymerase sigma factor RpoS; Region: rpoS_proteo; TIGR02394 983545011222 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 983545011223 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 983545011224 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 983545011225 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 983545011226 DNA binding residues [nucleotide binding] 983545011227 Protein of unknown function (DUF3718); Region: DUF3718; pfam12514 983545011228 SWIM/SEC-C metal-binding motif protein, PBPRA1643 family; Region: SWIM_PBPRA1643; TIGR04102 983545011229 putative hydrolase; Validated; Region: PRK09248 983545011230 RNase P subunit p30; Region: RNase_P_p30; cl03389 983545011231 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 983545011232 nucleoside/Zn binding site; other site 983545011233 dimer interface [polypeptide binding]; other site 983545011234 catalytic motif [active] 983545011235 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 983545011236 non-specific DNA binding site [nucleotide binding]; other site 983545011237 salt bridge; other site 983545011238 sequence-specific DNA binding site [nucleotide binding]; other site 983545011239 Predicted amidohydrolase [General function prediction only]; Region: COG0388 983545011240 Uncharacterized subgroup of the nitrilase superfamily; some members of this subgroup have an N-terminal RimI domain (class 12 nitrilases); Region: nitrilase_Rim1_like; cd07574 983545011241 putative active site [active] 983545011242 catalytic triad [active] 983545011243 putative dimer interface [polypeptide binding]; other site 983545011244 arginine decarboxylase; Provisional; Region: PRK05354 983545011245 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Arginine Decarboxylase; Region: PLPDE_III_ADC; cd06830 983545011246 dimer interface [polypeptide binding]; other site 983545011247 active site 983545011248 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 983545011249 catalytic residues [active] 983545011250 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 983545011251 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 983545011252 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Ada; COG2169 983545011253 Metal binding domain of Ada; Region: Ada_Zn_binding; pfam02805 983545011254 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 983545011255 AlkA N-terminal domain; Region: AlkA_N; cl05528 983545011256 3-methyl-adenine DNA glycosylase II; Provisional; Region: PRK10308 983545011257 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786 983545011258 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870 983545011259 methylated-DNA--protein-cysteine methyltransferase; Provisional; Region: PRK00901 983545011260 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 983545011261 DNA binding site [nucleotide binding] 983545011262 active site 983545011263 EamA-like transporter family; Region: EamA; cl01037 983545011264 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 983545011265 EamA-like transporter family; Region: EamA; cl01037 983545011266 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 983545011267 metal binding site [ion binding]; metal-binding site 983545011268 active site 983545011269 I-site; other site 983545011270 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK09451 983545011271 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 983545011272 Substrate binding site; other site 983545011273 Mg++ binding site; other site 983545011274 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 983545011275 active site 983545011276 substrate binding site [chemical binding]; other site 983545011277 CoA binding site [chemical binding]; other site 983545011278 DNA-bindng transcriptional repressor SrlR; Provisional; Region: srlR; PRK10434 983545011279 Helix-turn-helix domains; Region: HTH; cl00088 983545011280 SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339 983545011281 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 983545011282 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 983545011283 glutaminase active site [active] 983545011284 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 983545011285 dimer interface [polypeptide binding]; other site 983545011286 active site 983545011287 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 983545011288 dimer interface [polypeptide binding]; other site 983545011289 active site 983545011290 HsdM N-terminal domain; Region: HsdM_N; pfam12161 983545011291 N-6 DNA Methylase; Region: N6_Mtase; pfam02384 983545011292 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 983545011293 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 983545011294 Fic/DOC family; Region: Fic; cl00960 983545011295 Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: COG0610 983545011296 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; cl14958 983545011297 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 983545011298 ATP binding site [chemical binding]; other site 983545011299 putative Mg++ binding site [ion binding]; other site 983545011300 Domain of unknown function (DUF3387); Region: DUF3387; pfam11867 983545011301 Helix-turn-helix domains; Region: HTH; cl00088 983545011302 TnsA endonuclease N terminal; Region: Tn7_Tnp_TnsA_N; cl07370 983545011303 TnsA endonuclease C terminal; Region: Tn7_Tnp_TnsA_C; pfam08721 983545011304 Integrase core domain; Region: rve; cl01316 983545011305 Mu transposase, C-terminal; Region: Mu-transpos_C; pfam09299 983545011306 AAA domain; Region: AAA_22; pfam13401 983545011307 Class III nucleotidyl cyclases; Region: Nucleotidyl_cyc_III; cl11967 983545011308 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 983545011309 non-specific DNA binding site [nucleotide binding]; other site 983545011310 salt bridge; other site 983545011311 sequence-specific DNA binding site [nucleotide binding]; other site 983545011312 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 983545011313 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 983545011314 N-terminal plug; other site 983545011315 ligand-binding site [chemical binding]; other site 983545011316 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 983545011317 classical (c) SDRs; Region: SDR_c; cd05233 983545011318 NAD(P) binding site [chemical binding]; other site 983545011319 active site 983545011320 hypothetical protein; Provisional; Region: PRK06194 983545011321 classical (c) SDRs; Region: SDR_c; cd05233 983545011322 NAD(P) binding site [chemical binding]; other site 983545011323 active site 983545011324 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 983545011325 Helix-turn-helix domains; Region: HTH; cl00088 983545011326 enoyl-CoA hydratase; Provisional; Region: PRK08140 983545011327 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 983545011328 substrate binding site [chemical binding]; other site 983545011329 oxyanion hole (OAH) forming residues; other site 983545011330 trimer interface [polypeptide binding]; other site 983545011331 aldehyde dehydrogenase; Provisional; Region: PRK11903 983545011332 N-terminal domain of the monoamine oxidase C dehydratase; Region: ALDH_MaoC-N; cd07128 983545011333 substrate binding site [chemical binding]; other site 983545011334 dimer interface [polypeptide binding]; other site 983545011335 NADP binding site [chemical binding]; other site 983545011336 catalytic residues [active] 983545011337 SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450 983545011338 Strictosidine synthase; Region: Str_synth; pfam03088 983545011339 enoyl-CoA hydratase; Provisional; Region: PRK06494 983545011340 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 983545011341 substrate binding site [chemical binding]; other site 983545011342 oxyanion hole (OAH) forming residues; other site 983545011343 trimer interface [polypeptide binding]; other site 983545011344 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cl15762 983545011345 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 983545011346 CoA-transferase family III; Region: CoA_transf_3; pfam02515 983545011347 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 983545011348 Helix-turn-helix domains; Region: HTH; cl00088 983545011349 The ligand binding domain of nuclear receptors, a family of ligand-activated transcription regulators; Region: NR_LBD; cl11397 983545011350 ligand binding site [chemical binding]; other site 983545011351 coregulator recognition site; other site 983545011352 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 983545011353 D-galactonate transporter; Region: 2A0114; TIGR00893 983545011354 putative substrate translocation pore; other site 983545011355 acyl-CoA synthetase; Provisional; Region: PRK12582 983545011356 AMP-binding enzyme; Region: AMP-binding; cl15778 983545011357 (R)-hydratase [(R)-specific enoyl-CoA hydratase]. Catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. The structure of the monomer includes a five-strand antiparallel...; Region: R_hydratase_like; cd03441 983545011358 active site 983545011359 catalytic site [active] 983545011360 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 983545011361 active site 2 [active] 983545011362 active site 1 [active] 983545011363 pimeloyl-CoA dehydrogenase, small subunit; Region: pimD_small; TIGR03203 983545011364 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 983545011365 active site 983545011366 pimeloyl-CoA dehydrogenase, large subunit; Region: pimC_large; TIGR03204 983545011367 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 983545011368 active site 983545011369 acetyl-CoA acetyltransferase; Provisional; Region: PRK08131 983545011370 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 983545011371 dimer interface [polypeptide binding]; other site 983545011372 active site 983545011373 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 983545011374 multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadJ; PRK11154 983545011375 substrate binding site [chemical binding]; other site 983545011376 oxyanion hole (OAH) forming residues; other site 983545011377 trimer interface [polypeptide binding]; other site 983545011378 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 983545011379 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 983545011380 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 983545011381 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 983545011382 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 983545011383 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506 983545011384 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 983545011385 PaaX-like protein C-terminal domain; Region: PaaX_C; pfam08223 983545011386 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 983545011387 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 983545011388 active site 983545011389 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 983545011390 metal binding site [ion binding]; metal-binding site 983545011391 active site 983545011392 I-site; other site 983545011393 Protein of unknown function (DUF445); Region: DUF445; pfam04286 983545011394 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 983545011395 dimer interface [polypeptide binding]; other site 983545011396 phosphorylation site [posttranslational modification] 983545011397 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 983545011398 ATP binding site [chemical binding]; other site 983545011399 Mg2+ binding site [ion binding]; other site 983545011400 G-X-G motif; other site 983545011401 Response regulator receiver domain; Region: Response_reg; pfam00072 983545011402 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 983545011403 active site 983545011404 phosphorylation site [posttranslational modification] 983545011405 intermolecular recognition site; other site 983545011406 dimerization interface [polypeptide binding]; other site 983545011407 Response regulator receiver domain; Region: Response_reg; pfam00072 983545011408 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 983545011409 active site 983545011410 phosphorylation site [posttranslational modification] 983545011411 intermolecular recognition site; other site 983545011412 dimerization interface [polypeptide binding]; other site 983545011413 DNA-binding transcriptional regulator MetR; Provisional; Region: PRK15421 983545011414 Helix-turn-helix domains; Region: HTH; cl00088 983545011415 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 983545011416 dimerization interface [polypeptide binding]; other site 983545011417 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 983545011418 Protein of unknown function DUF84; Region: NTPase_I-T; cl00866 983545011419 proteobacterial dedicated sortase system histidine kinase; Region: marine_sort_HK; TIGR03785 983545011420 DOMON-like type 9 carbohydrate binding module at the N-terminus of bacterial sensor histidine kinases; Region: CBM9_like_HisKa; cd09622 983545011421 putative ligand binding site [chemical binding]; other site 983545011422 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 983545011423 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 983545011424 dimer interface [polypeptide binding]; other site 983545011425 phosphorylation site [posttranslational modification] 983545011426 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 983545011427 ATP binding site [chemical binding]; other site 983545011428 Mg2+ binding site [ion binding]; other site 983545011429 G-X-G motif; other site 983545011430 proteobacterial dedicated sortase system response regulator; Region: marine_sort_RR; TIGR03787 983545011431 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 983545011432 active site 983545011433 phosphorylation site [posttranslational modification] 983545011434 intermolecular recognition site; other site 983545011435 dimerization interface [polypeptide binding]; other site 983545011436 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 983545011437 DNA binding site [nucleotide binding] 983545011438 proteobacterial sortase system OmpA family protein; Region: pdsO; TIGR03789 983545011439 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 983545011440 ligand binding site [chemical binding]; other site 983545011441 Vault protein inter-alpha-trypsin domain; Region: VIT; cl02699 983545011442 marine proteobacterial sortase target protein; Region: marine_srt_targ; TIGR03788 983545011443 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 983545011444 metal ion-dependent adhesion site (MIDAS); other site 983545011445 Sortase D (SrtD) is a membrane transpeptidase found in gram-positive bacteria that anchors surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the surface protein substrate is cleaved...; Region: Sortase_D_4; cd05828 983545011446 active site 983545011447 catalytic site [active] 983545011448 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 983545011449 uncharacterized peroxidase-related enzyme; Region: peroxid_rel; TIGR01926 983545011450 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 983545011451 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 983545011452 Walker A/P-loop; other site 983545011453 ATP binding site [chemical binding]; other site 983545011454 Q-loop/lid; other site 983545011455 ABC transporter signature motif; other site 983545011456 Walker B; other site 983545011457 D-loop; other site 983545011458 H-loop/switch region; other site 983545011459 ABC-2 type transporter; Region: ABC2_membrane; cl11417 983545011460 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl15754 983545011461 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 983545011462 Glutamate decarboxylase and related PLP-dependent proteins [Amino acid transport and metabolism]; Region: GadB; COG0076 983545011463 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 983545011464 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 983545011465 catalytic residue [active] 983545011466 pantoate--beta-alanine ligase; Region: panC; TIGR00018 983545011467 Pantoate-beta-alanine ligase; Region: PanC; cd00560 983545011468 active site 983545011469 ATP-binding site [chemical binding]; other site 983545011470 pantoate-binding site; other site 983545011471 HXXH motif; other site 983545011472 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 983545011473 oligomerization interface [polypeptide binding]; other site 983545011474 active site 983545011475 metal binding site [ion binding]; metal-binding site 983545011476 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 983545011477 catalytic center binding site [active] 983545011478 ATP binding site [chemical binding]; other site 983545011479 poly(A) polymerase I; Provisional; Region: pcnB; PRK11623 983545011480 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 983545011481 active site 983545011482 NTP binding site [chemical binding]; other site 983545011483 metal binding triad [ion binding]; metal-binding site 983545011484 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 983545011485 Polymerase A arginine-rich C-terminus; Region: PolyA_pol_arg_C; pfam12626 983545011486 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 983545011487 active site 983545011488 HIGH motif; other site 983545011489 nucleotide binding site [chemical binding]; other site 983545011490 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 983545011491 KMSKS motif; other site 983545011492 Prokaryotic dksA/traR C4-type zinc finger; Region: zf-dskA_traR; cl00755 983545011493 Sugar fermentation stimulation protein; Region: SfsA; cl00647 983545011494 aminopeptidase B; Provisional; Region: PRK05015 983545011495 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 983545011496 interface (dimer of trimers) [polypeptide binding]; other site 983545011497 Substrate-binding/catalytic site; other site 983545011498 Zn-binding sites [ion binding]; other site 983545011499 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 983545011500 MarC family integral membrane protein; Region: MarC; cl00919 983545011501 Protein of unknown function (DUF416); Region: DUF416; cl01166 983545011502 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 983545011503 S-adenosylmethionine binding site [chemical binding]; other site 983545011504 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 983545011505 SRP54-type protein, helical bundle domain; Region: SRP54_N; cl03758 983545011506 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 983545011507 P loop; other site 983545011508 GTP binding site [chemical binding]; other site 983545011509 Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884 983545011510 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 983545011511 Walker A/P-loop; other site 983545011512 ATP binding site [chemical binding]; other site 983545011513 Q-loop/lid; other site 983545011514 ABC transporter signature motif; other site 983545011515 Walker B; other site 983545011516 D-loop; other site 983545011517 H-loop/switch region; other site 983545011518 putative protein insertion permease FtsX; Region: ftsX; TIGR00439 983545011519 FtsX-like permease family; Region: FtsX; cl15850 983545011520 Predicted signal transduction protein containing EAL and modified HD-GYP domains [Signal transduction mechanisms]; Region: COG3434 983545011521 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cl00290 983545011522 RNA polymerase factor sigma-32; Reviewed; Region: PRK06596 983545011523 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 983545011524 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 983545011525 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 983545011526 DNA binding residues [nucleotide binding] 983545011527 acyl-CoA synthetase; Validated; Region: PRK08316 983545011528 AMP-binding enzyme; Region: AMP-binding; cl15778 983545011529 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 983545011530 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 983545011531 NAD(P) binding site [chemical binding]; other site 983545011532 active site 983545011533 Protein of unknown function (DUF1446); Region: DUF1446; pfam07287 983545011534 Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770 983545011535 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 983545011536 ATP-grasp domain; Region: ATP-grasp_4; cl03087 983545011537 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; cl08365 983545011538 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 983545011539 carboxyltransferase (CT) interaction site; other site 983545011540 biotinylation site [posttranslational modification]; other site 983545011541 enoyl-CoA hydratase; Provisional; Region: PRK05995 983545011542 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 983545011543 substrate binding site [chemical binding]; other site 983545011544 oxyanion hole (OAH) forming residues; other site 983545011545 trimer interface [polypeptide binding]; other site 983545011546 3-methylcrotonyl-CoA carboxylase, beta chain; Region: PLN02820 983545011547 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl15772 983545011548 Dioxygenases related to 2-nitropropane dioxygenase [General function prediction only]; Region: COG2070 983545011549 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 983545011550 FMN binding site [chemical binding]; other site 983545011551 substrate binding site [chemical binding]; other site 983545011552 putative catalytic residue [active] 983545011553 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 983545011554 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 983545011555 active site 983545011556 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 983545011557 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_2; cd03138 983545011558 conserved cys residue [active] 983545011559 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 983545011560 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 983545011561 PepSY-associated TM helix; Region: PepSY_TM_2; cl15813 983545011562 Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182 983545011563 PepSY-associated TM helix; Region: PepSY_TM_2; cl15813 983545011564 ferric-rhodotorulic acid outer membrane transporter; Provisional; Region: PRK10003 983545011565 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 983545011566 N-terminal plug; other site 983545011567 ligand-binding site [chemical binding]; other site 983545011568 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 983545011569 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 983545011570 active site 983545011571 HIGH motif; other site 983545011572 dimer interface [polypeptide binding]; other site 983545011573 KMSKS motif; other site 983545011574 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 983545011575 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 983545011576 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 983545011577 ABC-type uncharacterized transport system, permease and ATPase components [General function prediction only]; Region: COG4178 983545011578 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 983545011579 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 983545011580 Walker A/P-loop; other site 983545011581 ATP binding site [chemical binding]; other site 983545011582 Q-loop/lid; other site 983545011583 ABC transporter signature motif; other site 983545011584 Walker B; other site 983545011585 D-loop; other site 983545011586 Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566 983545011587 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 983545011588 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 983545011589 Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538 983545011590 Protein of unknown function (DUF2798); Region: DUF2798; pfam11391 983545011591 Protein of unknown function (DUF2798); Region: DUF2798; pfam11391 983545011592 glutamate dehydrogenase; Provisional; Region: PRK09414 983545011593 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 983545011594 NAD(P) binding domain of glutamate dehydrogenase, subgroup 2; Region: NAD_bind_2_Glu_DH; cd05313 983545011595 NAD(P) binding site [chemical binding]; other site 983545011596 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 983545011597 Sodium:solute symporter family; Region: SSF; cl00456 983545011598 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 983545011599 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 983545011600 bifunctional D-altronate/D-mannonate dehydratase; Provisional; Region: PRK15072 983545011601 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl09108 983545011602 metal binding site [ion binding]; metal-binding site 983545011603 substrate binding pocket [chemical binding]; other site 983545011604 Transcriptional regulators [Transcription]; Region: PurR; COG1609 983545011605 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 983545011606 DNA binding site [nucleotide binding] 983545011607 domain linker motif; other site 983545011608 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 983545011609 dimerization interface [polypeptide binding]; other site 983545011610 ligand binding site [chemical binding]; other site 983545011611 BCCT family transporter; Region: BCCT; cl00569 983545011612 Nucleotidyl transferase of unknown function (DUF1814); Region: DUF1814; cl00973 983545011613 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 983545011614 MAPEG family; Region: MAPEG; cl09190 983545011615 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl15754 983545011616 cofactor binding site; other site 983545011617 DNA binding site [nucleotide binding] 983545011618 substrate interaction site [chemical binding]; other site 983545011619 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl15754 983545011620 AIPR protein; Region: AIPR; pfam10592 983545011621 Domain of unknown function (DUF4420); Region: DUF4420; pfam14390 983545011622 Z1 domain; Region: Z1; pfam10593 983545011623 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 983545011624 Methyltransferase domain; Region: Methyltransf_31; pfam13847 983545011625 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 983545011626 S-adenosylmethionine binding site [chemical binding]; other site 983545011627 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cl00083 983545011628 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 983545011629 HipA N-terminal domain; Region: Couple_hipA; cl11853 983545011630 HipA-like N-terminal domain; Region: HipA_N; pfam07805 983545011631 HipA-like C-terminal domain; Region: HipA_C; pfam07804 983545011632 Secretin and TonB N terminus short domain; Region: STN; cl06624 983545011633 TonB-dependent receptor; Region: TonB-Xanth-Caul; TIGR01782 983545011634 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl00284 983545011635 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 983545011636 Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712 983545011637 FecR protein; Region: FecR; pfam04773 983545011638 RNA polymerase sigma-70 factor, Bacteroides expansion family 1; Region: Sig70_bacteroi1; TIGR02985 983545011639 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 983545011640 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 983545011641 DNA binding residues [nucleotide binding] 983545011642 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cd00838 983545011643 active site 983545011644 metal binding site [ion binding]; metal-binding site 983545011645 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl00284 983545011646 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl00284 983545011647 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 983545011648 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 983545011649 metal binding site [ion binding]; metal-binding site 983545011650 active site 983545011651 I-site; other site 983545011652 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 983545011653 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 983545011654 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 983545011655 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 983545011656 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 983545011657 putative PBP binding loops; other site 983545011658 ABC-ATPase subunit interface; other site 983545011659 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 983545011660 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 983545011661 dimer interface [polypeptide binding]; other site 983545011662 conserved gate region; other site 983545011663 putative PBP binding loops; other site 983545011664 ABC-ATPase subunit interface; other site 983545011665 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 983545011666 The N-terminal ATPase domain of the maltose transporter, MalK. ATP binding cassette (ABC) proteins function from bacteria to human, mediating the translocation of substances into and out of cells or organelles. ABC transporters contain two...; Region: ABC_MalK_N; cd03301 983545011667 Walker A/P-loop; other site 983545011668 ATP binding site [chemical binding]; other site 983545011669 Q-loop/lid; other site 983545011670 ABC transporter signature motif; other site 983545011671 Walker B; other site 983545011672 D-loop; other site 983545011673 H-loop/switch region; other site 983545011674 TOBE domain; Region: TOBE_2; cl01440 983545011675 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 983545011676 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 983545011677 motif I; other site 983545011678 active site 983545011679 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 983545011680 motif II; other site 983545011681 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 983545011682 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 983545011683 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 983545011684 Fructokinases (FRKs) mainly from bacteria and plants are enzymes with high specificity for fructose, as are all FRKs, but they catalyzes the conversion of fructose to fructose-6-phosphate, which is an entry point into glycolysis via conversion into...; Region: bac_FRK; cd01167 983545011685 putative substrate binding site [chemical binding]; other site 983545011686 putative ATP binding site [chemical binding]; other site 983545011687 Transcriptional regulator [Transcription]; Region: LysR; COG0583 983545011688 Helix-turn-helix domains; Region: HTH; cl00088 983545011689 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 983545011690 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 983545011691 Helix-turn-helix domains; Region: HTH; cl00088 983545011692 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 983545011693 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 983545011694 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 983545011695 AcrB/AcrD/AcrF family; Region: ACR_tran; pfam00873 983545011696 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 983545011697 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 983545011698 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 983545011699 putative substrate translocation pore; other site 983545011700 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 983545011701 Helix-turn-helix domains; Region: HTH; cl00088 983545011702 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 983545011703 GST_N family, Saccharomyces cerevisiae GTT2-like subfamily; composed of predominantly uncharacterized proteins with similarity to the S. cerevisiae GST protein, GTT2. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing...; Region: GST_N_GTT2_like; cd03051 983545011704 putative C-terminal domain interface [polypeptide binding]; other site 983545011705 putative GSH binding site (G-site) [chemical binding]; other site 983545011706 putative dimer interface [polypeptide binding]; other site 983545011707 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776 983545011708 N-terminal domain interface [polypeptide binding]; other site 983545011709 dimer interface [polypeptide binding]; other site 983545011710 substrate binding pocket (H-site) [chemical binding]; other site 983545011711 Cupin domain; Region: Cupin_2; cl09118 983545011712 periplasmic protein; Provisional; Region: PRK10568 983545011713 BON domain; Region: BON; cl02771 983545011714 BON domain; Region: BON; cl02771 983545011715 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 983545011716 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 983545011717 active site 983545011718 catalytic tetrad [active] 983545011719 Predicted membrane protein (DUF2254); Region: DUF2254; pfam10011 983545011720 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 983545011721 putative catalytic site [active] 983545011722 putative metal binding site [ion binding]; other site 983545011723 putative phosphate binding site [ion binding]; other site 983545011724 Domain of Unknown Function (DUF748); Region: DUF748; pfam05359 983545011725 Proteolipid membrane potential modulator; Region: Pmp3; cl00431 983545011726 Virulence factor BrkB; Region: Virul_fac_BrkB; cl07918 983545011727 Mechanosensitive ion channel; Region: MS_channel; pfam00924 983545011728 Na+/H+ antiporter 1; Region: Na_H_antiport_1; cl01133 983545011729 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 983545011730 gamma-glutamyl phosphate reductase; Region: proA; TIGR00407 983545011731 putative catalytic cysteine [active] 983545011732 gamma-glutamyl kinase; Provisional; Region: PRK13402 983545011733 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 983545011734 nucleotide binding site [chemical binding]; other site 983545011735 homotetrameric interface [polypeptide binding]; other site 983545011736 putative phosphate binding site [ion binding]; other site 983545011737 putative allosteric binding site; other site 983545011738 PUA domain; Region: PUA; cl00607 983545011739 Sodium:solute symporter family; Region: SSF; cl00456 983545011740 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 983545011741 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 983545011742 Helix-turn-helix domains; Region: HTH; cl00088 983545011743 Helix-turn-helix domains; Region: HTH; cl00088 983545011744 VacJ like lipoprotein; Region: VacJ; cl01073 983545011745 Predicted exporters of the RND superfamily [General function prediction only]; Region: COG1033 983545011746 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 983545011747 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 983545011748 active site 983545011749 phosphorylation site [posttranslational modification] 983545011750 intermolecular recognition site; other site 983545011751 dimerization interface [polypeptide binding]; other site 983545011752 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 983545011753 dimer interface [polypeptide binding]; other site 983545011754 phosphorylation site [posttranslational modification] 983545011755 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 983545011756 ATP binding site [chemical binding]; other site 983545011757 Mg2+ binding site [ion binding]; other site 983545011758 G-X-G motif; other site 983545011759 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 983545011760 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 983545011761 active site 983545011762 phosphorylation site [posttranslational modification] 983545011763 intermolecular recognition site; other site 983545011764 dimerization interface [polypeptide binding]; other site 983545011765 Response regulator receiver domain; Region: Response_reg; pfam00072 983545011766 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 983545011767 active site 983545011768 phosphorylation site [posttranslational modification] 983545011769 intermolecular recognition site; other site 983545011770 dimerization interface [polypeptide binding]; other site 983545011771 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 983545011772 active site 983545011773 phosphorylation site [posttranslational modification] 983545011774 intermolecular recognition site; other site 983545011775 dimerization interface [polypeptide binding]; other site 983545011776 CHASE3 domain; Region: CHASE3; cl05000 983545011777 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 983545011778 dimer interface [polypeptide binding]; other site 983545011779 phosphorylation site [posttranslational modification] 983545011780 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 983545011781 ATP binding site [chemical binding]; other site 983545011782 Mg2+ binding site [ion binding]; other site 983545011783 G-X-G motif; other site 983545011784 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 983545011785 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 983545011786 active site 983545011787 phosphorylation site [posttranslational modification] 983545011788 intermolecular recognition site; other site 983545011789 dimerization interface [polypeptide binding]; other site 983545011790 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 983545011791 Walker A motif; other site 983545011792 ATP binding site [chemical binding]; other site 983545011793 Walker B motif; other site 983545011794 arginine finger; other site 983545011795 Helix-turn-helix domains; Region: HTH; cl00088 983545011796 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 983545011797 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 983545011798 Coenzyme A binding pocket [chemical binding]; other site 983545011799 Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the 'double-glycine' leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic). The cleavage...; Region: Peptidase_C39_like; cl00296 983545011800 RimK-like ATPgrasp N-terminal domain; Region: RLAN; pfam14401 983545011801 Glutathione synthase/Ribosomal protein S6 modification enzyme (glutaminyl transferase) [Coenzyme metabolism / Translation, ribosomal structure and biogenesis]; Region: RimK; COG0189 983545011802 ATP-grasp domain; Region: ATP-grasp_4; cl03087 983545011803 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 983545011804 Domain of unknown function (DUF3471); Region: DUF3471; pfam11954 983545011805 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 983545011806 amidase catalytic site [active] 983545011807 Zn binding residues [ion binding]; other site 983545011808 substrate binding site [chemical binding]; other site 983545011809 Putative peptidoglycan binding domain; Region: PG_binding_1; cl15437 983545011810 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 983545011811 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383 983545011812 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971 983545011813 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_21; cd04680 983545011814 nudix motif; other site 983545011815 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 983545011816 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11557 983545011817 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 983545011818 putative active site [active] 983545011819 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl00284 983545011820 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl00284 983545011821 PepSY-associated TM helix; Region: PepSY_TM_2; cl15813 983545011822 Protein of unknown function (DUF1343); Region: DUF1343; cl01598 983545011823 N-acetylmuramic acid-6-phosphate etherase; Reviewed; Region: murQ; PRK05441 983545011824 N-acetylmuramic acid 6-phosphate etherase. Members of this family contain the SIS (Sugar ISomerase) domain. The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. The bacterial cell wall sugar N-acetylmuramic acid...; Region: SIS_Etherase; cd05007 983545011825 putative active site [active] 983545011826 Predicted N-acetylglucosamine kinase [Carbohydrate transport and metabolism]; Region: COG2971 983545011827 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 983545011828 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 983545011829 Sodium:solute symporter family; Region: SSF; cl00456 983545011830 SH3 domain of the SH3b1 type; Region: SH3_6; pfam12913 983545011831 SH3 domain of SH3b2 type; Region: SH3_7; pfam12914 983545011832 NlpC/P60 family; Region: NLPC_P60; cl11438 983545011833 Protein of unknown function (DUF819); Region: DUF819; cl02317 983545011834 Predicted phosphosugar isomerases [Cell envelope biogenesis, outer membrane]; Region: AgaS; COG2222 983545011835 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 983545011836 dimer interface [polypeptide binding]; other site 983545011837 active site 983545011838 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 983545011839 dimer interface [polypeptide binding]; other site 983545011840 active site 983545011841 N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820 983545011842 N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854 983545011843 active site 983545011844 dimer interface [polypeptide binding]; other site 983545011845 Fucose permease [Carbohydrate transport and metabolism]; Region: FucP; COG0738 983545011846 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cl11420 983545011847 LD-Carboxypeptidase, a serine protease, includes microcin C7 self immunity protein; Region: Peptidase_S66; cd07025 983545011848 dimer interface [polypeptide binding]; other site 983545011849 catalytic triad [active] 983545011850 Response regulator receiver domain; Region: Response_reg; pfam00072 983545011851 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 983545011852 active site 983545011853 phosphorylation site [posttranslational modification] 983545011854 intermolecular recognition site; other site 983545011855 dimerization interface [polypeptide binding]; other site 983545011856 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 983545011857 metal binding site [ion binding]; metal-binding site 983545011858 active site 983545011859 I-site; other site 983545011860 ABC transporter ATP-binding protein; Provisional; Region: PRK15064 983545011861 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 983545011862 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 983545011863 ABC transporter; Region: ABC_tran_2; pfam12848 983545011864 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 983545011865 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 983545011866 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 983545011867 dimer interface [polypeptide binding]; other site 983545011868 putative CheW interface [polypeptide binding]; other site 983545011869 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 983545011870 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 983545011871 dimer interface [polypeptide binding]; other site 983545011872 putative CheW interface [polypeptide binding]; other site 983545011873 Protein of unknown function (DUF2855); Region: DUF2855; pfam11017 983545011874 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 983545011875 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 983545011876 Helix-turn-helix domains; Region: HTH; cl00088 983545011877 WHG domain; Region: WHG; pfam13305 983545011878 Malic enzyme [Energy production and conversion]; Region: SfcA; COG0281 983545011879 Malic enzyme, N-terminal domain; Region: malic; pfam00390 983545011880 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 983545011881 putative NAD(P) binding site [chemical binding]; other site 983545011882 Ribosomal protein L31; Region: Ribosomal_L31; cl00377 983545011883 primosome assembly protein PriA; Validated; Region: PRK05580 983545011884 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 983545011885 ATP binding site [chemical binding]; other site 983545011886 putative Mg++ binding site [ion binding]; other site 983545011887 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 983545011888 cell division protein FtsN; Region: ftsN; TIGR02223 983545011889 Protein of unknown function (DUF1523); Region: DUF1523; pfam07509 983545011890 Sporulation related domain; Region: SPOR; cl10051 983545011891 Protease HslV and the ATPase/chaperone HslU are part of an ATP-dependent proteolytic system that is the prokaryotic homolog of the proteasome. HslV is a dimer of hexamers (a dodecamer) that forms a central proteolytic chamber with active sites on the...; Region: protease_HslV; cd01913 983545011892 active site 983545011893 HslU subunit interaction site [polypeptide binding]; other site 983545011894 ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201 983545011895 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 983545011896 Walker A motif; other site 983545011897 ATP binding site [chemical binding]; other site 983545011898 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 983545011899 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; cl11083 983545011900 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 983545011901 Peptidase_C39 like family; Region: Peptidase_C39_2; pfam13529 983545011902 A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the 'double-glycine' leader peptides from the precursors of various bacteriocins; Region: Peptidase_C39A; cd02549 983545011903 putative active site [active] 983545011904 Na+/H+ antiporter 1; Region: Na_H_antiport_1; cl01133 983545011905 transcriptional activator NhaR; Provisional; Region: nhaR; PRK11062 983545011906 Helix-turn-helix domains; Region: HTH; cl00088 983545011907 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 983545011908 dimerization interface [polypeptide binding]; other site 983545011909 Bacterial SH3 domain; Region: SH3_3; cl02551 983545011910 Bacterial SH3 domain; Region: SH3_3; cl02551 983545011911 Bacterial SH3 domain; Region: SH3_3; cl02551 983545011912 Protein of unknown function (DUF3380); Region: DUF3380; pfam11860 983545011913 Uncharacterized protein related to glutamine synthetase [General function prediction only]; Region: COG3968 983545011914 Glutamine synthetase type III N terminal; Region: GSIII_N; pfam12437 983545011915 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 983545011916 preprotein translocase subunit SecD; Reviewed; Region: secD; PRK12933 983545011917 SecD export protein N-terminal TM region; Region: SecD-TM1; cl08136 983545011918 SecD/SecF GG Motif; Region: Sec_GG; pfam07549 983545011919 Protein export membrane protein; Region: SecD_SecF; cl14618 983545011920 preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13021 983545011921 Protein export membrane protein; Region: SecD_SecF; cl14618 983545011922 Uncharacterized ACR, YagE family COG1723; Region: DUF155; cl00751 983545011923 glutathione reductase; Validated; Region: PRK06116 983545011924 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 983545011925 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 983545011926 Zn-dependent oligopeptidases [Amino acid transport and metabolism]; Region: Dcp; COG0339 983545011927 Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456 983545011928 active site 983545011929 Zn binding site [ion binding]; other site 983545011930 Methyladenine glycosylase; Region: Adenine_glyco; cl01059 983545011931 ubiE/COQ5 methyltransferase family; Region: Ubie_methyltran; pfam01209 983545011932 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 983545011933 S-adenosylmethionine binding site [chemical binding]; other site 983545011934 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3165 983545011935 SCP-2 sterol transfer family; Region: SCP2; cl01225 983545011936 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 983545011937 Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661 983545011938 mttA/Hcf106 family; Region: MttA_Hcf106; cl00788 983545011939 mttA/Hcf106 family; Region: MttA_Hcf106; cl00788 983545011940 Sec-independent protein translocase protein (TatC); Region: TatC; cl00521 983545011941 Protein of unknown function (DUF3121); Region: DUF3121; cl11879 983545011942 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 983545011943 active site 983545011944 7TMR-DISM extracellular 2; Region: 7TMR-DISMED2; pfam07696 983545011945 7TM diverse intracellular signalling; Region: 7TMR-DISM_7TM; pfam07695 983545011946 type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843 983545011947 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 983545011948 metal binding site [ion binding]; metal-binding site 983545011949 active site 983545011950 I-site; other site 983545011951 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS_aspartate_rich; cd04823 983545011952 dimer interface [polypeptide binding]; other site 983545011953 active site 983545011954 aspartate-rich active site metal binding site; other site 983545011955 allosteric magnesium binding site [ion binding]; other site 983545011956 Schiff base residues; other site 983545011957 guanosine pentaphosphate phosphohydrolase; Provisional; Region: PRK11031 983545011958 Ppx/GppA phosphatase family; Region: Ppx-GppA; cl15449 983545011959 ATP-dependent RNA helicase RhlB; Provisional; Region: PRK04837 983545011960 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 983545011961 ATP binding site [chemical binding]; other site 983545011962 Mg++ binding site [ion binding]; other site 983545011963 motif III; other site 983545011964 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 983545011965 nucleotide binding region [chemical binding]; other site 983545011966 ATP-binding site [chemical binding]; other site 983545011967 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 983545011968 catalytic residues [active] 983545011969 transcription termination factor Rho; Provisional; Region: rho; PRK09376 983545011970 Rho termination factor, N-terminal domain; Region: Rho_N; cl06505 983545011971 Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459 983545011972 RNA binding site [nucleotide binding]; other site 983545011973 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128 983545011974 multimer interface [polypeptide binding]; other site 983545011975 Walker A motif; other site 983545011976 ATP binding site [chemical binding]; other site 983545011977 Walker B motif; other site 983545011978 AIR carboxylase; Region: AIRC; cl00310 983545011979 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 983545011980 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 983545011981 ATP-grasp domain; Region: ATP-grasp_4; cl03087 983545011982 3-ketoacyl-CoA thiolase; Reviewed; Region: fadA; PRK08947 983545011983 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 983545011984 dimer interface [polypeptide binding]; other site 983545011985 active site 983545011986 multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadB; PRK11730 983545011987 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 983545011988 substrate binding site [chemical binding]; other site 983545011989 oxyanion hole (OAH) forming residues; other site 983545011990 trimer interface [polypeptide binding]; other site 983545011991 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 983545011992 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 983545011993 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 983545011994 lytic murein transglycosylase; Provisional; Region: PRK11619 983545011995 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic 'goose-type' lysozymes (GEWL). LTs catalyze...; Region: LT_GEWL; cd00254 983545011996 N-acetyl-D-glucosamine binding site [chemical binding]; other site 983545011997 catalytic residue [active] 983545011998 proline dipeptidase; Provisional; Region: PRK13607 983545011999 Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on...; Region: Prolidase; cd01087 983545012000 active site 983545012001 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 983545012002 NfeD-like C-terminal, partner-binding; Region: NfeD; cl00686 983545012003 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 983545012004 GST_N family, unknown subfamily 4; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_4; cd03056 983545012005 putative C-terminal domain interface [polypeptide binding]; other site 983545012006 putative GSH binding site (G-site) [chemical binding]; other site 983545012007 putative dimer interface [polypeptide binding]; other site 983545012008 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776 983545012009 N-terminal domain interface [polypeptide binding]; other site 983545012010 dimer interface [polypeptide binding]; other site 983545012011 substrate binding pocket (H-site) [chemical binding]; other site 983545012012 Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; cl00398 983545012013 Putative modulator of DNA gyrase; Region: PmbA_TldD; pfam01523 983545012014 Protein of unknown function (DUF615); Region: DUF615; cl01147 983545012015 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383 983545012016 Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; cl00398 983545012017 Putative modulator of DNA gyrase; Region: PmbA_TldD; pfam01523 983545012018 Predicted amidohydrolase [General function prediction only]; Region: COG0388 983545012019 Nit1, Nit 2, and related proteins, and the Nit1-like domain of NitFhit (class 10 nitrilases); Region: nit; cd07572 983545012020 putative active site [active] 983545012021 catalytic triad [active] 983545012022 dimer interface [polypeptide binding]; other site 983545012023 TIGR02099 family protein; Region: TIGR02099 983545012024 AsmA-like C-terminal region; Region: AsmA_2; cl15864 983545012025 ribonuclease G; Provisional; Region: PRK11712 983545012026 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 983545012027 homodimer interface [polypeptide binding]; other site 983545012028 oligonucleotide binding site [chemical binding]; other site 983545012029 Maf-like protein; Region: Maf; pfam02545 983545012030 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 983545012031 active site 983545012032 dimer interface [polypeptide binding]; other site 983545012033 rod shape-determining protein MreD; Region: MreD; cl01087 983545012034 rod shape-determining protein MreC; Provisional; Region: PRK13922 983545012035 rod shape-determining protein MreC; Region: MreC; pfam04085 983545012036 rod shape-determining protein MreB; Provisional; Region: PRK13927 983545012037 Actin; An ubiquitous protein involved in the formation of filaments that are a major component of the cytoskeleton. Interaction with myosin provides the basis of muscular contraction and many aspects of cell motility. Each actin protomer binds one...; Region: ACTIN; cl11528 983545012038 ATP binding site [chemical binding]; other site 983545012039 profilin binding site; other site 983545012040 CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast; Region: CUB; cd00041 983545012041 heterodimerization interface [polypeptide binding]; other site 983545012042 Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of...; Region: LamG; cl00102 983545012043 Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of...; Region: LamG; cl00102 983545012044 Tfp pilus assembly protein PilV [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilV; COG4967 983545012045 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; cl06830 983545012046 Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459 983545012047 Type II secretion system (T2SS), protein F; Region: T2SF; cl00906 983545012048 Type II secretion system (T2SS), protein F; Region: T2SF; cl00906 983545012049 type IV-A pilus assembly ATPase PilB; Region: type_IV_pilB; TIGR02538 983545012050 Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157 983545012051 PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129 983545012052 Walker A motif; other site 983545012053 ATP binding site [chemical binding]; other site 983545012054 Walker B motif; other site 983545012055 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 983545012056 binding surface 983545012057 TPR motif; other site 983545012058 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 983545012059 TPR motif; other site 983545012060 binding surface 983545012061 putative secretion ATPase, PEP-CTERM locus subfamily; Region: pepcterm_ATPase; TIGR03015 983545012062 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 983545012063 Walker A motif; other site 983545012064 ATP binding site [chemical binding]; other site 983545012065 Walker B motif; other site 983545012066 arginine finger; other site 983545012067 Secretin and TonB N terminus short domain; Region: STN; cl06624 983545012068 Secretin N-terminal domain; Region: Secretin_N_2; pfam07655 983545012069 pilus (MSHA type) biogenesis protein MshL; Region: pilus_MshL; TIGR02519 983545012070 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 983545012071 Tfp pilus assembly protein PilN [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilN; COG3166 983545012072 Fimbrial assembly protein (PilN); Region: PilN; pfam05137 983545012073 Domain of unknown function (DUF1338); Region: DUF1338; cl02226 983545012074 Arginine N-succinyltransferase beta subunit; Region: AstA; cl11440 983545012075 bifunctional N-succinyldiaminopimelate-aminotransferase/acetylornithine transaminase protein; Reviewed; Region: argD; PRK05093 983545012076 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 983545012077 inhibitor-cofactor binding pocket; inhibition site 983545012078 pyridoxal 5'-phosphate binding site [chemical binding]; other site 983545012079 catalytic residue [active] 983545012080 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 983545012081 Helix-turn-helix domains; Region: HTH; cl00088 983545012082 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl09944 983545012083 active site 983545012084 phosphorylation site [posttranslational modification] 983545012085 intermolecular recognition site; other site 983545012086 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 983545012087 active site 983545012088 phosphorylation site [posttranslational modification] 983545012089 intermolecular recognition site; other site 983545012090 dimerization interface [polypeptide binding]; other site 983545012091 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 983545012092 metal binding site [ion binding]; metal-binding site 983545012093 active site 983545012094 I-site; other site 983545012095 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 983545012096 Helix-turn-helix domains; Region: HTH; cl00088 983545012097 methylamine dehydrogenase heavy chain; Region: TTQ_MADH_Hv; TIGR02658 983545012098 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 983545012099 Methylamine dehydrogenase, L chain; Region: Me-amine-dh_L; cl03812 983545012100 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 983545012101 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 983545012102 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 983545012103 N-terminal plug; other site 983545012104 ligand-binding site [chemical binding]; other site 983545012105 AMP-binding domain protein; Validated; Region: PRK08315 983545012106 AMP-binding enzyme; Region: AMP-binding; cl15778 983545012107 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 983545012108 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 983545012109 Streptomyces aureofaciens putative aldehyde dehydrogenase AldA (AAD23400)-like; Region: ALDH_AldA-AAD23400; cd07106 983545012110 NAD(P) binding site [chemical binding]; other site 983545012111 catalytic residues [active] 983545012112 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2849 983545012113 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2849 983545012114 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2849 983545012115 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 983545012116 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 983545012117 N-terminal plug; other site 983545012118 ligand-binding site [chemical binding]; other site 983545012119 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 983545012120 dimer interface [polypeptide binding]; other site 983545012121 ssDNA binding site [nucleotide binding]; other site 983545012122 tetramer (dimer of dimers) interface [polypeptide binding]; other site 983545012123 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 983545012124 Major Facilitator Superfamily; Region: MFS_1; pfam07690 983545012125 putative substrate translocation pore; other site 983545012126 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 983545012127 The excision repair protein UvrA domain I; Nucleotide excision repair in eubacteria is a process that repairs DNA damage by the removal of a 12-13-mer oligonucleotide containing the lesion. Recognition and cleavage of the damaged DNA is a multistep...; Region: ABC_UvrA_I; cd03270 983545012128 The excision repair protein UvrA domain I; Nucleotide excision repair in eubacteria is a process that repairs DNA damage by the removal of a 12-13-mer oligonucleotide containing the lesion. Recognition and cleavage of the damaged DNA is a multistep...; Region: ABC_UvrA_I; cd03270 983545012129 The excision repair protein UvrA domain II; Nucleotide excision repair in eubacteria is a process that repairs DNA damage by the removal of a 12-13-mer oligonucleotide containing the lesion. Recognition and cleavage of the damaged DNA is a multistep...; Region: ABC_UvrA_II; cd03271 983545012130 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 983545012131 active site 983545012132 Prolyl 4-hydroxylase alpha subunit homologues; Region: P4Hc; smart00702 983545012133 Protein of unknown function (DUF3299); Region: DUF3299; cl01387 983545012134 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 983545012135 putative substrate translocation pore; other site 983545012136 Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412 983545012137 dimer interface [polypeptide binding]; other site 983545012138 substrate binding site [chemical binding]; other site 983545012139 metal binding sites [ion binding]; metal-binding site 983545012140 haloacid dehalogenase superfamily, subfamily IA, variant 3 with third motif having DD or ED; Region: HAD-SF-IA-v3; TIGR01509 983545012141 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 983545012142 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 983545012143 motif II; other site 983545012144 adenosine nucleotide hydrolase NudE; Provisional; Region: nudE; PRK11762 983545012145 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 983545012146 dimer interface [polypeptide binding]; other site 983545012147 ADP-ribose binding site [chemical binding]; other site 983545012148 active site 983545012149 nudix motif; other site 983545012150 metal binding site [ion binding]; metal-binding site 983545012151 CysQ, a 3'-Phosphoadenosine-5'-phosphosulfate (PAPS) 3'-phosphatase, is a bacterial member of the inositol monophosphatase family. It has been proposed that CysQ helps control intracellular levels of PAPS, which is an intermediate in cysteine...; Region: CysQ; cd01638 983545012152 active site 983545012153 YceI-like domain; Region: YceI; cl01001 983545012154 Uncharacterized protein family (UPF0270); Region: UPF0270; cl01180 983545012155 putative hydrolase; Provisional; Region: PRK10985 983545012156 Conserved hypothetical protein 698; Region: Cons_hypoth698; cl01075 983545012157 Helix-turn-helix domains; Region: HTH; cl00088 983545012158 aminoethylphosphonate catabolism associated LysR family transcriptional regulator; Region: phn_lysR; TIGR03339 983545012159 C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420 983545012160 putative dimerization interface [polypeptide binding]; other site 983545012161 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 983545012162 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 983545012163 putative ABC transporter ATP-binding protein; Provisional; Region: PRK10636 983545012164 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 983545012165 Walker A/P-loop; other site 983545012166 ATP binding site [chemical binding]; other site 983545012167 Q-loop/lid; other site 983545012168 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 983545012169 ABC transporter; Region: ABC_tran_2; pfam12848 983545012170 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 983545012171 Probable metal-binding protein (DUF2387); Region: DUF2387; cl01410 983545012172 SlyX; Region: SlyX; cl01090 983545012173 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 983545012174 structural tetrad; other site 983545012175 Domain amino terminal to FKBP-type peptidyl-prolyl isomerase; Region: FKBP_N; pfam01346 983545012176 FKBP-type peptidyl-prolyl cis-trans isomerases 1 [Posttranslational modification, protein turnover, chaperones]; Region: FkpA; COG0545 983545012177 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; cl11587 983545012178 transcription elongation factor GreB; Reviewed; Region: greB; PRK01885 983545012179 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 983545012180 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 983545012181 Transcriptional accessory protein [Transcription]; Region: Tex; COG2183 983545012182 Tex-like protein N-terminal domain; Region: Tex_N; pfam09371 983545012183 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD includes...; Region: RuvC_resolvase; cl00243 983545012184 S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685 983545012185 RNA binding site [nucleotide binding]; other site 983545012186 SprA-related family; Region: SprA-related; pfam12118 983545012187 putative pimeloyl-BioC--CoA transferase BioH; Region: bioH; TIGR01738 983545012188 DNA utilization protein GntX; Provisional; Region: PRK11595 983545012189 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 983545012190 active site 983545012191 Peptidase M14-like domain; uncharacterized subgroup; Region: M14-like_1_1; cd06238 983545012192 putative active site [active] 983545012193 Zn binding site [ion binding]; other site 983545012194 Fe/S biogenesis protein NfuA; Provisional; Region: PRK11190 983545012195 Iron-sulphur cluster biosynthesis; Region: Fe-S_biosyn; cl00400 983545012196 NifU-like domain; Region: NifU; cl00484 983545012197 DNA-damage-inducible SOS response protein; Provisional; Region: PRK10367 983545012198 MatE; Region: MatE; cl10513 983545012199 MatE; Region: MatE; cl10513 983545012200 Putative catalytic NodB homology domain of uncharacterized bacterial polysaccharide deacetylases which consist of a 5-stranded beta/alpha barrel; Region: CE4_DAC_u4_5s; cd10973 983545012201 putative active site [active] 983545012202 putative metal binding site [ion binding]; other site 983545012203 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 983545012204 SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968 983545012205 Cu(I) binding site [ion binding]; other site 983545012206 UbiA prenyltransferase family; Region: UbiA; cl00337 983545012207 Cytochrome oxidase assembly protein; Region: COX15-CtaA; cl15852 983545012208 SURF1 superfamily. Surf1/Shy1 has been implicated in the posttranslational steps of the biogenesis of the mitochondrially-encoded Cox1 subunit of cytochrome c oxidase (complex IV). Cytochrome c oxidase (complex IV), the terminal electron-transferring...; Region: SURF1; cd06662 983545012209 Protein of unknown function (DUF2909); Region: DUF2909; pfam11137 983545012210 Cytochrome c oxidase subunit III. Cytochrome c oxidase (CcO), the terminal oxidase in the respiratory chains of eukaryotes and most bacteria, is a multi-chain transmembrane protein located in the inner membrane of mitochondria and the cell membrane of...; Region: Cyt_c_Oxidase_III; cd01665 983545012211 Subunit III/VIIa interface [polypeptide binding]; other site 983545012212 Phospholipid binding site [chemical binding]; other site 983545012213 Subunit I/III interface [polypeptide binding]; other site 983545012214 Subunit III/VIb interface [polypeptide binding]; other site 983545012215 Subunit III/VIa interface; other site 983545012216 Subunit III/Vb interface [polypeptide binding]; other site 983545012217 Cytochrome c oxidase assembly protein CtaG/Cox11; Region: CtaG_Cox11; cl01240 983545012218 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 983545012219 Cytochrome C oxidase subunit I. Cytochrome c oxidase (CcO), the terminal oxidase in the respiratory chains of eukaryotes and most bacteria, is a multi-chain transmembrane protein located in the inner membrane of mitochondria and the cell membrane of...; Region: Cyt_c_Oxidase_I; cd01663 983545012220 Subunit I/III interface [polypeptide binding]; other site 983545012221 D-pathway; other site 983545012222 Subunit I/VIIc interface [polypeptide binding]; other site 983545012223 Subunit I/IV interface [polypeptide binding]; other site 983545012224 Subunit I/II interface [polypeptide binding]; other site 983545012225 Low-spin heme (heme a) binding site [chemical binding]; other site 983545012226 Subunit I/VIIa interface [polypeptide binding]; other site 983545012227 Subunit I/VIa interface [polypeptide binding]; other site 983545012228 Dimer interface; other site 983545012229 Putative water exit pathway; other site 983545012230 Binuclear center (heme a3/CuB) [ion binding]; other site 983545012231 K-pathway; other site 983545012232 Subunit I/Vb interface [polypeptide binding]; other site 983545012233 Putative proton exit pathway; other site 983545012234 Subunit I/VIb interface; other site 983545012235 Subunit I/VIc interface [polypeptide binding]; other site 983545012236 Electron transfer pathway; other site 983545012237 Subunit I/VIIIb interface [polypeptide binding]; other site 983545012238 Subunit I/VIIb interface [polypeptide binding]; other site 983545012239 Cytochrome C oxidase subunit II, transmembrane domain; Region: COX2_TM; pfam02790 983545012240 cytochrome c oxidase, subunit II; Region: CoxB; TIGR02866 983545012241 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; cl11412 983545012242 Cytochrome c [Energy production and conversion]; Region: COG3258 983545012243 Cytochrome c; Region: Cytochrom_C; cl11414 983545012244 LexA repressor; Validated; Region: PRK00215 983545012245 Helix-turn-helix domains; Region: HTH; cl00088 983545012246 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 983545012247 Catalytic site [active] 983545012248 Glycerol-3-phosphate O-acyltransferase [Lipid metabolism]; Region: PlsB; COG2937 983545012249 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: GPAT-like; Region: LPLAT_DHAPAT-like; cd07993 983545012250 putative acyl-acceptor binding pocket; other site 983545012251 threonine dehydratase; Reviewed; Region: PRK09224 983545012252 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 983545012253 tetramer interface [polypeptide binding]; other site 983545012254 pyridoxal 5'-phosphate binding site [chemical binding]; other site 983545012255 catalytic residue [active] 983545012256 First of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_1; cd04906 983545012257 putative Ile/Val binding site [chemical binding]; other site 983545012258 Second of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_2; cd04907 983545012259 putative Ile/Val binding site [chemical binding]; other site 983545012260 Dehydratase family; Region: ILVD_EDD; cl00340 983545012261 Predicted membrane protein [Function unknown]; Region: COG2860 983545012262 UPF0126 domain; Region: UPF0126; pfam03458 983545012263 UPF0126 domain; Region: UPF0126; pfam03458 983545012264 Mg chelatase-related protein; Region: TIGR00368 983545012265 Subunit ChlI of Mg-chelatase; Region: ChlI; cl12214 983545012266 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 983545012267 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335 983545012268 Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182 983545012269 PepSY-associated TM helix; Region: PepSY_TM_2; cl15813 983545012270 Helix-turn-helix domains; Region: HTH; cl00088 983545012271 DNA-binding transcriptional regulator IlvY; Provisional; Region: PRK11716 983545012272 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 983545012273 dimerization interface [polypeptide binding]; other site 983545012274 ketol-acid reductoisomerase; Validated; Region: PRK05225 983545012275 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 983545012276 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 983545012277 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 983545012278 putative outer membrane lipoprotein; Provisional; Region: PRK10510 983545012279 Glycine zipper 2TM domain; Region: Rick_17kDa_Anti; cl10470 983545012280 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 983545012281 ligand binding site [chemical binding]; other site 983545012282 drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710 983545012283 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 983545012284 putative substrate translocation pore; other site 983545012285 EamA-like transporter family; Region: EamA; cl01037 983545012286 hypothetical protein; Provisional; Region: PRK08262 983545012287 M20 Peptidase, carboxypeptidase yscS; Region: M20_yscS; cd05674 983545012288 metal binding site [ion binding]; metal-binding site 983545012289 Invasion associated locus B (IalB) protein; Region: IalB; cl02207 983545012290 Nidogen-like; Region: NIDO; cl02648 983545012291 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 983545012292 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 983545012293 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 983545012294 gamma-glutamyl phosphate reductase; Region: proA; TIGR00407 983545012295 putative catalytic cysteine [active] 983545012296 gamma-glutamyl kinase; Provisional; Region: PRK05429 983545012297 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 983545012298 nucleotide binding site [chemical binding]; other site 983545012299 homotetrameric interface [polypeptide binding]; other site 983545012300 putative phosphate binding site [ion binding]; other site 983545012301 putative allosteric binding site; other site 983545012302 PUA domain; Region: PUA; cl00607 983545012303 Peptidase M1 family containing bacterial Aminopeptidase N; Region: M1_APN_5; cd09604 983545012304 Zn binding site [ion binding]; other site 983545012305 pheromone autoinducer 2 transporter; Reviewed; Region: tqsA; cl00465 983545012306 Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; cl01132 983545012307 Protein of unknown function (DUF3014); Region: DUF3014; pfam11219 983545012308 Protein of unknown function (DUF1285); Region: DUF1285; cl01571 983545012309 Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228 983545012310 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 983545012311 Metallo-dependent hydrolases, subgroup A is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_A; cd01299 983545012312 active site 983545012313 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 983545012314 SirA (also known as UvrY, and YhhP) belongs to a family of two-component response regulators that controls secondary metabolism and virulence. The other member of this two-component system is a sensor kinase called BarA which phosphorylates SirA. A...; Region: SirA; cd03423 983545012315 CPxP motif; other site 983545012316 orotate phosphoribosyltransferase; Validated; Region: pyrE; PRK00455 983545012317 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 983545012318 active site 983545012319 ribonuclease PH; Reviewed; Region: rph; PRK00173 983545012320 Ribonuclease PH; Region: RNase_PH_bact; cd11362 983545012321 hexamer interface [polypeptide binding]; other site 983545012322 active site 983545012323 hypothetical protein; Provisional; Region: PRK11820 983545012324 YicC-like family, N-terminal region; Region: YicC_N; pfam03755 983545012325 Domain of unknown function (DUF1732); Region: DUF1732; pfam08340 983545012326 Sulfate transporter family; Region: Sulfate_transp; cl15842 983545012327 Sulfate transporter family; Region: Sulfate_transp; cl15842 983545012328 Sulfate transporter family; Region: Sulfate_transp; cl15842 983545012329 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 983545012330 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 983545012331 putative substrate translocation pore; other site 983545012332 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 983545012333 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 983545012334 putative substrate translocation pore; other site 983545012335 DNA-binding transcriptional activator XapR; Provisional; Region: PRK09986 983545012336 Helix-turn-helix domains; Region: HTH; cl00088 983545012337 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 983545012338 dimerization interface [polypeptide binding]; other site 983545012339 substrate binding pocket [chemical binding]; other site 983545012340 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 983545012341 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 983545012342 short chain dehydrogenase; Provisional; Region: PRK06179 983545012343 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 983545012344 NADP binding site [chemical binding]; other site 983545012345 active site 983545012346 steroid binding site; other site 983545012347 Domain of unknown function (DUF3391); Region: DUF3391; pfam11871 983545012348 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 983545012349 Zn2+ binding site [ion binding]; other site 983545012350 Mg2+ binding site [ion binding]; other site 983545012351 TonB-dependent receptor; Region: TonB-Xanth-Caul; TIGR01782 983545012352 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl00284 983545012353 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl00284 983545012354 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl00284 983545012355 SapC; Region: SapC; pfam07277 983545012356 JmjC domain, hydroxylase; Region: JmjC; cl15814 983545012357 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 983545012358 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 983545012359 DNA binding site [nucleotide binding] 983545012360 active site 983545012361 DTW domain; Region: DTW; cl01221 983545012362 7TM diverse intracellular signalling; Region: 7TMR-DISM_7TM; pfam07695 983545012363 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 983545012364 dimer interface [polypeptide binding]; other site 983545012365 phosphorylation site [posttranslational modification] 983545012366 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 983545012367 ATP binding site [chemical binding]; other site 983545012368 Mg2+ binding site [ion binding]; other site 983545012369 G-X-G motif; other site 983545012370 Response regulator receiver domain; Region: Response_reg; pfam00072 983545012371 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 983545012372 active site 983545012373 phosphorylation site [posttranslational modification] 983545012374 intermolecular recognition site; other site 983545012375 dimerization interface [polypeptide binding]; other site 983545012376 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cl00086 983545012377 F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571 983545012378 ATP synthase, Delta/Epsilon chain, beta-sandwich domain; Region: ATP-synt_DE_N; cl10033 983545012379 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 983545012380 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; cl15275 983545012381 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 983545012382 alpha subunit interaction interface [polypeptide binding]; other site 983545012383 Walker A motif; other site 983545012384 ATP binding site [chemical binding]; other site 983545012385 Walker B motif; other site 983545012386 inhibitor binding site; inhibition site 983545012387 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 983545012388 ATP synthase; Region: ATP-synt; cl00365 983545012389 F0F1 ATP synthase subunit gamma; Provisional; Region: PRK13422 983545012390 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 983545012391 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; cl15275 983545012392 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 983545012393 beta subunit interaction interface [polypeptide binding]; other site 983545012394 Walker A motif; other site 983545012395 ATP binding site [chemical binding]; other site 983545012396 Walker B motif; other site 983545012397 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 983545012398 Plant ATP synthase F0; Region: YMF19; cl07975 983545012399 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 983545012400 Plant ATP synthase F0; Region: YMF19; cl07975 983545012401 F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711 983545012402 ATP synthase subunit C; Region: ATP-synt_C; cl00466 983545012403 ATP synthase A chain; Region: ATP-synt_A; cl00413 983545012404 ATP synthase I chain; Region: ATP_synt_I; cl09170 983545012405 ParB-like partition proteins; Region: parB_part; TIGR00180 983545012406 ParB-like nuclease domain; Region: ParBc; cl02129 983545012407 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 983545012408 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 983545012409 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl15754 983545012410 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 983545012411 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 983545012412 GidA associated domain 3; Region: GIDA_assoc_3; pfam13932 983545012413 hypothetical protein; Validated; Region: PRK08116 983545012414 Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; cl09153 983545012415 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 983545012416 tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291 983545012417 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 983545012418 trmE is a tRNA modification GTPase; Region: trmE; cd04164 983545012419 G1 box; other site 983545012420 GTP/Mg2+ binding site [chemical binding]; other site 983545012421 Switch I region; other site 983545012422 G2 box; other site 983545012423 Switch II region; other site 983545012424 G3 box; other site 983545012425 G4 box; other site 983545012426 G5 box; other site 983545012427 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 983545012428 Protein of unknown function (DUF520); Region: DUF520; cl00723 983545012429 membrane protein insertase; Provisional; Region: PRK01318 983545012430 60Kd inner membrane protein; Region: 60KD_IMP; cl00489 983545012431 Haemolytic domain; Region: Haemolytic; cl00506 983545012432 Ribonuclease P; Region: Ribonuclease_P; cl00457 983545012433 Ribosomal protein L34; Region: Ribosomal_L34; cl00370 983545012434 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 983545012435 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 983545012436 Ligand Binding Site [chemical binding]; other site 983545012437 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 983545012438 MPN+ (JAMM) motif; other site 983545012439 Zinc-binding site [ion binding]; other site 983545012440 AAA domain; Region: AAA_28; pfam13521 983545012441 Domain of unknown function (DUF4121); Region: DUF4121; pfam13497 983545012442 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl15754 983545012443 cofactor binding site; other site 983545012444 DNA binding site [nucleotide binding] 983545012445 substrate interaction site [chemical binding]; other site 983545012446 Uncharacterized protein conserved in bacteria (DUF2136); Region: DUF2136; cl01912 983545012447 Predicted transcription regulator containing HTH domain [Transcription]; Region: COG5499 983545012448 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 983545012449 non-specific DNA binding site [nucleotide binding]; other site 983545012450 salt bridge; other site 983545012451 sequence-specific DNA binding site [nucleotide binding]; other site 983545012452 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 983545012453 Active Sites [active] 983545012454 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 983545012455 Catalytic site [active] 983545012456 Nucleoid-associated protein [General function prediction only]; Region: COG3081 983545012457 37-kD nucleoid-associated bacterial protein; Region: NA37; cl15473 983545012458 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cl00065 983545012459 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 983545012460 Interdomain contacts; other site 983545012461 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cl00065 983545012462 Salmonella virulence plasmid 65kDa B protein; Region: SpvB; pfam03534 983545012463 Family description; Region: VCBS; pfam13517 983545012464 Insecticide toxin TcdB middle/N-terminal region; Region: TcdB_toxin_midN; pfam12256 983545012465 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 983545012466 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 983545012467 Y-family of DNA polymerases; Region: PolY; cl12025 983545012468 DNA binding site [nucleotide binding] 983545012469 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 983545012470 DNA binding site [nucleotide binding] 983545012471 active site 983545012472 Int/Topo IB signature motif; other site 983545012473 Dot/Icm secretion system ATPase DotB; Region: dot_icm_DotB; TIGR02524 983545012474 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 983545012475 Walker A motif; other site 983545012476 ATP binding site [chemical binding]; other site 983545012477 Walker B motif; other site 983545012478 StbA protein; Region: StbA; pfam06406 983545012479 Protein of unknown function (DUF1566); Region: DUF1566; pfam07603 983545012480 Protein of unknown function (DUF1566); Region: DUF1566; pfam07603 983545012481 TraM recognition site of TraD and TraG; Region: TraG-D_C; pfam12696 983545012482 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4643 983545012483 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 983545012484 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 983545012485 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 983545012486 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 983545012487 Macrophage killing protein with similarity to conjugation protein; Region: IcmL; pfam11393 983545012488 Protein of unknown function (DUF3625); Region: DUF3625; pfam12293 983545012489 AAA-like domain; Region: AAA_10; pfam12846 983545012490 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 983545012491 DNA binding site [nucleotide binding] 983545012492 Int/Topo IB signature motif; other site 983545012493 active site 983545012494 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 983545012495 active site 2 [active] 983545012496 active site 1 [active] 983545012497 Glutathione-dependent formaldehyde-activating enzyme; Region: GFA; cl01553 983545012498 Tn3 transposase DDE domain; Region: DDE_Tnp_Tn3; cl14901 983545012499 Tn3 transposase DDE domain; Region: DDE_Tnp_Tn3; cl14901 983545012500 tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225 983545012501 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 983545012502 DNA binding site [nucleotide binding] 983545012503 Int/Topo IB signature motif; other site 983545012504 active site 983545012505 Transposase zinc-binding domain; Region: Zn_Tnp_IS91; pfam14319 983545012506 Putative transposase; Region: Y2_Tnp; pfam04986 983545012507 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 983545012508 Cellular and retroviral pepsin-like aspartate proteases; Region: pepsin_retropepsin_like; cl11403 983545012509 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 983545012510 IHF dimer interface [polypeptide binding]; other site 983545012511 IHF - DNA interface [nucleotide binding]; other site 983545012512 cyclic-di-GMP phosphodiesterase; Provisional; Region: PRK11359 983545012513 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 983545012514 putative active site [active] 983545012515 heme pocket [chemical binding]; other site 983545012516 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 983545012517 metal binding site [ion binding]; metal-binding site 983545012518 active site 983545012519 I-site; other site 983545012520 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 983545012521 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 983545012522 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 983545012523 NAD(P) binding site [chemical binding]; other site 983545012524 active site 983545012525 Vitamin K epoxide reductase family; Region: VKOR; cl01729 983545012526 Tn3 transposase DDE domain; Region: DDE_Tnp_Tn3; cl14901 983545012527 Tn3 transposase DDE domain; Region: DDE_Tnp_Tn3; cl14901 983545012528 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 983545012529 DNA binding residues [nucleotide binding] 983545012530 putative mercuric reductase; Provisional; Region: PRK13748 983545012531 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 983545012532 metal-binding site [ion binding] 983545012533 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 983545012534 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 983545012535 MerC mercury resistance protein; Region: MerC; cl03934 983545012536 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 983545012537 metal-binding site [ion binding] 983545012538 MerT mercuric transport protein; Region: MerT; cl03578 983545012539 Helix-Turn-Helix DNA binding domain of the MerR1 transcription regulator; Region: HTH_MerR1; cd04783 983545012540 Hg(II)-responsive transcriptional regulator; Region: MerR; TIGR02051 983545012541 DNA binding residues [nucleotide binding] 983545012542 dimer interface [polypeptide binding]; other site 983545012543 mercury binding site [ion binding]; other site 983545012544 Cre recombinase, C-terminal catalytic domain. Cre-like recombinases belong to the superfamily of DNA breaking-rejoining enzymes, which share the same fold in their catalytic domain and the overall reaction mechanism. The bacteriophage P1 Cre...; Region: INT_Cre; cd00799 983545012545 DNA binding site [nucleotide binding] 983545012546 dimer interface [polypeptide binding]; other site 983545012547 Int/Topo IB signature motif; other site 983545012548 active site 983545012549 Uncharacterized BCR, YnfA/UPF0060 family; Region: UPF0060; cl00757 983545012550 exosortase A system-associated amidotransferase 1; Region: eps_aminotran_1; TIGR03108 983545012551 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 983545012552 active site 983545012553 dimer interface [polypeptide binding]; other site 983545012554 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 983545012555 Ligand Binding Site [chemical binding]; other site 983545012556 Molecular Tunnel; other site 983545012557 heavy metal efflux pump (cobalt-zinc-cadmium); Region: 2A0601; TIGR00914 983545012558 Biotin carboxyl carrier protein [Lipid metabolism]; Region: AccB; COG0511 983545012559 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 983545012560 carboxyltransferase (CT) interaction site; other site 983545012561 biotinylation site [posttranslational modification]; other site 983545012562 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 983545012563 Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538 983545012564 Cation efflux family; Region: Cation_efflux; cl00316 983545012565 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 983545012566 Protein of unknown function (DUF3703); Region: DUF3703; pfam12487 983545012567 Cation efflux family; Region: Cation_efflux; cl00316 983545012568 Cd(II)/Pb(II)-responsive transcriptional regulator; Region: CadR-PbrR; TIGR02047 983545012569 Helix-Turn-Helix DNA binding domain of the CadR and PbrR transcription regulators; Region: HTH_CadR-PbrR; cd04784 983545012570 DNA binding residues [nucleotide binding] 983545012571 dimer interface [polypeptide binding]; other site 983545012572 putative metal binding site [ion binding]; other site 983545012573 hypothetical protein; Provisional; Region: PRK09272 983545012574 Helix-turn-helix domains; Region: HTH; cl00088 983545012575 Peptidase family M48; Region: Peptidase_M48; cl12018 983545012576 Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538 983545012577 Negative regulator of genetic competence (MecA); Region: MecA; cl02022 983545012578 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 983545012579 E3 interaction surface; other site 983545012580 lipoyl attachment site [posttranslational modification]; other site 983545012581 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 983545012582 heavy metal efflux pump (cobalt-zinc-cadmium); Region: 2A0601; TIGR00914 983545012583 HupE / UreJ protein; Region: HupE_UreJ; cl01011 983545012584 TonB-dependent receptor; Region: TonB-Xanth-Caul; TIGR01782 983545012585 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl00284 983545012586 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl00284 983545012587 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 983545012588 DNA binding site [nucleotide binding] 983545012589 Periplasmic component of the Tol biopolymer transport system [Intracellular trafficking and secretion]; Region: TolB; COG0823 983545012590 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 983545012591 Periplasmic component of the Tol biopolymer transport system [Intracellular trafficking and secretion]; Region: TolB; COG0823 983545012592 translocation protein TolB; Provisional; Region: tolB; PRK04792 983545012593 PepSY-associated TM helix; Region: PepSY_TM_2; cl15813 983545012594 PepSY-associated TM helix; Region: PepSY_TM_2; cl15813 983545012595 Na(+)-translocating NADH-quinone reductase subunit F; Provisional; Region: PRK05464 983545012596 Na+-translocating NADH:quinone oxidoreductase (Na+-NQR) FAD/NADH binding domain. (Na+-NQR) provides a means of storing redox reaction energy via the transmembrane translocation of Na2+ ions. The C-terminal domain resembles ferredoxin:NADP+ oxidoreductase; Region: NADH_quinone_reductase; cd06188 983545012597 FAD binding pocket [chemical binding]; other site 983545012598 FAD binding motif [chemical binding]; other site 983545012599 phosphate binding motif [ion binding]; other site 983545012600 beta-alpha-beta structure motif; other site 983545012601 NAD binding pocket [chemical binding]; other site 983545012602 DNA-binding transcriptional activator CusR; Provisional; Region: PRK09836 983545012603 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 983545012604 active site 983545012605 phosphorylation site [posttranslational modification] 983545012606 intermolecular recognition site; other site 983545012607 dimerization interface [polypeptide binding]; other site 983545012608 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 983545012609 DNA binding site [nucleotide binding] 983545012610 copper-resistance protein, CopA family; Region: copper_res_A; TIGR01480 983545012611 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; cl11412 983545012612 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; cl11412 983545012613 Copper resistance protein B precursor (CopB); Region: CopB; cl01476 983545012614 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; cl11412 983545012615 Copper resistance protein B precursor (CopB); Region: CopB; cl01476 983545012616 Bacterial Ig-like domain; Region: Big_5; cl01012 983545012617 Copper resistance protein D; Region: CopD; cl00563 983545012618 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 983545012619 Domain of unknown function (DUF305); Region: DUF305; cl15795 983545012620 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 983545012621 heavy metal efflux pump (cobalt-zinc-cadmium); Region: 2A0601; TIGR00914 983545012622 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 983545012623 carboxyltransferase (CT) interaction site; other site 983545012624 biotinylation site [posttranslational modification]; other site 983545012625 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 983545012626 Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538 983545012627 Cation efflux family; Region: Cation_efflux; cl00316 983545012628 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 983545012629 Protein of unknown function (DUF3703); Region: DUF3703; pfam12487 983545012630 Cation efflux family; Region: Cation_efflux; cl00316 983545012631 Cd(II)/Pb(II)-responsive transcriptional regulator; Region: CadR-PbrR; TIGR02047 983545012632 Helix-Turn-Helix DNA binding domain of the CadR and PbrR transcription regulators; Region: HTH_CadR-PbrR; cd04784 983545012633 DNA binding residues [nucleotide binding] 983545012634 dimer interface [polypeptide binding]; other site 983545012635 putative metal binding site [ion binding]; other site 983545012636 dolichyl-phosphate beta-D-mannosyltransferase; Region: PLN02726 983545012637 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 983545012638 Ligand binding site; other site 983545012639 Putative Catalytic site; other site 983545012640 DXD motif; other site 983545012641 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 983545012642 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 983545012643 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl15769 983545012644 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 983545012645 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 983545012646 active site residue [active] 983545012647 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 983545012648 active site residue [active] 983545012649 Sulphur transport; Region: Sulf_transp; cl01018 983545012650 sensor protein QseC; Provisional; Region: PRK10337 983545012651 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 983545012652 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 983545012653 dimer interface [polypeptide binding]; other site 983545012654 phosphorylation site [posttranslational modification] 983545012655 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 983545012656 ATP binding site [chemical binding]; other site 983545012657 Mg2+ binding site [ion binding]; other site 983545012658 G-X-G motif; other site 983545012659 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 983545012660 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 983545012661 active site 983545012662 phosphorylation site [posttranslational modification] 983545012663 intermolecular recognition site; other site 983545012664 dimerization interface [polypeptide binding]; other site 983545012665 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 983545012666 DNA binding site [nucleotide binding] 983545012667 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 983545012668 catalytic residues [active] 983545012669 disulfide isomerase/thiol-disulfide oxidase; Provisional; Region: dsbG; PRK11657 983545012670 DsbA family, DsbC and DsbG subfamily; V-shaped homodimeric proteins containing a redox active CXXC motif imbedded in a TRX fold. They function as protein disulfide isomerases and chaperones in the bacterial periplasm to correct non-native disulfide bonds...; Region: DsbA_DsbC_DsbG; cd03020 983545012671 dimerization domain [polypeptide binding]; other site 983545012672 dimer interface [polypeptide binding]; other site 983545012673 catalytic residues [active] 983545012674 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 983545012675 multidrug efflux system transporter AcrA; Provisional; Region: PRK15030 983545012676 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 983545012677 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 983545012678 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 983545012679 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 983545012680 Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr; Region: PTPc; cl00053 983545012681 Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446 983545012682 copper-resistance protein, CopA family; Region: copper_res_A; TIGR01480 983545012683 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; cl11412 983545012684 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; cl11412 983545012685 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; cl11412 983545012686 Copper resistance protein B precursor (CopB); Region: CopB; cl01476 983545012687 Domain of unknown function (DUF305); Region: DUF305; cl15795 983545012688 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 983545012689 Phospholipid methyltransferase; Region: PEMT; cl00763 983545012690 Protein of unknown function (DUF2933); Region: DUF2933; pfam11666 983545012691 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; cl11412 983545012692 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 983545012693 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 983545012694 metal-binding site [ion binding] 983545012695 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 983545012696 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 983545012697 Helix-Turn-Helix DNA binding domain of putative Heavy Metal Resistance transcription regulators; Region: HTH_HMRTR_unk; cd04787 983545012698 Hg(II)-responsive transcriptional regulator; Region: MerR; TIGR02051 983545012699 DNA binding residues [nucleotide binding] 983545012700 dimer interface [polypeptide binding]; other site 983545012701 HypE (Hydrogenase expression/formation protein). HypE is involved in Ni-Fe hydrogenase biosynthesis. HypE dehydrates its own carbamoyl moiety in an ATP-dependent process to yield the enzyme thiocyanate. The N-terminal domain of HypE is related to the...; Region: HypE; cd02197 983545012702 dimerization interface [polypeptide binding]; other site 983545012703 hydrogenase expression/formation protein HypE; Region: hypE; TIGR02124 983545012704 ATP binding site [chemical binding]; other site 983545012705 Acylphosphatase; Region: Acylphosphatase; cl00551 983545012706 Hydrogenase maturation factor [Posttranslational modification, protein turnover, chaperones]; Region: HypF; COG0068 983545012707 HypF finger; Region: zf-HYPF; pfam07503 983545012708 HypF finger; Region: zf-HYPF; pfam07503 983545012709 Telomere recombination; Region: Sua5_yciO_yrdC; cl00305 983545012710 Hydrogenase formation hypA family; Region: HypD; cl12072 983545012711 Hydrogenase maturation factor [Posttranslational modification, protein turnover, chaperones]; Region: HypD; COG0409 983545012712 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 983545012713 Hydrogenase expression/synthesis hypA family; Region: HypA; pfam01155 983545012714 hydrogenase nickel incorporation protein; Provisional; Region: hypA; cl00418 983545012715 HupF/HypC family; Region: HupF_HypC; cl00394 983545012716 Nickel-dependent hydrogenase; Region: NiFeSe_Hases; cl00417 983545012717 Ni,Fe-hydrogenase I small subunit [Energy production and conversion]; Region: HyaA; COG1740 983545012718 NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; cl15792 983545012719 HupH hydrogenase expression protein, C-terminal conserved region; Region: HupH_C; pfam04809 983545012720 Endopeptidases belonging to membrane-bound hydrogenases group. These hydrogenases transfer electrons from H2 to a cytochrome that is bound to a membrane-located complex coupling electron transfer to transmembrane proton translocation. Endopeptidase HybD...; Region: H2MP_MemB-H2up; cd06062 983545012721 putative substrate-binding site; other site 983545012722 nickel binding site [ion binding]; other site 983545012723 Heme-binding domain of the class III cytochrome C family and related proteins; Region: Cytochrom_C3; cd08168 983545012724 heme-binding residues [chemical binding]; other site 983545012725 Iron-sulfur binding ferredoxin reductase (FNR) proteins combine the FAD and NAD(P) binding regions of FNR with an iron-sulfur binding cluster domain. Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron...; Region: FNR_iron_sulfur_binding_3; cd06217 983545012726 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 983545012727 FAD binding pocket [chemical binding]; other site 983545012728 FAD binding motif [chemical binding]; other site 983545012729 phosphate binding motif [ion binding]; other site 983545012730 beta-alpha-beta structure motif; other site 983545012731 NAD binding pocket [chemical binding]; other site 983545012732 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 983545012733 catalytic loop [active] 983545012734 iron binding site [ion binding]; other site 983545012735 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 983545012736 Cytochrome c; Region: Cytochrom_C; cl11414 983545012737 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 983545012738 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 983545012739 NAD(P) binding site [chemical binding]; other site 983545012740 active site 983545012741 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 983545012742 FAD binding domain; Region: FAD_binding_4; pfam01565 983545012743 Protein of unknown function (DUF1624); Region: DUF1624; cl01394 983545012744 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 983545012745 Copper resistance protein D; Region: CopD; cl00563 983545012746 Bacterial Ig-like domain; Region: Big_5; cl01012 983545012747 Na+-transporting NADH:ubiquinone oxidoreductase, subunit NqrF [Energy production and conversion]; Region: NqrF; COG2871 983545012748 Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron transport...; Region: FNR_like; cl06868 983545012749 FAD binding pocket [chemical binding]; other site 983545012750 conserved FAD binding motif [chemical binding]; other site 983545012751 phosphate binding motif [ion binding]; other site 983545012752 beta-alpha-beta structure motif; other site 983545012753 NAD binding pocket [chemical binding]; other site 983545012754 PepSY-associated TM helix; Region: PepSY_TM_2; cl15813 983545012755 Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696 983545012756 copper/silver efflux system membrane fusion protein CusB; Provisional; Region: PRK09783 983545012757 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 983545012758 Copper binding periplasmic protein CusF; Region: CusF_Ec; cl02363 983545012759 Copper binding periplasmic protein CusF; Region: CusF_Ec; cl02363 983545012760 Copper binding periplasmic protein CusF; Region: CusF_Ec; cl02363 983545012761 Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538 983545012762 Protein of unknown function, DUF; Region: DUF411; cl01142 983545012763 heavy metal response regulator; Region: cztR_silR_copR; TIGR01387 983545012764 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 983545012765 active site 983545012766 phosphorylation site [posttranslational modification] 983545012767 intermolecular recognition site; other site 983545012768 dimerization interface [polypeptide binding]; other site 983545012769 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 983545012770 DNA binding site [nucleotide binding] 983545012771 sensor kinase CusS; Provisional; Region: PRK09835 983545012772 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 983545012773 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 983545012774 dimer interface [polypeptide binding]; other site 983545012775 phosphorylation site [posttranslational modification] 983545012776 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 983545012777 ATP binding site [chemical binding]; other site 983545012778 Mg2+ binding site [ion binding]; other site 983545012779 G-X-G motif; other site 983545012780 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 983545012781 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 983545012782 active site 983545012783 phosphorylation site [posttranslational modification] 983545012784 intermolecular recognition site; other site 983545012785 dimerization interface [polypeptide binding]; other site 983545012786 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 983545012787 DNA binding site [nucleotide binding] 983545012788 sensor protein QseC; Provisional; Region: PRK10337 983545012789 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 983545012790 dimer interface [polypeptide binding]; other site 983545012791 phosphorylation site [posttranslational modification] 983545012792 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 983545012793 ATP binding site [chemical binding]; other site 983545012794 Mg2+ binding site [ion binding]; other site 983545012795 G-X-G motif; other site 983545012796 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3328 983545012797 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; cl14891 983545012798 Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007 983545012799 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; cl14891 983545012800 Integrase core domain; Region: rve; cl01316 983545012801 IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817 983545012802 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474 983545012803 active site 983545012804 lipid A phosphoethanolamine transferase; Reviewed; Region: PRK09598 983545012805 Domain of unknown function (DUF1705); Region: DUF1705; pfam08019 983545012806 Sulfatase; Region: Sulfatase; cl10460 983545012807 Protein of unknown function (DUF3108); Region: DUF3108; pfam11306 983545012808 Hemolysin activation/secretion protein [Intracellular trafficking and secretion]; Region: FhaC; COG2831 983545012809 putative metal dependent hydrolase; Provisional; Region: PRK11598 983545012810 Domain of unknown function (DUF1705); Region: DUF1705; pfam08019 983545012811 Sulfatase; Region: Sulfatase; cl10460 983545012812 Prokaryotic diacylglycerol kinase; Region: DAGK_prokar; cl00526 983545012813 Helix-turn-helix domains; Region: HTH; cl00088 983545012814 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368 983545012815 Sulfatase; Region: Sulfatase; cl10460 983545012816 putative transposase OrfB; Reviewed; Region: PHA02517 983545012817 HTH-like domain; Region: HTH_21; pfam13276 983545012818 Integrase core domain; Region: rve; cl01316 983545012819 Integrase core domain; Region: rve_3; cl15866 983545012820 Helix-turn-helix domains; Region: HTH; cl00088 983545012821 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 983545012822 HipA N-terminal domain; Region: Couple_hipA; cl11853 983545012823 HipA-like N-terminal domain; Region: HipA_N; pfam07805 983545012824 HipA-like C-terminal domain; Region: HipA_C; pfam07804 983545012825 DNA replication terminus site-binding protein (Ter protein); Region: Ter; cl11502 983545012826 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 983545012827 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 983545012828 Family description; Region: UvrD_C_2; cl15862 983545012829 Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which...; Region: ZnMc; cl00064 983545012830 Calx-beta domain; Region: Calx-beta; cl02522 983545012831 Calx-beta domain; Region: Calx-beta; cl02522 983545012832 Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which...; Region: ZnMc; cl00064 983545012833 Calx-beta domain; Region: Calx-beta; cl02522 983545012834 Calx-beta domain; Region: Calx-beta; cl02522 983545012835 Bacterial protein of unknown function (DUF945); Region: DUF945; pfam06097 983545012836 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; cl06830 983545012837 general secretion pathway protein G; Region: typeII_sec_gspG; TIGR01710 983545012838 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; cl06830 983545012839 Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulG; COG2165 983545012840 Protein of unknown function (DUF993); Region: DUF993; pfam06187 983545012841 Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459 983545012842 pilus retraction protein PilT; Region: pilT_fam; TIGR01420 983545012843 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 983545012844 Walker A motif; other site 983545012845 ATP binding site [chemical binding]; other site 983545012846 Walker B motif; other site 983545012847 type IVB pilus formation outer membrane protein, R64 PilN family; Region: pilus_B_mal_scr; TIGR02520 983545012848 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 983545012849 Putative exonuclease, RdgC; Region: RdgC; cl01122 983545012850 Staphylococcal nuclease homologues; Region: SNc; smart00318 983545012851 Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cl00140 983545012852 Catalytic site; other site 983545012853 DNA/RNA non-specific endonuclease; Region: Endonuclease_NS; smart00892 983545012854 DNA/RNA non-specific endonuclease; prokaryotic and eukaryotic double- and single-stranded DNA and RNA endonucleases also present in phosphodiesterases. They exists as monomers and homodimers; Region: NUC; cl00089 983545012855 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 983545012856 metal binding site [ion binding]; metal-binding site 983545012857 active site 983545012858 I-site; other site 983545012859 HipA-like C-terminal domain; Region: HipA_C; pfam07804 983545012860 probable DNA repair protein; Region: TIGR03623 983545012861 Inactivated superfamily I helicase [DNA replication, recombination, and repair]; Region: COG3893 983545012862 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641 983545012863 OpgC protein; Region: OpgC_C; cl00792 983545012864 ATP-dependent exoDNAse (exonuclease V) beta subunit (contains helicase and exonuclease domains) [DNA replication, recombination, and repair]; Region: RecB; COG1074 983545012865 Family description; Region: UvrD_C_2; cl15862 983545012866 plasmid-partitioning protein; Provisional; Region: PRK13698 983545012867 plasmid partitioning protein RepA; Region: partition_RepA; TIGR03453 983545012868 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 983545012869 P-loop; other site 983545012870 Magnesium ion binding site [ion binding]; other site 983545012871 PRTRC system ParB family protein; Region: PRTRC_parB; TIGR03734 983545012872 ParB-like nuclease domain; Region: ParBc; cl02129 983545012873 Prokaryotic E2 family D; Region: Prok-E2_D; cl14019 983545012874 PRTRC system ThiF family protein; Region: PRTRC_ThiF; TIGR03736 983545012875 Superfamily of activating enzymes (E1) of the ubiquitin-like proteins. This family includes classical ubiquitin-activating enzymes E1, ubiquitin-like (ubl) activating enzymes and other mechanistic homologes, like MoeB, Thif1 and others. The common...; Region: E1_enzyme_family; cd01483 983545012876 ATP binding site [chemical binding]; other site 983545012877 substrate interface [chemical binding]; other site