-- dump date 20120504_145316 -- class Genbank::misc_feature -- table misc_feature_note -- id note 251221000001 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_20; cd07254 251221000002 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 251221000003 putative metal binding site [ion binding]; other site 251221000004 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 251221000005 putative DNA binding site [nucleotide binding]; other site 251221000006 dimerization interface [polypeptide binding]; other site 251221000007 putative Zn2+ binding site [ion binding]; other site 251221000008 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333 251221000009 amphipathic channel; other site 251221000010 Asn-Pro-Ala signature motifs; other site 251221000011 Low molecular weight phosphatase family; Region: LMWPc; cd00115 251221000012 Low molecular weight phosphotyrosine protein phosphatase; Region: LMWPc; pfam01451 251221000013 active site 251221000014 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 251221000015 Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr; Region: PTPc; cl00053 251221000016 active site 251221000017 catalytic residues [active] 251221000018 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 251221000019 dimerization interface [polypeptide binding]; other site 251221000020 putative DNA binding site [nucleotide binding]; other site 251221000021 putative Zn2+ binding site [ion binding]; other site 251221000022 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 251221000023 phosphate ABC transporter, permease protein PstC; Region: phosphate_pstC; TIGR02138 251221000024 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 251221000025 dimer interface [polypeptide binding]; other site 251221000026 conserved gate region; other site 251221000027 putative PBP binding loops; other site 251221000028 ABC-ATPase subunit interface; other site 251221000029 phosphate ABC transporter, permease protein PstA; Region: 3a0107s02c; TIGR00974 251221000030 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 251221000031 dimer interface [polypeptide binding]; other site 251221000032 conserved gate region; other site 251221000033 putative PBP binding loops; other site 251221000034 ABC-ATPase subunit interface; other site 251221000035 phosphate ABC transporter ATP-binding protein; Provisional; Region: PRK14252 251221000036 Phosphate uptake is of fundamental importance in the cell physiology of bacteria because phosphate is required as a nutrient. The Pst system of E. coli comprises four distinct subunits encoded by the pstS, pstA, pstB, and pstC genes. The PstS protein...; Region: ABC_PstB_phosphate_transporter; cd03260 251221000037 Walker A/P-loop; other site 251221000038 ATP binding site [chemical binding]; other site 251221000039 Q-loop/lid; other site 251221000040 ABC transporter signature motif; other site 251221000041 Walker B; other site 251221000042 D-loop; other site 251221000043 H-loop/switch region; other site 251221000044 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 251221000045 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 251221000046 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 251221000047 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 251221000048 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 251221000049 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 251221000050 putative active site pocket [active] 251221000051 dimerization interface [polypeptide binding]; other site 251221000052 putative catalytic residue [active] 251221000053 Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538 251221000054 type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843 251221000055 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 251221000056 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 251221000057 E3 interaction surface; other site 251221000058 lipoyl attachment site [posttranslational modification]; other site 251221000059 ABC-type bacteriocin/lantibiotic exporters, contain an N-terminal double-glycine peptidase domain [Defense mechanisms]; Region: SunT; COG2274 251221000060 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 251221000061 Walker A/P-loop; other site 251221000062 ATP binding site [chemical binding]; other site 251221000063 Q-loop/lid; other site 251221000064 ABC transporter signature motif; other site 251221000065 Walker B; other site 251221000066 D-loop; other site 251221000067 H-loop/switch region; other site 251221000068 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 251221000069 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 251221000070 active site 251221000071 phosphorylation site [posttranslational modification] 251221000072 intermolecular recognition site; other site 251221000073 dimerization interface [polypeptide binding]; other site 251221000074 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 251221000075 DNA binding site [nucleotide binding] 251221000076 heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386 251221000077 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 251221000078 dimerization interface [polypeptide binding]; other site 251221000079 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 251221000080 dimer interface [polypeptide binding]; other site 251221000081 phosphorylation site [posttranslational modification] 251221000082 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 251221000083 ATP binding site [chemical binding]; other site 251221000084 Mg2+ binding site [ion binding]; other site 251221000085 G-X-G motif; other site 251221000086 primosome assembly protein PriA; Validated; Region: PRK05580 251221000087 primosome assembly protein PriA; Validated; Region: PRK05580 251221000088 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 251221000089 ATP binding site [chemical binding]; other site 251221000090 putative Mg++ binding site [ion binding]; other site 251221000091 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 251221000092 nucleotide binding region [chemical binding]; other site 251221000093 ATP-binding site [chemical binding]; other site 251221000094 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 251221000095 iron-sulfur cluster [ion binding]; other site 251221000096 [2Fe-2S] cluster binding site [ion binding]; other site 251221000097 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 251221000098 hydrophobic ligand binding site; other site 251221000099 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812 251221000100 hydrophobic ligand binding site; other site 251221000101 Peroxiredoxin (PRX)-like 2 family; hypothetical proteins that show sequence similarity to PRXs. Members of this group contain a CXXC motif, similar to TRX. The second cysteine in the motif corresponds to the peroxidatic cysteine of PRX, however, these...; Region: PRX_like2; cd02970 251221000102 putative catalytic residues [active] 251221000103 RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398 251221000104 tetramer (dimer of dimers) interface [polypeptide binding]; other site 251221000105 active site 251221000106 dimer interface [polypeptide binding]; other site 251221000107 Tetrapyrrole (Corrin/Porphyrin) Methylases; Region: TP_methylase; cl00304 251221000108 PAS fold; Region: PAS_4; pfam08448 251221000109 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 251221000110 dimer interface [polypeptide binding]; other site 251221000111 phosphorylation site [posttranslational modification] 251221000112 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 251221000113 ATP binding site [chemical binding]; other site 251221000114 Mg2+ binding site [ion binding]; other site 251221000115 G-X-G motif; other site 251221000116 Response regulator receiver domain; Region: Response_reg; pfam00072 251221000117 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 251221000118 active site 251221000119 phosphorylation site [posttranslational modification] 251221000120 intermolecular recognition site; other site 251221000121 dimerization interface [polypeptide binding]; other site 251221000122 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 251221000123 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 251221000124 Walker A motif; other site 251221000125 Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein; Region: Hint; cd00081 251221000126 thioester formation/cholesterol transfer; other site 251221000127 protein-splicing catalytic site; other site 251221000128 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cl14780 251221000129 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 251221000130 ATP binding site [chemical binding]; other site 251221000131 Walker B motif; other site 251221000132 DNA binding loops [nucleotide binding] 251221000133 Ntn-hydrolase superfamily, L-Asparaginase type 2-like enzymes. This family includes Glycosylasparaginase, Taspase 1 and L-Asparaginase type 2 enzymes. Glycosylasparaginase catalyzes the hydrolysis of the glycosylamide bond of asparagine-linked...; Region: Ntn_Asparaginase_2_like; cl00635 251221000134 active site 251221000135 dimer interface [polypeptide binding]; other site 251221000136 catalytic nucleophile [active] 251221000137 Protein of unknown function (DUF419); Region: DUF419; cl15265 251221000138 TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056 251221000139 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 251221000140 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 251221000141 putative active site [active] 251221000142 CsbD-like; Region: CsbD; cl01888 251221000143 single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644 251221000144 DHH family; Region: DHH; pfam01368 251221000145 DHHA1 domain; Region: DHHA1; pfam02272 251221000146 adenylosuccinate lyase; Provisional; Region: PRK07380 251221000147 Adenylsuccinate lyase (ASL)_subgroup 1; Region: Adenylsuccinate_lyase_1; cd01360 251221000148 tetramer interface [polypeptide binding]; other site 251221000149 active site 251221000150 Lyase class I_like superfamily: contains the lyase class I family, histidine ammonia-lyase and phenylalanine ammonia-lyase, which catalyze similar beta-elimination reactions; Region: Lyase_I_like; cl00013 251221000151 Family description; Region: VCBS; pfam13517 251221000152 Family description; Region: VCBS; pfam13517 251221000153 Family description; Region: VCBS; pfam13517 251221000154 Family description; Region: VCBS; pfam13517 251221000155 Uncharacterized family 1; belongs to a superfamily containing the transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this family was previously known as part of DUF156; Region: CsoR-like_DUF156_1; cd10158 251221000156 putative homotetramer interface [polypeptide binding]; other site 251221000157 putative homodimer interface [polypeptide binding]; other site 251221000158 putative metal binding site [ion binding]; other site 251221000159 putative homodimer-homodimer interface [polypeptide binding]; other site 251221000160 putative allosteric switch controlling residues; other site 251221000161 Orange carotenoid protein, N-terminal; Region: Carot_N; pfam09150 251221000162 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 251221000163 ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668 251221000164 ABC-2 type transporter; Region: ABC2_membrane; cl11417 251221000165 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 251221000166 NatA is the ATPase component of a bacterial ABC-type Na+ transport system called NatAB, which catalyzes ATP-dependent electrogenic Na+ extrusion without mechanically coupled proton or K+ uptake. NatB possess six putative membrane spanning regions at its...; Region: ABC_NatA_sodium_exporter; cd03266 251221000167 Walker A/P-loop; other site 251221000168 ATP binding site [chemical binding]; other site 251221000169 Q-loop/lid; other site 251221000170 ABC transporter signature motif; other site 251221000171 Walker B; other site 251221000172 D-loop; other site 251221000173 H-loop/switch region; other site 251221000174 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 251221000175 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 251221000176 Catalytic domain of Protein Kinases; Region: PKc; cd00180 251221000177 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 251221000178 active site 251221000179 substrate binding site [chemical binding]; other site 251221000180 ATP binding site [chemical binding]; other site 251221000181 activation loop (A-loop); other site 251221000182 Signal transduction histidine kinase, nitrate/nitrite-specific [Signal transduction mechanisms]; Region: NarQ; COG3850 251221000183 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 251221000184 dimerization interface [polypeptide binding]; other site 251221000185 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 251221000186 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 251221000187 putative active site [active] 251221000188 heme pocket [chemical binding]; other site 251221000189 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 251221000190 dimer interface [polypeptide binding]; other site 251221000191 phosphorylation site [posttranslational modification] 251221000192 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 251221000193 ATP binding site [chemical binding]; other site 251221000194 Mg2+ binding site [ion binding]; other site 251221000195 G-X-G motif; other site 251221000196 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 251221000197 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 251221000198 active site 251221000199 metal binding site [ion binding]; metal-binding site 251221000200 Nucleotidyl transferase of unknown function (DUF1814); Region: DUF1814; cl00973 251221000201 Dockerin type I repeat; Region: Dockerin_1; pfam00404 251221000202 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl15700 251221000203 Dockerin type I repeat; Region: Dockerin_1; pfam00404 251221000204 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl15700 251221000205 Dockerin type I repeat; Region: Dockerin_1; pfam00404 251221000206 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 251221000207 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl09944 251221000208 active site 251221000209 phosphorylation site [posttranslational modification] 251221000210 intermolecular recognition site; other site 251221000211 dimerization interface [polypeptide binding]; other site 251221000212 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 251221000213 DNA binding residues [nucleotide binding] 251221000214 Phosphoribosyl transferase domain; Region: Pribosyltran; cl00309 251221000215 Protein of unknown function (DUF3155); Region: DUF3155; pfam11352 251221000216 DNA polymerase III subunit delta; Validated; Region: PRK07452 251221000217 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 251221000218 carboxyl-terminal processing protease; Provisional; Region: PLN00049 251221000219 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 251221000220 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 251221000221 protein binding site [polypeptide binding]; other site 251221000222 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 251221000223 Catalytic dyad [active] 251221000224 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cl00086 251221000225 gamma-glutamyl kinase; Provisional; Region: PRK05429 251221000226 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 251221000227 nucleotide binding site [chemical binding]; other site 251221000228 homotetrameric interface [polypeptide binding]; other site 251221000229 putative phosphate binding site [ion binding]; other site 251221000230 putative allosteric binding site; other site 251221000231 PUA domain; Region: PUA; cl00607 251221000232 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062 251221000233 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 251221000234 inhibitor-cofactor binding pocket; inhibition site 251221000235 pyridoxal 5'-phosphate binding site [chemical binding]; other site 251221000236 catalytic residue [active] 251221000237 Signal peptidase (SPase) II; Region: Peptidase_A8; cl00458 251221000238 lipoprotein signal peptidase; Provisional; Region: PRK14787 251221000239 pseudouridine synthase, RluA family; Region: rluA_subfam; TIGR00005 251221000240 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 251221000241 RNA binding surface [nucleotide binding]; other site 251221000242 PseudoU_synth_RsuA/RluD: Pseudouridine synthase, RsuA/RluD family. This group is comprised of eukaryotic, bacterial and archeal proteins similar to eight site specific Escherichia coli pseudouridine synthases: RsuA, RluA, RluB, RluC, RluD, RluE, RluF and...; Region: PseudoU_synth_RluCD_like; cd02869 251221000243 active site 251221000244 DNA/RNA non-specific endonuclease; prokaryotic and eukaryotic double- and single-stranded DNA and RNA endonucleases also present in phosphodiesterases. They exists as monomers and homodimers; Region: NUC; cd00091 251221000245 DNA/RNA non-specific endonuclease; Region: Endonuclease_NS; smart00892 251221000246 active site 251221000247 substrate binding site [chemical binding]; other site 251221000248 Mg2+ binding site [ion binding]; other site 251221000249 Helix-turn-helix domains; Region: HTH; cl00088 251221000250 putative transposase OrfB; Reviewed; Region: PHA02517 251221000251 Integrase core domain; Region: rve; cl01316 251221000252 Ycf4; Region: Ycf4; cl03567 251221000253 Alpha-mannosidase [Carbohydrate transport and metabolism]; Region: AMS1; COG0383 251221000254 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 251221000255 Glycosyl hydrolases family 38 N-terminal domain; Region: Glyco_hydro_38; pfam01074 251221000256 Alpha mannosidase, middle domain; Region: Alpha-mann_mid; cl08536 251221000257 Rhomboid family; Region: Rhomboid; cl11446 251221000258 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 251221000259 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 251221000260 H+ Antiporter protein; Region: 2A0121; TIGR00900 251221000261 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 251221000262 putative substrate translocation pore; other site 251221000263 DNA repair protein RecO; Region: reco; TIGR00613 251221000264 Ribosomal protein L3; Region: Ribosomal_L3; cl00324 251221000265 Ribosomal protein L4/L1 family; Region: Ribosomal_L4; cl00325 251221000266 Ribosomal protein L23; Region: Ribosomal_L23; cl00326 251221000267 BON domain; Region: BON; cl02771 251221000268 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 251221000269 TonB-dependent heme/hemoglobin receptor family protein; Region: TonB-hemin; TIGR01785 251221000270 Aminopeptidase P, N-terminal domain; Region: AMP_N; cl08433 251221000271 Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on...; Region: Prolidase; cd01087 251221000272 active site 251221000273 Caspase, interleukin-1 beta converting enzyme (ICE) homologues; Cysteine-dependent aspartate-directed proteases that mediate programmed cell death (apoptosis). Caspases are synthesized as inactive zymogens and activated by proteolysis of the peptide...; Region: CASc; cl00042 251221000274 SpoVT / AbrB like domain; Region: SpoVT_AbrB; cl00877 251221000275 PemK-like protein; Region: PemK; cl00995 251221000276 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 251221000277 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 251221000278 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 251221000279 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 251221000280 ABC transporter; Region: ABC_tran_2; pfam12848 251221000281 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 251221000282 PAS domain S-box; Region: sensory_box; TIGR00229 251221000283 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 251221000284 putative active site [active] 251221000285 heme pocket [chemical binding]; other site 251221000286 GAF domain; Region: GAF; cl00853 251221000287 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 251221000288 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 251221000289 dimer interface [polypeptide binding]; other site 251221000290 phosphorylation site [posttranslational modification] 251221000291 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 251221000292 ATP binding site [chemical binding]; other site 251221000293 Mg2+ binding site [ion binding]; other site 251221000294 G-X-G motif; other site 251221000295 Response regulator receiver domain; Region: Response_reg; pfam00072 251221000296 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 251221000297 active site 251221000298 phosphorylation site [posttranslational modification] 251221000299 intermolecular recognition site; other site 251221000300 dimerization interface [polypeptide binding]; other site 251221000301 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: PRK02534 251221000302 GHMP kinases N terminal domain; Region: GHMP_kinases_N; cl08256 251221000303 Pyridoxine 5'-phosphate (PNP) synthase domain; pyridoxal 5'-phosphate is the active form of vitamin B6 that acts as an essential, ubiquitous coenzyme in amino acid metabolism. In bacteria, formation of pyridoxine 5'-phosphate is a step in the...; Region: PNPsynthase; cd00003 251221000304 active site 251221000305 hydrophilic channel; other site 251221000306 dimerization interface [polypeptide binding]; other site 251221000307 catalytic residues [active] 251221000308 active site lid [active] 251221000309 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 251221000310 Coenzyme A binding pocket [chemical binding]; other site 251221000311 Protein of unknown function (DUF3146); Region: DUF3146; pfam11344 251221000312 Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020 251221000313 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475 251221000314 catalytic residue [active] 251221000315 putative FPP diphosphate binding site; other site 251221000316 putative FPP binding hydrophobic cleft; other site 251221000317 dimer interface [polypeptide binding]; other site 251221000318 putative IPP diphosphate binding site; other site 251221000319 Uncharacterized conserved protein [Function unknown]; Region: COG1624 251221000320 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 251221000321 diaminopimelate decarboxylase; Region: lysA; TIGR01048 251221000322 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 251221000323 active site 251221000324 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 251221000325 substrate binding site [chemical binding]; other site 251221000326 catalytic residues [active] 251221000327 dimer interface [polypeptide binding]; other site 251221000328 ADP-ribosylglycohydrolase; Region: ADP_ribosyl_GH; cl00614 251221000329 ADP-ribosylglycohydrolase; Region: ADP_ribosyl_GH; cl00614 251221000330 classical (c) SDRs; Region: SDR_c; cd05233 251221000331 NAD(P) binding site [chemical binding]; other site 251221000332 active site 251221000333 EcsC protein family; Region: EcsC; pfam12787 251221000334 Type 1 glutamine amidotransferase (GATase1)-like domain found in cyanophycinase; Region: GAT1_cyanophycinase; cd03145 251221000335 proposed catalytic triad [active] 251221000336 active site nucleophile [active] 251221000337 Domain of unknown function (DUF4342); Region: DUF4342; pfam14242 251221000338 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 251221000339 C-terminal peptidase (prc); Region: prc; TIGR00225 251221000340 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 251221000341 protein binding site [polypeptide binding]; other site 251221000342 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 251221000343 Catalytic dyad [active] 251221000344 Uncharacterized protein family UPF0016; Region: UPF0016; pfam01169 251221000345 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Add; COG1816 251221000346 Adenosine/AMP deaminase. Adenosine deaminases (ADAs) are present in pro- and eukaryotic organisms and catalyze the zinc dependent irreversible deamination of adenosine nucleosides to inosine nucleosides and ammonia. The eukaryotic AMP deaminase...; Region: ADA_AMPD; cd00443 251221000347 active site 251221000348 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 251221000349 active site 251221000350 metal binding site [ion binding]; metal-binding site 251221000351 cobalamin biosynthesis protein CobW; Region: CobW; TIGR02475 251221000352 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 251221000353 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; cl08458 251221000354 DoxX; Region: DoxX; cl00976 251221000355 Protein of unknown function (DUF2281); Region: DUF2281; cl02355 251221000356 PemK-like protein; Region: PemK; cl00995 251221000357 Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226 251221000358 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 251221000359 S-adenosylmethionine binding site [chemical binding]; other site 251221000360 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl12011 251221000361 molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317 251221000362 MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503 251221000363 GTP binding site; other site 251221000364 Protease II [Amino acid transport and metabolism]; Region: PtrB; COG1770 251221000365 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 251221000366 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 251221000367 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 251221000368 substrate binding pocket [chemical binding]; other site 251221000369 membrane-bound complex binding site; other site 251221000370 hinge residues; other site 251221000371 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_5; cd07238 251221000372 dimer interface [polypeptide binding]; other site 251221000373 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 251221000374 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 251221000375 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 251221000376 Domain of unknown function DUF29; Region: DUF29; pfam01724 251221000377 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 251221000378 putative active site [active] 251221000379 Bacterial BAX inhibitor (BI)-1/YccA-like proteins; Region: BI-1-like_bacterial; cd10432 251221000380 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 251221000381 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 251221000382 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 251221000383 ATP cone domain; Region: ATP-cone; pfam03477 251221000384 Transposase Tn5 dimerisation domain; Region: Dimer_Tnp_Tn5; pfam02281 251221000385 Helix-turn-helix domains; Region: HTH; cl00088 251221000386 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 251221000387 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 251221000388 P-loop; other site 251221000389 Magnesium ion binding site [ion binding]; other site 251221000390 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 251221000391 Transposase domain (DUF772); Region: DUF772; cl12084 251221000392 Clp amino terminal domain; Region: Clp_N; pfam02861 251221000393 Clp amino terminal domain; Region: Clp_N; pfam02861 251221000394 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 251221000395 transaldolase/EF-hand domain-containing protein; Provisional; Region: PRK12309 251221000396 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 251221000397 active site 251221000398 acetyl-CoA synthetase; Provisional; Region: PRK00174 251221000399 Domain of unknown function (DUF3448); Region: DUF3448; pfam11930 251221000400 Acyl-protein synthetase, LuxE; Region: LuxE; cl15695 251221000401 Ribosomal protein S20; Region: Ribosomal_S20p; cl00384 251221000402 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 251221000403 Transglycosylase; Region: Transgly; cl07896 251221000404 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 251221000405 translation initiation factor Sui1; Validated; Region: PRK06824 251221000406 The SUI1/eIF1 (eukaryotic initiation factor 1) fold is found in eukaryotes, archaea, and some bacteria and is thought to play an important role in accurate initiator codon recognition during translation initiation. This fold, which includes two...; Region: SUI1_eIF1; cd00474 251221000407 Predicted RNA interaction site [nucleotide binding]; other site 251221000408 putative binding site; other site 251221000409 Mutations affecting start-site selection; other site 251221000410 Cupin domain; Region: Cupin_2; cl09118 251221000411 Plasmid stabilisation system protein; Region: Plasmid_stabil; cl11422 251221000412 Plasmid stabilisation system protein; Region: Plasmid_stabil; cl11422 251221000413 Uncharacterised protein family (UPF0156); Region: RHH_2; cl01448 251221000414 Protoheme ferro-lyase (ferrochelatase) [Coenzyme metabolism]; Region: HemH; COG0276 251221000415 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 251221000416 C-terminal domain interface [polypeptide binding]; other site 251221000417 active site 251221000418 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 251221000419 active site 251221000420 N-terminal domain interface [polypeptide binding]; other site 251221000421 The Delta12 Fatty Acid Desaturase (Delta12-FADS)-like CD includes the integral-membrane enzymes, delta-12 acyl-lipid desaturases, oleate 12-hydroxylases, omega3 and omega6 fatty acid desaturases, and other related proteins, found in a wide range of...; Region: Delta12-FADS-like; cd03507 251221000422 Fatty acid desaturase; Region: FA_desaturase; pfam00487 251221000423 putative di-iron ligands [ion binding]; other site 251221000424 FOG: Transposase [DNA replication, recombination, and repair]; Region: COG5659 251221000425 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 251221000426 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 251221000427 dimer interface [polypeptide binding]; other site 251221000428 conserved gate region; other site 251221000429 putative PBP binding loops; other site 251221000430 ABC-ATPase subunit interface; other site 251221000431 nitrate transport ATP-binding subunits C and D; Region: ntrCD; TIGR01184 251221000432 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 251221000433 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl15260 251221000434 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506 251221000435 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 251221000436 structural tetrad; other site 251221000437 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 251221000438 Retron-type reverse transcriptase [DNA replication, recombination, and repair]; Region: COG3344 251221000439 RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651 251221000440 putative active site [active] 251221000441 putative NTP binding site [chemical binding]; other site 251221000442 putative nucleic acid binding site [nucleotide binding]; other site 251221000443 Group II intron, maturase-specific domain; Region: GIIM; pfam08388 251221000444 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 251221000445 active site 251221000446 conserved hypothetical protein; Region: TIGR02466 251221000447 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; cl11412 251221000448 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657 251221000449 dinuclear metal binding motif [ion binding]; other site 251221000450 pseudouridine synthase, RluA family; Region: rluA_subfam; TIGR00005 251221000451 PseudoU_synth_RsuA/RluD: Pseudouridine synthase, RsuA/RluD family. This group is comprised of eukaryotic, bacterial and archeal proteins similar to eight site specific Escherichia coli pseudouridine synthases: RsuA, RluA, RluB, RluC, RluD, RluE, RluF and...; Region: PseudoU_synth_RluCD_like; cd02869 251221000452 active site 251221000453 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 251221000454 Helix-turn-helix domains; Region: HTH; cl00088 251221000455 Predicted oxidoreductases (related to aryl-alcohol dehydrogenases) [Energy production and conversion]; Region: Tas; COG0667 251221000456 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 251221000457 active site 251221000458 catalytic tetrad [active] 251221000459 Predominantly bacterial family of Mg++ dependend phosphatases, related to inositol monophosphatases. These enzymes may dephosphorylate fructose-1,6-bisphosphate, inositol monophospate, 3'-phosphoadenosine-5'-phosphate, or similar substrates; Region: Bacterial_IMPase_like_1; cd01641 251221000460 active site 251221000461 Quinolinate synthetase A protein; Region: NadA; cl00420 251221000462 3-deoxy-7-phosphoheptulonate synthase; Reviewed; Region: PRK08673 251221000463 NeuB family; Region: NeuB; cl00496 251221000464 1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444 251221000465 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 251221000466 TPP-binding site; other site 251221000467 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 251221000468 PYR/PP interface [polypeptide binding]; other site 251221000469 dimer interface [polypeptide binding]; other site 251221000470 TPP binding site [chemical binding]; other site 251221000471 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 251221000472 methylthioribose-1-phosphate isomerase; Reviewed; Region: mtnA; PRK05720 251221000473 Predicted translation initiation factor 2B subunit, eIF-2B alpha/beta/delta family [Translation, ribosomal structure and biogenesis]; Region: COG0182; cl00348 251221000474 AbrB-like transcriptional regulator; Region: AbrB-like; pfam14250 251221000475 Alpha-glucosidases, family 31 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: COG1501 251221000476 Alpha-glucosidase II (alpha-D-glucoside glucohydrolase) is a glycosyl hydrolase family 31 (GH31) enzyme, found in bacteria and plants, which has exo-alpha-1,4-glucosidase and oligo-1,6-glucosidase activities. Alpha-glucosidase II has been characterized...; Region: GH31_glucosidase_II_MalA; cd06604 251221000477 trimer interface [polypeptide binding]; other site 251221000478 active site 251221000479 homohexamer (dimer of homotrimer) interface [polypeptide binding]; other site 251221000480 catalytic site [active] 251221000481 Bacteriorhodopsin-like protein; Region: Bac_rhodopsin; smart01021 251221000482 Bacteriorhodopsin-like protein; Region: Bac_rhodopsin; cl02333 251221000483 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 251221000484 active site residue [active] 251221000485 Transposase; Region: DEDD_Tnp_IS110; pfam01548 251221000486 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 251221000487 RNA polymerase sigma factor, cyanobacterial RpoD-like family; Region: Sig70-cyanoRpoD; TIGR02997 251221000488 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 251221000489 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 251221000490 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 251221000491 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 251221000492 DNA binding residues [nucleotide binding] 251221000493 Domain of unknown function DUF20; Region: UPF0118; cl00465 251221000494 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cl14780 251221000495 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 251221000496 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 251221000497 Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein; Region: Hint; cd00081 251221000498 protein-splicing catalytic site; other site 251221000499 thioester formation/cholesterol transfer; other site 251221000500 Protein of unknown function (DUF1557); Region: DUF1557; pfam07591 251221000501 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 251221000502 FOG: Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3385 251221000503 Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as Transcription factor ImmunoGlobin (TIG) domains. They are present in intracellular transcription factors, cell surface receptors (such as plexins and scatter factor...; Region: IPT; cl15674 251221000504 Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein; Region: Hint; cd00081 251221000505 protein-splicing catalytic site; other site 251221000506 thioester formation/cholesterol transfer; other site 251221000507 Protein of unknown function (DUF1557); Region: DUF1557; pfam07591 251221000508 Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein; Region: Hint; cd00081 251221000509 protein-splicing catalytic site; other site 251221000510 thioester formation/cholesterol transfer; other site 251221000511 Protein of unknown function (DUF1557); Region: DUF1557; pfam07591 251221000512 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 251221000513 RHS Repeat; Region: RHS_repeat; cl11982 251221000514 RHS Repeat; Region: RHS_repeat; cl11982 251221000515 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 251221000516 Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as Transcription factor ImmunoGlobin (TIG) domains. They are present in intracellular transcription factors, cell surface receptors (such as plexins and scatter factor...; Region: IPT; cl15674 251221000517 Solibacter uncharacterized C-terminal domain; Region: Soli_cterm; TIGR03437 251221000518 Solibacter uncharacterized C-terminal domain; Region: Soli_cterm; TIGR03437 251221000519 Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein; Region: Hint; cd00081 251221000520 protein-splicing catalytic site; other site 251221000521 thioester formation/cholesterol transfer; other site 251221000522 Protein of unknown function (DUF1557); Region: DUF1557; pfam07591 251221000523 PQQ-dependent catabolism-associated beta-propeller protein; Region: PQQ_ABC_repeats; TIGR03866 251221000524 TolB amino-terminal domain; Region: TolB_N; cl00639 251221000525 photochlorophyllide reductase subunit B; Region: chlB; CHL00076 251221000526 Pchlide_reductase_B: B protein of the NB protein complex of Protochlorophyllide (Pchlide)_reductase. Pchlide reductase catalyzes the reductive formation of chlorophyllide (chlide) from protochlorophyllide (pchlide) during biosynthesis of chlorophylls and...; Region: Pchlide_reductase_B; cd01981 251221000527 Proto-chlorophyllide reductase 57 kD subunit; Region: PCP_red; pfam08369 251221000528 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 251221000529 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 251221000530 active site 251221000531 Riboflavin kinase; Region: Flavokinase; cl03312 251221000532 NAD(P)H-quinone oxidoreductase subunit F; Validated; Region: PRK07376 251221000533 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662 251221000534 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; cl14187 251221000535 NADH-Ubiquinone oxidoreductase (complex I) subunit C-terminus; Region: Oxidored_q1_C; pfam01010 251221000536 NAD(P)H-quinone oxidoreductase subunit 4; Provisional; Region: PRK02546 251221000537 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; cl14187 251221000538 RNA polymerase sigma factor, FliA/WhiG family; Region: FliA_WhiG; TIGR02479 251221000539 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 251221000540 DNA binding residues [nucleotide binding] 251221000541 Protein of unknown function (DUF1822); Region: DUF1822; pfam08852 251221000542 Response regulator receiver domain; Region: Response_reg; pfam00072 251221000543 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 251221000544 active site 251221000545 phosphorylation site [posttranslational modification] 251221000546 intermolecular recognition site; other site 251221000547 dimerization interface [polypeptide binding]; other site 251221000548 Helix-turn-helix domains; Region: HTH; cl00088 251221000549 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 251221000550 RNA binding surface [nucleotide binding]; other site 251221000551 GatB domain; Region: GatB_Yqey; cl11497 251221000552 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 251221000553 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 251221000554 Domain of unknown function (DUF4351); Region: DUF4351; pfam14261 251221000555 Predicted membrane protein [Function unknown]; Region: COG3164 251221000556 Domain of Unknown Function (DUF748); Region: DUF748; pfam05359 251221000557 AsmA family; Region: AsmA; pfam05170 251221000558 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 251221000559 active site 251221000560 Protein of unknown function (DUF2511); Region: DUF2511; pfam10709 251221000561 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 251221000562 Coenzyme A binding pocket [chemical binding]; other site 251221000563 ATPases of the AAA+ class [Posttranslational modification, protein turnover, chaperones]; Region: SpoVK; COG0464 251221000564 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 251221000565 Walker A motif; other site 251221000566 ATP binding site [chemical binding]; other site 251221000567 Walker B motif; other site 251221000568 arginine finger; other site 251221000569 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 251221000570 Walker A motif; other site 251221000571 ATP binding site [chemical binding]; other site 251221000572 Walker B motif; other site 251221000573 arginine finger; other site 251221000574 A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cd01066 251221000575 active site 251221000576 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 251221000577 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 251221000578 active site 251221000579 phosphorylation site [posttranslational modification] 251221000580 intermolecular recognition site; other site 251221000581 dimerization interface [polypeptide binding]; other site 251221000582 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 251221000583 DNA binding residues [nucleotide binding] 251221000584 dimerization interface [polypeptide binding]; other site 251221000585 Heat induced stress protein YflT; Region: YflT; pfam11181 251221000586 glycine dehydrogenase; Provisional; Region: PRK05367 251221000587 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 251221000588 tetramer interface [polypeptide binding]; other site 251221000589 pyridoxal 5'-phosphate binding site [chemical binding]; other site 251221000590 catalytic residue [active] 251221000591 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 251221000592 tetramer interface [polypeptide binding]; other site 251221000593 pyridoxal 5'-phosphate binding site [chemical binding]; other site 251221000594 catalytic residue [active] 251221000595 SpoVT / AbrB like domain; Region: SpoVT_AbrB; cl00877 251221000596 PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812 251221000597 Chaperone of endosialidase; Region: Peptidase_S74; pfam13884 251221000598 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 251221000599 SRP54-type protein, helical bundle domain; Region: SRP54_N; cl03758 251221000600 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 251221000601 P loop; other site 251221000602 GTP binding site [chemical binding]; other site 251221000603 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 251221000604 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 251221000605 motif II; other site 251221000606 BioD-like N-terminal domain of phosphotransacetylase [General function prediction only]; Region: Pta; COG0857 251221000607 DRTGG domain; Region: DRTGG; cl12147 251221000608 Nitrogen regulatory protein P-II; Region: P-II; cl00412 251221000609 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 251221000610 Orange carotenoid protein, N-terminal; Region: Carot_N; pfam09150 251221000611 Orange carotenoid protein, N-terminal; Region: Carot_N; pfam09150 251221000612 Protein of unknown function (DUF1643); Region: DUF1643; cl01787 251221000613 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 251221000614 binding surface 251221000615 TPR motif; other site 251221000616 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 251221000617 protein-(glutamine-N5) methyltransferase, release factor-specific; Region: RF_mod_PrmC; TIGR03534 251221000618 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 251221000619 non-specific DNA binding site [nucleotide binding]; other site 251221000620 salt bridge; other site 251221000621 sequence-specific DNA binding site [nucleotide binding]; other site 251221000622 Domain of unknown function (DUF955); Region: DUF955; cl01076 251221000623 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 251221000624 Major Facilitator Superfamily; Region: MFS_1; pfam07690 251221000625 putative substrate translocation pore; other site 251221000626 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 251221000627 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497 251221000628 RecN ATPase involved in DNA repair; ABC (ATP-binding cassette) transporter nucleotide-binding domain; ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds including sugars, ions, peptides, and...; Region: ABC_RecN; cd03241 251221000629 Walker A/P-loop; other site 251221000630 ATP binding site [chemical binding]; other site 251221000631 Q-loop/lid; other site 251221000632 RecN ATPase involved in DNA repair; ABC (ATP-binding cassette) transporter nucleotide-binding domain; ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds including sugars, ions, peptides, and...; Region: ABC_RecN; cd03241 251221000633 ABC transporter signature motif; other site 251221000634 Walker B; other site 251221000635 D-loop; other site 251221000636 H-loop/switch region; other site 251221000637 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 251221000638 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 251221000639 active site 251221000640 phosphorylation site [posttranslational modification] 251221000641 intermolecular recognition site; other site 251221000642 dimerization interface [polypeptide binding]; other site 251221000643 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 251221000644 DNA binding residues [nucleotide binding] 251221000645 dimerization interface [polypeptide binding]; other site 251221000646 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506 251221000647 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 251221000648 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 251221000649 PQQ-dependent catabolism-associated beta-propeller protein; Region: PQQ_ABC_repeats; TIGR03866 251221000650 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 251221000651 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 251221000652 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 251221000653 Phosphoesterase family; Region: Phosphoesterase; cl15450 251221000654 PQQ-dependent catabolism-associated beta-propeller protein; Region: PQQ_ABC_repeats; TIGR03866 251221000655 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 251221000656 Uncharacterized conserved protein [Function unknown]; Region: COG3391 251221000657 Phosphoesterase family; Region: Phosphoesterase; cl15450 251221000658 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 251221000659 Phd_YefM; Region: PhdYeFM; cl09153 251221000660 PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812 251221000661 TonB-dependent hemoglobin/transferrin/lactoferrin receptor family protein; Region: TonB-hemlactrns; TIGR01786 251221000662 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 251221000663 N-terminal plug; other site 251221000664 ligand-binding site [chemical binding]; other site 251221000665 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 251221000666 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 251221000667 active site 251221000668 phosphorylation site [posttranslational modification] 251221000669 intermolecular recognition site; other site 251221000670 dimerization interface [polypeptide binding]; other site 251221000671 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 251221000672 DNA binding site [nucleotide binding] 251221000673 heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386 251221000674 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 251221000675 dimer interface [polypeptide binding]; other site 251221000676 phosphorylation site [posttranslational modification] 251221000677 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 251221000678 ATP binding site [chemical binding]; other site 251221000679 Mg2+ binding site [ion binding]; other site 251221000680 G-X-G motif; other site 251221000681 UbiA prenyltransferase family; Region: UbiA; cl00337 251221000682 Protein of unknown function (DUF3571); Region: DUF3571; pfam12095 251221000683 tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795 251221000684 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 251221000685 binding surface 251221000686 TPR motif; other site 251221000687 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl12011 251221000688 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are 'recycled' and ready for another round of...; Region: RRF; cd00520 251221000689 ribosome recycling factor; Reviewed; Region: frr; PRK00083 251221000690 hinge region; other site 251221000691 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 251221000692 Domain I of the ABC component of a cobalt transport family found in bacteria, archaea, and eukaryota. The transition metal cobalt is an essential component of many enzymes and must be transported into cells in appropriate amounts when needed. This ABC...; Region: ABC_cobalt_CbiO_domain1; cd03225 251221000693 Walker A/P-loop; other site 251221000694 ATP binding site [chemical binding]; other site 251221000695 Q-loop/lid; other site 251221000696 ABC transporter signature motif; other site 251221000697 Walker B; other site 251221000698 D-loop; other site 251221000699 H-loop/switch region; other site 251221000700 Cobalt transport protein; Region: CbiQ; cl00463 251221000701 PDGLE domain; Region: PDGLE; cl07986 251221000702 Cobalt uptake substrate-specific transmembrane region; Region: CbiM; cl00397 251221000703 cobalt transport protein CbiM; Provisional; Region: PRK07331 251221000704 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 251221000705 Porcine testicular carbonyl reductase (PTCR)-like, classical (c) SDRs; Region: carb_red_PTCR-like_SDR_c; cd05324 251221000706 NADP binding site [chemical binding]; other site 251221000707 substrate binding site [chemical binding]; other site 251221000708 active site 251221000709 Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_2; cd03139 251221000710 conserved cys residue [active] 251221000711 GAF domain; Region: GAF; cl00853 251221000712 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 251221000713 DNA binding residues [nucleotide binding] 251221000714 dimerization interface [polypeptide binding]; other site 251221000715 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 251221000716 Coenzyme A binding pocket [chemical binding]; other site 251221000717 D-alanine--D-alanine ligase; Reviewed; Region: ddl; PRK01372 251221000718 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 251221000719 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087 251221000720 cell division protein FtsZ; Validated; Region: PRK09330 251221000721 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 251221000722 nucleotide binding site [chemical binding]; other site 251221000723 SulA interaction site; other site 251221000724 Cell division septal protein [Cell envelope biogenesis, outer membrane]; Region: FtsQ; COG1589 251221000725 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 251221000726 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 251221000727 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 251221000728 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 251221000729 N-terminal plug; other site 251221000730 ligand-binding site [chemical binding]; other site 251221000731 Secreted repeat of unknown function; Region: Lipoprotein_15; pfam03640 251221000732 Secreted repeat of unknown function; Region: Lipoprotein_15; pfam03640 251221000733 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 251221000734 putative active site [active] 251221000735 C-20 methyltransferase BchU; Region: C20_methyl_CrtF; TIGR02716 251221000736 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl12011 251221000737 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 251221000738 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cl00047 251221000739 ligand binding site [chemical binding]; other site 251221000740 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 251221000741 putative switch regulator; other site 251221000742 non-specific DNA interactions [nucleotide binding]; other site 251221000743 DNA binding site [nucleotide binding] 251221000744 sequence specific DNA binding site [nucleotide binding]; other site 251221000745 putative cAMP binding site [chemical binding]; other site 251221000746 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 251221000747 putative active site [active] 251221000748 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 251221000749 putative active site [active] 251221000750 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 251221000751 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 251221000752 N-terminal plug; other site 251221000753 ligand-binding site [chemical binding]; other site 251221000754 Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182 251221000755 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 251221000756 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 251221000757 N-terminal plug; other site 251221000758 ligand-binding site [chemical binding]; other site 251221000759 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 251221000760 Leucine carboxyl methyltransferase; Region: LCM; cl01306 251221000761 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 251221000762 putative active site [active] 251221000763 Uncharacterized conserved protein [Function unknown]; Region: COG5464 251221000764 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 251221000765 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 251221000766 N-terminal plug; other site 251221000767 ligand-binding site [chemical binding]; other site 251221000768 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 251221000769 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 251221000770 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 251221000771 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 251221000772 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 251221000773 Walker A/P-loop; other site 251221000774 ATP binding site [chemical binding]; other site 251221000775 Q-loop/lid; other site 251221000776 ABC transporter signature motif; other site 251221000777 Walker B; other site 251221000778 D-loop; other site 251221000779 H-loop/switch region; other site 251221000780 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 251221000781 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 251221000782 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 251221000783 Walker A/P-loop; other site 251221000784 ATP binding site [chemical binding]; other site 251221000785 Q-loop/lid; other site 251221000786 ABC transporter signature motif; other site 251221000787 Walker B; other site 251221000788 D-loop; other site 251221000789 H-loop/switch region; other site 251221000790 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 251221000791 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cl00047 251221000792 ligand binding site [chemical binding]; other site 251221000793 flexible hinge region; other site 251221000794 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 251221000795 putative switch regulator; other site 251221000796 non-specific DNA interactions [nucleotide binding]; other site 251221000797 DNA binding site [nucleotide binding] 251221000798 sequence specific DNA binding site [nucleotide binding]; other site 251221000799 putative cAMP binding site [chemical binding]; other site 251221000800 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 251221000801 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 251221000802 Localisation of periplasmic protein complexes; Region: AMIN; pfam11741 251221000803 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 251221000804 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 251221000805 N-terminal plug; other site 251221000806 ligand-binding site [chemical binding]; other site 251221000807 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl12011 251221000808 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 251221000809 putative active site [active] 251221000810 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 251221000811 ferrichrome outer membrane transporter; Provisional; Region: PRK10044 251221000812 Transposase, Mutator family; Region: Transposase_mut; pfam00872 251221000813 MULE transposase domain; Region: MULE; pfam10551 251221000814 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 251221000815 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 251221000816 TIGR03118 family protein; Region: PEPCTERM_chp_1 251221000817 Ferritin-like domain; Region: Ferritin; pfam00210 251221000818 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 251221000819 dimerization interface [polypeptide binding]; other site 251221000820 DPS ferroxidase diiron center [ion binding]; other site 251221000821 ion pore; other site 251221000822 Leucine carboxyl methyltransferase; Region: LCM; cl01306 251221000823 ferrichrome outer membrane transporter; Provisional; Region: PRK10044 251221000824 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 251221000825 putative active site [active] 251221000826 Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182 251221000827 Peptidase propeptide and YPEB domain; Region: PepSY; cl15480 251221000828 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 251221000829 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 251221000830 N-terminal plug; other site 251221000831 ligand-binding site [chemical binding]; other site 251221000832 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 251221000833 putative active site [active] 251221000834 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 251221000835 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 251221000836 FtsX-like permease family; Region: FtsX; pfam02687 251221000837 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 251221000838 Histidine kinase; Region: HisKA_3; pfam07730 251221000839 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 251221000840 ATP binding site [chemical binding]; other site 251221000841 Mg2+ binding site [ion binding]; other site 251221000842 G-X-G motif; other site 251221000843 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 251221000844 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 251221000845 active site 251221000846 phosphorylation site [posttranslational modification] 251221000847 intermolecular recognition site; other site 251221000848 dimerization interface [polypeptide binding]; other site 251221000849 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 251221000850 DNA binding residues [nucleotide binding] 251221000851 dimerization interface [polypeptide binding]; other site 251221000852 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 251221000853 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 251221000854 N-terminal plug; other site 251221000855 ligand-binding site [chemical binding]; other site 251221000856 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 251221000857 putative active site [active] 251221000858 transcriptional regulator NarL; Provisional; Region: PRK10651 251221000859 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 251221000860 DNA binding residues [nucleotide binding] 251221000861 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 251221000862 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 251221000863 N-terminal plug; other site 251221000864 ligand-binding site [chemical binding]; other site 251221000865 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl00284 251221000866 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 251221000867 Uncharacterised protein family (UPF0156); Region: RHH_2; cl01448 251221000868 Plasmid stabilisation system protein; Region: Plasmid_stabil; cl11422 251221000869 Domain of unknown function (DUF4351); Region: DUF4351; pfam14261 251221000870 Protein of unknown function (DUF2887); Region: DUF2887; pfam11103 251221000871 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl00284 251221000872 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 251221000873 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 251221000874 N-terminal plug; other site 251221000875 ligand-binding site [chemical binding]; other site 251221000876 Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182 251221000877 Peptidase propeptide and YPEB domain; Region: PepSY; cl15480 251221000878 PhoD-like phosphatase; Region: PhoD; pfam09423 251221000879 Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389 251221000880 putative active site [active] 251221000881 putative metal binding site [ion binding]; other site 251221000882 Protein of unknown function (DUF2808); Region: DUF2808; pfam10989 251221000883 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 251221000884 iron-sulfur cluster [ion binding]; other site 251221000885 [2Fe-2S] cluster binding site [ion binding]; other site 251221000886 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333 251221000887 amphipathic channel; other site 251221000888 Asn-Pro-Ala signature motifs; other site 251221000889 Choloylglycine hydrolase (CGH) is a bile salt-modifying enzyme that hydrolyzes non-peptide carbon-nitrogen bonds in choloylglycine and choloyltaurine, both of which are present in bile. CGH is present in a number of probiotic microbial organisms that...; Region: Ntn_CGH; cd01902 251221000890 Linear amide C-N hydrolases, choloylglycine hydrolase family; Region: CBAH; pfam02275 251221000891 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 251221000892 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl14614 251221000893 NAD(P) binding site [chemical binding]; other site 251221000894 Transposase Tn5 dimerisation domain; Region: Dimer_Tnp_Tn5; pfam02281 251221000895 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cl03075 251221000896 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 251221000897 trehalose synthase; Region: treS_nterm; TIGR02456 251221000898 active site 251221000899 catalytic site [active] 251221000900 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; cl02706 251221000901 The family 20 carbohydrate-binding module (CBM20), also known as the starch-binding domain, is found in a large number of starch degrading enzymes including alpha-amylase, beta-amylase, glucoamylase, and CGTase (cyclodextrin glucanotransferase). CBM20 is...; Region: CBM20; cd05467 251221000902 starch-binding site 2 [chemical binding]; other site 251221000903 starch-binding site 1 [chemical binding]; other site 251221000904 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 251221000905 M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886 251221000906 metal binding site [ion binding]; metal-binding site 251221000907 dimer interface [polypeptide binding]; other site 251221000908 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574 251221000909 YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300 251221000910 active site 251221000911 PAS domain S-box; Region: sensory_box; TIGR00229 251221000912 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 251221000913 putative active site [active] 251221000914 heme pocket [chemical binding]; other site 251221000915 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 251221000916 PAS fold; Region: PAS_3; pfam08447 251221000917 putative active site [active] 251221000918 heme pocket [chemical binding]; other site 251221000919 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 251221000920 dimer interface [polypeptide binding]; other site 251221000921 phosphorylation site [posttranslational modification] 251221000922 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 251221000923 ATP binding site [chemical binding]; other site 251221000924 Mg2+ binding site [ion binding]; other site 251221000925 G-X-G motif; other site 251221000926 Tetrapyrrole (Corrin/Porphyrin) Methylases; Region: TP_methylase; cl00304 251221000927 Tetrapyrrole (Corrin/Porphyrin) Methylases; Region: TP_methylase; cl00304 251221000928 Precorrin-6B methylase 2 [Coenzyme metabolism]; Region: CobL; COG2242 251221000929 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 251221000930 S-adenosylmethionine binding site [chemical binding]; other site 251221000931 phosphate regulon transcriptional regulatory protein PhoB; Region: PhoB; TIGR02154 251221000932 transcriptional regulator EpsA; Region: EpsA; TIGR03020 251221000933 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 251221000934 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 251221000935 ATP binding site [chemical binding]; other site 251221000936 Mg2+ binding site [ion binding]; other site 251221000937 G-X-G motif; other site 251221000938 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 251221000939 Domain of unknown function DUF21; Region: DUF21; pfam01595 251221000940 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 251221000941 Transporter associated domain; Region: CorC_HlyC; cl08393 251221000942 Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696 251221000943 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 251221000944 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 251221000945 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 251221000946 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 251221000947 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl15357 251221000948 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl15357 251221000949 Precorrin-8X methylmutase; Region: CbiC; pfam02570 251221000950 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 251221000951 ATP:corrinoid adenosyltransferase [Coenzyme metabolism]; Region: BtuR; COG2109 251221000952 ATP:corrinoid adenosyltransferase BtuR/CobO/CobP. This family consists of the BtuR, CobO, CobP proteins all of which are Cob(I)alamin (vitamin B12) adenosyltransferase, which is involved in cobalamin (vitamin B12) biosynthesis. This enzyme is a homodimer; Region: CobA_CobO_BtuR; cd00561 251221000953 homodimer interface [polypeptide binding]; other site 251221000954 Walker A motif; other site 251221000955 ATP binding site [chemical binding]; other site 251221000956 hydroxycobalamin binding site [chemical binding]; other site 251221000957 Walker B motif; other site 251221000958 Protein of unknown function (DUF2283); Region: DUF2283; cl02251 251221000959 haloacid dehalogenase-like hydrolase family protein; Region: PLN02919 251221000960 TlpA-like family, DipZ-like subfamily; composed uncharacterized proteins containing a TlpA-like TRX domain. Some members show domain architectures similar to that of E. coli DipZ protein (also known as DsbD). The only eukaryotic members of the TlpA...; Region: TlpA_like_DipZ_like; cd03012 251221000961 catalytic residues [active] 251221000962 This PGM-like (phosphoglucomutase-like) protein of unknown function belongs to the alpha-D-phosphohexomutase superfamily and is found in both archaea and bacteria. The alpha-D-phosphohexomutases include several related enzymes that catalyze a reversible...; Region: PGM_like2; cd05800 251221000963 Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109 251221000964 active site 251221000965 substrate binding site [chemical binding]; other site 251221000966 metal binding site [ion binding]; metal-binding site 251221000967 photosystem II S4 domain protein; Region: PS_II_S4; TIGR03069 251221000968 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 251221000969 RNA binding surface [nucleotide binding]; other site 251221000970 Dehydrogenases (flavoproteins) [Energy production and conversion]; Region: FixC; COG0644 251221000971 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 251221000972 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 251221000973 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 251221000974 7-keto-8-aminopelargonate synthetase and related enzymes [Coenzyme metabolism]; Region: BioF; COG0156 251221000975 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454 251221000976 substrate-cofactor binding pocket; other site 251221000977 pyridoxal 5'-phosphate binding site [chemical binding]; other site 251221000978 catalytic residue [active] 251221000979 Peptidase family M23; Region: Peptidase_M23; pfam01551 251221000980 50S ribosomal protein L25/general stress protein Ctc; Reviewed; Region: PRK05618 251221000981 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 251221000982 5S rRNA interface [nucleotide binding]; other site 251221000983 CTC domain interface [polypeptide binding]; other site 251221000984 L16 interface [polypeptide binding]; other site 251221000985 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 251221000986 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 251221000987 ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565 251221000988 thiS-thiF/thiG interaction site; other site 251221000989 thiamine-phosphate pyrophosphorylase; Provisional; Region: PRK02615 251221000990 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 251221000991 thiamine phosphate binding site [chemical binding]; other site 251221000992 active site 251221000993 pyrophosphate binding site [ion binding]; other site 251221000994 Protein of unknown function (DUF1565); Region: DUF1565; pfam07602 251221000995 parallel beta-helix repeat (two copies); Region: para_beta_helix; TIGR03804 251221000996 Sporulation related domain; Region: SPOR; cl10051 251221000997 Sporulation related domain; Region: SPOR; cl10051 251221000998 arogenate dehydrogenase; Reviewed; Region: PRK07417 251221000999 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 251221001000 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 251221001001 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13141 251221001002 putative active site [active] 251221001003 oxyanion strand; other site 251221001004 catalytic triad [active] 251221001005 Ferric reductase like transmembrane component; Region: Ferric_reduct; cl01043 251221001006 Heme oxygenase catalyzes the rate limiting step in the degradation of heme to bilirubin, it is essential for recycling of iron from heme. Heme is used as a substrate and cofactor for its own degradation to biliverdin, iron, and carbon monoxide. This...; Region: HemeO; cd00232 251221001007 heme binding pocket [chemical binding]; other site 251221001008 heme ligand [chemical binding]; other site 251221001009 AbrB-like transcriptional regulator; Region: AbrB-like; pfam14250 251221001010 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 251221001011 active site 251221001012 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 251221001013 rRNA binding site [nucleotide binding]; other site 251221001014 predicted 30S ribosome binding site; other site 251221001015 Phosphoenolpyruvate carboxylase [Carbohydrate transport and metabolism; Energy production and conversion]; Region: COG1892; cl14656 251221001016 Phosphoenolpyruvate carboxylase [Energy production and conversion]; Region: Ppc; COG2352 251221001017 S-layer homology domain; Region: SLH; pfam00395 251221001018 Carbohydrate-selective porin, OprB family; Region: OprB; pfam04966 251221001019 Carbohydrate-selective porin, OprB family; Region: OprB; pfam04966 251221001020 Isoprenoid Biosynthesis enzymes, Class 1; Region: Isoprenoid_Biosyn_C1; cl00210 251221001021 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971 251221001022 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 251221001023 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 251221001024 dimer interface [polypeptide binding]; other site 251221001025 phosphorylation site [posttranslational modification] 251221001026 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 251221001027 ATP binding site [chemical binding]; other site 251221001028 Mg2+ binding site [ion binding]; other site 251221001029 G-X-G motif; other site 251221001030 Cysteine-rich 4 helical bundle widely conserved in bacteria; Region: DUF326; cd08026 251221001031 dimerization interface [polypeptide binding]; other site 251221001032 short chain dehydrogenase; Provisional; Region: PRK06701 251221001033 classical (c) SDR, subgroup 1; Region: SDR_c1; cd05355 251221001034 NAD binding site [chemical binding]; other site 251221001035 metal binding site [ion binding]; metal-binding site 251221001036 active site 251221001037 putative alpha-isopropylmalate/homocitrate synthase family transferase; Provisional; Region: PRK12344 251221001038 Desulfobacterium autotrophicum LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA3; cd07941 251221001039 active site 251221001040 catalytic residues [active] 251221001041 metal binding site [ion binding]; metal-binding site 251221001042 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; cl07212 251221001043 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 251221001044 Catalytic domain of Protein Kinases; Region: PKc; cd00180 251221001045 active site 251221001046 ATP binding site [chemical binding]; other site 251221001047 substrate binding site [chemical binding]; other site 251221001048 activation loop (A-loop); other site 251221001049 Phage protein D [General function prediction only]; Region: COG3500; cl12180 251221001050 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 251221001051 T4-like virus tail tube protein gp19; Region: Phage_T4_gp19; cl12125 251221001052 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 251221001053 phosphopeptide binding site; other site 251221001054 Protein kinase domain; Region: Pkinase; pfam00069 251221001055 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 251221001056 active site 251221001057 substrate binding site [chemical binding]; other site 251221001058 ATP binding site [chemical binding]; other site 251221001059 activation loop (A-loop); other site 251221001060 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 251221001061 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 251221001062 phosphopeptide binding site; other site 251221001063 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 251221001064 dimer interface [polypeptide binding]; other site 251221001065 ssDNA binding site [nucleotide binding]; other site 251221001066 tetramer (dimer of dimers) interface [polypeptide binding]; other site 251221001067 Ribosomal protein S6; Region: Ribosomal_S6; cl00414 251221001068 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07656 251221001069 Acyl-protein synthetase, LuxE; Region: LuxE; cl15695 251221001070 phosphonate ABC transporter, ATP-binding protein; Region: ABC_phnC; TIGR02315 251221001071 ABC-type multidrug transport system, ATPase component. The biological function of this family is not well characterized, but display ABC domains similar to members of ABCA subfamily. ABC transporters are a large family of proteins involved in the...; Region: ABC_drug_resistance_like; cd03264 251221001072 ATP binding site [chemical binding]; other site 251221001073 Q-loop/lid; other site 251221001074 ABC transporter signature motif; other site 251221001075 Walker B; other site 251221001076 D-loop; other site 251221001077 H-loop/switch region; other site 251221001078 CpeT/CpcT family (DUF1001); Region: CpeT; pfam06206 251221001079 Protein of unknown function (DUF1469); Region: DUF1469; cl12095 251221001080 Phosphoribosylformylglycinamidine (FGAM) synthase; Region: PurS; cl00789 251221001081 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14360 251221001082 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 251221001083 Substrate binding site; other site 251221001084 Mg++ binding site; other site 251221001085 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 251221001086 active site 251221001087 substrate binding site [chemical binding]; other site 251221001088 CoA binding site [chemical binding]; other site 251221001089 Survival protein SurE; Region: SurE; cl00448 251221001090 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 251221001091 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 251221001092 dimer interface [polypeptide binding]; other site 251221001093 conserved gate region; other site 251221001094 putative PBP binding loops; other site 251221001095 ABC-ATPase subunit interface; other site 251221001096 phosphate transporter permease subunit PtsA; Provisional; Region: pstA; PRK11268 251221001097 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 251221001098 dimer interface [polypeptide binding]; other site 251221001099 conserved gate region; other site 251221001100 putative PBP binding loops; other site 251221001101 ABC-ATPase subunit interface; other site 251221001102 ABC-type phosphate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: PstB; COG1117 251221001103 Phosphate uptake is of fundamental importance in the cell physiology of bacteria because phosphate is required as a nutrient. The Pst system of E. coli comprises four distinct subunits encoded by the pstS, pstA, pstB, and pstC genes. The PstS protein...; Region: ABC_PstB_phosphate_transporter; cd03260 251221001104 Walker A/P-loop; other site 251221001105 ATP binding site [chemical binding]; other site 251221001106 Q-loop/lid; other site 251221001107 ABC transporter signature motif; other site 251221001108 Walker B; other site 251221001109 D-loop; other site 251221001110 H-loop/switch region; other site 251221001111 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 251221001112 tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224 251221001113 active site 251221001114 Int/Topo IB signature motif; other site 251221001115 DNA binding site [nucleotide binding] 251221001116 Periplasmic protein involved in polysaccharide export, contains SLBB domain of b-grasp fold [Cell wall/membrane/envelope biogenesis]; Region: Wza; COG1596 251221001117 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 251221001118 Uncharacterized protein involved in exopolysaccharide biosynthesis [Cell envelope biogenesis, outer membrane]; Region: GumC; COG3206 251221001119 capsular exopolysaccharide family; Region: eps_fam; TIGR01007 251221001120 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 251221001121 O-Antigen ligase; Region: Wzy_C; cl04850 251221001122 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 251221001123 active site 251221001124 MatE; Region: MatE; cl10513 251221001125 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 251221001126 Bacterial sugar transferase; Region: Bac_transf; cl00939 251221001127 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 251221001128 This family is most closely related to the GT1 family of glycosyltransferases. wlbH in Bordetella parapertussis has been shown to be required for the biosynthesis of a trisaccharide that, when attached to the B. pertussis lipopolysaccharide (LPS) core; Region: GT1_wlbH_like; cd03798 251221001129 Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as Transcription factor ImmunoGlobin (TIG) domains. They are present in intracellular transcription factors, cell surface receptors (such as plexins and scatter factor...; Region: IPT; cl15674 251221001130 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 251221001131 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 251221001132 Sulfotransferase domain; Region: Sulfotransfer_1; pfam00685 251221001133 Sulfotransferase domain; Region: Sulfotransfer_1; pfam00685 251221001134 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 251221001135 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_6; cd04955 251221001136 Alpha-L-arabinofuranosidase [Carbohydrate transport and metabolism]; Region: AbfA; COG3534 251221001137 dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088 251221001138 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 251221001139 NAD binding site [chemical binding]; other site 251221001140 substrate binding site [chemical binding]; other site 251221001141 homodimer interface [polypeptide binding]; other site 251221001142 active site 251221001143 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538 251221001144 glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207 251221001145 substrate binding site; other site 251221001146 tetramer interface; other site 251221001147 Cupin domain; Region: Cupin_2; cl09118 251221001148 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 251221001149 NTP_transferases catalyze the transfer of nucleotides onto phosphosugars; Region: NTP_transferase; cd04181 251221001150 active site 251221001151 Substrate binding site; other site 251221001152 Mg++ binding site; other site 251221001153 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 251221001154 putative trimer interface [polypeptide binding]; other site 251221001155 putative CoA binding site [chemical binding]; other site 251221001156 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 251221001157 PAS fold; Region: PAS_3; pfam08447 251221001158 putative active site [active] 251221001159 heme pocket [chemical binding]; other site 251221001160 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; cl01255 251221001161 Protein of unknown function (DUF3539); Region: DUF3539; pfam12058 251221001162 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 251221001163 Mg chelatase-related protein; Region: TIGR00368 251221001164 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 251221001165 5-methyltetrahydrofolate--homocysteine methyltransferase; Region: metH; TIGR02082 251221001166 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 251221001167 Uncharacterized conserved protein [Function unknown]; Region: COG5464 251221001168 Protein of unknown function (DUF2887); Region: DUF2887; pfam11103 251221001169 cyclase homology domain; Region: CHD; cd07302 251221001170 nucleotidyl binding site; other site 251221001171 metal binding site [ion binding]; metal-binding site 251221001172 dimer interface [polypeptide binding]; other site 251221001173 Response regulator receiver domain; Region: Response_reg; pfam00072 251221001174 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 251221001175 active site 251221001176 phosphorylation site [posttranslational modification] 251221001177 intermolecular recognition site; other site 251221001178 dimerization interface [polypeptide binding]; other site 251221001179 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 251221001180 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 251221001181 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 251221001182 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 251221001183 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3226 251221001184 Helix-turn-helix domains; Region: HTH; cl00088 251221001185 atypical (a) SDRs, subgroup 7; Region: SDR_a7; cd05262 251221001186 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 251221001187 putative NAD(P) binding site [chemical binding]; other site 251221001188 Aminoglycoside 3-N-acetyltransferase; Region: Antibiotic_NAT; cl01051 251221001189 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 251221001190 Helix-turn-helix domains; Region: HTH; cl00088 251221001191 DevC protein; Region: devC; TIGR01185 251221001192 FtsX-like permease family; Region: FtsX; pfam02687 251221001193 ABC exporter membrane fusion protein, DevB family; Region: heterocyst_DevB; TIGR02971 251221001194 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box protein; Region: CSP_CDS; cd04458 251221001195 DNA-binding site [nucleotide binding]; DNA binding site 251221001196 RNA-binding motif; other site 251221001197 Protein of unknown function (DUF1257); Region: DUF1257; cl06088 251221001198 PhoD-like phosphatase; Region: PhoD; pfam09423 251221001199 Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389 251221001200 putative active site [active] 251221001201 putative metal binding site [ion binding]; other site 251221001202 Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389 251221001203 Conserved hypothetical protein (Lin0512_fam); Region: Lin0512_fam; cl09807 251221001204 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 251221001205 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 251221001206 Walker A/P-loop; other site 251221001207 ATP binding site [chemical binding]; other site 251221001208 Q-loop/lid; other site 251221001209 ABC transporter signature motif; other site 251221001210 Walker B; other site 251221001211 D-loop; other site 251221001212 H-loop/switch region; other site 251221001213 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 251221001214 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 251221001215 FtsX-like permease family; Region: FtsX; pfam02687 251221001216 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 251221001217 FtsX-like permease family; Region: FtsX; pfam02687 251221001218 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 251221001219 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl12011 251221001220 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 251221001221 Walker A motif; other site 251221001222 ATP binding site [chemical binding]; other site 251221001223 Walker B motif; other site 251221001224 arginine finger; other site 251221001225 DNA-damage-inducible SOS response protein; Provisional; Region: PRK10367 251221001226 MatE; Region: MatE; cl10513 251221001227 MatE; Region: MatE; cl10513 251221001228 YhcR_OBF_like: A subfamily of OB-fold domains similar to the OB folds of Bacillus subtilis YhcR. YhcR is a sugar-nonspecific nuclease, which is active in the presence of Ca2+ and Mn2+. It cleaves RNA endonucleolytically, producing 3'-monophosphate...; Region: YhcR_OBF_like; cd04486 251221001229 generic binding surface II; other site 251221001230 generic binding surface I; other site 251221001231 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 251221001232 putative catalytic site [active] 251221001233 putative metal binding site [ion binding]; other site 251221001234 putative phosphate binding site [ion binding]; other site 251221001235 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 251221001236 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 251221001237 substrate binding site [chemical binding]; other site 251221001238 ATP binding site [chemical binding]; other site 251221001239 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 251221001240 Fructokinases (FRKs) mainly from bacteria and plants are enzymes with high specificity for fructose, as are all FRKs, but they catalyzes the conversion of fructose to fructose-6-phosphate, which is an entry point into glycolysis via conversion into...; Region: bac_FRK; cd01167 251221001241 putative substrate binding site [chemical binding]; other site 251221001242 putative ATP binding site [chemical binding]; other site 251221001243 bifunctional 3-demethylubiquinone-9 3-methyltransferase/ 2-octaprenyl-6-hydroxy phenol methylase; Provisional; Region: PRK05134 251221001244 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 251221001245 S-adenosylmethionine binding site [chemical binding]; other site 251221001246 Protein of unknown function (DUF445); Region: DUF445; pfam04286 251221001247 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 251221001248 putative active site [active] 251221001249 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 251221001250 catalytic triad [active] 251221001251 Domain of unknown function (DUF4175); Region: DUF4175; pfam13779 251221001252 Formate-dependent phosphoribosylglycinamide formyltransferase (GAR transformylase) [Nucleotide transport and metabolism]; Region: PurT; COG0027 251221001253 Ppx/GppA phosphatase family; Region: Ppx-GppA; cl15449 251221001254 Exopolyphosphatase [Nucleotide transport and metabolism / Inorganic ion transport and metabolism]; Region: GppA; COG0248 251221001255 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 251221001256 Zn2+ binding site [ion binding]; other site 251221001257 Mg2+ binding site [ion binding]; other site 251221001258 Cytochrome B6-F complex subunit 5; Region: PetG; cl03637 251221001259 shikimate kinase; Reviewed; Region: aroK; PRK00131 251221001260 Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically 'activated' sulfate form important for the assimilation of...; Region: APSK; cd02027 251221001261 ligand-binding site [chemical binding]; other site 251221001262 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 251221001263 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 251221001264 active site 251221001265 metal binding site [ion binding]; metal-binding site 251221001266 DNA binding site [nucleotide binding] 251221001267 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 251221001268 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 251221001269 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 251221001270 Cation transport protein; Region: TrkH; cl10514 251221001271 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 251221001272 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 251221001273 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl15357 251221001274 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 251221001275 putative active site [active] 251221001276 Transposase, Mutator family; Region: Transposase_mut; pfam00872 251221001277 MULE transposase domain; Region: MULE; pfam10551 251221001278 Transposase, Mutator family; Region: Transposase_mut; pfam00872 251221001279 tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795 251221001280 tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795 251221001281 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 251221001282 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic 'goose-type' lysozymes (GEWL). LTs catalyze...; Region: LT_GEWL; cd00254 251221001283 N-acetyl-D-glucosamine binding site [chemical binding]; other site 251221001284 catalytic residue [active] 251221001285 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 251221001286 active site 251221001287 metal binding site [ion binding]; metal-binding site 251221001288 prephenate dehydratase; Provisional; Region: PRK11898 251221001289 Prephenate dehydratase; Region: PDT; pfam00800 251221001290 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 251221001291 putative L-Phe binding site [chemical binding]; other site 251221001292 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 251221001293 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 251221001294 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 251221001295 NAD(P) binding pocket [chemical binding]; other site 251221001296 aromatic acid decarboxylase; Validated; Region: PRK05920 251221001297 Flavoprotein; Region: Flavoprotein; cl08021 251221001298 glyceraldehyde-3-phosphate dehydrogenase; Reviewed; Region: PRK07403 251221001299 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; cl15267 251221001300 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 251221001301 Maf_Ham1. Maf, a nucleotide binding protein, has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea. A Ham1-related protein from Methanococcus jannaschii is a novel NTPase that has been shown to hydrolyze nonstandard...; Region: Maf_Ham1; cl00276 251221001302 High-affinity nickel-transport protein; Region: NicO; cl00964 251221001303 The function of this protein family is unkown. The amino acid sequence of YjiA protein in E. coli contains several conserved motifs that characterizes it as a P-loop GTPase. YijA gene is among the genes significantly induced in response to DNA-damage...; Region: CobW_like; cd03112 251221001304 P-loop, Walker A motif; other site 251221001305 Base recognition motif; other site 251221001306 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; cl08458 251221001307 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 251221001308 structural tetrad; other site 251221001309 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 251221001310 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 251221001311 S-adenosylmethionine binding site [chemical binding]; other site 251221001312 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 251221001313 putative active site [active] 251221001314 catalytic residue [active] 251221001315 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 251221001316 dihydropteroate synthase; Region: DHPS; TIGR01496 251221001317 substrate binding pocket [chemical binding]; other site 251221001318 dimer interface [polypeptide binding]; other site 251221001319 inhibitor binding site; inhibition site 251221001320 PRC-barrel domain containing protein [General function prediction only]; Region: COG3881 251221001321 Photosynthetic reaction center (RC) complex, subunit H; RC is an integral membrane protein-pigment complex which catalyzes light-induced reduction of ubiquinone to ubiquinol, generating a transmembrane electrochemical gradient of protons used to produce...; Region: PRCH; cl09959 251221001322 Mitochondrial ATP synthase B chain precursor (ATP-synt_B); Region: Mt_ATP-synt_B; cl07975 251221001323 Protein of unknown function DUF111; Region: DUF111; cl03398 251221001324 Type IV pilus biogenesis; Region: Pilus_PilP; cl11837 251221001325 Protein of unknown function (DUF1517); Region: DUF1517; cl01807 251221001326 acetylornithine aminotransferase; Provisional; Region: PRK02627 251221001327 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 251221001328 inhibitor-cofactor binding pocket; inhibition site 251221001329 pyridoxal 5'-phosphate binding site [chemical binding]; other site 251221001330 catalytic residue [active] 251221001331 Helix-turn-helix domain; Region: HTH_18; pfam12833 251221001332 Dienelactone hydrolase family; Region: DLH; pfam01738 251221001333 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 251221001334 Domain of unknown function DUF29; Region: DUF29; pfam01724 251221001335 tRNA methyl transferase; Region: tRNA_Me_trans; pfam03054 251221001336 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 251221001337 Ligand Binding Site [chemical binding]; other site 251221001338 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 251221001339 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; cl06870 251221001340 SpoU rRNA Methylase family; Region: SpoU_methylase; cl00362 251221001341 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 251221001342 Glucose/sorbosone dehydrogenases [Carbohydrate transport and metabolism]; Region: COG2133 251221001343 FOG: PKD repeat [General function prediction only]; Region: COG3291 251221001344 polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cd00146 251221001345 Protein of unknown function (DUF3326); Region: DUF3326; pfam11805 251221001346 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 251221001347 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 251221001348 purine monophosphate binding site [chemical binding]; other site 251221001349 dimer interface [polypeptide binding]; other site 251221001350 putative catalytic residues [active] 251221001351 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 251221001352 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 251221001353 Bacterial protein of unknown function (DUF839); Region: DUF839; pfam05787 251221001354 Protein of unknown function (DUF2283); Region: DUF2283; cl02251 251221001355 mercuric reductase; Validated; Region: PRK06370 251221001356 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 251221001357 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 251221001358 chromate transporter, chromate ion transporter (CHR) family; Region: 2A51; TIGR00937 251221001359 Chromate transporter; Region: Chromate_transp; pfam02417 251221001360 Chromate transporter; Region: Chromate_transp; pfam02417 251221001361 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383 251221001362 Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cl12039 251221001363 active site 251221001364 dimer interface [polypeptide binding]; other site 251221001365 Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cl12039 251221001366 Dienelactone hydrolase family; Region: DLH; pfam01738 251221001367 Osmosensitive K+ channel His kinase sensor domain; Region: KdpD; pfam02702 251221001368 USP domain is located between the N-terminal sensor domain and C-terminal catalytic domain of this Osmosensitive K+ channel histidine kinase family. The family of KdpD sensor kinase proteins regulates the kdpFABC operon responsible for potassium...; Region: USP_OKCHK; cd01987 251221001369 Ligand Binding Site [chemical binding]; other site 251221001370 Osmosensitive K+ channel His kinase sensor domain; Region: KdpD; pfam02702 251221001371 USP domain is located between the N-terminal sensor domain and C-terminal catalytic domain of this Osmosensitive K+ channel histidine kinase family. The family of KdpD sensor kinase proteins regulates the kdpFABC operon responsible for potassium...; Region: USP_OKCHK; cd01987 251221001372 Ligand Binding Site [chemical binding]; other site 251221001373 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 251221001374 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 251221001375 active site 251221001376 phosphorylation site [posttranslational modification] 251221001377 intermolecular recognition site; other site 251221001378 dimerization interface [polypeptide binding]; other site 251221001379 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 251221001380 DNA binding residues [nucleotide binding] 251221001381 dimerization interface [polypeptide binding]; other site 251221001382 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 251221001383 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 251221001384 dimer interface [polypeptide binding]; other site 251221001385 phosphorylation site [posttranslational modification] 251221001386 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 251221001387 ATP binding site [chemical binding]; other site 251221001388 Mg2+ binding site [ion binding]; other site 251221001389 G-X-G motif; other site 251221001390 Potassium-transporting ATPase A subunit; Region: KdpA; cl00903 251221001391 potassium-transporting ATPase subunit B; Provisional; Region: PRK01122 251221001392 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 251221001393 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 251221001394 K+-transporting ATPase, c chain; Region: KdpC; cl00944 251221001395 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 251221001396 putative active site [active] 251221001397 hemin importer ATP-binding subunit; Provisional; Region: hmuV; PRK13548 251221001398 ABC transporters, involved in the uptake of siderophores, heme, and vitamin B12, are widely conserved in bacteria and archaea. Only very few species lack representatives of the siderophore family transporters. The E. coli BtuCD protein is an ABC...; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 251221001399 Walker A/P-loop; other site 251221001400 ATP binding site [chemical binding]; other site 251221001401 Q-loop/lid; other site 251221001402 ABC transporter signature motif; other site 251221001403 Walker B; other site 251221001404 D-loop; other site 251221001405 H-loop/switch region; other site 251221001406 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 251221001407 dimer interface [polypeptide binding]; other site 251221001408 putative PBP binding regions; other site 251221001409 ABC-ATPase subunit interface; other site 251221001410 Hemin binding protein HutB. These proteins have been shown to function as initial receptors in ABC transport of hemin and hemoproteins in many eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that share a...; Region: HutB; cd01149 251221001411 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 251221001412 putative hemin binding site; other site 251221001413 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506 251221001414 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 251221001415 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 251221001416 putative active site [active] 251221001417 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2911 251221001418 Protein of unknown function (DUF1345); Region: DUF1345; cl01753 251221001419 Catalytic domain of Protein Kinases; Region: PKc; cd00180 251221001420 active site 251221001421 ATP binding site [chemical binding]; other site 251221001422 substrate binding site [chemical binding]; other site 251221001423 activation loop (A-loop); other site 251221001424 TolB amino-terminal domain; Region: TolB_N; cl00639 251221001425 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 251221001426 binding surface 251221001427 TPR motif; other site 251221001428 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 251221001429 binding surface 251221001430 TPR motif; other site 251221001431 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 251221001432 Probable transposase; Region: OrfB_IS605; pfam01385 251221001433 Conserved nitrate reductase-associated protein (Nitr_red_assoc); Region: Nitr_red_assoc; cl09869 251221001434 polynucleotide kinase-phosphatase; Region: bacter_Pnkp; TIGR04075 251221001435 Bacterial protein of unknown function (DUF885); Region: DUF885; pfam05960 251221001436 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl12011 251221001437 Beta-lactamase class A [Defense mechanisms]; Region: PenP; COG2367 251221001438 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 251221001439 Uncharacterized conserved protein [Function unknown]; Region: COG0397; cl00428 251221001440 Uncharacterized ACR, YdiU/UPF0061 family; Region: UPF0061; pfam02696 251221001441 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 251221001442 putative ABC transporter ATP-binding protein; Reviewed; Region: PRK11819 251221001443 Walker A/P-loop; other site 251221001444 ATP binding site [chemical binding]; other site 251221001445 Q-loop/lid; other site 251221001446 ABC transporter signature motif; other site 251221001447 Walker B; other site 251221001448 D-loop; other site 251221001449 H-loop/switch region; other site 251221001450 ABC transporter; Region: ABC_tran_2; pfam12848 251221001451 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 251221001452 ABC transporter; Region: ABC_tran_2; pfam12848 251221001453 MgtC family; Region: MgtC; cl12207 251221001454 Predicted proteasome-type protease [Posttranslational modification, protein turnover, chaperones]; Region: COG3484 251221001455 Bacterial proteasome, beta subunit. The 20S proteasome, multisubunit proteolytic complex, is the central enzyme of nonlysosomal protein degradation in both the cytosol and nucleus. It is composed of 28 subunits arranged as four homoheptameric rings that...; Region: proteasome_beta_bacterial; cd03765 251221001456 Alternative oxidase, ferritin-like diiron-binding domain; Region: AOX; cd01053 251221001457 diiron binding motif [ion binding]; other site 251221001458 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cl01898 251221001459 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 251221001460 TPR motif; other site 251221001461 binding surface 251221001462 Transposase domain (DUF772); Region: DUF772; cl12084 251221001463 Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; cl00398 251221001464 Putative modulator of DNA gyrase; Region: PmbA_TldD; pfam01523 251221001465 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 251221001466 Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199 251221001467 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 251221001468 Uncharacterised protein family (UPF0175); Region: UPF0175; cl01085 251221001469 Predicted nucleic acid-binding protein, contains PIN domain [General function prediction only]; Region: COG2405 251221001470 Domain of unknown function (DUF3368); Region: DUF3368; pfam11848 251221001471 AAA-like domain; Region: AAA_10; pfam12846 251221001472 Putative peptidoglycan binding domain; Region: PG_binding_1; cl15437 251221001473 Serine proteases of the peptidase family S9A [Amino acid transport and metabolism]; Region: COG1505 251221001474 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 251221001475 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 251221001476 protein binding site [polypeptide binding]; other site 251221001477 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 251221001478 protein binding site [polypeptide binding]; other site 251221001479 Integral membrane protein TerC family; Region: TerC; cl10468 251221001480 Uncharacterised protein family UPF0047; Region: UPF0047; cl00439 251221001481 helicase, putative, RecD/TraA family; Region: recD_rel; TIGR01448 251221001482 PemK-like protein; Region: PemK; cl00995 251221001483 PIN domain of the Pyrobaculum aerophilum Pae0151 and Pae2754 proteins and homologs; Region: PIN_Pae0151; cd09873 251221001484 putative active site [active] 251221001485 homotetrameric interface [polypeptide binding]; other site 251221001486 metal binding site [ion binding]; metal-binding site 251221001487 Phd_YefM; Region: PhdYeFM; cl09153 251221001488 Response regulator receiver domain; Region: Response_reg; pfam00072 251221001489 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 251221001490 active site 251221001491 phosphorylation site [posttranslational modification] 251221001492 intermolecular recognition site; other site 251221001493 dimerization interface [polypeptide binding]; other site 251221001494 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 251221001495 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 251221001496 putative active site [active] 251221001497 heme pocket [chemical binding]; other site 251221001498 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 251221001499 dimer interface [polypeptide binding]; other site 251221001500 phosphorylation site [posttranslational modification] 251221001501 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 251221001502 ATP binding site [chemical binding]; other site 251221001503 Mg2+ binding site [ion binding]; other site 251221001504 G-X-G motif; other site 251221001505 Response regulator receiver domain; Region: Response_reg; pfam00072 251221001506 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 251221001507 active site 251221001508 phosphorylation site [posttranslational modification] 251221001509 intermolecular recognition site; other site 251221001510 dimerization interface [polypeptide binding]; other site 251221001511 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 251221001512 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 251221001513 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 251221001514 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 251221001515 GAF domain; Region: GAF; cl00853 251221001516 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080 251221001517 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 251221001518 ATP binding site [chemical binding]; other site 251221001519 Mg2+ binding site [ion binding]; other site 251221001520 G-X-G motif; other site 251221001521 Response regulator receiver domain; Region: Response_reg; pfam00072 251221001522 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 251221001523 active site 251221001524 phosphorylation site [posttranslational modification] 251221001525 intermolecular recognition site; other site 251221001526 dimerization interface [polypeptide binding]; other site 251221001527 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 251221001528 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 251221001529 active site 251221001530 phosphorylation site [posttranslational modification] 251221001531 intermolecular recognition site; other site 251221001532 Response regulator receiver domain; Region: Response_reg; pfam00072 251221001533 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 251221001534 active site 251221001535 phosphorylation site [posttranslational modification] 251221001536 intermolecular recognition site; other site 251221001537 dimerization interface [polypeptide binding]; other site 251221001538 DNA polymerase I; Provisional; Region: PRK05755 251221001539 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 251221001540 active site 251221001541 metal binding site 1 [ion binding]; metal-binding site 251221001542 putative 5' ssDNA interaction site; other site 251221001543 metal binding site 3; metal-binding site 251221001544 metal binding site 2 [ion binding]; metal-binding site 251221001545 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 251221001546 putative DNA binding site [nucleotide binding]; other site 251221001547 putative metal binding site [ion binding]; other site 251221001548 DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase I and similar bacterial family-A DNA polymerases; Region: DNA_polA_I_Ecoli_like_exo; cd06139 251221001549 active site 251221001550 catalytic site [active] 251221001551 substrate binding site [chemical binding]; other site 251221001552 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 251221001553 active site 251221001554 DNA binding site [nucleotide binding] 251221001555 catalytic site [active] 251221001556 Protein of unknown function (DUF2993); Region: DUF2993; pfam11209 251221001557 S-layer homology domain; Region: SLH; pfam00395 251221001558 Carbohydrate-selective porin, OprB family; Region: OprB; pfam04966 251221001559 Carbohydrate-selective porin, OprB family; Region: OprB; pfam04966 251221001560 formamidopyrimidine-DNA glycosylase (fpg); Region: fpg; TIGR00577 251221001561 Sulfatase; Region: Sulfatase; cl10460 251221001562 Family description; Region: VCBS; pfam13517 251221001563 Family description; Region: VCBS; pfam13517 251221001564 Family description; Region: VCBS; pfam13517 251221001565 Family description; Region: VCBS; pfam13517 251221001566 Family description; Region: VCBS; pfam13517 251221001567 Sulfatase; Region: Sulfatase; cl10460 251221001568 Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177 251221001569 cell division ATP-binding protein FtsE; Region: FtsE; TIGR02673 251221001570 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 251221001571 Walker A/P-loop; other site 251221001572 ATP binding site [chemical binding]; other site 251221001573 Q-loop/lid; other site 251221001574 ABC transporter signature motif; other site 251221001575 Walker B; other site 251221001576 D-loop; other site 251221001577 H-loop/switch region; other site 251221001578 The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533 251221001579 NADH-ubiquinone/plastoquinone oxidoreductase chain 4L; Region: Oxidored_q2; cl00492 251221001580 NADH dehydrogenase subunit 6; Region: ndhG; CHL00016 251221001581 NADH dehydrogenase subunit J; Provisional; Region: PRK06433; cl14634 251221001582 NADH-plastoquinone oxidoreductase subunit I protein; Region: ndhI; TIGR00403 251221001583 4Fe-4S binding domain; Region: Fer4; cl02805 251221001584 Putative membrane peptidase family (DUF2324); Region: DUF2324; cl01810 251221001585 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 251221001586 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 251221001587 minor groove reading motif; other site 251221001588 helix-hairpin-helix signature motif; other site 251221001589 substrate binding pocket [chemical binding]; other site 251221001590 active site 251221001591 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 251221001592 Catalytic domain of Protein Kinases; Region: PKc; cd00180 251221001593 active site 251221001594 ATP binding site [chemical binding]; other site 251221001595 substrate binding site [chemical binding]; other site 251221001596 activation loop (A-loop); other site 251221001597 Protein of unknown function (DUF3365); Region: DUF3365; pfam11845 251221001598 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 251221001599 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl15260 251221001600 Domain of unknown function (DUF205); Region: DUF205; cl00410 251221001601 Protein of unknown function (DUF3119); Region: DUF3119; pfam11317 251221001602 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 251221001603 Catalytic domain of Protein Kinases; Region: PKc; cd00180 251221001604 active site 251221001605 ATP binding site [chemical binding]; other site 251221001606 substrate binding site [chemical binding]; other site 251221001607 activation loop (A-loop); other site 251221001608 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 251221001609 MPT binding site; other site 251221001610 trimer interface [polypeptide binding]; other site 251221001611 tellurium resistance terB-like protein; Region: terB_like; cl11965 251221001612 GT_2_like_a represents a glycosyltransferase family-2 subfamily with unknown function; Region: GT_2_like_a; cd02522 251221001613 Probable Catalytic site; other site 251221001614 RNA polymerase sigma-70 factor, TIGR02957 family; Region: SigX4 251221001615 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 251221001616 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cl15358 251221001617 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 251221001618 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 251221001619 Helix-turn-helix domains; Region: HTH; cl00088 251221001620 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 251221001621 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 251221001622 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 251221001623 ABC-2 type transporter; Region: ABC2_membrane; cl11417 251221001624 The ABCA subfamily mediates the transport of a variety of lipid compounds. Mutations of members of ABCA subfamily are associated with human genetic diseases, such as, familial high-density lipoprotein (HDL) deficiency, neonatal surfactant deficiency; Region: ABC_subfamily_A; cd03263 251221001625 nodulation ABC transporter NodI; Provisional; Region: PRK13537 251221001626 Walker A/P-loop; other site 251221001627 ATP binding site [chemical binding]; other site 251221001628 Q-loop/lid; other site 251221001629 ABC transporter signature motif; other site 251221001630 Walker B; other site 251221001631 D-loop; other site 251221001632 H-loop/switch region; other site 251221001633 thymidylate kinase; Validated; Region: tmk; PRK00698 251221001634 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 251221001635 TMP-binding site; other site 251221001636 ATP-binding site [chemical binding]; other site 251221001637 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 251221001638 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; cl08040 251221001639 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019 251221001640 Serine proteases of the peptidase family S9A [Amino acid transport and metabolism]; Region: COG1505 251221001641 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 251221001642 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 251221001643 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 251221001644 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 251221001645 Protein of unknown function DUF72; Region: DUF72; cl00777 251221001646 CAAX amino terminal protease self- immunity; Region: Abi; cl00558 251221001647 Helix-turn-helix domains; Region: HTH; cl00088 251221001648 This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300 251221001649 homodimer interface [polypeptide binding]; other site 251221001650 glycogen/starch/alpha-glucan phosphorylases; Region: P_ylase; TIGR02093 251221001651 active site pocket [active] 251221001652 Nitrogen regulatory protein P-II; Region: P-II; cl00412 251221001653 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 251221001654 Ligand Binding Site [chemical binding]; other site 251221001655 BolA-like protein; Region: BolA; cl00386 251221001656 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 251221001657 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 251221001658 This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300 251221001659 homodimer interface [polypeptide binding]; other site 251221001660 glycogen/starch/alpha-glucan phosphorylases; Region: P_ylase; TIGR02093 251221001661 active site pocket [active] 251221001662 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 251221001663 putative active site [active] 251221001664 A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cl00279 251221001665 D-alanyl-D-alanine carboxypeptidase; Region: VanY; cl00813 251221001666 SpoU rRNA Methylase family; Region: SpoU_methylase; cl00362 251221001667 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 251221001668 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 251221001669 Ligand binding site; other site 251221001670 Putative Catalytic site; other site 251221001671 DXD motif; other site 251221001672 UDP-N-acetylglucosamine 2-epimerase; Region: wecB; TIGR00236 251221001673 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 251221001674 active site 251221001675 homodimer interface [polypeptide binding]; other site 251221001676 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635 251221001677 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 251221001678 catalytic residue [active] 251221001679 Protein of unknown function (DUF552); Region: DUF552; cl00775 251221001680 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 251221001681 pyrroline-5-carboxylate reductase; Region: proC; TIGR00112 251221001682 Bacterial aspartate proteases, retropepsin-like protease family; Region: retropepsin_like_bacteria; cd05483 251221001683 catalytic motif [active] 251221001684 Catalytic residue [active] 251221001685 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 251221001686 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 251221001687 catalytic residues [active] 251221001688 Gram-negative bacterial tonB protein; Region: TonB; cl10048 251221001689 16S rRNA methyltransferase GidB; Reviewed; Region: gidB; PRK00107 251221001690 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 251221001691 S-adenosylmethionine binding site [chemical binding]; other site 251221001692 SOS regulatory protein LexA; Region: lexA; TIGR00498 251221001693 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 251221001694 active site 251221001695 multimer interface [polypeptide binding]; other site 251221001696 mttA/Hcf106 family; Region: MttA_Hcf106; cl00788 251221001697 Rad52/22 family double-strand break repair protein; Region: Rad52_Rad22; cl01936 251221001698 Bleomycin binding protein (BLMA) and similar proteins; BLMA confers bleomycin (Bm) resistance by directly binding to Bm; Region: BLMA_like; cd08349 251221001699 dimer interface [polypeptide binding]; other site 251221001700 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 251221001701 ligand binding site [chemical binding]; other site 251221001702 Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as Transcription factor ImmunoGlobin (TIG) domains. They are present in intracellular transcription factors, cell surface receptors (such as plexins and scatter factor...; Region: IPT; cd00102 251221001703 photosystem I assembly protein Ycf3; Provisional; Region: PRK02603 251221001704 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 251221001705 binding surface 251221001706 TPR motif; other site 251221001707 seryl-tRNA synthetase; Provisional; Region: PRK05431 251221001708 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 251221001709 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme bound...; Region: SerRS_core; cd00770 251221001710 dimer interface [polypeptide binding]; other site 251221001711 active site 251221001712 motif 1; other site 251221001713 motif 2; other site 251221001714 motif 3; other site 251221001715 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 251221001716 haloacid dehalogenase superfamily, subfamily IA, variant 1 with third motif having Dx(3-4)D or Dx(3-4)E; Region: HAD-SF-IA-v1; TIGR01549 251221001717 PAS fold; Region: PAS_4; pfam08448 251221001718 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 251221001719 GAF domain; Region: GAF; cl00853 251221001720 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 251221001721 dimer interface [polypeptide binding]; other site 251221001722 phosphorylation site [posttranslational modification] 251221001723 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 251221001724 ATP binding site [chemical binding]; other site 251221001725 Mg2+ binding site [ion binding]; other site 251221001726 G-X-G motif; other site 251221001727 Response regulator receiver domain; Region: Response_reg; pfam00072 251221001728 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 251221001729 active site 251221001730 phosphorylation site [posttranslational modification] 251221001731 intermolecular recognition site; other site 251221001732 dimerization interface [polypeptide binding]; other site 251221001733 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 251221001734 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 251221001735 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 251221001736 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 251221001737 dimerization interface [polypeptide binding]; other site 251221001738 putative ATP binding site [chemical binding]; other site 251221001739 PIN domain of the Pyrobaculum aerophilum Pae0151 and Pae2754 proteins and homologs; Region: PIN_Pae0151; cd09873 251221001740 putative active site [active] 251221001741 homotetrameric interface [polypeptide binding]; other site 251221001742 metal binding site [ion binding]; metal-binding site 251221001743 RNA polymerase sigma-70 factor, sigma-B/F/G subfamily; Region: SigBFG; TIGR02980 251221001744 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cl15358 251221001745 Protein of unknown function (DUF1822); Region: DUF1822; pfam08852 251221001746 Caspase, interleukin-1 beta converting enzyme (ICE) homologues; Cysteine-dependent aspartate-directed proteases that mediate programmed cell death (apoptosis). Caspases are synthesized as inactive zymogens and activated by proteolysis of the peptide...; Region: CASc; cl00042 251221001747 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 251221001748 structural tetrad; other site 251221001749 FOG: WD40 repeat [General function prediction only]; Region: COG2319 251221001750 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 251221001751 structural tetrad; other site 251221001752 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 251221001753 putative active site [active] 251221001754 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 251221001755 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 251221001756 nucleotide binding pocket [chemical binding]; other site 251221001757 K-X-D-G motif; other site 251221001758 catalytic site [active] 251221001759 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 251221001760 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 251221001761 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 251221001762 Dimer interface [polypeptide binding]; other site 251221001763 BRCT sequence motif; other site 251221001764 Protein of unknown function (DUF1361); Region: DUF1361; cl01784 251221001765 Peptidase M1 Aminopeptidase N family incudes tricorn interacting factor F3, Endoplasmic reticulum aminopeptidase 1 (ERAP1), Aminopeptidase Q (APQ); Region: M1_APN_2; cd09601 251221001766 Zn binding site [ion binding]; other site 251221001767 Domain of unknown function (DUF3358); Region: DUF3358; pfam11838 251221001768 Zinc-dependent metalloprotease; MMP_like sub-family 2. A group of bacterial metalloproteinase domains similar to matrix metalloproteinases and astacin; Region: ZnMc_MMP_like_2; cd04276 251221001769 active site 251221001770 The GIY-YIG domain of uncharacterized protein family UPF0213 related to structure-specific endonuclease SLX1; Region: GIY-YIG_UPF0213; cd10456 251221001771 GIY-YIG motif/motif A; other site 251221001772 putative active site [active] 251221001773 putative metal binding site [ion binding]; other site 251221001774 NeuB family; Region: NeuB; cl00496 251221001775 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 251221001776 Glutathione-dependent formaldehyde dehydrogenase related proteins, child 1; Region: FDH_like_1; cd08283 251221001777 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 251221001778 NAD binding site [chemical binding]; other site 251221001779 catalytic Zn binding site [ion binding]; other site 251221001780 structural Zn binding site [ion binding]; other site 251221001781 Predicted integral membrane protein [Function unknown]; Region: COG5637 251221001782 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_8; cd07817 251221001783 putative hydrophobic ligand binding site [chemical binding]; other site 251221001784 Predicted membrane protein (DUF2231); Region: DUF2231; cl01730 251221001785 Predicted membrane protein (DUF2231); Region: DUF2231; cl01730 251221001786 Cytochrome C oxidase subunit II, transmembrane domain; Region: COX2_TM; pfam02790 251221001787 cytochrome c oxidase, subunit II; Region: CoxB; TIGR02866 251221001788 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; cl11412 251221001789 cytochrome c oxidase subunit I; Validated; Region: COX1; MTH00007 251221001790 Heme-copper oxidase subunit I. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which catalyze the reduction of O2 and simultaneously pump protons across the membrane. The superfamily is...; Region: Heme_Cu_Oxidase_I; cl00275 251221001791 D-pathway; other site 251221001792 Low-spin heme binding site [chemical binding]; other site 251221001793 Putative water exit pathway; other site 251221001794 Binuclear center (active site) [active] 251221001795 K-pathway; other site 251221001796 Putative proton exit pathway; other site 251221001797 Chlorophyll A-B binding protein; Region: Chloroa_b-bind; cl02879 251221001798 short chain dehydrogenase; Provisional; Region: PRK07109 251221001799 classical (c) SDR, subgroup 3; Region: SDR_c3; cd05360 251221001800 putative NAD(P) binding site [chemical binding]; other site 251221001801 active site 251221001802 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 251221001803 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl09944 251221001804 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 251221001805 DNA binding residues [nucleotide binding] 251221001806 Polysaccharide pyruvyl transferase family protein [Cell wall/membrane/envelope biogenesis]; Region: WcaK; cl09156 251221001807 ATP-dependent Clp protease adaptor protein ClpS; Region: ClpS; cl00933 251221001808 Adenosylcobinamide kinase / adenosylcobinamide phosphate guanyltransferase (CobU). CobU is bifunctional cobalbumin biosynthesis enzymes which display adenosylcobinamide kinase and adenosylcobinamide phosphate guanyltransferase activity. This enzyme is a...; Region: CobU; cd00544 251221001809 homotrimer interface [polypeptide binding]; other site 251221001810 Walker A motif; other site 251221001811 GTP binding site [chemical binding]; other site 251221001812 Walker B motif; other site 251221001813 NADH-ubiquinone/plastoquinone oxidoreductase, chain 3; Region: Oxidored_q4; cl00535 251221001814 NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; cl00419 251221001815 Respiratory-chain NADH dehydrogenase, 30 Kd subunit; Region: Complex1_30kDa; cl15698 251221001816 Protein of unknown function (DUF1622); Region: DUF1622; cl01991 251221001817 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 251221001818 hypothetical protein; Provisional; Region: PRK08185 251221001819 intersubunit interface [polypeptide binding]; other site 251221001820 active site 251221001821 zinc binding site [ion binding]; other site 251221001822 Na+ binding site [ion binding]; other site 251221001823 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 251221001824 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 251221001825 substrate binding pocket [chemical binding]; other site 251221001826 chain length determination region; other site 251221001827 substrate-Mg2+ binding site; other site 251221001828 catalytic residues [active] 251221001829 aspartate-rich region 1; other site 251221001830 active site lid residues [active] 251221001831 aspartate-rich region 2; other site 251221001832 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl09108 251221001833 Stage II sporulation protein; Region: SpoIID; pfam08486 251221001834 Sulfatase; Region: Sulfatase; cl10460 251221001835 Phosphoglyceromutase [Carbohydrate transport and metabolism]; Region: GpmI; COG0696 251221001836 aminodeoxychorismate synthase, component I, clade 2; Region: PabB-clade2; TIGR01824 251221001837 chorismate binding enzyme; Region: Chorismate_bind; cl10555 251221001838 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; cl00360 251221001839 Peptidase M14-like domain; uncharacterized subgroup; Region: M14-like_1_3; cd06240 251221001840 putative active site [active] 251221001841 Zn binding site [ion binding]; other site 251221001842 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 251221001843 FOG: Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3385 251221001844 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 251221001845 oligomerization interface [polypeptide binding]; other site 251221001846 active site 251221001847 metal binding site [ion binding]; metal-binding site 251221001848 GDP-mannose 4,6-dehydratase; Region: PLN02653 251221001849 GDP-mannose 4,6 dehydratase, extended (e) SDRs; Region: GDP_MD_SDR_e; cd05260 251221001850 NADP-binding site; other site 251221001851 homotetramer interface [polypeptide binding]; other site 251221001852 substrate binding site [chemical binding]; other site 251221001853 homodimer interface [polypeptide binding]; other site 251221001854 active site 251221001855 GDP-mannose 4,6 dehydratase, extended (e) SDRs; Region: GDP_MD_SDR_e; cd05260 251221001856 GDP-mannose 4,6-dehydratase; Region: PLN02653 251221001857 NADP-binding site; other site 251221001858 homotetramer interface [polypeptide binding]; other site 251221001859 substrate binding site [chemical binding]; other site 251221001860 homodimer interface [polypeptide binding]; other site 251221001861 active site 251221001862 cysteine synthase B; Region: cysM; TIGR01138 251221001863 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 251221001864 dimer interface [polypeptide binding]; other site 251221001865 pyridoxal 5'-phosphate binding site [chemical binding]; other site 251221001866 catalytic residue [active] 251221001867 Peptidase family M48; Region: Peptidase_M48; cl12018 251221001868 Helix-turn-helix domains; Region: HTH; cl00088 251221001869 Domain of unknown function DUF29; Region: DUF29; pfam01724 251221001870 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 251221001871 putative active site pocket [active] 251221001872 4-fold oligomerization interface [polypeptide binding]; other site 251221001873 metal binding residues [ion binding]; metal-binding site 251221001874 3-fold/trimer interface [polypeptide binding]; other site 251221001875 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 251221001876 phosphopeptide binding site; other site 251221001877 Putative membrane peptidase family (DUF2324); Region: DUF2324; cl01810 251221001878 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 251221001879 catalytic core [active] 251221001880 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 251221001881 catalytic core [active] 251221001882 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 251221001883 binding surface 251221001884 TPR motif; other site 251221001885 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 251221001886 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 251221001887 active site 251221001888 phosphorylation site [posttranslational modification] 251221001889 intermolecular recognition site; other site 251221001890 dimerization interface [polypeptide binding]; other site 251221001891 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 251221001892 DNA binding residues [nucleotide binding] 251221001893 dimerization interface [polypeptide binding]; other site 251221001894 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 251221001895 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 251221001896 FtsX-like permease family; Region: FtsX; pfam02687 251221001897 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 251221001898 FO synthase subunit 2; Reviewed; Region: PRK07360 251221001899 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 251221001900 FeS/SAM binding site; other site 251221001901 hypothetical protein; Validated; Region: PRK06769 251221001902 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 251221001903 active site 251221001904 motif I; other site 251221001905 motif II; other site 251221001906 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 251221001907 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 251221001908 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 251221001909 D1, D2 subunits of photosystem II (PSII); M, L subunits of bacterial photosynthetic reaction center; Region: Photo_RC; cl08220 251221001910 pheophytin binding site; other site 251221001911 chlorophyll binding site; other site 251221001912 quinone binding site; other site 251221001913 Fe binding site [ion binding]; other site 251221001914 FGGY family of carbohydrate kinases; Region: FGGY; cl08364 251221001915 N- and C-terminal domain interface [polypeptide binding]; other site 251221001916 active site 251221001917 MgATP binding site [chemical binding]; other site 251221001918 catalytic site [active] 251221001919 metal binding site [ion binding]; metal-binding site 251221001920 carbohydrate binding site [chemical binding]; other site 251221001921 Domain of unknown function (DUF1825); Region: DUF1825; pfam08855 251221001922 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 251221001923 metal binding site 2 [ion binding]; metal-binding site 251221001924 putative DNA binding helix; other site 251221001925 metal binding site 1 [ion binding]; metal-binding site 251221001926 dimer interface [polypeptide binding]; other site 251221001927 structural Zn2+ binding site [ion binding]; other site 251221001928 deoxyribodipyrimidine photo-lyase, 8-HDF type; Region: photolyase_8HDF; TIGR03556 251221001929 DNA photolyase; Region: DNA_photolyase; pfam00875 251221001930 FAD binding domain of DNA photolyase; Region: FAD_binding_7; pfam03441 251221001931 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 251221001932 Domain of unknown function DUF21; Region: DUF21; pfam01595 251221001933 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 251221001934 Transporter associated domain; Region: CorC_HlyC; cl08393 251221001935 RaiA ('ribosome-associated inhibitor A', also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal A site; Region: RaiA; cl00250 251221001936 Domain of unknown function DUF143; Region: DUF143; cl00519 251221001937 Predicted HD superfamily hydrolase involved in NAD metabolism [Coenzyme metabolism]; Region: COG1713 251221001938 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 251221001939 Methylenetetrahydrofolate reductase; Region: MTHFR; pfam02219 251221001940 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 251221001941 FAD binding site [chemical binding]; other site 251221001942 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 251221001943 Peptidase family M23; Region: Peptidase_M23; pfam01551 251221001944 Adenosine kinase (AK) catalyzes the phosphorylation of ribofuranosyl-containing nucleoside analogues at the 5'-hydroxyl using ATP or GTP as the phosphate donor.The physiological function of AK is associated with the regulation of extracellular adenosine...; Region: adenosine_kinase; cd01168 251221001945 substrate binding site [chemical binding]; other site 251221001946 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 251221001947 ATP binding site [chemical binding]; other site 251221001948 Ribosomal L32p protein family; Region: Ribosomal_L32p; cl09115 251221001949 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 251221001950 haloacid dehalogenase-like hydrolase family protein; Region: PLN02919 251221001951 NHL repeat; Region: NHL; pfam01436 251221001952 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 251221001953 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 251221001954 Rrf2 family protein; Region: rrf2_super; TIGR00738 251221001955 Helix-turn-helix domains; Region: HTH; cl00088 251221001956 cysteine synthase; Region: PLN02565 251221001957 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 251221001958 dimer interface [polypeptide binding]; other site 251221001959 pyridoxal 5'-phosphate binding site [chemical binding]; other site 251221001960 catalytic residue [active] 251221001961 Phosphate acetyl/butaryl transferase; Region: PTA_PTB; cl00390 251221001962 Queuine tRNA-ribosyltransferase; Region: TGT; cl00409 251221001963 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 251221001964 Helix-turn-helix domains; Region: HTH; cl00088 251221001965 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 251221001966 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 251221001967 Periplasmic sugar-binding domain of uncharacterized ABC-type transport systems; Region: PBP1_ABC_sugar_binding_like_12; cd06322 251221001968 putative ligand binding site [chemical binding]; other site 251221001969 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 251221001970 This family represents the domain I of the carbohydrate uptake proteins that transport only monosaccharides (Monos). The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and hexoses...; Region: ABC_Carb_Monos_I; cd03216 251221001971 Walker A/P-loop; other site 251221001972 ATP binding site [chemical binding]; other site 251221001973 Q-loop/lid; other site 251221001974 ABC transporter signature motif; other site 251221001975 Walker B; other site 251221001976 D-loop; other site 251221001977 H-loop/switch region; other site 251221001978 This family represents domain II of the carbohydrate uptake proteins that transport only monosaccharides (Monos). The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and hexoses; Region: ABC_Carb_Monos_II; cd03215 251221001979 Fe-S oxidoreductase [Energy production and conversion]; Region: COG1032 251221001980 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 251221001981 B12 binding site [chemical binding]; other site 251221001982 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 251221001983 FeS/SAM binding site; other site 251221001984 Plasmid stabilisation system protein; Region: Plasmid_stabil; cl11422 251221001985 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 251221001986 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 251221001987 The C-terminal domain of a subfamily of Na+ /H+ antiporter existed in bacteria and archea . Na+/H+ exchange proteins eject protons from cells, effectively eliminating excess acid from actively metabolising cells. Na+ /H+ exchange activity is also crucial...; Region: Na_H_Antiporter_C; cd01988 251221001988 Ligand Binding Site [chemical binding]; other site 251221001989 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 251221001990 Ligand Binding Site [chemical binding]; other site 251221001991 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 251221001992 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 251221001993 active site 251221001994 phosphorylation site [posttranslational modification] 251221001995 intermolecular recognition site; other site 251221001996 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 251221001997 DNA binding residues [nucleotide binding] 251221001998 dimerization interface [polypeptide binding]; other site 251221001999 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: VicK; COG5002 251221002000 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 251221002001 dimer interface [polypeptide binding]; other site 251221002002 phosphorylation site [posttranslational modification] 251221002003 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 251221002004 ATP binding site [chemical binding]; other site 251221002005 Mg2+ binding site [ion binding]; other site 251221002006 G-X-G motif; other site 251221002007 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 251221002008 Diaminopimelate epimerase; Region: DAP_epimerase; cl14668 251221002009 Diaminopimelate epimerase; Region: DAP_epimerase; cl14668 251221002010 tellurium resistance terB-like protein; Region: terB_like; cd07177 251221002011 metal binding site [ion binding]; metal-binding site 251221002012 Protein of unknown function DUF262; Region: DUF262; cl14890 251221002013 Protein of unknown function DUF262; Region: DUF262; cl14890 251221002014 Protein of unknown function DUF262; Region: DUF262; cl14890 251221002015 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl12011 251221002016 O-Antigen ligase; Region: Wzy_C; cl04850 251221002017 Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618 251221002018 DHH family; Region: DHH; pfam01368 251221002019 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 251221002020 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 251221002021 putative active site [active] 251221002022 VPS10 domain; Region: VPS10; smart00602 251221002023 Sialidases or neuraminidases function to bind and hydrolyze terminal sialic acid residues from various glycoconjugates as well as playing roles in pathogenesis, bacterial nutrition and cellular interactions. They have a six-bladed, beta-propeller fold...; Region: Sialidase; cd00260 251221002024 Asp-box motif; other site 251221002025 VPS10 domain; Region: VPS10; smart00602 251221002026 Ribosomal L27 protein; Region: Ribosomal_L27; cl00359 251221002027 Ribosomal prokaryotic L21 protein; Region: Ribosomal_L21p; cl00382 251221002028 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4398 251221002029 FIST N domain; Region: FIST; cl10701 251221002030 FIST C domain; Region: FIST_C; pfam10442 251221002031 Phosphoribosyl transferase domain; Region: Pribosyltran; cl00309 251221002032 Ribosomal protein L19; Region: Ribosomal_L19; cl00406 251221002033 SecE/Sec61-gamma subunits of protein translocation complex; Region: SecE; cl00481 251221002034 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 251221002035 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 251221002036 putative homodimer interface [polypeptide binding]; other site 251221002037 KOW motif; Region: KOW; cl00354 251221002038 Preprotein translocase SecG subunit; Region: SecG; cl09123 251221002039 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 251221002040 IHF dimer interface [polypeptide binding]; other site 251221002041 IHF - DNA interface [nucleotide binding]; other site 251221002042 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 251221002043 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 251221002044 Peptidase family M23; Region: Peptidase_M23; pfam01551 251221002045 cryptochrome, DASH family; Region: crypto_DASH; TIGR02765 251221002046 DNA photolyase; Region: DNA_photolyase; pfam00875 251221002047 FAD binding domain of DNA photolyase; Region: FAD_binding_7; pfam03441 251221002048 Predicted oxidoreductases (related to aryl-alcohol dehydrogenases) [Energy production and conversion]; Region: Tas; COG0667 251221002049 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 251221002050 active site 251221002051 catalytic tetrad [active] 251221002052 ferrochelatase; Reviewed; Region: hemH; PRK00035 251221002053 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 251221002054 C-terminal domain interface [polypeptide binding]; other site 251221002055 active site 251221002056 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 251221002057 active site 251221002058 N-terminal domain interface [polypeptide binding]; other site 251221002059 Dihaem cytochrome c; Region: DHC; pfam09626 251221002060 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; cl11587 251221002061 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_8; cd07817 251221002062 putative hydrophobic ligand binding site [chemical binding]; other site 251221002063 PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881 251221002064 oligomeric interface; other site 251221002065 putative active site [active] 251221002066 homodimer interface [polypeptide binding]; other site 251221002067 Ribbon-helix-helix protein, copG family; Region: RHH_1; cl15375 251221002068 L-aspartate oxidase; Provisional; Region: PRK07395 251221002069 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 251221002070 domain; Region: Succ_DH_flav_C; pfam02910 251221002071 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 251221002072 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 251221002073 active site 251221002074 (T/H)XGH motif; other site 251221002075 Protein of unknown function (DUF1230); Region: DUF1230; pfam06799 251221002076 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 251221002077 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 251221002078 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 251221002079 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 251221002080 active site 251221002081 HIGH motif; other site 251221002082 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 251221002083 KMSKS motif; other site 251221002084 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 251221002085 dihydropteroate synthase-related protein; Region: TIGR00284 251221002086 Rubredoxin [Energy production and conversion]; Region: COG1773 251221002087 Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730 251221002088 iron binding site [ion binding]; other site 251221002089 Ycf48-like protein; Provisional; Region: PRK13684 251221002090 cytochrome b559 subunit alpha; Provisional; Region: psbE; PRK02557 251221002091 Cytochrome b559, alpha (gene psbE) and beta (gene psbF)subunits; Region: Cytochrom_B559; cl02834 251221002092 Lumenal portion of Cytochrome b559, alpha (gene psbE) subunit; Region: Cytochrom_B559a; pfam00284 251221002093 Cytochrome b559, alpha (gene psbE) and beta (gene psbF)subunits; Region: Cytochrom_B559; cl02834 251221002094 PsbL protein; Region: PsbL; cl03581 251221002095 PsbJ; Region: PsbJ; cl09469 251221002096 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 251221002097 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 251221002098 active site 251221002099 phosphorylation site [posttranslational modification] 251221002100 intermolecular recognition site; other site 251221002101 dimerization interface [polypeptide binding]; other site 251221002102 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 251221002103 DNA binding site [nucleotide binding] 251221002104 heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386 251221002105 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 251221002106 dimerization interface [polypeptide binding]; other site 251221002107 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 251221002108 dimer interface [polypeptide binding]; other site 251221002109 phosphorylation site [posttranslational modification] 251221002110 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 251221002111 ATP binding site [chemical binding]; other site 251221002112 Mg2+ binding site [ion binding]; other site 251221002113 G-X-G motif; other site 251221002114 Uncharacterized conserved protein [Function unknown]; Region: COG3391 251221002115 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 251221002116 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 251221002117 Domain of unknown function (DUF305); Region: DUF305; pfam03713 251221002118 CHRD domain; Region: CHRD; cl06473 251221002119 A/G-specific DNA glycosylase [DNA replication, recombination, and repair]; Region: MutY; COG1194 251221002120 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 251221002121 minor groove reading motif; other site 251221002122 helix-hairpin-helix signature motif; other site 251221002123 substrate binding pocket [chemical binding]; other site 251221002124 active site 251221002125 Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; cl15304 251221002126 DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431 251221002127 DNA binding and oxoG recognition site [nucleotide binding] 251221002128 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 251221002129 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 251221002130 The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425 251221002131 active site 251221002132 8-oxo-dGMP binding site [chemical binding]; other site 251221002133 nudix motif; other site 251221002134 metal binding site [ion binding]; metal-binding site 251221002135 cobaltochelatase subunit; Region: Cob-chelat-sub; TIGR02442 251221002136 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 251221002137 Magnesium chelatase: Mg-chelatase catalyses the insertion of Mg into protoporphyrin IX (Proto). In chlorophyll biosynthesis, insertion of Mg2+ into protoporphyrin IX is catalysed by magnesium chelatase in an ATP-dependent reaction. Magnesium chelatase is...; Region: vWA_Magnesium_chelatase; cd01451 251221002138 metal ion-dependent adhesion site (MIDAS); other site 251221002139 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 251221002140 putative active site [active] 251221002141 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 251221002142 FOG: Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3385 251221002143 Protein of unknown function (DUF2996); Region: DUF2996; pfam11210 251221002144 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 251221002145 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 251221002146 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 251221002147 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 251221002148 dimerization interface [polypeptide binding]; other site 251221002149 putative DNA binding site [nucleotide binding]; other site 251221002150 putative Zn2+ binding site [ion binding]; other site 251221002151 Coenzyme F420-reducing hydrogenase, beta subunit [Energy production and conversion]; Region: FrhB; COG1035 251221002152 Coenzyme F420 hydrogenase/dehydrogenase, beta subunit N-term; Region: FrhB_FdhB_N; pfam04422 251221002153 Coenzyme F420 hydrogenase/dehydrogenase, beta subunit C terminus; Region: FrhB_FdhB_C; pfam04432 251221002154 oxaloacetate decarboxylase; Provisional; Region: PRK12331 251221002155 Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937 251221002156 active site 251221002157 catalytic residues [active] 251221002158 metal binding site [ion binding]; metal-binding site 251221002159 homodimer binding site [polypeptide binding]; other site 251221002160 Conserved carboxylase domain; Region: PYC_OADA; pfam02436 251221002161 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 251221002162 catalytic residues [active] 251221002163 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 251221002164 tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335; cl15440 251221002165 tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335; cl15440 251221002166 Protein of unknown function (DUF2488); Region: Ycf54; pfam10674 251221002167 para-aminobenzoate synthase component II; Provisional; Region: PRK08857 251221002168 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 251221002169 glutamine binding [chemical binding]; other site 251221002170 catalytic triad [active] 251221002171 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 251221002172 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 251221002173 Alpha/beta hydrolase of unknown function (DUF1400); Region: DUF1400; pfam07176 251221002174 Predicted dienelactone hydrolase [General function prediction only]; Region: COG4188 251221002175 isoform II; Region: PAF-AH_p_II; pfam03403 251221002176 radical SAM/Cys-rich domain protein; Region: rSAM_SeCys; TIGR04167 251221002177 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 251221002178 FeS/SAM binding site; other site 251221002179 Protein of unknown function (DUF3641); Region: DUF3641; pfam12345 251221002180 nicotinate-nucleotide pyrophosphorylase; Provisional; Region: PRK07428 251221002181 Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572 251221002182 dimerization interface [polypeptide binding]; other site 251221002183 active site 251221002184 tRNA (Guanine-1)-methyltransferase; Region: tRNA_m1G_MT; cl00407 251221002185 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl15260 251221002186 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 251221002187 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 251221002188 Family description; Region: VCBS; pfam13517 251221002189 Family description; Region: VCBS; pfam13517 251221002190 Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as Transcription factor ImmunoGlobin (TIG) domains. They are present in intracellular transcription factors, cell surface receptors (such as plexins and scatter factor...; Region: IPT; cl15674 251221002191 PQQ-dependent catabolism-associated beta-propeller protein; Region: PQQ_ABC_repeats; TIGR03866 251221002192 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4222 251221002193 putative transposase OrfB; Reviewed; Region: PHA02517 251221002194 Family description; Region: VCBS; pfam13517 251221002195 Family description; Region: VCBS; pfam13517 251221002196 Outer membrane receptor for ferrienterochelin and colicins [Inorganic ion transport and metabolism]; Region: FepA; COG4771 251221002197 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 251221002198 N-terminal plug; other site 251221002199 ligand-binding site [chemical binding]; other site 251221002200 CHAD domain; Region: CHAD; cl10506 251221002201 phage shock protein A; Region: phageshock_pspA; TIGR02977 251221002202 Zinc-dependent metalloprotease, pappalysin_like subfamily. The pregnancy-associated plasma protein A (PAPP-A or pappalysin-1) cleaves insulin-like growth factor-binding proteins 4 and 5, thereby promoting cell growth by releasing bound growth factor; Region: ZnMc_pappalysin_like; cd04275 251221002203 active site 251221002204 Integral membrane protein DUF92; Region: DUF92; cl00793 251221002205 Phosphoribosyl transferase domain; Region: Pribosyltran; cl00309 251221002206 ribose-phosphate pyrophosphokinase; Region: PLN02369 251221002207 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 251221002208 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 251221002209 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 251221002210 Ribosomal protein S19; Region: Ribosomal_S19; cl00350 251221002211 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 251221002212 structural tetrad; other site 251221002213 Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_2; cd03139 251221002214 conserved cys residue [active] 251221002215 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 251221002216 putative active site [active] 251221002217 tryptophan tryptophylquinone biosynthesis enzyme MauG; Region: TTQ_mauG; TIGR03791 251221002218 L,D-transpeptidase catalytic domain; Region: YkuD; cl15405 251221002219 benzoate transport; Region: 2A0115; TIGR00895 251221002220 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 251221002221 putative substrate translocation pore; other site 251221002222 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 251221002223 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 251221002224 Catalytic domain of Protein Kinases; Region: PKc; cd00180 251221002225 active site 251221002226 ATP binding site [chemical binding]; other site 251221002227 substrate binding site [chemical binding]; other site 251221002228 activation loop (A-loop); other site 251221002229 TolB amino-terminal domain; Region: TolB_N; cl00639 251221002230 Protein of unknown function, DUF1537; Region: DUF1537; cl01345 251221002231 Secretin and TonB N terminus short domain; Region: STN; cl06624 251221002232 type IV pilus secretin (or competence protein) PilQ; Region: IV_pilus_PilQ; TIGR02515 251221002233 Secretin and TonB N terminus short domain; Region: STN; cl06624 251221002234 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 251221002235 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 251221002236 Type II/IV secretion system protein; Region: GSPII_E; pfam00437 251221002237 PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129 251221002238 Walker A motif; other site 251221002239 ATP binding site [chemical binding]; other site 251221002240 Walker B motif; other site 251221002241 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 251221002242 ligand binding site [chemical binding]; other site 251221002243 flexible hinge region; other site 251221002244 Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain [Transcription / Signal transduction mechanisms]; Region: PspF; COG1221 251221002245 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 251221002246 Polyferredoxin [Energy production and conversion]; Region: NapH; COG0348 251221002247 4Fe-4S binding domain; Region: Fer4_5; pfam12801 251221002248 4Fe-4S binding domain; Region: Fer4_5; pfam12801 251221002249 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 251221002250 putative active site [active] 251221002251 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_4; cd04511 251221002252 nudix motif; other site 251221002253 PCD_DCoH: The bifunctional protein pterin-4alpha-carbinolamine dehydratase (PCD), also known as DCoH (dimerization cofactor of hepatocyte nuclear factor-1), is both a transcription activator and a metabolic enzyme. DCoH stimulates gene expression by...; Region: PCD_DCoH_subfamily_a; cd00913 251221002254 aromatic arch; other site 251221002255 DCoH dimer interaction site [polypeptide binding]; other site 251221002256 DCoH /HNF-1 dimer interaction site [polypeptide binding]; other site 251221002257 DCoH tetramer interaction site [polypeptide binding]; other site 251221002258 substrate binding site [chemical binding]; other site 251221002259 Psb28 protein; Region: Psb28; cl04326 251221002260 Protein Kinase C Interacting protein related (PKCI): PKCI and related proteins belong to the ubiquitous HIT family of hydrolases that act on alpha-phosphates of ribonucleotides. The members of this subgroup have a conserved HxHxHxx motif (x is a...; Region: PKCI_related; cd01276 251221002261 nucleotide binding site/active site [active] 251221002262 HIT family signature motif; other site 251221002263 catalytic residue [active] 251221002264 Uncharacterized conserved protein [Function unknown]; Region: COG2006 251221002265 Domain of unknown function (DUF362); Region: DUF362; pfam04015 251221002266 Predicted permeases [General function prediction only]; Region: COG0795; cl12074 251221002267 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 251221002268 glycogen synthase; Provisional; Region: glgA; PRK00654 251221002269 This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791 251221002270 ADP-binding pocket [chemical binding]; other site 251221002271 homodimer interface [polypeptide binding]; other site 251221002272 Ion channel; Region: Ion_trans_2; cl11596 251221002273 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 251221002274 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 251221002275 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl15357 251221002276 N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854 251221002277 active site 251221002278 dimer interface [polypeptide binding]; other site 251221002279 NIL domain; Region: NIL; cl09633 251221002280 4Fe-4S binding domain; Region: Fer4; cl02805 251221002281 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 251221002282 4Fe-4S binding domain; Region: Fer4; cl02805 251221002283 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 251221002284 putative active site [active] 251221002285 Mechanosensitive ion channel; Region: MS_channel; pfam00924 251221002286 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 251221002287 Peptidase family U32; Region: Peptidase_U32; cl03113 251221002288 Collagenase; Region: DUF3656; pfam12392 251221002289 Peptidase family U32; Region: Peptidase_U32; cl03113 251221002290 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 251221002291 L-iditol 2-dehydrogenase; Region: iditol_2_DH_like; cd08235 251221002292 putative NAD(P) binding site [chemical binding]; other site 251221002293 catalytic Zn binding site [ion binding]; other site 251221002294 Uncharacterised protein family (UPF0104); Region: UPF0104; cl04219 251221002295 Protein of unknown function (DUF2811); Region: DUF2811; pfam10929 251221002296 protoporphyrinogen oxidase; Region: proto_IX_ox; TIGR00562 251221002297 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 251221002298 UTRA domain; Region: UTRA; cl01230 251221002299 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeC; cd03378 251221002300 active site clefts [active] 251221002301 zinc binding site [ion binding]; other site 251221002302 dimer interface [polypeptide binding]; other site 251221002303 MBOAT family; Region: MBOAT; cl00738 251221002304 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 251221002305 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 251221002306 peptide binding site [polypeptide binding]; other site 251221002307 Phycobilisome Linker polypeptide; Region: PBS_linker_poly; pfam00427 251221002308 Protein of unknown function (DUF2656); Region: DUF2656; pfam10847 251221002309 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_8; cd07246 251221002310 putative dimer interface [polypeptide binding]; other site 251221002311 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 251221002312 Family description; Region: VCBS; pfam13517 251221002313 Fatty acyltransferase-like subfamily of the SGNH hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its...; Region: fatty_acyltransferase_like; cd01846 251221002314 active site 251221002315 catalytic triad [active] 251221002316 oxyanion hole [active] 251221002317 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 251221002318 Predicted dinucleotide-binding enzymes [General function prediction only]; Region: COG2085 251221002319 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 251221002320 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 251221002321 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 251221002322 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 251221002323 [2Fe-2S] cluster binding site [ion binding]; other site 251221002324 C-terminal catalytic domain of the oxygenase alpha subunit of Rieske-type non-heme iron aromatic ring-hydroxylating oxygenases; Region: RHO_alpha_C; cd00680 251221002325 alpha subunit interface [polypeptide binding]; other site 251221002326 active site 251221002327 substrate binding site [chemical binding]; other site 251221002328 Fe binding site [ion binding]; other site 251221002329 urea carboxylase; Region: urea_carbox; TIGR02712 251221002330 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 251221002331 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087 251221002332 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; cl08365 251221002333 Allophanate hydrolase subunit 2; Region: AHS2; cl00865 251221002334 Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; cl00896 251221002335 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 251221002336 carboxyltransferase (CT) interaction site; other site 251221002337 biotinylation site [posttranslational modification]; other site 251221002338 Domain of unknown function (DUF1989); Region: DUF1989; cl01474 251221002339 Domain of unknown function (DUF1989); Region: DUF1989; cl01474 251221002340 allophanate hydrolase; Provisional; Region: PRK08186 251221002341 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cl11426 251221002342 Carbohydrate-selective porin, OprB family; Region: OprB; pfam04966 251221002343 Localisation of periplasmic protein complexes; Region: AMIN; pfam11741 251221002344 Localisation of periplasmic protein complexes; Region: AMIN; pfam11741 251221002345 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 251221002346 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 251221002347 active site 251221002348 metal binding site [ion binding]; metal-binding site 251221002349 Lipocalin / cytosolic fatty-acid binding protein family; Region: Lipocalin; cl01150 251221002350 Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004 251221002351 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 251221002352 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 251221002353 Pyridoxal phosphate biosynthetic protein PdxA; Region: PdxA; cl00873 251221002354 4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK03743 251221002355 L,D-transpeptidase catalytic domain; Region: YkuD; cl15405 251221002356 Flagellin N-methylase; Region: FliB; cl00497 251221002357 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cl00197 251221002358 active site 251221002359 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 251221002360 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 251221002361 MAEBL; Provisional; Region: PTZ00121 251221002362 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 251221002363 active site 251221002364 NTP binding site [chemical binding]; other site 251221002365 metal binding triad [ion binding]; metal-binding site 251221002366 HEPN domain; Region: HEPN; cl00824 251221002367 Transglutaminase-like superfamily; Region: Transglut_core; cl10469 251221002368 NdvC_like proteins in this family are putative bacterial beta-(1,6)-glucosyltransferase; Region: CESA_NdvC_like; cd06435 251221002369 Ligand binding site; other site 251221002370 DXD motif; other site 251221002371 FOG: HEAT repeat [Energy production and conversion]; Region: COG1413 251221002372 Tubulin like; Region: Tubulin_2; pfam13809 251221002373 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 251221002374 Family description; Region: VCBS; pfam13517 251221002375 Family description; Region: VCBS; pfam13517 251221002376 Transposase; Region: DDE_Tnp_ISL3; pfam01610 251221002377 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 251221002378 30S ribosomal protein S1; Reviewed; Region: PRK07400 251221002379 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 251221002380 RNA binding site [nucleotide binding]; other site 251221002381 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 251221002382 RNA binding site [nucleotide binding]; other site 251221002383 S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists of...; Region: S1_RPS1_repeat_ec3; cd05688 251221002384 RNA binding site [nucleotide binding]; other site 251221002385 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II/unknown domain fusion protein; Provisional; Region: PRK09319 251221002386 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; cl00336 251221002387 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 251221002388 dimerization interface [polypeptide binding]; other site 251221002389 active site 251221002390 Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr; Region: PTPc; cl00053 251221002391 active site 251221002392 Monoamine oxidase [Amino acid transport and metabolism]; Region: COG1231 251221002393 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 251221002394 Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP; cd07040 251221002395 catalytic core [active] 251221002396 Phage integrase family; Region: Phage_integrase; pfam00589 251221002397 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 251221002398 DNA binding site [nucleotide binding] 251221002399 Int/Topo IB signature motif; other site 251221002400 active site 251221002401 catalytic residues [active] 251221002402 Family description; Region: VCBS; pfam13517 251221002403 Family description; Region: VCBS; pfam13517 251221002404 Family description; Region: VCBS; pfam13517 251221002405 Family description; Region: VCBS; pfam13517 251221002406 Family description; Region: VCBS; pfam13517 251221002407 Family description; Region: VCBS; pfam13517 251221002408 Family description; Region: VCBS; pfam13517 251221002409 Family description; Region: VCBS; pfam13517 251221002410 Family description; Region: VCBS; pfam13517 251221002411 Family description; Region: VCBS; pfam13517 251221002412 Family description; Region: VCBS; pfam13517 251221002413 Family description; Region: VCBS; pfam13517 251221002414 Family description; Region: VCBS; pfam13517 251221002415 Family description; Region: VCBS; pfam13517 251221002416 putative phosphoketolase; Provisional; Region: PRK05261 251221002417 Thiamine pyrophosphate (TPP) family, Phosphoketolase (PK) subfamily, TPP-binding module; PK catalyzes the conversion of D-xylulose 5-phosphate and phosphate to acetyl phosphate, D-glyceraldehyde-3-phosphate and H2O. This enzyme requires divalent...; Region: TPP_PK; cd02011 251221002418 TPP-binding site; other site 251221002419 Pyrimidine (PYR) binding domain of thiamine pyrophosphate (TPP)-dependent enzymes; Region: TPP_enzyme_PYR; cl11410 251221002420 XFP C-terminal domain; Region: XFP_C; pfam09363 251221002421 This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300 251221002422 homodimer interface [polypeptide binding]; other site 251221002423 glycogen/starch/alpha-glucan phosphorylases; Region: P_ylase; TIGR02093 251221002424 active site pocket [active] 251221002425 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 251221002426 catalytic core [active] 251221002427 Acetokinase family; Region: Acetate_kinase; cl01029 251221002428 Helix-turn-helix domains; Region: HTH; cl00088 251221002429 aminoethylphosphonate catabolism associated LysR family transcriptional regulator; Region: phn_lysR; TIGR03339 251221002430 The C-terminal substrate binding of LysR-type transcriptional regulator (CbbR) of RubisCO operon, which is involved in the carbon dioxide fixation, contains the type 2 periplasmic binding fold; Region: PBP2_CbbR_RubisCO_like; cd08419 251221002431 putative dimerization interface [polypeptide binding]; other site 251221002432 NAD(P)H-quinone oxidoreductase subunit F; Validated; Region: PRK07390 251221002433 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; cl14187 251221002434 proton-translocating NADH-quinone oxidoreductase, chain M; Region: NDH_I_M; TIGR01972 251221002435 CO2 hydration protein (ChpXY); Region: ChpXY; cl10905 251221002436 Fasciclin domain; Region: Fasciclin; cl02663 251221002437 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 251221002438 putative active site [active] 251221002439 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 251221002440 putative active site [active] 251221002441 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 251221002442 S-adenosylmethionine binding site [chemical binding]; other site 251221002443 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 251221002444 ABC Carbohydrate and Solute Transporters-like subgroup. This family is comprised of proteins involved in the transport of apparently unrelated solutes and proteins specific for di- and oligosaccharides and polyols. ABC transporters are a large family...; Region: ABC_Carb_Solutes_like; cd03259 251221002445 Walker A/P-loop; other site 251221002446 ATP binding site [chemical binding]; other site 251221002447 Q-loop/lid; other site 251221002448 ABC transporter signature motif; other site 251221002449 Walker B; other site 251221002450 D-loop; other site 251221002451 H-loop/switch region; other site 251221002452 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 251221002453 dimer interface [polypeptide binding]; other site 251221002454 conserved gate region; other site 251221002455 putative PBP binding loops; other site 251221002456 ABC-ATPase subunit interface; other site 251221002457 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 251221002458 dimer interface [polypeptide binding]; other site 251221002459 conserved gate region; other site 251221002460 putative PBP binding loops; other site 251221002461 ABC-ATPase subunit interface; other site 251221002462 ABC-type thiamine transport system, periplasmic component [Coenzyme metabolism]; Region: TbpA; COG4143 251221002463 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 251221002464 CHASE3 domain; Region: CHASE3; cl05000 251221002465 PAS fold; Region: PAS_4; pfam08448 251221002466 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 251221002467 putative active site [active] 251221002468 heme pocket [chemical binding]; other site 251221002469 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 251221002470 dimer interface [polypeptide binding]; other site 251221002471 phosphorylation site [posttranslational modification] 251221002472 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 251221002473 ATP binding site [chemical binding]; other site 251221002474 Mg2+ binding site [ion binding]; other site 251221002475 G-X-G motif; other site 251221002476 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 251221002477 Response regulator receiver domain; Region: Response_reg; pfam00072 251221002478 active site 251221002479 phosphorylation site [posttranslational modification] 251221002480 intermolecular recognition site; other site 251221002481 dimerization interface [polypeptide binding]; other site 251221002482 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 251221002483 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 251221002484 active site 251221002485 phosphorylation site [posttranslational modification] 251221002486 intermolecular recognition site; other site 251221002487 dimerization interface [polypeptide binding]; other site 251221002488 aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874 251221002489 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 251221002490 Semialdehyde dehydrogenase, dimerisation domain; Region: Semialdhyde_dhC; pfam02774 251221002491 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 251221002492 dihydrodipicolinate synthase; Region: dapA; TIGR00674 251221002493 dimer interface [polypeptide binding]; other site 251221002494 active site 251221002495 catalytic residue [active] 251221002496 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 251221002497 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 251221002498 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 251221002499 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 251221002500 DNA topoisomerase I, bacterial; Region: topA_bact; TIGR01051 251221002501 active site 251221002502 interdomain interaction site; other site 251221002503 putative metal-binding site [ion binding]; other site 251221002504 nucleotide binding site [chemical binding]; other site 251221002505 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 251221002506 domain I; other site 251221002507 DNA binding groove [nucleotide binding] 251221002508 phosphate binding site [ion binding]; other site 251221002509 domain II; other site 251221002510 domain III; other site 251221002511 nucleotide binding site [chemical binding]; other site 251221002512 catalytic site [active] 251221002513 domain IV; other site 251221002514 allantoate amidohydrolase; Reviewed; Region: PRK09290 251221002515 Protein of unknown function DUF262; Region: DUF262; cl14890 251221002516 hypothetical protein; Provisional; Region: PRK09133 251221002517 magnesium Mg(2+) and cobalt Co(2+) transport protein (corA); Region: corA; TIGR00383 251221002518 magnesium/nickel/cobalt transporter CorA; Provisional; Region: PRK11085; cl00459 251221002519 CpeS-like protein; Region: CpeS; pfam09367 251221002520 DhnA-type fructose-1,6-bisphosphate aldolase and related enzymes [Carbohydrate transport and metabolism]; Region: FbaB; COG1830 251221002521 Class I fructose-1,6-bisphosphate (FBP) aldolases of the archaeal type (DhnA homologs); Region: DhnA; cd00958 251221002522 putative active site; other site 251221002523 catalytic residue [active] 251221002524 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 251221002525 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 251221002526 ring oligomerisation interface [polypeptide binding]; other site 251221002527 ATP/Mg binding site [chemical binding]; other site 251221002528 stacking interactions; other site 251221002529 hinge regions; other site 251221002530 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 251221002531 oligomerisation interface [polypeptide binding]; other site 251221002532 mobile loop; other site 251221002533 roof hairpin; other site 251221002534 lipoyl synthase; Provisional; Region: PRK05481 251221002535 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 251221002536 FeS/SAM binding site; other site 251221002537 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 251221002538 putative active site [active] 251221002539 DNA mismatch repair protein MutS; Provisional; Region: PRK05399 251221002540 MutS domain I; Region: MutS_I; pfam01624 251221002541 MutS domain II; Region: MutS_II; pfam05188 251221002542 MutS family domain IV; Region: MutS_IV; pfam05190 251221002543 MutS1 homolog in eukaryotes. The MutS protein initiates DNA mismatch repair by recognizing mispaired and unpaired bases embedded in duplex DNA and activating endo- and exonucleases to remove the mismatch. Members of the MutS family possess C-terminal...; Region: ABC_MutS1; cd03284 251221002544 Walker A/P-loop; other site 251221002545 ATP binding site [chemical binding]; other site 251221002546 Q-loop/lid; other site 251221002547 ABC transporter signature motif; other site 251221002548 Walker B; other site 251221002549 D-loop; other site 251221002550 H-loop/switch region; other site 251221002551 Leucyl/phenylalanyl-tRNA protein transferase; Region: Leu_Phe_trans; cl01006 251221002552 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 251221002553 3-phosphoshikimate 1-carboxyvinyltransferase; Region: aroA; TIGR01356 251221002554 hinge; other site 251221002555 active site 251221002556 Protein of unknown function (DUF3353); Region: DUF3353; pfam11833 251221002557 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 251221002558 substrate binding site [chemical binding]; other site 251221002559 dimer interface [polypeptide binding]; other site 251221002560 catalytic triad [active] 251221002561 Psb28 protein; Region: Psb28; cl04326 251221002562 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 251221002563 homopentamer interface [polypeptide binding]; other site 251221002564 active site 251221002565 Protein of unknown function (DUF2555); Region: DUF2555; pfam10742 251221002566 Deoxyhypusine synthase; Region: DS; cl00826 251221002567 PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812 251221002568 putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737 251221002569 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 251221002570 FMN binding site [chemical binding]; other site 251221002571 active site 251221002572 catalytic residues [active] 251221002573 substrate binding site [chemical binding]; other site 251221002574 Domain of unknown function (DUF74); Region: DUF74; cl00426 251221002575 argininosuccinate lyase; Provisional; Region: PRK00855 251221002576 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 251221002577 active sites [active] 251221002578 tetramer interface [polypeptide binding]; other site 251221002579 glutamine synthetase, type I; Region: GlnA; TIGR00653 251221002580 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 251221002581 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 251221002582 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 251221002583 nucleoside/Zn binding site; other site 251221002584 dimer interface [polypeptide binding]; other site 251221002585 catalytic motif [active] 251221002586 Subtilisin-like serine proteases [Posttranslational modification, protein turnover, chaperones]; Region: AprE; COG1404 251221002587 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 251221002588 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 251221002589 catalytic residues [active] 251221002590 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 251221002591 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cl15358 251221002592 Family description; Region: VCBS; pfam13517 251221002593 Family description; Region: VCBS; pfam13517 251221002594 Family description; Region: VCBS; pfam13517 251221002595 Family description; Region: VCBS; pfam13517 251221002596 Family description; Region: VCBS; pfam13517 251221002597 Family description; Region: VCBS; pfam13517 251221002598 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 251221002599 binding surface 251221002600 TPR motif; other site 251221002601 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 251221002602 binding surface 251221002603 TPR motif; other site 251221002604 CHAT domain; Region: CHAT; cl02083 251221002605 Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004 251221002606 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 251221002607 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 251221002608 Predicted glycosyl transferase [General function prediction only]; Region: COG4671 251221002609 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 251221002610 Predicted glycosyl transferase [General function prediction only]; Region: COG4671 251221002611 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 251221002612 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 251221002613 This family is most closely related to the GT1 family of glycosyltransferases. wlbH in Bordetella parapertussis has been shown to be required for the biosynthesis of a trisaccharide that, when attached to the B. pertussis lipopolysaccharide (LPS) core; Region: GT1_wlbH_like; cd03798 251221002614 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 251221002615 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 251221002616 active site 251221002617 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 251221002618 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 251221002619 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 251221002620 Walker A/P-loop; other site 251221002621 ATP binding site [chemical binding]; other site 251221002622 Q-loop/lid; other site 251221002623 ABC transporter signature motif; other site 251221002624 Walker B; other site 251221002625 D-loop; other site 251221002626 H-loop/switch region; other site 251221002627 UDP glucuronic acid epimerase, extended (e) SDRs; Region: UDP_GE_SDE_e; cd05253 251221002628 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 251221002629 putative NAD(P) binding site [chemical binding]; other site 251221002630 active site 251221002631 putative substrate binding site [chemical binding]; other site 251221002632 Carbohydrate-selective porin, OprB family; Region: OprB; pfam04966 251221002633 Protein required for attachment to host cells; Region: Host_attach; cl02398 251221002634 Ferredoxin thioredoxin reductase catalytic beta chain; Region: FeThRed_B; cl01977 251221002635 Large-conductance mechanosensitive channel, MscL; Region: MscL; cl00860 251221002636 folylpolyglutamate synthase/dihydrofolate synthase; Region: folC; TIGR01499 251221002637 acetyl coenzyme A synthetase (ADP forming), alpha domain; Region: AcCoA-syn-alpha; TIGR02717 251221002638 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 251221002639 Acyl-CoA synthetase (NDP forming) [Energy production and conversion]; Region: COG1042 251221002640 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 251221002641 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 251221002642 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 251221002643 Walker A/P-loop; other site 251221002644 ATP binding site [chemical binding]; other site 251221002645 Q-loop/lid; other site 251221002646 ABC transporter signature motif; other site 251221002647 Walker B; other site 251221002648 D-loop; other site 251221002649 H-loop/switch region; other site 251221002650 Peptidase family M48; Region: Peptidase_M48; cl12018 251221002651 bifunctional orotidine 5'-phosphate decarboxylase/orotate phosphoribosyltransferase protein; Validated; Region: PRK05500 251221002652 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase contains two...; Region: OMP_decarboxylase_like; cd04725 251221002653 active site 251221002654 dimer interface [polypeptide binding]; other site 251221002655 Phosphoribosyl transferase domain; Region: Pribosyltran; cl00309 251221002656 CHAD domain; Region: CHAD; cl10506 251221002657 Protein of unknown function (DUF2905); Region: DUF2905; pfam11146 251221002658 2'-5' RNA ligase [Translation, ribosomal structure and biogenesis]; Region: LigT; COG1514 251221002659 2',5' RNA ligase family; Region: 2_5_RNA_ligase; pfam02834 251221002660 PetM family of cytochrome b6f complex subunit 7; Region: PetM; cl15715 251221002661 ATP-sulfurylase; Region: ATPS; cd00517 251221002662 active site 251221002663 HXXH motif; other site 251221002664 flexible loop; other site 251221002665 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 251221002666 dimer interface [polypeptide binding]; other site 251221002667 ADP-ribose binding site [chemical binding]; other site 251221002668 active site 251221002669 nudix motif; other site 251221002670 metal binding site [ion binding]; metal-binding site 251221002671 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 251221002672 nudix motif; other site 251221002673 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_8; cd07817 251221002674 putative hydrophobic ligand binding site [chemical binding]; other site 251221002675 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 251221002676 active site residue [active] 251221002677 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_8; cd07817 251221002678 putative hydrophobic ligand binding site [chemical binding]; other site 251221002679 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 251221002680 active site residue [active] 251221002681 RNA polymerase sigma factor, TIGR02999 family; Region: Sig-70_X6 251221002682 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cl15358 251221002683 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 251221002684 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 251221002685 dimer interface [polypeptide binding]; other site 251221002686 active site 251221002687 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 251221002688 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 251221002689 E3 interaction surface; other site 251221002690 lipoyl attachment site [posttranslational modification]; other site 251221002691 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; cl02008 251221002692 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 251221002693 FOG: Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3385 251221002694 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_y; TIGR03182 251221002695 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 251221002696 tetramer interface [polypeptide binding]; other site 251221002697 TPP-binding site [chemical binding]; other site 251221002698 heterodimer interface [polypeptide binding]; other site 251221002699 phosphorylation loop region [posttranslational modification] 251221002700 Pyrimidine (PYR) binding domain of thiamine pyrophosphate (TPP)-dependent enzymes; Region: TPP_enzyme_PYR; cl11410 251221002701 PYR/PP interface [polypeptide binding]; other site 251221002702 dimer interface [polypeptide binding]; other site 251221002703 TPP binding site [chemical binding]; other site 251221002704 Bacterial transcriptional activator domain; Region: BTAD; smart01043 251221002705 Catalytic domain of Protein Kinases; Region: PKc; cd00180 251221002706 active site 251221002707 ATP binding site [chemical binding]; other site 251221002708 substrate binding site [chemical binding]; other site 251221002709 activation loop (A-loop); other site 251221002710 TolB amino-terminal domain; Region: TolB_N; cl00639 251221002711 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 251221002712 binding surface 251221002713 TPR motif; other site 251221002714 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 251221002715 TPR motif; other site 251221002716 binding surface 251221002717 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 251221002718 binding surface 251221002719 TPR motif; other site 251221002720 Putative Zn-dependent protease, contains TPR repeats [General function prediction only]; Region: COG4783 251221002721 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 251221002722 FAD binding domain; Region: FAD_binding_2; pfam00890 251221002723 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 251221002724 ligand binding site [chemical binding]; other site 251221002725 flexible hinge region; other site 251221002726 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 251221002727 putative active site [active] 251221002728 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 251221002729 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 251221002730 ligand binding site [chemical binding]; other site 251221002731 Cupin domain; Region: Cupin_2; cl09118 251221002732 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 251221002733 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 251221002734 S-adenosylmethionine binding site [chemical binding]; other site 251221002735 Cupin domain; Region: Cupin_2; cl09118 251221002736 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 251221002737 FOG: Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3385 251221002738 Cupin domain; Region: Cupin_2; cl09118 251221002739 Cupin superfamily protein; Region: Cupin_4; pfam08007 251221002740 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3514 251221002741 Protein of unknown function (DUF497); Region: DUF497; cl01108 251221002742 alpha-glucosidase; Provisional; Region: PRK10137 251221002743 Mannosyl oligosaccharide glucosidase; Region: Glyco_hydro_63; pfam03200 251221002744 glucose-1-dehydrogenase; Provisional; Region: PRK08936 251221002745 glucose 1 dehydrogenase (GlcDH), classical (c) SDRs; Region: GlcDH_SDR_c; cd05358 251221002746 NAD binding site [chemical binding]; other site 251221002747 homodimer interface [polypeptide binding]; other site 251221002748 active site 251221002749 Bacterial protein of unknown function (DUF924); Region: DUF924; cl01561 251221002750 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 251221002751 putative active site [active] 251221002752 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 251221002753 6-phosphogluconate dehydrogenase; Validated; Region: PRK09287 251221002754 6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393 251221002755 ThiC family; Region: ThiC; cl08031 251221002756 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 251221002757 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 251221002758 Walker A motif; other site 251221002759 ATP binding site [chemical binding]; other site 251221002760 Helix-turn-helix domains; Region: HTH; cl00088 251221002761 Uncharacterized enzyme of heme biosynthesis [Coenzyme metabolism]; Region: HemY; COG3071 251221002762 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 251221002763 TPR motif; other site 251221002764 binding surface 251221002765 Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG1672 251221002766 Protein of unknown function (DUF3532); Region: DUF3532; pfam12050 251221002767 malonyl-CoA synthase; Validated; Region: PRK07514 251221002768 Acyl-protein synthetase, LuxE; Region: LuxE; cl15695 251221002769 Flavin containing amine oxidoreductase; Region: Amino_oxidase; pfam01593 251221002770 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 251221002771 PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812 251221002772 Ribbon-helix-helix protein, copG family; Region: RHH_1; cl15375 251221002773 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 251221002774 putative active site [active] 251221002775 homoserine kinase; Provisional; Region: PRK01212 251221002776 GHMP kinases N terminal domain; Region: GHMP_kinases_N; cl08256 251221002777 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 251221002778 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 251221002779 motif II; other site 251221002780 YceG-like family; Region: YceG; pfam02618 251221002781 proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010 251221002782 dimerization interface [polypeptide binding]; other site 251221002783 Protein of unknown function (DUF3727); Region: DUF3727; pfam12527 251221002784 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD includes...; Region: RuvC_resolvase; cl00243 251221002785 Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334 251221002786 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 251221002787 NAD(P) binding domain of glutamate dehydrogenase, subgroup 1; Region: NAD_bind_1_Glu_DH; cd01076 251221002788 NAD(P) binding site [chemical binding]; other site 251221002789 Domain of unknown function (DUF3331); Region: DUF3331; pfam11811 251221002790 hypothetical protein; Provisional; Region: PRK07208 251221002791 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 251221002792 acetohydroxyacid synthase small subunit; Region: ilvH; CHL00100 251221002793 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 251221002794 putative valine binding site [chemical binding]; other site 251221002795 dimer interface [polypeptide binding]; other site 251221002796 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 251221002797 Biopolymer transport protein ExbD/TolR; Region: ExbD; cl00537 251221002798 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 251221002799 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cl00107 251221002800 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cl00107 251221002801 Peptidase family M23; Region: Peptidase_M23; pfam01551 251221002802 Outer membrane efflux protein; Region: OEP; pfam02321 251221002803 Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538 251221002804 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 251221002805 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 251221002806 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 251221002807 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07656 251221002808 Acyl-protein synthetase, LuxE; Region: LuxE; cl15695 251221002809 Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; cl04011 251221002810 CHASE2 domain; Region: CHASE2; cl01732 251221002811 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 251221002812 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 251221002813 Predicted ATPase [General function prediction only]; Region: COG4637 251221002814 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 251221002815 Walker A/P-loop; other site 251221002816 ATP binding site [chemical binding]; other site 251221002817 Q-loop/lid; other site 251221002818 Domain of unknown function (DUF4276); Region: DUF4276; pfam14103 251221002819 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 251221002820 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859 251221002821 pentapeptide MXKDX repeat protein; Region: penta_MxKDx; TIGR02953 251221002822 global nitrogen regulator NtcA, cyanobacterial; Region: NtcA_cyano; TIGR03697 251221002823 RNA polymerase sigma factor; Provisional; Region: PRK12519 251221002824 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 251221002825 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 251221002826 DNA binding residues [nucleotide binding] 251221002827 Anti-sigma-K factor rskA; Region: RskA; cl15366 251221002828 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 251221002829 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 251221002830 active site 251221002831 metal binding site [ion binding]; metal-binding site 251221002832 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 251221002833 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 251221002834 active site 251221002835 metal binding site [ion binding]; metal-binding site 251221002836 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cl00200 251221002837 amphipathic channel; other site 251221002838 Asn-Pro-Ala signature motifs; other site 251221002839 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 251221002840 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 251221002841 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 251221002842 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 251221002843 active site 251221002844 NTP binding site [chemical binding]; other site 251221002845 metal binding triad [ion binding]; metal-binding site 251221002846 antibiotic binding site [chemical binding]; other site 251221002847 Protein of unknown function DUF86; Region: DUF86; cl01031 251221002848 Chlorite dismutase; Region: Chlor_dismutase; cl01280 251221002849 Glucose dehydrogenase; Region: glucose_DH; cd08230 251221002850 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 251221002851 NADP binding site [chemical binding]; other site 251221002852 catalytic Zn binding site [ion binding]; other site 251221002853 structural Zn binding site [ion binding]; other site 251221002854 dimer interface [polypeptide binding]; other site 251221002855 Mannosyl oligosaccharide glucosidase; Region: Glyco_hydro_63; pfam03200 251221002856 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 251221002857 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 251221002858 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 251221002859 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 251221002860 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 251221002861 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 251221002862 Electron transfer DM13; Region: DM13; cl02735 251221002863 EamA-like transporter family; Region: EamA; cl01037 251221002864 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 251221002865 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 251221002866 structural tetrad; other site 251221002867 FOG: WD40 repeat [General function prediction only]; Region: COG2319 251221002868 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 251221002869 structural tetrad; other site 251221002870 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 251221002871 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 251221002872 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 251221002873 Starch synthase catalytic domain; Region: Glyco_transf_5; pfam08323 251221002874 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 251221002875 Predicted membrane protein [Function unknown]; Region: COG4083; cl15694 251221002876 CDP-tyvelose 2-epimerase, extended (e) SDRs; Region: CDP_TE_SDR_e; cd05258 251221002877 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 251221002878 NAD binding site [chemical binding]; other site 251221002879 homotetramer interface [polypeptide binding]; other site 251221002880 homodimer interface [polypeptide binding]; other site 251221002881 active site 251221002882 substrate binding site [chemical binding]; other site 251221002883 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 251221002884 S-adenosylmethionine binding site [chemical binding]; other site 251221002885 Phycobilisome protein; Region: Phycobilisome; cl08227 251221002886 CpeT/CpcT family (DUF1001); Region: CpeT; pfam06206 251221002887 Phycobilisome protein; Region: Phycobilisome; cl08227 251221002888 Phycobilisome protein; Region: Phycobilisome; cl08227 251221002889 FOG: HEAT repeat [Energy production and conversion]; Region: COG1413 251221002890 FOG: HEAT repeat [Energy production and conversion]; Region: COG1413 251221002891 Phycobilisome protein; Region: Phycobilisome; cl08227 251221002892 Phycobilisome protein; Region: Phycobilisome; cl08227 251221002893 CpeS-like protein; Region: CpeS; pfam09367 251221002894 CpeS-like protein; Region: CpeS; pfam09367 251221002895 CpeT/CpcT family (DUF1001); Region: CpeT; pfam06206 251221002896 Domain of unknown function (DUF1772); Region: DUF1772; cl12097 251221002897 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 251221002898 FOG: Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3385 251221002899 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 251221002900 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 251221002901 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; cl00562 251221002902 PhoD-like phosphatase; Region: PhoD; pfam09423 251221002903 Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389 251221002904 putative active site [active] 251221002905 putative metal binding site [ion binding]; other site 251221002906 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 251221002907 Protein of unknown function (DUF1778); Region: DUF1778; cl01845 251221002908 Acidobacterial duplicated orphan permease; Region: ADOP; TIGR03434 251221002909 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 251221002910 FtsX-like permease family; Region: FtsX; pfam02687 251221002911 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 251221002912 FtsX-like permease family; Region: FtsX; pfam02687 251221002913 Helix-turn-helix domains; Region: HTH; cl00088 251221002914 Periplasmic protease [Cell envelope biogenesis, outer membrane]; Region: Prc; COG0793 251221002915 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 251221002916 Surface antigen; Region: Surface_Ag_2; cl01155 251221002917 dihydrodipicolinate reductase; Provisional; Region: PRK00048 251221002918 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 251221002919 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 251221002920 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 251221002921 TPR motif; other site 251221002922 binding surface 251221002923 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 251221002924 binding surface 251221002925 TPR motif; other site 251221002926 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 251221002927 binding surface 251221002928 TPR motif; other site 251221002929 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 251221002930 binding surface 251221002931 TPR motif; other site 251221002932 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 251221002933 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cl01898 251221002934 Bacterial protein of unknown function (DUF885); Region: DUF885; pfam05960 251221002935 bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase protein; Reviewed; Region: PRK02759 251221002936 Phosphoribosyl-AMP cyclohydrolase; Region: PRA-CH; cl00344 251221002937 MazG nucleotide pyrophosphohydrolase domain; Region: MazG; cl00345 251221002938 RES domain; Region: RES; cl02411 251221002939 putative toxin-antitoxin system antitoxin component, TIGR02293 family; Region: TAS_TIGR02293 251221002940 Protein of unknown function (DUF2384); Region: DUF2384; pfam09722 251221002941 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 251221002942 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 251221002943 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 251221002944 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 251221002945 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 251221002946 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 251221002947 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 251221002948 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 251221002949 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 251221002950 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 251221002951 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 251221002952 hydrolase, alpha/beta fold family protein; Region: PLN02824 251221002953 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 251221002954 glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045 251221002955 NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213 251221002956 tRNA; other site 251221002957 putative tRNA binding site [nucleotide binding]; other site 251221002958 putative NADP binding site [chemical binding]; other site 251221002959 Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745 251221002960 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 251221002961 Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282 251221002962 Bacterial protein of unknown function (DUF885); Region: DUF885; pfam05960 251221002963 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 251221002964 ATP binding site [chemical binding]; other site 251221002965 Mg2+ binding site [ion binding]; other site 251221002966 G-X-G motif; other site 251221002967 Domain of unknown function (DUF4325); Region: DUF4325; pfam14213 251221002968 Domain of unknown function (DUF4351); Region: DUF4351; pfam14261 251221002969 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 251221002970 homodimer interface [polypeptide binding]; other site 251221002971 substrate-cofactor binding pocket; other site 251221002972 Aminotransferase class IV; Region: Aminotran_4; pfam01063 251221002973 catalytic residue [active] 251221002974 N-methylhydantoinase B/acetone carboxylase, alpha subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuB; COG0146 251221002975 Predicted ATPase involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: ArsA; COG0003 251221002976 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 251221002977 P loop; other site 251221002978 Nucleotide binding site [chemical binding]; other site 251221002979 DTAP/Switch II; other site 251221002980 Switch I; other site 251221002981 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 251221002982 Helix-turn-helix domains; Region: HTH; cl00088 251221002983 RNA polymerase factor sigma-32; Reviewed; Region: rpoH2; PRK07500 251221002984 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 251221002985 DNA binding residues [nucleotide binding] 251221002986 peptide chain release factor 2; Validated; Region: prfB; PRK00578 251221002987 RF-1 domain; Region: RF-1; cl02875 251221002988 RF-1 domain; Region: RF-1; cl02875 251221002989 Tetrapyrrole (Corrin/Porphyrin) Methylases; Region: TP_methylase; cl00304 251221002990 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 251221002991 active site 251221002992 Uroporphyrinogen-III synthase HemD; Region: HEM4; pfam02602 251221002993 The Delta9 Fatty Acid Desaturase (Delta9-FADS)-like CD includes the delta-9 and delta-11 acyl CoA desaturases found in various eukaryotes including vertebrates, insects, higher plants, and fungi. The delta-9 acyl-lipid desaturases are found in a wide...; Region: Delta9-FADS-like; cd03505 251221002994 Fatty acid desaturase; Region: FA_desaturase; pfam00487 251221002995 Di-iron ligands [ion binding]; other site 251221002996 Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cl00454 251221002997 Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cl00454 251221002998 PAS domain S-box; Region: sensory_box; TIGR00229 251221002999 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 251221003000 putative active site [active] 251221003001 heme pocket [chemical binding]; other site 251221003002 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 251221003003 PAS fold; Region: PAS_3; pfam08447 251221003004 putative active site [active] 251221003005 heme pocket [chemical binding]; other site 251221003006 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 251221003007 GAF domain; Region: GAF; cl00853 251221003008 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 251221003009 dimer interface [polypeptide binding]; other site 251221003010 phosphorylation site [posttranslational modification] 251221003011 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 251221003012 ATP binding site [chemical binding]; other site 251221003013 Mg2+ binding site [ion binding]; other site 251221003014 G-X-G motif; other site 251221003015 Protein of unknown function (DUF3252); Region: DUF3252; pfam11623 251221003016 Prokaryotic diacylglycerol kinase; Region: DAGK_prokar; cl00526 251221003017 Uncharacterized protein family UPF0054; Region: UPF0054; cl00402 251221003018 phycobillisome linker protein; Region: apcE; CHL00091 251221003019 Phycobilisome protein; Region: Phycobilisome; cl08227 251221003020 Phycobilisome Linker polypeptide; Region: PBS_linker_poly; pfam00427 251221003021 Phycobilisome Linker polypeptide; Region: PBS_linker_poly; pfam00427 251221003022 Phycobilisome Linker polypeptide; Region: PBS_linker_poly; pfam00427 251221003023 Phycobilisome Linker polypeptide; Region: PBS_linker_poly; pfam00427 251221003024 Phycobilisome protein; Region: Phycobilisome; cl08227 251221003025 Phycobilisome protein; Region: Phycobilisome; cl08227 251221003026 CpcD/allophycocyanin linker domain; Region: CpcD; cl03191 251221003027 Antibiotic biosynthesis monooxygenase; Region: ABM; cl10022 251221003028 riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326 251221003029 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 251221003030 catalytic motif [active] 251221003031 Zn binding site [ion binding]; other site 251221003032 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cl00161 251221003033 AIR carboxylase; Region: AIRC; cl00310 251221003034 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 251221003035 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087 251221003036 Phycobilisome protein; Region: Phycobilisome; cl08227 251221003037 FOG: HEAT repeat [Energy production and conversion]; Region: COG1413 251221003038 HEAT repeat; Region: HEAT; pfam02985 251221003039 FOG: HEAT repeat [Energy production and conversion]; Region: COG1413 251221003040 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 251221003041 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 251221003042 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 251221003043 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 251221003044 CpeS-like protein; Region: CpeS; pfam09367 251221003045 Ferredoxin-dependent bilin reductase; Region: Fe_bilin_red; cl07930 251221003046 Ferredoxin-dependent bilin reductase; Region: Fe_bilin_red; cl07930 251221003047 Phycobilisome Linker polypeptide; Region: PBS_linker_poly; pfam00427 251221003048 Phycobilisome Linker polypeptide; Region: PBS_linker_poly; pfam00427 251221003049 Phycobilisome Linker polypeptide; Region: PBS_linker_poly; pfam00427 251221003050 Phycobilisome Linker polypeptide; Region: PBS_linker_poly; pfam00427 251221003051 CpcD/allophycocyanin linker domain; Region: CpcD; cl03191 251221003052 Phycobilisome Linker polypeptide; Region: PBS_linker_poly; pfam00427 251221003053 CpcD/allophycocyanin linker domain; Region: CpcD; cl03191 251221003054 Phycobilisome Linker polypeptide; Region: PBS_linker_poly; pfam00427 251221003055 CpcD/allophycocyanin linker domain; Region: CpcD; cl03191 251221003056 CpcD/allophycocyanin linker domain; Region: CpcD; cl03191 251221003057 CpcD/allophycocyanin linker domain; Region: CpcD; cl03191 251221003058 FOG: HEAT repeat [Energy production and conversion]; Region: COG1413 251221003059 PBS lyase HEAT-like repeat; Region: HEAT_PBS; cl15388 251221003060 PBS lyase HEAT-like repeat; Region: HEAT_PBS; cl15388 251221003061 FOG: HEAT repeat [Energy production and conversion]; Region: COG1413 251221003062 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859 251221003063 Acidobacterial duplicated orphan permease; Region: ADOP; TIGR03434 251221003064 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 251221003065 FtsX-like permease family; Region: FtsX; pfam02687 251221003066 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 251221003067 FtsX-like permease family; Region: FtsX; pfam02687 251221003068 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 251221003069 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 251221003070 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 251221003071 Walker A/P-loop; other site 251221003072 ATP binding site [chemical binding]; other site 251221003073 Q-loop/lid; other site 251221003074 ABC transporter signature motif; other site 251221003075 Walker B; other site 251221003076 D-loop; other site 251221003077 H-loop/switch region; other site 251221003078 Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123 251221003079 Histone deacetylase domain; Region: Hist_deacetyl; cl02986 251221003080 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl00284 251221003081 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl00284 251221003082 Peptidase domain in the S53 family; Region: Peptidases_S53_like; cd05562 251221003083 putative active site [active] 251221003084 putative catalytic triad [active] 251221003085 Peptidase domain in the S53 family; Region: Peptidases_S53_like; cd05562 251221003086 Y-family of DNA polymerases; Region: PolY; cl12025 251221003087 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 251221003088 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 251221003089 generic binding surface II; other site 251221003090 ssDNA binding site; other site 251221003091 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 251221003092 ATP binding site [chemical binding]; other site 251221003093 putative Mg++ binding site [ion binding]; other site 251221003094 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 251221003095 nucleotide binding region [chemical binding]; other site 251221003096 ATP-binding site [chemical binding]; other site 251221003097 DNA mismatch repair protein MutL; Region: mutl; TIGR00585 251221003098 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 251221003099 ATP binding site [chemical binding]; other site 251221003100 Mg2+ binding site [ion binding]; other site 251221003101 G-X-G motif; other site 251221003102 MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is...; Region: MutL_Trans; cd00782 251221003103 ATP binding site [chemical binding]; other site 251221003104 MutL C terminal dimerisation domain; Region: MutL_C; cl07336 251221003105 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 251221003106 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 251221003107 Protein of unknown function (DUF1470); Region: DUF1470; pfam07336 251221003108 CGNR zinc finger; Region: zf-CGNR; pfam11706 251221003109 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2258 251221003110 MOSC domain; Region: MOSC; pfam03473 251221003111 3-alpha domain; Region: 3-alpha; pfam03475 251221003112 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 251221003113 putative active site [active] 251221003114 elongation factor P; Validated; Region: PRK00529 251221003115 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 251221003116 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 251221003117 RNA binding site [nucleotide binding]; other site 251221003118 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 251221003119 RNA binding site [nucleotide binding]; other site 251221003120 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302 251221003121 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 251221003122 carboxyltransferase (CT) interaction site; other site 251221003123 biotinylation site [posttranslational modification]; other site 251221003124 folylpolyglutamate synthase/dihydrofolate synthase; Region: folC; TIGR01499 251221003125 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 251221003126 The N-terminal ATPase domain of the maltose transporter, MalK. ATP binding cassette (ABC) proteins function from bacteria to human, mediating the translocation of substances into and out of cells or organelles. ABC transporters contain two...; Region: ABC_MalK_N; cd03301 251221003127 Walker A/P-loop; other site 251221003128 ATP binding site [chemical binding]; other site 251221003129 Q-loop/lid; other site 251221003130 ABC transporter signature motif; other site 251221003131 Walker B; other site 251221003132 D-loop; other site 251221003133 H-loop/switch region; other site 251221003134 TOBE domain; Region: TOBE_2; cl01440 251221003135 B12 binding domain_like associated with radical SAM domain. This domain shows similarity with B12 (adenosylcobamide) binding domains found in several enzymes, such as glutamate mutase, methionine synthase and methylmalonyl-CoA mutase, but it lacks the...; Region: radical_SAM_B12_BD; cd02068 251221003136 Elongator protein 3, MiaB family, Radical SAM; Region: Elp3; smart00729 251221003137 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 251221003138 FeS/SAM binding site; other site 251221003139 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 251221003140 putative active site [active] 251221003141 Uncharacterised BCR, COG1649; Region: DUF187; cl15398 251221003142 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 251221003143 S-adenosylmethionine binding site [chemical binding]; other site 251221003144 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 251221003145 TfuA-like protein; Region: TfuA; pfam07812 251221003146 putative methanogenesis marker protein 1; Region: methan_mark_1; TIGR03266 251221003147 YcaO-like family; Region: YcaO; cl09146 251221003148 ABC-type transport system involved in cytochrome bd biosynthesis, ATPase and permease components [Energy production and conversion / Posttranslational modification, protein turnover, chaperones]; Region: CydD; COG4988 251221003149 MsbA is an essential ABC transporter, closely related to eukaryotic MDR proteins. ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars, ions, peptides, and more complex organic...; Region: ABCC_MsbA; cd03251 251221003150 Walker A/P-loop; other site 251221003151 ATP binding site [chemical binding]; other site 251221003152 Q-loop/lid; other site 251221003153 ABC transporter signature motif; other site 251221003154 Walker B; other site 251221003155 D-loop; other site 251221003156 H-loop/switch region; other site 251221003157 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 251221003158 MsbA is an essential ABC transporter, closely related to eukaryotic MDR proteins. ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars, ions, peptides, and more complex organic...; Region: ABCC_MsbA; cd03251 251221003159 Walker A/P-loop; other site 251221003160 ATP binding site [chemical binding]; other site 251221003161 Q-loop/lid; other site 251221003162 ABC transporter signature motif; other site 251221003163 Walker B; other site 251221003164 D-loop; other site 251221003165 H-loop/switch region; other site 251221003166 ABC-2 type transporter; Region: ABC2_membrane; cl11417 251221003167 Domain of unknown function (DUF3526); Region: DUF3526; pfam12040 251221003168 ABC-2 type transporter; Region: ABC2_membrane; cl11417 251221003169 Domain of unknown function (DUF3526); Region: DUF3526; pfam12040 251221003170 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl00284 251221003171 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl00284 251221003172 glycogen branching enzyme; Provisional; Region: PRK05402 251221003173 Early set domain associated with the catalytic domain of sugar utilizing enzymes at either the N or C terminus; Region: E_set; cl09101 251221003174 N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855 251221003175 Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322 251221003176 active site 251221003177 catalytic site [active] 251221003178 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; cl02706 251221003179 N-acyl-D-aspartate/D-glutamate deacylase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3653 251221003180 D-aminoacylases (N-acyl-D-Amino acid amidohydrolases) catalyze the hydrolysis of N-acyl-D-amino acids to produce the corresponding D-amino acids, which are used as intermediates in the synthesis of pesticides, bioactive peptides, and antibiotics; Region: D-aminoacylase; cd01297 251221003181 active site 251221003182 putative substrate binding pocket [chemical binding]; other site 251221003183 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 251221003184 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 251221003185 C-terminal peptidase (prc); Region: prc; TIGR00225 251221003186 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 251221003187 protein binding site [polypeptide binding]; other site 251221003188 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 251221003189 Catalytic dyad [active] 251221003190 putative magnesium chelatase accessory protein; Region: bchO_mg_che_rel; TIGR03056 251221003191 Phosphoribosyl transferase domain; Region: Pribosyltran; cl00309 251221003192 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl12011 251221003193 Protein of unknown function (DUF2808); Region: DUF2808; pfam10989 251221003194 tellurium resistance terB-like protein; Region: terB_like; cd07177 251221003195 metal binding site [ion binding]; metal-binding site 251221003196 PhoD-like phosphatase; Region: PhoD; pfam09423 251221003197 Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389 251221003198 putative active site [active] 251221003199 putative metal binding site [ion binding]; other site 251221003200 Domain of unknown function (DUF4272); Region: DUF4272; pfam14094 251221003201 IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639 251221003202 active site 251221003203 dimerization interface [polypeptide binding]; other site 251221003204 histidinol-phosphate aminotransferase; Region: hisC; TIGR01141 251221003205 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 251221003206 pyridoxal 5'-phosphate binding site [chemical binding]; other site 251221003207 homodimer interface [polypeptide binding]; other site 251221003208 catalytic residue [active] 251221003209 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 251221003210 histidinol dehydrogenase; Region: hisD; TIGR00069 251221003211 NAD binding site [chemical binding]; other site 251221003212 dimerization interface [polypeptide binding]; other site 251221003213 product binding site; other site 251221003214 substrate binding site [chemical binding]; other site 251221003215 zinc binding site [ion binding]; other site 251221003216 catalytic residues [active] 251221003217 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 251221003218 putative active site [active] 251221003219 catalytic triad [active] 251221003220 Alpha-amylase/alpha-mannosidase [Carbohydrate transport and metabolism]; Region: COG1449 251221003221 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514 251221003222 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 251221003223 putative active site [active] 251221003224 Cobalamin binding protein BtuF. These proteins have been shown to function as initial receptors in ABC transport of vitamin B12 (cobalamin) in eubacterial and some archaeal species. They belong to the TroA superfamily of helical backbone metal receptor...; Region: BtuF; cd01144 251221003225 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 251221003226 cobalamin binding residues [chemical binding]; other site 251221003227 putative BtuC binding residues; other site 251221003228 dimer interface [polypeptide binding]; other site 251221003229 TIGR03663 family protein; Region: TIGR03663 251221003230 RES domain; Region: RES; cl02411 251221003231 RNA polymerase sigma factor, cyanobacterial RpoD-like family; Region: Sig70-cyanoRpoD; TIGR02997 251221003232 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 251221003233 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149 251221003234 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 251221003235 protein binding site [polypeptide binding]; other site 251221003236 RNA binding domain of NusB (N protein-Utilization Substance B) and Sun (also known as RrmB or Fmu) proteins. This family includes two orthologous groups exemplified by the transcription termination factor NusB and the N-terminal domain of the...; Region: NusB_Sun; cl00223 251221003237 Predicted SPOUT methyltransferase; Region: SPOUT_MTase; cl00679 251221003238 birA, biotin-[acetyl-CoA-carboxylase] ligase region; Region: birA_ligase; TIGR00121 251221003239 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 251221003240 Tudor domains are found in many eukaryotic organisms and have been implicated in protein-protein interactions in which methylated protein substrates bind to these domains. For example, the Tudor domain of Survival of Motor Neuron (SMN) binds to...; Region: TUDOR; cl02573 251221003241 Peptidase family M48; Region: Peptidase_M48; cl12018 251221003242 LysR transcriptional regulator; Provisional; Region: rbcR; CHL00180 251221003243 Helix-turn-helix domains; Region: HTH; cl00088 251221003244 C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420 251221003245 putative dimerization interface [polypeptide binding]; other site 251221003246 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 251221003247 glutathione-regulated potassium-efflux system protein KefC; Provisional; Region: PRK03562 251221003248 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 251221003249 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 251221003250 Putative glucoamylase type of glycohydrolase; Region: Glucoamylase; pfam03080 251221003251 TOMM system kinase/cyclase multidomain protein; Region: TOMM_kin_cyc; TIGR03903 251221003252 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: APH_ChoK_like; cl15691 251221003253 Protein of unknown function (DUF3365); Region: DUF3365; pfam11845 251221003254 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 251221003255 dimerization interface [polypeptide binding]; other site 251221003256 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 251221003257 phosphopeptide binding site; other site 251221003258 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011 251221003259 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 251221003260 motif II; other site 251221003261 UGMP family protein; Validated; Region: PRK09604 251221003262 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl14000 251221003263 Carbamoyltransferase; Region: CmcH_NodU; pfam02543 251221003264 Protein of unknown function (DUF422); Region: DUF422; cl00991 251221003265 hopene-associated glycosyltransferase HpnB; Region: HpnB; TIGR03469 251221003266 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 251221003267 active site 251221003268 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cl01898 251221003269 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 251221003270 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 251221003271 tellurium resistance terB-like protein; Region: terB_like; cd07177 251221003272 metal binding site [ion binding]; metal-binding site 251221003273 Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; cl00398 251221003274 Putative modulator of DNA gyrase; Region: PmbA_TldD; pfam01523 251221003275 Protein of unknown function (DUF3616); Region: DUF3616; pfam12275 251221003276 Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase; Region: Glucosaminidase; cl00743 251221003277 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 251221003278 active site 251221003279 metal binding site [ion binding]; metal-binding site 251221003280 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 251221003281 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 251221003282 ATP binding site [chemical binding]; other site 251221003283 putative Mg++ binding site [ion binding]; other site 251221003284 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 251221003285 nucleotide binding region [chemical binding]; other site 251221003286 ATP-binding site [chemical binding]; other site 251221003287 Predicted nuclease of restriction endonuclease-like fold [General function prediction only]; Region: COG3372 251221003288 Protein of unknown function (DUF790); Region: DUF790; pfam05626 251221003289 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 251221003290 putative active site [active] 251221003291 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 251221003292 PA_GCPII_like: Protease-associated domain containing protein, glutamate carboxypeptidase II (GCPII)-like. This group contains various PA domain-containing proteins similar to GCPII including, GCPIII (NAALADase2) and NAALADase L. These proteins belong to...; Region: PA_GCPII_like; cd02121 251221003293 apical/protease domain interface [polypeptide binding]; other site 251221003294 substrate binding [chemical binding]; other site 251221003295 dimer interface [polypeptide binding]; other site 251221003296 M28 Zn-peptidase prostate-specific membrane antigen; Region: M28_PSMA_like; cd08022 251221003297 dimer interface [polypeptide binding]; other site 251221003298 active site 251221003299 metal binding site [ion binding]; metal-binding site 251221003300 Transferrin receptor-like dimerisation domain; Region: TFR_dimer; pfam04253 251221003301 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 251221003302 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 251221003303 FeS assembly SUF system regulator, gammaproteobacterial; Region: suf_reg_Xantho; TIGR02944 251221003304 Helix-turn-helix domains; Region: HTH; cl00088 251221003305 Uncharacterized protein family (UPF0051); Region: UPF0051; cl03223 251221003306 putative ABC transporter; Region: ycf24; CHL00085 251221003307 FeS assembly ATPase SufC; Region: sufC; TIGR01978 251221003308 ABC-type transport system involved in Fe-S cluster assembly, ATPase component. Biosynthesis of iron-sulfur clusters (Fe-S) depends on multiprotein systems. The SUF system of E. coli and Erwinia chrysanthemi is important for Fe-S biogenesis under...; Region: ABC_FeS_Assembly; cd03217 251221003309 Walker A/P-loop; other site 251221003310 ATP binding site [chemical binding]; other site 251221003311 Q-loop/lid; other site 251221003312 ABC transporter signature motif; other site 251221003313 Walker B; other site 251221003314 D-loop; other site 251221003315 H-loop/switch region; other site 251221003316 Cysteine desulfurase activator SufB [Posttranslational modification, protein turnover, chaperones]; Region: SufB; COG0719 251221003317 Uncharacterized protein family (UPF0051); Region: UPF0051; cl03223 251221003318 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 251221003319 Aminotransferase class-V; Region: Aminotran_5; pfam00266 251221003320 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 251221003321 catalytic residue [active] 251221003322 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 251221003323 trimerization site [polypeptide binding]; other site 251221003324 active site 251221003325 Domain of unknown function DUF59; Region: DUF59; cl00941 251221003326 Bacterial transcriptional activator domain; Region: BTAD; pfam03704 251221003327 Tetratricopeptide repeat; Region: TPR_12; pfam13424 251221003328 Tetrapyrrole (Corrin/Porphyrin) Methylases; Region: TP_methylase; cl00304 251221003329 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 251221003330 putative active site [active] 251221003331 PseudoU_synth: Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi). Pseudouridine synthases contains the RsuA/RluD, TruA, TruB and TruD families. This group consists of...; Region: PseudoU_synth; cl00130 251221003332 pseudouridine synthase; Region: TIGR00093 251221003333 active site 251221003334 TonB-dependent vitamin B12 receptor; Region: TonB-B12; TIGR01779 251221003335 TonB-dependent heme/hemoglobin receptor family protein; Region: TonB-hemin; TIGR01785 251221003336 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl00284 251221003337 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 251221003338 putative active site [active] 251221003339 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 251221003340 binding surface 251221003341 TPR motif; other site 251221003342 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 251221003343 binding surface 251221003344 TPR motif; other site 251221003345 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 251221003346 binding surface 251221003347 TPR motif; other site 251221003348 Sulfotransferase domain; Region: Sulfotransfer_1; pfam00685 251221003349 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 251221003350 N-terminal plug; other site 251221003351 ligand-binding site [chemical binding]; other site 251221003352 TonB-dependent vitamin B12 receptor; Region: TonB-B12; TIGR01779 251221003353 TonB-dependent hemoglobin/transferrin/lactoferrin receptor family protein; Region: TonB-hemlactrns; TIGR01786 251221003354 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 251221003355 Biopolymer transport protein ExbD/TolR; Region: ExbD; cl00537 251221003356 Gram-negative bacterial tonB protein; Region: TonB; cl10048 251221003357 arsenite-activated ATPase ArsA; Region: arsA; TIGR00345 251221003358 RRM (RNA recognition motif), also known as RBD (RNA binding domain) or RNP (ribonucleoprotein domain), is a highly abundant domain in eukaryotes found in proteins involved in post-transcriptional gene expression processes including mRNA and rRNA...; Region: RRM; cd00590 251221003359 RNA/DNA binding site [nucleotide binding]; other site 251221003360 RRM dimerization site [polypeptide binding]; other site 251221003361 adenylate kinase; Reviewed; Region: adk; PRK00279 251221003362 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 251221003363 AMP-binding site [chemical binding]; other site 251221003364 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 251221003365 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 251221003366 SecY translocase; Region: SecY; pfam00344 251221003367 Fe-S oxidoreductase [Energy production and conversion]; Region: COG1032 251221003368 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 251221003369 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 251221003370 FeS/SAM binding site; other site 251221003371 Protein of unknown function (DUF3531); Region: DUF3531; pfam12049 251221003372 Cytidylyltransferase family; Region: CTP_transf_1; cl00347 251221003373 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 251221003374 putative active site pocket [active] 251221003375 dimerization interface [polypeptide binding]; other site 251221003376 putative catalytic residue [active] 251221003377 Domain of unknown function (DUF1818); Region: DUF1818; pfam08848 251221003378 Thylakoid formation protein; Region: ThylakoidFormat; cl12138 251221003379 phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647 251221003380 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 251221003381 active site 251221003382 cosubstrate binding site; other site 251221003383 substrate binding site [chemical binding]; other site 251221003384 catalytic site [active] 251221003385 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 251221003386 dimer interface [polypeptide binding]; other site 251221003387 conserved gate region; other site 251221003388 putative PBP binding loops; other site 251221003389 ABC-ATPase subunit interface; other site 251221003390 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 251221003391 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 251221003392 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 251221003393 Walker A/P-loop; other site 251221003394 ATP binding site [chemical binding]; other site 251221003395 Q-loop/lid; other site 251221003396 ABC transporter signature motif; other site 251221003397 Walker B; other site 251221003398 D-loop; other site 251221003399 H-loop/switch region; other site 251221003400 TOBE domain; Region: TOBE_2; cl01440 251221003401 putative protein serine/threonine phosphatase; Provisional; Region: PRK14559 251221003402 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 251221003403 Protein phosphatase 2C; Region: PP2C; pfam00481 251221003404 active site 251221003405 Double zinc ribbon; Region: DZR; pfam12773 251221003406 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 251221003407 phosphopeptide binding site; other site 251221003408 Domain of unknown function DUF11; Region: DUF11; cl15273 251221003409 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 251221003410 structural tetrad; other site 251221003411 Domain of unknown function (DUF4159); Region: DUF4159; pfam13709 251221003412 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl09108 251221003413 Phage tail protein (Tail_P2_I); Region: Tail_P2_I; cl01817 251221003414 Baseplate J-like protein; Region: Baseplate_J; cl01294 251221003415 Gene 25-like lysozyme; Region: GPW_gp25; cl01403 251221003416 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 251221003417 putative active site [active] 251221003418 Coenzyme Q (ubiquinone) biosynthesis protein Coq4; Region: Coq4; cl02093 251221003419 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 251221003420 Helix-turn-helix domains; Region: HTH; cl00088 251221003421 Acidobacterial duplicated orphan permease; Region: ADOP; TIGR03434 251221003422 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 251221003423 FtsX-like permease family; Region: FtsX; pfam02687 251221003424 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 251221003425 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 251221003426 Helix-turn-helix domains; Region: HTH; cl00088 251221003427 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 251221003428 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 251221003429 NAD(P) binding site [chemical binding]; other site 251221003430 active site 251221003431 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 251221003432 oxidoreductase; Provisional; Region: PRK06196 251221003433 retinol dehydrogenase (retinol-DH), Light dependent Protochlorophyllide (Pchlide) OxidoReductase (LPOR) and related proteins, classical (c) SDRs; Region: retinol-DH_like_SDR_c_like; cd05327 251221003434 putative NAD(P) binding site [chemical binding]; other site 251221003435 active site 251221003436 HEPN domain; Region: HEPN; cl00824 251221003437 ABC exporter ATP-binding subunit, DevA family; Region: heterocyst_DevA; TIGR02982 251221003438 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 251221003439 Walker A/P-loop; other site 251221003440 ATP binding site [chemical binding]; other site 251221003441 Q-loop/lid; other site 251221003442 ABC transporter signature motif; other site 251221003443 Walker B; other site 251221003444 D-loop; other site 251221003445 H-loop/switch region; other site 251221003446 DevC protein; Region: devC; TIGR01185 251221003447 FtsX-like permease family; Region: FtsX; pfam02687 251221003448 ABC exporter membrane fusion protein, DevB family; Region: heterocyst_DevB; TIGR02971 251221003449 Helix-turn-helix domains; Region: HTH; cl00088 251221003450 Virulence activator alpha C-term; Region: Vir_act_alpha_C; pfam10400 251221003451 This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809 251221003452 N-terminal Early set domain, a glycogen binding domain, associated with the catalytic domain of AMP-activated protein kinase beta subunit; Region: E_set_AMPKbeta_like_N; cd02859 251221003453 malto-oligosyltrehalose trehalohydrolase; Region: trehalose_TreZ; TIGR02402 251221003454 glycogen binding site [chemical binding]; other site 251221003455 Alpha amylase catalytic domain found in an uncharacterized protein family; Region: AmyAc_4; cd11350 251221003456 active site 251221003457 catalytic site [active] 251221003458 DNA polymerase III subunit delta'; Validated; Region: PRK07399 251221003459 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 251221003460 proline iminopeptidase, Neisseria-type subfamily; Region: pro_imino_pep_1; TIGR01249 251221003461 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 251221003462 Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; Region: SRPBCC_CalC_Aha1-like_9; cd07826 251221003463 putative hydrophobic ligand binding site [chemical binding]; other site 251221003464 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 251221003465 dimerization interface [polypeptide binding]; other site 251221003466 putative DNA binding site [nucleotide binding]; other site 251221003467 putative Zn2+ binding site [ion binding]; other site 251221003468 Helix-turn-helix domains; Region: HTH; cl00088 251221003469 atypical (a) SDRs, subgroup 7; Region: SDR_a7; cd05262 251221003470 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 251221003471 putative NAD(P) binding site [chemical binding]; other site 251221003472 PsbP; Region: PsbP; cl03356 251221003473 excinuclease ABC, C subunit; Region: uvrC; TIGR00194 251221003474 light-harvesting-like protein 3; Provisional; Region: PLN00014 251221003475 Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; cl00398 251221003476 Putative modulator of DNA gyrase; Region: PmbA_TldD; pfam01523 251221003477 Protein of unknown function (DUF2808); Region: DUF2808; pfam10989 251221003478 Class II Glycyl-tRNA synthetase (GlyRS) alpha subunit core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes and in arabidopsis. It is responsible for the...; Region: GlyRS_alpha_core; cd00733 251221003479 dimer interface [polypeptide binding]; other site 251221003480 motif 1; other site 251221003481 active site 251221003482 motif 2; other site 251221003483 motif 3; other site 251221003484 Uncharacterized conserved protein [Function unknown]; Region: COG1432 251221003485 LabA_like proteins; Region: LabA; cd10911 251221003486 putative metal binding site [ion binding]; other site 251221003487 ribonuclease R; Region: RNase_R; TIGR02063 251221003488 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 251221003489 RNB domain; Region: RNB; pfam00773 251221003490 S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase play an important...; Region: S1_RNase_R; cd04471 251221003491 RNA binding site [nucleotide binding]; other site 251221003492 Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199 251221003493 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 251221003494 Outer membrane cobalamin receptor protein [Coenzyme metabolism]; Region: BtuB; COG4206 251221003495 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 251221003496 N-terminal plug; other site 251221003497 ligand-binding site [chemical binding]; other site 251221003498 FOG: CBS domain [General function prediction only]; Region: COG0517 251221003499 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with an upstream DHH domain which performs a phosphoesterase function and a downstream polyA polymerase domain. CBS is a small domain originally...; Region: CBS_pair_DHH_polyA_Pol_assoc; cd04595 251221003500 tRNA nucleotidyltransferase/poly(A) polymerase [Translation, ribosomal structure and biogenesis]; Region: PcnB; COG0617 251221003501 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 251221003502 active site 251221003503 NTP binding site [chemical binding]; other site 251221003504 metal binding triad [ion binding]; metal-binding site 251221003505 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 251221003506 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 251221003507 Cation efflux family; Region: Cation_efflux; cl00316 251221003508 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 251221003509 Ligand Binding Site [chemical binding]; other site 251221003510 Glycerol dehydrogenases-like; Region: GlyDH-like1; cd08172 251221003511 Iron-containing alcohol dehydrogenase; Region: Fe-ADH; pfam00465 251221003512 putative active site [active] 251221003513 metal binding site [ion binding]; metal-binding site 251221003514 aspartate ammonia-lyase; Region: aspA; TIGR00839 251221003515 Lyase class I_like superfamily: contains the lyase class I family, histidine ammonia-lyase and phenylalanine ammonia-lyase, which catalyze similar beta-elimination reactions; Region: Lyase_I_like; cl00013 251221003516 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 251221003517 active site 251221003518 The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467 251221003519 atypical (a) SDRs, subgroup 5; Region: SDR_a5; cd05243 251221003520 Ycf39; Provisional; Region: ycf39; CHL00194 251221003521 NAD(P) binding site [chemical binding]; other site 251221003522 putative active site [active] 251221003523 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 251221003524 DNA binding site [nucleotide binding] 251221003525 active site 251221003526 NCAIR mutase (PurE)-related proteins [General function prediction only]; Region: COG1691 251221003527 AIR carboxylase; Region: AIRC; cl00310 251221003528 threonine synthase; Reviewed; Region: PRK06721 251221003529 Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants; Region: Thr-synth_1; cd01563 251221003530 homodimer interface [polypeptide binding]; other site 251221003531 pyridoxal 5'-phosphate binding site [chemical binding]; other site 251221003532 catalytic residue [active] 251221003533 Uncharacterized Fe-S protein [Energy production and conversion]; Region: COG1600 251221003534 Domain of unknown function (DUF1730); Region: DUF1730; pfam08331 251221003535 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 251221003536 trimer interface [polypeptide binding]; other site 251221003537 active site 251221003538 rod shape-determining protein MreB; Provisional; Region: PRK13927 251221003539 Cell division protein FtsA; Region: FtsA; cl11496 251221003540 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: APH_ChoK_like; cl15691 251221003541 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506 251221003542 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 251221003543 integral membrane protein MviN; Region: mviN; TIGR01695 251221003544 Predicted aminomethyltransferase related to GcvT [General function prediction only]; Region: COG0354 251221003545 folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317 251221003546 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 251221003547 chromosomal replication initiation protein; Reviewed; Region: dnaA; PRK00149 251221003548 hypothetical protein; Validated; Region: PRK06672 251221003549 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 251221003550 Walker A motif; other site 251221003551 ATP binding site [chemical binding]; other site 251221003552 Walker B motif; other site 251221003553 arginine finger; other site 251221003554 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 251221003555 DnaA box-binding interface [nucleotide binding]; other site 251221003556 Ribonuclease P; Region: Ribonuclease_P; cl00457 251221003557 Bacterial membrane flanked domain; Region: DUF304; cl01348 251221003558 Bacterial domain of unknown function (DUF403); Region: DUF403; cl00980 251221003559 Helix-turn-helix domains; Region: HTH; cl00088 251221003560 Acidobacterial duplicated orphan permease; Region: ADOP; TIGR03434 251221003561 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 251221003562 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 251221003563 FtsX-like permease family; Region: FtsX; pfam02687 251221003564 antiporter inner membrane protein; Provisional; Region: PRK11670 251221003565 Domain of unknown function DUF59; Region: DUF59; cl00941 251221003566 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 251221003567 Domain of unknown function DUF29; Region: DUF29; pfam01724 251221003568 PUCC protein; Region: PUCC; pfam03209 251221003569 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 251221003570 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 251221003571 S-adenosylmethionine binding site [chemical binding]; other site 251221003572 Protein of unknown function (DUF2869); Region: DUF2869; pfam11068 251221003573 Ferredoxin [Energy production and conversion]; Region: COG1146 251221003574 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 251221003575 Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511 251221003576 Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1), 6-pyrovoyl...; Region: TFold; cl00263 251221003577 active site 251221003578 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 251221003579 N-terminal plug; other site 251221003580 ligand-binding site [chemical binding]; other site 251221003581 Predicted ATPase [General function prediction only]; Region: COG4637 251221003582 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 251221003583 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 251221003584 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 251221003585 Major Facilitator Superfamily; Region: MFS_1; pfam07690 251221003586 putative substrate translocation pore; other site 251221003587 Transglycosylase; Region: Transgly; cl07896 251221003588 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 251221003589 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 251221003590 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 251221003591 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 251221003592 PAS domain S-box; Region: sensory_box; TIGR00229 251221003593 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 251221003594 putative active site [active] 251221003595 heme pocket [chemical binding]; other site 251221003596 GAF domain; Region: GAF; cl00853 251221003597 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 251221003598 dimer interface [polypeptide binding]; other site 251221003599 phosphorylation site [posttranslational modification] 251221003600 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 251221003601 ATP binding site [chemical binding]; other site 251221003602 Mg2+ binding site [ion binding]; other site 251221003603 G-X-G motif; other site 251221003604 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 251221003605 SmpB-tmRNA interface; other site 251221003606 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 251221003607 Protein of unknown function (DUF4079); Region: DUF4079; pfam13301 251221003608 Bacterial Ig-like domain; Region: Big_5; cl01012 251221003609 cyclophilin_TLP40_like: cyclophilin-type peptidylprolyl cis- trans isomerases (cyclophilins) similar ot the Spinach thylakoid lumen protein TLP40. Compared to the archetypal cyclophilin Human cyclophilin A, these proteins have similar peptidylprolyl...; Region: cyclophilin_TLP40_like; cd01924 251221003610 active site 251221003611 polyphosphate kinase; Provisional; Region: PRK05443 251221003612 Catalytic C-terminal domain, first repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C1_like; cd09165 251221003613 putative domain interface [polypeptide binding]; other site 251221003614 putative active site [active] 251221003615 catalytic site [active] 251221003616 Catalytic C-terminal domain, second repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C2_like; cd09168 251221003617 putative domain interface [polypeptide binding]; other site 251221003618 putative active site [active] 251221003619 catalytic site [active] 251221003620 SpoIVFB Site-2 protease (S2P), a zinc metalloprotease (MEROPS family M50B), regulates intramembrane proteolysis (RIP), and is involved in the pro-sigmaK pathway of bacterial spore formation. In this subgroup, SpoIVFB (sporulation protein, stage IV cell...; Region: S2P-M50_SpoIVFB_CBS; cd06164 251221003621 active site 251221003622 putative substrate binding region [chemical binding]; other site 251221003623 FOG: CBS domain [General function prediction only]; Region: COG0517 251221003624 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with the metalloprotease peptidase M50. CBS is a small domain originally identified in cystathionine beta-synthase and subsequently found in a wide...; Region: CBS_pair_M50_like; cd04801 251221003625 TIGR03032 family protein; Region: TIGR03032 251221003626 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 251221003627 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 251221003628 RimM N-terminal domain; Region: RimM; pfam01782 251221003629 Photosynthetic reaction center (RC) complex, subunit H; RC is an integral membrane protein-pigment complex which catalyzes light-induced reduction of ubiquinone to ubiquinol, generating a transmembrane electrochemical gradient of protons used to produce...; Region: PRCH; cl09959 251221003630 ribonuclease, Rne/Rng family; Region: RNaseEG; TIGR00757 251221003631 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 251221003632 homodimer interface [polypeptide binding]; other site 251221003633 oligonucleotide binding site [chemical binding]; other site 251221003634 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 251221003635 RNA/DNA hybrid binding site [nucleotide binding]; other site 251221003636 active site 251221003637 glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750 251221003638 Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713 251221003639 active site 251221003640 dimer interface [polypeptide binding]; other site 251221003641 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 251221003642 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 251221003643 active site 251221003644 FMN binding site [chemical binding]; other site 251221003645 substrate binding site [chemical binding]; other site 251221003646 3Fe-4S cluster binding site [ion binding]; other site 251221003647 gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982 251221003648 domain interface; other site 251221003649 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 251221003650 Helix-Turn-Helix DNA binding domain of putative transcription regulators from the MerR superfamily; Region: HTH_MerR-like_sg4; cd04779 251221003651 Cd(II)/Pb(II)-responsive transcriptional regulator; Region: CadR-PbrR; TIGR02047 251221003652 DNA binding residues [nucleotide binding] 251221003653 putative dimer interface [polypeptide binding]; other site 251221003654 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 251221003655 dimer interface [polypeptide binding]; other site 251221003656 substrate binding site [chemical binding]; other site 251221003657 ATP binding site [chemical binding]; other site 251221003658 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 251221003659 S-adenosylmethionine binding site [chemical binding]; other site 251221003660 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 251221003661 putative active site [active] 251221003662 Protein of unknown function (DUF1517); Region: DUF1517; cl01807 251221003663 Protein-L-isoaspartate carboxylmethyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: Pcm; COG2518 251221003664 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 251221003665 S-adenosylmethionine binding site [chemical binding]; other site 251221003666 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 251221003667 S-adenosylmethionine binding site [chemical binding]; other site 251221003668 Protein-L-isoaspartate carboxylmethyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: Pcm; COG2518 251221003669 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 251221003670 S-adenosylmethionine binding site [chemical binding]; other site 251221003671 Bacterial Micro-Compartment (BMC)-like domain 1 repeat 1; Region: BMC_like_1_repeat1; cd07051 251221003672 putative hexamer interface [polypeptide binding]; other site 251221003673 putative hexagonal pore; other site 251221003674 Bacterial Micro-Compartment (BMC) domain; Region: BMC; cl01982 251221003675 Hexamer interface [polypeptide binding]; other site 251221003676 Hexagonal pore residue; other site 251221003677 GTP-binding protein TypA/BipA; Region: TypA_BipA; TIGR01394 251221003678 TypA (tyrosine phosphorylated protein A)/BipA subfamily. BipA is a protein belonging to the ribosome-binding family of GTPases and is widely distributed in bacteria and plants. BipA was originally described as a protein that is induced in Salmonella...; Region: TypA_BipA; cd01891 251221003679 G1 box; other site 251221003680 putative GEF interaction site [polypeptide binding]; other site 251221003681 GTP/Mg2+ binding site [chemical binding]; other site 251221003682 Switch I region; other site 251221003683 G2 box; other site 251221003684 G3 box; other site 251221003685 Switch II region; other site 251221003686 G4 box; other site 251221003687 G5 box; other site 251221003688 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 251221003689 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 251221003690 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 251221003691 catalytic loop [active] 251221003692 iron binding site [ion binding]; other site 251221003693 Cyanobacterial and plastid NDH-1 subunit M; Region: NdhM; pfam10664 251221003694 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 251221003695 putative active site [active] 251221003696 CTP synthetase; Validated; Region: pyrG; PRK05380 251221003697 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 251221003698 Catalytic site [active] 251221003699 active site 251221003700 UTP binding site [chemical binding]; other site 251221003701 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 251221003702 active site 251221003703 putative oxyanion hole; other site 251221003704 catalytic triad [active] 251221003705 C-terminal processing peptidase family S41; Region: Peptidase_S41; cd06567 251221003706 Active site serine [active] 251221003707 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 251221003708 This family is most closely related to the GT1 family of glycosyltransferases. wbaZ in Salmonella enterica has been shown to possess the mannosyl transferase activity. The members of this family are found in certain bacteria and Archaea; Region: GT1_wbaZ_like; cd03804 251221003709 putative ADP-binding pocket [chemical binding]; other site 251221003710 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 251221003711 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cl11426 251221003712 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_y; TIGR03182 251221003713 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 251221003714 tetramer interface [polypeptide binding]; other site 251221003715 TPP-binding site [chemical binding]; other site 251221003716 heterodimer interface [polypeptide binding]; other site 251221003717 phosphorylation loop region [posttranslational modification] 251221003718 pyruvate dehydrogenase E1 component beta subunit; Validated; Region: odpB; CHL00144 251221003719 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 251221003720 alpha subunit interface [polypeptide binding]; other site 251221003721 TPP binding site [chemical binding]; other site 251221003722 heterodimer interface [polypeptide binding]; other site 251221003723 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 251221003724 CpeS-like protein; Region: CpeS; pfam09367 251221003725 Response regulator receiver domain; Region: Response_reg; pfam00072 251221003726 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 251221003727 active site 251221003728 phosphorylation site [posttranslational modification] 251221003729 intermolecular recognition site; other site 251221003730 dimerization interface [polypeptide binding]; other site 251221003731 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 251221003732 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 251221003733 active site 251221003734 phosphorylation site [posttranslational modification] 251221003735 intermolecular recognition site; other site 251221003736 dimerization interface [polypeptide binding]; other site 251221003737 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 251221003738 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 251221003739 dimer interface [polypeptide binding]; other site 251221003740 phosphorylation site [posttranslational modification] 251221003741 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 251221003742 ATP binding site [chemical binding]; other site 251221003743 G-X-G motif; other site 251221003744 Response regulator receiver domain; Region: Response_reg; pfam00072 251221003745 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 251221003746 active site 251221003747 phosphorylation site [posttranslational modification] 251221003748 intermolecular recognition site; other site 251221003749 dimerization interface [polypeptide binding]; other site 251221003750 Alpha-glucosidase II (alpha-D-glucoside glucohydrolase) is a glycosyl hydrolase family 31 (GH31) enzyme, found in bacteria and plants, which has exo-alpha-1,4-glucosidase and oligo-1,6-glucosidase activities. Alpha-glucosidase II has been characterized...; Region: GH31_glucosidase_II_MalA; cd06604 251221003751 trimer interface [polypeptide binding]; other site 251221003752 active site 251221003753 homohexamer (dimer of homotrimer) interface [polypeptide binding]; other site 251221003754 catalytic site [active] 251221003755 Mechanosensitive ion channel; Region: MS_channel; pfam00924 251221003756 DEP domain, named after Dishevelled, Egl-10, and Pleckstrin, where this domain was first discovered. The function of this domain is still not clear, but it is believed to be important for the membrane association of the signaling proteins in which it is...; Region: DEP; cd04371 251221003757 DEP domain, named after Dishevelled, Egl-10, and Pleckstrin, where this domain was first discovered. The function of this domain is still not clear, but it is believed to be important for the membrane association of the signaling proteins in which it is...; Region: DEP; cd04371 251221003758 DEP domain, named after Dishevelled, Egl-10, and Pleckstrin, where this domain was first discovered. The function of this domain is still not clear, but it is believed to be important for the membrane association of the signaling proteins in which it is...; Region: DEP; cd04371 251221003759 CpeT/CpcT family (DUF1001); Region: CpeT; pfam06206 251221003760 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 251221003761 Helix-turn-helix domains; Region: HTH; cl00088 251221003762 Clp protease ATP binding subunit; Region: clpC; CHL00095 251221003763 Clp amino terminal domain; Region: Clp_N; pfam02861 251221003764 Clp amino terminal domain; Region: Clp_N; pfam02861 251221003765 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 251221003766 Walker A motif; other site 251221003767 ATP binding site [chemical binding]; other site 251221003768 Walker B motif; other site 251221003769 arginine finger; other site 251221003770 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 251221003771 Walker A motif; other site 251221003772 ATP binding site [chemical binding]; other site 251221003773 Walker B motif; other site 251221003774 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; cl11083 251221003775 Helix-turn-helix domains; Region: HTH; cl00088 251221003776 Protein of unknown function (DUF2384); Region: DUF2384; pfam09722 251221003777 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 251221003778 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 251221003779 Major Facilitator Superfamily; Region: MFS_1; pfam07690 251221003780 putative substrate translocation pore; other site 251221003781 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 251221003782 TPR motif; other site 251221003783 binding surface 251221003784 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 251221003785 binding surface 251221003786 TPR motif; other site 251221003787 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 251221003788 binding surface 251221003789 TPR motif; other site 251221003790 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 251221003791 Flavoprotein; Region: Flavoprotein; cl08021 251221003792 DNA / pantothenate metabolism flavoprotein; Region: DFP; cl04410 251221003793 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 251221003794 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 251221003795 Catalytic domain of Protein Kinases; Region: PKc; cd00180 251221003796 active site 251221003797 ATP binding site [chemical binding]; other site 251221003798 substrate binding site [chemical binding]; other site 251221003799 activation loop (A-loop); other site 251221003800 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 251221003801 binding surface 251221003802 TPR motif; other site 251221003803 Peptidase S8 family domain in Thermitase-like proteins; Region: Peptidases_S8_Thermitase_like; cd07484 251221003804 active site 251221003805 catalytic triad [active] 251221003806 Membrane protein of unknown function; Region: DUF360; cl00850 251221003807 ferredoxin-nitrite reductase; Reviewed; Region: nirA; PRK09566 251221003808 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 251221003809 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 251221003810 DNA-binding transcriptional regulator CynR; Provisional; Region: PRK11242 251221003811 Helix-turn-helix domains; Region: HTH; cl00088 251221003812 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 251221003813 dimerization interface [polypeptide binding]; other site 251221003814 hypothetical protein; Provisional; Region: PRK07394 251221003815 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 251221003816 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 251221003817 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 251221003818 putative active site [active] 251221003819 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 251221003820 putative active site [active] 251221003821 Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; cl00398 251221003822 Putative modulator of DNA gyrase; Region: PmbA_TldD; pfam01523 251221003823 Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; cl00398 251221003824 Putative modulator of DNA gyrase; Region: PmbA_TldD; pfam01523 251221003825 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 251221003826 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 251221003827 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl15260 251221003828 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 251221003829 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 251221003830 dimer interface [polypeptide binding]; other site 251221003831 conserved gate region; other site 251221003832 putative PBP binding loops; other site 251221003833 ABC-ATPase subunit interface; other site 251221003834 NrtD and SsuB are the ATP-binding subunits of the bacterial ABC-type nitrate and sulfonate transport systems, respectively. ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars; Region: ABC_NrtD_SsuB_transporters; cd03293 251221003835 nitrate transport ATP-binding subunits C and D; Region: ntrCD; TIGR01184 251221003836 Walker A/P-loop; other site 251221003837 ATP binding site [chemical binding]; other site 251221003838 Q-loop/lid; other site 251221003839 ABC transporter signature motif; other site 251221003840 Walker B; other site 251221003841 D-loop; other site 251221003842 H-loop/switch region; other site 251221003843 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 251221003844 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl15260 251221003845 NrtD and SsuB are the ATP-binding subunits of the bacterial ABC-type nitrate and sulfonate transport systems, respectively. ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars; Region: ABC_NrtD_SsuB_transporters; cd03293 251221003846 nitrate transport ATP-binding subunits C and D; Region: ntrCD; TIGR01184 251221003847 Walker A/P-loop; other site 251221003848 ATP binding site [chemical binding]; other site 251221003849 Q-loop/lid; other site 251221003850 ABC transporter signature motif; other site 251221003851 Walker B; other site 251221003852 D-loop; other site 251221003853 H-loop/switch region; other site 251221003854 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_Nitrate-R-NapA-like; cd02754 251221003855 formate dehydrogenase, alpha subunit, archaeal-type; Region: Fdh-alpha; TIGR01591 251221003856 [4Fe-4S] binding site [ion binding]; other site 251221003857 molybdopterin cofactor binding site; other site 251221003858 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_CT_Nitrate-R-NapA-like; cd02791 251221003859 molybdopterin cofactor binding site; other site 251221003860 Globins are heme proteins, which bind and transport oxygen. This family summarizes a diverse set of homologous protein domains, including: (1) tetrameric vertebrate hemoglobins, which are the major protein component of erythrocytes and transport oxygen...; Region: globin; cd01040 251221003861 heme-binding site [chemical binding]; other site 251221003862 PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812 251221003863 FOG: HEAT repeat [Energy production and conversion]; Region: COG1413 251221003864 PBS lyase HEAT-like repeat; Region: HEAT_PBS; cl15388 251221003865 Domain of unknown function (DUF3598); Region: DUF3598; pfam12204 251221003866 UbiA prenyltransferase family; Region: UbiA; cl00337 251221003867 Protein of unknown function (DUF721); Region: DUF721; cl02324 251221003868 GTP cyclohydrolase I (GTP-CH-I) catalyzes the conversion of GTP into dihydroneopterin triphosphate. The enzyme product is the precursor of tetrahydrofolate in eubacteria, fungi, and plants and of the folate analogs in methanogenic bacteria. In...; Region: GTP_cyclohydro1; cd00642 251221003869 homodecamer interface [polypeptide binding]; other site 251221003870 GTP cyclohydrolase I; Provisional; Region: PLN03044 251221003871 active site 251221003872 putative catalytic site residues [active] 251221003873 zinc binding site [ion binding]; other site 251221003874 GTP-CH-I/GFRP interaction surface; other site 251221003875 3-hydroxybutyrate dehydrogenase; Region: PHB_DH; TIGR01963 251221003876 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 251221003877 NADH dehydrogenase; Region: NADHdh; cl00469 251221003878 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 251221003879 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 251221003880 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 251221003881 dimer interface [polypeptide binding]; other site 251221003882 phosphorylation site [posttranslational modification] 251221003883 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 251221003884 ATP binding site [chemical binding]; other site 251221003885 Mg2+ binding site [ion binding]; other site 251221003886 G-X-G motif; other site 251221003887 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 251221003888 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 251221003889 active site 251221003890 phosphorylation site [posttranslational modification] 251221003891 intermolecular recognition site; other site 251221003892 dimerization interface [polypeptide binding]; other site 251221003893 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 251221003894 DNA binding residues [nucleotide binding] 251221003895 dimerization interface [polypeptide binding]; other site 251221003896 Sulfatase; Region: Sulfatase; cl10460 251221003897 Sulfatase; Region: Sulfatase; cl10460 251221003898 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 251221003899 putative active site [active] 251221003900 Alpha amylase catalytic domain found in an uncharacterized protein family; Region: AmyAc_5; cd11352 251221003901 active site 251221003902 catalytic site [active] 251221003903 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 251221003904 catalytic core [active] 251221003905 Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP; cd07040 251221003906 transaldolase/EF-hand domain-containing protein; Provisional; Region: PRK12309 251221003907 Transaldolases including both TalA and TalB; Region: Transaldolase_TalAB; cd00957 251221003908 active site 251221003909 dimer interface [polypeptide binding]; other site 251221003910 catalytic residue [active] 251221003911 EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to...; Region: EFh; cd00051 251221003912 Ca2+ binding site [ion binding]; other site 251221003913 Protein of unknown function (DUF1269); Region: DUF1269; cl01978 251221003914 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 251221003915 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 251221003916 23S rRNA interface [nucleotide binding]; other site 251221003917 L7/L12 interface [polypeptide binding]; other site 251221003918 putative thiostrepton binding site; other site 251221003919 L25 interface [polypeptide binding]; other site 251221003920 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 251221003921 mRNA/rRNA interface [nucleotide binding]; other site 251221003922 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 251221003923 23S rRNA interface [nucleotide binding]; other site 251221003924 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 251221003925 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 251221003926 L11 interface [polypeptide binding]; other site 251221003927 putative EF-Tu interaction site [polypeptide binding]; other site 251221003928 putative EF-G interaction site [polypeptide binding]; other site 251221003929 inosine 5-monophosphate dehydrogenase; Validated; Region: PRK08649 251221003930 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of the guanine...; Region: IMPDH; cd00381 251221003931 active site 251221003932 Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695 251221003933 acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654 251221003934 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cl14780 251221003935 Protein of unknown function (DUF3067); Region: DUF3067; pfam11267 251221003936 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 251221003937 putative active site [active] 251221003938 DNA polymerase III, subunit gamma and tau; Region: dnaX_nterm; TIGR02397 251221003939 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 251221003940 Walker A motif; other site 251221003941 ATP binding site [chemical binding]; other site 251221003942 Walker B motif; other site 251221003943 arginine finger; other site 251221003944 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 251221003945 DNA polymerase III subunits gamma and tau; Provisional; Region: PRK14948 251221003946 TonB-dependent heme/hemoglobin receptor family protein; Region: TonB-hemin; TIGR01785 251221003947 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 251221003948 N-terminal plug; other site 251221003949 ligand-binding site [chemical binding]; other site 251221003950 Integrase core domain; Region: rve; cl01316 251221003951 Transposase; Region: HTH_Tnp_IS630; pfam01710 251221003952 CpeS-like protein; Region: CpeS; pfam09367 251221003953 Mechanosensitive ion channel; Region: MS_channel; pfam00924 251221003954 RNB domain; Region: RNB; pfam00773 251221003955 This domain is the catalytic domain of ribonuclease II; Region: RNB; smart00955 251221003956 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cl00470 251221003957 Histone deacetylase domain; Region: Hist_deacetyl; cl02986 251221003958 RNA polymerase Rpb6; Region: RNA_pol_Rpb6; cl14651 251221003959 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 251221003960 catalytic site [active] 251221003961 G-X2-G-X-G-K; other site 251221003962 Fibronectin-binding protein A N-terminus (FbpA); Region: FbpA; pfam05833 251221003963 Domain of unknown function (DUF814); Region: DUF814; pfam05670 251221003964 Nucleotidyl transferase of unknown function (DUF1814); Region: DUF1814; cl00973 251221003965 Peptidase family M48; Region: Peptidase_M48; cl12018 251221003966 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl12011 251221003967 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293 251221003968 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293 251221003969 CbiD; Region: CbiD; cl00828 251221003970 Caspase, interleukin-1 beta converting enzyme (ICE) homologues; Cysteine-dependent aspartate-directed proteases that mediate programmed cell death (apoptosis). Caspases are synthesized as inactive zymogens and activated by proteolysis of the peptide...; Region: CASc; cl00042 251221003971 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 251221003972 structural tetrad; other site 251221003973 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 251221003974 structural tetrad; other site 251221003975 FOG: WD40 repeat [General function prediction only]; Region: COG2319 251221003976 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 251221003977 Precorrin-6x reductase CbiJ/CobK; Region: CbiJ; cl00922 251221003978 Precorrin-6x reductase [Coenzyme metabolism]; Region: CobK; COG2099 251221003979 TIGR03440 family protein; Region: unchr_TIGR03440 251221003980 DinB superfamily; Region: DinB_2; cl00986 251221003981 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; cl15394 251221003982 probable methyltransferase; Region: TIGR03438 251221003983 Uncharacterized conserved protein (DUF2260); Region: DUF2260; pfam10017 251221003984 Uncharacterized conserved protein (DUF2246); Region: DUF2246; pfam10229 251221003985 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 251221003986 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 251221003987 Coenzyme A binding pocket [chemical binding]; other site 251221003988 YjgH belongs to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgH_like; cd02198 251221003989 homotrimer interaction site [polypeptide binding]; other site 251221003990 putative active site [active] 251221003991 Predicted transcriptional regulator [Transcription]; Region: COG2944 251221003992 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 251221003993 non-specific DNA binding site [nucleotide binding]; other site 251221003994 salt bridge; other site 251221003995 sequence-specific DNA binding site [nucleotide binding]; other site 251221003996 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 251221003997 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 251221003998 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 251221003999 putative substrate binding region [chemical binding]; other site 251221004000 PCD_DCoH: The bifunctional protein pterin-4alpha-carbinolamine dehydratase (PCD), also known as DCoH (dimerization cofactor of hepatocyte nuclear factor-1), is both a transcription activator and a metabolic enzyme. DCoH stimulates gene expression by...; Region: PCD_DCoH; cd00488 251221004001 aromatic arch; other site 251221004002 DCoH dimer interaction site [polypeptide binding]; other site 251221004003 DCoH /HNF-1 dimer interaction site [polypeptide binding]; other site 251221004004 DCoH tetramer interaction site [polypeptide binding]; other site 251221004005 substrate binding site [chemical binding]; other site 251221004006 glycyl-tRNA synthetase subunit beta; Validated; Region: glyS; PRK01233 251221004007 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 251221004008 catalytic loop [active] 251221004009 iron binding site [ion binding]; other site 251221004010 Ycf46; Provisional; Region: ycf46; CHL00195 251221004011 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 251221004012 Walker A motif; other site 251221004013 ATP binding site [chemical binding]; other site 251221004014 Walker B motif; other site 251221004015 arginine finger; other site 251221004016 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 251221004017 binding surface 251221004018 TPR motif; other site 251221004019 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 251221004020 binding surface 251221004021 TPR motif; other site 251221004022 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 251221004023 S-adenosylmethionine binding site [chemical binding]; other site 251221004024 Amino acid permease; Region: AA_permease; cl00524 251221004025 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 251221004026 GAF domain; Region: GAF; cl00853 251221004027 putative PEP-CTERM system TPR-repeat lipoprotein; Region: PEP_TPR_lipo; TIGR02917 251221004028 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 251221004029 binding surface 251221004030 TPR motif; other site 251221004031 3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes [Amino acid transport and metabolism / Coenzyme metabolism]; Region: CysH; COG0175 251221004032 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 251221004033 Active Sites [active] 251221004034 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase contains two...; Region: OMP_decarboxylase_like; cd04725 251221004035 active site 251221004036 dimer interface [polypeptide binding]; other site 251221004037 Protein of unknown function (DUF1018); Region: DUF1018; cl01815 251221004038 bifunctional nicotinamide mononucleotide adenylyltransferase/ADP-ribose pyrophosphatase; Provisional; Region: PRK05379 251221004039 Nicotinamide/nicotinate mononucleotide adenylyltransferase of bifunctional proteins, also containing a Nudix hydrolase domain; Region: NMNAT_Nudix; cd02168 251221004040 active site 251221004041 (T/H)XGH motif; other site 251221004042 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 251221004043 nudix motif; other site 251221004044 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 251221004045 ligand binding site [chemical binding]; other site 251221004046 flexible hinge region; other site 251221004047 Signal transduction histidine kinase regulating phosphoglycerate transport system [Signal transduction mechanisms]; Region: COG4192 251221004048 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 251221004049 ATP binding site [chemical binding]; other site 251221004050 Mg2+ binding site [ion binding]; other site 251221004051 G-X-G motif; other site 251221004052 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 251221004053 ligand binding site [chemical binding]; other site 251221004054 flexible hinge region; other site 251221004055 Osmosensitive K+ channel histidine kinase [Signal transduction mechanisms]; Region: KdpD; COG2205 251221004056 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 251221004057 ATP binding site [chemical binding]; other site 251221004058 Mg2+ binding site [ion binding]; other site 251221004059 G-X-G motif; other site 251221004060 Zinc-dependent metalloprotease, pappalysin_like subfamily. The pregnancy-associated plasma protein A (PAPP-A or pappalysin-1) cleaves insulin-like growth factor-binding proteins 4 and 5, thereby promoting cell growth by releasing bound growth factor; Region: ZnMc_pappalysin_like; cd04275 251221004061 active site 251221004062 Protein of unknown function (DUF3110); Region: DUF3110; pfam11360 251221004063 EVE domain; Region: EVE; cl00728 251221004064 Amino acid permease; Region: AA_permease; cl00524 251221004065 muropeptide transporter; Validated; Region: ampG; PRK11010 251221004066 muropeptide transporter; Reviewed; Region: ampG; PRK11902 251221004067 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 251221004068 active site 251221004069 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 251221004070 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 251221004071 active site 251221004072 homodimer interface [polypeptide binding]; other site 251221004073 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 251221004074 GAF domain; Region: GAF; cl00853 251221004075 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cl00120 251221004076 Sodium:solute symporter family; Region: SSF; cl00456 251221004077 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 251221004078 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 251221004079 putative active site [active] 251221004080 Molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: DnaK; COG0443 251221004081 Plasmid stability protein [General function prediction only]; Region: StbC; COG4691 251221004082 PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881 251221004083 oligomeric interface; other site 251221004084 putative active site [active] 251221004085 homodimer interface [polypeptide binding]; other site 251221004086 PIN domain of the Pyrobaculum aerophilum Pae0151 and Pae2754 proteins and homologs; Region: PIN_Pae0151; cd09873 251221004087 putative active site [active] 251221004088 homotetrameric interface [polypeptide binding]; other site 251221004089 metal binding site [ion binding]; metal-binding site 251221004090 Phd_YefM; Region: PhdYeFM; cl09153 251221004091 agmatine deiminase; Region: agmatine_aguA; TIGR03380 251221004092 N-carbamoylputrescine amidohydrolase (CPA) (class 11 nitrilases); Region: CPA; cd07573 251221004093 N-carbamolyputrescine amidase; Region: PLN02747 251221004094 putative active site; other site 251221004095 catalytic triad [active] 251221004096 putative dimer interface [polypeptide binding]; other site 251221004097 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 251221004098 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 251221004099 active site 251221004100 phosphorylation site [posttranslational modification] 251221004101 intermolecular recognition site; other site 251221004102 dimerization interface [polypeptide binding]; other site 251221004103 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 251221004104 DNA binding residues [nucleotide binding] 251221004105 dimerization interface [polypeptide binding]; other site 251221004106 Response regulator receiver domain; Region: Response_reg; pfam00072 251221004107 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 251221004108 active site 251221004109 phosphorylation site [posttranslational modification] 251221004110 intermolecular recognition site; other site 251221004111 dimerization interface [polypeptide binding]; other site 251221004112 HD superfamily phosphohydrolases [General function prediction only]; Region: COG1078 251221004113 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 251221004114 heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386 251221004115 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 251221004116 dimer interface [polypeptide binding]; other site 251221004117 phosphorylation site [posttranslational modification] 251221004118 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 251221004119 ATP binding site [chemical binding]; other site 251221004120 Mg2+ binding site [ion binding]; other site 251221004121 G-X-G motif; other site 251221004122 CpxP component of the bacterial Cpx-two-component system and related proteins; Region: CpxP_like; cd09916 251221004123 dimer interface [polypeptide binding]; other site 251221004124 Ribose/Galactose Isomerase; Region: LacAB_rpiB; cl00485 251221004125 isoform II; Region: PAF-AH_p_II; pfam03403 251221004126 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 251221004127 Putative addiction module component; Region: Unstab_antitox; cl09921 251221004128 Plasmid stabilisation system protein; Region: Plasmid_stabil; cl11422 251221004129 glucose-6-phosphate isomerase; Reviewed; Region: pgi; PRK00179 251221004130 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 251221004131 active site 251221004132 dimer interface [polypeptide binding]; other site 251221004133 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 251221004134 dimer interface [polypeptide binding]; other site 251221004135 active site 251221004136 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462 251221004137 ABC-ATPase subunit interface; other site 251221004138 dimer interface [polypeptide binding]; other site 251221004139 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 251221004140 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 251221004141 intersubunit interface [polypeptide binding]; other site 251221004142 PIN domains of VapC and Smg6 ribonucleases, ribosome assembly factor NOB1, Archaeoglobus fulgidus AF0591 protein and homologs; Region: PIN_VapC-Smg6-like; cd09855 251221004143 putative active site [active] 251221004144 Ion channel; Region: Ion_trans_2; cl11596 251221004145 Protein-L-isoaspartate carboxylmethyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: Pcm; COG2518 251221004146 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 251221004147 S-adenosylmethionine binding site [chemical binding]; other site 251221004148 Predicted glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: ECM4; COG0435 251221004149 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 251221004150 C-terminal, alpha helical domain of Class Omega-like Glutathione S-transferases; Region: GST_C_Omega_like; cd03190 251221004151 putative dimer interface [polypeptide binding]; other site 251221004152 N-terminal domain interface [polypeptide binding]; other site 251221004153 putative substrate binding pocket (H-site) [chemical binding]; other site 251221004154 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 251221004155 putative active site [active] 251221004156 GSH-dependent disulfide bond oxidoreductase; Provisional; Region: PRK13972 251221004157 GST_N family, Ure2p-like subfamily; composed of the Saccharomyces cerevisiae Ure2p and related GSTs. Ure2p is a regulator for nitrogen catabolism in yeast. It represses the expression of several gene products involved in the use of poor nitrogen sources...; Region: GST_N_Ure2p_like; cd03048 251221004158 C-terminal domain interface [polypeptide binding]; other site 251221004159 GSH binding site (G-site) [chemical binding]; other site 251221004160 dimer interface [polypeptide binding]; other site 251221004161 C-terminal, alpha helical domain of Escherichia coli YfcG Glutathione S-transferases and related uncharacterized proteins; Region: GST_C_YfcG_like; cd10291 251221004162 N-terminal domain interface [polypeptide binding]; other site 251221004163 putative dimer interface [polypeptide binding]; other site 251221004164 active site 251221004165 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506 251221004166 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 251221004167 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 251221004168 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 251221004169 D1, D2 subunits of photosystem II (PSII); M, L subunits of bacterial photosynthetic reaction center; Region: Photo_RC; cl08220 251221004170 pheophytin binding site; other site 251221004171 chlorophyll binding site; other site 251221004172 quinone binding site; other site 251221004173 Fe binding site [ion binding]; other site 251221004174 YceI-like domain; Region: YceI; cl01001 251221004175 PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812 251221004176 Regulators of stationary/sporulation gene expression [Transcription]; Region: AbrB; COG2002 251221004177 SpoVT / AbrB like domain; Region: SpoVT_AbrB; cl00877 251221004178 geranylgeranyl reductase family; Region: GG-red-SF; TIGR02032 251221004179 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 251221004180 Uncharacterized homologs of Site-2 protease (S2P), zinc metalloproteases (MEROPS family M50) which cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of the...; Region: S2P-M50_like_2; cd06160 251221004181 active site 251221004182 putative substrate binding region [chemical binding]; other site 251221004183 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 251221004184 magnesium chelatase ATPase subunit I; Region: BchI-ChlI; TIGR02030 251221004185 YCII-related domain; Region: YCII; cl00999 251221004186 anthranilate synthase component I; Provisional; Region: PRK13565 251221004187 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 251221004188 chorismate binding enzyme; Region: Chorismate_bind; cl10555 251221004189 TRX-like protein A (TxlA) family; TxlA was originally isolated from the cyanobacterium Synechococcus. It is found only in oxygenic photosynthetic organisms. TRX is a small enzyme that participate in redox reactions, via the reversible oxidation of an...; Region: TxlA; cd02950 251221004190 catalytic residues [active] 251221004191 LysE type translocator; Region: LysE; cl00565 251221004192 Saccharopine dehydrogenase and related proteins [Amino acid transport and metabolism]; Region: LYS9; COG1748 251221004193 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 251221004194 NAD(P) binding site [chemical binding]; other site 251221004195 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 251221004196 PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812 251221004197 Helix-turn-helix domains; Region: HTH; cl00088 251221004198 Transposase; Region: HTH_Tnp_IS630; pfam01710 251221004199 Integrase core domain; Region: rve; cl01316 251221004200 Beta-carotene ketolase/oxygenase (CrtW, also known as CrtO), the carotenoid astaxanthin biosynthetic enzyme, initially catalyzes the addition of two keto groups to carbons C4 and C4' of beta-carotene. Carotenoids are important natural pigments produced...; Region: CrtW_beta-carotene-ketolase; cd03513 251221004201 Fatty acid desaturase; Region: FA_desaturase; pfam00487 251221004202 putative di-iron ligands [ion binding]; other site 251221004203 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 251221004204 active site 251221004205 catalytic residues [active] 251221004206 metal binding site [ion binding]; metal-binding site 251221004207 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 251221004208 TM-ABC transporter signature motif; other site 251221004209 Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571 251221004210 putative active site [active] 251221004211 catalytic triad [active] 251221004212 putative dimer interface [polypeptide binding]; other site 251221004213 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 251221004214 binding surface 251221004215 TPR motif; other site 251221004216 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl15700 251221004217 Sugar fermentation stimulation protein; Region: SfsA; cl00647 251221004218 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 251221004219 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 251221004220 Anti-sigma-K factor rskA; Region: RskA; cl15366 251221004221 RNA polymerase sigma factor RpoE; Provisional; Region: PRK09652 251221004222 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 251221004223 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 251221004224 DNA binding residues [nucleotide binding] 251221004225 Protein of unknown function (DUF3464); Region: DUF3464; pfam11947 251221004226 3-deoxy-7-phosphoheptulonate synthase; Provisional; Region: PRK13396 251221004227 NeuB family; Region: NeuB; cl00496 251221004228 Protein of unknown function (DUF2854); Region: DUF2854; pfam11016 251221004229 Trans-Isoprenyl Diphosphate Synthases, head-to-head; Region: Trans_IPPS_HH; cd00683 251221004230 active site lid residues [active] 251221004231 substrate binding pocket [chemical binding]; other site 251221004232 catalytic residues [active] 251221004233 substrate-Mg2+ binding site; other site 251221004234 aspartate-rich region 1; other site 251221004235 aspartate-rich region 2; other site 251221004236 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641 251221004237 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641 251221004238 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 251221004239 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 251221004240 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 251221004241 hopanoid-associated sugar epimerase; Region: HpnA; TIGR03466 251221004242 uncharacterized subgroup of aldehyde reductase and flavonoid reductase related proteins, extended (e) SDRs; Region: AR_FR_like_1_SDR_e; cd05228 251221004243 putative NADP binding site [chemical binding]; other site 251221004244 putative substrate binding site [chemical binding]; other site 251221004245 active site 251221004246 hopanoid biosynthesis associated radical SAM protein HpnH; Region: HpnH; TIGR03470 251221004247 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 251221004248 FeS/SAM binding site; other site 251221004249 Domain of unknown function (DUF3463); Region: DUF3463; pfam11946 251221004250 Deoxyribodipyrimidine photolyase [DNA replication, recombination, and repair]; Region: PhrB; COG0415 251221004251 DNA photolyase; Region: DNA_photolyase; pfam00875 251221004252 FAD binding domain of DNA photolyase; Region: FAD_binding_7; pfam03441 251221004253 Protein of unknown function (DUF2993); Region: DUF2993; pfam11209 251221004254 glycerol kinase; Region: glycerol_kin; TIGR01311 251221004255 Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786 251221004256 N- and C-terminal domain interface [polypeptide binding]; other site 251221004257 active site 251221004258 MgATP binding site [chemical binding]; other site 251221004259 catalytic site [active] 251221004260 metal binding site [ion binding]; metal-binding site 251221004261 glycerol binding site [chemical binding]; other site 251221004262 homotetramer interface [polypeptide binding]; other site 251221004263 homodimer interface [polypeptide binding]; other site 251221004264 FBP binding site [chemical binding]; other site 251221004265 protein IIAGlc interface [polypeptide binding]; other site 251221004266 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 251221004267 catalytic core [active] 251221004268 Tic22-like family; Region: Tic22; cl04468 251221004269 Tic22-like family; Region: Tic22; cl04468 251221004270 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 251221004271 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 251221004272 S-adenosylmethionine binding site [chemical binding]; other site 251221004273 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 251221004274 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 251221004275 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 251221004276 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 251221004277 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 251221004278 N-Dimethylarginine dimethylaminohydrolase [Amino acid transport and metabolism]; Region: COG1834 251221004279 Amidinotransferase; Region: Amidinotransf; cl12043 251221004280 TIGR00300 family protein; Region: TIGR00300 251221004281 LOR/SDH bifunctional enzyme conserved region; Region: Saccharop_dh_N; pfam04455 251221004282 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 251221004283 NhaP-type Na+/H+ and K+/H+ antiporters with a unique C-terminal domain [Inorganic ion transport and metabolism]; Region: COG3263 251221004284 Nickel uptake substrate-specific transmembrane region; Region: NikM; pfam10670 251221004285 ABC-type Co2+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: CbiK; COG5266 251221004286 Predicted Rossmann fold nucleotide-binding protein involved in DNA uptake [DNA replication, recombination, and repair / Intracellular trafficking and secretion]; Region: Smf; COG0758 251221004287 Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695 251221004288 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 251221004289 nucleoside/Zn binding site; other site 251221004290 dimer interface [polypeptide binding]; other site 251221004291 catalytic motif [active] 251221004292 Domain of unknown function (DUF4394); Region: DUF4394; pfam14339 251221004293 RNA polymerase sigma factor; Provisional; Region: PRK12519 251221004294 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 251221004295 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 251221004296 DNA binding residues [nucleotide binding] 251221004297 Anti-sigma-K factor rskA; Region: RskA; cl15366 251221004298 Domain of unknown function (DUF4394); Region: DUF4394; pfam14339 251221004299 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 251221004300 PAS fold; Region: PAS_4; pfam08448 251221004301 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 251221004302 GAF domain; Region: GAF; cl00853 251221004303 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 251221004304 PAS fold; Region: PAS_4; pfam08448 251221004305 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 251221004306 Histidine kinase; Region: HisKA_2; cl06527 251221004307 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 251221004308 ATP binding site [chemical binding]; other site 251221004309 Mg2+ binding site [ion binding]; other site 251221004310 G-X-G motif; other site 251221004311 Response regulator receiver domain; Region: Response_reg; pfam00072 251221004312 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 251221004313 active site 251221004314 phosphorylation site [posttranslational modification] 251221004315 intermolecular recognition site; other site 251221004316 dimerization interface [polypeptide binding]; other site 251221004317 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 251221004318 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cl00047 251221004319 Helix-turn-helix domains; Region: HTH; cl00088 251221004320 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 251221004321 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 251221004322 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087 251221004323 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 251221004324 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087 251221004325 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 251221004326 IMP binding site; other site 251221004327 dimer interface [polypeptide binding]; other site 251221004328 PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812 251221004329 cobyric acid synthase; Provisional; Region: PRK00784 251221004330 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 251221004331 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 251221004332 catalytic triad [active] 251221004333 aspartate kinase; Region: asp_kinases; TIGR00657 251221004334 Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452 251221004335 aspartate kinase; Region: asp_kinases; TIGR00657 251221004336 Uncharacterized flavoproteins [Energy production and conversion]; Region: FpaA; COG0426 251221004337 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 251221004338 Flavin Reductases; Region: FlaRed; cl00801 251221004339 Uncharacterized flavoproteins [Energy production and conversion]; Region: FpaA; COG0426 251221004340 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 251221004341 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 251221004342 Flavin Reductases; Region: FlaRed; cl00801 251221004343 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 251221004344 Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as Transcription factor ImmunoGlobin (TIG) domains. They are present in intracellular transcription factors, cell surface receptors (such as plexins and scatter factor...; Region: IPT; cl15674 251221004345 Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; pfam04230 251221004346 UDP-N-acetylenolpyruvoylglucosamine reductase; Region: murB; TIGR00179 251221004347 FAD binding domain; Region: FAD_binding_4; pfam01565 251221004348 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 251221004349 colanic acid exporter; Provisional; Region: PRK10459 251221004350 MatE; Region: MatE; cl10513 251221004351 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 251221004352 NTP_transferases catalyze the transfer of nucleotides onto phosphosugars; Region: NTP_transferase; cd04181 251221004353 active site 251221004354 Substrate binding site; other site 251221004355 Mg++ binding site; other site 251221004356 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 251221004357 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538 251221004358 glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207 251221004359 substrate binding site; other site 251221004360 tetramer interface; other site 251221004361 Alpha-L-arabinofuranosidase [Carbohydrate transport and metabolism]; Region: AbfA; COG3534 251221004362 serine O-acetyltransferase; Region: cysE; TIGR01172 251221004363 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 251221004364 trimer interface [polypeptide binding]; other site 251221004365 active site 251221004366 substrate binding site [chemical binding]; other site 251221004367 CoA binding site [chemical binding]; other site 251221004368 Glycosyl transferase 4-like domain; Region: Glyco_trans_4_4; cl15759 251221004369 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 251221004370 Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as Transcription factor ImmunoGlobin (TIG) domains. They are present in intracellular transcription factors, cell surface receptors (such as plexins and scatter factor...; Region: IPT; cl15674 251221004371 Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as Transcription factor ImmunoGlobin (TIG) domains. They are present in intracellular transcription factors, cell surface receptors (such as plexins and scatter factor...; Region: IPT; cl15674 251221004372 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 251221004373 This family is most closely related to the GT1 family of glycosyltransferases. wlbH in Bordetella parapertussis has been shown to be required for the biosynthesis of a trisaccharide that, when attached to the B. pertussis lipopolysaccharide (LPS) core; Region: GT1_wlbH_like; cd03798 251221004374 Bacterial sugar transferase; Region: Bac_transf; cl00939 251221004375 MatE; Region: MatE; cl10513 251221004376 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 251221004377 active site 251221004378 O-Antigen ligase; Region: Wzy_C; cl04850 251221004379 Uncharacterized protein involved in exopolysaccharide biosynthesis [Cell envelope biogenesis, outer membrane]; Region: GumC; COG3206 251221004380 Chain length determinant protein; Region: Wzz; cl01623 251221004381 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Mrp; COG0489 251221004382 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 251221004383 Nucleotide binding site [chemical binding]; other site 251221004384 P loop; other site 251221004385 DTAP/Switch II; other site 251221004386 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 251221004387 polysaccharide export protein Wza; Provisional; Region: PRK15078 251221004388 Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004 251221004389 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 251221004390 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 251221004391 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 251221004392 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 251221004393 DNA binding residues [nucleotide binding] 251221004394 dimerization interface [polypeptide binding]; other site 251221004395 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 251221004396 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 251221004397 Uncharacterised BCR, COG1649; Region: DUF187; cl15398 251221004398 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 251221004399 D-alanyl-D-alanine carboxypeptidase; Region: VanY; cl00813 251221004400 bifunctional pantoate ligase/cytidylate kinase; Provisional; Region: PRK13477 251221004401 Pantoate-beta-alanine ligase; Region: PanC; cd00560 251221004402 active site 251221004403 ATP-binding site [chemical binding]; other site 251221004404 pantoate-binding site; other site 251221004405 HXXH motif; other site 251221004406 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 251221004407 CMP-binding site; other site 251221004408 The sites determining sugar specificity; other site 251221004409 Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728 251221004410 ThiS interaction site; other site 251221004411 putative active site [active] 251221004412 tetramer interface [polypeptide binding]; other site 251221004413 Helix-turn-helix domains; Region: HTH; cl00088 251221004414 DNA polymerase III subunits gamma and tau; Provisional; Region: PRK14951 251221004415 UbiA prenyltransferase family; Region: UbiA; cl00337 251221004416 Domain of unknown function DUF140; Region: DUF140; cl00510 251221004417 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 251221004418 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 251221004419 active site 251221004420 phosphorylation site [posttranslational modification] 251221004421 intermolecular recognition site; other site 251221004422 dimerization interface [polypeptide binding]; other site 251221004423 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 251221004424 DNA binding site [nucleotide binding] 251221004425 Protein of unknown function (DUF3667); Region: DUF3667; pfam12412 251221004426 NnrS protein; Region: NnrS; cl01258 251221004427 heat shock protein 90; Provisional; Region: PRK05218 251221004428 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 251221004429 ATP binding site [chemical binding]; other site 251221004430 Mg2+ binding site [ion binding]; other site 251221004431 G-X-G motif; other site 251221004432 Gram-negative bacterial tonB protein; Region: TonB; cl10048 251221004433 GAF domain; Region: GAF; cl00853 251221004434 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 251221004435 dimer interface [polypeptide binding]; other site 251221004436 phosphorylation site [posttranslational modification] 251221004437 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 251221004438 ATP binding site [chemical binding]; other site 251221004439 Mg2+ binding site [ion binding]; other site 251221004440 G-X-G motif; other site 251221004441 maltose O-acetyltransferase; Provisional; Region: PRK10092 251221004442 Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357 251221004443 active site 251221004444 substrate binding site [chemical binding]; other site 251221004445 trimer interface [polypeptide binding]; other site 251221004446 CoA binding site [chemical binding]; other site 251221004447 Peptide methionine sulfoxide reductase; Region: PMSR; cl00366 251221004448 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 251221004449 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 251221004450 minor groove reading motif; other site 251221004451 helix-hairpin-helix signature motif; other site 251221004452 substrate binding pocket [chemical binding]; other site 251221004453 active site 251221004454 Helix-turn-helix domains; Region: HTH; cl00088 251221004455 Pirin-related protein [General function prediction only]; Region: COG1741 251221004456 Cupin domain; Region: Cupin_2; cl09118 251221004457 Plasmid stabilisation system protein; Region: Plasmid_stabil; cl11422 251221004458 Ribbon-helix-helix protein, copG family; Region: RHH_1; cl15375 251221004459 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 251221004460 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137 251221004461 conserved cys residue [active] 251221004462 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 251221004463 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 251221004464 ligand binding site [chemical binding]; other site 251221004465 elongation factor Ts; Reviewed; Region: tsf; PRK12332 251221004466 Ubiquitin Associated domain. The UBA domain is a commonly occurring sequence motif in some members of the ubiquitination pathway, UV excision repair proteins, and certain protein kinases. Although its specific role is so far unknown, it has been...; Region: UBA; cl00153 251221004467 Elongation factor TS; Region: EF_TS; pfam00889 251221004468 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cl00315 251221004469 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 251221004470 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 251221004471 putative active site [active] 251221004472 substrate binding site [chemical binding]; other site 251221004473 putative cosubstrate binding site; other site 251221004474 catalytic site [active] 251221004475 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 251221004476 substrate binding site [chemical binding]; other site 251221004477 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 251221004478 Ligand Binding Site [chemical binding]; other site 251221004479 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 251221004480 Ligand Binding Site [chemical binding]; other site 251221004481 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 251221004482 Domain of unknown function DUF21; Region: DUF21; pfam01595 251221004483 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 251221004484 Transporter associated domain; Region: CorC_HlyC; cl08393 251221004485 preprotein translocase subunit SecA; Reviewed; Region: secA; PRK12902 251221004486 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 251221004487 SecA preprotein cross-linking domain; Region: SecA_PP_bind; cl03078 251221004488 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 251221004489 Transposase; Region: DDE_Tnp_ISL3; pfam01610 251221004490 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 251221004491 FG-GAP repeat; Region: FG-GAP; cl15299 251221004492 FG-GAP repeat; Region: FG-GAP; cl15299 251221004493 FG-GAP repeat; Region: FG-GAP; cl15299 251221004494 FG-GAP repeat; Region: FG-GAP; cl15299 251221004495 FG-GAP repeat; Region: FG-GAP; cl15299 251221004496 TIGR03032 family protein; Region: TIGR03032 251221004497 Domain of unknown function (DUF4276); Region: DUF4276; pfam14103 251221004498 Predicted ATPase [General function prediction only]; Region: COG4637 251221004499 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 251221004500 Walker A/P-loop; other site 251221004501 ATP binding site [chemical binding]; other site 251221004502 Q-loop/lid; other site 251221004503 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 251221004504 ABC transporter signature motif; other site 251221004505 Walker B; other site 251221004506 D-loop; other site 251221004507 H-loop/switch region; other site 251221004508 The band 7 domain of flotillin (reggie) like proteins. This group contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual proteins of this...; Region: Band_7; cl02525 251221004509 The band 7 domain of flotillin (reggie) like proteins. This group contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual proteins of this...; Region: Band_7; cl02525 251221004510 SERine Proteinase INhibitors (serpins), prokaryotic subgroup. Little information about specific functions is available for this subgroup, most likely they are inhibitory members of the serpin superfamily. In general, serpins exhibit conformational...; Region: bacterial_SERPIN; cd02049 251221004511 reactive center loop; other site 251221004512 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149 251221004513 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 251221004514 protein binding site [polypeptide binding]; other site 251221004515 sulfite reductase subunit beta; Provisional; Region: PRK13504 251221004516 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 251221004517 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 251221004518 CAAX amino terminal protease self- immunity; Region: Abi; cl00558 251221004519 Poly(3-hydroxybutyrate) depolymerase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: LpqC; COG3509 251221004520 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 251221004521 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 251221004522 CheB methylesterase; Region: CheB_methylest; pfam01339 251221004523 Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352 251221004524 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 251221004525 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl12011 251221004526 Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196 251221004527 PAS fold; Region: PAS_4; pfam08448 251221004528 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 251221004529 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 251221004530 dimer interface [polypeptide binding]; other site 251221004531 phosphorylation site [posttranslational modification] 251221004532 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 251221004533 ATP binding site [chemical binding]; other site 251221004534 Mg2+ binding site [ion binding]; other site 251221004535 G-X-G motif; other site 251221004536 excinuclease ABC subunit B; Provisional; Region: PRK05298 251221004537 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 251221004538 ATP binding site [chemical binding]; other site 251221004539 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 251221004540 nucleotide binding region [chemical binding]; other site 251221004541 ATP-binding site [chemical binding]; other site 251221004542 Ultra-violet resistance protein B; Region: UvrB; pfam12344 251221004543 ScpA/B protein; Region: ScpA_ScpB; cl00598 251221004544 Putative transcriptional regulators (Ypuh-like); Region: DUF387; cl00612 251221004545 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 251221004546 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 251221004547 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; cl11611 251221004548 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 251221004549 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 251221004550 inhibitor-cofactor binding pocket; inhibition site 251221004551 pyridoxal 5'-phosphate binding site [chemical binding]; other site 251221004552 catalytic residue [active] 251221004553 Uncharacterised ACR, COG1259; Region: DUF151; cl00553 251221004554 Surface antigen variable number repeat; Region: Surf_Ag_VNR; cl10520 251221004555 Surface antigen variable number repeat; Region: Surf_Ag_VNR; cl10520 251221004556 Surface antigen; Region: Bac_surface_Ag; cl03097 251221004557 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Provisional; Region: lpxD; PRK00892 251221004558 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase, LpxD; Region: LpxD; pfam04613 251221004559 UDP-3-O-acyl-glucosamine N-acyltransferase (LpxD): The enzyme catalyzes the transfer of 3-hydroxymyristic acid or 3-hydroxy-arachidic acid, depending on the organism, from the acyl carrier protein (ACP) to UDP-3-O-acyl-glucosamine to produce UDP-2; Region: LbH_LpxD; cd03352 251221004560 trimer interface [polypeptide binding]; other site 251221004561 active site 251221004562 UDP-GlcNAc binding site [chemical binding]; other site 251221004563 lipid binding site [chemical binding]; lipid-binding site 251221004564 UDP-3-O-acyl N-acetylglycosamine deacetylase; Region: LpxC; pfam03331 251221004565 UDP-3-O-acyl-N-acetylglucosamine deacetylase [Cell envelope biogenesis, outer membrane]; Region: LpxC; cl00512 251221004566 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 251221004567 UDP-N-acetylglucosamine acyltransferase; Provisional; Region: PRK05289 251221004568 UDP-N-acetylglucosamine O-acyltransferase (UDP-GlcNAc acyltransferase): Proteins in this family catalyze the transfer of (R)-3-hydroxymyristic acid from its acyl carrier protein thioester to UDP-GlcNAc. It is the first enzyme in the lipid A biosynthetic...; Region: LbH_UDP-GlcNAc_AT; cd03351 251221004569 active site 251221004570 lipid-A-disaccharide synthase; Reviewed; Region: lpxB; PRK00025 251221004571 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 251221004572 Cytochrome b(C-terminus)/b6/petD: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: cytochrome_b_C; cl00193 251221004573 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859 251221004574 interchain domain interface [polypeptide binding]; other site 251221004575 intrachain domain interface; other site 251221004576 heme bL binding site [chemical binding]; other site 251221004577 heme bH binding site [chemical binding]; other site 251221004578 Qo binding site; other site 251221004579 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 251221004580 Enterobacter aerogenes GpdQ and related proteins, metallophosphatase domain; Region: MPP_GpdQ; cd07402 251221004581 active site 251221004582 metal binding site [ion binding]; metal-binding site 251221004583 hexamer interface [polypeptide binding]; other site 251221004584 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 251221004585 catalytic core [active] 251221004586 Protein of unknown function (DUF2499); Region: DUF2499; pfam10693 251221004587 Competence protein; Region: Competence; cl00471 251221004588 Domain of unknown function DUF20; Region: UPF0118; cl00465 251221004589 Uncharacterized conserved protein [Function unknown]; Region: COG1912 251221004590 S-adenosyl-l-methionine hydroxide adenosyltransferase; Region: SAM_adeno_trans; pfam01887 251221004591 oxidoreductase alpha (molybdopterin) subunit; Region: Fdhalpha-like; TIGR01701 251221004592 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 251221004593 molybdopterin cofactor binding site; other site 251221004594 Molybdopterin-Binding, C-terminal (MopB_CT) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum-...; Region: MopB_CT; cl09929 251221004595 molybdopterin cofactor binding site; other site 251221004596 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 251221004597 putative active site [active] 251221004598 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14186 251221004599 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 251221004600 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 251221004601 homodimer interface [polypeptide binding]; other site 251221004602 NADP binding site [chemical binding]; other site 251221004603 substrate binding site [chemical binding]; other site 251221004604 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 251221004605 This family is most closely related to the GT1 family of glycosyltransferases. aviGT4 in Streptomyces viridochromogenes has been shown to be involved in biosynthesis of oligosaccharide antibiotic avilamycin A. Inactivation of aviGT4 resulted in a mutant...; Region: GT1_AviGT4_like; cd03802 251221004606 putative ADP-binding pocket [chemical binding]; other site 251221004607 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 251221004608 binding surface 251221004609 TPR motif; other site 251221004610 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 251221004611 binding surface 251221004612 TPR motif; other site 251221004613 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 251221004614 binding surface 251221004615 TPR motif; other site 251221004616 CHAT domain; Region: CHAT; cl02083 251221004617 Fatty acyltransferase-like subfamily of the SGNH hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its...; Region: fatty_acyltransferase_like; cd01846 251221004618 active site 251221004619 catalytic triad [active] 251221004620 oxyanion hole [active] 251221004621 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 251221004622 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 251221004623 Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic...; Region: GST_N_family; cd00570 251221004624 C-terminal domain interface [polypeptide binding]; other site 251221004625 GSH binding site (G-site) [chemical binding]; other site 251221004626 dimer interface [polypeptide binding]; other site 251221004627 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776 251221004628 N-terminal domain interface [polypeptide binding]; other site 251221004629 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 251221004630 active site 251221004631 catalytic tetrad [active] 251221004632 Domain of unknown function (DUF4385); Region: DUF4385; pfam14328 251221004633 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 251221004634 putative active site [active] 251221004635 Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175 251221004636 Clavaminic acid synthetase (CAS) -like; CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cl00184 251221004637 active site 251221004638 iron coordination sites [ion binding]; other site 251221004639 substrate binding pocket [chemical binding]; other site 251221004640 Sulfotransferase family; Region: Sulfotransfer_3; cl14559 251221004641 Sulfotransferase family; Region: Sulfotransfer_3; cl14559 251221004642 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 251221004643 binding surface 251221004644 TPR motif; other site 251221004645 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 251221004646 binding surface 251221004647 TPR motif; other site 251221004648 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2976 251221004649 Sulfatase; Region: Sulfatase; cl10460 251221004650 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 251221004651 Glucose/sorbosone dehydrogenases [Carbohydrate transport and metabolism]; Region: COG2133 251221004652 NHL repeat; Region: NHL; pfam01436 251221004653 Cytochrome c; Region: Cytochrom_C; cl11414 251221004654 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 251221004655 putative active site [active] 251221004656 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 251221004657 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 251221004658 N-terminal plug; other site 251221004659 ligand-binding site [chemical binding]; other site 251221004660 Plasmid stabilisation system protein; Region: Plasmid_stabil; cl11422 251221004661 Sec-independent protein translocase protein (TatC); Region: TatC; cl00521 251221004662 Domain of unknown function DUF37; Region: DUF37; cl00506 251221004663 Protein of unknown function (DUF3148); Region: DUF3148; pfam11347 251221004664 patatin-related protein; Region: TIGR03607 251221004665 bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415 251221004666 phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362 251221004667 ATP binding site [chemical binding]; other site 251221004668 active site 251221004669 substrate binding site [chemical binding]; other site 251221004670 FtsH Extracellular; Region: FtsH_ext; pfam06480 251221004671 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 251221004672 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 251221004673 Walker A motif; other site 251221004674 ATP binding site [chemical binding]; other site 251221004675 Walker B motif; other site 251221004676 arginine finger; other site 251221004677 Peptidase family M41; Region: Peptidase_M41; pfam01434 251221004678 Cytochrome b(C-terminus)/b6/petD: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: cytochrome_b_C; cd00290 251221004679 interchain domain interface [polypeptide binding]; other site 251221004680 intrachain domain interface; other site 251221004681 Qi binding site; other site 251221004682 Qo binding site; other site 251221004683 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cd00284 251221004684 Qi binding site; other site 251221004685 intrachain domain interface; other site 251221004686 interchain domain interface [polypeptide binding]; other site 251221004687 heme bH binding site [chemical binding]; other site 251221004688 heme bL binding site [chemical binding]; other site 251221004689 Qo binding site; other site 251221004690 Rrf2 family protein; Region: rrf2_super; TIGR00738 251221004691 Helix-turn-helix domains; Region: HTH; cl00088 251221004692 Helix-turn-helix domains; Region: HTH; cl00088 251221004693 S-adenosyl-l-methionine hydroxide adenosyltransferase; Region: SAM_adeno_trans; pfam01887 251221004694 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 251221004695 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 251221004696 iron-sulfur cluster [ion binding]; other site 251221004697 [2Fe-2S] cluster binding site [ion binding]; other site 251221004698 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 251221004699 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 251221004700 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 251221004701 D-alanyl-D-alanine carboxypeptidase; Region: VanY; cl00813 251221004702 Predicted oxidoreductases (related to aryl-alcohol dehydrogenases) [Energy production and conversion]; Region: Tas; COG0667 251221004703 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 251221004704 active site 251221004705 catalytic tetrad [active] 251221004706 Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239 251221004707 MgtE intracellular N domain; Region: MgtE_N; cl15244 251221004708 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 251221004709 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 251221004710 Divalent cation transporter; Region: MgtE; cl00786 251221004711 Predicted ATPase [General function prediction only]; Region: COG4637 251221004712 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 251221004713 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 251221004714 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 251221004715 dimer interface [polypeptide binding]; other site 251221004716 anticodon binding site; other site 251221004717 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of the...; Region: AspRS_core; cd00777 251221004718 homodimer interface [polypeptide binding]; other site 251221004719 motif 1; other site 251221004720 active site 251221004721 motif 2; other site 251221004722 GAD domain; Region: GAD; pfam02938 251221004723 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it attaches...; Region: class_II_aaRS-like_core; cl00268 251221004724 active site 251221004725 motif 3; other site 251221004726 Uncharacterized ACR, COG1430; Region: DUF192; cl00627 251221004727 Phycobilisome protein; Region: Phycobilisome; cl08227 251221004728 Gluconolactonase [Carbohydrate transport and metabolism]; Region: COG3386 251221004729 PQQ-dependent catabolism-associated beta-propeller protein; Region: PQQ_ABC_repeats; TIGR03866 251221004730 Uncharacterized conserved protein [Function unknown]; Region: COG3391 251221004731 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 251221004732 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 251221004733 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 251221004734 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 251221004735 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 251221004736 Predicted thioesterase involved in non-ribosomal peptide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: GrsT; COG3208 251221004737 Cytochrome P450; Region: p450; cl12078 251221004738 Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane]; Region: Cfa; COG2230 251221004739 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 251221004740 S-adenosylmethionine binding site [chemical binding]; other site 251221004741 Phosphopantetheine attachment site; Region: PP-binding; cl09936 251221004742 The Delta9 Fatty Acid Desaturase (Delta9-FADS)-like CD includes the delta-9 and delta-11 acyl CoA desaturases found in various eukaryotes including vertebrates, insects, higher plants, and fungi. The delta-9 acyl-lipid desaturases are found in a wide...; Region: Delta9-FADS-like; cd03505 251221004743 Fatty acid desaturase; Region: FA_desaturase; pfam00487 251221004744 Di-iron ligands [ion binding]; other site 251221004745 The Delta9 Fatty Acid Desaturase (Delta9-FADS)-like CD includes the delta-9 and delta-11 acyl CoA desaturases found in various eukaryotes including vertebrates, insects, higher plants, and fungi. The delta-9 acyl-lipid desaturases are found in a wide...; Region: Delta9-FADS-like; cd03505 251221004746 Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane]; Region: Cfa; COG2230 251221004747 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 251221004748 S-adenosylmethionine binding site [chemical binding]; other site 251221004749 SAM dependent carboxyl methyltransferase; Region: Methyltransf_7; cl04109 251221004750 The Delta9 Fatty Acid Desaturase (Delta9-FADS)-like CD includes the delta-9 and delta-11 acyl CoA desaturases found in various eukaryotes including vertebrates, insects, higher plants, and fungi. The delta-9 acyl-lipid desaturases are found in a wide...; Region: Delta9-FADS-like; cd03505 251221004751 Fatty acid desaturase; Region: FA_desaturase; pfam00487 251221004752 Di-iron ligands [ion binding]; other site 251221004753 The Delta9 Fatty Acid Desaturase (Delta9-FADS)-like CD includes the delta-9 and delta-11 acyl CoA desaturases found in various eukaryotes including vertebrates, insects, higher plants, and fungi. The delta-9 acyl-lipid desaturases are found in a wide...; Region: Delta9-FADS-like; cd03505 251221004754 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 251221004755 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 251221004756 active site 251221004757 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 251221004758 Phosphopantetheine attachment site; Region: PP-binding; cl09936 251221004759 Predicted thioesterase involved in non-ribosomal peptide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: GrsT; COG3208 251221004760 Cytochrome P450; Region: p450; cl12078 251221004761 Phosphopantetheine attachment site; Region: PP-binding; cl09936 251221004762 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 251221004763 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 251221004764 active site 251221004765 Phosphopantetheine attachment site; Region: PP-binding; cl09936 251221004766 The Delta9 Fatty Acid Desaturase (Delta9-FADS)-like CD includes the delta-9 and delta-11 acyl CoA desaturases found in various eukaryotes including vertebrates, insects, higher plants, and fungi. The delta-9 acyl-lipid desaturases are found in a wide...; Region: Delta9-FADS-like; cd03505 251221004767 Di-iron ligands [ion binding]; other site 251221004768 Fatty acid desaturase; Region: FA_desaturase; pfam00487 251221004769 The Delta9 Fatty Acid Desaturase (Delta9-FADS)-like CD includes the delta-9 and delta-11 acyl CoA desaturases found in various eukaryotes including vertebrates, insects, higher plants, and fungi. The delta-9 acyl-lipid desaturases are found in a wide...; Region: Delta9-FADS-like; cd03505 251221004770 Di-iron ligands [ion binding]; other site 251221004771 The Delta9 Fatty Acid Desaturase (Delta9-FADS)-like CD includes the delta-9 and delta-11 acyl CoA desaturases found in various eukaryotes including vertebrates, insects, higher plants, and fungi. The delta-9 acyl-lipid desaturases are found in a wide...; Region: Delta9-FADS-like; cd03505 251221004772 acyl-CoA synthetase; Validated; Region: PRK05850 251221004773 Acyl-protein synthetase, LuxE; Region: LuxE; cl15695 251221004774 Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR2; cd08268 251221004775 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 251221004776 putative NAD(P) binding site [chemical binding]; other site 251221004777 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 251221004778 Acyl-protein synthetase, LuxE; Region: LuxE; cl15695 251221004779 Phosphopantetheinyl transferase [Coenzyme metabolism]; Region: Sfp; COG2091 251221004780 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; cl00500 251221004781 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiH; COG0654 251221004782 acyl-CoA synthetase; Validated; Region: PRK05850 251221004783 Acyl-protein synthetase, LuxE; Region: LuxE; cl15695 251221004784 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 251221004785 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 251221004786 active site 251221004787 Acyl transferase domain; Region: Acyl_transf_1; cl08282 251221004788 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 251221004789 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 2, complex (x); Region: KR_2_FAS_SDR_x; cd08955 251221004790 putative NADP binding site [chemical binding]; other site 251221004791 active site 251221004792 Phosphopantetheine attachment site; Region: PP-binding; cl09936 251221004793 Predicted thioesterase involved in non-ribosomal peptide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: GrsT; COG3208 251221004794 Phosphopantetheine attachment site; Region: PP-binding; cl09936 251221004795 2-Nitropropane dioxygenase (NPD)-like domain, associated with the (acyl-carrier-protein) S-malonyltransferase FabD. NPD is part of the nitroalkaneoxidizing enzyme family, that catalyzes oxidative denitrification of nitroalkanes to their corresponding...; Region: NPD_FabD; cd04742 251221004796 Dioxygenases related to 2-nitropropane dioxygenase [General function prediction only]; Region: COG2070 251221004797 FMN binding site [chemical binding]; other site 251221004798 substrate binding site [chemical binding]; other site 251221004799 putative catalytic residue [active] 251221004800 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 251221004801 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 251221004802 active site 251221004803 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 251221004804 active site 251221004805 Acyl transferase domain; Region: Acyl_transf_1; cl08282 251221004806 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 251221004807 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 251221004808 putative NADP binding site [chemical binding]; other site 251221004809 active site 251221004810 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 251221004811 polyketide-type polyunsaturated fatty acid synthase PfaA; Region: omega_3_PfaA; TIGR02813 251221004812 Acyl transferase domain; Region: Acyl_transf_1; cl08282 251221004813 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 251221004814 active site 251221004815 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 251221004816 N-terminal plug; other site 251221004817 ligand-binding site [chemical binding]; other site 251221004818 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 251221004819 active site 251221004820 metal binding site [ion binding]; metal-binding site 251221004821 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 251221004822 Flavin-binding monooxygenase-like; Region: FMO-like; pfam00743 251221004823 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 251221004824 Serine/threonine protein phosphatase 2A, regulatory subunit [Signal transduction mechanisms]; Region: CDC55; COG5170 251221004825 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 251221004826 structural tetrad; other site 251221004827 FOG: WD40 repeat [General function prediction only]; Region: COG2319 251221004828 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 251221004829 structural tetrad; other site 251221004830 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 251221004831 structural tetrad; other site 251221004832 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 251221004833 active site 251221004834 Domain of unknown function (DUF427); Region: DUF427; cl00998 251221004835 SERine Proteinase INhibitors (serpins), prokaryotic subgroup. Little information about specific functions is available for this subgroup, most likely they are inhibitory members of the serpin superfamily. In general, serpins exhibit conformational...; Region: bacterial_SERPIN; cd02049 251221004836 reactive center loop; other site 251221004837 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 251221004838 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 251221004839 Coenzyme A binding pocket [chemical binding]; other site 251221004840 Outer membrane cobalamin receptor protein [Coenzyme metabolism]; Region: BtuB; COG4206 251221004841 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 251221004842 N-terminal plug; other site 251221004843 ligand-binding site [chemical binding]; other site 251221004844 Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980 251221004845 dimer interface [polypeptide binding]; other site 251221004846 [2Fe-2S] cluster binding site [ion binding]; other site 251221004847 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 251221004848 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 251221004849 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 251221004850 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 251221004851 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 251221004852 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 251221004853 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 251221004854 N-terminal plug; other site 251221004855 ligand-binding site [chemical binding]; other site 251221004856 Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_2; cd03139 251221004857 conserved cys residue [active] 251221004858 Cytochrome c; Region: Cytochrom_C; cl11414 251221004859 Copper/zinc superoxide dismutase (SOD). superoxide dismutases catalyse the conversion of superoxide radicals to molecular oxygen. Three evolutionarily distinct families of SODs are known, of which the copper/zinc-binding family is one. Defects in the...; Region: Cu-Zn_Superoxide_Dismutase; cd00305 251221004860 E-class dimer interface [polypeptide binding]; other site 251221004861 P-class dimer interface [polypeptide binding]; other site 251221004862 active site 251221004863 Cu2+ binding site [ion binding]; other site 251221004864 Zn2+ binding site [ion binding]; other site 251221004865 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 251221004866 Ligand Binding Site [chemical binding]; other site 251221004867 phosphoenolpyruvate synthase; Validated; Region: PRK06464 251221004868 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 251221004869 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; cl01586 251221004870 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl09155 251221004871 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 251221004872 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 251221004873 Protein related to penicillin acylase [General function prediction only]; Region: COG2366 251221004874 The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467 251221004875 Penicillin G acylase (PGA) belongs to a family of beta-lactam acylases that includes cephalosporin acylase (CA) and aculeacin A acylase. PGA and CA are crucial for the production of backbone chemicals like 6-aminopenicillanic acid and...; Region: Ntn_PGA_like; cd03747 251221004876 active site 251221004877 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl12011 251221004878 septum formation inhibitor; Reviewed; Region: minC; PRK00513 251221004879 Septum formation inhibitor MinC, C-terminal domain; Region: MinC_C; pfam03775 251221004880 septum site-determining protein MinD; Region: minD_bact; TIGR01968 251221004881 Bacterial cell division requires the formation of a septum at mid-cell. The site is determined by the min operon products MinC, MinD and MinE. MinC is a nonspecific inhibitor of the septum protein FtsZ. MinE is the supressor of MinC. MinD plays a pivotal...; Region: MinD; cd02036 251221004882 Switch I; other site 251221004883 Switch II; other site 251221004884 Septum formation topological specificity factor MinE; Region: MinE; cl00538 251221004885 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 251221004886 Domain of unknown function DUF29; Region: DUF29; pfam01724 251221004887 pyruvate kinase; Validated; Region: PRK08187 251221004888 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl09155 251221004889 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl09155 251221004890 domain interfaces; other site 251221004891 active site 251221004892 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 251221004893 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 251221004894 Walker A/P-loop; other site 251221004895 ATP binding site [chemical binding]; other site 251221004896 Q-loop/lid; other site 251221004897 ABC transporter signature motif; other site 251221004898 Walker B; other site 251221004899 D-loop; other site 251221004900 H-loop/switch region; other site 251221004901 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 251221004902 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 251221004903 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 251221004904 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 251221004905 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 251221004906 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 251221004907 3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830 251221004908 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 251221004909 Transposase [DNA replication, recombination, and repair]; Region: COG5433 251221004910 Acyl-protein synthetase, LuxE; Region: LuxE; cl15695 251221004911 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 251221004912 Integrase core domain; Region: rve; cl01316 251221004913 Esterase/lipase [General function prediction only]; Region: COG1647 251221004914 YGGT family; Region: YGGT; cl00508 251221004915 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Provisional; Region: lpxD; PRK00892 251221004916 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase, LpxD; Region: LpxD; pfam04613 251221004917 UDP-3-O-acyl-glucosamine N-acyltransferase (LpxD): The enzyme catalyzes the transfer of 3-hydroxymyristic acid or 3-hydroxy-arachidic acid, depending on the organism, from the acyl carrier protein (ACP) to UDP-3-O-acyl-glucosamine to produce UDP-2; Region: LbH_LpxD; cd03352 251221004918 trimer interface [polypeptide binding]; other site 251221004919 active site 251221004920 UDP-GlcNAc binding site [chemical binding]; other site 251221004921 lipid binding site [chemical binding]; lipid-binding site 251221004922 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 251221004923 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 251221004924 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087 251221004925 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; cl08365 251221004926 Helix-turn-helix domains; Region: HTH; cl00088 251221004927 Helix-turn-helix domains; Region: HTH; cl00088 251221004928 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 251221004929 putative efflux pump membrane fusion protein; Provisional; Region: PRK03598 251221004930 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 251221004931 This family of ATP-binding proteins belongs to a multisubunit transporter involved in drug resistance (BcrA and DrrA), nodulation, lipid transport, and lantibiotic immunity. In bacteria and archaea, these transporters usually include an ATP-binding...; Region: ABC_DR_subfamily_A; cd03230 251221004932 Walker A/P-loop; other site 251221004933 ATP binding site [chemical binding]; other site 251221004934 Q-loop/lid; other site 251221004935 ABC transporter signature motif; other site 251221004936 Walker B; other site 251221004937 D-loop; other site 251221004938 H-loop/switch region; other site 251221004939 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 251221004940 The ABCA subfamily mediates the transport of a variety of lipid compounds. Mutations of members of ABCA subfamily are associated with human genetic diseases, such as, familial high-density lipoprotein (HDL) deficiency, neonatal surfactant deficiency; Region: ABC_subfamily_A; cd03263 251221004941 Walker A/P-loop; other site 251221004942 ATP binding site [chemical binding]; other site 251221004943 Q-loop/lid; other site 251221004944 ABC transporter signature motif; other site 251221004945 Walker B; other site 251221004946 D-loop; other site 251221004947 H-loop/switch region; other site 251221004948 ABC-2 type transporter; Region: ABC2_membrane; cl11417 251221004949 ABC-2 type transporter; Region: ABC2_membrane; cl11417 251221004950 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 251221004951 endonuclease III; Region: ENDO3c; smart00478 251221004952 minor groove reading motif; other site 251221004953 helix-hairpin-helix signature motif; other site 251221004954 substrate binding pocket [chemical binding]; other site 251221004955 active site 251221004956 Uncharacterized integral membrane protein (DUF2301); Region: DUF2301; cl02241 251221004957 ResB protein required for cytochrome c biosynthesis [Posttranslational modification, protein turnover, chaperones]; Region: ResB; cl09125 251221004958 ResB-like family; Region: ResB; pfam05140 251221004959 Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504 251221004960 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 251221004961 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 251221004962 Catalytic site [active] 251221004963 PIN domain of the VapC-like Sll0205 protein and homologs; Region: PIN_Sll0205; cd09872 251221004964 putative active site [active] 251221004965 Phd_YefM; Region: PhdYeFM; cl09153 251221004966 Protein of unknown function (DUF433); Region: DUF433; cl01030 251221004967 Helix-turn-helix domains; Region: HTH; cl00088 251221004968 Peptidase family M48; Region: Peptidase_M48; cl12018 251221004969 Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538 251221004970 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 251221004971 putative membrane fusion protein; Region: TIGR02828 251221004972 Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696 251221004973 FixH; Region: FixH; cl01254 251221004974 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 251221004975 Transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this domain superfamily was previously known as DUF156; Region: CsoR-like_DUF156; cd10148 251221004976 putative homotetramer interface [polypeptide binding]; other site 251221004977 putative homodimer interface [polypeptide binding]; other site 251221004978 putative allosteric switch controlling residues; other site 251221004979 putative metal binding site [ion binding]; other site 251221004980 putative homodimer-homodimer interface [polypeptide binding]; other site 251221004981 Type IV secretion-system coupling protein DNA-binding domain; Region: TrwB_AAD_bind; pfam10412 251221004982 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 251221004983 Walker A motif; other site 251221004984 ATP binding site [chemical binding]; other site 251221004985 Walker B motif; other site 251221004986 Putative transposase, YhgA-like; Region: Transposase_31; pfam04754 251221004987 hypothetical protein; Provisional; Region: PRK08317 251221004988 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 251221004989 S-adenosylmethionine binding site [chemical binding]; other site 251221004990 haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702 251221004991 Protein of unknown function (DUF3007); Region: DUF3007; pfam11460 251221004992 Adenosine specific kinase; Region: Adenosine_kin; cl00796 251221004993 ATP-utilizing enzymes of the PP-loop superfamily [General function prediction only]; Region: COG1606 251221004994 This is a subfamily of Adenine nucleotide alpha hydrolases superfamily. Adenine nucleotide alpha hydrolases superfamily includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which binds to Adenosine group. This subfamily; Region: Alpha_ANH_like_I; cd01990 251221004995 Ligand Binding Site [chemical binding]; other site 251221004996 Predicted metal-dependent phosphoesterases (PHP family) [General function prediction only]; Region: COG0613 251221004997 DNA polymerase alpha chain like domain; Region: POLIIIAc; smart00481 251221004998 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 251221004999 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 251221005000 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 251221005001 NAD(P) binding site [chemical binding]; other site 251221005002 active site 251221005003 DNA gyrase subunit A; Validated; Region: PRK05560 251221005004 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes in DNA...; Region: TOP4c; cd00187 251221005005 CAP-like domain; other site 251221005006 active site 251221005007 primary dimer interface [polypeptide binding]; other site 251221005008 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 251221005009 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 251221005010 TonB-dependent heme/hemoglobin receptor family protein; Region: TonB-hemin; TIGR01785 251221005011 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 251221005012 N-terminal plug; other site 251221005013 ligand-binding site [chemical binding]; other site 251221005014 Cobalt transport protein; Region: CbiQ; cl00463 251221005015 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 251221005016 Domain I of the ABC component of a cobalt transport family found in bacteria, archaea, and eukaryota. The transition metal cobalt is an essential component of many enzymes and must be transported into cells in appropriate amounts when needed. This ABC...; Region: ABC_cobalt_CbiO_domain1; cd03225 251221005017 Walker A/P-loop; other site 251221005018 ATP binding site [chemical binding]; other site 251221005019 Q-loop/lid; other site 251221005020 ABC transporter signature motif; other site 251221005021 Walker B; other site 251221005022 D-loop; other site 251221005023 H-loop/switch region; other site 251221005024 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 251221005025 cobalt transport protein ATP-binding subunit; Region: cbiO; TIGR01166 251221005026 Walker A/P-loop; other site 251221005027 ATP binding site [chemical binding]; other site 251221005028 Q-loop/lid; other site 251221005029 ABC transporter signature motif; other site 251221005030 Walker B; other site 251221005031 D-loop; other site 251221005032 H-loop/switch region; other site 251221005033 Leucine carboxyl methyltransferase; Region: LCM; cl01306 251221005034 putative high light inducible protein; Region: PHA02337 251221005035 Pyruvate decarboxylase and related thiamine pyrophosphate-requiring enzymes [Carbohydrate transport and metabolism / Coenzyme metabolism / General function prediction only]; Region: COG3961 251221005036 Pyrimidine (PYR) binding domain of pyruvate decarboxylase (PDC), indolepyruvate decarboxylase (IPDC) and related proteins; Region: TPP_PYR_PDC_IPDC_like; cd07038 251221005037 dimer interface [polypeptide binding]; other site 251221005038 PYR/PP interface [polypeptide binding]; other site 251221005039 TPP binding site [chemical binding]; other site 251221005040 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; cl00815 251221005041 Thiamine pyrophosphate (TPP) family, PDC_IPDC subfamily, TPP-binding module; composed of proteins similar to pyruvate decarboxylase (PDC) and indolepyruvate decarboxylase (IPDC). PDC, a key enzyme in alcoholic fermentation, catalyzes the conversion of...; Region: TPP_PDC_IPDC; cd02005 251221005042 TPP-binding site [chemical binding]; other site 251221005043 dimer interface [polypeptide binding]; other site 251221005044 Tryptophan 2,3-dioxygenase; Region: Trp_dioxygenase; cl03994 251221005045 FOG: CBS domain [General function prediction only]; Region: COG0517 251221005046 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_7; cd04620 251221005047 FOG: CBS domain [General function prediction only]; Region: COG0517 251221005048 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 251221005049 FOG: CBS domain [General function prediction only]; Region: COG0517 251221005050 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 251221005051 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 251221005052 dimer interface [polypeptide binding]; other site 251221005053 phosphorylation site [posttranslational modification] 251221005054 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 251221005055 ATP binding site [chemical binding]; other site 251221005056 Mg2+ binding site [ion binding]; other site 251221005057 G-X-G motif; other site 251221005058 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl15357 251221005059 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 251221005060 Ubiquitin-like proteins; Region: UBQ; cl00155 251221005061 threonine synthase; Validated; Region: PRK07591 251221005062 Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants; Region: Thr-synth_1; cd01563 251221005063 homodimer interface [polypeptide binding]; other site 251221005064 pyridoxal 5'-phosphate binding site [chemical binding]; other site 251221005065 catalytic residue [active] 251221005066 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 251221005067 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 251221005068 Coenzyme A binding pocket [chemical binding]; other site 251221005069 Clp protease ATP binding subunit; Region: clpC; CHL00095 251221005070 Clp amino terminal domain; Region: Clp_N; pfam02861 251221005071 Clp amino terminal domain; Region: Clp_N; pfam02861 251221005072 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 251221005073 Walker A motif; other site 251221005074 ATP binding site [chemical binding]; other site 251221005075 Walker B motif; other site 251221005076 arginine finger; other site 251221005077 UvrB/uvrC motif; Region: UVR; pfam02151 251221005078 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 251221005079 Walker A motif; other site 251221005080 ATP binding site [chemical binding]; other site 251221005081 Walker B motif; other site 251221005082 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; cl11083 251221005083 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 251221005084 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 251221005085 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 251221005086 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 251221005087 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 251221005088 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 251221005089 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 251221005090 Clp amino terminal domain; Region: Clp_N; pfam02861 251221005091 Clp amino terminal domain; Region: Clp_N; pfam02861 251221005092 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cl01898 251221005093 Uncharacterized conserved protein [Function unknown]; Region: COG2308 251221005094 Domain of unknown function (DUF404); Region: DUF404; pfam04169 251221005095 Domain of unknown function (DUF407); Region: DUF407; pfam04174 251221005096 Protein of unknown function (DUF3285); Region: DUF3285; pfam11688 251221005097 Part of the ABC transporter complex cysAWTP involved in sulfate import. Responsible for energy coupling to the transport system. The complex is composed of two ATP-binding proteins (cysA), two transmembrane proteins (cysT and cysW), and a...; Region: ABC_CysA_sulfate_importer; cd03296 251221005098 sulfate ABC transporter, ATP-binding protein; Region: 3a0106s01; TIGR00968 251221005099 Walker A/P-loop; other site 251221005100 ATP binding site [chemical binding]; other site 251221005101 Q-loop/lid; other site 251221005102 ABC transporter signature motif; other site 251221005103 Walker B; other site 251221005104 D-loop; other site 251221005105 H-loop/switch region; other site 251221005106 TOBE domain; Region: TOBE_2; cl01440 251221005107 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 251221005108 sulfate ABC transporter, permease protein CysT; Region: permease_CysT; TIGR02139 251221005109 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 251221005110 dimer interface [polypeptide binding]; other site 251221005111 conserved gate region; other site 251221005112 putative PBP binding loops; other site 251221005113 ABC-ATPase subunit interface; other site 251221005114 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 251221005115 dimer interface [polypeptide binding]; other site 251221005116 conserved gate region; other site 251221005117 putative PBP binding loops; other site 251221005118 ABC-ATPase subunit interface; other site 251221005119 Protein of unknown function (DUF2490); Region: DUF2490; pfam10677 251221005120 Ribbon-helix-helix protein, copG family; Region: RHH_1; cl15375 251221005121 Beta-propeller repeat; Region: SBBP; pfam06739 251221005122 Beta-propeller repeat; Region: SBBP; pfam06739 251221005123 Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as Transcription factor ImmunoGlobin (TIG) domains. They are present in intracellular transcription factors, cell surface receptors (such as plexins and scatter factor...; Region: IPT; cd00102 251221005124 ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK14457 251221005125 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 251221005126 FeS/SAM binding site; other site 251221005127 CO2 hydration protein (ChpXY); Region: ChpXY; cl10905 251221005128 NAD(P)H-quinone oxidoreductase subunit D4; Validated; Region: PRK06473 251221005129 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; cl14187 251221005130 NAD(P)H-quinone oxidoreductase subunit F; Validated; Region: PRK07390 251221005131 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; cl14187 251221005132 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 251221005133 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl15260 251221005134 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 251221005135 dimer interface [polypeptide binding]; other site 251221005136 conserved gate region; other site 251221005137 putative PBP binding loops; other site 251221005138 ABC-ATPase subunit interface; other site 251221005139 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeC; cd03378 251221005140 active site clefts [active] 251221005141 zinc binding site [ion binding]; other site 251221005142 dimer interface [polypeptide binding]; other site 251221005143 NrtD and SsuB are the ATP-binding subunits of the bacterial ABC-type nitrate and sulfonate transport systems, respectively. ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars; Region: ABC_NrtD_SsuB_transporters; cd03293 251221005144 nitrate transport ATP-binding subunits C and D; Region: ntrCD; TIGR01184 251221005145 Walker A/P-loop; other site 251221005146 ATP binding site [chemical binding]; other site 251221005147 Q-loop/lid; other site 251221005148 ABC transporter signature motif; other site 251221005149 Walker B; other site 251221005150 D-loop; other site 251221005151 H-loop/switch region; other site 251221005152 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 251221005153 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl15260 251221005154 NrtD and SsuB are the ATP-binding subunits of the bacterial ABC-type nitrate and sulfonate transport systems, respectively. ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars; Region: ABC_NrtD_SsuB_transporters; cd03293 251221005155 nitrate transport ATP-binding subunits C and D; Region: ntrCD; TIGR01184 251221005156 Walker A/P-loop; other site 251221005157 ATP binding site [chemical binding]; other site 251221005158 Q-loop/lid; other site 251221005159 ABC transporter signature motif; other site 251221005160 Walker B; other site 251221005161 D-loop; other site 251221005162 H-loop/switch region; other site 251221005163 Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577 251221005164 Carbon dioxide concentrating mechanism (CcmK); Bacterial Micro-Compartment (BCM) domain; Region: BMC_CcmK; cd07057 251221005165 Hexamer interface [polypeptide binding]; other site 251221005166 Hexagonal pore residue; other site 251221005167 Carbon dioxide concentrating mechanism (CcmK); Bacterial Micro-Compartment (BCM) domain; Region: BMC_CcmK; cd07057 251221005168 Hexamer interface [polypeptide binding]; other site 251221005169 Hexagonal pore residue; other site 251221005170 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 251221005171 putative trimer interface [polypeptide binding]; other site 251221005172 putative CoA binding site [chemical binding]; other site 251221005173 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 251221005174 Gamma carbonic anhydrases (CA): Carbonic anhydrases are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism, involving the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide, followed...; Region: LbH_gamma_CA; cd00710 251221005175 trimer interface [polypeptide binding]; other site 251221005176 active site 251221005177 Ribulose bisphosphate carboxylase/oxygenase (Rubisco), small subunit and related proteins. Rubisco is a bifunctional enzyme catalyzes the initial steps of two opposing metabolic pathways: photosynthetic carbon fixation and the competing process of...; Region: RuBisCO_small_like; cd00307 251221005178 putative multimerization interface [polypeptide binding]; other site 251221005179 Ribulose bisphosphate carboxylase/oxygenase (Rubisco), small subunit and related proteins. Rubisco is a bifunctional enzyme catalyzes the initial steps of two opposing metabolic pathways: photosynthetic carbon fixation and the competing process of...; Region: RuBisCO_small_like; cd00307 251221005180 putative multimerization interface [polypeptide binding]; other site 251221005181 Ribulose bisphosphate carboxylase/oxygenase (Rubisco), small subunit and related proteins. Rubisco is a bifunctional enzyme catalyzes the initial steps of two opposing metabolic pathways: photosynthetic carbon fixation and the competing process of...; Region: RuBisCO_small_like; cd00307 251221005182 putative multimerization interface [polypeptide binding]; other site 251221005183 Ribulose bisphosphate carboxylase/oxygenase (Rubisco), small subunit and related proteins. Rubisco is a bifunctional enzyme catalyzes the initial steps of two opposing metabolic pathways: photosynthetic carbon fixation and the competing process of...; Region: RuBisCO_small_like; cd00307 251221005184 putative multimerization interface [polypeptide binding]; other site 251221005185 Ethanolamine utilisation protein and carboxysome structural protein domain family; Region: EutN_CcmL; cd01614 251221005186 Hexamer/Pentamer interface [polypeptide binding]; other site 251221005187 central pore; other site 251221005188 Carbon dioxide concentrating mechanism (CcmK); Bacterial Micro-Compartment (BCM) domain; Region: BMC_CcmK; cd07057 251221005189 Hexamer interface [polypeptide binding]; other site 251221005190 Hexagonal pore residue; other site 251221005191 Carbon dioxide concentrating mechanism (CcmK); Bacterial Micro-Compartment (BCM) domain; Region: BMC_CcmK; cd07057 251221005192 Hexamer interface [polypeptide binding]; other site 251221005193 Hexagonal pore residue; other site 251221005194 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149 251221005195 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 251221005196 N-methylhydantoinase A/acetone carboxylase, beta subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuA; COG0145 251221005197 Hydantoinase/oxoprolinase N-terminal region; Region: Hydant_A_N; pfam05378 251221005198 Hydantoinase/oxoprolinase; Region: Hydantoinase_A; cl00668 251221005199 Phytase; Region: Phytase; pfam02333 251221005200 FO synthase subunit 1; Reviewed; Region: cofG; PRK06245 251221005201 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 251221005202 FeS/SAM binding site; other site 251221005203 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 251221005204 active site 251221005205 ATP binding site [chemical binding]; other site 251221005206 substrate binding site [chemical binding]; other site 251221005207 activation loop (A-loop); other site 251221005208 Tryptophan-rich protein (DUF2389); Region: DUF2389; cl09726 251221005209 Iron-sulphur cluster biosynthesis; Region: Fe-S_biosyn; cl00400 251221005210 periplasmic serine pepetdase DegS; Region: protease_degS; TIGR02038 251221005211 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149 251221005212 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 251221005213 protein binding site [polypeptide binding]; other site 251221005214 Peroxiredoxin (PRX)-like 1 family; hypothetical proteins that show sequence similarity to PRXs. Members of this group contain a conserved cysteine that aligns to the first cysteine in the CXXC motif of TRX. This does not correspond to the peroxidatic...; Region: PRX_like1; cd02969 251221005215 putative catalytic residue [active] 251221005216 recombination factor protein RarA/unknown domain fusion protein; Reviewed; Region: PRK13341 251221005217 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 251221005218 Walker A motif; other site 251221005219 ATP binding site [chemical binding]; other site 251221005220 Walker B motif; other site 251221005221 arginine finger; other site 251221005222 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 251221005223 Cupin domain; Region: Cupin_2; cl09118 251221005224 Vitamin K epoxide reductase family; Region: VKOR; cl01729 251221005225 5'-adenylylsulfate reductase; Region: PLN02309 251221005226 Protein Disulfide Isomerase (PDIa) family, redox active TRX domains; composed of eukaryotic proteins involved in oxidative protein folding in the endoplasmic reticulum (ER) by acting as catalysts and folding assistants. Members of this family include PDI...; Region: PDI_a_family; cd02961 251221005227 catalytic residues [active] 251221005228 phosphoribosylformylglycinamidine synthase II; Provisional; Region: PRK01213 251221005229 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 251221005230 dimerization interface [polypeptide binding]; other site 251221005231 ATP binding site [chemical binding]; other site 251221005232 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 251221005233 dimerization interface [polypeptide binding]; other site 251221005234 ATP binding site [chemical binding]; other site 251221005235 amidophosphoribosyltransferase; Provisional; Region: PRK07349 251221005236 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 251221005237 active site 251221005238 tetramer interface [polypeptide binding]; other site 251221005239 Phosphoribosyl transferase domain; Region: Pribosyltran; cl00309 251221005240 (p)ppGpp synthetase, RelA/SpoT family; Region: spoT_relA; TIGR00691 251221005241 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 251221005242 N-terminal plug; other site 251221005243 Outer membrane cobalamin receptor protein [Coenzyme metabolism]; Region: BtuB; COG4206 251221005244 ligand-binding site [chemical binding]; other site 251221005245 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 251221005246 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 251221005247 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 251221005248 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 251221005249 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 251221005250 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 251221005251 enolase; Provisional; Region: eno; PRK00077 251221005252 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 251221005253 dimer interface [polypeptide binding]; other site 251221005254 metal binding site [ion binding]; metal-binding site 251221005255 substrate binding pocket [chemical binding]; other site 251221005256 phosphoribulokinase; Provisional; Region: PRK07429 251221005257 Phosphoribulokinase (PRK) is an enzyme involved in the Benson-Calvin cycle in chloroplasts or photosynthetic prokaryotes. This enzyme catalyzes the phosphorylation of D-ribulose 5-phosphate to form D-ribulose 1, 5-biphosphate, using ATP and NADPH...; Region: PRK; cd02026 251221005258 active site 251221005259 Putative catalytic NodB homology domain of PgaB, IcaB, and similar proteins which consist of a deformed (beta/alpha)8 barrel fold with 5- or 6-strands; Region: CE4_NodB_like_5s_6s; cd10918 251221005260 putative active site [active] 251221005261 putative metal binding site [ion binding]; other site 251221005262 Protein of unknown function (DUF2288); Region: DUF2288; cl02399 251221005263 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 251221005264 FOG: Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3385 251221005265 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 251221005266 Catalytic domain of Protein Kinases; Region: PKc; cd00180 251221005267 active site 251221005268 ATP binding site [chemical binding]; other site 251221005269 substrate binding site [chemical binding]; other site 251221005270 activation loop (A-loop); other site 251221005271 Transposase domain (DUF772); Region: DUF772; cl15789 251221005272 putative transposase OrfB; Reviewed; Region: PHA02517 251221005273 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 251221005274 Protein of unknown function (DUF1778); Region: DUF1778; cl01845 251221005275 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 251221005276 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 251221005277 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 251221005278 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 251221005279 CoA-binding site [chemical binding]; other site 251221005280 ATP-binding [chemical binding]; other site 251221005281 Protein of unknown function (DUF1997); Region: DUF1997; pfam09366 251221005282 ribosomal protein L11 methyltransferase; Reviewed; Region: prmA; PRK00517 251221005283 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 251221005284 S-adenosylmethionine binding site [chemical binding]; other site 251221005285 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 251221005286 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 251221005287 Cupin domain; Region: Cupin_2; cl09118 251221005288 D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK13581 251221005289 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 251221005290 C-terminal ACT (regulatory) domain of D-3-phosphoglycerate dehydrogenase (3PGDH); Region: ACT_3PGDH-xct; cd04902 251221005291 putative L-serine binding site [chemical binding]; other site 251221005292 RNA methyltransferase, TrmH family, group 1; Region: rRNA_methyl_1; TIGR00050 251221005293 SpoU rRNA Methylase family; Region: SpoU_methylase; cl00362 251221005294 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 251221005295 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 251221005296 peptide binding site [polypeptide binding]; other site 251221005297 Uncharacterized conserved protein [Function unknown]; Region: COG5464 251221005298 Protein of unknown function (DUF2887); Region: DUF2887; pfam11103 251221005299 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_19; cd07262 251221005300 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 251221005301 Highly conserved protein containing a thioredoxin domain [Posttranslational modification, protein turnover, chaperones]; Region: COG1331 251221005302 TRX domain, SSP411 protein family; members of this family are highly conserved proteins present in eukaryotes, bacteria and archaea, about 600-800 amino acids in length, which contain a TRX domain with a redox active CXXC motif. The human/rat protein; Region: SSP411; cd02955 251221005303 catalytic residues [active] 251221005304 AGE domain; N-acyl-D-glucosamine 2-epimerase domain; Responsible for intermediate epimerization during biosynthesis of N-acetylneuraminic acid. Catalytic mechanism is believed to be via nucleotide elimination and readdition and is ATP modulated. AGE is...; Region: AGE; cl00183 251221005305 Acyl transferase domain; Region: Acyl_transf_1; cl08282 251221005306 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 251221005307 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4222 251221005308 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 251221005309 ACT_MalLac-Enz CD includes the N-terminal ACT domain of putative NAD-dependent malic enzyme 1, Bacillus subtilis YqkI and related domains; Region: ACT_MalLac-Enz; cd04887 251221005310 Malic enzyme, N-terminal domain; Region: malic; pfam00390 251221005311 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 251221005312 putative NAD(P) binding site [chemical binding]; other site 251221005313 Fasciclin domain; Region: Fasciclin; cl02663 251221005314 Protein of unknown function (DUF2393); Region: DUF2393; cl09840 251221005315 Putative integral membrane protein (DUF2391); Region: DUF2391; cl01935 251221005316 Polyphosphate kinase 2 (PPK2); Region: PPK2; cl11971 251221005317 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 251221005318 NAD(P) binding site [chemical binding]; other site 251221005319 active site 251221005320 peroxiredoxin; Region: AhpC; TIGR03137 251221005321 ribulose-1,5-bisphosphate carboxylase/oxygenase large subunit; Region: rbcL; CHL00040 251221005322 Ribulose bisphosphate carboxylase large chain, Form I; Region: RuBisCO_large_I; cd08212 251221005323 homodimer interface [polypeptide binding]; other site 251221005324 active site 251221005325 heterodimer interface [polypeptide binding]; other site 251221005326 catalytic residue [active] 251221005327 metal binding site [ion binding]; metal-binding site 251221005328 RbcX protein; Region: RcbX; pfam02341 251221005329 Ribulose bisphosphate carboxylase/oxygenase (Rubisco), small subunit. Rubisco is a bifunctional enzyme catalyzes the initial steps of two opposing metabolic pathways: photosynthetic carbon fixation and the competing process of photorespiration. Rubisco...; Region: RuBisCO_small; cd03527 251221005330 multimerization interface [polypeptide binding]; other site 251221005331 Uncharacterized conserved protein [Function unknown]; Region: COG1656; cl09136 251221005332 Protein of unknown function (DUF433); Region: DUF433; cl01030 251221005333 Heme-copper oxidase subunit III. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which couple the reduction of molecular oxygen to water to, proton pumping across the membrane. The...; Region: Heme_Cu_Oxidase_III_like; cd00386 251221005334 Subunit I/III interface [polypeptide binding]; other site 251221005335 cytochrome c oxidase subunit I; Validated; Region: COX1; MTH00007 251221005336 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 251221005337 D-pathway; other site 251221005338 Putative ubiquinol binding site [chemical binding]; other site 251221005339 Low-spin heme (heme b) binding site [chemical binding]; other site 251221005340 Putative water exit pathway; other site 251221005341 Binuclear center (heme o3/CuB) [ion binding]; other site 251221005342 K-pathway; other site 251221005343 Putative proton exit pathway; other site 251221005344 Heme/copper-type cytochrome/quinol oxidases, subunit 2 [Energy production and conversion]; Region: CyoA; COG1622 251221005345 Cytochrome C oxidase subunit II, transmembrane domain; Region: COX2_TM; pfam02790 251221005346 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; cl11412 251221005347 Cytochrome oxidase assembly protein; Region: COX15-CtaA; pfam02628 251221005348 UbiA prenyltransferase family; Region: UbiA; cl00337 251221005349 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 251221005350 daunorubicin resistance ABC transporter ATP-binding subunit; Region: drrA; TIGR01188 251221005351 Walker A/P-loop; other site 251221005352 ATP binding site [chemical binding]; other site 251221005353 Q-loop/lid; other site 251221005354 ABC transporter signature motif; other site 251221005355 Walker B; other site 251221005356 D-loop; other site 251221005357 H-loop/switch region; other site 251221005358 ABC-2 type transporter; Region: ABC2_membrane; cl11417 251221005359 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313 251221005360 Copper/zinc superoxide dismutase (SOD). superoxide dismutases catalyse the conversion of superoxide radicals to molecular oxygen. Three evolutionarily distinct families of SODs are known, of which the copper/zinc-binding family is one. Defects in the...; Region: Cu-Zn_Superoxide_Dismutase; cl00891 251221005361 E-class dimer interface [polypeptide binding]; other site 251221005362 P-class dimer interface [polypeptide binding]; other site 251221005363 active site 251221005364 Cu2+ binding site [ion binding]; other site 251221005365 Zn2+ binding site [ion binding]; other site 251221005366 Glyoxal oxidase N-terminus; Region: Glyoxal_oxid_N; pfam07250 251221005367 C-terminal Early set domain associated with the catalytic domain of galactose oxidase; Region: E_set_GO_C; cd02851 251221005368 Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645 251221005369 trimer interface [polypeptide binding]; other site 251221005370 putative metal binding site [ion binding]; other site 251221005371 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 251221005372 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 251221005373 NfeD-like C-terminal, partner-binding; Region: NfeD; cl00686 251221005374 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 251221005375 molybdopterin cofactor binding site; other site 251221005376 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 251221005377 Helix-turn-helix domains; Region: HTH; cl00088 251221005378 Double zinc ribbon; Region: DZR; pfam12773 251221005379 Acyl-[acyl carrier protein]; Region: LpxA; COG1043 251221005380 Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647 251221005381 trimer interface [polypeptide binding]; other site 251221005382 active site 251221005383 substrate binding site [chemical binding]; other site 251221005384 CoA binding site [chemical binding]; other site 251221005385 GAF domain; Region: GAF; cl00853 251221005386 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 251221005387 UDP-glucuronate decarboxylase (UGD) and related proteins, extended (e) SDRs; Region: UGD_SDR_e; cd05230 251221005388 NAD binding site [chemical binding]; other site 251221005389 putative substrate binding site 2 [chemical binding]; other site 251221005390 putative substrate binding site 1 [chemical binding]; other site 251221005391 active site 251221005392 Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004 251221005393 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 251221005394 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 251221005395 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 251221005396 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 251221005397 PAS fold; Region: PAS_3; pfam08447 251221005398 putative active site [active] 251221005399 heme pocket [chemical binding]; other site 251221005400 OpgC protein; Region: OpgC_C; cl00792 251221005401 Acyltransferase family; Region: Acyl_transf_3; pfam01757 251221005402 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 251221005403 putative trimer interface [polypeptide binding]; other site 251221005404 putative CoA binding site [chemical binding]; other site 251221005405 Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647 251221005406 trimer interface [polypeptide binding]; other site 251221005407 active site 251221005408 substrate binding site [chemical binding]; other site 251221005409 CoA binding site [chemical binding]; other site 251221005410 GAF domain; Region: GAF; cl00853 251221005411 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 251221005412 GlcNAc-PI de-N-acetylase; Region: PIG-L; cl00929 251221005413 G1P_cytidylyltransferase catalyzes the production of CDP-D-Glucose; Region: G1P_cytidylyltransferase; cd02524 251221005414 substrate binding site; other site 251221005415 OpgC protein; Region: OpgC_C; cl00792 251221005416 Acyltransferase family; Region: Acyl_transf_3; pfam01757 251221005417 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3415 251221005418 Bacterial sugar transferase; Region: Bac_transf; cl00939 251221005419 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 251221005420 active site 251221005421 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 251221005422 active site 251221005423 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 251221005424 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 251221005425 active site 251221005426 Sulfotransferase domain; Region: Sulfotransfer_1; pfam00685 251221005427 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 251221005428 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_6; cd04955 251221005429 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 251221005430 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 251221005431 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 251221005432 MsbA is an essential ABC transporter, closely related to eukaryotic MDR proteins. ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars, ions, peptides, and more complex organic...; Region: ABCC_MsbA; cd03251 251221005433 Walker A/P-loop; other site 251221005434 ATP binding site [chemical binding]; other site 251221005435 Q-loop/lid; other site 251221005436 ABC transporter signature motif; other site 251221005437 Walker B; other site 251221005438 D-loop; other site 251221005439 H-loop/switch region; other site 251221005440 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: GT1_like_7; cd05844 251221005441 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 251221005442 putative ADP-binding pocket [chemical binding]; other site 251221005443 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 251221005444 Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307 251221005445 O-Antigen ligase; Region: Wzy_C; cl04850 251221005446 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 251221005447 NTP_transferases catalyze the transfer of nucleotides onto phosphosugars; Region: NTP_transferase; cd04181 251221005448 active site 251221005449 Substrate binding site; other site 251221005450 Mg++ binding site; other site 251221005451 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 251221005452 Periplasmic protein involved in polysaccharide export, contains SLBB domain of b-grasp fold [Cell wall/membrane/envelope biogenesis]; Region: Wza; COG1596 251221005453 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 251221005454 Periplasmic protein involved in polysaccharide export, contains SLBB domain of b-grasp fold [Cell wall/membrane/envelope biogenesis]; Region: Wza; COG1596 251221005455 SLBB domain; Region: SLBB; pfam10531 251221005456 Uncharacterized protein involved in exopolysaccharide biosynthesis [Cell envelope biogenesis, outer membrane]; Region: GumC; COG3206 251221005457 Chain length determinant protein; Region: Wzz; cl01623 251221005458 capsular exopolysaccharide family; Region: eps_fam; TIGR01007 251221005459 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 251221005460 Nucleotide binding site [chemical binding]; other site 251221005461 DTAP/Switch II; other site 251221005462 Predicted homoserine dehydrogenase [Amino acid transport and metabolism]; Region: COG4091 251221005463 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 251221005464 SAF domain; Region: SAF; cl00555 251221005465 Predicted homoserine dehydrogenase [Amino acid transport and metabolism]; Region: COG4091 251221005466 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 251221005467 SAF domain; Region: SAF; cl00555 251221005468 Cupin domain; Region: Cupin_2; cl09118 251221005469 extended (e) SDRs; Region: SDR_e; cd08946 251221005470 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 251221005471 NAD(P) binding site [chemical binding]; other site 251221005472 active site 251221005473 substrate binding site [chemical binding]; other site 251221005474 Predicted dehydrogenase [General function prediction only]; Region: COG0579 251221005475 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 251221005476 G1P_cytidylyltransferase catalyzes the production of CDP-D-Glucose; Region: G1P_cytidylyltransferase; cd02524 251221005477 substrate binding site; other site 251221005478 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 251221005479 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 251221005480 active site 251221005481 phosphorylation site [posttranslational modification] 251221005482 intermolecular recognition site; other site 251221005483 dimerization interface [polypeptide binding]; other site 251221005484 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 251221005485 DNA binding residues [nucleotide binding] 251221005486 dimerization interface [polypeptide binding]; other site 251221005487 CrcB-like protein; Region: CRCB; cl09114 251221005488 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 251221005489 ligand binding site [chemical binding]; other site 251221005490 flexible hinge region; other site 251221005491 sensory histidine kinase AtoS; Provisional; Region: PRK11360 251221005492 Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972 251221005493 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 251221005494 ATP binding site [chemical binding]; other site 251221005495 Mg2+ binding site [ion binding]; other site 251221005496 G-X-G motif; other site 251221005497 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 251221005498 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 251221005499 glutaminase active site [active] 251221005500 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 251221005501 dimer interface [polypeptide binding]; other site 251221005502 active site 251221005503 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 251221005504 dimer interface [polypeptide binding]; other site 251221005505 active site 251221005506 Protein of unknown function (DUF528); Region: DUF528; cl01123 251221005507 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 251221005508 Coenzyme A binding pocket [chemical binding]; other site 251221005509 serine decarboxylase; Region: PLN02263 251221005510 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 251221005511 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 251221005512 catalytic residue [active] 251221005513 Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872 251221005514 Glutamate decarboxylase and related PLP-dependent proteins [Amino acid transport and metabolism]; Region: GadB; COG0076 251221005515 DOPA decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to DOPA/tyrosine decarboxylase (DDC), histidine decarboxylase (HDC), and...; Region: DOPA_deC_like; cd06450 251221005516 pyridoxal 5'-phosphate binding site [chemical binding]; other site 251221005517 catalytic residue [active] 251221005518 diaminobutyrate--2-oxoglutarate aminotransferase; Provisional; Region: PRK06938 251221005519 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 251221005520 inhibitor-cofactor binding pocket; inhibition site 251221005521 pyridoxal 5'-phosphate binding site [chemical binding]; other site 251221005522 catalytic residue [active] 251221005523 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 251221005524 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 251221005525 binding surface 251221005526 TPR motif; other site 251221005527 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 251221005528 Anaphase-promoting complex, cyclosome, subunit 3; Region: Apc3; pfam12895 251221005529 TPR motif; other site 251221005530 binding surface 251221005531 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 251221005532 binding surface 251221005533 TPR motif; other site 251221005534 Anaphase-promoting complex, cyclosome, subunit 3; Region: Apc3; pfam12895 251221005535 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 251221005536 binding surface 251221005537 TPR motif; other site 251221005538 Anaphase-promoting complex, cyclosome, subunit 3; Region: Apc3; pfam12895 251221005539 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 251221005540 CHAT domain; Region: CHAT; cl02083 251221005541 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 251221005542 active site 251221005543 catalytic residues [active] 251221005544 metal binding site [ion binding]; metal-binding site 251221005545 rod shape-determining protein MreB; Provisional; Region: PRK13930 251221005546 Actin; An ubiquitous protein involved in the formation of filaments that are a major component of the cytoskeleton. Interaction with myosin provides the basis of muscular contraction and many aspects of cell motility. Each actin protomer binds one...; Region: ACTIN; cl11528 251221005547 ATP binding site [chemical binding]; other site 251221005548 profilin binding site; other site 251221005549 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 251221005550 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 251221005551 putative inner membrane protein translocase component YidC; Provisional; Region: PRK02654 251221005552 60Kd inner membrane protein; Region: 60KD_IMP; cl00489 251221005553 60Kd inner membrane protein; Region: 60KD_IMP; cl00489 251221005554 jag_K homology RNA-binding domain. The KH domain is found in proteins homologous to the Bacillus subtilis protein Jag, which is associated with SpoIIIJ and is necessary for the third stage of sporulation. The KH motif is a beta-alpha-alpha-beta-beta...; Region: jag_KH; cd02414 251221005555 G-X-X-G motif; other site 251221005556 R3H domain found in proteins homologous to Bacillus subtilus Jag, which is associated with SpoIIIJ. SpoIIIJ is necessary for the third stage of sporulation. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine...; Region: R3H_jag; cd02644 251221005557 RxxxH motif; other site 251221005558 Uncharacterized ACR, COG1399; Region: DUF177; cl00616 251221005559 FOG: HEAT repeat [Energy production and conversion]; Region: COG1413 251221005560 PBS lyase HEAT-like repeat; Region: HEAT_PBS; cl15388 251221005561 Predicted Fe-S oxidoreductase [General function prediction only]; Region: COG1242 251221005562 Photosystem I reaction centre subunit XI; Region: PsaL; cl03651 251221005563 YjeF-related protein N-terminus; Region: YjeF_N; cl00318 251221005564 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 251221005565 putative substrate binding site [chemical binding]; other site 251221005566 putative ATP binding site [chemical binding]; other site 251221005567 ATP-dependent Clp protease adaptor protein ClpS; Region: ClpS; cl00933 251221005568 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 251221005569 putative acyl-acceptor binding pocket; other site 251221005570 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 251221005571 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 251221005572 Caspase, interleukin-1 beta converting enzyme (ICE) homologues; Cysteine-dependent aspartate-directed proteases that mediate programmed cell death (apoptosis). Caspases are synthesized as inactive zymogens and activated by proteolysis of the peptide...; Region: CASc; cl00042 251221005573 FOG: WD40 repeat [General function prediction only]; Region: COG2319 251221005574 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 251221005575 structural tetrad; other site 251221005576 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 251221005577 structural tetrad; other site 251221005578 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 251221005579 structural tetrad; other site 251221005580 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 251221005581 Radical SAM superfamily; Region: Radical_SAM; pfam04055 251221005582 FeS/SAM binding site; other site 251221005583 radical SAM additional 4Fe4S-binding domain; Region: rSAM_more_4Fe4S; cl14869 251221005584 Domain of unknown function (DUF427); Region: DUF427; cl00998 251221005585 ASPIC and UnbV; Region: UnbV_ASPIC; pfam07593 251221005586 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 251221005587 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 251221005588 Walker A/P-loop; other site 251221005589 ATP binding site [chemical binding]; other site 251221005590 Q-loop/lid; other site 251221005591 ABC transporter signature motif; other site 251221005592 Walker B; other site 251221005593 D-loop; other site 251221005594 H-loop/switch region; other site 251221005595 Transposase [DNA replication, recombination, and repair]; Region: COG5421 251221005596 Transposase [DNA replication, recombination, and repair]; Region: COG5421 251221005597 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447 251221005598 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 251221005599 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 251221005600 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 251221005601 TPR motif; other site 251221005602 binding surface 251221005603 p-Aminobenzoyl-glutamate transporter family; Region: ydaH; TIGR00819 251221005604 C4-dicarboxylate anaerobic carrier; Region: DcuC; cl15356 251221005605 Response regulator receiver domain; Region: Response_reg; pfam00072 251221005606 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 251221005607 active site 251221005608 phosphorylation site [posttranslational modification] 251221005609 intermolecular recognition site; other site 251221005610 dimerization interface [polypeptide binding]; other site 251221005611 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 251221005612 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 251221005613 dimer interface [polypeptide binding]; other site 251221005614 phosphorylation site [posttranslational modification] 251221005615 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 251221005616 ATP binding site [chemical binding]; other site 251221005617 Mg2+ binding site [ion binding]; other site 251221005618 G-X-G motif; other site 251221005619 Arginate lyase and other MDR family members; Region: AL_MDR; cd08252 251221005620 zinc-binding alcohol dehydrogenase family protein; Region: adh_fam_1; TIGR02817 251221005621 putative NAD(P) binding site [chemical binding]; other site 251221005622 dimer interface [polypeptide binding]; other site 251221005623 Glucose/sorbosone dehydrogenases [Carbohydrate transport and metabolism]; Region: COG2133 251221005624 Glucose / Sorbosone dehydrogenase; Region: GSDH; pfam07995 251221005625 amino acid/peptide transporter (Peptide:H+ symporter), bacterial; Region: yjdL_sub1_fam; TIGR00924 251221005626 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 251221005627 putative substrate translocation pore; other site 251221005628 CsbD-like; Region: CsbD; cl01888 251221005629 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 251221005630 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 251221005631 Walker A/P-loop; other site 251221005632 ATP binding site [chemical binding]; other site 251221005633 Q-loop/lid; other site 251221005634 ABC transporter signature motif; other site 251221005635 Walker B; other site 251221005636 D-loop; other site 251221005637 H-loop/switch region; other site 251221005638 Superfamily II DNA/RNA helicases, SNF2 family [Transcription / DNA replication, recombination, and repair]; Region: HepA; COG0553 251221005639 SNF2 Helicase protein; Region: DUF3670; pfam12419 251221005640 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 251221005641 ATP binding site [chemical binding]; other site 251221005642 putative Mg++ binding site [ion binding]; other site 251221005643 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 251221005644 nucleotide binding region [chemical binding]; other site 251221005645 ATP-binding site [chemical binding]; other site 251221005646 SWIM zinc finger; Region: SWIM; cl15408 251221005647 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cl14780 251221005648 active site 251221005649 Orthopoxvirus protein of unknown function (DUF830); Region: DUF830; cl13998 251221005650 heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082 251221005651 HrcA protein C terminal domain; Region: HrcA; pfam01628 251221005652 Response regulator receiver domain; Region: Response_reg; pfam00072 251221005653 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 251221005654 active site 251221005655 phosphorylation site [posttranslational modification] 251221005656 intermolecular recognition site; other site 251221005657 dimerization interface [polypeptide binding]; other site 251221005658 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 251221005659 dimer interface [polypeptide binding]; other site 251221005660 phosphorylation site [posttranslational modification] 251221005661 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 251221005662 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 251221005663 active site 251221005664 phosphorylation site [posttranslational modification] 251221005665 intermolecular recognition site; other site 251221005666 dimerization interface [polypeptide binding]; other site 251221005667 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 251221005668 DNA binding site [nucleotide binding] 251221005669 Glutamate-cysteine ligase family 2(GCS2); Region: GCS2; cl00954 251221005670 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; cl11412 251221005671 Berberine and berberine like; Region: BBE; pfam08031 251221005672 NmrA (a transcriptional regulator) and HSCARG (an NADPH sensor) like proteins, atypical (a) SDRs; Region: NmrA_like_SDR_a; cd05251 251221005673 NmrA-like family; Region: NmrA; pfam05368 251221005674 NADP binding site [chemical binding]; other site 251221005675 active site 251221005676 regulatory binding site [polypeptide binding]; other site 251221005677 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 251221005678 The Mj1267/LivG ABC transporter subfamily is involved in the transport of the hydrophobic amino acids leucine, isoleucine and valine. MJ1267 is a branched-chain amino acid transporter with 29% similarity to both the LivF and LivG components of the E; Region: ABC_Mj1267_LivG_branched; cd03219 251221005679 Walker A/P-loop; other site 251221005680 ATP binding site [chemical binding]; other site 251221005681 Q-loop/lid; other site 251221005682 ABC transporter signature motif; other site 251221005683 Walker B; other site 251221005684 D-loop; other site 251221005685 H-loop/switch region; other site 251221005686 Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114 251221005687 Heat shock protein 33 (Hsp33): Cytosolic protein that acts as a molecular chaperone under oxidative conditions. In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498 251221005688 dimerization interface [polypeptide binding]; other site 251221005689 domain crossover interface; other site 251221005690 redox-dependent activation switch; other site 251221005691 Uncharacterized conserved protein [Function unknown]; Region: COG5592 251221005692 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 251221005693 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 251221005694 RPB12 interaction site [polypeptide binding]; other site 251221005695 RPB1 interaction site [polypeptide binding]; other site 251221005696 RPB10 interaction site [polypeptide binding]; other site 251221005697 RPB11 interaction site [polypeptide binding]; other site 251221005698 RPB3 interaction site [polypeptide binding]; other site 251221005699 Uncharacterized conserved protein [Function unknown]; Region: COG4715 251221005700 SWIM zinc finger; Region: SWIM; cl15408 251221005701 PemK-like protein; Region: PemK; cl00995 251221005702 Intradiol dioxygenases catalyze the critical ring-cleavage step in the conversion of catecholate derivatives to citric acid cycle intermediates. This family contains catechol 1,2-dioxygenases and protocatechuate 3,4-dioxygenases which are mononuclear...; Region: intradiol_dioxygenase; cd00421 251221005703 active site 251221005704 2-isopropylmalate synthase; Validated; Region: PRK00915 251221005705 2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940 251221005706 active site 251221005707 catalytic residues [active] 251221005708 metal binding site [ion binding]; metal-binding site 251221005709 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; cl07212 251221005710 Protein of unknown function (DUF2490); Region: DUF2490; pfam10677 251221005711 HEPN domain; Region: HEPN; cl00824 251221005712 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 251221005713 active site 251221005714 NTP binding site [chemical binding]; other site 251221005715 metal binding triad [ion binding]; metal-binding site 251221005716 antibiotic binding site [chemical binding]; other site 251221005717 Glutamate-cysteine ligase family 2(GCS2); Region: GCS2; cl00954 251221005718 carboxylate-amine ligase, YbdK family; Region: gshA_cyan_rel; TIGR02050 251221005719 ferredoxin--NADP+ reductase; Provisional; Region: PLN03116 251221005720 These ferredoxin reductases are related to the NADPH cytochrome p450 reductases (CYPOR), but lack the FAD-binding region connecting sub-domain. Ferredoxin-NADP+ reductase (FNR) is an FAD-containing enzyme that catalyzes the reversible electron transfer...; Region: CYPOR_like_FNR; cd06208 251221005721 dimerization interface [polypeptide binding]; other site 251221005722 FAD binding pocket [chemical binding]; other site 251221005723 FAD binding motif [chemical binding]; other site 251221005724 catalytic residues [active] 251221005725 NAD binding pocket [chemical binding]; other site 251221005726 phosphate binding motif [ion binding]; other site 251221005727 beta-alpha-beta structure motif; other site 251221005728 phosphoribulokinase; Provisional; Region: PRK07429 251221005729 Phosphoribulokinase (PRK) is an enzyme involved in the Benson-Calvin cycle in chloroplasts or photosynthetic prokaryotes. This enzyme catalyzes the phosphorylation of D-ribulose 5-phosphate to form D-ribulose 1, 5-biphosphate, using ATP and NADPH...; Region: PRK; cd02026 251221005730 active site 251221005731 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 251221005732 transketolase; Region: PLN02790 251221005733 TPP-binding site [chemical binding]; other site 251221005734 dimer interface [polypeptide binding]; other site 251221005735 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 251221005736 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 251221005737 PYR/PP interface [polypeptide binding]; other site 251221005738 dimer interface [polypeptide binding]; other site 251221005739 TPP binding site [chemical binding]; other site 251221005740 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 251221005741 DNA/RNA non-specific endonuclease; prokaryotic and eukaryotic double- and single-stranded DNA and RNA endonucleases also present in phosphodiesterases. They exists as monomers and homodimers; Region: NUC; cd00091 251221005742 DNA/RNA non-specific endonuclease; Region: Endonuclease_NS; smart00892 251221005743 active site 251221005744 substrate binding site [chemical binding]; other site 251221005745 Mg2+ binding site [ion binding]; other site 251221005746 Nuclease A inhibitor-like protein; Region: NuiA; pfam07924 251221005747 PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812 251221005748 RelB antitoxin; Region: RelB; cl01171 251221005749 Family description; Region: VCBS; pfam13517 251221005750 Family description; Region: VCBS; pfam13517 251221005751 KWG Leptospira; Region: KWG; pfam07656 251221005752 KWG Leptospira; Region: KWG; pfam07656 251221005753 KWG Leptospira; Region: KWG; pfam07656 251221005754 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 251221005755 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657 251221005756 dinuclear metal binding motif [ion binding]; other site 251221005757 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD includes...; Region: RuvC_resolvase; cl00243 251221005758 Uncharacterized protein conserved in bacteria with the myosin-like domain [Function unknown]; Region: COG4372 251221005759 Protein of unknown function (DUF3084); Region: DUF3084; pfam11283 251221005760 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 251221005761 Phosphopantetheine attachment site; Region: PP-binding; cl09936 251221005762 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 251221005763 Phosphoglycerate kinase; Region: PGK; pfam00162 251221005764 substrate binding site [chemical binding]; other site 251221005765 hinge regions; other site 251221005766 ADP binding site [chemical binding]; other site 251221005767 catalytic site [active] 251221005768 Fe-S oxidoreductase [Energy production and conversion]; Region: COG1032 251221005769 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 251221005770 B12 binding site [chemical binding]; other site 251221005771 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 251221005772 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 251221005773 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 251221005774 Mur ligase middle domain; Region: Mur_ligase_M; cl15713 251221005775 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 251221005776 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13905 251221005777 FAD binding domain; Region: FAD_binding_4; pfam01565 251221005778 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 251221005779 Gas vesicle synthesis protein GvpL/GvpF; Region: GvpL_GvpF; pfam06386 251221005780 Pro-kumamolisin, activation domain; Region: Pro-kuma_activ; cl07889 251221005781 Serine-pyruvate aminotransferase/archaeal aspartate aminotransferase [Amino acid transport and metabolism]; Region: COG0075 251221005782 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 251221005783 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 251221005784 catalytic residue [active] 251221005785 Thymidylate synthase complementing protein; Region: Thy1; cl03630 251221005786 D1, D2 subunits of photosystem II (PSII); M, L subunits of bacterial photosynthetic reaction center; Region: Photo_RC; cl08220 251221005787 pheophytin binding site; other site 251221005788 chlorophyll binding site; other site 251221005789 quinone binding site; other site 251221005790 Fe binding site [ion binding]; other site 251221005791 D1, D2 subunits of photosystem II (PSII); M, L subunits of bacterial photosynthetic reaction center; Region: Photo_RC; cl08220 251221005792 pheophytin binding site; other site 251221005793 chlorophyll binding site; other site 251221005794 quinone binding site; other site 251221005795 Fe binding site [ion binding]; other site 251221005796 Photosystem II protein; Region: PSII; cl08223 251221005797 photosystem II 44 kDa subunit reaction center protein (also called P6 protein, CP43), bacterial and chloroplast; Region: psbC; TIGR01153 251221005798 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 251221005799 DEAD-like helicases superfamily; Region: DEXDc; smart00487 251221005800 ATP binding site [chemical binding]; other site 251221005801 Mg++ binding site [ion binding]; other site 251221005802 motif III; other site 251221005803 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 251221005804 nucleotide binding region [chemical binding]; other site 251221005805 ATP-binding site [chemical binding]; other site 251221005806 RRM (RNA recognition motif), also known as RBD (RNA binding domain) or RNP (ribonucleoprotein domain), is a highly abundant domain in eukaryotes found in proteins involved in post-transcriptional gene expression processes including mRNA and rRNA...; Region: RRM; cd00590 251221005807 RNA/DNA binding site [nucleotide binding]; other site 251221005808 RRM dimerization site [polypeptide binding]; other site 251221005809 lipid A export permease/ATP-binding protein MsbA; Region: MsbA_lipidA; TIGR02203 251221005810 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 251221005811 MsbA is an essential ABC transporter, closely related to eukaryotic MDR proteins. ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars, ions, peptides, and more complex organic...; Region: ABCC_MsbA; cd03251 251221005812 Walker A/P-loop; other site 251221005813 ATP binding site [chemical binding]; other site 251221005814 Q-loop/lid; other site 251221005815 ABC transporter signature motif; other site 251221005816 Walker B; other site 251221005817 D-loop; other site 251221005818 H-loop/switch region; other site 251221005819 Peptidase family M23; Region: Peptidase_M23; pfam01551 251221005820 FUN14 family; Region: FUN14; cl01015 251221005821 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 251221005822 hydrolase; Region: PLN02578 251221005823 Protein of unknown function (DUF2993); Region: DUF2993; pfam11209 251221005824 Cytochrome c; Region: Cytochrom_C; cl11414 251221005825 Cytochrome c; Region: Cytochrom_C; cl11414 251221005826 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 251221005827 putative nucleotide binding site [chemical binding]; other site 251221005828 uridine monophosphate binding site [chemical binding]; other site 251221005829 homohexameric interface [polypeptide binding]; other site 251221005830 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; cl11412 251221005831 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 251221005832 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 251221005833 GatB domain; Region: GatB_Yqey; cl11497 251221005834 Conserved TM helix; Region: TM_helix; pfam05552 251221005835 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 251221005836 putative active site [active] 251221005837 beta-phosphoglucomutase family hydrolase; Region: PGMB-YQAB-SF; TIGR02009 251221005838 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 251221005839 active site 251221005840 motif I; other site 251221005841 motif II; other site 251221005842 Protein of unknown function (DUF3445); Region: DUF3445; pfam11927 251221005843 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 251221005844 putative active site [active] 251221005845 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 251221005846 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent formation of...; Region: AlaRS_core; cd00673 251221005847 motif 1; other site 251221005848 active site 251221005849 motif 2; other site 251221005850 motif 3; other site 251221005851 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; cl08469 251221005852 DHHA1 domain; Region: DHHA1; pfam02272 251221005853 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 251221005854 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it attaches...; Region: class_II_aaRS-like_core; cl00268 251221005855 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; cl08469 251221005856 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 251221005857 Amino acid permease; Region: AA_permease; cl00524 251221005858 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 251221005859 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 251221005860 Coenzyme A binding pocket [chemical binding]; other site 251221005861 undecaprenyl-phosphate alpha-N-acetylglucosaminyl 1-phosphatetransferase; Region: ECA_wecA; TIGR02380 251221005862 leucine ABC transporter subunit substrate-binding protein LivK; Provisional; Region: PRK15404 251221005863 Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342 251221005864 dimerization interface [polypeptide binding]; other site 251221005865 ligand binding site [chemical binding]; other site 251221005866 human dehydrogenase/reductase (SDR family) member 1 (DHRS1) -like, classical (c) SDRs; Region: DHRS1-like_SDR_c; cd09763 251221005867 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 251221005868 NAD(P) binding site [chemical binding]; other site 251221005869 putative dimer interface [polypeptide binding]; other site 251221005870 active site 251221005871 L-serine dehydratase, iron-sulfur-dependent, single chain form; Region: sda_mono; TIGR00720 251221005872 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 251221005873 Serine dehydratase alpha chain; Region: SDH_alpha; cl12120 251221005874 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; cl08040 251221005875 gamma-glutamyltranspeptidase; Region: g_glut_trans; TIGR00066 251221005876 Ribbon-helix-helix protein, copG family; Region: RHH_1; cl15375 251221005877 threonine synthase; Validated; Region: PRK08197 251221005878 Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants; Region: Thr-synth_1; cd01563 251221005879 homodimer interface [polypeptide binding]; other site 251221005880 pyridoxal 5'-phosphate binding site [chemical binding]; other site 251221005881 catalytic residue [active] 251221005882 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 251221005883 Protein of unknown function (DUF2470); Region: DUF2470; pfam10615 251221005884 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 251221005885 active site 251221005886 Uncharacterized conserved protein [Function unknown]; Region: COG2128 251221005887 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 251221005888 Pchlide_reductase_N: N protein of the NB protein complex of Protochlorophyllide (Pchlide)_reductase. Pchlide reductase catalyzes the reductive formation of chlorophyllide (chlide) from protochlorophyllide (pchlide) during biosynthesis of chlorophylls and...; Region: Pchlide_reductase_N; cd01979 251221005889 light-independent protochlorophyllide reductase, N subunit; Region: DPOR_bchN; TIGR01279 251221005890 photochlorophyllide reductase subunit L; Region: chlL; CHL00072 251221005891 This family of proteins contains bchL and chlL. Protochlorophyllide reductase catalyzes the reductive formation of chlorophyllide from protochlorophyllide during biosynthesis of chlorophylls and bacteriochlorophylls. Three genes, bchL, bchN and bchB, are...; Region: Bchl_like; cd02032 251221005892 P-loop; other site 251221005893 Protein of unknown function (DUF3155); Region: DUF3155; pfam11352 251221005894 Nickel-dependent hydrogenase; Region: NiFeSe_Hases; cl00417 251221005895 Respiratory-chain NADH dehydrogenase, 49 Kd subunit; Region: Complex1_49kDa; pfam00346 251221005896 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 251221005897 catalytic triad [active] 251221005898 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 251221005899 catalytic triad [active] 251221005900 D-alanyl-D-alanine carboxypeptidase; Region: VanY; cl00813 251221005901 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 251221005902 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 251221005903 active site 251221005904 HIGH motif; other site 251221005905 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 251221005906 active site 251221005907 KMSKS motif; other site 251221005908 NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; cl00419 251221005909 Respiratory-chain NADH dehydrogenase, 30 Kd subunit; Region: Complex1_30kDa; cl15698 251221005910 Phd_YefM; Region: PhdYeFM; cl09153 251221005911 PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812 251221005912 Nickel-dependent hydrogenase; Region: NiFeSe_Hases; cl00417 251221005913 Putative S-adenosyl-L-methionine-dependent methyltransferase; Region: Methyltransf_28; pfam02636 251221005914 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 251221005915 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 251221005916 Coenzyme A binding pocket [chemical binding]; other site 251221005917 SpoIID/LytB domain; Region: SpoIID_LytB; TIGR02669 251221005918 Beta-lactamase class A [Defense mechanisms]; Region: PenP; COG2367 251221005919 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 251221005920 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 251221005921 Ligand Binding Site [chemical binding]; other site 251221005922 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 251221005923 Ligand Binding Site [chemical binding]; other site 251221005924 TolB amino-terminal domain; Region: TolB_N; cl00639 251221005925 FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457 251221005926 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 251221005927 binding surface 251221005928 TPR motif; other site 251221005929 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 251221005930 binding surface 251221005931 TPR motif; other site 251221005932 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 251221005933 binding surface 251221005934 TPR motif; other site 251221005935 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 251221005936 TPR motif; other site 251221005937 binding surface 251221005938 ATP phosphoribosyltransferase regulatory subunit; Provisional; Region: hisZ; PRK12292 251221005939 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: HisRS-like_core; cd00773 251221005940 dimer interface [polypeptide binding]; other site 251221005941 motif 1; other site 251221005942 active site 251221005943 motif 2; other site 251221005944 motif 3; other site 251221005945 Uncharacterized conserved protein [Function unknown]; Region: COG3268 251221005946 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 251221005947 Protein of unknown function (DUF3539); Region: DUF3539; pfam12058 251221005948 ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073 251221005949 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 251221005950 Protein of unknown function (DUF433); Region: DUF433; cl01030 251221005951 Uncharacterized conserved protein [Function unknown]; Region: COG1656; cl09136 251221005952 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 251221005953 chaperone protein DnaJ; Provisional; Region: PRK14291 251221005954 HSP70 interaction site [polypeptide binding]; other site 251221005955 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 251221005956 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase; Region: murF; TIGR01143 251221005957 Mur ligase middle domain; Region: Mur_ligase_M; cl15713 251221005958 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 251221005959 Peptidase family M48; Region: Peptidase_M48; cl12018 251221005960 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 251221005961 Biopolymer transport protein ExbD/TolR; Region: ExbD; cl00537 251221005962 Gram-negative bacterial tonB protein; Region: TonB; cl10048 251221005963 Recombinational DNA repair ATPase (RecF pathway) [DNA replication, recombination, and repair]; Region: RecF; COG1195 251221005964 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 251221005965 Walker A/P-loop; other site 251221005966 ATP binding site [chemical binding]; other site 251221005967 Q-loop/lid; other site 251221005968 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 251221005969 ABC transporter signature motif; other site 251221005970 Walker B; other site 251221005971 D-loop; other site 251221005972 H-loop/switch region; other site 251221005973 DNA repair protein RadA; Provisional; Region: PRK11823 251221005974 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 251221005975 Walker A motif; other site 251221005976 ATP binding site [chemical binding]; other site 251221005977 Walker B motif; other site 251221005978 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 251221005979 Family 4 Uracil-DNA glycosylase (UDG), found exclusively in thermophilic organisms; Region: UDG_F4_TTUDGA_like; cd10030 251221005980 Fe-S cluster binding site [ion binding]; other site 251221005981 active site 251221005982 Pyroglutamyl peptidase (PGP) type I, also known as pyrrolidone carboxyl peptidase (pcp) type I: Enzymes responsible for cleaving pyroglutamate (pGlu) from the N-terminal end of specialized proteins. The N-terminal pGlu protects these proteins from...; Region: Peptidase_C15; cd00501 251221005983 putative substrate binding pocket [chemical binding]; other site 251221005984 AC domain interface; other site 251221005985 catalytic triad [active] 251221005986 AB domain interface; other site 251221005987 interchain disulfide; other site 251221005988 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 251221005989 putative active site [active] 251221005990 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 251221005991 active site 251221005992 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 251221005993 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 251221005994 Siderophore biosynthesis protein domain; Region: AlcB; cl11000 251221005995 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 251221005996 SWIM zinc finger; Region: SWIM; cl15408 251221005997 Superfamily II DNA/RNA helicases, SNF2 family [Transcription / DNA replication, recombination, and repair]; Region: HepA; COG0553 251221005998 SNF2 Helicase protein; Region: DUF3670; pfam12419 251221005999 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 251221006000 ATP binding site [chemical binding]; other site 251221006001 putative Mg++ binding site [ion binding]; other site 251221006002 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 251221006003 nucleotide binding region [chemical binding]; other site 251221006004 ATP-binding site [chemical binding]; other site 251221006005 Gloeo_Verruco repeat; Region: Gloeo_Verruco; TIGR03803 251221006006 Gloeo_Verruco repeat; Region: Gloeo_Verruco; TIGR03803 251221006007 Gloeo_Verruco repeat; Region: Gloeo_Verruco; TIGR03803 251221006008 Gloeo_Verruco repeat; Region: Gloeo_Verruco; TIGR03803 251221006009 Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819 251221006010 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 251221006011 active site 251221006012 TDP-binding site; other site 251221006013 acceptor substrate-binding pocket; other site 251221006014 homodimer interface [polypeptide binding]; other site 251221006015 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 251221006016 S-adenosylmethionine binding site [chemical binding]; other site 251221006017 Uncharacterized conserved protein (DUF2267); Region: DUF2267; cl02314 251221006018 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 251221006019 PemK-like protein; Region: PemK; cl00995 251221006020 Acidobacterial duplicated orphan permease; Region: ADOP; TIGR03434 251221006021 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 251221006022 FtsX-like permease family; Region: FtsX; pfam02687 251221006023 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 251221006024 FtsX-like permease family; Region: FtsX; pfam02687 251221006025 Helix-turn-helix domains; Region: HTH; cl00088 251221006026 PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812 251221006027 PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812 251221006028 putative active site [active] 251221006029 Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989 251221006030 Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750 251221006031 Competence protein A; Region: Competence_A; pfam11104 251221006032 Tfp pilus assembly protein PilN [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilN; COG3166 251221006033 Fimbrial assembly protein (PilN); Region: PilN; pfam05137 251221006034 type IV pilus secretin (or competence protein) PilQ; Region: IV_pilus_PilQ; TIGR02515 251221006035 Secretin and TonB N terminus short domain; Region: STN; cl06624 251221006036 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 251221006037 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 251221006038 Family description; Region: VCBS; pfam13517 251221006039 Family description; Region: VCBS; pfam13517 251221006040 competence damage-inducible protein A; Provisional; Region: PRK00549 251221006041 Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885 251221006042 putative MPT binding site; other site 251221006043 Competence-damaged protein; Region: CinA; cl00666 251221006044 Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466 251221006045 active site 251221006046 trimer interface [polypeptide binding]; other site 251221006047 dimer interface [polypeptide binding]; other site 251221006048 Glucose/sorbosone dehydrogenases [Carbohydrate transport and metabolism]; Region: COG2133 251221006049 Membrane bound L-sorbosone dehydrogenase; Region: SNDH; pfam12303 251221006050 Glucose / Sorbosone dehydrogenase; Region: GSDH; pfam07995 251221006051 PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812 251221006052 putative active site [active] 251221006053 Bacterial protein of unknown function (DUF839); Region: DUF839; pfam05787 251221006054 Bacterial protein of unknown function (DUF839); Region: DUF839; pfam05787 251221006055 CobD/Cbib protein; Region: CobD_Cbib; cl00561 251221006056 YCII-related domain; Region: YCII; cl00999 251221006057 hopanoid-associated sugar epimerase; Region: HpnA; TIGR03466 251221006058 uncharacterized subgroup of aldehyde reductase and flavonoid reductase related proteins, extended (e) SDRs; Region: AR_FR_like_1_SDR_e; cd05228 251221006059 putative NADP binding site [chemical binding]; other site 251221006060 putative substrate binding site [chemical binding]; other site 251221006061 active site 251221006062 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 251221006063 tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225 251221006064 DNA binding site [nucleotide binding] 251221006065 Int/Topo IB signature motif; other site 251221006066 active site 251221006067 tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291 251221006068 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 251221006069 TrmE (MnmE, ThdF, MSS1) is a 3-domain protein found in bacteria and eukaryotes. It controls modification of the uridine at the wobble position (U34) of tRNAs that read codons ending with A or G in the mixed codon family boxes. TrmE contains a GTPase...; Region: trmE; cd04164 251221006070 G1 box; other site 251221006071 GTP/Mg2+ binding site [chemical binding]; other site 251221006072 Switch I region; other site 251221006073 G2 box; other site 251221006074 Switch II region; other site 251221006075 G3 box; other site 251221006076 G4 box; other site 251221006077 G5 box; other site 251221006078 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 251221006079 Membrane Fusion Protein cluster 2 (function with RND porters); Region: 8a0102; TIGR00999 251221006080 Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538 251221006081 Predicted bile acid beta-glucosidase [Carbohydrate transport and metabolism]; Region: COG4354 251221006082 beta-Glucocerebrosidase 2 N terminal; Region: GBA2_N; pfam12215 251221006083 Bacterial alpha-L-rhamnosidase; Region: Bac_rhamnosid; cl01801 251221006084 Isoprenylcysteine carboxyl methyltransferase (ICMT) family; Region: ICMT; cl00763 251221006085 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 251221006086 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 251221006087 Magnesium ion binding site [ion binding]; other site 251221006088 colanic acid biosynthesis glycosyltransferase WcaL; Provisional; Region: PRK15427 251221006089 This is a family of GT1 glycosyltransferases found specifically in certain bacteria. amsK in Erwinia amylovora, has been reported to be involved in the biosynthesis of amylovoran, a exopolysaccharide acting as a virulence factor; Region: GT1_amsK_like; cd03799 251221006090 putative ADP-binding pocket [chemical binding]; other site 251221006091 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 251221006092 active site 251221006093 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 251221006094 Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819 251221006095 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 251221006096 homodimer interface [polypeptide binding]; other site 251221006097 active site 251221006098 TDP-binding site; other site 251221006099 acceptor substrate-binding pocket; other site 251221006100 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 251221006101 CRISPR-associated helicase Cas3, subtype CYANO; Region: cas3_cyano; TIGR03158 251221006102 WYL domain; Region: WYL; cl14852 251221006103 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 251221006104 putative active site [active] 251221006105 PemK-like protein; Region: PemK; cl00995 251221006106 Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548 251221006107 Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548 251221006108 Peptidase M14-like domain; uncharacterized subgroup; Region: M14-like_1_4; cd06241 251221006109 putative active site [active] 251221006110 Zn binding site [ion binding]; other site 251221006111 Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase [Amino acid transport and metabolism]; Region: HisC; COG0079 251221006112 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 251221006113 pyridoxal 5'-phosphate binding site [chemical binding]; other site 251221006114 homodimer interface [polypeptide binding]; other site 251221006115 catalytic residue [active] 251221006116 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 251221006117 folate binding site [chemical binding]; other site 251221006118 NADP+ binding site [chemical binding]; other site 251221006119 Protein of unknown function (DUF2973); Region: DUF2973; pfam11189 251221006120 Low-specificity threonine aldolase (TA). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). TA catalyzes the conversion of L-threonine or L-allo-threonine to glycine and acetaldehyde in a...; Region: TA_like; cd06502 251221006121 Beta-eliminating lyase; Region: Beta_elim_lyase; pfam01212 251221006122 tetramer interface [polypeptide binding]; other site 251221006123 pyridoxal 5'-phosphate binding site [chemical binding]; other site 251221006124 catalytic residue [active] 251221006125 nuc_hydro_ TvIAG: Nucleoside hydrolases similar to the Inosine-adenosine-guanosine-preferring nucleoside hydrolase from Trypanosoma vivax. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base; Region: nuc_hydro_TvIAG; cd02647 251221006126 active site 251221006127 dimerization interface [polypeptide binding]; other site 251221006128 putative lipid kinase; Reviewed; Region: PRK00861 251221006129 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; cl01255 251221006130 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 251221006131 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 251221006132 Catalytic site [active] 251221006133 Putative bacterial sensory transduction regulator; Region: YbjN; cl15834 251221006134 ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542 251221006135 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 251221006136 Walker A motif; other site 251221006137 ATP binding site [chemical binding]; other site 251221006138 Walker B motif; other site 251221006139 arginine finger; other site 251221006140 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 251221006141 Dehydrogenases (flavoproteins) [Energy production and conversion]; Region: FixC; COG0644 251221006142 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 251221006143 light-dependent protochlorophyllide reductase (LPOR)-like, classical (c)-like SDRs; Region: LPOR_like_SDR_c_like; cd09810 251221006144 short chain dehydrogenase; Provisional; Region: PRK06197 251221006145 putative NAD(P) binding site [chemical binding]; other site 251221006146 active site 251221006147 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 251221006148 dimer interface [polypeptide binding]; other site 251221006149 ssDNA binding site [nucleotide binding]; other site 251221006150 tetramer (dimer of dimers) interface [polypeptide binding]; other site 251221006151 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 251221006152 dimer interface [polypeptide binding]; other site 251221006153 ssDNA binding site [nucleotide binding]; other site 251221006154 tetramer (dimer of dimers) interface [polypeptide binding]; other site 251221006155 Alkyladenine DNA glycosylase catalyzes the first step in base excision repair; Region: AAG; cd00540 251221006156 active site 251221006157 DNA binding site [nucleotide binding] 251221006158 hypothetical protein; Provisional; Region: PRK10941 251221006159 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 251221006160 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 251221006161 Helix-turn-helix domains; Region: HTH; cl00088 251221006162 cellulose synthase regulator protein; Provisional; Region: PRK11114 251221006163 Predicted outer membrane protein [Function unknown]; Region: COG3652 251221006164 Uncharacterised ACR, COG2135; Region: DUF159; cl03646 251221006165 glutamine synthetase, type III; Region: gln_synth_III; TIGR03105 251221006166 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 251221006167 homoserine O-acetyltransferase; Provisional; Region: metX; cl15472 251221006168 homoserine O-acetyltransferase; Region: homoserO_Ac_trn; TIGR01392 251221006169 This CD includes the putative hydrocarbon oxygenase, MocD, a bacterial rhizopine (3-O-methyl-scyllo-inosamine, 3-O-MSI) oxygenase, and other related proteins. It has been proposed that MocD, MocE (Rieske-like ferredoxin), and MocF (ferredoxin reductase)...; Region: Rhizopine-oxygenase-like; cd03511 251221006170 Fatty acid desaturase; Region: FA_desaturase; pfam00487 251221006171 putative di-iron ligands [ion binding]; other site 251221006172 Cadmium resistance transporter; Region: Cad; cl04177 251221006173 pyrimidine utilization regulatory protein R; Region: RutR; TIGR03613 251221006174 DNA gyrase subunit B; Validated; Region: gyrB; PRK05644 251221006175 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 251221006176 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 251221006177 anchoring element; other site 251221006178 dimer interface [polypeptide binding]; other site 251221006179 ATP binding site [chemical binding]; other site 251221006180 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 251221006181 active site 251221006182 putative metal-binding site [ion binding]; other site 251221006183 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 251221006184 Domain of unknown function DUF28; Region: DUF28; cl00361 251221006185 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 251221006186 DEAD-like helicases superfamily; Region: DEXDc; smart00487 251221006187 ATP binding site [chemical binding]; other site 251221006188 Mg++ binding site [ion binding]; other site 251221006189 motif III; other site 251221006190 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 251221006191 nucleotide binding region [chemical binding]; other site 251221006192 ATP-binding site [chemical binding]; other site 251221006193 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 251221006194 active site 251221006195 metal binding site [ion binding]; metal-binding site 251221006196 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 251221006197 Protein of unknown function (DUF3574); Region: DUF3574; pfam12098 251221006198 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 251221006199 active site 251221006200 dimer interface [polypeptide binding]; other site 251221006201 metal binding site [ion binding]; metal-binding site 251221006202 Serine acetyltransferase, N-terminal; Region: SATase_N; cl05762 251221006203 serine O-acetyltransferase; Region: cysE; TIGR01172 251221006204 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 251221006205 trimer interface [polypeptide binding]; other site 251221006206 active site 251221006207 substrate binding site [chemical binding]; other site 251221006208 CoA binding site [chemical binding]; other site 251221006209 Domain of unknown function DUF29; Region: DUF29; pfam01724 251221006210 Peptide methionine sulfoxide reductase; Region: PMSR; cl00366 251221006211 N-6 DNA Methylase; Region: N6_Mtase; pfam02384 251221006212 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 251221006213 3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK05952 251221006214 dimer interface [polypeptide binding]; other site 251221006215 active site 251221006216 Protein of unknown function (DUF2808); Region: DUF2808; pfam10989 251221006217 prolyl-tRNA synthetase; Provisional; Region: PRK09194 251221006218 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent formation of...; Region: ProRS_core_prok; cd00779 251221006219 dimer interface [polypeptide binding]; other site 251221006220 motif 1; other site 251221006221 active site 251221006222 motif 2; other site 251221006223 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334 251221006224 putative deacylase active site [active] 251221006225 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it attaches...; Region: class_II_aaRS-like_core; cl00268 251221006226 active site 251221006227 motif 3; other site 251221006228 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 251221006229 anticodon binding site; other site 251221006230 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 251221006231 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 251221006232 cytosine deaminase; Provisional; Region: PRK05985 251221006233 Bacterial cytosine deaminase and related metal-dependent hydrolases. Cytosine deaminases (CDs) catalyze the deamination of cytosine, producing uracil and ammonia. They play an important role in pyrimidine salvage. CDs are present in prokaryotes and fungi; Region: Bact_CD; cd01293 251221006234 active site 251221006235 Ribosomal protein S21; Region: Ribosomal_S21; cl00529 251221006236 RRM (RNA recognition motif), also known as RBD (RNA binding domain) or RNP (ribonucleoprotein domain), is a highly abundant domain in eukaryotes found in proteins involved in post-transcriptional gene expression processes including mRNA and rRNA...; Region: RRM; cd00590 251221006237 RNA/DNA binding site [nucleotide binding]; other site 251221006238 RRM dimerization site [polypeptide binding]; other site 251221006239 ATP-dependent Clp protease adaptor protein ClpS; Region: ClpS; cl00933 251221006240 Pirin-related protein [General function prediction only]; Region: COG1741 251221006241 Cupin domain; Region: Cupin_2; cl09118 251221006242 Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726 251221006243 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 251221006244 hypothetical protein; Provisional; Region: PRK08185 251221006245 intersubunit interface [polypeptide binding]; other site 251221006246 active site 251221006247 zinc binding site [ion binding]; other site 251221006248 Na+ binding site [ion binding]; other site 251221006249 Uncharacterised protein family (UPF0156); Region: RHH_2; cl01448 251221006250 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 251221006251 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 251221006252 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 251221006253 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 251221006254 proton-translocating NADH-quinone oxidoreductase, chain M; Region: NDH_I_M; TIGR01972 251221006255 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; cl14187 251221006256 H+ Antiporter protein; Region: 2A0121; TIGR00900 251221006257 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4370 251221006258 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 251221006259 M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886 251221006260 amidohydrolase; Region: amidohydrolases; TIGR01891 251221006261 metal binding site [ion binding]; metal-binding site 251221006262 dimer interface [polypeptide binding]; other site 251221006263 Domain of unknown function (DUF1816); Region: DUF1816; pfam08846 251221006264 malate dehydrogenase; Reviewed; Region: PRK06223 251221006265 L-lactate dehydrogenase-like malate dehydrogenase proteins; Region: LDH-like_MDH; cd01339 251221006266 NAD(P) binding site [chemical binding]; other site 251221006267 dimer interface [polypeptide binding]; other site 251221006268 tetramer (dimer of dimers) interface [polypeptide binding]; other site 251221006269 substrate binding site [chemical binding]; other site 251221006270 Coenzyme F420 hydrogenase/dehydrogenase, beta subunit N-term; Region: FrhB_FdhB_N; pfam04422 251221006271 Coenzyme F420 hydrogenase/dehydrogenase, beta subunit C terminus; Region: FrhB_FdhB_C; pfam04432 251221006272 Cobalamin synthesis G N-terminal; Region: CbiG_N; pfam11760 251221006273 Cobalamin biosynthesis central region; Region: CbiG_mid; pfam11761 251221006274 Cobalamin synthesis G C-terminus; Region: CbiG_C; cl12133 251221006275 Tetrapyrrole (Corrin/Porphyrin) Methylases; Region: TP_methylase; cl00304 251221006276 Interphotoreceptor retinoid-binding protein; serine protease family S41; Region: Peptidase_S41_IRBP; cd07563 251221006277 active site triad [active] 251221006278 AIPR protein; Region: AIPR; pfam10592 251221006279 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 251221006280 enoyl-CoA hydratase; Provisional; Region: PRK06688 251221006281 substrate binding site [chemical binding]; other site 251221006282 oxyanion hole (OAH) forming residues; other site 251221006283 trimer interface [polypeptide binding]; other site 251221006284 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 251221006285 NAD(P) binding site [chemical binding]; other site 251221006286 active site 251221006287 Transcriptional regulator [Transcription]; Region: LysR; COG0583 251221006288 Helix-turn-helix domains; Region: HTH; cl00088 251221006289 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 251221006290 putative effector binding pocket; other site 251221006291 dimerization interface [polypeptide binding]; other site 251221006292 PAP_fibrillin; Region: PAP_fibrillin; pfam04755 251221006293 FOG: HEAT repeat [Energy production and conversion]; Region: COG1413 251221006294 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 251221006295 active site 251221006296 ribulose/triose binding site [chemical binding]; other site 251221006297 phosphate binding site [ion binding]; other site 251221006298 substrate (anthranilate) binding pocket [chemical binding]; other site 251221006299 product (indole) binding pocket [chemical binding]; other site 251221006300 histidyl-tRNA synthetase; Region: hisS; TIGR00442 251221006301 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: HisRS-like_core; cd00773 251221006302 dimer interface [polypeptide binding]; other site 251221006303 motif 1; other site 251221006304 active site 251221006305 motif 2; other site 251221006306 motif 3; other site 251221006307 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 251221006308 anticodon binding site; other site 251221006309 Protein of unknown function (DUF2396); Region: DUF2396; cl09868 251221006310 CESA_like is the cellulose synthase superfamily; Region: CESA_like; cd06423 251221006311 DXD motif; other site 251221006312 Transposase, Mutator family; Region: Transposase_mut; pfam00872 251221006313 MULE transposase domain; Region: MULE; pfam10551 251221006314 Transposase, Mutator family; Region: Transposase_mut; pfam00872 251221006315 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 251221006316 Aldose 1-epimerase, similar to Synechocystis Slr1438; Region: Aldose_epim_Slr1438; cd09025 251221006317 active site 251221006318 catalytic residues [active] 251221006319 Replication protein A, class 2b aminoacyl-tRNA synthetases, and related proteins with oligonucleotide/oligosaccharide (OB) fold; Region: RPA_2b-aaRSs_OBF_like; cl09930 251221006320 Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980 251221006321 dimer interface [polypeptide binding]; other site 251221006322 [2Fe-2S] cluster binding site [ion binding]; other site 251221006323 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 251221006324 Ferritin-like domain; Region: Ferritin; pfam00210 251221006325 dimerization interface [polypeptide binding]; other site 251221006326 DPS ferroxidase diiron center [ion binding]; other site 251221006327 ion pore; other site 251221006328 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 251221006329 ATP synthase, Delta/Epsilon chain, beta-sandwich domain; Region: ATP-synt_DE_N; cl10033 251221006330 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 251221006331 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 251221006332 E3 interaction surface; other site 251221006333 lipoyl attachment site [posttranslational modification]; other site 251221006334 e3 binding domain; Region: E3_binding; pfam02817 251221006335 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; cl02008 251221006336 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 251221006337 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; cl15275 251221006338 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 251221006339 alpha subunit interaction interface [polypeptide binding]; other site 251221006340 Walker A motif; other site 251221006341 ATP binding site [chemical binding]; other site 251221006342 Walker B motif; other site 251221006343 inhibitor binding site; inhibition site 251221006344 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 251221006345 Protein of unknown function (DUF2808); Region: DUF2808; pfam10989 251221006346 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 251221006347 RNA polymerase sigma factor, cyanobacterial RpoD-like family; Region: Sig70-cyanoRpoD; TIGR02997 251221006348 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 251221006349 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 251221006350 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 251221006351 DNA binding residues [nucleotide binding] 251221006352 O-Antigen ligase; Region: Wzy_C; cl04850 251221006353 Domain of unknown function DUF29; Region: DUF29; pfam01724 251221006354 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 251221006355 putative active site [active] 251221006356 S-adenosylmethionine synthetase; Validated; Region: PRK05250 251221006357 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 251221006358 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 251221006359 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 251221006360 FtsH Extracellular; Region: FtsH_ext; pfam06480 251221006361 cell division protein; Validated; Region: ftsH; CHL00176 251221006362 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 251221006363 Walker A motif; other site 251221006364 ATP binding site [chemical binding]; other site 251221006365 Walker B motif; other site 251221006366 arginine finger; other site 251221006367 Peptidase family M41; Region: Peptidase_M41; pfam01434 251221006368 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_N; cd03416 251221006369 Sirohydrochlorin ferrochelatase [Inorganic ion transport and metabolism]; Region: COG2138 251221006370 putative active site [active] 251221006371 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), C-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_C; cd03414 251221006372 putative active site [active] 251221006373 Tetrapyrrole (Corrin/Porphyrin) Methylases; Region: TP_methylase; cl00304 251221006374 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 251221006375 putative active site [active] 251221006376 PyridoxaL 5'-Phosphate Dependent Enzymes class IV (PLPDE_IV). This D-amino acid superfamily, one of five classes of PLPDE, consists of branched-chain amino acid aminotransferases (BCAT), D-amino acid transferases (DAAT), and 4-amino-4-deoxychorismate...; Region: PLPDE_IV; cl00224 251221006377 homodimer interface [polypeptide binding]; other site 251221006378 substrate-cofactor binding pocket; other site 251221006379 Aminotransferase class IV; Region: Aminotran_4; pfam01063 251221006380 pyridoxal 5'-phosphate binding site [chemical binding]; other site 251221006381 catalytic residue [active] 251221006382 Predicted integral membrane protein (DUF2189); Region: DUF2189; cl02291 251221006383 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 251221006384 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 251221006385 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 251221006386 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 251221006387 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 251221006388 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 251221006389 NAD synthetase; Provisional; Region: PRK13981 251221006390 Glutamine aminotransferase (GAT, glutaminase) domain of glutamine-dependent NAD synthetases (class 7 and 8 nitrilases); Region: GAT_Gln-NAD-synth; cd07570 251221006391 multimer interface [polypeptide binding]; other site 251221006392 active site 251221006393 catalytic triad [active] 251221006394 protein interface 1 [polypeptide binding]; other site 251221006395 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 251221006396 homodimer interface [polypeptide binding]; other site 251221006397 NAD binding pocket [chemical binding]; other site 251221006398 ATP binding pocket [chemical binding]; other site 251221006399 Mg binding site [ion binding]; other site 251221006400 active-site loop [active] 251221006401 Clp protease ATP binding subunit; Region: clpC; CHL00095 251221006402 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cl01898 251221006403 Ferredoxin-dependent bilin reductase; Region: Fe_bilin_red; cl07930 251221006404 radical SAM family uncharacterized protein; Region: rSAM_fuse_unch; TIGR03960 251221006405 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 251221006406 B12 binding site [chemical binding]; other site 251221006407 Protein containing tetrapyrrole methyltransferase domain and MazG-like (predicted pyrophosphatase) domain [General function prediction only]; Region: COG3956 251221006408 Tetrapyrrole (Corrin/Porphyrin) Methylases; Region: TP_methylase; cl00304 251221006409 MazG nucleotide pyrophosphohydrolase domain; Region: MazG; cl00345 251221006410 MazG nucleotide pyrophosphohydrolase domain; Region: MazG; cl00345 251221006411 Superfamily II RNA helicase [DNA replication, recombination, and repair]; Region: COG4581 251221006412 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 251221006413 ATP binding site [chemical binding]; other site 251221006414 putative Mg++ binding site [ion binding]; other site 251221006415 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 251221006416 nucleotide binding region [chemical binding]; other site 251221006417 ATP-binding site [chemical binding]; other site 251221006418 DSHCT (NUC185) domain; Region: DSHCT; pfam08148 251221006419 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 251221006420 active site 251221006421 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 251221006422 NADH:ubiquinone oxidoreductase subunit L; Reviewed; Region: PRK06590 251221006423 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662 251221006424 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; cl14187 251221006425 aspartate aminotransferase; Provisional; Region: PRK05764 251221006426 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 251221006427 pyridoxal 5'-phosphate binding site [chemical binding]; other site 251221006428 homodimer interface [polypeptide binding]; other site 251221006429 catalytic residue [active] 251221006430 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 251221006431 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 251221006432 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 251221006433 catalytic residue [active] 251221006434 Uncharacterized protein conserved in bacteria (DUF2257); Region: DUF2257; cl01794 251221006435 Membrane bound L-sorbosone dehydrogenase; Region: SNDH; pfam12303 251221006436 Glucose/sorbosone dehydrogenases [Carbohydrate transport and metabolism]; Region: COG2133 251221006437 TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056 251221006438 PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812 251221006439 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cl00197 251221006440 active site 251221006441 multifunctional aminopeptidase A; Provisional; Region: PRK00913 251221006442 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 251221006443 interface (dimer of trimers) [polypeptide binding]; other site 251221006444 Substrate-binding/catalytic site; other site 251221006445 Zn-binding sites [ion binding]; other site 251221006446 tryptophan synthase alpha subunit; Provisional; Region: trpA; CHL00200 251221006447 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 251221006448 substrate binding site [chemical binding]; other site 251221006449 active site 251221006450 catalytic residues [active] 251221006451 heterodimer interface [polypeptide binding]; other site 251221006452 Plasmid stabilisation system protein; Region: Plasmid_stabil; cl11422 251221006453 N-acetylmannosamine-6-phosphate epimerase (NanE) converts N-acetylmannosamine-6-phosphate to N-acetylglucosamine-6-phosphate. This reaction is part of the pathway that allows the usage of sialic acid as a carbohydrate source. Sialic acids are a family of...; Region: NanE; cd04729 251221006454 putative active site cavity [active] 251221006455 GMP synthase; Reviewed; Region: guaA; PRK00074 251221006456 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 251221006457 AMP/PPi binding site [chemical binding]; other site 251221006458 candidate oxyanion hole; other site 251221006459 catalytic triad [active] 251221006460 potential glutamine specificity residues [chemical binding]; other site 251221006461 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 251221006462 ATP Binding subdomain [chemical binding]; other site 251221006463 Ligand Binding sites [chemical binding]; other site 251221006464 Dimerization subdomain; other site 251221006465 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cl01898 251221006466 tellurite resistance protein terB; Region: terB; cd07176 251221006467 putative metal binding site [ion binding]; other site 251221006468 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 251221006469 putative active site [active] 251221006470 Transposase [DNA replication, recombination, and repair]; Region: COG5421 251221006471 magnesium chelatase subunit H; Provisional; Region: PRK12493 251221006472 Domain of unknown function (DUF3479); Region: DUF3479; pfam11965 251221006473 CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150 251221006474 CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150 251221006475 Fatty acid desaturase; Region: FA_desaturase; pfam00487 251221006476 The Delta12 Fatty Acid Desaturase (Delta12-FADS)-like CD includes the integral-membrane enzymes, delta-12 acyl-lipid desaturases, oleate 12-hydroxylases, omega3 and omega6 fatty acid desaturases, and other related proteins, found in a wide range of...; Region: Delta12-FADS-like; cd03507 251221006477 putative di-iron ligands [ion binding]; other site 251221006478 Glycosyl hydrolase family 57; Region: Glyco_hydro_57; pfam03065 251221006479 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 251221006480 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 251221006481 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 251221006482 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 251221006483 GAF domain; Region: GAF; cl00853 251221006484 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 251221006485 dimer interface [polypeptide binding]; other site 251221006486 sensory histidine kinase CreC; Provisional; Region: PRK11100 251221006487 phosphorylation site [posttranslational modification] 251221006488 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 251221006489 ATP binding site [chemical binding]; other site 251221006490 Mg2+ binding site [ion binding]; other site 251221006491 G-X-G motif; other site 251221006492 Peptidase S46; Region: Peptidase_S46; pfam10459 251221006493 ATP-dependent DNA helicase RecQ; Region: recQ; TIGR01389 251221006494 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 251221006495 ATP binding site [chemical binding]; other site 251221006496 putative Mg++ binding site [ion binding]; other site 251221006497 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 251221006498 nucleotide binding region [chemical binding]; other site 251221006499 ATP-binding site [chemical binding]; other site 251221006500 RQC domain; Region: RQC; cl09632 251221006501 HRDC domain; Region: HRDC; cl02578 251221006502 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4955 251221006503 CO2 hydration protein (ChpXY); Region: ChpXY; cl10905 251221006504 Domain of unknown function (DUF309); Region: DUF309; cl00667 251221006505 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 251221006506 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 251221006507 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 251221006508 Ribosomal protein S21; Region: Ribosomal_S21; cl00529 251221006509 Predicted RNA-binding protein (contains KH domain) [General function prediction only]; Region: COG1837 251221006510 hypothetical protein; Provisional; Region: PRK00468; cl00794 251221006511 Ribosomal protein S16; Region: Ribosomal_S16; cl00368 251221006512 signal recognition particle protein; Provisional; Region: PRK10867 251221006513 SRP54-type protein, helical bundle domain; Region: SRP54_N; cl03758 251221006514 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 251221006515 P loop; other site 251221006516 GTP binding site [chemical binding]; other site 251221006517 Signal peptide binding domain; Region: SRP_SPB; pfam02978 251221006518 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 251221006519 RfaE encodes a bifunctional ADP-heptose synthase involved in the biosynthesis of the lipopolysaccharide (LPS) core precursor ADP-L-glycero-D-manno-heptose. LPS plays an important role in maintaining the structural integrity of the bacterial outer...; Region: RfaE_like; cd01172 251221006520 putative ribose interaction site [chemical binding]; other site 251221006521 putative ADP binding site [chemical binding]; other site 251221006522 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 251221006523 Cytidylyltransferase; Region: CTP_transf_2; pfam01467 251221006524 active site 251221006525 nucleotide binding site [chemical binding]; other site 251221006526 HIGH motif; other site 251221006527 KMSKS motif; other site 251221006528 CysQ, a 3'-Phosphoadenosine-5'-phosphosulfate (PAPS) 3'-phosphatase, is a bacterial member of the inositol monophosphatase family. It has been proposed that CysQ helps control intracellular levels of PAPS, which is an intermediate in cysteine...; Region: CysQ; cd01638 251221006529 active site 251221006530 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cl00264 251221006531 Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as Transcription factor ImmunoGlobin (TIG) domains. They are present in intracellular transcription factors, cell surface receptors (such as plexins and scatter factor...; Region: IPT; cl15674 251221006532 BtpA family; Region: BtpA; cl00440 251221006533 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 251221006534 catalytic center binding site [active] 251221006535 ATP binding site [chemical binding]; other site 251221006536 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 251221006537 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 251221006538 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 251221006539 dimerization interface [polypeptide binding]; other site 251221006540 active site 251221006541 metal binding site [ion binding]; metal-binding site 251221006542 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 251221006543 dsRNA binding site [nucleotide binding]; other site 251221006544 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 251221006545 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 251221006546 ATP binding site [chemical binding]; other site 251221006547 Walker B motif; other site 251221006548 arginine finger; other site 251221006549 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 251221006550 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 251221006551 Walker A motif; other site 251221006552 ATP binding site [chemical binding]; other site 251221006553 Walker B motif; other site 251221006554 arginine finger; other site 251221006555 Peptidase family M41; Region: Peptidase_M41; pfam01434 251221006556 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 251221006557 binding surface 251221006558 TPR motif; other site 251221006559 Ylxr homologs; group of conserved hypothetical bacterial proteins of unknown function; structure revealed putative RNA binding cleft; proteins are encoded by an operon that includes other proteins involved in transcription and/or translation; Region: YlxR; cl00189 251221006560 translation initiation factor IF-2; Validated; Region: infB; PRK05306 251221006561 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 251221006562 translation initiation factor IF-2; Region: IF-2; TIGR00487 251221006563 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 251221006564 IF2/eIF5B (initiation factors 2/ eukaryotic initiation factor 5B) subfamily. IF2/eIF5B contribute to ribosomal subunit joining and function as GTPases that are maximally activated by the presence of both ribosomal subunits. As seen in other GTPases; Region: IF2_eIF5B; cd01887 251221006565 G1 box; other site 251221006566 putative GEF interaction site [polypeptide binding]; other site 251221006567 GTP/Mg2+ binding site [chemical binding]; other site 251221006568 Switch I region; other site 251221006569 G2 box; other site 251221006570 G3 box; other site 251221006571 Switch II region; other site 251221006572 G4 box; other site 251221006573 G5 box; other site 251221006574 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 251221006575 Translation-initiation factor 2; Region: IF-2; pfam11987 251221006576 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 251221006577 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 251221006578 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 251221006579 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 251221006580 structural tetrad; other site 251221006581 FOG: WD40 repeat [General function prediction only]; Region: COG2319 251221006582 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 251221006583 D1, D2 subunits of photosystem II (PSII); M, L subunits of bacterial photosynthetic reaction center; Region: Photo_RC; cl08220 251221006584 ketol-acid reductoisomerase; Provisional; Region: PRK05479 251221006585 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 251221006586 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 251221006587 PA_C5a_like: Protease-associated domain containing proteins like Streptococcus pyogenes C5a peptidase. This group contains various PA domain-containing proteins similar to S. pyogenes C5a, including, i) Vpr, a minor extracellular serine protease from...; Region: PA_C5a_like; cd02133 251221006588 putative integrin binding motif; other site 251221006589 PA/protease domain interface [polypeptide binding]; other site 251221006590 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 251221006591 metal binding site [ion binding]; metal-binding site 251221006592 putative PEP-CTERM system TPR-repeat lipoprotein; Region: PEP_TPR_lipo; TIGR02917 251221006593 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 251221006594 binding surface 251221006595 TPR motif; other site 251221006596 Uncharacterised protein family (UPF0175); Region: UPF0175; cl01085 251221006597 Predicted transcriptional regulator [Transcription]; Region: COG5340 251221006598 Nucleotidyl transferase of unknown function (DUF1814); Region: DUF1814; cl00973 251221006599 Nucleotidyl transferase of unknown function (DUF1814); Region: DUF1814; cl00973 251221006600 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 251221006601 putative active site [active] 251221006602 general secretion pathway protein F; Region: GspF; TIGR02120 251221006603 pilus retraction protein PilT; Region: pilT_fam; TIGR01420 251221006604 Pilus retraction ATPase PilT. PilT is a nucleotide binding protein responsible for the retraction of type IV pili, likely by pili disassembly. This retraction provides the force required for travel of bacteria in low water environments by a mechanism...; Region: PilT; cd01131 251221006605 Walker A motif; other site 251221006606 ATP binding site [chemical binding]; other site 251221006607 Walker B motif; other site 251221006608 GSPII_E N-terminal domain; Region: GSPII_E_N; pfam05157 251221006609 Type II secretory pathway, ATPase PulE/Tfp pilus assembly pathway, ATPase PilB [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulE; COG2804 251221006610 PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129 251221006611 Walker A motif; other site 251221006612 ATP binding site [chemical binding]; other site 251221006613 Walker B motif; other site 251221006614 RNA polymerase sigma factor SigF; Reviewed; Region: PRK07408 251221006615 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 251221006616 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 251221006617 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 251221006618 DNA binding residues [nucleotide binding] 251221006619 Ycf27; Reviewed; Region: orf27; CHL00148 251221006620 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 251221006621 active site 251221006622 phosphorylation site [posttranslational modification] 251221006623 intermolecular recognition site; other site 251221006624 dimerization interface [polypeptide binding]; other site 251221006625 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 251221006626 DNA binding site [nucleotide binding] 251221006627 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 251221006628 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 251221006629 catalytic residue [active] 251221006630 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 251221006631 S-adenosylmethionine binding site [chemical binding]; other site 251221006632 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl12011 251221006633 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 251221006634 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 251221006635 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 251221006636 Walker A/P-loop; other site 251221006637 ATP binding site [chemical binding]; other site 251221006638 Q-loop/lid; other site 251221006639 ABC transporter signature motif; other site 251221006640 Walker B; other site 251221006641 D-loop; other site 251221006642 H-loop/switch region; other site 251221006643 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 251221006644 putative active site [active] 251221006645 putative transposase OrfB; Reviewed; Region: PHA02517 251221006646 Integrase core domain; Region: rve; cl01316 251221006647 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 251221006648 Helix-turn-helix domains; Region: HTH; cl00088 251221006649 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316 251221006650 Integrase core domain; Region: rve; cl01316 251221006651 Integrase core domain; Region: rve; cl01316 251221006652 TfoX N-terminal domain; Region: TfoX_N; cl01167 251221006653 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 251221006654 Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175 251221006655 Clavaminic acid synthetase (CAS) -like; CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cl00184 251221006656 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 251221006657 Helix-turn-helix domains; Region: HTH; cl00088 251221006658 Helix-turn-helix domains; Region: HTH; cl00088 251221006659 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 251221006660 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 251221006661 Coenzyme A binding pocket [chemical binding]; other site 251221006662 Helix-turn-helix domains; Region: HTH; cl00088 251221006663 Helix-turn-helix domain of transposase family ISL3; Region: HTH_Tnp_ISL3; pfam13542 251221006664 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 251221006665 iron-sulfur cluster [ion binding]; other site 251221006666 [2Fe-2S] cluster binding site [ion binding]; other site 251221006667 PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812 251221006668 putative active site [active] 251221006669 Protein of unknown function (DUF433); Region: DUF433; cl01030 251221006670 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 251221006671 Ligand Binding Site [chemical binding]; other site 251221006672 Domain of unknown function (DUF205); Region: DUF205; cl00410 251221006673 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 251221006674 phosphoenolpyruvate synthase; Validated; Region: PRK06241 251221006675 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; cl01586 251221006676 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 251221006677 TM-ABC transporter signature motif; other site 251221006678 Predicted oxidoreductases (related to aryl-alcohol dehydrogenases) [Energy production and conversion]; Region: Tas; COG0667 251221006679 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 251221006680 active site 251221006681 catalytic tetrad [active] 251221006682 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 251221006683 GST_N family, unknown subfamily 4; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_4; cd03056 251221006684 putative C-terminal domain interface [polypeptide binding]; other site 251221006685 putative GSH binding site (G-site) [chemical binding]; other site 251221006686 putative dimer interface [polypeptide binding]; other site 251221006687 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776 251221006688 N-terminal domain interface [polypeptide binding]; other site 251221006689 dimer interface [polypeptide binding]; other site 251221006690 substrate binding pocket (H-site) [chemical binding]; other site 251221006691 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149 251221006692 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 251221006693 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 251221006694 [2Fe-2S] cluster binding site [ion binding]; other site 251221006695 C-terminal catalytic domain of the oxygenase alpha subunit of Rieske-type non-heme iron aromatic ring-hydroxylating oxygenases; Region: RHO_alpha_C; cd00680 251221006696 alpha subunit interface [polypeptide binding]; other site 251221006697 active site 251221006698 substrate binding site [chemical binding]; other site 251221006699 Fe binding site [ion binding]; other site 251221006700 NHL repeat; Region: NHL; pfam01436 251221006701 haloacid dehalogenase-like hydrolase family protein; Region: PLN02919 251221006702 NHL repeat; Region: NHL; pfam01436 251221006703 haloacid dehalogenase-like hydrolase family protein; Region: PLN02919 251221006704 NHL repeat; Region: NHL; pfam01436 251221006705 NHL repeat; Region: NHL; pfam01436 251221006706 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 251221006707 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 251221006708 putative dimer interface [polypeptide binding]; other site 251221006709 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT; cl15364 251221006710 Chorismate mutase (AroH) is one of at least five chorismate-utilizing enzymes present in microorganisms that catalyze the rearrangement of chorismate to prephenic acid, the first committed step in the biosynthesis of aromatic amino acids. In prokaryotes; Region: AroH; cd02185 251221006711 homotrimer interaction site [polypeptide binding]; other site 251221006712 active site 251221006713 FAD dependent oxidoreductase; Region: FAD_oxidored; pfam12831 251221006714 Anti-sigma-K factor rskA; Region: RskA; cl15366 251221006715 Cupin domain; Region: Cupin_2; cl09118 251221006716 RNA polymerase sigma factor; Provisional; Region: PRK12519 251221006717 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 251221006718 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 251221006719 DNA binding residues [nucleotide binding] 251221006720 D12 class N6 adenine-specific DNA methyltransferase; Region: MethyltransfD12; cl00408 251221006721 shikimate kinase; Reviewed; Region: aroK; PRK00131 251221006722 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 251221006723 ADP binding site [chemical binding]; other site 251221006724 magnesium binding site [ion binding]; other site 251221006725 putative shikimate binding site; other site 251221006726 Lipid A disaccharide synthetase [Cell envelope biogenesis, outer membrane]; Region: LpxB; COG0763 251221006727 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Provisional; Region: lpxD; PRK00892 251221006728 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase, LpxD; Region: LpxD; pfam04613 251221006729 UDP-3-O-acyl-glucosamine N-acyltransferase (LpxD): The enzyme catalyzes the transfer of 3-hydroxymyristic acid or 3-hydroxy-arachidic acid, depending on the organism, from the acyl carrier protein (ACP) to UDP-3-O-acyl-glucosamine to produce UDP-2; Region: LbH_LpxD; cd03352 251221006730 trimer interface [polypeptide binding]; other site 251221006731 active site 251221006732 UDP-GlcNAc binding site [chemical binding]; other site 251221006733 lipid binding site [chemical binding]; lipid-binding site 251221006734 light-harvesting-like protein 3; Provisional; Region: PLN00014 251221006735 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 251221006736 active site 251221006737 dimer interface [polypeptide binding]; other site 251221006738 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cd00838 251221006739 active site 251221006740 metal binding site [ion binding]; metal-binding site 251221006741 OpgC protein; Region: OpgC_C; cl00792 251221006742 ABC transporter, permease/ATP-binding protein; Region: MsbA_rel; TIGR02204 251221006743 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 251221006744 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 251221006745 Walker A/P-loop; other site 251221006746 ATP binding site [chemical binding]; other site 251221006747 Q-loop/lid; other site 251221006748 ABC transporter signature motif; other site 251221006749 Walker B; other site 251221006750 D-loop; other site 251221006751 H-loop/switch region; other site 251221006752 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 251221006753 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 251221006754 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 251221006755 Walker A/P-loop; other site 251221006756 ATP binding site [chemical binding]; other site 251221006757 Q-loop/lid; other site 251221006758 ABC transporter signature motif; other site 251221006759 Walker B; other site 251221006760 D-loop; other site 251221006761 H-loop/switch region; other site 251221006762 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 251221006763 Uncharacterized conserved protein [Function unknown]; Region: COG5642 251221006764 Protein of unknown function (DUF2384); Region: DUF2384; pfam09722 251221006765 RES domain; Region: RES; cl02411 251221006766 Bacterial protein of unknown function (DUF885); Region: DUF885; pfam05960 251221006767 Putative molybdenum carrier; Region: MoCo_carrier; pfam12694 251221006768 N-terminal ACT domain of a novel protein composed almost entirely of two tandem ACT domains; Region: ACT_Bt0572_1; cd04908 251221006769 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 251221006770 Photosystem I reaction centre subunit III; Region: PSI_PsaF; cl03627 251221006771 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 251221006772 catalytic loop [active] 251221006773 iron binding site [ion binding]; other site 251221006774 SpoVT / AbrB like domain; Region: SpoVT_AbrB; cl00877 251221006775 Fic/DOC family; Region: Fic; cl00960 251221006776 Distinct helicase family with a unique C-terminal domain including a metal-binding cysteine cluster [General function prediction only]; Region: COG1205 251221006777 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 251221006778 ATP binding site [chemical binding]; other site 251221006779 putative Mg++ binding site [ion binding]; other site 251221006780 Hydrogenase expression/synthesis hypA family; Region: HypA; pfam01155 251221006781 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 251221006782 Distinct helicase family with a unique C-terminal domain including a metal-binding cysteine cluster [General function prediction only]; Region: COG1205 251221006783 Domain of unknown function (DUF1998); Region: DUF1998; pfam09369 251221006784 Plasmid stabilisation system protein; Region: Plasmid_stabil; cl11422 251221006785 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 251221006786 DNA-dependent helicase II; Provisional; Region: uvrD; PRK11773 251221006787 N-6 DNA Methylase; Region: N6_Mtase; pfam02384 251221006788 type II restriction m6 adenine DNA methyltransferase, Alw26I/Eco31I/Esp3I family; Region: met_A_Alw26; TIGR02987 251221006789 Superfamily II DNA/RNA helicases, SNF2 family [Transcription / DNA replication, recombination, and repair]; Region: HepA; COG0553 251221006790 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 251221006791 ATP binding site [chemical binding]; other site 251221006792 putative Mg++ binding site [ion binding]; other site 251221006793 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 251221006794 nucleotide binding region [chemical binding]; other site 251221006795 ATP-binding site [chemical binding]; other site 251221006796 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 251221006797 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 251221006798 Probable transposase; Region: OrfB_IS605; pfam01385 251221006799 Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282 251221006800 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 251221006801 TPR motif; other site 251221006802 binding surface 251221006803 Antibiotic biosynthesis monooxygenase; Region: ABM; cl10022 251221006804 Phosphoribosyl transferase domain; Region: Pribosyltran; cl00309 251221006805 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 251221006806 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 251221006807 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 251221006808 synthetase active site [active] 251221006809 NTP binding site [chemical binding]; other site 251221006810 metal binding site [ion binding]; metal-binding site 251221006811 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 251221006812 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 251221006813 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 251221006814 dimer interface [polypeptide binding]; other site 251221006815 phosphorylation site [posttranslational modification] 251221006816 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 251221006817 ATP binding site [chemical binding]; other site 251221006818 Mg2+ binding site [ion binding]; other site 251221006819 G-X-G motif; other site 251221006820 Response regulator receiver domain; Region: Response_reg; pfam00072 251221006821 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 251221006822 active site 251221006823 phosphorylation site [posttranslational modification] 251221006824 intermolecular recognition site; other site 251221006825 dimerization interface [polypeptide binding]; other site 251221006826 PAS fold; Region: PAS_3; pfam08447 251221006827 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 251221006828 PAS fold; Region: PAS_3; pfam08447 251221006829 putative active site [active] 251221006830 heme pocket [chemical binding]; other site 251221006831 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 251221006832 dimer interface [polypeptide binding]; other site 251221006833 phosphorylation site [posttranslational modification] 251221006834 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 251221006835 ATP binding site [chemical binding]; other site 251221006836 Mg2+ binding site [ion binding]; other site 251221006837 G-X-G motif; other site 251221006838 Domain of unknown function (DUF2382); Region: DUF2382; cl01590 251221006839 Domain of unknown function (DUF2382); Region: DUF2382; cl01590 251221006840 CsbD-like; Region: CsbD; cl01888 251221006841 Integral membrane protein TerC family; Region: TerC; cl10468 251221006842 Proline dehydrogenase; Region: Pro_dh; cl03282 251221006843 1-pyrroline-5-carboxylate dehydrogenase; Provisional; Region: PRK03137 251221006844 Delta(1)-pyrroline-5-carboxylate dehydrogenase, RocA; Region: ALDH_PutA-P5CDH-RocA; cd07124 251221006845 Glutamate binding site [chemical binding]; other site 251221006846 homodimer interface [polypeptide binding]; other site 251221006847 NAD binding site [chemical binding]; other site 251221006848 catalytic residues [active] 251221006849 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cl00120 251221006850 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342 251221006851 Domain of unknown function DUF20; Region: UPF0118; cl00465 251221006852 Helix-turn-helix domains; Region: HTH; cl00088 251221006853 Protein of unknown function (DUF952); Region: DUF952; cl01393 251221006854 GTP-binding protein LepA; Provisional; Region: PRK05433 251221006855 LepA subfamily. LepA belongs to the GTPase family of and exhibits significant homology to the translation factors EF-G and EF-Tu, indicating its possible involvement in translation and association with the ribosome. LepA is ubiquitous in bacteria and...; Region: LepA; cd01890 251221006856 G1 box; other site 251221006857 putative GEF interaction site [polypeptide binding]; other site 251221006858 GTP/Mg2+ binding site [chemical binding]; other site 251221006859 Switch I region; other site 251221006860 G2 box; other site 251221006861 G3 box; other site 251221006862 Switch II region; other site 251221006863 G4 box; other site 251221006864 G5 box; other site 251221006865 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 251221006866 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 251221006867 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 251221006868 SGNH_hydrolase subfamily, similar to Ruminococcus flavefaciens XynB. Most likely a secreted hydrolase with xylanase activity. SGNH hydrolases are a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from...; Region: XynB_like; cd01833 251221006869 active site 251221006870 catalytic triad [active] 251221006871 oxyanion hole [active] 251221006872 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 251221006873 Protein of unknown function (DUF3037); Region: DUF3037; pfam11236 251221006874 HipA-like N-terminal domain; Region: HipA_N; pfam07805 251221006875 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; cl15394 251221006876 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 251221006877 active site 251221006878 metal binding site [ion binding]; metal-binding site 251221006879 catalase/hydroperoxidase HPI(I); Provisional; Region: PRK15061 251221006880 N-terminal catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_1; cd00649 251221006881 dimer interface [polypeptide binding]; other site 251221006882 active site 251221006883 heme binding site [chemical binding]; other site 251221006884 C-terminal non-catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_2; cd08200 251221006885 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity. They also contain a...; Region: Nudix_Hydrolase_1; cd03674 251221006886 nudix motif; other site 251221006887 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 251221006888 binding surface 251221006889 TPR motif; other site 251221006890 Lignostilbene-alpha,beta-dioxygenase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3670 251221006891 Retinal pigment epithelial membrane protein; Region: RPE65; cl10080 251221006892 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 251221006893 putative FeS-containing Cyanobacterial-specific oxidoreductase; Region: cyano_FeS_chp; TIGR03279 251221006894 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 251221006895 FeS/SAM binding site; other site 251221006896 Protein of unknown function (DUF512); Region: DUF512; pfam04459 251221006897 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 251221006898 Protein of unknown function (DUF3153); Region: DUF3153; pfam11353 251221006899 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 251221006900 S-adenosylmethionine binding site [chemical binding]; other site 251221006901 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 251221006902 Ligand binding site; other site 251221006903 Putative Catalytic site; other site 251221006904 DXD motif; other site 251221006905 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 251221006906 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 251221006907 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087 251221006908 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 251221006909 Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561 251221006910 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 251221006911 active site 251221006912 motif I; other site 251221006913 motif II; other site 251221006914 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 251221006915 putative active site [active] 251221006916 Cytochrome c; Region: Cytochrom_C; cl11414 251221006917 Cytochrome c; Region: Cytochrom_C; cl11414 251221006918 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 251221006919 Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062 251221006920 substrate binding pocket [chemical binding]; other site 251221006921 membrane-bound complex binding site; other site 251221006922 hinge residues; other site 251221006923 ribosomal protein L20; Region: rpl20; CHL00068 251221006924 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 251221006925 23S rRNA binding site [nucleotide binding]; other site 251221006926 L21 binding site [polypeptide binding]; other site 251221006927 L13 binding site [polypeptide binding]; other site 251221006928 Ribosomal protein L35; Region: Ribosomal_L35p; cl00392 251221006929 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 251221006930 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 251221006931 Aminopeptidase N [Amino acid transport and metabolism]; Region: PepN; COG0308 251221006932 Peptidase M1 family Aminopeptidase N; Region: M1_APN_4; cd09603 251221006933 Zn binding site [ion binding]; other site 251221006934 Phosphoribosyl transferase domain; Region: Pribosyltran; cl00309 251221006935 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 251221006936 substrate binding site; other site 251221006937 dimer interface; other site 251221006938 Domain of unknown function (DUF1995); Region: DUF1995; pfam09353 251221006939 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 251221006940 putative active site [active] 251221006941 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 251221006942 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 251221006943 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 251221006944 Lipopolysaccharide-assembly, LptC-related; Region: LptC; pfam06835 251221006945 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 251221006946 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 251221006947 active site 251221006948 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 251221006949 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 251221006950 active site 251221006951 phosphorylation site [posttranslational modification] 251221006952 intermolecular recognition site; other site 251221006953 dimerization interface [polypeptide binding]; other site 251221006954 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 251221006955 DNA binding site [nucleotide binding] 251221006956 global nitrogen regulator NtcA, cyanobacterial; Region: NtcA_cyano; TIGR03697 251221006957 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 251221006958 putative switch regulator; other site 251221006959 non-specific DNA interactions [nucleotide binding]; other site 251221006960 DNA binding site [nucleotide binding] 251221006961 sequence specific DNA binding site [nucleotide binding]; other site 251221006962 putative cAMP binding site [chemical binding]; other site 251221006963 Alpha amylase catalytic domain found in an uncharacterized protein family; Region: AmyAc_1; cd11347 251221006964 active site 251221006965 catalytic site [active] 251221006966 Domain of unknown function (DUF4415); Region: DUF4415; cl01401 251221006967 acetolactate synthase; Reviewed; Region: PRK08322 251221006968 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 251221006969 PYR/PP interface [polypeptide binding]; other site 251221006970 dimer interface [polypeptide binding]; other site 251221006971 TPP binding site [chemical binding]; other site 251221006972 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; cl00815 251221006973 Thiamine pyrophosphate (TPP) family, Acetolactate synthase (ALS) subfamily, TPP-binding module; composed of proteins similar to Klebsiella pneumoniae ALS, a catabolic enzyme required for butanediol fermentation. ALS catalyzes the conversion of 2...; Region: TPP_ALS; cd02010 251221006974 TPP-binding site [chemical binding]; other site 251221006975 dimer interface [polypeptide binding]; other site 251221006976 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 251221006977 Mycobacterium tuberculosis succinate-semialdehyde dehydrogenase 1-like; Region: ALDH_SSADH1_GabD1; cd07100 251221006978 NAD(P) binding site [chemical binding]; other site 251221006979 catalytic residues [active] 251221006980 Phycobilisome Linker polypeptide; Region: PBS_linker_poly; pfam00427 251221006981 Phycobilisome Linker polypeptide; Region: PBS_linker_poly; pfam00427 251221006982 Phycobilisome Linker polypeptide; Region: PBS_linker_poly; pfam00427 251221006983 tellurium resistance terB-like protein; Region: terB_like; cd07177 251221006984 metal binding site [ion binding]; metal-binding site 251221006985 Mo-dependent nitrogenase C-terminus; Region: Mo-nitro_C; pfam06967 251221006986 alpha/beta hydrolase fold protein; Provisional; Region: PLN03084 251221006987 Gluconolactonase [Carbohydrate transport and metabolism]; Region: COG3386 251221006988 Strictosidine synthase; Region: Str_synth; pfam03088 251221006989 Elongation factor G (EF-G) subfamily. Translocation is mediated by EF-G (also called translocase). The structure of EF-G closely resembles that of the complex between EF-Tu and tRNA. This is an example of molecular mimicry; a protein domain evolved so...; Region: EF-G_bact; cd04170 251221006990 elongation factor G; Reviewed; Region: PRK12740 251221006991 G1 box; other site 251221006992 putative GEF interaction site [polypeptide binding]; other site 251221006993 GTP/Mg2+ binding site [chemical binding]; other site 251221006994 Switch I region; other site 251221006995 G2 box; other site 251221006996 G3 box; other site 251221006997 Switch II region; other site 251221006998 G4 box; other site 251221006999 G5 box; other site 251221007000 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 251221007001 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 251221007002 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 251221007003 A type 1 glutamine amidotransferase (GATase1)-like domain found in PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_like; cd03134 251221007004 proposed catalytic triad [active] 251221007005 conserved cys residue [active] 251221007006 AbrB-like transcriptional regulator; Region: AbrB-like; pfam14250 251221007007 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 251221007008 S-adenosylmethionine binding site [chemical binding]; other site 251221007009 Cupin domain; Region: Cupin_2; cl09118 251221007010 Gluconate kinase (GntK) catalyzes the phosphoryl transfer from ATP to gluconate. The resulting product gluconate-6-phoshate is an important precursor of gluconate metabolism. GntK acts as a dimmer composed of two identical subunits; Region: GntK; cd02021 251221007011 Gluconate kinase [Carbohydrate transport and metabolism]; Region: GntK; COG3265 251221007012 ATP-binding site [chemical binding]; other site 251221007013 Gluconate-6-phosphate binding site [chemical binding]; other site 251221007014 Ferritin-like domain; Region: Ferritin; pfam00210 251221007015 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 251221007016 dimerization interface [polypeptide binding]; other site 251221007017 DPS ferroxidase diiron center [ion binding]; other site 251221007018 ion pore; other site 251221007019 UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087 251221007020 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 251221007021 NAD binding site [chemical binding]; other site 251221007022 homodimer interface [polypeptide binding]; other site 251221007023 active site 251221007024 substrate binding site [chemical binding]; other site 251221007025 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 251221007026 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 251221007027 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 251221007028 structural tetrad; other site 251221007029 FOG: WD40 repeat [General function prediction only]; Region: COG2319 251221007030 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 251221007031 structural tetrad; other site 251221007032 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 251221007033 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 251221007034 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cl11420 251221007035 Gluconolactonase [Carbohydrate transport and metabolism]; Region: COG3386 251221007036 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 251221007037 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 251221007038 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 251221007039 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 251221007040 Quinone oxidoreductase (QOR); Region: QOR1; cd08241 251221007041 NAD(P) binding site [chemical binding]; other site 251221007042 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 251221007043 FAD binding domain; Region: FAD_binding_3; pfam01494 251221007044 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011 251221007045 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 251221007046 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 251221007047 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 251221007048 active site 251221007049 Acyl transferase domain; Region: Acyl_transf_1; cl08282 251221007050 Phosphopantetheine attachment site; Region: PP-binding; cl09936 251221007051 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 251221007052 Phosphopantetheine attachment site; Region: PP-binding; cl09936 251221007053 2-Nitropropane dioxygenase (NPD)-like domain, associated with the (acyl-carrier-protein) S-malonyltransferase FabD. NPD is part of the nitroalkaneoxidizing enzyme family, that catalyzes oxidative denitrification of nitroalkanes to their corresponding...; Region: NPD_FabD; cd04742 251221007054 FMN binding site [chemical binding]; other site 251221007055 Dioxygenases related to 2-nitropropane dioxygenase [General function prediction only]; Region: COG2070 251221007056 substrate binding site [chemical binding]; other site 251221007057 putative catalytic residue [active] 251221007058 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 251221007059 active site 251221007060 Acyl transferase domain; Region: Acyl_transf_1; cl08282 251221007061 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 251221007062 3-ketoacyl-(acyl-carrier-protein) reductase; Reviewed; Region: PRK12826 251221007063 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 251221007064 NAD(P) binding site [chemical binding]; other site 251221007065 active site 251221007066 Alpha-acetolactate decarboxylase; Region: AAL_decarboxy; cl01408 251221007067 Alpha-acetolactate decarboxylase; Region: AAL_decarboxy; cl01408 251221007068 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 251221007069 Cinnamyl alcohol dehydrogenases (CAD) and related proteins; Region: CAD; cd08245 251221007070 NAD binding site [chemical binding]; other site 251221007071 substrate binding site [chemical binding]; other site 251221007072 catalytic Zn binding site [ion binding]; other site 251221007073 structural Zn binding site [ion binding]; other site 251221007074 tetramer interface [polypeptide binding]; other site 251221007075 Mo-dependent nitrogenase C-terminus; Region: Mo-nitro_C; pfam06967 251221007076 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 251221007077 classical (c) SDRs; Region: SDR_c; cd05233 251221007078 NAD(P) binding site [chemical binding]; other site 251221007079 active site 251221007080 The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915 251221007081 Protein export membrane protein; Region: SecD_SecF; cl14618 251221007082 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 251221007083 Predicted oxidoreductases (related to aryl-alcohol dehydrogenases) [Energy production and conversion]; Region: Tas; COG0667 251221007084 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 251221007085 active site 251221007086 catalytic tetrad [active] 251221007087 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_y; TIGR03182 251221007088 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 251221007089 tetramer interface [polypeptide binding]; other site 251221007090 TPP-binding site [chemical binding]; other site 251221007091 heterodimer interface [polypeptide binding]; other site 251221007092 phosphorylation loop region [posttranslational modification] 251221007093 Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919 251221007094 tetramerization interface [polypeptide binding]; other site 251221007095 active site 251221007096 pyruvate dehydrogenase E1 component beta subunit; Validated; Region: odpB; CHL00144 251221007097 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 251221007098 alpha subunit interface [polypeptide binding]; other site 251221007099 TPP binding site [chemical binding]; other site 251221007100 heterodimer interface [polypeptide binding]; other site 251221007101 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 251221007102 polyketide-type polyunsaturated fatty acid synthase PfaA; Region: omega_3_PfaA; TIGR02813 251221007103 Acyl transferase domain; Region: Acyl_transf_1; cl08282 251221007104 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 251221007105 putative NADP binding site [chemical binding]; other site 251221007106 active site 251221007107 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 251221007108 Thioesterase domain; Region: Thioesterase; pfam00975 251221007109 Phosphopantetheinyl transferase [Coenzyme metabolism]; Region: Sfp; COG2091 251221007110 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; cl00500 251221007111 'elongating' condensing enzymes are a subclass of decarboxylating condensing enzymes, including beta-ketoacyl [ACP] synthase, type I and II and polyketide synthases.They are characterized by the utlization of acyl carrier protein (ACP) thioesters as...; Region: elong_cond_enzymes; cd00828 251221007112 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 251221007113 active site 251221007114 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 251221007115 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 251221007116 dimer interface [polypeptide binding]; other site 251221007117 active site 251221007118 Phosphopantetheine attachment site; Region: PP-binding; cl09936 251221007119 Helix-turn-helix domains; Region: HTH; cl00088 251221007120 Helix-turn-helix domains; Region: HTH; cl00088 251221007121 LysR transcriptional regulator; Provisional; Region: rbcR; CHL00180 251221007122 C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420 251221007123 putative dimerization interface [polypeptide binding]; other site 251221007124 Antibiotic biosynthesis monooxygenase; Region: ABM; cl10022 251221007125 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 251221007126 classical (c) SDRs; Region: SDR_c; cd05233 251221007127 NAD(P) binding site [chemical binding]; other site 251221007128 active site 251221007129 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 251221007130 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl14614 251221007131 NAD(P) binding site [chemical binding]; other site 251221007132 LysR family transcriptional regulator; Provisional; Region: PRK14997 251221007133 Helix-turn-helix domains; Region: HTH; cl00088 251221007134 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 251221007135 putative effector binding pocket; other site 251221007136 dimerization interface [polypeptide binding]; other site 251221007137 exonuclease SbcC; Region: sbcc; TIGR00618 251221007138 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 251221007139 Walker A/P-loop; other site 251221007140 ATP binding site [chemical binding]; other site 251221007141 Q-loop/lid; other site 251221007142 Rad50 zinc hook motif; Region: Rad50_zn_hook; pfam04423 251221007143 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 251221007144 ABC transporter signature motif; other site 251221007145 Walker B; other site 251221007146 D-loop; other site 251221007147 H-loop/switch region; other site 251221007148 Helix-Turn-Helix DNA binding domain of the HspR transcription regulator; Region: HTH_HspR; cd04766 251221007149 DNA binding residues [nucleotide binding] 251221007150 putative dimer interface [polypeptide binding]; other site 251221007151 acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated; Region: PRK05724 251221007152 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cl14780 251221007153 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 251221007154 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 251221007155 The Delta9 Fatty Acid Desaturase (Delta9-FADS)-like CD includes the delta-9 and delta-11 acyl CoA desaturases found in various eukaryotes including vertebrates, insects, higher plants, and fungi. The delta-9 acyl-lipid desaturases are found in a wide...; Region: Delta9-FADS-like; cd03505 251221007156 Di-iron ligands [ion binding]; other site 251221007157 Helix-turn-helix domains; Region: HTH; cl00088 251221007158 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 251221007159 active site 251221007160 Int/Topo IB signature motif; other site 251221007161 DNA binding site [nucleotide binding] 251221007162 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 251221007163 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 251221007164 Glucan exporter ATP-binding protein. In A. tumefaciens cyclic beta-1, 2-glucan must be transported into the periplasmic space to exert its action as a virluence factor. This subfamily belongs to the MRP-like family and is involved in drug, peptide, and...; Region: ABCC_Glucan_exporter_like; cd03254 251221007165 Walker A/P-loop; other site 251221007166 ATP binding site [chemical binding]; other site 251221007167 Q-loop/lid; other site 251221007168 ABC transporter signature motif; other site 251221007169 Walker B; other site 251221007170 D-loop; other site 251221007171 H-loop/switch region; other site 251221007172 SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450 251221007173 mercuric reductase; Validated; Region: PRK06370 251221007174 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 251221007175 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 251221007176 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 251221007177 ABC-2 type transporter; Region: ABC2_membrane; cl11417 251221007178 photosystem II complex extrinsic protein precursor U; Provisional; Region: psbU; PRK02515 251221007179 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 251221007180 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 251221007181 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 251221007182 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 251221007183 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 251221007184 NifU-like domain; Region: NifU; cl00484 251221007185 Predicted NAD/FAD-dependent oxidoreductase [General function prediction only]; Region: COG3380 251221007186 Ferredoxin [Energy production and conversion]; Region: Fer; COG1141 251221007187 Protein of unknown function (DUF1257); Region: DUF1257; cl06088 251221007188 Protein of unknown function (DUF2997); Region: DUF2997; pfam11211 251221007189 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 251221007190 RuvA N terminal domain; Region: RuvA_N; pfam01330 251221007191 RuvA, C-terminal domain; Region: RuvA_C; pfam07499 251221007192 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4222 251221007193 SdiA-regulated; Region: SdiA-regulated; cl06158 251221007194 putative active site [active] 251221007195 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK12305 251221007196 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; cl08469 251221007197 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 251221007198 active site 251221007199 dimer interface [polypeptide binding]; other site 251221007200 motif 1; other site 251221007201 motif 2; other site 251221007202 motif 3; other site 251221007203 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 251221007204 anticodon binding site; other site 251221007205 Zinc-dependent metalloprotease; MMP_like sub-family 1. A group of bacterial, archaeal, and fungal metalloproteinase domains similar to matrix metalloproteinases and astacin; Region: ZnMc_MMP_like_1; cd04279 251221007206 active site 251221007207 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 251221007208 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 251221007209 Archaeal ATPase; Region: Arch_ATPase; pfam01637 251221007210 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 251221007211 FOG: WD40 repeat [General function prediction only]; Region: COG2319 251221007212 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 251221007213 structural tetrad; other site 251221007214 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 251221007215 structural tetrad; other site 251221007216 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 251221007217 Predicted transcriptional regulator [Transcription]; Region: COG2378 251221007218 Helix-turn-helix domains; Region: HTH; cl00088 251221007219 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 251221007220 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 251221007221 triphenylmethane reductase (TMR)-like proteins, NMRa-like, atypical (a) SDRs; Region: TMR_SDR_a; cd05269 251221007222 NADP binding site [chemical binding]; other site 251221007223 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 251221007224 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 251221007225 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 251221007226 RNA polymerase sigma factor SigF; Reviewed; Region: PRK07408 251221007227 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 251221007228 binding surface 251221007229 TPR motif; other site 251221007230 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 251221007231 binding surface 251221007232 TPR motif; other site 251221007233 CHAT domain; Region: CHAT; cl02083 251221007234 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 251221007235 oligomerisation interface [polypeptide binding]; other site 251221007236 mobile loop; other site 251221007237 roof hairpin; other site 251221007238 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 251221007239 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 251221007240 ring oligomerisation interface [polypeptide binding]; other site 251221007241 ATP/Mg binding site [chemical binding]; other site 251221007242 stacking interactions; other site 251221007243 hinge regions; other site 251221007244 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 251221007245 LivF (TM1139) is part of the LIV-I bacterial ABC-type two-component transport system that imports neutral, branched-chain amino acids. The E. coli branched-chain amino acid transporter comprises a heterodimer of ABC transporters (LivF and LivG), a...; Region: ABC_TM1139_LivF_branched; cd03224 251221007246 Walker A/P-loop; other site 251221007247 ATP binding site [chemical binding]; other site 251221007248 Q-loop/lid; other site 251221007249 ABC transporter signature motif; other site 251221007250 Walker B; other site 251221007251 D-loop; other site 251221007252 H-loop/switch region; other site 251221007253 PIN domain of the Rv0301 toxin of Mycobacterium tuberculosis and other uncharacterized, annotated PilT protein domain proteins; Region: PIN_MtRv0301; cd09882 251221007254 putative active site [active] 251221007255 Uncharacterized protein conserved in bacteria (DUF2191); Region: DUF2191; cl02270 251221007256 DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481 251221007257 MltA specific insert domain; Region: MltA; cl08398 251221007258 3D domain; Region: 3D; cl01439 251221007259 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 251221007260 Mechanosensitive ion channel; Region: MS_channel; pfam00924 251221007261 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 251221007262 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; cl15275 251221007263 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 251221007264 beta subunit interaction interface [polypeptide binding]; other site 251221007265 Walker A motif; other site 251221007266 ATP binding site [chemical binding]; other site 251221007267 Walker B motif; other site 251221007268 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 251221007269 F0F1-type ATP synthase, delta subunit (mitochondrial oligomycin sensitivity protein) [Energy production and conversion]; Region: AtpH; cl15360 251221007270 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 251221007271 F0F1 ATP synthase subunit B; Validated; Region: PRK07352 251221007272 Mitochondrial ATP synthase B chain precursor (ATP-synt_B); Region: Mt_ATP-synt_B; cl07975 251221007273 Mitochondrial ATP synthase B chain precursor (ATP-synt_B); Region: Mt_ATP-synt_B; cl07975 251221007274 F0F1 ATP synthase subunit B'; Validated; Region: PRK07353 251221007275 ATP synthase subunit C; Region: ATP-synt_C; cl00466 251221007276 ATP synthase A chain; Region: ATP-synt_A; cl00413 251221007277 Predicted metal-dependent phosphoesterases (PHP family) [General function prediction only]; Region: COG0613 251221007278 DNA polymerase alpha chain like domain; Region: POLIIIAc; smart00481 251221007279 KWG Leptospira; Region: KWG; pfam07656 251221007280 KWG Leptospira; Region: KWG; pfam07656 251221007281 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 251221007282 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 251221007283 active site 251221007284 HIGH motif; other site 251221007285 nucleotide binding site [chemical binding]; other site 251221007286 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 251221007287 active site 251221007288 KMSKS motif; other site 251221007289 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 251221007290 tRNA binding surface [nucleotide binding]; other site 251221007291 anticodon binding site; other site 251221007292 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 251221007293 Histidyl-tRNA synthetase; Region: PLN02972 251221007294 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl12011 251221007295 Uncharacterized conserved protein [Function unknown]; Region: COG1912 251221007296 S-adenosyl-l-methionine hydroxide adenosyltransferase; Region: SAM_adeno_trans; pfam01887 251221007297 Domain of unknown function (DUF1824); Region: DUF1824; pfam08854 251221007298 tRNA nucleotidyltransferase/poly(A) polymerase [Translation, ribosomal structure and biogenesis]; Region: PcnB; COG0617 251221007299 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 251221007300 active site 251221007301 NTP binding site [chemical binding]; other site 251221007302 metal binding triad [ion binding]; metal-binding site 251221007303 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 251221007304 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 251221007305 Zn2+ binding site [ion binding]; other site 251221007306 Mg2+ binding site [ion binding]; other site 251221007307 RRM (RNA recognition motif), also known as RBD (RNA binding domain) or RNP (ribonucleoprotein domain), is a highly abundant domain in eukaryotes found in proteins involved in post-transcriptional gene expression processes including mRNA and rRNA...; Region: RRM; cd00590 251221007308 RNA/DNA binding site [nucleotide binding]; other site 251221007309 RRM dimerization site [polypeptide binding]; other site 251221007310 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 251221007311 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 251221007312 putative tRNA-binding site [nucleotide binding]; other site 251221007313 B3/4 domain; Region: B3_4; cl11458 251221007314 tRNA synthetase B5 domain; Region: B5; cl08394 251221007315 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 251221007316 dimer interface [polypeptide binding]; other site 251221007317 motif 1; other site 251221007318 motif 3; other site 251221007319 motif 2; other site 251221007320 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; cl08386 251221007321 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl12011 251221007322 Predicted S-adenosylmethionine-dependent methyltransferase involved in cell envelope biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG0275 251221007323 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 251221007324 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 251221007325 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 251221007326 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl12011 251221007327 Protein of unknown function (DUF433); Region: DUF433; cl01030 251221007328 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 251221007329 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 251221007330 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011 251221007331 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 251221007332 L-asparaginase II; Region: Asparaginase_II; cl01842 251221007333 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4370 251221007334 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 251221007335 Uncharacterized protein involved in outer membrane biogenesis [Cell envelope biogenesis, outer membrane]; Region: AsmA; COG2982 251221007336 Family of unknown function (DUF490); Region: DUF490; pfam04357 251221007337 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 251221007338 dimer interface [polypeptide binding]; other site 251221007339 ssDNA binding site [nucleotide binding]; other site 251221007340 tetramer (dimer of dimers) interface [polypeptide binding]; other site 251221007341 Nit1, Nit 2, and related proteins, and the Nit1-like domain of NitFhit (class 10 nitrilases); Region: nit; cd07572 251221007342 Predicted amidohydrolase [General function prediction only]; Region: COG0388 251221007343 putative active site [active] 251221007344 catalytic triad [active] 251221007345 dimer interface [polypeptide binding]; other site 251221007346 succinate dehydrogenase iron-sulfur subunit; Provisional; Region: PRK12577 251221007347 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 251221007348 catalytic loop [active] 251221007349 iron binding site [ion binding]; other site 251221007350 Heterodisulfide reductase, subunit B [Energy production and conversion]; Region: HdrB; COG2048 251221007351 Cysteine-rich domain; Region: CCG; pfam02754 251221007352 Cysteine-rich domain; Region: CCG; pfam02754 251221007353 Protein of unknown function (DUF3134); Region: DUF3134; pfam11332 251221007354 Protein of unknown function (DUF2656); Region: DUF2656; pfam10847 251221007355 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 251221007356 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 251221007357 G1 box; other site 251221007358 GTP/Mg2+ binding site [chemical binding]; other site 251221007359 Superfamily I DNA and RNA helicases and helicase subunits [DNA replication, recombination, and repair]; Region: COG1112 251221007360 Plasmid stabilisation system protein; Region: Plasmid_stabil; cl11422 251221007361 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 251221007362 FeS/SAM binding site; other site 251221007363 Protein of unknown function (DUF433); Region: DUF433; cl01030 251221007364 Protein of unknown function (DUF433); Region: DUF433; cl01030 251221007365 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 251221007366 putative active site [active] 251221007367 Plasmid pRiA4b ORF-3-like protein; Region: PRiA4_ORF3; pfam07929 251221007368 Calcium binding; Region: Calci_bind_CcbP; pfam11535 251221007369 Molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: DnaK; COG0443 251221007370 Cell division ATPase FtsA [Cell division and chromosome partitioning]; Region: ftsA; COG0849 251221007371 Predicted periplasmic ligand-binding sensor domain [Signal transduction mechanisms]; Region: COG3292 251221007372 Nuclease-related domain; Region: NERD; pfam08378 251221007373 LppP/LprE lipoprotein; Region: Lipoprotein_21; pfam14041 251221007374 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 251221007375 putative active site [active] 251221007376 Protein of unknown function (DUF2993); Region: DUF2993; pfam11209 251221007377 2-phosphosulpholactate phosphatase; Region: 2-ph_phosp; cl00895 251221007378 Phosphosulfolactate phosphohydrolase and related enzymes [Coenzyme metabolism / General function prediction only]; Region: COG2045 251221007379 Peptidase family M23; Region: Peptidase_M23; pfam01551 251221007380 Helix-turn-helix domains; Region: HTH; cl00088 251221007381 Peptidase family M48; Region: Peptidase_M48; cl12018 251221007382 putative oxidoreductase/HEAT repeat-containing protein; Provisional; Region: PRK13800 251221007383 Domain of unknown function (DUF4331); Region: DUF4331; pfam14224 251221007384 HupE / UreJ protein; Region: HupE_UreJ; cl01011 251221007385 PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812 251221007386 Transposase domain (DUF772); Region: DUF772; cl12084 251221007387 Lactonase, 7-bladed beta-propeller; Region: Lactonase; pfam10282 251221007388 Helix-turn-helix domains; Region: HTH; cl00088 251221007389 DNA-binding transcriptional activator XapR; Provisional; Region: PRK09986 251221007390 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 251221007391 dimerization interface [polypeptide binding]; other site 251221007392 substrate binding pocket [chemical binding]; other site 251221007393 Small Multidrug Resistance protein; Region: Multi_Drug_Res; cl00910 251221007394 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK05945 251221007395 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 251221007396 domain; Region: Succ_DH_flav_C; pfam02910 251221007397 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 251221007398 putative active site [active] 251221007399 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 251221007400 putative active site [active] 251221007401 PhoD-like phosphatase; Region: PhoD; pfam09423 251221007402 Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389 251221007403 putative active site [active] 251221007404 putative metal binding site [ion binding]; other site 251221007405 Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389 251221007406 Uncharacterised P-loop hydrolase UPF0079; Region: UPF0079; cl00520 251221007407 YacP-like NYN domain; Region: NYN_YacP; cl01491 251221007408 Bordetella pertussis Bvg accessory factor family; Region: Bvg_acc_factor; cl09130 251221007409 Domain of unknown function (DUF4366); Region: DUF4366; pfam14283 251221007410 Bacterial pre-peptidase C-terminal domain; Region: PPC; pfam04151 251221007411 Bacterial pre-peptidase C-terminal domain; Region: PPC; pfam04151 251221007412 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 251221007413 catalytic loop [active] 251221007414 iron binding site [ion binding]; other site 251221007415 Photosystem II protein; Region: PSII; cl08223 251221007416 Photosystem II reaction centre N protein (psbN); Region: PsbN; cl03605 251221007417 Photosystem II 10 kDa phosphoprotein; Region: PsbH; cl02951 251221007418 mttA/Hcf106 family; Region: MttA_Hcf106; cl00788 251221007419 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; cl08040 251221007420 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019 251221007421 FOG: HEAT repeat [Energy production and conversion]; Region: COG1413 251221007422 PBS lyase HEAT-like repeat; Region: HEAT_PBS; cl15388 251221007423 PBS lyase HEAT-like repeat; Region: HEAT_PBS; cl15388 251221007424 RNA polymerase sigma factor, cyanobacterial RpoD-like family; Region: Sig70-cyanoRpoD; TIGR02997 251221007425 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 251221007426 putative acyl-acceptor binding pocket; other site 251221007427 3-octaprenyl-4-hydroxybenzoate carboxy-lyase; Region: UbiD; cl00311 251221007428 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 251221007429 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 251221007430 active site 251221007431 HIGH motif; other site 251221007432 dimer interface [polypeptide binding]; other site 251221007433 KMSKS motif; other site 251221007434 citrate synthase; Provisional; Region: PRK14036 251221007435 Citrate synthase (CS) catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the oxidative citric acid cycle (TCA or Krebs cycle). Peroxisomal CS is involved in the glyoxylate...; Region: citrate_synt_like_1_1; cd06112 251221007436 dimer interface [polypeptide binding]; other site 251221007437 active site 251221007438 citrylCoA binding site [chemical binding]; other site 251221007439 oxalacetate/citrate binding site [chemical binding]; other site 251221007440 coenzyme A binding site [chemical binding]; other site 251221007441 catalytic triad [active] 251221007442 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 251221007443 Cystathionine beta-lyase family protein involved in aluminum resistance [Inorganic ion transport and metabolism]; Region: COG4100 251221007444 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 251221007445 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 251221007446 catalytic residue [active] 251221007447 Competence protein J (ComJ); Region: ComJ; pfam11033 251221007448 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl14614 251221007449 NAD(P) binding site [chemical binding]; other site 251221007450 Predicted membrane-associated Zn-dependent proteases 1 [Cell envelope biogenesis, outer membrane]; Region: COG0750 251221007451 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 251221007452 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 251221007453 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 251221007454 putative substrate binding region [chemical binding]; other site 251221007455 PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812 251221007456 Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic...; Region: GST_N_family; cd00570 251221007457 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 251221007458 C-terminal domain interface [polypeptide binding]; other site 251221007459 GSH binding site (G-site) [chemical binding]; other site 251221007460 dimer interface [polypeptide binding]; other site 251221007461 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776 251221007462 N-terminal domain interface [polypeptide binding]; other site 251221007463 Predicted methyltransferases [General function prediction only]; Region: COG0313 251221007464 Tetrapyrrole (Corrin/Porphyrin) Methylases; Region: TP_methylase; cl00304 251221007465 Uncharacterized conserved protein [Function unknown]; Region: COG1432 251221007466 LabA_like proteins; Region: LabA; cd10911 251221007467 putative metal binding site [ion binding]; other site 251221007468 methionyl-tRNA synthetase; Reviewed; Region: PRK11893 251221007469 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 251221007470 active site 251221007471 HIGH motif; other site 251221007472 KMSKS motif; other site 251221007473 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 251221007474 tRNA binding surface [nucleotide binding]; other site 251221007475 anticodon binding site; other site 251221007476 molybdenum cofactor biosynthesis protein A, bacterial; Region: moaA; TIGR02666 251221007477 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 251221007478 FeS/SAM binding site; other site 251221007479 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 251221007480 Uncharacterized conserved protein [Function unknown]; Region: COG3391 251221007481 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl15700 251221007482 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl12011 251221007483 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06416 251221007484 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 251221007485 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 251221007486 Uncharacterized conserved protein [Function unknown]; Region: COG2006 251221007487 Domain of unknown function (DUF362); Region: DUF362; pfam04015 251221007488 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 251221007489 Predicted oxidoreductases (related to aryl-alcohol dehydrogenases) [Energy production and conversion]; Region: Tas; COG0667 251221007490 active site 251221007491 catalytic tetrad [active] 251221007492 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 251221007493 putative active site [active] 251221007494 Predicted acetyltransferase [General function prediction only]; Region: COG3981 251221007495 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 251221007496 Organic radical activating enzymes [Posttranslational modification, protein turnover, chaperones]; Region: NrdG; COG0602 251221007497 Domain of unknown function DUF37; Region: DUF37; cl00506 251221007498 ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995 251221007499 Ligand Binding Site [chemical binding]; other site 251221007500 cytochrome b6-f complex iron-sulfur subunit; Provisional; Region: PRK13474 251221007501 Cytochrome B6-F complex Fe-S subunit; Region: CytB6-F_Fe-S; pfam08802 251221007502 Iron-sulfur protein (ISP) component of the b6f complex family, Rieske domain; The Rieske domain is a [2Fe-2S] cluster binding domain involved in electron transfer. The cytochrome b6f complex from Mastigocladus laminosus, a thermophilic cyanobacterium; Region: Rieske_cytochrome_b6f; cd03471 251221007503 cytochrome b subunit interaction site [polypeptide binding]; other site 251221007504 [2Fe-2S] cluster binding site [ion binding]; other site 251221007505 Apocytochrome F, C-terminal; Region: Apocytochr_F_C; cl03168 251221007506 Uncharacterised protein family (UPF0093); Region: UPF0093; cl00863 251221007507 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cl00120 251221007508 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 251221007509 binding surface 251221007510 TPR motif; other site 251221007511 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 251221007512 Zinc-dependent metalloprotease; MMP_like sub-family 1. A group of bacterial, archaeal, and fungal metalloproteinase domains similar to matrix metalloproteinases and astacin; Region: ZnMc_MMP_like_1; cd04279 251221007513 active site 251221007514 PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812 251221007515 MOSC domain; Region: MOSC; pfam03473 251221007516 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 251221007517 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 251221007518 GlcNAc-PI de-N-acetylase; Region: PIG-L; cl00929 251221007519 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl12011 251221007520 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 251221007521 active site 251221007522 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 251221007523 Protein of unknown function (DUF1016); Region: DUF1016; cl01979 251221007524 Permease family; Region: Xan_ur_permease; cl00967 251221007525 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 251221007526 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 251221007527 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 251221007528 MAPEG family; Region: MAPEG; cl09190 251221007529 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 251221007530 Ribosomal protein S18; Region: Ribosomal_S18; cl00373 251221007531 Ribosomal protein L33; Region: Ribosomal_L33; cl00383 251221007532 Ammonium Transporter Family; Region: Ammonium_transp; cl03012 251221007533 Ammonium Transporter Family; Region: Ammonium_transp; cl03012 251221007534 Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; cl00398 251221007535 Putative modulator of DNA gyrase; Region: PmbA_TldD; pfam01523 251221007536 Cytochrome P450; Region: p450; cl12078 251221007537 Cytochrome P450; Region: p450; cl12078 251221007538 Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; cl00398 251221007539 Putative modulator of DNA gyrase; Region: PmbA_TldD; pfam01523 251221007540 Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332 251221007541 active sites [active] 251221007542 tetramer interface [polypeptide binding]; other site 251221007543 FAD binding domain; Region: FAD_binding_4; pfam01565 251221007544 glycolate oxidase, subunit GlcD; Region: glcD; TIGR00387 251221007545 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 251221007546 FAD binding domain; Region: FAD_binding_4; pfam01565 251221007547 glycolate oxidase iron-sulfur subunit; Provisional; Region: glcF; PRK11274 251221007548 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 251221007549 Cysteine-rich domain; Region: CCG; pfam02754 251221007550 Cysteine-rich domain; Region: CCG; pfam02754 251221007551 Phosphoketolase [Carbohydrate transport and metabolism]; Region: COG3957 251221007552 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 251221007553 TPP-binding site [chemical binding]; other site 251221007554 Pyrimidine (PYR) binding domain of thiamine pyrophosphate (TPP)-dependent enzymes; Region: TPP_enzyme_PYR; cl11410 251221007555 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 251221007556 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 251221007557 DNA binding residues [nucleotide binding] 251221007558 dimerization interface [polypeptide binding]; other site 251221007559 cobaltochelatase subunit CobN; Reviewed; Region: cobN; PRK05989 251221007560 CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150 251221007561 CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150 251221007562 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 251221007563 putative active site [active] 251221007564 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 251221007565 Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738 251221007566 quinone interaction residues [chemical binding]; other site 251221007567 Dihydroorotate dehydrogenase [Nucleotide transport and metabolism]; Region: PyrD; COG0167 251221007568 active site 251221007569 catalytic residues [active] 251221007570 FMN binding site [chemical binding]; other site 251221007571 substrate binding site [chemical binding]; other site 251221007572 MOSC N-terminal beta barrel domain; Region: MOSC_N; pfam03476 251221007573 Uncharacterized Fe-S protein [General function prediction only]; Region: COG3217 251221007574 MOSC domain; Region: MOSC; pfam03473 251221007575 DNA gyrase subunit A; Validated; Region: PRK05560 251221007576 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes in DNA...; Region: TOP4c; cd00187 251221007577 CAP-like domain; other site 251221007578 active site 251221007579 primary dimer interface [polypeptide binding]; other site 251221007580 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 251221007581 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 251221007582 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 251221007583 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 251221007584 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 251221007585 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 251221007586 NTP_transferases catalyze the transfer of nucleotides onto phosphosugars; Region: NTP_transferase; cd04181 251221007587 active site 251221007588 Substrate binding site; other site 251221007589 Mg++ binding site; other site 251221007590 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 251221007591 coproporphyrinogen III oxidase; Provisional; Region: PRK07379 251221007592 HemN C-terminal region; Region: HemN_C; pfam06969 251221007593 Integral membrane protein (PIN domain superfamily) [General function prediction only]; Region: COG4956 251221007594 PIN domain of Thermus Thermophilus Hb8, uncharacterized Bacillus subtilis YacL, and other bacterial homologs; Region: PIN_YacL; cd09877 251221007595 putative active site [active] 251221007596 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 251221007597 active site 251221007598 catalytic residues [active] 251221007599 PA_subtilisin_1: Protease-associated domain containing subtilisin-like proteases, subgroup 1. A subgroup of PA domain-containing subtilisin-like proteases. The significance of the PA domain to many of the proteins in which it is inserted is undetermined; Region: PA_subtilisin_1; cd04818 251221007600 PA/protease or protease-like domain interface [polypeptide binding]; other site 251221007601 Peptidase S8 family domain in Vpr-like proteins; Region: Peptidases_S8_subtilisin_Vpr-like; cd07474 251221007602 Fn3-like domain (DUF1034); Region: DUF1034; pfam06280 251221007603 Isocitrate/isopropylmalate dehydrogenase; Region: Iso_dh; cl00445 251221007604 isocitrate dehydrogenase; Validated; Region: PRK06451 251221007605 tocopherol cyclase; Region: PLN02818 251221007606 tocopherol O-methyltransferase; Region: PLN02244 251221007607 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 251221007608 S-adenosylmethionine binding site [chemical binding]; other site 251221007609 4-hydroxyphenylpyruvate dioxygenase; Region: 4HPPD; TIGR01263 251221007610 N-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HPPD) and hydroxymandelate Synthase (HmaS); Region: HPPD_N_like; cd08342 251221007611 dimer interface [polypeptide binding]; other site 251221007612 C-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HppD) and hydroxymandelate Synthase (HmaS); Region: HPPD_C_like; cd07250 251221007613 active site 251221007614 Fe binding site [ion binding]; other site 251221007615 PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812 251221007616 putative active site [active] 251221007617 Protein of unknown function (DUF1257); Region: DUF1257; cl06088 251221007618 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 251221007619 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 251221007620 L-Ala-D/L-Glu epimerase catalyzes the epimerization of L-Ala-D/L-Glu and other dipeptides. The genomic context and the substrate specificity of characterized members of this family from E.coli and B.subtilis indicates a possible role in the metabolism of...; Region: L-Ala-DL-Glu_epimerase; cd03319 251221007621 active site 251221007622 Protein of unknown function (DUF1611); Region: DUF1611; pfam07755 251221007623 ornithine carbamoyltransferase; Provisional; Region: PRK00779 251221007624 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 251221007625 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 251221007626 C-terminal processing peptidase family S41; Region: Peptidase_S41; cd06567 251221007627 C-terminal peptidase (prc); Region: prc; TIGR00225 251221007628 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 251221007629 protein binding site [polypeptide binding]; other site 251221007630 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 251221007631 Catalytic dyad [active] 251221007632 Outer membrane cobalamin receptor protein [Coenzyme metabolism]; Region: BtuB; COG4206 251221007633 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 251221007634 N-terminal plug; other site 251221007635 ligand-binding site [chemical binding]; other site 251221007636 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 251221007637 This family of ATP-binding proteins belongs to a multisubunit transporter involved in drug resistance (BcrA and DrrA), nodulation, lipid transport, and lantibiotic immunity. In bacteria and archaea, these transporters usually include an ATP-binding...; Region: ABC_DR_subfamily_A; cd03230 251221007638 Walker A/P-loop; other site 251221007639 ATP binding site [chemical binding]; other site 251221007640 Q-loop/lid; other site 251221007641 ABC transporter signature motif; other site 251221007642 Walker B; other site 251221007643 D-loop; other site 251221007644 H-loop/switch region; other site 251221007645 Domain of unknown function (DUF3526); Region: DUF3526; pfam12040 251221007646 ABC-2 type transporter; Region: ABC2_membrane; cl11417 251221007647 Domain of unknown function (DUF3526); Region: DUF3526; pfam12040 251221007648 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 251221007649 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl15260 251221007650 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 251221007651 active site residue [active] 251221007652 Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron transport...; Region: FNR_like; cd00322 251221007653 FAD binding pocket [chemical binding]; other site 251221007654 conserved FAD binding motif [chemical binding]; other site 251221007655 phosphate binding motif [ion binding]; other site 251221007656 beta-alpha-beta structure motif; other site 251221007657 NAD binding pocket [chemical binding]; other site 251221007658 lipopolysaccharide core biosynthesis protein; Provisional; Region: PRK10422 251221007659 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 251221007660 putative active site [active] 251221007661 2TM domain; Region: 2TM; pfam13239 251221007662 chaperone protein DnaJ; Provisional; Region: PRK10767 251221007663 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 251221007664 HSP70 interaction site [polypeptide binding]; other site 251221007665 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 251221007666 substrate binding site [polypeptide binding]; other site 251221007667 dimer interface [polypeptide binding]; other site 251221007668 Uncharacterized protein conserved in bacteria (DUF2256); Region: DUF2256; cl01792 251221007669 hypothetical protein; Provisional; Region: PRK08912 251221007670 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 251221007671 pyridoxal 5'-phosphate binding site [chemical binding]; other site 251221007672 homodimer interface [polypeptide binding]; other site 251221007673 catalytic residue [active] 251221007674 Domain of unknown function (DUF4327); Region: DUF4327; pfam14217 251221007675 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 251221007676 putative active site [active] 251221007677 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 251221007678 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 251221007679 Walker A motif; other site 251221007680 ATP binding site [chemical binding]; other site 251221007681 Walker B motif; other site 251221007682 arginine finger; other site 251221007683 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 251221007684 NAD(P)H-quinone oxidoreductase subunit 2; Provisional; Region: PRK02504 251221007685 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; cl14187 251221007686 dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254 251221007687 dTDP-4-dehydrorhamnose reductase [Cell envelope biogenesis, outer membrane]; Region: RfbD; COG1091 251221007688 NADP binding site [chemical binding]; other site 251221007689 active site 251221007690 putative substrate binding site [chemical binding]; other site 251221007691 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 251221007692 active site 251221007693 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 251221007694 phosphorylation site [posttranslational modification] 251221007695 intermolecular recognition site; other site 251221007696 dimerization interface [polypeptide binding]; other site 251221007697 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080 251221007698 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 251221007699 ATP binding site [chemical binding]; other site 251221007700 Mg2+ binding site [ion binding]; other site 251221007701 G-X-G motif; other site 251221007702 ribonuclease D; Region: rnd; TIGR01388 251221007703 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: APH_ChoK_like; cl15691 251221007704 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 251221007705 3-phosphoshikimate 1-carboxyvinyltransferase; Region: aroA; TIGR01356 251221007706 hinge; other site 251221007707 active site 251221007708 Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as Transcription factor ImmunoGlobin (TIG) domains. They are present in intracellular transcription factors, cell surface receptors (such as plexins and scatter factor...; Region: IPT; cd00102 251221007709 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 251221007710 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 251221007711 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 251221007712 dimer interface [polypeptide binding]; other site 251221007713 motif 1; other site 251221007714 active site 251221007715 motif 2; other site 251221007716 motif 3; other site 251221007717 Fructose-1,6-bisphosphatase, an enzyme that catalyzes the hydrolysis of fructose-1,6-biphosphate into fructose-6-phosphate and is critical in gluconeogenesis pathway. The alignment model also includes chloroplastic FBPases and sedoheptulose-1; Region: FBPase; cd00354 251221007718 AMP binding site [chemical binding]; other site 251221007719 metal binding site [ion binding]; metal-binding site 251221007720 active site 251221007721 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cl01898 251221007722 Phd_YefM; Region: PhdYeFM; cl09153 251221007723 Plasmid stabilisation system protein; Region: Plasmid_stabil; cl11422 251221007724 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 251221007725 Walker A motif; other site 251221007726 ATP binding site [chemical binding]; other site 251221007727 Walker B motif; other site 251221007728 TRAM domain; Region: TRAM; cl01282 251221007729 23S rRNA (uracil-5-)-methyltransferase RumA; Region: rumA; TIGR00479 251221007730 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 251221007731 S-adenosylmethionine binding site [chemical binding]; other site 251221007732 Protein of unknown function (DUF2839); Region: DUF2839; pfam10999 251221007733 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 251221007734 putative active site [active] 251221007735 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 251221007736 dimer interface [polypeptide binding]; other site 251221007737 phosphorylation site [posttranslational modification] 251221007738 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 251221007739 ATP binding site [chemical binding]; other site 251221007740 Mg2+ binding site [ion binding]; other site 251221007741 G-X-G motif; other site 251221007742 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 251221007743 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 251221007744 active site 251221007745 phosphorylation site [posttranslational modification] 251221007746 intermolecular recognition site; other site 251221007747 dimerization interface [polypeptide binding]; other site 251221007748 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 251221007749 DNA binding site [nucleotide binding] 251221007750 FtsH Extracellular; Region: FtsH_ext; pfam06480 251221007751 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 251221007752 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 251221007753 Walker A motif; other site 251221007754 ATP binding site [chemical binding]; other site 251221007755 Walker B motif; other site 251221007756 arginine finger; other site 251221007757 Peptidase family M41; Region: Peptidase_M41; pfam01434 251221007758 putative acetyltransferase; Provisional; Region: PRK03624 251221007759 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 251221007760 Coenzyme A binding pocket [chemical binding]; other site 251221007761 Angiotensin-converting enzyme; Region: Peptidase_M2; pfam01401 251221007762 Peptidase family M2 Angiotensin converting enzyme (ACE); Region: M2_ACE; cd06461 251221007763 active site 251221007764 Zn binding site [ion binding]; other site 251221007765 D1, D2 subunits of photosystem II (PSII); M, L subunits of bacterial photosynthetic reaction center; Region: Photo_RC; cl08220 251221007766 pheophytin binding site; other site 251221007767 chlorophyll binding site; other site 251221007768 quinone binding site; other site 251221007769 Fe binding site [ion binding]; other site 251221007770 long-chain fatty acyl-ACP reductase (aldehyde-forming); Region: AcACP_reductase; TIGR04058 251221007771 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 251221007772 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657 251221007773 dinuclear metal binding motif [ion binding]; other site 251221007774 Cytidylyltransferase family; Region: CTP_transf_1; cl00347 251221007775 polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824 251221007776 3' exoribonuclease family, domain 1; Region: RNase_PH; pfam01138 251221007777 3' exoribonuclease family, domain 2; Region: RNase_PH_C; pfam03725 251221007778 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 251221007779 3' exoribonuclease family, domain 1; Region: RNase_PH; pfam01138 251221007780 3' exoribonuclease family, domain 2; Region: RNase_PH_C; pfam03725 251221007781 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 251221007782 putative nucleic acid binding region [nucleotide binding]; other site 251221007783 G-X-X-G motif; other site 251221007784 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 251221007785 RNA binding site [nucleotide binding]; other site 251221007786 domain interface; other site 251221007787 TM2 domain; Region: TM2; cl00984 251221007788 Helix-hairpin-helix motif; Region: HHH_3; pfam12836 251221007789 DNA uptake protein and related DNA-binding proteins [DNA replication, recombination, and repair]; Region: ComEA; COG1555 251221007790 Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; cl00398 251221007791 Putative modulator of DNA gyrase; Region: PmbA_TldD; pfam01523 251221007792 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 251221007793 phosphopeptide binding site; other site 251221007794 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 251221007795 catalytic core [active] 251221007796 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 251221007797 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 251221007798 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 251221007799 dimer interface [polypeptide binding]; other site 251221007800 decamer (pentamer of dimers) interface [polypeptide binding]; other site 251221007801 catalytic triad [active] 251221007802 peroxidatic and resolving cysteines [active] 251221007803 peptide chain release factor 3; Provisional; Region: prfC; PRK00741 251221007804 RF3 subfamily. Peptide chain release factor 3 (RF3) is a protein involved in the termination step of translation in bacteria. Termination occurs when class I release factors (RF1 or RF2) recognize the stop codon at the A-site of the ribosome and...; Region: RF3; cd04169 251221007805 G1 box; other site 251221007806 putative GEF interaction site [polypeptide binding]; other site 251221007807 GTP/Mg2+ binding site [chemical binding]; other site 251221007808 Switch I region; other site 251221007809 G2 box; other site 251221007810 G3 box; other site 251221007811 Switch II region; other site 251221007812 G4 box; other site 251221007813 G5 box; other site 251221007814 RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689 251221007815 Peptidase domain in the S53 family; Region: Peptidases_S53_like; cd05562 251221007816 putative active site [active] 251221007817 putative catalytic triad [active] 251221007818 Bacterial pre-peptidase C-terminal domain; Region: PPC; pfam04151 251221007819 Peptidase domain in the S53 family; Region: Peptidases_S53_like; cd05562 251221007820 Peptidase domain in the S53 family; Region: Peptidases_S53_like; cd05562 251221007821 putative active site [active] 251221007822 putative catalytic triad [active] 251221007823 Bacterial pre-peptidase C-terminal domain; Region: PPC; pfam04151 251221007824 Peptidase domain in the S53 family; Region: Peptidases_S53_like; cd05562 251221007825 Acyl-protein synthetase, LuxE; Region: LuxE; cl15695 251221007826 Heme oxygenase catalyzes the rate limiting step in the degradation of heme to bilirubin, it is essential for recycling of iron from heme. Heme is used as a substrate and cofactor for its own degradation to biliverdin, iron, and carbon monoxide. This...; Region: HemeO; cl15243 251221007827 This family is most closely related to the GT1 family of glycosyltransferases. aviGT4 in Streptomyces viridochromogenes has been shown to be involved in biosynthesis of oligosaccharide antibiotic avilamycin A. Inactivation of aviGT4 resulted in a mutant...; Region: GT1_AviGT4_like; cd03802 251221007828 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 251221007829 putative ADP-binding pocket [chemical binding]; other site 251221007830 Glycogen debranching enzyme [Carbohydrate transport and metabolism]; Region: GDB1; COG3408 251221007831 Bacterial alpha-L-rhamnosidase; Region: Bac_rhamnosid; cl01801 251221007832 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 251221007833 binding surface 251221007834 TPR motif; other site 251221007835 Dehydratase family; Region: ILVD_EDD; cl00340 251221007836 Kelch motif; Region: Kelch_1; cl02701 251221007837 Kelch motif; Region: Kelch_1; cl02701 251221007838 Kelch motif; Region: Kelch_1; cl02701 251221007839 Kelch motif; Region: Kelch_1; cl02701 251221007840 Kelch motif; Region: Kelch_1; cl02701 251221007841 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 251221007842 Helix-turn-helix domains; Region: HTH; cl00088 251221007843 Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228 251221007844 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 251221007845 active site 251221007846 Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379 251221007847 Transglutaminase-like superfamily; Region: Transglut_core; cl10469 251221007848 Phosphotransferase enzyme family; Region: APH; pfam01636 251221007849 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: APH_ChoK_like; cd05120 251221007850 active site 251221007851 ATP binding site [chemical binding]; other site 251221007852 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: APH_ChoK_like; cl15691 251221007853 Low molecular weight phosphatase family; Region: LMWPc; cd00115 251221007854 active site 251221007855 CAAX amino terminal protease self- immunity; Region: Abi; cl00558 251221007856 beta-phosphoglucomutase family hydrolase; Region: PGMB-YQAB-SF; TIGR02009 251221007857 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 251221007858 motif II; other site 251221007859 hypothetical protein; Provisional; Region: PRK13683 251221007860 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 251221007861 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 251221007862 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 251221007863 Glucose-6-phosphate dehydrogenase subunit; Region: OpcA_G6PD_assem; cl01359 251221007864 6PGL: 6-Phosphogluconolactonase (6PGL) subfamily; 6PGL catalyzes the second step of the oxidative phase of the pentose phosphate pathway, the hydrolyzation of 6-phosphoglucono-1,5-lactone (delta form) to 6-phosphogluconate. 6PGL is thought to guard...; Region: 6PGL; cd01400 251221007865 putative active site [active] 251221007866 Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189 251221007867 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 251221007868 RNA binding surface [nucleotide binding]; other site 251221007869 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl12011 251221007870 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 251221007871 catalytic loop [active] 251221007872 iron binding site [ion binding]; other site 251221007873 S-adenosyl-L-homocysteine hydrolase; Provisional; Region: PRK05476 251221007874 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 251221007875 oligomerization interface [polypeptide binding]; other site 251221007876 active site 251221007877 NAD+ binding site [chemical binding]; other site 251221007878 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl12011 251221007879 Fic family protein [Function unknown]; Region: COG3177 251221007880 Fic/DOC family; Region: Fic; cl00960 251221007881 Fic/DOC family; Region: Fic; cl00960 251221007882 hypothetical protein; Provisional; Region: PRK12705 251221007883 secreted effector protein PipB2; Provisional; Region: PRK15196 251221007884 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 251221007885 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 251221007886 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 251221007887 Predicted domain in sensory proteins (DUF2308); Region: DUF2308; cl01731 251221007888 c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206 251221007889 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 251221007890 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 251221007891 active site 251221007892 metal binding site [ion binding]; metal-binding site 251221007893 MarC family integral membrane protein; Region: MarC; cl00919 251221007894 DNA topoisomerase I; Validated; Region: PRK05582 251221007895 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 251221007896 active site 251221007897 interdomain interaction site; other site 251221007898 putative metal-binding site [ion binding]; other site 251221007899 nucleotide binding site [chemical binding]; other site 251221007900 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 251221007901 domain I; other site 251221007902 DNA binding groove [nucleotide binding] 251221007903 phosphate binding site [ion binding]; other site 251221007904 domain II; other site 251221007905 domain III; other site 251221007906 nucleotide binding site [chemical binding]; other site 251221007907 catalytic site [active] 251221007908 domain IV; other site 251221007909 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 251221007910 Zinc finger domain containing protein (CHY type) [Function unknown]; Region: COG4357 251221007911 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 251221007912 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 251221007913 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 251221007914 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 251221007915 putative active site [active] 251221007916 Uncharacterized conserved protein [Function unknown]; Region: COG3391 251221007917 Phosphoesterase family; Region: Phosphoesterase; cl15450 251221007918 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: APH_ChoK_like; cl15691 251221007919 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_4; cd08500 251221007920 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 251221007921 DNA polymerase III subunits gamma and tau; Provisional; Region: PRK12323 251221007922 cyclically-permuted mutatrotase family protein; Region: mutarot_permut; TIGR03548 251221007923 Kelch motif; Region: Kelch_1; cl02701 251221007924 Kelch motif; Region: Kelch_1; cl02701 251221007925 Kelch motif; Region: Kelch_1; cl02701 251221007926 Kelch motif; Region: Kelch_1; cl02701 251221007927 Kelch motif; Region: Kelch_1; cl02701 251221007928 Kelch motif; Region: Kelch_1; cl02701 251221007929 Kelch motif; Region: Kelch_1; cl02701 251221007930 Kelch motif; Region: Kelch_1; cl02701 251221007931 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 251221007932 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 251221007933 Domain of unknown function (DUF1802); Region: DUF1802; cl01755 251221007934 GTP-binding protein Der; Reviewed; Region: PRK00093 251221007935 EngA1 subfamily. This CD represents the first GTPase domain of EngA and its orthologs, which are composed of two adjacent GTPase domains. Since the sequences of the two domains are more similar to each other than to other GTPases, it is likely that an...; Region: EngA1; cd01894 251221007936 G1 box; other site 251221007937 GTP/Mg2+ binding site [chemical binding]; other site 251221007938 Switch I region; other site 251221007939 G2 box; other site 251221007940 Switch II region; other site 251221007941 G3 box; other site 251221007942 G4 box; other site 251221007943 G5 box; other site 251221007944 EngA2 subfamily. This CD represents the second GTPase domain of EngA and its orthologs, which are composed of two adjacent GTPase domains. Since the sequences of the two domains are more similar to each other than to other GTPases, it is likely that an...; Region: EngA2; cd01895 251221007945 G1 box; other site 251221007946 GTP/Mg2+ binding site [chemical binding]; other site 251221007947 Switch I region; other site 251221007948 G2 box; other site 251221007949 G3 box; other site 251221007950 Switch II region; other site 251221007951 G4 box; other site 251221007952 G5 box; other site 251221007953 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 251221007954 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 251221007955 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 251221007956 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cd00494 251221007957 domain interfaces; other site 251221007958 active site 251221007959 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 251221007960 Catalytic site [active] 251221007961 Phycobilisome protein; Region: Phycobilisome; cl08227 251221007962 Phycobilisome protein; Region: Phycobilisome; cl08227 251221007963 Phycobilisome Linker polypeptide; Region: PBS_linker_poly; pfam00427 251221007964 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 251221007965 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 251221007966 Coenzyme A binding pocket [chemical binding]; other site 251221007967 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 251221007968 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 251221007969 Rv0623-like transcription factor; Region: PSK_trans_fac; cl01834 251221007970 PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812 251221007971 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 251221007972 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 251221007973 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 251221007974 diacylglycerol glucosyltransferase; Provisional; Region: PRK13609 251221007975 Monogalactosyldiacylglycerol (MGDG) synthase; Region: MGDG_synth; pfam06925 251221007976 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 251221007977 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 251221007978 FG-GAP repeat; Region: FG-GAP; cl15299 251221007979 DNA polymerase III subunit beta; Validated; Region: PRK05643 251221007980 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 251221007981 putative DNA binding surface [nucleotide binding]; other site 251221007982 dimer interface [polypeptide binding]; other site 251221007983 beta-clamp/clamp loader binding surface; other site 251221007984 beta-clamp/translesion DNA polymerase binding surface; other site 251221007985 GTP-binding protein YchF; Reviewed; Region: PRK09601 251221007986 YchF subfamily. YchF is a member of the Obg family, which includes four other subfamilies of GTPases: Obg, DRG, Ygr210, and NOG1. Obg is an essential gene that is involved in DNA replication in C. crescentus and Streptomyces griseus and is associated...; Region: YchF; cd01900 251221007987 G1 box; other site 251221007988 GTP/Mg2+ binding site [chemical binding]; other site 251221007989 Switch I region; other site 251221007990 G2 box; other site 251221007991 Switch II region; other site 251221007992 G3 box; other site 251221007993 G4 box; other site 251221007994 G5 box; other site 251221007995 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 251221007996 RmlD substrate binding domain; Region: RmlD_sub_bind; pfam04321 251221007997 dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254 251221007998 NADP binding site [chemical binding]; other site 251221007999 active site 251221008000 putative substrate binding site [chemical binding]; other site 251221008001 dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088 251221008002 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 251221008003 NAD binding site [chemical binding]; other site 251221008004 substrate binding site [chemical binding]; other site 251221008005 homodimer interface [polypeptide binding]; other site 251221008006 active site 251221008007 Bacterial sugar transferase; Region: Bac_transf; cl00939 251221008008 G1P_TT_long represents the long form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_long; cd04189 251221008009 glucose-1-phosphate thymidylylransferase, long form; Region: rmlA_long; TIGR01208 251221008010 substrate binding site; other site 251221008011 metal-binding site 251221008012 Oligomer interface; other site 251221008013 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 251221008014 Periplasmic protein involved in polysaccharide export, contains SLBB domain of b-grasp fold [Cell wall/membrane/envelope biogenesis]; Region: Wza; COG1596 251221008015 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 251221008016 putative polysaccharide export protein, PEP-CTERM sytem-associated; Region: pepcterm_export; TIGR03027 251221008017 SLBB domain; Region: SLBB; pfam10531 251221008018 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 251221008019 binding surface 251221008020 TPR motif; other site 251221008021 putative PEP-CTERM system TPR-repeat lipoprotein; Region: PEP_TPR_lipo; TIGR02917 251221008022 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 251221008023 TPR motif; other site 251221008024 binding surface 251221008025 PHP domain; Region: PHP; pfam02811 251221008026 Protein of unknown function (DUF3007); Region: DUF3007; pfam11460 251221008027 Protein of unknown function (DUF2945); Region: DUF2945; pfam11160 251221008028 Protein of unknown function (DUF3140); Region: DUF3140; pfam11338 251221008029 Predicted outer membrane protein [Function unknown]; Region: COG3652 251221008030 IPP transferase; Region: IPPT; cl00403 251221008031 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 251221008032 Domain of unknown function (DUF1995); Region: DUF1995; pfam09353 251221008033 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cl01898 251221008034 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 251221008035 P-loop; other site 251221008036 Magnesium ion binding site [ion binding]; other site 251221008037 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 251221008038 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293 251221008039 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293 251221008040 Protein of unknown function, DUF393; Region: DUF393; cl01136 251221008041 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 251221008042 putative active site [active] 251221008043 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 251221008044 active site 251221008045 Ycf39; Provisional; Region: ycf39; CHL00194 251221008046 atypical (a) SDRs, subgroup 5; Region: SDR_a5; cd05243 251221008047 NAD(P) binding site [chemical binding]; other site 251221008048 putative active site [active] 251221008049 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149 251221008050 Ycf46; Provisional; Region: ycf46; CHL00195 251221008051 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 251221008052 Walker A motif; other site 251221008053 ATP binding site [chemical binding]; other site 251221008054 Walker B motif; other site 251221008055 arginine finger; other site 251221008056 nudix-type nucleoside diphosphatase, YffH/AdpP family; Region: TIGR00052 251221008057 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 251221008058 dimer interface [polypeptide binding]; other site 251221008059 ADP-ribose binding site [chemical binding]; other site 251221008060 active site 251221008061 nudix motif; other site 251221008062 metal binding site [ion binding]; metal-binding site 251221008063 OstA-like protein; Region: OstA; cl00844 251221008064 ABC-type (unclassified) transport system, ATPase component [General function prediction only]; Region: YhbG; COG1137 251221008065 The ABC transporters belonging to the YhbG family are similar to members of the Mj1267_LivG family, which is involved in the transport of branched-chain amino acids. The genes yhbG and yhbN are located in a single operon and may function together in...; Region: ABC_YhbG; cd03218 251221008066 Walker A/P-loop; other site 251221008067 ATP binding site [chemical binding]; other site 251221008068 Q-loop/lid; other site 251221008069 ABC transporter signature motif; other site 251221008070 Walker B; other site 251221008071 D-loop; other site 251221008072 H-loop/switch region; other site 251221008073 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3415 251221008074 Integrase core domain; Region: rve; cl01316 251221008075 Transposase [DNA replication, recombination, and repair]; Region: COG5421 251221008076 Glucose/sorbosone dehydrogenases [Carbohydrate transport and metabolism]; Region: COG2133 251221008077 Protein of unknown function (DUF541); Region: SIMPL; cl01077 251221008078 Serine proteases of the peptidase family S9A [Amino acid transport and metabolism]; Region: COG1505 251221008079 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 251221008080 Uncharacterised protein family (UPF0156); Region: RHH_2; cl01448 251221008081 Phosphatidylserine/phosphatidylglycerophosphate/car diolipin synthases and related enzymes [Lipid metabolism]; Region: Cls; COG1502 251221008082 Catalytic domain of EDTA-resistant nuclease Nuc, vertebrate phospholipase D6, and similar proteins; Region: PLDc_Nuc_like; cd09116 251221008083 putative active site [active] 251221008084 catalytic site [active] 251221008085 Putative catalytic domain, repeat 2, of uncharacterized hypothetical proteins similar to Nuc, an endonuclease from Salmonella typhimurium; Region: PLDc_Nuc_like_unchar1_2; cd09173 251221008086 putative active site [active] 251221008087 catalytic site [active] 251221008088 yrdC domain; Region: Sua5_yciO_yrdC; cl00305 251221008089 single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644 251221008090 shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258 251221008091 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 251221008092 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 251221008093 shikimate binding site; other site 251221008094 NAD(P) binding site [chemical binding]; other site 251221008095 acetolactate synthase, large subunit, biosynthetic type; Region: acolac_lg; TIGR00118 251221008096 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 251221008097 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 251221008098 GDP-binding site [chemical binding]; other site 251221008099 ACT binding site; other site 251221008100 IMP binding site; other site 251221008101 Bacitracin resistance protein BacA; Region: BacA; cl00858 251221008102 Glu-tRNAGln amidotransferase C subunit; Region: Glu-tRNAGln; cl00495 251221008103 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 251221008104 BON domain; Region: BON; cl02771 251221008105 global nitrogen regulator NtcA, cyanobacterial; Region: NtcA_cyano; TIGR03697 251221008106 photosystem I subunit VII; Region: psaC; CHL00065 251221008107 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 251221008108 Iron permease FTR1 family; Region: FTR1; cl00475 251221008109 Helix-hairpin-helix motif; Region: HHH_3; pfam12836 251221008110 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; cl11412 251221008111 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; cl11412 251221008112 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 251221008113 Helix-turn-helix domains; Region: HTH; cl00088 251221008114 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 251221008115 Helix-turn-helix domains; Region: HTH; cl00088 251221008116 putative switch regulator; other site 251221008117 non-specific DNA interactions [nucleotide binding]; other site 251221008118 DNA binding site [nucleotide binding] 251221008119 sequence specific DNA binding site [nucleotide binding]; other site 251221008120 putative cAMP binding site [chemical binding]; other site 251221008121 Domain of unknown function (DUF1821); Region: DUF1821; pfam08851 251221008122 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 251221008123 ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194 251221008124 ATP binding site [chemical binding]; other site 251221008125 dimerization interface [polypeptide binding]; other site 251221008126 LytB protein; Region: LYTB; cl00507 251221008127 (E)-4-hydroxy-3-methyl-but-2-enyl pyrophosphate reductase (IPP and DMAPP forming); Region: ispH_lytB; TIGR00216 251221008128 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD includes...; Region: RuvC_resolvase; cd00529 251221008129 active site 251221008130 putative DNA-binding cleft [nucleotide binding]; other site 251221008131 dimer interface [polypeptide binding]; other site 251221008132 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 251221008133 metal binding site 2 [ion binding]; metal-binding site 251221008134 putative DNA binding helix; other site 251221008135 metal binding site 1 [ion binding]; metal-binding site 251221008136 dimer interface [polypeptide binding]; other site 251221008137 structural Zn2+ binding site [ion binding]; other site 251221008138 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971 251221008139 Cupin domain; Region: Cupin_2; cl09118 251221008140 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 251221008141 putative active site [active] 251221008142 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cl00197 251221008143 active site 251221008144 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 251221008145 ABC-ATPase subunit interface; other site 251221008146 dimer interface [polypeptide binding]; other site 251221008147 putative PBP binding regions; other site 251221008148 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 251221008149 ABC component of the metal-type transporters. This family includes transporters involved in the uptake of various metallic cations such as iron, manganese, and zinc. The ATPases of this group of transporters are very similar to members of...; Region: ABC_Metallic_Cations; cd03235 251221008150 Metal binding protein PsaA. These proteins have been shown to function as initial receptors in ABC transport of Mn2+ and as surface adhesins in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that...; Region: PsaA; cd01137 251221008151 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 251221008152 metal binding site [ion binding]; metal-binding site 251221008153 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 251221008154 ABC component of the metal-type transporters. This family includes transporters involved in the uptake of various metallic cations such as iron, manganese, and zinc. The ATPases of this group of transporters are very similar to members of...; Region: ABC_Metallic_Cations; cd03235 251221008155 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 251221008156 ABC-ATPase subunit interface; other site 251221008157 dimer interface [polypeptide binding]; other site 251221008158 putative PBP binding regions; other site 251221008159 4-alpha-glucanotransferase; Region: Glyco_hydro_77; cl00711 251221008160 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 251221008161 amidase catalytic site [active] 251221008162 Zn binding residues [ion binding]; other site 251221008163 substrate binding site [chemical binding]; other site 251221008164 PIN domain of the Pyrobaculum aerophilum Pae0151 and Pae2754 proteins and homologs; Region: PIN_Pae0151; cd09873 251221008165 putative active site [active] 251221008166 metal binding site [ion binding]; metal-binding site 251221008167 chromosome segregation protein SMC, primarily archaeal type; Region: SMC_prok_A; TIGR02169 251221008168 Barmotin is a tight junction-associated protein expressed in rat epithelial cells which is thought to have an important regulatory role in tight junction barrier function. Barmotin belongs to the SMC protein family. SMC proteins are large; Region: ABC_SMC_barmotin; cd03278 251221008169 Walker A/P-loop; other site 251221008170 ATP binding site [chemical binding]; other site 251221008171 Q-loop/lid; other site 251221008172 SMC proteins Flexible Hinge Domain; Region: SMC_hinge; cl05797 251221008173 Barmotin is a tight junction-associated protein expressed in rat epithelial cells which is thought to have an important regulatory role in tight junction barrier function. Barmotin belongs to the SMC protein family. SMC proteins are large; Region: ABC_SMC_barmotin; cd03278 251221008174 ABC transporter signature motif; other site 251221008175 Walker B; other site 251221008176 D-loop; other site 251221008177 H-loop/switch region; other site 251221008178 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl09155 251221008179 pyruvate kinase; Region: pyruv_kin; TIGR01064 251221008180 domain interfaces; other site 251221008181 active site 251221008182 A subgroup of L-lactate dehydrogenases; Region: LDH_2; cd05292 251221008183 L-lactate dehydrogenase; Reviewed; Region: ldh; PRK00066 251221008184 dimer interface [polypeptide binding]; other site 251221008185 NAD binding site [chemical binding]; other site 251221008186 substrate binding site [chemical binding]; other site 251221008187 tetramer (dimer of dimers) interface [polypeptide binding]; other site 251221008188 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; cl15267 251221008189 glyceraldehyde-3-phosphate dehydrogenase, type I; Region: GAPDH-I; TIGR01534 251221008190 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 251221008191 Predicted membrane protein (DUF2231); Region: DUF2231; cl01730 251221008192 High-affinity nickel-transport protein; Region: NicO; cl00964 251221008193 CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150 251221008194 CobN/Magnesium Chelatase; Region: CobN-Mg_chel; pfam02514 251221008195 CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150 251221008196 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 251221008197 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 251221008198 Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352 251221008199 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl12011 251221008200 DPM1_like represents putative enzymes similar to eukaryotic DPM1; Region: DPM1_like; cd06442 251221008201 Ligand binding site; other site 251221008202 Putative Catalytic site; other site 251221008203 DXD motif; other site 251221008204 Predicted permeases [General function prediction only]; Region: COG0795; cl12074 251221008205 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 251221008206 ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134 251221008207 ABC_KpsT_Wzt The KpsT/Wzt ABC transporter subfamily is involved in extracellular polysaccharide export. Among the variety of membrane-linked or extracellular polysaccharides excreted by bacteria, only capsular polysaccharides, lipopolysaccharides, and...; Region: ABC_KpsT_Wzt; cd03220 251221008208 Walker A/P-loop; other site 251221008209 ATP binding site [chemical binding]; other site 251221008210 Q-loop/lid; other site 251221008211 ABC transporter signature motif; other site 251221008212 Walker B; other site 251221008213 D-loop; other site 251221008214 H-loop/switch region; other site 251221008215 ABC-2 type transporter; Region: ABC2_membrane; cl11417 251221008216 Poly(hydroxyalcanoate) granule associated protein (phasin); Region: Phasin; cl07863 251221008217 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 251221008218 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 251221008219 Glutaredoxin (GRX) family, PKC-interacting cousin of TRX (PICOT)-like subfamily; composed of PICOT and GRX-PICOT-like proteins. The non-PICOT members of this family contain only the GRX-like domain, whereas PICOT contains an N-terminal TRX-like domain...; Region: GRX_PICOT_like; cd03028 251221008220 putative GSH binding site [chemical binding]; other site 251221008221 catalytic residues [active] 251221008222 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 251221008223 NTP_transferases catalyze the transfer of nucleotides onto phosphosugars; Region: NTP_transferase; cd04181 251221008224 active site 251221008225 Substrate binding site; other site 251221008226 Mg++ binding site; other site 251221008227 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 251221008228 putative CoA binding site [chemical binding]; other site 251221008229 phosphoglucosamine mutase; Region: Arch_GlmM; TIGR03990 251221008230 GTP-mannose-1-phosphate guanyltransferase (MPG1 transferase), also known as GDP-mannose pyrophosphorylase, is a bifunctional enzyme with both phosphomannose isomerase (PMI) activity and GDP-mannose phosphorylase (GMP) activity. The protein contains an...; Region: MPG1_transferase; cd05805 251221008231 Bacterial fructose-1,6-bisphosphatase, glpX-encoded. A dimeric enzyme dependent on Mg(2+). glpX-encoded FPBase (FBPase class II) differs from other members of the inositol-phosphatase superfamily by permutation of secondary structure elements. The core...; Region: FBPase_glpX; cd01516 251221008232 putative active site [active] 251221008233 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cl01898 251221008234 The family 20 carbohydrate-binding module (CBM20), also known as the starch-binding domain, is found in a large number of starch degrading enzymes including alpha-amylase, beta-amylase, glucoamylase, and CGTase (cyclodextrin glucanotransferase). CBM20 is...; Region: CBM20; cd05467 251221008235 starch-binding site 2 [chemical binding]; other site 251221008236 starch-binding site 1 [chemical binding]; other site 251221008237 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 251221008238 active site 251221008239 catalytic triad [active] 251221008240 oxyanion hole [active] 251221008241 Putative papain-like cysteine peptidase (DUF1796); Region: DUF1796; pfam08795 251221008242 Transposase [DNA replication, recombination, and repair]; Region: COG5421 251221008243 Transposase [DNA replication, recombination, and repair]; Region: COG5421 251221008244 Transposase [DNA replication, recombination, and repair]; Region: COG5421 251221008245 ParB-like nuclease domain; Region: ParBc; cl02129 251221008246 PRTRC system ParB family protein; Region: PRTRC_parB; TIGR03734 251221008247 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl00284 251221008248 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl12011 251221008249 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 251221008250 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 251221008251 dimer interface [polypeptide binding]; other site 251221008252 putative anticodon binding site; other site 251221008253 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 251221008254 motif 1; other site 251221008255 active site 251221008256 motif 2; other site 251221008257 motif 3; other site 251221008258 DNA-binding transcriptional regulator HcaR; Provisional; Region: PRK09906 251221008259 Helix-turn-helix domains; Region: HTH; cl00088 251221008260 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 251221008261 dimerization interface [polypeptide binding]; other site 251221008262 substrate binding pocket [chemical binding]; other site 251221008263 Dehydrogenases (flavoproteins) [Energy production and conversion]; Region: FixC; COG0644 251221008264 Ferredoxin-like protein [Energy production and conversion]; Region: FixX; COG2440 251221008265 glycerol-3-phosphate dehydrogenase, anaerobic, C subunit; Region: glycerol3P_GlpC; TIGR03379 251221008266 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 251221008267 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715 251221008268 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 251221008269 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 251221008270 Ligand binding site [chemical binding]; other site 251221008271 Electron transfer flavoprotein domain; Region: ETF; pfam01012 251221008272 Protein of unknown function (DUF1469); Region: DUF1469; cl12095 251221008273 CsbD-like; Region: CsbD; cl01888 251221008274 Macro domain, Poa1p_like family. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ADP-ribose...; Region: Macro_Poa1p_like; cd02901 251221008275 ADP-ribose binding site [chemical binding]; other site 251221008276 Predicted glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: ECM4; COG0435 251221008277 C-terminal, alpha helical domain of Class Omega-like Glutathione S-transferases; Region: GST_C_Omega_like; cd03190 251221008278 putative dimer interface [polypeptide binding]; other site 251221008279 N-terminal domain interface [polypeptide binding]; other site 251221008280 putative substrate binding pocket (H-site) [chemical binding]; other site 251221008281 Kelch motif; Region: Kelch_1; cl02701 251221008282 Kelch motif; Region: Kelch_1; cl02701 251221008283 Kelch motif; Region: Kelch_1; cl02701 251221008284 Kelch motif; Region: Kelch_1; cl02701 251221008285 Transaldolase-like proteins from plants and bacteria; Region: Transaldolase_like; cd00955 251221008286 putative active site [active] 251221008287 transaldolase; Provisional; Region: PRK03903 251221008288 catalytic residue [active] 251221008289 MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420 251221008290 trimer interface [polypeptide binding]; other site 251221008291 dimer interface [polypeptide binding]; other site 251221008292 putative active site [active] 251221008293 Domain of unknown function (DUF1815); Region: DUF1815; pfam08844 251221008294 Phage shock protein A (IM30), suppresses sigma54-dependent transcription [Transcription / Signal transduction mechanisms]; Region: PspA; COG1842 251221008295 Protein of unknown function (DUF2949); Region: DUF2949; pfam11165 251221008296 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 251221008297 ribosomal-protein-alanine N-acetyltransferase; Provisional; Region: rimI; PRK09491 251221008298 Coenzyme A binding pocket [chemical binding]; other site 251221008299 ATP phosphoribosyltransferase; Region: HisG; cl15266 251221008300 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl12011 251221008301 Protein of unknown function (DUF520); Region: DUF520; cl00723 251221008302 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 251221008303 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 251221008304 catalytic triad [active] 251221008305 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 251221008306 TPR motif; other site 251221008307 binding surface 251221008308 putative oxidoreductase/HEAT repeat-containing protein; Provisional; Region: PRK13800 251221008309 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 251221008310 putative active site [active] 251221008311 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 251221008312 Tetramer interface [polypeptide binding]; other site 251221008313 active site 251221008314 FMN-binding site [chemical binding]; other site 251221008315 Cupin domain; Region: Cupin_2; cl09118 251221008316 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 251221008317 active site 251221008318 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 251221008319 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 251221008320 Dienelactone hydrolase family; Region: DLH; pfam01738 251221008321 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 251221008322 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 251221008323 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 251221008324 Coenzyme A binding pocket [chemical binding]; other site 251221008325 Uncharacterized metal-binding protein (DUF2227); Region: DUF2227; cl01017 251221008326 Nucleoside 2-deoxyribosyltransferase; Region: Nuc_deoxyrib_tr; cl01450 251221008327 RDD family; Region: RDD; cl00746 251221008328 Gram-negative bacterial tonB protein; Region: TonB; cl10048 251221008329 formamidopyrimidine-DNA glycosylase; Provisional; Region: PRK13945 251221008330 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 251221008331 DNA binding site [nucleotide binding] 251221008332 catalytic residue [active] 251221008333 H2TH interface [polypeptide binding]; other site 251221008334 putative catalytic residues [active] 251221008335 turnover-facilitating residue; other site 251221008336 intercalation triad [nucleotide binding]; other site 251221008337 8OG recognition residue [nucleotide binding]; other site 251221008338 putative reading head residues; other site 251221008339 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 251221008340 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 251221008341 Photosystem I reaction centre subunit IV / PsaE; Region: PSI_PsaE; cl03585 251221008342 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 251221008343 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 251221008344 putative active site [active] 251221008345 putative acetyltransferase; Provisional; Region: PRK03624 251221008346 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 251221008347 Coenzyme A binding pocket [chemical binding]; other site 251221008348 hypothetical protein; Validated; Region: PRK07411 251221008349 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 251221008350 ATP binding site [chemical binding]; other site 251221008351 substrate interface [chemical binding]; other site 251221008352 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 251221008353 active site residue [active] 251221008354 Ubiquitin-like proteins; Region: UBQ; cl00155 251221008355 charged pocket; other site 251221008356 hydrophobic patch; other site 251221008357 Mpr1p, Pad1p N-terminal (MPN) domains; Region: MPN; cl13996 251221008358 recombinase A; Provisional; Region: recA; PRK09354 251221008359 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 251221008360 hexamer interface [polypeptide binding]; other site 251221008361 Walker A motif; other site 251221008362 ATP binding site [chemical binding]; other site 251221008363 Walker B motif; other site 251221008364 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 251221008365 substrate binding site [chemical binding]; other site 251221008366 ligand binding site [chemical binding]; other site 251221008367 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 251221008368 substrate binding site [chemical binding]; other site 251221008369 Predicted membrane protein [Function unknown]; Region: COG4270 251221008370 Domain of unknown function DUF29; Region: DUF29; pfam01724 251221008371 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 251221008372 This family of ATP-binding proteins belongs to a multisubunit transporter involved in drug resistance (BcrA and DrrA), nodulation, lipid transport, and lantibiotic immunity. In bacteria and archaea, these transporters usually include an ATP-binding...; Region: ABC_DR_subfamily_A; cd03230 251221008373 Walker A/P-loop; other site 251221008374 ATP binding site [chemical binding]; other site 251221008375 Q-loop/lid; other site 251221008376 ABC transporter signature motif; other site 251221008377 Walker B; other site 251221008378 D-loop; other site 251221008379 H-loop/switch region; other site 251221008380 L-threonine-O-3-phosphate decarboxylase; Region: L_thr_O3P_dcar; TIGR01140 251221008381 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 251221008382 pyridoxal 5'-phosphate binding site [chemical binding]; other site 251221008383 homodimer interface [polypeptide binding]; other site 251221008384 catalytic residue [active] 251221008385 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 251221008386 IHF - DNA interface [nucleotide binding]; other site 251221008387 IHF dimer interface [polypeptide binding]; other site 251221008388 penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423 251221008389 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 251221008390 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 251221008391 Uncharacterized protein involved in outer membrane biogenesis [Cell envelope biogenesis, outer membrane]; Region: AsmA; COG2982 251221008392 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2911 251221008393 AsmA family; Region: AsmA; pfam05170 251221008394 UbiA prenyltransferase family; Region: UbiA; cl00337 251221008395 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 251221008396 dimerization interface [polypeptide binding]; other site 251221008397 putative DNA binding site [nucleotide binding]; other site 251221008398 putative Zn2+ binding site [ion binding]; other site 251221008399 Prokaryotic metallothionein; Region: Metallothio_Pro; pfam02069 251221008400 Sulfatase; Region: Sulfatase; cl10460 251221008401 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 251221008402 PAS fold; Region: PAS_3; pfam08447 251221008403 putative active site [active] 251221008404 heme pocket [chemical binding]; other site 251221008405 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 251221008406 GAF domain; Region: GAF; cl00853 251221008407 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 251221008408 dimer interface [polypeptide binding]; other site 251221008409 phosphorylation site [posttranslational modification] 251221008410 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 251221008411 ATP binding site [chemical binding]; other site 251221008412 Mg2+ binding site [ion binding]; other site 251221008413 G-X-G motif; other site 251221008414 phosphate regulon transcriptional regulatory protein PhoB; Region: PhoB; TIGR02154 251221008415 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 251221008416 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 251221008417 active site 251221008418 phosphorylation site [posttranslational modification] 251221008419 intermolecular recognition site; other site 251221008420 PAS domain S-box; Region: sensory_box; TIGR00229 251221008421 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 251221008422 putative active site [active] 251221008423 heme pocket [chemical binding]; other site 251221008424 sensor protein ZraS; Provisional; Region: PRK10364 251221008425 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 251221008426 ATP binding site [chemical binding]; other site 251221008427 Mg2+ binding site [ion binding]; other site 251221008428 G-X-G motif; other site 251221008429 Response regulator receiver domain; Region: Response_reg; pfam00072 251221008430 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 251221008431 active site 251221008432 phosphorylation site [posttranslational modification] 251221008433 intermolecular recognition site; other site 251221008434 dimerization interface [polypeptide binding]; other site 251221008435 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 251221008436 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 251221008437 [2Fe-2S] cluster binding site [ion binding]; other site 251221008438 C-terminal catalytic domain of GbcA (glycine betaine catabolism A) from Pseudomonas aeruginosa PAO1 and related aromatic ring hydroxylating dioxygenases; Region: RHO_alpha_C_GbcA-like; cd08884 251221008439 putative alpha subunit interface [polypeptide binding]; other site 251221008440 putative active site [active] 251221008441 putative substrate binding site [chemical binding]; other site 251221008442 Fe binding site [ion binding]; other site 251221008443 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 251221008444 FAD binding domain; Region: FAD_binding_4; pfam01565 251221008445 sn-glycerol-3-phosphate dehydrogenase subunit C; Provisional; Region: glpC; PRK11168 251221008446 Photosystem I psaA/psaB protein; Region: PsaA_PsaB; cl08224 251221008447 Photosystem I psaA/psaB protein; Region: PsaA_PsaB; cl08224 251221008448 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 251221008449 ligand binding site [chemical binding]; other site 251221008450 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 251221008451 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cl15358 251221008452 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4586 251221008453 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 251221008454 Walker A/P-loop; other site 251221008455 ATP binding site [chemical binding]; other site 251221008456 Q-loop/lid; other site 251221008457 ABC transporter signature motif; other site 251221008458 Walker B; other site 251221008459 D-loop; other site 251221008460 H-loop/switch region; other site 251221008461 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4587 251221008462 Protein of unknown function (DUF990); Region: DUF990; cl01496 251221008463 Helix-Turn-Helix DNA binding domain of the BmrR transcription regulator; Region: HTH_BmrR; cd01107 251221008464 DNA binding residues [nucleotide binding] 251221008465 drug binding residues [chemical binding]; other site 251221008466 dimer interface [polypeptide binding]; other site 251221008467 Bacterial transcription activator, effector binding domain; Region: AraC_E_bind; cl01368 251221008468 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 251221008469 GTPase RsgA; Reviewed; Region: PRK01889 251221008470 YjeQ/EngC. YjeQ (YloQ in Bacillus subtilis) represents a protein family whose members are broadly conserved in bacteria and have been shown to be essential to the growth of E. coli and B. subtilis. Proteins of the YjeQ family contain all sequence motifs...; Region: YjeQ_engC; cd01854 251221008471 GTPase/OB domain interface [polypeptide binding]; other site 251221008472 GTPase/Zn-binding domain interface [polypeptide binding]; other site 251221008473 GTP/Mg2+ binding site [chemical binding]; other site 251221008474 G4 box; other site 251221008475 G5 box; other site 251221008476 G1 box; other site 251221008477 Switch I region; other site 251221008478 G2 box; other site 251221008479 G3 box; other site 251221008480 Switch II region; other site 251221008481 Family description; Region: VCBS; pfam13517 251221008482 Family description; Region: VCBS; pfam13517 251221008483 Family description; Region: VCBS; pfam13517 251221008484 Family description; Region: VCBS; pfam13517 251221008485 Family description; Region: VCBS; pfam13517 251221008486 Family description; Region: VCBS; pfam13517 251221008487 Family description; Region: VCBS; pfam13517 251221008488 Protein of unknown function (DUF990); Region: DUF990; cl01496 251221008489 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 251221008490 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 251221008491 active site 251221008492 metal binding site [ion binding]; metal-binding site 251221008493 GST_N family, unknown subfamily 1; composed of uncharacterized proteins, predominantly from bacteria, with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with...; Region: GST_N_1; cd03043 251221008494 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 251221008495 putative C-terminal domain interface [polypeptide binding]; other site 251221008496 putative GSH binding site (G-site) [chemical binding]; other site 251221008497 putative dimer interface [polypeptide binding]; other site 251221008498 C-terminal, alpha helical domain of an unknown subfamily 3 of Glutathione S-transferases; Region: GST_C_3; cd03194 251221008499 putative N-terminal domain interface [polypeptide binding]; other site 251221008500 putative dimer interface [polypeptide binding]; other site 251221008501 putative substrate binding pocket (H-site) [chemical binding]; other site 251221008502 Sodium:solute symporter family; Region: SSF; cl00456 251221008503 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 251221008504 double-strand break repair helicase AddA, alphaproteobacterial type; Region: addA_alphas; TIGR02784 251221008505 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 251221008506 metal ion-dependent adhesion site (MIDAS); other site 251221008507 Helix-turn-helix domains; Region: HTH; cl00088 251221008508 aspartate-alanine antiporter; Region: Asp_Ala_antiprt; TIGR03802 251221008509 Predicted oxidoreductases (related to aryl-alcohol dehydrogenases) [Energy production and conversion]; Region: Tas; COG0667 251221008510 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 251221008511 active site 251221008512 catalytic tetrad [active] 251221008513 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776 251221008514 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 251221008515 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 251221008516 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 251221008517 putative active site [active] 251221008518 Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021 251221008519 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 251221008520 TPP-binding site [chemical binding]; other site 251221008521 Pyrimidine (PYR) binding domain of thiamine pyrophosphate (TPP)-dependent enzymes; Region: TPP_enzyme_PYR; cl11410 251221008522 PYR/PP interface [polypeptide binding]; other site 251221008523 dimer interface [polypeptide binding]; other site 251221008524 TPP binding site [chemical binding]; other site 251221008525 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 251221008526 hypothetical protein; Reviewed; Region: PRK00024 251221008527 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 251221008528 MPN+ (JAMM) motif; other site 251221008529 Zinc-binding site [ion binding]; other site 251221008530 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 251221008531 Protein of unknown function (DUF1579); Region: DUF1579; pfam07617 251221008532 succinyldiaminopimelate transaminase; Validated; Region: PRK07366 251221008533 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 251221008534 pyridoxal 5'-phosphate binding site [chemical binding]; other site 251221008535 homodimer interface [polypeptide binding]; other site 251221008536 catalytic residue [active] 251221008537 This family is the oxydase domain of NRPS (non-ribosomal peptide synthetase) and other proteins that modify polypeptides by cyclizing a thioester to form a ring. These include epoB, part of the epothilone biosynthesis pathway; tubD, part of the tubulysin...; Region: mcbC-like_oxidoreductase; cd02142 251221008538 NADPH bind site [chemical binding]; other site 251221008539 This family is the oxydase domain of NRPS (non-ribosomal peptide synthetase) and other proteins that modify polypeptides by cyclizing a thioester to form a ring. These include epoB, part of the epothilone biosynthesis pathway; tubD, part of the tubulysin...; Region: mcbC-like_oxidoreductase; cd02142 251221008540 putative FMN binding site [chemical binding]; other site 251221008541 NADPH bind site [chemical binding]; other site 251221008542 Peptidase family M23; Region: Peptidase_M23; pfam01551 251221008543 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 251221008544 daunorubicin resistance ABC transporter ATP-binding subunit; Region: drrA; TIGR01188 251221008545 Walker A/P-loop; other site 251221008546 ATP binding site [chemical binding]; other site 251221008547 Q-loop/lid; other site 251221008548 ABC transporter signature motif; other site 251221008549 Walker B; other site 251221008550 D-loop; other site 251221008551 H-loop/switch region; other site 251221008552 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 251221008553 Protein of unknown function (DUF1778); Region: DUF1778; cl01845 251221008554 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 251221008555 Cysteine-rich CPXCG; Region: Cys_rich_CPXG; pfam14255 251221008556 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 251221008557 S-adenosylmethionine binding site [chemical binding]; other site 251221008558 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 251221008559 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581 251221008560 NTP_transferases catalyze the transfer of nucleotides onto phosphosugars; Region: NTP_transferase; cd04181 251221008561 active site 251221008562 Substrate binding site; other site 251221008563 Mg++ binding site; other site 251221008564 chaperone protein DnaJ; Provisional; Region: PRK14284 251221008565 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 251221008566 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 251221008567 X-Prolyl Aminopeptidase 2. E.C. 3.4.11.9. Also known as X-Pro aminopeptidase, proline aminopeptidase, aminopeptidase P, and aminoacylproline aminopeptidase. Catalyses release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP; cd01085 251221008568 active site 251221008569 Chaperone of endosialidase; Region: Peptidase_S74; pfam13884 251221008570 atypical (a) SDRs, subgroup 5; Region: SDR_a5; cd05243 251221008571 NAD(P) binding site [chemical binding]; other site 251221008572 putative active site [active] 251221008573 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 251221008574 Ferritin-like domain; Region: Ferritin; pfam00210 251221008575 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 251221008576 dimerization interface [polypeptide binding]; other site 251221008577 DPS ferroxidase diiron center [ion binding]; other site 251221008578 ion pore; other site 251221008579 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 251221008580 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 251221008581 catalytic residue [active] 251221008582 ribosome maturation protein RimP; Reviewed; Region: PRK00092 251221008583 The eukaryotic Sm and Sm-like (LSm) proteins associate with RNA to form the core domain of the ribonucleoprotein particles involved in a variety of RNA processing events including pre-mRNA splicing, telomere replication, and mRNA degradation. Members of...; Region: Sm_like; cl00259 251221008584 YxlS is a Bacillus subtilis gene of unknown function with two domains that each have an alpha/beta fold. The N-terminal domain is composed of two alpha-helices and a three-stranded beta-sheet, while the C-terminal domain is composed of one alpha-helix...; Region: YlxS_C; cd01734 251221008585 Sm1 motif; other site 251221008586 predicted subunit interaction site [polypeptide binding]; other site 251221008587 RNA binding pocket [nucleotide binding]; other site 251221008588 Sm2 motif; other site 251221008589 transcription elongation factor NusA; Provisional; Region: nusA; PRK12327 251221008590 NusA N-terminal domain; Region: NusA_N; pfam08529 251221008591 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 251221008592 RNA binding site [nucleotide binding]; other site 251221008593 homodimer interface [polypeptide binding]; other site 251221008594 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 251221008595 G-X-X-G motif; other site 251221008596 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 251221008597 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 251221008598 Mur ligase middle domain; Region: Mur_ligase_M; cl15713 251221008599 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 251221008600 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 251221008601 pyruvate kinase; Provisional; Region: PRK06354 251221008602 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl09155 251221008603 domain interfaces; other site 251221008604 active site 251221008605 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; cl01586 251221008606 Domain of unknown function (DUF1817); Region: DUF1817; cl02292 251221008607 Protein of unknown function (DUF1997); Region: DUF1997; pfam09366 251221008608 Uncharacterised BCR, YbaB family COG0718; Region: DUF149; cl00494 251221008609 recombination protein RecR; Reviewed; Region: recR; PRK00076 251221008610 Helix-hairpin-helix DNA-binding motif class 1; Region: HhH1; smart00278 251221008611 RecR protein; Region: RecR; pfam02132 251221008612 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 251221008613 putative active site [active] 251221008614 putative metal-binding site [ion binding]; other site 251221008615 tetramer interface [polypeptide binding]; other site 251221008616 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 251221008617 homotrimer interaction site [polypeptide binding]; other site 251221008618 putative active site [active] 251221008619 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 251221008620 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 251221008621 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 251221008622 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 251221008623 Uncharacterised protein family (UPF0156); Region: RHH_2; cl01448 251221008624 Plasmid stabilisation system protein; Region: Plasmid_stabil; cl11422 251221008625 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 251221008626 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 251221008627 NAD(P) binding site [chemical binding]; other site 251221008628 homotetramer interface [polypeptide binding]; other site 251221008629 homodimer interface [polypeptide binding]; other site 251221008630 active site 251221008631 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 251221008632 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 251221008633 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 251221008634 trimer interface [polypeptide binding]; other site 251221008635 active site 251221008636 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 251221008637 Walker A motif; other site 251221008638 ATP binding site [chemical binding]; other site 251221008639 Walker B motif; other site 251221008640 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 251221008641 HSP70 interaction site [polypeptide binding]; other site 251221008642 Protein of unknown function (DUF3143); Region: DUF3143; pfam11341 251221008643 Sulfotransferase family; Region: Sulfotransfer_2; cl12149 251221008644 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 251221008645 S-adenosylmethionine binding site [chemical binding]; other site 251221008646 Sulfotransferase family; Region: Sulfotransfer_2; cl12149 251221008647 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 251221008648 Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228 251221008649 Metallo-dependent hydrolases, subgroup A is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_A; cd01299 251221008650 active site 251221008651 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 251221008652 active site 251221008653 putative lipid kinase; Reviewed; Region: PRK00861 251221008654 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; cl01255 251221008655 Protein of unknown function DUF86; Region: DUF86; cl01031 251221008656 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 251221008657 active site 251221008658 NTP binding site [chemical binding]; other site 251221008659 metal binding triad [ion binding]; metal-binding site 251221008660 antibiotic binding site [chemical binding]; other site 251221008661 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; cl01255 251221008662 lipoyl synthase; Provisional; Region: PRK12928 251221008663 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 251221008664 FeS/SAM binding site; other site 251221008665 Plasmid stabilisation system protein; Region: Plasmid_stabil; cl11422 251221008666 glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389 251221008667 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 251221008668 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 251221008669 lipoyl attachment site [posttranslational modification]; other site 251221008670 Protein of unknown function (DUF2511); Region: DUF2511; pfam10709 251221008671 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cl00161 251221008672 Protein of unknown function DUF45; Region: DUF45; cl00636 251221008673 radical SAM family uncharacterized protein; Region: rSAM_fuse_unch; TIGR03960 251221008674 radical SAM-linked protein; Region: sam_1_link_chp; TIGR03936 251221008675 Uncharacterized protein conserved in bacteria (DUF2344); Region: DUF2344; cl02090 251221008676 UbiA prenyltransferase family; Region: UbiA; cl00337 251221008677 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 251221008678 intersubunit interface [polypeptide binding]; other site 251221008679 active site 251221008680 catalytic residue [active] 251221008681 YGGT family; Region: YGGT; cl00508 251221008682 Predicted protease with the C-terminal PDZ domain [General function prediction only]; Region: COG3975 251221008683 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 251221008684 PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated; Region: PDZ; cl00117 251221008685 protein binding site [polypeptide binding]; other site 251221008686 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 251221008687 TPR motif; other site 251221008688 binding surface 251221008689 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 251221008690 binding surface 251221008691 TPR motif; other site 251221008692 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 251221008693 binding surface 251221008694 TPR motif; other site 251221008695 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 251221008696 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; cl03056 251221008697 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 251221008698 catalytic site [active] 251221008699 subunit interface [polypeptide binding]; other site 251221008700 Cyanobacterial and plant NDH-1 subunit O; Region: NdhO; pfam11910 251221008701 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 251221008702 IHF dimer interface [polypeptide binding]; other site 251221008703 IHF - DNA interface [nucleotide binding]; other site 251221008704 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 251221008705 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554 251221008706 homotrimer interaction site [polypeptide binding]; other site 251221008707 zinc binding site [ion binding]; other site 251221008708 CDP-binding sites; other site 251221008709 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 251221008710 ribulose-phosphate 3-epimerase; Region: rpe; TIGR01163 251221008711 substrate binding site [chemical binding]; other site 251221008712 hexamer interface [polypeptide binding]; other site 251221008713 metal binding site [ion binding]; metal-binding site 251221008714 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 251221008715 Ligand Binding Site [chemical binding]; other site 251221008716 Isocitrate/isopropylmalate dehydrogenase; Region: Iso_dh; cl00445 251221008717 tartrate dehydrogenase; Provisional; Region: PRK08194 251221008718 Cupin domain; Region: Cupin_2; cl09118 251221008719 Peptidase family M48; Region: Peptidase_M48; cl12018 251221008720 PIN domain of the VapC-like Sll0205 protein and homologs; Region: PIN_Sll0205; cd09872 251221008721 putative active site [active] 251221008722 Phd_YefM; Region: PhdYeFM; cl09153 251221008723 Ferric reductase like transmembrane component; Region: Ferric_reduct; cl01043 251221008724 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 251221008725 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 251221008726 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 251221008727 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 251221008728 CheB methylesterase; Region: CheB_methylest; pfam01339 251221008729 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 251221008730 Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352 251221008731 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl12011 251221008732 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 251221008733 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 251221008734 putative active site [active] 251221008735 heme pocket [chemical binding]; other site 251221008736 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 251221008737 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 251221008738 dimer interface [polypeptide binding]; other site 251221008739 phosphorylation site [posttranslational modification] 251221008740 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 251221008741 ATP binding site [chemical binding]; other site 251221008742 Mg2+ binding site [ion binding]; other site 251221008743 G-X-G motif; other site 251221008744 Response regulator receiver domain; Region: Response_reg; pfam00072 251221008745 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 251221008746 active site 251221008747 phosphorylation site [posttranslational modification] 251221008748 intermolecular recognition site; other site 251221008749 dimerization interface [polypeptide binding]; other site 251221008750 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 251221008751 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 251221008752 non-specific DNA interactions [nucleotide binding]; other site 251221008753 DNA binding site [nucleotide binding] 251221008754 sequence specific DNA binding site [nucleotide binding]; other site 251221008755 putative cAMP binding site [chemical binding]; other site 251221008756 Domain of unknown function (DUF1816); Region: DUF1816; pfam08846 251221008757 mitochondrial precursor proteins import receptor (72 kDa mitochondrial outermembrane protein) (mitochondrial import receptor for the ADP/ATP carrier) (translocase of outermembrane tom70); Region: 3a0801s09; TIGR00990 251221008758 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 251221008759 binding surface 251221008760 TPR motif; other site 251221008761 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 251221008762 binding surface 251221008763 TPR motif; other site 251221008764 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3809 251221008765 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3809 251221008766 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 251221008767 PseudoU_synth_EcTruA: Pseudouridine synthase, Escherichia coli TruA like. This group consists of eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA, Pseudomonas aeruginosa truA and human pseudouridine synthase-like 1 (PUSL1); Region: PseudoU_synth_EcTruA; cd02570 251221008768 dimerization interface 3.5A [polypeptide binding]; other site 251221008769 active site 251221008770 Ribosomal protein L17; Region: Ribosomal_L17; cl00356 251221008771 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 251221008772 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 251221008773 alphaNTD - beta interaction site [polypeptide binding]; other site 251221008774 alphaNTD homodimer interface [polypeptide binding]; other site 251221008775 alphaNTD - beta' interaction site [polypeptide binding]; other site 251221008776 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; cl11613 251221008777 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 251221008778 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 251221008779 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 251221008780 RNA binding surface [nucleotide binding]; other site 251221008781 Ribosomal protein S11; Region: Ribosomal_S11; cl00332 251221008782 Ribosomal protein S13/S18; Region: Ribosomal_S13; cl00331 251221008783 Ribosomal protein L36; Region: Ribosomal_L36; cl00380 251221008784 LOW PSII ACCUMULATION1; Provisional; Region: LPA1; PLN03098 251221008785 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 251221008786 binding surface 251221008787 TPR motif; other site 251221008788 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 251221008789 binding surface 251221008790 TPR motif; other site 251221008791 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 251221008792 binding surface 251221008793 TPR motif; other site 251221008794 Predicted methyltransferase (contains TPR repeat) [General function prediction only]; Region: COG4976 251221008795 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 251221008796 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 251221008797 Clp amino terminal domain; Region: Clp_N; pfam02861 251221008798 Clp amino terminal domain; Region: Clp_N; pfam02861 251221008799 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 251221008800 Walker A motif; other site 251221008801 ATP binding site [chemical binding]; other site 251221008802 Walker B motif; other site 251221008803 arginine finger; other site 251221008804 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 251221008805 Walker A motif; other site 251221008806 ATP binding site [chemical binding]; other site 251221008807 Walker B motif; other site 251221008808 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; cl11083 251221008809 Domain of unknown function DUF29; Region: DUF29; pfam01724 251221008810 Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1), 6-pyrovoyl...; Region: TFold; cl00263 251221008811 active site 251221008812 Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1), 6-pyrovoyl...; Region: TFold; cl00263 251221008813 active site 251221008814 Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511 251221008815 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT; cl15364 251221008816 RNA polymerase sigma factor; Provisional; Region: PRK12518 251221008817 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 251221008818 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 251221008819 DNA binding residues [nucleotide binding] 251221008820 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147 251221008821 Queuosine biosynthesis protein; Region: Queuosine_synth; cl00523 251221008822 1,4-alpha-glucan branching enzyme [Carbohydrate transport and metabolism]; Region: GlgB; COG0296 251221008823 Alpha amylase catalytic domain found in an uncharacterized protein family; Region: AmyAc_4; cd11350 251221008824 active site 251221008825 catalytic site [active] 251221008826 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; cl02706 251221008827 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 251221008828 TPR motif; other site 251221008829 binding surface 251221008830 FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457 251221008831 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 251221008832 binding surface 251221008833 TPR motif; other site 251221008834 Protein of unknown function (DUF1552); Region: HXXSHH; pfam07586 251221008835 CHAT domain; Region: CHAT; cl02083 251221008836 Helix-turn-helix domains; Region: HTH; cl00088 251221008837 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl14614 251221008838 NAD(P) binding site [chemical binding]; other site 251221008839 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 251221008840 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 251221008841 GIY-YIG motif/motif A; other site 251221008842 active site 251221008843 catalytic site [active] 251221008844 putative DNA binding site [nucleotide binding]; other site 251221008845 metal binding site [ion binding]; metal-binding site 251221008846 UvrB/uvrC motif; Region: UVR; pfam02151 251221008847 SERine Proteinase INhibitors (serpins) exhibit conformational polymorphism shifting from native to cleaved, latent, delta, or polymorphic forms. Many serpins, such as antitrypsin and antichymotrypsin, function as serine protease inhibitors which regulate...; Region: SERPIN; cl00137 251221008848 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 251221008849 Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1), 6-pyrovoyl...; Region: TFold; cl00263 251221008850 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 251221008851 putative active site [active] 251221008852 Helix-turn-helix domains; Region: HTH; cl00088 251221008853 Protein of unknown function (DUF3386); Region: DUF3386; pfam11866 251221008854 FAD dependent oxidoreductase; Region: FAD_oxidored; pfam12831 251221008855 Uncharacterized bacterial family of heme peroxidases; Region: An_peroxidase_bacterial_1; cd09819 251221008856 putative heme binding site [chemical binding]; other site 251221008857 putative substrate binding site [chemical binding]; other site 251221008858 TonB-dependent heme/hemoglobin receptor family protein; Region: TonB-hemin; TIGR01785 251221008859 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 251221008860 N-terminal plug; other site 251221008861 ligand-binding site [chemical binding]; other site 251221008862 hemin importer ATP-binding subunit; Provisional; Region: hmuV; PRK13547 251221008863 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 251221008864 Walker A/P-loop; other site 251221008865 ATP binding site [chemical binding]; other site 251221008866 Q-loop/lid; other site 251221008867 ABC transporter signature motif; other site 251221008868 Walker B; other site 251221008869 D-loop; other site 251221008870 H-loop/switch region; other site 251221008871 tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335; cl15440 251221008872 NAD(FAD)-utilizing enzyme possibly involved in translation [Translation, ribosomal structure and biogenesis]; Region: Gid; COG1206 251221008873 riboflavin synthase subunit alpha; Provisional; Region: PRK09289 251221008874 Lumazine binding domain; Region: Lum_binding; pfam00677 251221008875 Lumazine binding domain; Region: Lum_binding; pfam00677 251221008876 Glutathione-dependent formaldehyde-activating enzyme; Region: GFA; cl01553 251221008877 sucrose synthase; Region: sucr_synth; TIGR02470 251221008878 This family is most closely related to the GT1 family of glycosyltransferases. The sucrose-phosphate synthases in this family may be unique to plants and photosynthetic bacteria. This enzyme catalyzes the synthesis of sucrose 6-phosphate from fructose...; Region: GT1_Sucrose_synthase; cd03800 251221008879 putative ADP-binding pocket [chemical binding]; other site 251221008880 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 251221008881 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 251221008882 putative active site [active] 251221008883 putative metal binding site [ion binding]; other site 251221008884 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Ada; COG2169 251221008885 Metal binding domain of Ada; Region: Ada_Zn_binding; pfam02805 251221008886 AlkA N-terminal domain; Region: AlkA_N; cl05528 251221008887 3-methyl-adenine DNA glycosylase II; Provisional; Region: PRK10308 251221008888 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 251221008889 minor groove reading motif; other site 251221008890 helix-hairpin-helix signature motif; other site 251221008891 substrate binding pocket [chemical binding]; other site 251221008892 active site 251221008893 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 251221008894 DNA binding site [nucleotide binding] 251221008895 active site 251221008896 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 251221008897 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 251221008898 RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278 251221008899 RNA/DNA hybrid binding site [nucleotide binding]; other site 251221008900 active site 251221008901 Caulimovirus viroplasmin; Region: Cauli_VI; pfam01693 251221008902 Tic22-like family; Region: Tic22; cl04468 251221008903 Protein of unknown function (DUF1557); Region: DUF1557; pfam07591 251221008904 Carbohydrate-selective porin, OprB family; Region: OprB; pfam04966 251221008905 Gloeo_Verruco repeat; Region: Gloeo_Verruco; TIGR03803 251221008906 Gloeo_Verruco repeat; Region: Gloeo_Verruco; TIGR03803 251221008907 Gloeo_Verruco repeat; Region: Gloeo_Verruco; TIGR03803 251221008908 Gloeo_Verruco repeat; Region: Gloeo_Verruco; TIGR03803 251221008909 Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538 251221008910 Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696 251221008911 LysE type translocator; Region: LysE; cl00565 251221008912 TlpA-like family, DipZ-like subfamily; composed uncharacterized proteins containing a TlpA-like TRX domain. Some members show domain architectures similar to that of E. coli DipZ protein (also known as DsbD). The only eukaryotic members of the TlpA...; Region: TlpA_like_DipZ_like; cd03012 251221008913 catalytic residues [active] 251221008914 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366 251221008915 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694; cl15446 251221008916 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 251221008917 catalytic loop [active] 251221008918 iron binding site [ion binding]; other site 251221008919 YtxH-like protein; Region: YtxH; cl02079 251221008920 Aerobic Cyclase System Fe-containing subunit (ACSF), ferritin-like diiron-binding domain; Region: ACSF; cd01047 251221008921 diiron binding motif [ion binding]; other site 251221008922 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 251221008923 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 251221008924 Coenzyme A binding pocket [chemical binding]; other site 251221008925 Family description; Region: VCBS; pfam13517 251221008926 Family description; Region: VCBS; pfam13517 251221008927 Family description; Region: VCBS; pfam13517 251221008928 Family description; Region: VCBS; pfam13517 251221008929 Family description; Region: VCBS; pfam13517 251221008930 Family description; Region: VCBS; pfam13517 251221008931 Family description; Region: VCBS; pfam13517 251221008932 Family description; Region: VCBS; pfam13517 251221008933 ROK family protein (putative glucokinase); Region: ROK_glcA_fam; TIGR00744 251221008934 OstA-like protein; Region: OstA; cl00844 251221008935 Protein of unknown function (DUF3769); Region: DUF3769; pfam12600 251221008936 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 251221008937 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 251221008938 active site 251221008939 metal binding site [ion binding]; metal-binding site 251221008940 Photosystem II reaction centre I protein (PSII 4.8 kDa protein); Region: PsbI; cl03640 251221008941 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, subunit 9, 39 kDa, (NDUFA9) -like, atypical (a) SDRs; Region: NDUFA9_like_SDR_a; cd05271 251221008942 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 251221008943 putative NAD(P) binding site [chemical binding]; other site 251221008944 active site 251221008945 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 251221008946 Helix-turn-helix domains; Region: HTH; cl00088 251221008947 recombination and DNA strand exchange inhibitor protein; Reviewed; Region: PRK00409 251221008948 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 251221008949 Walker A/P-loop; other site 251221008950 ATP binding site [chemical binding]; other site 251221008951 Q-loop/lid; other site 251221008952 ABC transporter signature motif; other site 251221008953 Walker B; other site 251221008954 D-loop; other site 251221008955 H-loop/switch region; other site 251221008956 Smr domain; Region: Smr; cl02619 251221008957 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cl01898 251221008958 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 251221008959 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 251221008960 CysQ, a 3'-Phosphoadenosine-5'-phosphosulfate (PAPS) 3'-phosphatase, is a bacterial member of the inositol monophosphatase family. It has been proposed that CysQ helps control intracellular levels of PAPS, which is an intermediate in cysteine...; Region: CysQ; cd01638 251221008961 active site 251221008962 Alpha amylase catalytic domain found in cyclomaltodextrinases and related proteins; Region: AmyAc_CMD; cd11338 251221008963 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 251221008964 active site 251221008965 homodimer interface [polypeptide binding]; other site 251221008966 catalytic site [active] 251221008967 PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812 251221008968 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 251221008969 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 251221008970 Probable Catalytic site; other site 251221008971 metal-binding site 251221008972 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743 251221008973 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 251221008974 HIGH motif; other site 251221008975 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 251221008976 active site 251221008977 KMSKS motif; other site 251221008978 Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960 251221008979 tRNA binding surface [nucleotide binding]; other site 251221008980 anticodon binding site; other site 251221008981 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 251221008982 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl12011 251221008983 Hexameric tyrosine-coordinated heme protein (HTHP); Region: HTHP; pfam11534 251221008984 Helix-Turn-Helix DNA binding domain of the transcription regulators NolA and AlbR; Region: HTH_NolA-AlbR; cd04788 251221008985 Cd(II)/Pb(II)-responsive transcriptional regulator; Region: CadR-PbrR; TIGR02047 251221008986 DNA binding residues [nucleotide binding] 251221008987 putative dimer interface [polypeptide binding]; other site 251221008988 TipAS antibiotic-recognition domain; Region: TipAS; pfam07739 251221008989 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 251221008990 putative acyl-acceptor binding pocket; other site 251221008991 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 251221008992 binding surface 251221008993 TPR motif; other site 251221008994 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 251221008995 TPR motif; other site 251221008996 binding surface 251221008997 CHAT domain; Region: CHAT; cl02083 251221008998 Domain of Unknown Function (DUF928); Region: DUF928; pfam06051 251221008999 Caspase, interleukin-1 beta converting enzyme (ICE) homologues; Cysteine-dependent aspartate-directed proteases that mediate programmed cell death (apoptosis). Caspases are synthesized as inactive zymogens and activated by proteolysis of the peptide...; Region: CASc; cl00042 251221009000 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 251221009001 structural tetrad; other site 251221009002 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 251221009003 structural tetrad; other site 251221009004 FOG: WD40 repeat [General function prediction only]; Region: COG2319 251221009005 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 251221009006 structural tetrad; other site 251221009007 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 251221009008 PAS fold; Region: PAS_3; pfam08447 251221009009 putative active site [active] 251221009010 heme pocket [chemical binding]; other site 251221009011 Protein of unknown function (DUF1822); Region: DUF1822; pfam08852 251221009012 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 251221009013 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cl15358 251221009014 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Provisional; Region: PRK14619 251221009015 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 251221009016 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 251221009017 dihydroorotase; Provisional; Region: PRK07575 251221009018 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 251221009019 Dihydroorotase (DHOase), subgroup IIb; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This group contains the archeal members of the DHOase family; Region: DHOase_IIb; cd01318 251221009020 active site 251221009021 lipid A export permease/ATP-binding protein MsbA; Region: MsbA_lipidA; TIGR02203 251221009022 Domain of unknown function DUF39; Region: DUF39; cl14897 251221009023 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 251221009024 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 251221009025 dimer interface [polypeptide binding]; other site 251221009026 phosphorylation site [posttranslational modification] 251221009027 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 251221009028 ATP binding site [chemical binding]; other site 251221009029 Mg2+ binding site [ion binding]; other site 251221009030 G-X-G motif; other site 251221009031 hydrolase, alpha/beta fold family protein; Region: PLN02824 251221009032 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 251221009033 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 251221009034 binding surface 251221009035 TPR motif; other site 251221009036 Outer membrane cobalamin receptor protein [Coenzyme metabolism]; Region: BtuB; COG4206 251221009037 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 251221009038 N-terminal plug; other site 251221009039 ligand-binding site [chemical binding]; other site 251221009040 glutathione synthetase; Provisional; Region: PRK05246 251221009041 Prokaryotic glutathione synthetase, N-terminal domain; Region: GSH-S_N; pfam02951 251221009042 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087 251221009043 Glutaredoxin (GRX) family, GRX bacterial class 1 and 3 (b_1_3)-like subfamily; composed of bacterial GRXs, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, catalyzing the...; Region: GRX_GRXb_1_3_like; cd03418 251221009044 GSH binding site [chemical binding]; other site 251221009045 catalytic residues [active] 251221009046 beta-phosphoglucomutase family hydrolase; Region: PGMB-YQAB-SF; TIGR02009 251221009047 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 251221009048 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 251221009049 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 251221009050 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 251221009051 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 251221009052 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 251221009053 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 251221009054 Lignostilbene-alpha,beta-dioxygenase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3670 251221009055 Retinal pigment epithelial membrane protein; Region: RPE65; cl10080 251221009056 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK02755 251221009057 PseudoU_synth_EcTruB: Pseudouridine synthase, Escherichia coli TruB like. This group consists of bacterial pseudouridine synthases similar to E. coli TruB and Mycobacterium tuberculosis TruB. Pseudouridine synthases catalyze the isomerization of specific...; Region: PseudoU_synth_EcTruB; cd02573 251221009058 RNA binding site [nucleotide binding]; other site 251221009059 active site 251221009060 Manganese-stabilising protein / photosystem II polypeptide; Region: MSP; cl03326 251221009061 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 251221009062 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 251221009063 dimer interface [polypeptide binding]; other site 251221009064 active site 251221009065 CoA binding pocket [chemical binding]; other site 251221009066 Predicted membrane-associated HD superfamily hydrolase [General function prediction only]; Region: COG1480 251221009067 7TM receptor with intracellular HD hydrolase; Region: 7TM-7TMR_HD; pfam07698 251221009068 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 251221009069 Zn2+ binding site [ion binding]; other site 251221009070 Mg2+ binding site [ion binding]; other site 251221009071 Endoribonuclease XendoU; Region: XendoU; pfam09412 251221009072 cobyrinic acid a,c-diamide synthase; Validated; Region: PRK01077 251221009073 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 251221009074 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyrinic Acid a,c-Diamide Synthase; Region: GATase1_CobB; cd03130 251221009075 catalytic triad [active] 251221009076 Peptidase family M41; Region: Peptidase_M41; pfam01434 251221009077 CYTH-like (also known as triphosphate tunnel metalloenzyme (TTM)-like) Phosphatases; Region: CYTH-like_Pase; cl11964 251221009078 CP12 domain; Region: CP12; cl14670 251221009079 PetN; Region: PetN; cl15376 251221009080 PsaD; Region: PsaD; cl03639 251221009081 Cupin domain; Region: Cupin_2; cl09118 251221009082 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 251221009083 NTP_transferases catalyze the transfer of nucleotides onto phosphosugars; Region: NTP_transferase; cd04181 251221009084 active site 251221009085 Substrate binding site; other site 251221009086 Mg++ binding site; other site 251221009087 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 251221009088 Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; pfam04230 251221009089 UDP-N-acetylenolpyruvoylglucosamine reductase; Region: murB; TIGR00179 251221009090 FAD binding domain; Region: FAD_binding_4; pfam01565 251221009091 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 251221009092 colanic acid exporter; Provisional; Region: PRK10459 251221009093 MatE; Region: MatE; cl10513 251221009094 Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; cl01132 251221009095 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 251221009096 UDP-N-acetylglucosamine:LPS N-acetylglucosamine transferase [Cell envelope biogenesis, outer membrane]; Region: MurG; COG0707 251221009097 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 251221009098 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 251221009099 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: GT1_like_7; cd05844 251221009100 putative ADP-binding pocket [chemical binding]; other site 251221009101 PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cl00021 251221009102 sucrose-phosphate synthase, putative, glycosyltransferase domain; Region: sucr_P_syn_N; TIGR02472 251221009103 O-Antigen ligase; Region: Wzy_C; cl04850 251221009104 Uncharacterized protein involved in exopolysaccharide biosynthesis [Cell envelope biogenesis, outer membrane]; Region: GumC; COG3206 251221009105 Chain length determinant protein; Region: Wzz; cl01623 251221009106 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Mrp; COG0489 251221009107 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 251221009108 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 251221009109 Periplasmic protein involved in polysaccharide export, contains SLBB domain of b-grasp fold [Cell wall/membrane/envelope biogenesis]; Region: Wza; COG1596 251221009110 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 251221009111 active site 251221009112 Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004 251221009113 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 251221009114 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 251221009115 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 251221009116 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 251221009117 putative active site [active] 251221009118 PAS fold; Region: PAS_3; pfam08447 251221009119 heme pocket [chemical binding]; other site 251221009120 Bacterial sugar transferase; Region: Bac_transf; cl00939 251221009121 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293 251221009122 Sodium:dicarboxylate symporter family; Region: SDF; cl00573 251221009123 Arginase family; Region: Arginase; cl00306 251221009124 Cobalamin-5-phosphate synthase; Region: CobS; cl00415 251221009125 Domain of unknown function (DUF1821); Region: DUF1821; pfam08851 251221009126 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 251221009127 active site 251221009128 Peptidase family M23; Region: Peptidase_M23; pfam01551 251221009129 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK02705 251221009130 Mur ligase middle domain; Region: Mur_ligase_M; cl15713 251221009131 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 251221009132 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 251221009133 metal binding site 2 [ion binding]; metal-binding site 251221009134 putative DNA binding helix; other site 251221009135 metal binding site 1 [ion binding]; metal-binding site 251221009136 dimer interface [polypeptide binding]; other site 251221009137 structural Zn2+ binding site [ion binding]; other site 251221009138 Rubrerythrin, ferritin-like diiron-binding domain; Region: Rubrerythrin; cd01041 251221009139 binuclear metal center [ion binding]; other site 251221009140 The Delta12 Fatty Acid Desaturase (Delta12-FADS)-like CD includes the integral-membrane enzymes, delta-12 acyl-lipid desaturases, oleate 12-hydroxylases, omega3 and omega6 fatty acid desaturases, and other related proteins, found in a wide range of...; Region: Delta12-FADS-like; cd03507 251221009141 Fatty acid desaturase; Region: FA_desaturase; pfam00487 251221009142 putative di-iron ligands [ion binding]; other site 251221009143 PAS domain S-box; Region: sensory_box; TIGR00229 251221009144 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 251221009145 putative active site [active] 251221009146 heme pocket [chemical binding]; other site 251221009147 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 251221009148 putative active site [active] 251221009149 heme pocket [chemical binding]; other site 251221009150 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 251221009151 PAS fold; Region: PAS_3; pfam08447 251221009152 putative active site [active] 251221009153 heme pocket [chemical binding]; other site 251221009154 GAF domain; Region: GAF; cl00853 251221009155 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 251221009156 dimer interface [polypeptide binding]; other site 251221009157 phosphorylation site [posttranslational modification] 251221009158 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 251221009159 ATP binding site [chemical binding]; other site 251221009160 Mg2+ binding site [ion binding]; other site 251221009161 G-X-G motif; other site 251221009162 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 251221009163 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 251221009164 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 251221009165 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 251221009166 Mg++ binding site [ion binding]; other site 251221009167 putative catalytic motif [active] 251221009168 putative substrate binding site [chemical binding]; other site 251221009169 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 251221009170 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 251221009171 dimer interface [polypeptide binding]; other site 251221009172 putative functional site; other site 251221009173 putative MPT binding site; other site 251221009174 Dienelactone hydrolase family; Region: DLH; pfam01738 251221009175 periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037 251221009176 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 251221009177 protein binding site [polypeptide binding]; other site 251221009178 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 251221009179 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 251221009180 DNA binding residues [nucleotide binding] 251221009181 dimerization interface [polypeptide binding]; other site 251221009182 O-Antigen ligase; Region: Wzy_C; cl04850 251221009183 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 251221009184 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 251221009185 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 251221009186 Uncharacterised protein family (UPF0075); Region: UPF0075; cl04217 251221009187 DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142 251221009188 putative active site [active] 251221009189 catalytic site [active] 251221009190 putative substrate binding site [chemical binding]; other site 251221009191 chaperonin_like superfamily. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. There are 2 main chaperonin groups. The symmetry of type I...; Region: chaperonin_like; cl02777 251221009192 TCP-1/cpn60 chaperonin family; Region: Cpn60_TCP1; pfam00118 251221009193 Protein of unknown function (DUF3288); Region: DUF3288; pfam11691 251221009194 Predicted oxidoreductases of the aldo/keto reductase family [General function prediction only]; Region: COG1453 251221009195 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 251221009196 active site 251221009197 catalytic tetrad [active] 251221009198 Type 1 glutamine amidotransferase (GATase1)-like domain found in Human DJ-1; Region: GATase1_DJ-1; cd03135 251221009199 conserved cys residue [active] 251221009200 Uncharacterised protein family UPF0102; Region: UPF0102; cl00516 251221009201 Protein of unknown function (DUF3120); Region: DUF3120; pfam11318 251221009202 Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819 251221009203 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 251221009204 active site 251221009205 TDP-binding site; other site 251221009206 acceptor substrate-binding pocket; other site 251221009207 homodimer interface [polypeptide binding]; other site 251221009208 putative choline sulfate-utilization transcription factor; Region: chol_sulf_TF; TIGR03418 251221009209 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 251221009210 Predicted esterase [General function prediction only]; Region: COG0400 251221009211 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 251221009212 RNA polymerase sigma factor SigC; Validated; Region: PRK07598 251221009213 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 251221009214 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 251221009215 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 251221009216 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 251221009217 DNA binding residues [nucleotide binding] 251221009218 Protein of unknown function (DUF3529); Region: DUF3529; pfam12046 251221009219 Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040 251221009220 Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; cl00650 251221009221 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 251221009222 oligomer interface [polypeptide binding]; other site 251221009223 active site residues [active] 251221009224 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 251221009225 oligomer interface [polypeptide binding]; other site 251221009226 active site residues [active] 251221009227 stage III sporulation protein AA; Region: spore_III_AA; TIGR02858 251221009228 Fe-S-cluster-containing hydrogenase components 2 [Energy production and conversion]; Region: HycB; COG1142 251221009229 Iron-Sulfur binding protein C terminal; Region: LdpA_C; pfam12617 251221009230 NADH-quinone oxidoreductase cyanobacterial subunit N; Region: NdhN; pfam11909 251221009231 Predicted Fe-S oxidoreductases [General function prediction only]; Region: COG0535 251221009232 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 251221009233 FeS/SAM binding site; other site 251221009234 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 251221009235 UDP-glucuronate decarboxylase (UGD) and related proteins, extended (e) SDRs; Region: UGD_SDR_e; cd05230 251221009236 NAD binding site [chemical binding]; other site 251221009237 putative substrate binding site 2 [chemical binding]; other site 251221009238 putative substrate binding site 1 [chemical binding]; other site 251221009239 active site 251221009240 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 251221009241 active site 251221009242 CMP-NeuAc_Synthase activates N-acetylneuraminic acid by adding CMP moiety; Region: CMP-NeuAc_Synthase; cd02513 251221009243 ligand binding site; other site 251221009244 tetramer interface; other site 251221009245 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 251221009246 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 251221009247 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 251221009248 classical (c) SDRs; Region: SDR_c; cd05233 251221009249 NAD(P) binding site [chemical binding]; other site 251221009250 active site 251221009251 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl12011 251221009252 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 251221009253 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl12011 251221009254 Thiamin pyrophosphokinase, catalytic domain; Region: TPK_catalytic; cl09135 251221009255 polysaccharide export protein Wza; Provisional; Region: PRK15078 251221009256 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 251221009257 SLBB domain; Region: SLBB; pfam10531 251221009258 polysaccharide chain length determinant protein, PEP-CTERM locus subfamily; Region: pepcterm_ChnLen; TIGR03007 251221009259 Chain length determinant protein; Region: Wzz; cl01623 251221009260 Chain length determinant protein; Region: Wzz; cl01623 251221009261 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 251221009262 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 251221009263 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 251221009264 Probable Catalytic site; other site 251221009265 metal-binding site 251221009266 WfgS and WfeV are involved in O-antigen biosynthesis; Region: GT_2_WfgS_like; cd06433 251221009267 metal-binding site 251221009268 Pectate lyase superfamily protein; Region: Pectate_lyase_3; pfam12708 251221009269 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 251221009270 active site 251221009271 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 251221009272 Undecaprenyl-phosphate glucose phosphotransferase; Region: WcaJ_sugtrans; TIGR03023 251221009273 Bacterial sugar transferase; Region: Bac_transf; cl00939 251221009274 GDP-fucose synthetase, extended (e) SDRs; Region: GDP_FS_SDR_e; cd05239 251221009275 GDP-4-keto-6-deoxymannose-3, 5-epimerase-4-reductase; Region: PLN02725 251221009276 NADP binding site [chemical binding]; other site 251221009277 active site 251221009278 putative substrate binding site [chemical binding]; other site 251221009279 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 251221009280 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 251221009281 active site 251221009282 metal binding site [ion binding]; metal-binding site 251221009283 Protein of unknown function (DUF3493); Region: DUF3493; pfam11998 251221009284 Predicted hydrolase of the alpha/beta-hydrolase fold [General function prediction only]; Region: COG0429 251221009285 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 251221009286 PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812 251221009287 Phd_YefM; Region: PhdYeFM; cl09153 251221009288 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 251221009289 Major Facilitator Superfamily; Region: MFS_1; pfam07690 251221009290 putative substrate translocation pore; other site 251221009291 Di-haem cytochrome c peroxidase; Region: CCP_MauG; pfam03150 251221009292 di-heme enzyme, MXAN_0977 family; Region: MXAN_0977_Heme2; TIGR04039 251221009293 Molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: DnaK; COG0443 251221009294 Helix-turn-helix domains; Region: HTH; cl00088 251221009295 Protein of unknown function (DUF2997); Region: DUF2997; pfam11211 251221009296 Protein of unknown function (DUF1257); Region: DUF1257; cl06088 251221009297 Ycf46; Provisional; Region: ycf46; CHL00195 251221009298 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 251221009299 Walker A motif; other site 251221009300 ATP binding site [chemical binding]; other site 251221009301 Walker B motif; other site 251221009302 arginine finger; other site 251221009303 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 251221009304 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 251221009305 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 251221009306 Type 1 glutamine amidotransferase (GATase1)-like domain found in proteins similar to Escherichia coli Hsp31 protein; Region: GATase1_Hsp31_like; cd03141 251221009307 potential catalytic triad [active] 251221009308 conserved cys residue [active] 251221009309 Gluconolactonase [Carbohydrate transport and metabolism]; Region: COG3386 251221009310 YCII-related domain; Region: YCII; cl00999 251221009311 Domain of unknown function (DUF4351); Region: DUF4351; pfam14261 251221009312 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 251221009313 putative active site [active] 251221009314 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 251221009315 putative active site [active] 251221009316 Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980 251221009317 dimer interface [polypeptide binding]; other site 251221009318 [2Fe-2S] cluster binding site [ion binding]; other site 251221009319 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 251221009320 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 251221009321 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; cl08458 251221009322 alanine racemase; Reviewed; Region: alr; PRK00053 251221009323 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 251221009324 active site 251221009325 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 251221009326 dimer interface [polypeptide binding]; other site 251221009327 substrate binding site [chemical binding]; other site 251221009328 catalytic residues [active] 251221009329 dihydroorotase; Validated; Region: pyrC; PRK09357 251221009330 Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317 251221009331 active site 251221009332 Domain of unknown function (DUF2437); Region: DUF2437; pfam10370 251221009333 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 251221009334 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 251221009335 Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389 251221009336 putative active site [active] 251221009337 putative metal binding site [ion binding]; other site 251221009338 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 251221009339 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 251221009340 Helix-turn-helix domains; Region: HTH; cl00088 251221009341 Butanol dehydrogenase catalyzes the conversion of butyraldehyde to butanol with the cofactor NAD(P)H being oxidized in the process; Region: BDH; cd08187 251221009342 Iron-containing alcohol dehydrogenase; Region: Fe-ADH; pfam00465 251221009343 dimer interface [polypeptide binding]; other site 251221009344 active site 251221009345 metal binding site [ion binding]; metal-binding site 251221009346 Old yellow enzyme (OYE) YqjM-like FMN binding domain. YqjM is involved in the oxidative stress response of Bacillus subtilis. Like the other OYE members, each monomer of YqjM contains FMN as a non-covalently bound cofactor and uses NADPH as a reducing...; Region: OYE_YqiM_FMN; cd02932 251221009347 active site 251221009348 FMN binding site [chemical binding]; other site 251221009349 substrate binding site [chemical binding]; other site 251221009350 homotetramer interface [polypeptide binding]; other site 251221009351 catalytic residue [active] 251221009352 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 251221009353 Antibiotic biosynthesis monooxygenase; Region: ABM; cl10022 251221009354 Antibiotic biosynthesis monooxygenase; Region: ABM; cl10022 251221009355 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 251221009356 Domain of unknown function (DUF4281); Region: DUF4281; pfam14108 251221009357 Uncharacterised ACR, YggU family COG1872; Region: DUF167; cl00811 251221009358 Transposase domain (DUF772); Region: DUF772; cl12084 251221009359 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 251221009360 CarD-like/TRCF domain; Region: CarD_TRCF; cl00588 251221009361 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 251221009362 ATP binding site [chemical binding]; other site 251221009363 putative Mg++ binding site [ion binding]; other site 251221009364 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 251221009365 nucleotide binding region [chemical binding]; other site 251221009366 ATP-binding site [chemical binding]; other site 251221009367 TRCF domain; Region: TRCF; cl04088 251221009368 Ribosomal L28 family; Region: Ribosomal_L28; cl00367 251221009369 Sucrose-6F-phosphate phosphohydrolase; Region: S6PP; pfam05116 251221009370 This family is most closely related to the GT1 family of glycosyltransferases. The sucrose-phosphate synthases in this family may be unique to plants and photosynthetic bacteria. This enzyme catalyzes the synthesis of sucrose 6-phosphate from fructose...; Region: GT1_Sucrose_synthase; cd03800 251221009371 UDP-N-acetylglucosamine: 1L-myo-inositol-1-phosphate 1-alpha-D-N-acetylglucosaminyltransferase; Region: mycothiol_MshA; TIGR03449 251221009372 putative ADP-binding pocket [chemical binding]; other site 251221009373 Protein of unknown function (DUF2808); Region: DUF2808; pfam10989 251221009374 S-layer homology domain; Region: SLH; pfam00395 251221009375 S-layer homology domain; Region: SLH; pfam00395 251221009376 Domain of unknown function (DUF4351); Region: DUF4351; pfam14261 251221009377 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 251221009378 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 251221009379 binding surface 251221009380 TPR motif; other site 251221009381 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 251221009382 putative active site [active] 251221009383 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 251221009384 Uncharacterized Candidatus kuenenia aldehyde dehydrogenase AldH (CAJ73105)-like; Region: ALDH_AldH-CAJ73105; cd07131 251221009385 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 251221009386 NAD binding site [chemical binding]; other site 251221009387 catalytic residues [active] 251221009388 4-aminobutyrate aminotransferase; Provisional; Region: PRK05769 251221009389 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 251221009390 inhibitor-cofactor binding pocket; inhibition site 251221009391 pyridoxal 5'-phosphate binding site [chemical binding]; other site 251221009392 catalytic residue [active] 251221009393 Domain of unknown function (DUF1338); Region: DUF1338; cl02226 251221009394 Predicted ATPase [General function prediction only]; Region: COG4637 251221009395 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 251221009396 Walker A/P-loop; other site 251221009397 ATP binding site [chemical binding]; other site 251221009398 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 251221009399 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 251221009400 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 251221009401 ligand binding site [chemical binding]; other site 251221009402 flexible hinge region; other site 251221009403 MatE; Region: MatE; cl10513 251221009404 Integrase core domain; Region: rve; cl01316 251221009405 Helix-turn-helix domains; Region: HTH; cl00088 251221009406 putative transposase OrfB; Reviewed; Region: PHA02517 251221009407 Integrase core domain; Region: rve; cl01316 251221009408 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 251221009409 Transcriptional regulators [Transcription]; Region: MarR; COG1846 251221009410 Helix-turn-helix domains; Region: HTH; cl00088 251221009411 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 251221009412 binding surface 251221009413 TPR motif; other site 251221009414 GTPase YlqF; Reviewed; Region: rbgA; PRK09563 251221009415 YlqF. Proteins of the YlqF family contain all sequence motifs typical of the vast class of P-loop-containing GTPases, but show a circular permutation, with a G4-G1-G3 pattern of motifs as opposed to the regular G1-G3-G4 pattern seen in most GTPases. The...; Region: YlqF; cd01856 251221009416 GTP/Mg2+ binding site [chemical binding]; other site 251221009417 G4 box; other site 251221009418 G5 box; other site 251221009419 G1 box; other site 251221009420 Switch I region; other site 251221009421 G2 box; other site 251221009422 G3 box; other site 251221009423 Switch II region; other site 251221009424 Bacterial protein of unknown function (DUF924); Region: DUF924; cl01561 251221009425 cytochrome c biogenesis protein CcmA; Provisional; Region: PRK13539 251221009426 serine racemase; Region: PLN02970 251221009427 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 251221009428 tetramer interface [polypeptide binding]; other site 251221009429 pyridoxal 5'-phosphate binding site [chemical binding]; other site 251221009430 catalytic residue [active] 251221009431 Mechanosensitive ion channel; Region: MS_channel; pfam00924 251221009432 Dipeptidyl peptidase IV (DPP IV) N-terminal region; Region: DPPIV_N; pfam00930 251221009433 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 251221009434 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 251221009435 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl12011 251221009436 SpoVT / AbrB like domain; Region: SpoVT_AbrB; cl00877 251221009437 PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881 251221009438 oligomeric interface; other site 251221009439 putative active site [active] 251221009440 homodimer interface [polypeptide binding]; other site 251221009441 Coproporphyrinogen III oxidase; Region: Coprogen_oxidas; cl00433 251221009442 Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717 251221009443 substrate binding site [chemical binding]; other site 251221009444 active site 251221009445 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 251221009446 alpha-glucan phosphorylases; Region: more_P_ylases; TIGR02094 251221009447 RNA polymerase sigma factor; Provisional; Region: PRK12514 251221009448 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 251221009449 Walker A motif; other site 251221009450 ATP binding site [chemical binding]; other site 251221009451 Walker B motif; other site 251221009452 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 251221009453 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 251221009454 catalytic residues [active] 251221009455 catalytic nucleophile [active] 251221009456 Presynaptic Site I dimer interface [polypeptide binding]; other site 251221009457 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 251221009458 Synaptic Flat tetramer interface [polypeptide binding]; other site 251221009459 Synaptic Site I dimer interface [polypeptide binding]; other site 251221009460 DNA binding site [nucleotide binding] 251221009461 Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718 251221009462 Virulence-associated protein E; Region: VirE; pfam05272 251221009463 Transposase; Region: HTH_Tnp_IS630; pfam01710 251221009464 Uncharacterized phage-associated protein [Function unknown]; Region: GepA; COG3600 251221009465 Phage protein D [General function prediction only]; Region: COG3500; cl12180 251221009466 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_9; cd07245 251221009467 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 251221009468 dimer interface [polypeptide binding]; other site 251221009469 putative metal binding site [ion binding]; other site 251221009470 Ribosomal protein L18e/L15; Region: Ribosomal_L18e; cl12022 251221009471 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 251221009472 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 251221009473 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 251221009474 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 251221009475 23S rRNA interface [nucleotide binding]; other site 251221009476 L21e interface [polypeptide binding]; other site 251221009477 5S rRNA interface [nucleotide binding]; other site 251221009478 L27 interface [polypeptide binding]; other site 251221009479 L5 interface [polypeptide binding]; other site 251221009480 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 251221009481 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 251221009482 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 251221009483 Ribosomal protein S8; Region: Ribosomal_S8; cl00330 251221009484 Ribosomal protein S14p/S29e; Region: Ribosomal_S14; cl00355 251221009485 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 251221009486 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 251221009487 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 251221009488 ribosomal protein L24, bacterial/organelle; Region: rplX_bact; TIGR01079 251221009489 Ribosomal protein L14p/L23e; Region: Ribosomal_L14; cl00328 251221009490 Ribosomal protein S17; Region: Ribosomal_S17; cl00351 251221009491 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 251221009492 putative translocon interaction site; other site 251221009493 23S rRNA interface [nucleotide binding]; other site 251221009494 signal recognition particle (SRP54) interaction site; other site 251221009495 L23 interface [polypeptide binding]; other site 251221009496 trigger factor interaction site; other site 251221009497 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 251221009498 23S rRNA interface [nucleotide binding]; other site 251221009499 5S rRNA interface [nucleotide binding]; other site 251221009500 putative antibiotic binding site [chemical binding]; other site 251221009501 L25 interface [polypeptide binding]; other site 251221009502 L27 interface [polypeptide binding]; other site 251221009503 ribosomal protein S3; Region: rps3; CHL00048 251221009504 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 251221009505 G-X-X-G motif; other site 251221009506 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 251221009507 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 251221009508 putative translocon binding site; other site 251221009509 protein-rRNA interface [nucleotide binding]; other site 251221009510 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 251221009511 gamma-glutamyl phosphate reductase; Region: proA; TIGR00407 251221009512 putative catalytic cysteine [active] 251221009513 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 251221009514 S17 interaction site [polypeptide binding]; other site 251221009515 S8 interaction site; other site 251221009516 16S rRNA interaction site [nucleotide binding]; other site 251221009517 streptomycin interaction site [chemical binding]; other site 251221009518 23S rRNA interaction site [nucleotide binding]; other site 251221009519 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 251221009520 Ribosomal protein S7p/S5e; Region: Ribosomal_S7; cl00313 251221009521 elongation factor G; Reviewed; Region: PRK00007 251221009522 Elongation factor G (EF-G) subfamily. Translocation is mediated by EF-G (also called translocase). The structure of EF-G closely resembles that of the complex between EF-Tu and tRNA. This is an example of molecular mimicry; a protein domain evolved so...; Region: EF-G; cd01886 251221009523 G1 box; other site 251221009524 putative GEF interaction site [polypeptide binding]; other site 251221009525 GTP/Mg2+ binding site [chemical binding]; other site 251221009526 Switch I region; other site 251221009527 G2 box; other site 251221009528 G3 box; other site 251221009529 Switch II region; other site 251221009530 G4 box; other site 251221009531 G5 box; other site 251221009532 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 251221009533 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 251221009534 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 251221009535 elongation factor Tu; Region: tufA; CHL00071 251221009536 EF-Tu subfamily. This subfamily includes orthologs of translation elongation factor EF-Tu in bacteria, mitochondria, and chloroplasts. It is one of several GTP-binding translation factors found in the larger family of GTP-binding elongation factors; Region: EF_Tu; cd01884 251221009537 G1 box; other site 251221009538 GEF interaction site [polypeptide binding]; other site 251221009539 GTP/Mg2+ binding site [chemical binding]; other site 251221009540 Switch I region; other site 251221009541 G2 box; other site 251221009542 G3 box; other site 251221009543 Switch II region; other site 251221009544 G4 box; other site 251221009545 G5 box; other site 251221009546 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 251221009547 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 251221009548 Antibiotic Binding Site [chemical binding]; other site 251221009549 Ribosomal protein S10p/S20e; Region: Ribosomal_S10; cl00314 251221009550 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 251221009551 putative active site [active] 251221009552 AAK_NAGK-C: N-Acetyl-L-glutamate kinase - cyclic (NAGK-C) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine biosynthesis found in some bacteria and photosynthetic organisms using the...; Region: AAK_NAGK-C; cd04250 251221009553 feedback inhibition sensing region; other site 251221009554 homohexameric interface [polypeptide binding]; other site 251221009555 nucleotide binding site [chemical binding]; other site 251221009556 N-acetyl-L-glutamate binding site [chemical binding]; other site 251221009557 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 251221009558 DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK07374 251221009559 DNA polymerase alpha chain like domain; Region: POLIIIAc; smart00481 251221009560 Bacterial DNA polymerase III alpha subunit; Region: DNA_pol3_alpha; pfam07733 251221009561 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 251221009562 generic binding surface I; other site 251221009563 generic binding surface II; other site 251221009564 Orange carotenoid protein, N-terminal; Region: Carot_N; pfam09150 251221009565 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 251221009566 Fe-S oxidoreductase [Energy production and conversion]; Region: COG1032 251221009567 B12 binding domain_like associated with radical SAM domain. This domain shows similarity with B12 (adenosylcobamide) binding domains found in several enzymes, such as glutamate mutase, methionine synthase and methylmalonyl-CoA mutase, but it lacks the...; Region: radical_SAM_B12_BD; cd02068 251221009568 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: APH_ChoK_like; cl15691 251221009569 Phosphotransferase enzyme family; Region: APH; pfam01636 251221009570 active site 251221009571 substrate binding site [chemical binding]; other site 251221009572 ATP binding site [chemical binding]; other site 251221009573 yrdC domain; Region: Sua5_yciO_yrdC; cl00305 251221009574 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 251221009575 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 251221009576 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 251221009577 classical (c) SDRs; Region: SDR_c; cd05233 251221009578 NAD(P) binding site [chemical binding]; other site 251221009579 active site 251221009580 Integrase core domain; Region: rve; cl01316 251221009581 Rifampin ADP-ribosyl transferase; Region: Arr-ms; pfam12120 251221009582 YCII-related domain; Region: YCII; cl00999 251221009583 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 251221009584 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 251221009585 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 251221009586 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 251221009587 catalytic residue [active] 251221009588 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3415 251221009589 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 251221009590 dimerization interface [polypeptide binding]; other site 251221009591 putative DNA binding site [nucleotide binding]; other site 251221009592 putative Zn2+ binding site [ion binding]; other site 251221009593 S-layer homology domain; Region: SLH; pfam00395 251221009594 Carbohydrate-selective porin, OprB family; Region: OprB; pfam04966 251221009595 Carbohydrate-selective porin [Cell envelope biogenesis, outer membrane]; Region: OprB; COG3659 251221009596 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 251221009597 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 251221009598 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 251221009599 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl15260 251221009600 Na+/melibiose symporter and related transporters [Carbohydrate transport and metabolism]; Region: MelB; COG2211 251221009601 GUN4-like; Region: GUN4; pfam05419 251221009602 Uncharacterized protein predicted to be involved in C-type cytochrome biogenesis [Posttranslational modification, protein turnover, chaperones / Energy production and conversion]; Region: COG4233 251221009603 Thiol:disulfide interchange protein [Posttranslational modification, protein turnover, chaperones / Energy production and conversion]; Region: COG4232 251221009604 DsbD gamma family; DsbD gamma is the C-terminal periplasmic domain of the bacterial protein DsbD. It contains a CXXC motif in a TRX fold and shuttles the reducing potential from the membrane domain (DsbD beta) to the N-terminal periplasmic domain (DsbD...; Region: DsbDgamma; cd02953 251221009605 DsbD alpha interface [polypeptide binding]; other site 251221009606 catalytic residues [active] 251221009607 Peroxiredoxin (PRX)-like 1 family; hypothetical proteins that show sequence similarity to PRXs. Members of this group contain a conserved cysteine that aligns to the first cysteine in the CXXC motif of TRX. This does not correspond to the peroxidatic...; Region: PRX_like1; cd02969 251221009608 putative catalytic residue [active] 251221009609 Ribonucleotide reductase, all-alpha domain; Region: Ribonuc_red_lgN; pfam00317 251221009610 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 251221009611 Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein; Region: Hint; cd00081 251221009612 thioester formation/cholesterol transfer; other site 251221009613 protein-splicing catalytic site; other site 251221009614 Intein/homing endonuclease [DNA replication, recombination, and repair]; Region: COG1372 251221009615 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cl14780 251221009616 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 251221009617 Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein; Region: Hint; cd00081 251221009618 thioester formation/cholesterol transfer; other site 251221009619 protein-splicing catalytic site; other site 251221009620 DNA endonuclease related to intein-encoded endonucleases [DNA replication, recombination, and repair]; Region: COG3780 251221009621 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 251221009622 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 251221009623 Proto-chlorophyllide reductase 57 kD subunit; Region: PCP_red; pfam08369 251221009624 Uncharacterized protein, similar to the N-terminal domain of Lon protease [General function prediction only]; Region: COG2802 251221009625 alanine dehydrogenase; Region: alaDH; TIGR00518 251221009626 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 251221009627 S-adenosylmethionine binding site [chemical binding]; other site 251221009628 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 251221009629 This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809 251221009630 Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182 251221009631 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cl01898 251221009632 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 251221009633 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 251221009634 N-terminal plug; other site 251221009635 ligand-binding site [chemical binding]; other site 251221009636 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 251221009637 putative active site [active] 251221009638 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 251221009639 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 251221009640 N-terminal plug; other site 251221009641 ligand-binding site [chemical binding]; other site 251221009642 YCII-related domain; Region: YCII; cl00999 251221009643 Peptidase M14 Succinylglutamate desuccinylase (ASTE)/aspartoacylase (ASPA)-like; uncharacterized subgroup; Region: M14_ASTE_ASPA_like_3; cd06253 251221009644 Succinylglutamate desuccinylase / Aspartoacylase family; Region: AstE_AspA; pfam04952 251221009645 putative active site [active] 251221009646 Zn binding site [ion binding]; other site 251221009647 Peptidase M14 Succinylglutamate desuccinylase (ASTE)/aspartoacylase (ASPA)-like; uncharacterized subgroup; Region: M14_ASTE_ASPA_like_3; cd06253 251221009648 Succinylglutamate desuccinylase / Aspartoacylase family; Region: AstE_AspA; pfam04952 251221009649 putative active site [active] 251221009650 Zn binding site [ion binding]; other site 251221009651 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 251221009652 ATP binding site [chemical binding]; other site 251221009653 putative Mg++ binding site [ion binding]; other site 251221009654 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 251221009655 nucleotide binding region [chemical binding]; other site 251221009656 ATP-binding site [chemical binding]; other site 251221009657 Uncharacterized conserved protein [Function unknown]; Region: COG1656; cl09136 251221009658 Protein of unknown function (DUF433); Region: DUF433; cl01030 251221009659 phosphoglucomutase; Region: PLN02307 251221009660 Phosphoglucomutase 1 (PGM1) catalyzes the bidirectional interconversion of glucose-1-phosphate (G-1-P) and glucose-6-phosphate (G-6-P) via a glucose 1,6-diphosphate intermediate, an important metabolic step in prokaryotes and eukaryotes. In one direction; Region: PGM1; cd03085 251221009661 substrate binding site [chemical binding]; other site 251221009662 dimer interface [polypeptide binding]; other site 251221009663 active site 251221009664 metal binding site [ion binding]; metal-binding site 251221009665 Protein of unknown function (DUF2808); Region: DUF2808; pfam10989 251221009666 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 251221009667 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 251221009668 putative active site [active] 251221009669 heme pocket [chemical binding]; other site 251221009670 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 251221009671 GAF domain; Region: GAF; cl00853 251221009672 Histidine kinase; Region: HisKA_3; pfam07730 251221009673 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 251221009674 ATP binding site [chemical binding]; other site 251221009675 Mg2+ binding site [ion binding]; other site 251221009676 G-X-G motif; other site 251221009677 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 251221009678 The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915 251221009679 Predicted permeases [General function prediction only]; Region: COG0730; cl00498 251221009680 Protein of unknown function (DUF1634); Region: DUF1634; cl01741 251221009681 aminoethylphosphonate catabolism associated LysR family transcriptional regulator; Region: phn_lysR; TIGR03339 251221009682 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 251221009683 Acylphosphatase; Region: Acylphosphatase; cl00551 251221009684 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 251221009685 Glycogen debranching enzyme N terminal; Region: GDE_N; pfam12439 251221009686 glycogen debranching enzyme, archaeal type, putative; Region: gde_arch; TIGR01561 251221009687 Bacterial alpha-L-rhamnosidase; Region: Bac_rhamnosid; cl01801 251221009688 Isocitrate/isopropylmalate dehydrogenase; Region: Iso_dh; cl00445 251221009689 Uncharacterised protein family (UPF0156); Region: RHH_2; cl01448 251221009690 Plasmid stabilisation system protein; Region: Plasmid_stabil; cl11422 251221009691 Glucose/sorbosone dehydrogenases [Carbohydrate transport and metabolism]; Region: COG2133 251221009692 Mismatch repair ATPase (MutS family) [DNA replication, recombination, and repair]; Region: MutS; COG0249 251221009693 MutS-like homolog in eukaryotes. The MutS protein initiates DNA mismatch repair by recognizing mispaired and unpaired bases embedded in duplex DNA and activating endo- and exonucleases to remove the mismatch. Members of the MutS family possess...; Region: ABC_MutS-like; cd03283 251221009694 Walker A/P-loop; other site 251221009695 ATP binding site [chemical binding]; other site 251221009696 Q-loop/lid; other site 251221009697 ABC transporter signature motif; other site 251221009698 Walker B; other site 251221009699 D-loop; other site 251221009700 H-loop/switch region; other site 251221009701 Bacterial SH3 domain; Region: SH3_3; cl02551 251221009702 NlpC/P60 family; Region: NLPC_P60; cl11438 251221009703 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl09108 251221009704 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 251221009705 homotrimer interaction site [polypeptide binding]; other site 251221009706 putative active site [active] 251221009707 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; cl00500 251221009708 N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436 251221009709 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 251221009710 Semialdehyde dehydrogenase, dimerisation domain; Region: Semialdhyde_dhC; pfam02774 251221009711 Rubrerythrin, ferritin-like diiron-binding domain; Region: Rubrerythrin; cd01041 251221009712 binuclear metal center [ion binding]; other site 251221009713 N-acetylmuramic acid-6-phosphate etherase; Reviewed; Region: murQ; PRK05441 251221009714 N-acetylmuramic acid 6-phosphate etherase. Members of this family contain the SIS (Sugar ISomerase) domain. The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. The bacterial cell wall sugar N-acetylmuramic acid...; Region: SIS_Etherase; cd05007 251221009715 putative active site [active] 251221009716 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 251221009717 putative active site [active] 251221009718 3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK07314 251221009719 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 251221009720 dimer interface [polypeptide binding]; other site 251221009721 active site 251221009722 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14333 251221009723 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 251221009724 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 251221009725 FeS/SAM binding site; other site 251221009726 TRAM domain; Region: TRAM; cl01282 251221009727 nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071 251221009728 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 251221009729 active site 251221009730 (T/H)XGH motif; other site 251221009731 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 251221009732 active site 251221009733 ATP binding site [chemical binding]; other site 251221009734 substrate binding site [chemical binding]; other site 251221009735 activation loop (A-loop); other site 251221009736 SelR domain; Region: SelR; cl00369 251221009737 Protein of unknown function (DUF2807); Region: DUF2807; pfam10988 251221009738 Protein of unknown function (DUF3593); Region: DUF3593; pfam12159 251221009739 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 251221009740 16S/18S rRNA binding site [nucleotide binding]; other site 251221009741 S13e-L30e interaction site [polypeptide binding]; other site 251221009742 25S rRNA binding site [nucleotide binding]; other site 251221009743 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 251221009744 multidrug efflux system subunit MdtC; Provisional; Region: PRK10614 251221009745 Protein export membrane protein; Region: SecD_SecF; cl14618 251221009746 TIR domain; Region: TIR; cl02060 251221009747 Protein of unknown function (DUF1393); Region: DUF1393; cl01942 251221009748 Ribosome-binding factor A; Region: RBFA; cl00542 251221009749 Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152 251221009750 heterotetramer interface [polypeptide binding]; other site 251221009751 active site pocket [active] 251221009752 cleavage site 251221009753 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 251221009754 DNA binding residues [nucleotide binding] 251221009755 dimerization interface [polypeptide binding]; other site 251221009756 Protein of unknown function, DUF482; Region: DUF482; pfam04339 251221009757 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 251221009758 NurA domain; Region: NurA; cl09134 251221009759 RF-1 domain; Region: RF-1; cl02875 251221009760 THUMP domain; Region: THUMP; cl12076 251221009761 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl12011 251221009762 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 251221009763 catalytic residues [active] 251221009764 dimer interface [polypeptide binding]; other site 251221009765 Thermus thermophilus CsoR, a Cu(I)-sensing transcriptional regulator, and related domains; this domain family was previously known as part of DUF156; Region: TthCsoR-like_DUF156; cd10151 251221009766 putative homotetramer interface [polypeptide binding]; other site 251221009767 putative homodimer interface [polypeptide binding]; other site 251221009768 allosteric switch controlling residues; other site 251221009769 putative metal binding site [ion binding]; other site 251221009770 putative homodimer-homodimer interface [polypeptide binding]; other site 251221009771 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 251221009772 metal-binding site [ion binding] 251221009773 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 251221009774 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 251221009775 metal-binding site [ion binding] 251221009776 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 251221009777 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 251221009778 motif II; other site 251221009779 nickel responsive regulator; Provisional; Region: PRK00630 251221009780 PemK-like protein; Region: PemK; cl00995 251221009781 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 251221009782 Fasciclin domain; Region: Fasciclin; cl02663 251221009783 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cl11426 251221009784 hopene-associated glycosyltransferase HpnB; Region: HpnB; TIGR03469 251221009785 CESA_like is the cellulose synthase superfamily; Region: CESA_like; cd06423 251221009786 DXD motif; other site 251221009787 squalene-hopene cyclase; Region: hopene_cyclase; TIGR01507 251221009788 Squalene cyclase (SQCY) domain subgroup 1; found in class II terpene cyclases that have an alpha 6 - alpha 6 barrel fold. Squalene cyclase (SQCY) and 2,3-oxidosqualene cyclase (OSQCY) are integral membrane proteins that catalyze a cationic cyclization...; Region: SQCY_1; cd02892 251221009789 Active site cavity [active] 251221009790 catalytic acid [active] 251221009791 Trans-Isoprenyl Diphosphate Synthases, head-to-head; Region: Trans_IPPS_HH; cd00683 251221009792 active site lid residues [active] 251221009793 substrate binding pocket [chemical binding]; other site 251221009794 catalytic residues [active] 251221009795 substrate-Mg2+ binding site; other site 251221009796 aspartate-rich region 1; other site 251221009797 aspartate-rich region 2; other site 251221009798 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 251221009799 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 251221009800 putative active site [active] 251221009801 Gloeo_Verruco repeat; Region: Gloeo_Verruco; TIGR03803 251221009802 Gloeo_Verruco repeat; Region: Gloeo_Verruco; TIGR03803 251221009803 Gloeo_Verruco repeat; Region: Gloeo_Verruco; TIGR03803 251221009804 Gloeo_Verruco repeat; Region: Gloeo_Verruco; TIGR03803 251221009805 Gloeo_Verruco repeat; Region: Gloeo_Verruco; TIGR03803 251221009806 DNA replication protein [DNA replication, recombination, and repair]; Region: DnaC; COG1484 251221009807 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 251221009808 Walker A motif; other site 251221009809 ATP binding site [chemical binding]; other site 251221009810 Walker B motif; other site 251221009811 Integrase core domain; Region: rve; cl01316 251221009812 arginine decarboxylase; Provisional; Region: PRK05354 251221009813 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Arginine Decarboxylase; Region: PLPDE_III_ADC; cd06830 251221009814 dimer interface [polypeptide binding]; other site 251221009815 active site 251221009816 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 251221009817 catalytic residues [active] 251221009818 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 251221009819 RNA polymerase sigma factor, TIGR02999 family; Region: Sig-70_X6 251221009820 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cl15358 251221009821 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 251221009822 Catalytic domain of Protein Kinases; Region: PKc; cd00180 251221009823 active site 251221009824 ATP binding site [chemical binding]; other site 251221009825 substrate binding site [chemical binding]; other site 251221009826 activation loop (A-loop); other site 251221009827 TolB amino-terminal domain; Region: TolB_N; cl00639 251221009828 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 251221009829 binding surface 251221009830 TPR motif; other site 251221009831 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 251221009832 binding surface 251221009833 TPR motif; other site 251221009834 Putative Zn-dependent protease, contains TPR repeats [General function prediction only]; Region: COG4783 251221009835 Transposase; Region: HTH_Tnp_IS630; pfam01710 251221009836 Integrase core domain; Region: rve; cl01316 251221009837 YhcR_OBF_like: A subfamily of OB-fold domains similar to the OB folds of Bacillus subtilis YhcR. YhcR is a sugar-nonspecific nuclease, which is active in the presence of Ca2+ and Mn2+. It cleaves RNA endonucleolytically, producing 3'-monophosphate...; Region: YhcR_OBF_like; cd04486 251221009838 generic binding surface II; other site 251221009839 generic binding surface I; other site 251221009840 Mycoplasma pulmonis MnuA nuclease-like; Region: MnuA_DNase1-like; cd10283 251221009841 putative active site [active] 251221009842 putative catalytic site [active] 251221009843 putative Mg binding site IVb [ion binding]; other site 251221009844 putative phosphate binding site [ion binding]; other site 251221009845 putative DNA binding site [nucleotide binding]; other site 251221009846 putative Mg binding site IVa [ion binding]; other site 251221009847 cardiolipin synthetase; Reviewed; Region: cls; PRK01642 251221009848 Putative catalytic domain, repeat 1, of Pseudomonas aeruginosa cardiolipin synthase and similar proteins; Region: PLDc_PaCLS_like_1; cd09155 251221009849 putative active site [active] 251221009850 catalytic site [active] 251221009851 Putative catalytic domain, repeat 2, of Pseudomonas aeruginosa cardiolipin synthase and similar proteins; Region: PLDc_PaCLS_like_2; cd09161 251221009852 putative active site [active] 251221009853 catalytic site [active] 251221009854 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 251221009855 putative catalytic site [active] 251221009856 putative metal binding site [ion binding]; other site 251221009857 putative phosphate binding site [ion binding]; other site 251221009858 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 251221009859 putative active site [active] 251221009860 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 251221009861 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 251221009862 HIGH motif; other site 251221009863 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 251221009864 active site 251221009865 KMSKS motif; other site 251221009866 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 251221009867 tRNA binding surface [nucleotide binding]; other site 251221009868 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 251221009869 DNA primase; Validated; Region: dnaG; PRK05667 251221009870 CHC2 zinc finger; Region: zf-CHC2; cl15369 251221009871 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 251221009872 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 251221009873 active site 251221009874 metal binding site [ion binding]; metal-binding site 251221009875 interdomain interaction site; other site 251221009876 aconitate hydratase; Validated; Region: PRK07229 251221009877 Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: AcnA_Bact; cd01585 251221009878 substrate binding site [chemical binding]; other site 251221009879 ligand binding site [chemical binding]; other site 251221009880 Bacterial Aconitase-like swivel domain. Aconitase (aconitate hydratase or citrate hydrolyase) catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle. Cis-aconitate is formed as an intermediate product during the course...; Region: AcnA_Bact_Swivel; cd01579 251221009881 substrate binding site [chemical binding]; other site 251221009882 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 251221009883 binding surface 251221009884 TPR motif; other site 251221009885 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 251221009886 putative active site [active] 251221009887 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 251221009888 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 251221009889 binding surface 251221009890 TPR motif; other site 251221009891 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 251221009892 binding surface 251221009893 TPR motif; other site 251221009894 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 251221009895 binding surface 251221009896 TPR motif; other site 251221009897 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 251221009898 binding surface 251221009899 TPR motif; other site 251221009900 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 251221009901 binding surface 251221009902 TPR motif; other site 251221009903 Predicted acetyltransferases and hydrolases with the alpha/beta hydrolase fold [General function prediction only]; Region: LipA; COG1075 251221009904 Ribbon-helix-helix protein, copG family; Region: RHH_1; cl15375 251221009905 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 251221009906 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 251221009907 active site 251221009908 phosphorylation site [posttranslational modification] 251221009909 intermolecular recognition site; other site 251221009910 dimerization interface [polypeptide binding]; other site 251221009911 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 251221009912 DNA binding residues [nucleotide binding] 251221009913 dimerization interface [polypeptide binding]; other site 251221009914 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 251221009915 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 251221009916 ATP binding site [chemical binding]; other site 251221009917 Mg2+ binding site [ion binding]; other site 251221009918 G-X-G motif; other site 251221009919 Protein of unknown function (DUF4255); Region: DUF4255; pfam14065 251221009920 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383 251221009921 Phage tail sheath protein; Region: Phage_sheath_1; cl01389 251221009922 Phage tail sheath protein; Region: Phage_sheath_1; cl01389 251221009923 T4-like virus tail tube protein gp19; Region: Phage_T4_gp19; cl12125 251221009924 T4-like virus tail tube protein gp19; Region: Phage_T4_gp19; cl12125 251221009925 T4-like virus tail tube protein gp19; Region: Phage_T4_gp19; cl12125 251221009926 Mu-like prophage FluMu protein gp41; Region: FluMu_gp41; pfam10109 251221009927 Catalytic domain of Protein Kinases; Region: PKc; cd00180 251221009928 active site 251221009929 ATP binding site [chemical binding]; other site 251221009930 substrate binding site [chemical binding]; other site 251221009931 activation loop (A-loop); other site 251221009932 LL-diaminopimelate aminotransferase; Provisional; Region: PRK09276 251221009933 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 251221009934 pyridoxal 5'-phosphate binding site [chemical binding]; other site 251221009935 homodimer interface [polypeptide binding]; other site 251221009936 catalytic residue [active] 251221009937 S-layer homology domain; Region: SLH; pfam00395 251221009938 S-layer homology domain; Region: SLH; pfam00395 251221009939 S-layer homology domain; Region: SLH; pfam00395 251221009940 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 251221009941 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD_like; cd08296 251221009942 putative NAD(P) binding site [chemical binding]; other site 251221009943 putative substrate binding site [chemical binding]; other site 251221009944 catalytic Zn binding site [ion binding]; other site 251221009945 structural Zn binding site [ion binding]; other site 251221009946 S-layer homology domain; Region: SLH; pfam00395 251221009947 S-layer homology domain; Region: SLH; pfam00395 251221009948 S-layer homology domain; Region: SLH; pfam00395 251221009949 FG-GAP repeat; Region: FG-GAP; cl15299 251221009950 ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127 251221009951 ABC (ATP-binding cassette) transport system involved in resistant to organic solvents; ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars, ions, peptides, and more complex...; Region: ABC_Org_Solvent_Resistant; cd03261 251221009952 Walker A/P-loop; other site 251221009953 ATP binding site [chemical binding]; other site 251221009954 Q-loop/lid; other site 251221009955 ABC transporter signature motif; other site 251221009956 Walker B; other site 251221009957 D-loop; other site 251221009958 H-loop/switch region; other site 251221009959 mce related protein; Region: MCE; cl15431 251221009960 Plasmid stabilisation system protein; Region: Plasmid_stabil; cl11422 251221009961 Uncharacterised protein family (UPF0156); Region: RHH_2; cl01448 251221009962 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 251221009963 FG-GAP repeat; Region: FG-GAP; cl15299 251221009964 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 251221009965 putative active site [active] 251221009966 oligopeptide ABC transporter ATP-binding protein OppF; Provisional; Region: PRK15079 251221009967 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 251221009968 Walker A/P-loop; other site 251221009969 ATP binding site [chemical binding]; other site 251221009970 Q-loop/lid; other site 251221009971 ABC transporter signature motif; other site 251221009972 Walker B; other site 251221009973 D-loop; other site 251221009974 H-loop/switch region; other site 251221009975 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 251221009976 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 251221009977 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 251221009978 Walker A/P-loop; other site 251221009979 ATP binding site [chemical binding]; other site 251221009980 Q-loop/lid; other site 251221009981 ABC transporter signature motif; other site 251221009982 Walker B; other site 251221009983 D-loop; other site 251221009984 H-loop/switch region; other site 251221009985 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 251221009986 oligopeptide ABC transporter permease OppC; Provisional; Region: PRK15406 251221009987 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 251221009988 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 251221009989 dimer interface [polypeptide binding]; other site 251221009990 conserved gate region; other site 251221009991 putative PBP binding loops; other site 251221009992 ABC-ATPase subunit interface; other site 251221009993 oligopeptide transporter permease; Reviewed; Region: oppB; PRK09471 251221009994 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 251221009995 dimer interface [polypeptide binding]; other site 251221009996 conserved gate region; other site 251221009997 putative PBP binding loops; other site 251221009998 ABC-ATPase subunit interface; other site 251221009999 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 251221010000 Type 1 glutamine amidotransferase (GATase1)-like domain found in cyanophycinase; Region: GAT1_cyanophycinase; cd03145 251221010001 proposed catalytic triad [active] 251221010002 active site nucleophile [active] 251221010003 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 251221010004 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 251221010005 active site 251221010006 phosphorylation site [posttranslational modification] 251221010007 intermolecular recognition site; other site 251221010008 dimerization interface [polypeptide binding]; other site 251221010009 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 251221010010 DNA binding site [nucleotide binding] 251221010011 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641 251221010012 Ribonuclease BN-like family; Region: Ribonuclease_BN; cl07918 251221010013 ATP-dependent protease La (LON) domain; Region: LON; pfam02190 251221010014 hydrogenase nickel incorporation protein; Provisional; Region: hypA; PRK03824 251221010015 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 251221010016 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 251221010017 MTABC3 (also known as ABCB6) is a mitochondrial ATP-binding cassette protein involved in iron homeostasis and one of four ABC transporters expressed in the mitochondrial inner membrane, the other three being MDL1(ABC7), MDL2, and ATM1. In fact, the...; Region: ABC_MTABC3_MDL1_MDL2; cd03249 251221010018 Walker A/P-loop; other site 251221010019 ATP binding site [chemical binding]; other site 251221010020 Q-loop/lid; other site 251221010021 ABC transporter signature motif; other site 251221010022 Walker B; other site 251221010023 D-loop; other site 251221010024 H-loop/switch region; other site 251221010025 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 251221010026 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 251221010027 binding surface 251221010028 TPR motif; other site 251221010029 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 251221010030 binding surface 251221010031 TPR motif; other site 251221010032 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 251221010033 binding surface 251221010034 TPR motif; other site 251221010035 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 251221010036 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 251221010037 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 251221010038 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 251221010039 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 251221010040 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 251221010041 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 251221010042 NaMN:DMB phosphoribosyltransferase [Coenzyme metabolism]; Region: CobT; COG2038 251221010043 Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (DMB-PRT), also called CobT; Region: DMB-PRT_CobT; cd02439 251221010044 active site pocket [active] 251221010045 Calpains, domains IIa, IIb; calcium-dependent cytoplasmic cysteine proteinases, papain-like. Functions in cytoskeletal remodeling processes, cell differentiation, apoptosis and signal transduction; Region: CysPc; cl00051 251221010046 catalytic site [active] 251221010047 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 251221010048 dimer interface [polypeptide binding]; other site 251221010049 conserved gate region; other site 251221010050 putative PBP binding loops; other site 251221010051 ABC-ATPase subunit interface; other site 251221010052 GTP-binding protein HflX; Region: GTP_HflX; TIGR03156 251221010053 HflX subfamily. A distinct conserved domain with a glycine-rich segment N-terminal of the GTPase domain characterizes the HflX subfamily. The E. coli HflX has been implicated in the control of the lambda cII repressor proteolysis, but the actual...; Region: HflX; cd01878 251221010054 G1 box; other site 251221010055 GTP/Mg2+ binding site [chemical binding]; other site 251221010056 Switch I region; other site 251221010057 G2 box; other site 251221010058 G3 box; other site 251221010059 Switch II region; other site 251221010060 G4 box; other site 251221010061 G5 box; other site 251221010062 Transcriptional accessory protein [Transcription]; Region: Tex; COG2183 251221010063 Tex-like protein N-terminal domain; Region: Tex_N; pfam09371 251221010064 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD includes...; Region: RuvC_resolvase; cl00243 251221010065 S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685 251221010066 RNA binding site [nucleotide binding]; other site 251221010067 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_1; cd09606 251221010068 oligoendopeptidase, M3 family; Region: M3_not_pepF; TIGR02289 251221010069 active site 251221010070 Zn binding site [ion binding]; other site 251221010071 Acetoacetate decarboxylase (ADC); Region: ADC; cl01919 251221010072 Member of the Rhodanese Homology Domain superfamily, subgroup 2. Subgroup 2 includes uncharacterized putative rhodanese-related domains; Region: RHOD_2; cd01528 251221010073 active site residue [active] 251221010074 Rho termination factor, N-terminal domain; Region: Rho_N; cl06505 251221010075 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3330 251221010076 Uncharacterized conserved protein [Function unknown]; Region: COG1543 251221010077 Domain of unknown function (DUF1957); Region: DUF1957; pfam09210 251221010078 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 251221010079 putative active site [active] 251221010080 Zn-finger in ubiquitin-hydrolases and other protein; Region: zf-UBP; cl09957 251221010081 Zn-finger in ubiquitin-hydrolases and other protein; Region: zf-UBP; cl09957 251221010082 hopanoid-associated sugar epimerase; Region: HpnA; TIGR03466 251221010083 uncharacterized subgroup of aldehyde reductase and flavonoid reductase related proteins, extended (e) SDRs; Region: AR_FR_like_1_SDR_e; cd05228 251221010084 putative NADP binding site [chemical binding]; other site 251221010085 putative substrate binding site [chemical binding]; other site 251221010086 active site 251221010087 Helix-turn-helix domains; Region: HTH; cl00088 251221010088 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 251221010089 Domain of unknown function DUF29; Region: DUF29; pfam01724 251221010090 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 251221010091 metal binding site [ion binding]; metal-binding site 251221010092 active site 251221010093 I-site; other site 251221010094 Response regulator receiver domain; Region: Response_reg; pfam00072 251221010095 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 251221010096 active site 251221010097 phosphorylation site [posttranslational modification] 251221010098 intermolecular recognition site; other site 251221010099 dimerization interface [polypeptide binding]; other site 251221010100 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 251221010101 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 251221010102 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 251221010103 dimer interface [polypeptide binding]; other site 251221010104 phosphorylation site [posttranslational modification] 251221010105 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 251221010106 ATP binding site [chemical binding]; other site 251221010107 Mg2+ binding site [ion binding]; other site 251221010108 G-X-G motif; other site 251221010109 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 251221010110 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 251221010111 active site 251221010112 phosphorylation site [posttranslational modification] 251221010113 intermolecular recognition site; other site 251221010114 dimerization interface [polypeptide binding]; other site 251221010115 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 251221010116 DNA binding site [nucleotide binding] 251221010117 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 251221010118 Predicted P-loop-containing kinase [General function prediction only]; Region: COG1660 251221010119 family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187 251221010120 Uncharacterised protein family UPF0052; Region: UPF0052; pfam01933 251221010121 phosphate binding site [ion binding]; other site 251221010122 putative substrate binding pocket [chemical binding]; other site 251221010123 dimer interface [polypeptide binding]; other site 251221010124 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_3; cd07820 251221010125 putative hydrophobic ligand binding site [chemical binding]; other site 251221010126 preprotein translocase subunit SecD; Reviewed; Region: secD; PRK05812 251221010127 Protein export membrane protein; Region: SecD_SecF; cl14618 251221010128 preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022 251221010129 Protein export membrane protein; Region: SecD_SecF; cl14618 251221010130 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 251221010131 Ligand Binding Site [chemical binding]; other site 251221010132 Cation efflux family; Region: Cation_efflux; cl00316 251221010133 Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696 251221010134 Membrane Fusion Protein cluster 2 (function with RND porters); Region: 8a0102; TIGR00999 251221010135 Helix-turn-helix domains; Region: HTH; cl00088 251221010136 Peptidase family M48; Region: Peptidase_M48; cl12018 251221010137 Uncharacterised BCR, YnfA/UPF0060 family; Region: UPF0060; cl00757 251221010138 EamA-like transporter family; Region: EamA; cl01037 251221010139 Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661 251221010140 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: APH_ChoK_like; cl15691 251221010141 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: APH_ChoK_like; cl15691 251221010142 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 251221010143 anti sigma factor interaction site; other site 251221010144 regulatory phosphorylation site [posttranslational modification]; other site 251221010145 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cl00258 251221010146 rRNA methylase, putative, group 3; Region: rRNA_methyl_3; TIGR00186 251221010147 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; cl06870 251221010148 SpoU rRNA Methylase family; Region: SpoU_methylase; cl00362 251221010149 ClC chloride channel EriC. This domain is found in the EriC chloride transporters that mediate the extreme acid resistance response in eubacteria and archaea. This response allows bacteria to survive in the acidic environments by decarboxylation-linked...; Region: EriC; cd01031 251221010150 Voltage gated chloride channel; Region: Voltage_CLC; pfam00654 251221010151 Cl- selectivity filter; other site 251221010152 Cl- binding residues [ion binding]; other site 251221010153 pore gating glutamate residue; other site 251221010154 dimer interface [polypeptide binding]; other site 251221010155 H+/Cl- coupling transport residue; other site 251221010156 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with either the SpoIVFB domain (sporulation protein, stage IV cell wall formation, F locus, promoter-distal B) or the chloride channel protein EriC; Region: CBS_pair_SpoIVFB_EriC_assoc; cd04612 251221010157 The C-terminal domain of a subfamily of Na+ /H+ antiporter existed in bacteria and archea . Na+/H+ exchange proteins eject protons from cells, effectively eliminating excess acid from actively metabolising cells. Na+ /H+ exchange activity is also crucial...; Region: Na_H_Antiporter_C; cd01988 251221010158 Ligand Binding Site [chemical binding]; other site 251221010159 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 251221010160 Ligand Binding Site [chemical binding]; other site 251221010161 Domain of unknown function (DUF4145); Region: DUF4145; pfam13643 251221010162 Domain of unknown function (DUF1823); Region: DUF1823; pfam08853 251221010163 Enoyl-[acyl-carrier-protein]; Region: FabI; COG0623 251221010164 Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372 251221010165 NAD binding site [chemical binding]; other site 251221010166 homotetramer interface [polypeptide binding]; other site 251221010167 homodimer interface [polypeptide binding]; other site 251221010168 substrate binding site [chemical binding]; other site 251221010169 active site 251221010170 CutA1 divalent ion tolerance protein; Region: CutA1; cl00584 251221010171 Transposase domain (DUF772); Region: DUF772; cl15789 251221010172 Transposase, Mutator family; Region: Transposase_mut; pfam00872 251221010173 Transposase, Mutator family; Region: Transposase_mut; pfam00872 251221010174 MULE transposase domain; Region: MULE; pfam10551 251221010175 Sirohydrochlorin ferrochelatase [Inorganic ion transport and metabolism]; Region: COG2138 251221010176 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_N; cd03416 251221010177 putative active site [active] 251221010178 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), C-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_C; cd03414 251221010179 putative active site [active] 251221010180 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 251221010181 dimer interface [polypeptide binding]; other site 251221010182 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 251221010183 trigger factor; Provisional; Region: tig; PRK01490 251221010184 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; cl11587 251221010185 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 251221010186 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 251221010187 ClpX C4-type zinc finger; Region: zf-C4_ClpX; cl05964 251221010188 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 251221010189 Walker A motif; other site 251221010190 ATP binding site [chemical binding]; other site 251221010191 Walker B motif; other site 251221010192 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; cl11083 251221010193 Neurotransmitter-gated ion-channel ligand binding domain; Region: Neur_chan_LBD; pfam02931 251221010194 Neurotransmitter-gated ion-channel transmembrane region; Region: Neur_chan_memb; pfam02932 251221010195 Acyl-protein synthetase, LuxE; Region: LuxE; cl15695 251221010196 Beta-propeller repeat; Region: SBBP; pfam06739 251221010197 Beta-propeller repeat; Region: SBBP; pfam06739 251221010198 Beta-propeller repeat; Region: SBBP; pfam06739 251221010199 Beta-propeller repeat; Region: SBBP; pfam06739 251221010200 Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes [Energy production and conversion]; Region: Lpd; COG1249 251221010201 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 251221010202 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 251221010203 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 251221010204 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 251221010205 tetrahydroxynaphthalene/trihydroxynaphthalene reductase-like, classical (c) SDRs; Region: THN_reductase-like_SDR_c; cd05362 251221010206 NADP binding site [chemical binding]; other site 251221010207 homodimer interface [polypeptide binding]; other site 251221010208 active site 251221010209 substrate binding site [chemical binding]; other site 251221010210 Helix-turn-helix domains; Region: HTH; cl00088 251221010211 Protein of unknown function (DUF2281); Region: DUF2281; cl02355 251221010212 Signal peptide peptidase A (SppA) 67K type, a serine protease, has catalytic Ser-Lys dyad; Region: S49_SppA_67K_type; cd07018 251221010213 tandem repeat interface [polypeptide binding]; other site 251221010214 oligomer interface [polypeptide binding]; other site 251221010215 active site residues [active] 251221010216 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 251221010217 tandem repeat interface [polypeptide binding]; other site 251221010218 oligomer interface [polypeptide binding]; other site 251221010219 active site residues [active] 251221010220 Protein of unknown function (DUF433); Region: DUF433; cl01030 251221010221 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 251221010222 This family of ATP-binding proteins belongs to a multisubunit transporter involved in drug resistance (BcrA and DrrA), nodulation, lipid transport, and lantibiotic immunity. In bacteria and archaea, these transporters usually include an ATP-binding...; Region: ABC_DR_subfamily_A; cd03230 251221010223 Walker A/P-loop; other site 251221010224 ATP binding site [chemical binding]; other site 251221010225 Q-loop/lid; other site 251221010226 ABC transporter signature motif; other site 251221010227 Walker B; other site 251221010228 D-loop; other site 251221010229 H-loop/switch region; other site 251221010230 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 251221010231 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 251221010232 active site 251221010233 phosphorylation site [posttranslational modification] 251221010234 intermolecular recognition site; other site 251221010235 dimerization interface [polypeptide binding]; other site 251221010236 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 251221010237 DNA binding site [nucleotide binding] 251221010238 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cl00086 251221010239 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 251221010240 active site 251221010241 phosphorylation site [posttranslational modification] 251221010242 intermolecular recognition site; other site 251221010243 dimerization interface [polypeptide binding]; other site 251221010244 Response regulator receiver domain; Region: Response_reg; pfam00072 251221010245 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 251221010246 active site 251221010247 phosphorylation site [posttranslational modification] 251221010248 intermolecular recognition site; other site 251221010249 dimerization interface [polypeptide binding]; other site 251221010250 PAS domain S-box; Region: sensory_box; TIGR00229 251221010251 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 251221010252 putative active site [active] 251221010253 heme pocket [chemical binding]; other site 251221010254 Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal transduction mechanisms]; Region: COG4191 251221010255 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 251221010256 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 251221010257 putative active site [active] 251221010258 heme pocket [chemical binding]; other site 251221010259 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 251221010260 dimer interface [polypeptide binding]; other site 251221010261 phosphorylation site [posttranslational modification] 251221010262 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 251221010263 ATP binding site [chemical binding]; other site 251221010264 Mg2+ binding site [ion binding]; other site 251221010265 G-X-G motif; other site 251221010266 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl09944 251221010267 active site 251221010268 phosphorylation site [posttranslational modification] 251221010269 intermolecular recognition site; other site 251221010270 dimerization interface [polypeptide binding]; other site 251221010271 Response regulator receiver domain; Region: Response_reg; pfam00072 251221010272 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 251221010273 active site 251221010274 phosphorylation site [posttranslational modification] 251221010275 intermolecular recognition site; other site 251221010276 dimerization interface [polypeptide binding]; other site 251221010277 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 251221010278 Ligand Binding Site [chemical binding]; other site 251221010279 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 251221010280 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; cl02930 251221010281 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 251221010282 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 251221010283 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 251221010284 Family description; Region: VCBS; pfam13517 251221010285 Family description; Region: VCBS; pfam13517 251221010286 Family description; Region: VCBS; pfam13517 251221010287 Family description; Region: VCBS; pfam13517 251221010288 Family description; Region: VCBS; pfam13517 251221010289 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5267 251221010290 Protein of unknown function (DUF1800); Region: DUF1800; pfam08811 251221010291 Protein of unknown function (DUF1501); Region: DUF1501; pfam07394 251221010292 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 251221010293 putative active site [active] 251221010294 Sulfatase; Region: Sulfatase; cl10460 251221010295 Phosphopantetheine attachment site; Region: PP-binding; cl09936 251221010296 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 251221010297 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 251221010298 active site 251221010299 Acyl transferase domain; Region: Acyl_transf_1; cl08282 251221010300 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 251221010301 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; cl00500 251221010302 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; cl00500 251221010303 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl09108 251221010304 phosphate binding site [ion binding]; other site 251221010305 2-Nitropropane dioxygenase (NPD)-like domain, associated with polyketide synthases (PKS). NPD is part of the nitroalkaneoxidizing enzyme family, that catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and...; Region: NPD_PKS; cd04743 251221010306 putative enoyl-[acyl-carrier-protein] reductase II; Region: enACPred_II; TIGR03151 251221010307 FMN binding site [chemical binding]; other site 251221010308 substrate binding site [chemical binding]; other site 251221010309 putative catalytic residue [active] 251221010310 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 251221010311 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 251221010312 active site 251221010313 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 251221010314 Acyl transferase domain; Region: Acyl_transf_1; cl08282 251221010315 polyketide-type polyunsaturated fatty acid synthase PfaA; Region: omega_3_PfaA; TIGR02813 251221010316 Phosphopantetheine attachment site; Region: PP-binding; cl09936 251221010317 Phosphopantetheine attachment site; Region: PP-binding; cl09936 251221010318 Phosphopantetheine attachment site; Region: PP-binding; cl09936 251221010319 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 251221010320 putative NADP binding site [chemical binding]; other site 251221010321 active site 251221010322 Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412 251221010323 dimer interface [polypeptide binding]; other site 251221010324 substrate binding site [chemical binding]; other site 251221010325 metal binding sites [ion binding]; metal-binding site 251221010326 Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919 251221010327 tetramerization interface [polypeptide binding]; other site 251221010328 active site 251221010329 Cellulose synthase catalytic subunit A2 (CESA2) is a catalytic subunit or a catalytic subunit substitute of the cellulose synthase complex; Region: CESA_CaSu_A2; cd06437 251221010330 DXD motif; other site 251221010331 isoform II; Region: PAF-AH_p_II; pfam03403 251221010332 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 251221010333 translocation protein TolB; Provisional; Region: tolB; PRK01029 251221010334 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 251221010335 The excision repair protein UvrA domain I; Nucleotide excision repair in eubacteria is a process that repairs DNA damage by the removal of a 12-13-mer oligonucleotide containing the lesion. Recognition and cleavage of the damaged DNA is a multistep...; Region: ABC_UvrA_I; cd03270 251221010336 The excision repair protein UvrA domain I; Nucleotide excision repair in eubacteria is a process that repairs DNA damage by the removal of a 12-13-mer oligonucleotide containing the lesion. Recognition and cleavage of the damaged DNA is a multistep...; Region: ABC_UvrA_I; cd03270 251221010337 The excision repair protein UvrA domain II; Nucleotide excision repair in eubacteria is a process that repairs DNA damage by the removal of a 12-13-mer oligonucleotide containing the lesion. Recognition and cleavage of the damaged DNA is a multistep...; Region: ABC_UvrA_II; cd03271 251221010338 Ribbon-helix-helix protein, copG family; Region: RHH_1; cl15375 251221010339 Plasmid stabilisation system protein; Region: Plasmid_stabil; cl11422 251221010340 Fe-S oxidoreductase [Energy production and conversion]; Region: COG1032 251221010341 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 251221010342 B12 binding site [chemical binding]; other site 251221010343 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 251221010344 FeS/SAM binding site; other site 251221010345 Endonuclease_V, a DNA repair enzyme that initiates repair of nitrosative deaminated purine bases; Region: Endonuclease_V; cd06559 251221010346 Active_site [active] 251221010347 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 251221010348 hypothetical protein; Provisional; Region: PRK07208 251221010349 GtrA-like protein; Region: GtrA; cl00971 251221010350 Protein of unknown function (DUF2808); Region: DUF2808; pfam10989 251221010351 Uncharacterised protein family (UPF0227); Region: UPF0227; cl14886 251221010352 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 251221010353 Beta-propeller repeat; Region: SBBP; pfam06739 251221010354 Beta-propeller repeat; Region: SBBP; pfam06739 251221010355 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 251221010356 HSP70 interaction site [polypeptide binding]; other site 251221010357 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 251221010358 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 251221010359 Na+/melibiose symporter and related transporters [Carbohydrate transport and metabolism]; Region: MelB; COG2211 251221010360 melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392 251221010361 Glyoxal oxidase N-terminus; Region: Glyoxal_oxid_N; pfam07250 251221010362 kelch-like protein; Provisional; Region: PHA03098 251221010363 Kelch motif; Region: Kelch_1; cl02701 251221010364 C-terminal Early set domain associated with the catalytic domain of galactose oxidase; Region: E_set_GO_C; cd02851 251221010365 FG-GAP repeat; Region: FG-GAP; cl15299 251221010366 Predicted transcriptional regulators [Transcription]; Region: COG1725 251221010367 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 251221010368 DNA-binding site [nucleotide binding]; DNA binding site 251221010369 Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917 251221010370 NodB motif; other site 251221010371 active site 251221010372 catalytic site [active] 251221010373 metal binding site [ion binding]; metal-binding site 251221010374 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 251221010375 Helix-turn-helix domains; Region: HTH; cl00088 251221010376 Domain of unknown function (DUF955); Region: DUF955; cl01076 251221010377 Predicted nucleic acid-binding protein, contains PIN domain [General function prediction only]; Region: COG2405 251221010378 dimethyl sulfone monooxygenase SfnG; Region: LLM_DMSO2_sfnG; TIGR04021 251221010379 Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094 251221010380 active site 251221010381 dimer interface [polypeptide binding]; other site 251221010382 non-prolyl cis peptide bond; other site 251221010383 insertion regions; other site 251221010384 D-alanine--D-alanine ligase; Reviewed; Region: ddl; PRK01372 251221010385 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087 251221010386 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 251221010387 glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK02862 251221010388 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 251221010389 ligand binding site; other site 251221010390 oligomer interface; other site 251221010391 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 251221010392 dimer interface [polypeptide binding]; other site 251221010393 N-terminal domain interface [polypeptide binding]; other site 251221010394 sulfate 1 binding site; other site 251221010395 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 251221010396 TPR motif; other site 251221010397 binding surface 251221010398 Rhomboid family; Region: Rhomboid; cl11446 251221010399 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 251221010400 Polysaccharide lyase; Region: Polysacc_lyase; pfam14099 251221010401 Domain of unknown function (DUF4330); Region: DUF4330; pfam14221 251221010402 chaperone protein DnaJ; Provisional; Region: PRK14293 251221010403 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 251221010404 HSP70 interaction site [polypeptide binding]; other site 251221010405 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262 251221010406 substrate binding site [polypeptide binding]; other site 251221010407 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 251221010408 Zn binding sites [ion binding]; other site 251221010409 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 251221010410 dimer interface [polypeptide binding]; other site 251221010411 GTPase RsgA; Reviewed; Region: PRK12289 251221010412 YjeQ/EngC. YjeQ (YloQ in Bacillus subtilis) represents a protein family whose members are broadly conserved in bacteria and have been shown to be essential to the growth of E. coli and B. subtilis. Proteins of the YjeQ family contain all sequence motifs...; Region: YjeQ_engC; cd01854 251221010413 GTPase/OB domain interface [polypeptide binding]; other site 251221010414 GTPase/Zn-binding domain interface [polypeptide binding]; other site 251221010415 GTP/Mg2+ binding site [chemical binding]; other site 251221010416 G4 box; other site 251221010417 G5 box; other site 251221010418 G1 box; other site 251221010419 Switch I region; other site 251221010420 G2 box; other site 251221010421 G3 box; other site 251221010422 Switch II region; other site 251221010423 bacterial and archael members of the sulfite oxidase (SO) family of molybdopterin binding domains. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and...; Region: arch_bact_SO_family_Moco; cd02109 251221010424 Moco binding site; other site 251221010425 metal coordination site [ion binding]; other site 251221010426 Entner-Doudoroff aldolase; Region: eda; TIGR01182 251221010427 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 251221010428 active site 251221010429 intersubunit interface [polypeptide binding]; other site 251221010430 catalytic residue [active] 251221010431 MAPEG family; Region: MAPEG; cl09190 251221010432 Fasciclin domain; Region: Fasciclin; cl02663 251221010433 Sulfotransferase family; Region: Sulfotransfer_3; cl14559 251221010434 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 251221010435 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 251221010436 putative PBP binding loops; other site 251221010437 ABC-ATPase subunit interface; other site 251221010438 Phosphoribosyl transferase domain; Region: Pribosyltran; cl00309 251221010439 DNA-directed RNA polymerase subunit gamma; Provisional; Region: rpoC1; PRK02625 251221010440 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 251221010441 RNA polymerase Rpb1, domain 2; Region: RNA_pol_Rpb1_2; cl11591 251221010442 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 251221010443 DNA-directed RNA polymerase subunit beta'; Provisional; Region: rpoC2; PRK02597 251221010444 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 251221010445 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 251221010446 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 251221010447 Rpb1 - Rpb6 interaction site [polypeptide binding]; other site 251221010448 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 251221010449 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 251221010450 DNA binding site [nucleotide binding] 251221010451 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 251221010452 arginyl-tRNA synthetase; Reviewed; Region: argS; PRK01611 251221010453 Arginyl tRNA synthetase N terminal domain; Region: Arg_tRNA_synt_N; cl04104 251221010454 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 251221010455 active site 251221010456 HIGH motif; other site 251221010457 KMSK motif region; other site 251221010458 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 251221010459 tRNA binding surface [nucleotide binding]; other site 251221010460 anticodon binding site; other site 251221010461 Predicted divalent heavy-metal cations transporter [Inorganic ion transport and metabolism]; Region: COG0428; cl00437 251221010462 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 251221010463 sulfate ABC transporter, ATP-binding protein; Region: 3a0106s01; TIGR00968 251221010464 Walker A/P-loop; other site 251221010465 ATP binding site [chemical binding]; other site 251221010466 Q-loop/lid; other site 251221010467 ABC transporter signature motif; other site 251221010468 Walker B; other site 251221010469 D-loop; other site 251221010470 H-loop/switch region; other site 251221010471 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 251221010472 dimer interface [polypeptide binding]; other site 251221010473 conserved gate region; other site 251221010474 putative PBP binding loops; other site 251221010475 ABC-ATPase subunit interface; other site 251221010476 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 251221010477 TOBE domain; Region: TOBE_2; cl01440 251221010478 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl14000 251221010479 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cl00214 251221010480 intersubunit interface [polypeptide binding]; other site 251221010481 active site 251221010482 Zn2+ binding site [ion binding]; other site 251221010483 Protein of unknown function (DUF1092); Region: DUF1092; pfam06485 251221010484 Ycf46; Provisional; Region: ycf46; CHL00195 251221010485 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 251221010486 Walker A motif; other site 251221010487 ATP binding site [chemical binding]; other site 251221010488 Walker B motif; other site 251221010489 arginine finger; other site 251221010490 Protein of unknown function (DUF1257); Region: DUF1257; cl06088 251221010491 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 251221010492 putative active site [active] 251221010493 DPS-like protein, ferritin-like diiron-binding domain; Region: DPSL; cd01052 251221010494 Ferritin-like domain; Region: Ferritin; pfam00210 251221010495 diiron binding motif [ion binding]; other site 251221010496 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 251221010497 iron-sulfur cluster [ion binding]; other site 251221010498 [2Fe-2S] cluster binding site [ion binding]; other site 251221010499 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 251221010500 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 251221010501 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 251221010502 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 251221010503 homoserine dehydrogenase; Provisional; Region: PRK06349 251221010504 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 251221010505 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 251221010506 ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881 251221010507 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 251221010508 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl00284 251221010509 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 251221010510 ligand-binding site [chemical binding]; other site 251221010511 37-kD nucleoid-associated bacterial protein; Region: NA37; cl15473 251221010512 This family is most closely related to the GT1 family of glycosyltransferases. wcfI in Bacteroides fragilis has been shown to be involved in the capsular polysaccharide biosynthesis; Region: GT1_wcfI_like; cd03825 251221010513 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 251221010514 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 251221010515 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl12011 251221010516 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 251221010517 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 251221010518 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 251221010519 active site 251221010520 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 251221010521 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 251221010522 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 251221010523 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl12011 251221010524 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 251221010525 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 251221010526 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl12011 251221010527 Uncharacterized protein involved in exopolysaccharide biosynthesis [Cell envelope biogenesis, outer membrane]; Region: GumC; COG3206 251221010528 Chain length determinant protein; Region: Wzz; cl01623 251221010529 tyrosine kinase; Provisional; Region: PRK11519 251221010530 Chain length determinant protein; Region: Wzz; cl01623 251221010531 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 251221010532 This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809 251221010533 Domain of unknown function (DUF4415); Region: DUF4415; cl01401 251221010534 Protein of unknown function (DUF2930); Region: DUF2930; pfam11152 251221010535 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 251221010536 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 251221010537 substrate binding site [chemical binding]; other site 251221010538 glutamase interaction surface [polypeptide binding]; other site 251221010539 NADH:ubiquinone oxidoreductase 27 kD subunit [Energy production and conversion]; Region: NuoC; cl00365 251221010540 F0F1 ATP synthase subunit gamma; Provisional; Region: PRK13422 251221010541 Domain of unknown function (DUF1830); Region: DUF1830; pfam08865 251221010542 ribosomal protein S12 methylthiotransferase RimO; Region: TIGR01125 251221010543 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 251221010544 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 251221010545 FeS/SAM binding site; other site 251221010546 hypothetical protein; Validated; Region: PRK07413 251221010547 ATP:corrinoid adenosyltransferase BtuR/CobO/CobP. This family consists of the BtuR, CobO, CobP proteins all of which are Cob(I)alamin (vitamin B12) adenosyltransferase, which is involved in cobalamin (vitamin B12) biosynthesis. This enzyme is a homodimer; Region: CobA_CobO_BtuR; cd00561 251221010548 Walker A motif; other site 251221010549 homodimer interface [polypeptide binding]; other site 251221010550 ATP binding site [chemical binding]; other site 251221010551 hydroxycobalamin binding site [chemical binding]; other site 251221010552 Walker B motif; other site 251221010553 ATP:corrinoid adenosyltransferase BtuR/CobO/CobP. This family consists of the BtuR, CobO, CobP proteins all of which are Cob(I)alamin (vitamin B12) adenosyltransferase, which is involved in cobalamin (vitamin B12) biosynthesis. This enzyme is a homodimer; Region: CobA_CobO_BtuR; cd00561 251221010554 Walker A motif; other site 251221010555 homodimer interface [polypeptide binding]; other site 251221010556 ATP binding site [chemical binding]; other site 251221010557 hydroxycobalamin binding site [chemical binding]; other site 251221010558 Walker B motif; other site 251221010559 FOG: HEAT repeat [Energy production and conversion]; Region: COG1413 251221010560 Transposase domain (DUF772); Region: DUF772; cl12084 251221010561 Transglutaminase-like superfamily; Region: Transglut_core; cl10469 251221010562 Small Multidrug Resistance protein; Region: Multi_Drug_Res; cl00910 251221010563 formyltetrahydrofolate deformylase; Reviewed; Region: purU; PRK06027 251221010564 N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875 251221010565 Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648 251221010566 putative active site [active] 251221010567 putative substrate binding site [chemical binding]; other site 251221010568 putative cosubstrate binding site; other site 251221010569 catalytic site [active] 251221010570 cyanophycin synthetase; Provisional; Region: PRK14016 251221010571 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087 251221010572 Mur ligase middle domain; Region: Mur_ligase_M; cl15713 251221010573 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 251221010574 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 251221010575 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 251221010576 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 251221010577 biotin synthase; Region: bioB; TIGR00433 251221010578 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 251221010579 FeS/SAM binding site; other site 251221010580 Biotin and Thiamin Synthesis associated domain; Region: BATS; cl06149 251221010581 Photosynthetic reaction center (RC) complex, subunit H; RC is an integral membrane protein-pigment complex which catalyzes light-induced reduction of ubiquinone to ubiquinol, generating a transmembrane electrochemical gradient of protons used to produce...; Region: PRCH; cl09959 251221010582 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 251221010583 nudix motif; other site 251221010584 Protein of unknown function (DUF423); Region: DUF423; cl01008 251221010585 TIGR03442 family protein; Region: TIGR03442 251221010586 Glutamine amidotransferases class-II (Gn-AT)_YafJ-type. YafJ is a glutamine amidotransferase-like protein of unknown function found in prokaryotes, eukaryotes and archaea. YafJ has a conserved structural fold similar to those of other class II...; Region: YafJ; cd01908 251221010587 putative active site [active] 251221010588 putative dimer interface [polypeptide binding]; other site 251221010589 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 251221010590 Helix-turn-helix domains; Region: HTH; cl00088 251221010591 Integrase core domain; Region: rve; cl01316 251221010592 Protein of unknwon function (DUF2893); Region: DUF2893; pfam11459 251221010593 Nucleotidyl transferase of unknown function (DUF1814); Region: DUF1814; cl00973 251221010594 SelR domain; Region: SelR; cl00369 251221010595 SOUL heme-binding protein; Region: SOUL; pfam04832 251221010596 SpoVT / AbrB like domain; Region: SpoVT_AbrB; cl00877 251221010597 PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881 251221010598 oligomeric interface; other site 251221010599 putative active site [active] 251221010600 homodimer interface [polypeptide binding]; other site 251221010601 OpgC protein; Region: OpgC_C; cl00792 251221010602 Acyltransferase family; Region: Acyl_transf_3; pfam01757 251221010603 GSH-dependent disulfide bond oxidoreductase; Provisional; Region: PRK13972 251221010604 GST_N family, Ure2p-like subfamily; composed of the Saccharomyces cerevisiae Ure2p and related GSTs. Ure2p is a regulator for nitrogen catabolism in yeast. It represses the expression of several gene products involved in the use of poor nitrogen sources...; Region: GST_N_Ure2p_like; cd03048 251221010605 C-terminal domain interface [polypeptide binding]; other site 251221010606 GSH binding site (G-site) [chemical binding]; other site 251221010607 dimer interface [polypeptide binding]; other site 251221010608 C-terminal, alpha helical domain of Ure2p and related Glutathione S-transferase-like proteins; Region: GST_C_Ure2p_like; cd03178 251221010609 dimer interface [polypeptide binding]; other site 251221010610 N-terminal domain interface [polypeptide binding]; other site 251221010611 gluconate 5-dehydrogenase; Provisional; Region: PRK08213 251221010612 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 251221010613 NAD(P) binding site [chemical binding]; other site 251221010614 active site 251221010615 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 251221010616 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 251221010617 Helix-turn-helix domains; Region: HTH; cl00088 251221010618 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 251221010619 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 251221010620 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 251221010621 structural tetrad; other site 251221010622 FOG: WD40 repeat [General function prediction only]; Region: COG2319 251221010623 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 251221010624 structural tetrad; other site 251221010625 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 251221010626 Uncharacterized conserved protein [Function unknown]; Region: COG5464 251221010627 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 251221010628 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 251221010629 NAD(P) binding site [chemical binding]; other site 251221010630 active site 251221010631 Helix-turn-helix domains; Region: HTH; cl00088 251221010632 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 251221010633 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 251221010634 structural tetrad; other site 251221010635 FOG: WD40 repeat [General function prediction only]; Region: COG2319 251221010636 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 251221010637 structural tetrad; other site 251221010638 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 251221010639 RNA polymerase sigma factor; Provisional; Region: PRK12519 251221010640 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 251221010641 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 251221010642 DNA binding residues [nucleotide binding] 251221010643 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cd00384 251221010644 dimer interface [polypeptide binding]; other site 251221010645 active site 251221010646 Schiff base residues; other site 251221010647 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 251221010648 RNA polymerase sigma factor, cyanobacterial RpoD-like family; Region: Sig70-cyanoRpoD; TIGR02997 251221010649 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 251221010650 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 251221010651 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 251221010652 DNA binding residues [nucleotide binding] 251221010653 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 251221010654 non-specific DNA binding site [nucleotide binding]; other site 251221010655 salt bridge; other site 251221010656 sequence-specific DNA binding site [nucleotide binding]; other site 251221010657 Precorrin-6B methylase 2 [Coenzyme metabolism]; Region: CobL; COG2242 251221010658 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 251221010659 S-adenosylmethionine binding site [chemical binding]; other site 251221010660 Predicted SAM-dependent methyltransferases [General function prediction only]; Region: COG1092 251221010661 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl12011 251221010662 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 251221010663 MoaE interaction surface [polypeptide binding]; other site 251221010664 MoeB interaction surface [polypeptide binding]; other site 251221010665 thiocarboxylated glycine; other site 251221010666 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cl00399 251221010667 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 251221010668 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 251221010669 dimer interface [polypeptide binding]; other site 251221010670 glycine-pyridoxal phosphate binding site [chemical binding]; other site 251221010671 active site 251221010672 folate binding site [chemical binding]; other site 251221010673 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy; cl15773 251221010674 Methylase of polypeptide chain release factors [Translation, ribosomal structure and biogenesis]; Region: HemK; COG2890 251221010675 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 251221010676 S-adenosylmethionine binding site [chemical binding]; other site 251221010677 GSH-dependent disulfide bond oxidoreductase; Provisional; Region: PRK13972 251221010678 GST_N family, Ure2p-like subfamily; composed of the Saccharomyces cerevisiae Ure2p and related GSTs. Ure2p is a regulator for nitrogen catabolism in yeast. It represses the expression of several gene products involved in the use of poor nitrogen sources...; Region: GST_N_Ure2p_like; cd03048 251221010679 C-terminal domain interface [polypeptide binding]; other site 251221010680 GSH binding site (G-site) [chemical binding]; other site 251221010681 dimer interface [polypeptide binding]; other site 251221010682 C-terminal, alpha helical domain of Escherichia coli YfcG Glutathione S-transferases and related uncharacterized proteins; Region: GST_C_YfcG_like; cd10291 251221010683 N-terminal domain interface [polypeptide binding]; other site 251221010684 putative dimer interface [polypeptide binding]; other site 251221010685 active site 251221010686 Manganese catalase, ferritin-like diiron-binding domain; Region: Mn_catalase; cd01051 251221010687 Uncharacterized conserved protein [Function unknown]; Region: COG1633 251221010688 dimanganese center [ion binding]; other site 251221010689 GTPase CgtA; Reviewed; Region: obgE; PRK12299 251221010690 GTP1/OBG; Region: GTP1_OBG; pfam01018 251221010691 Obg subfamily. The Obg nucleotide binding protein subfamily has been implicated in stress response, chromosome partitioning, replication initiation, mycelium development, and sporulation. Obg proteins are among a large group of GTP binding proteins...; Region: Obg; cd01898 251221010692 G1 box; other site 251221010693 GTP/Mg2+ binding site [chemical binding]; other site 251221010694 Switch I region; other site 251221010695 G2 box; other site 251221010696 G3 box; other site 251221010697 Switch II region; other site 251221010698 G4 box; other site 251221010699 G5 box; other site 251221010700 geranylgeranyl diphosphate reductase; Provisional; Region: PLN00093 251221010701 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 251221010702 Glycerophosphodiester phosphodiesterase domain of putative Silicibacter pomeroyi glycerophosphodiester phosphodiesterase and similar proteins; Region: GDPD_SpGDE_like; cd08567 251221010703 Glycerophosphoryl diester phosphodiesterase family; Region: GDPD; pfam03009 251221010704 active site 251221010705 catalytic site [active] 251221010706 metal binding site [ion binding]; metal-binding site 251221010707 Protein of unknown function (DUF760); Region: DUF760; pfam05542 251221010708 RNA methyltransferase, RsmE family; Region: TIGR00046 251221010709 RNA methyltransferase; Region: Methyltrans_RNA; cl00611 251221010710 Iron-sulphur cluster biosynthesis; Region: Fe-S_biosyn; cl00400 251221010711 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cl00528 251221010712 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cl00528 251221010713 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 251221010714 cysteine desulfurase DndA; Region: DNA_S_dndA; TIGR03235 251221010715 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 251221010716 catalytic residue [active] 251221010717 Heat induced stress protein YflT; Region: YflT; pfam11181 251221010718 Tfp pilus assembly protein PilW [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilW; COG4966 251221010719 Possibl zinc metallo-peptidase; Region: DUF1025; cl01577 251221010720 Protein of unknown function (DUF4079); Region: DUF4079; pfam13301 251221010721 Protein of unknown function (DUF2949); Region: DUF2949; pfam11165 251221010722 Prolipoprotein diacylglyceryl transferase; Region: LGT; cl00478 251221010723 Hypothetical chloroplast protein Ycf34; Region: Ycf34; pfam10718 251221010724 Domain of unknown function (DUF477); Region: DUF477; cl01535 251221010725 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 251221010726 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 251221010727 RNA binding surface [nucleotide binding]; other site 251221010728 Pseudouridine synthases are responsible for the synthesis of pseudouridine from uracil in ribosomal RNA. The RsuA subfamily includes Pseudouridine Synthase similar to Ribosomal small subunit pseudouridine 516 synthase. Most of the proteins in this...; Region: PseudoU_synth_RsuA_like; cd02870 251221010729 active site 251221010730 Helix-turn-helix domains; Region: HTH; cl00088 251221010731 rod shape-determining protein MreB; Provisional; Region: PRK13927 251221010732 rod shape-determining protein MreC; Region: MreC; pfam04085 251221010733 DNA polymerase III subunits gamma and tau; Provisional; Region: PRK14954 251221010734 rod shape-determining protein MreD; Region: MreD; cl01087 251221010735 Mg-protoporphyrin IX methyl transferase; Validated; Region: PRK07580 251221010736 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 251221010737 S-adenosylmethionine binding site [chemical binding]; other site 251221010738 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl12011 251221010739 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 251221010740 putative active site [active] 251221010741 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 251221010742 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 251221010743 active site 251221010744 phosphorylation site [posttranslational modification] 251221010745 intermolecular recognition site; other site 251221010746 dimerization interface [polypeptide binding]; other site 251221010747 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 251221010748 DNA binding residues [nucleotide binding] 251221010749 dimerization interface [polypeptide binding]; other site 251221010750 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; cl15275 251221010751 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 251221010752 AAA-like domain; Region: AAA_10; pfam12846 251221010753 Protein of unknown function (DUF1470); Region: DUF1470; pfam07336 251221010754 CGNR zinc finger; Region: zf-CGNR; pfam11706 251221010755 Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980 251221010756 dimer interface [polypeptide binding]; other site 251221010757 [2Fe-2S] cluster binding site [ion binding]; other site 251221010758 Integral membrane protein TerC family; Region: TerC; cl10468 251221010759 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 251221010760 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 251221010761 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 251221010762 Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain); Region: PAC; smart00086 251221010763 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 251221010764 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 251221010765 putative active site [active] 251221010766 heme pocket [chemical binding]; other site 251221010767 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 251221010768 dimer interface [polypeptide binding]; other site 251221010769 phosphorylation site [posttranslational modification] 251221010770 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 251221010771 ATP binding site [chemical binding]; other site 251221010772 Mg2+ binding site [ion binding]; other site 251221010773 G-X-G motif; other site 251221010774 Response regulator receiver domain; Region: Response_reg; pfam00072 251221010775 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 251221010776 active site 251221010777 phosphorylation site [posttranslational modification] 251221010778 intermolecular recognition site; other site 251221010779 dimerization interface [polypeptide binding]; other site 251221010780 Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661 251221010781 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: APH_ChoK_like; cl15691 251221010782 Fungalysin/Thermolysin Propeptide Motif; Region: FTP; pfam07504 251221010783 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 251221010784 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 251221010785 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 251221010786 active site 251221010787 HIGH motif; other site 251221010788 dimer interface [polypeptide binding]; other site 251221010789 KMSKS motif; other site 251221010790 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cl09940 251221010791 Protein of function (DUF2518); Region: DUF2518; pfam10726 251221010792 BolA-like protein; Region: BolA; cl00386 251221010793 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 251221010794 23S rRNA interface [nucleotide binding]; other site 251221010795 L3 interface [polypeptide binding]; other site 251221010796 Ribosomal protein S9/S16; Region: Ribosomal_S9; cl00334 251221010797 Ribosomal protein L31; Region: Ribosomal_L31; cl00377 251221010798 peptide chain release factor 1; Validated; Region: prfA; PRK00591 251221010799 RF-1 domain; Region: RF-1; cl02875 251221010800 RF-1 domain; Region: RF-1; cl02875 251221010801 GTPase Era; Reviewed; Region: era; PRK00089 251221010802 Era subfamily. Era (E. coli Ras-like protein) is a multifunctional GTPase found in all bacteria except some eubacteria. It binds to the 16S ribosomal RNA (rRNA) of the 30S subunit and appears to play a role in the assembly of the 30S subunit, possibly...; Region: Era; cd04163 251221010803 G1 box; other site 251221010804 GTP/Mg2+ binding site [chemical binding]; other site 251221010805 Switch I region; other site 251221010806 G2 box; other site 251221010807 Switch II region; other site 251221010808 G3 box; other site 251221010809 G4 box; other site 251221010810 G5 box; other site 251221010811 K homology RNA-binding domain, type I. KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains that...; Region: KH-I; cl00098 251221010812 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 251221010813 PA_M28_1_1: Protease-associated (PA) domain, peptidase family M28, subfamily-1, subgroup 1. A subgroup of PA-domain containing proteins belonging to the peptidase family M28. Family M28 contains aminopeptidases and carboxypeptidases, and has co-catalytic...; Region: PA_M28_1_1; cd04820 251221010814 Predicted aminopeptidases [General function prediction only]; Region: Iap; COG2234 251221010815 PA/protease or protease-like domain interface [polypeptide binding]; other site 251221010816 M28 Zn-Peptidases containing a PA domain insert; Region: M28_like_PA_2; cd05661 251221010817 metal binding site [ion binding]; metal-binding site 251221010818 phosphoribulokinase; Provisional; Region: PRK07429 251221010819 Phosphoribulokinase (PRK) is an enzyme involved in the Benson-Calvin cycle in chloroplasts or photosynthetic prokaryotes. This enzyme catalyzes the phosphorylation of D-ribulose 5-phosphate to form D-ribulose 1, 5-biphosphate, using ATP and NADPH...; Region: PRK; cd02026 251221010820 active site 251221010821 class III alcohol dehydrogenases; Region: alcohol_DH_class_III; cd08300 251221010822 S-(hydroxymethyl)glutathione dehydrogenase/class III alcohol dehydrogenase; Region: adh_III_F_hyde; TIGR02818 251221010823 substrate binding site [chemical binding]; other site 251221010824 catalytic Zn binding site [ion binding]; other site 251221010825 NAD binding site [chemical binding]; other site 251221010826 structural Zn binding site [ion binding]; other site 251221010827 dimer interface [polypeptide binding]; other site 251221010828 Predicted esterase [General function prediction only]; Region: COG0627 251221010829 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 251221010830 Transcriptional regulator [Transcription]; Region: LysR; COG0583 251221010831 Helix-turn-helix domains; Region: HTH; cl00088 251221010832 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 251221010833 dimerization interface [polypeptide binding]; other site 251221010834 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657 251221010835 dinuclear metal binding motif [ion binding]; other site 251221010836 Tat (twin-arginine translocation) pathway signal sequence; Region: TAT_signal_seq; TIGR01409 251221010837 Predicted phosphatase [General function prediction only]; Region: PhoX; COG3211