-- dump date   	20111121_012429
-- class       	Genbank::misc_feature
-- table       	misc_feature_note
-- id	note
374930000001	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16...; Region: OM_channels; cl00284
374930000002	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
374930000003	ligand-binding site [chemical binding]; other site
374930000004	potential frameshift: common BLAST hit: gi|68249200|ref|YP_248312.1| peptidase E [Haemophilus influenzae 86-028NP]
374930000005	potential frameshift: common BLAST hit: gi|68249201|ref|YP_248313.1| predicted C4-dicarboxylate transporter [Haemophilus influenzae]
374930000006	Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473
374930000007	M20 Peptidases Aminoacyclase-1 indole-3-acetic-L-aspartic acid hydrolase from bacteria and archaea; Region: M20_Acy1_IAAspH_bact; cd05665
374930000008	putative metal binding site [ion binding]; other site
374930000009	dimer interface [polypeptide binding]; other site
374930000010	bifunctional 2',3'-cyclic nucleotide 2'-phosphodiesterase/3'-nucleotidase periplasmic precursor protein; Reviewed; Region: cpdB; PRK09420
374930000011	Escherichia coli CpdB and related proteins, N-terminal metallophosphatase domain; Region: MPP_CpdB_N; cd07410
374930000012	active site
374930000013	metal binding site [ion binding]; metal-binding site
374930000014	5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872
374930000015	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011
374930000016	NAD(FAD)-utilizing enzyme possibly involved in translation [Translation, ribosomal structure and biogenesis]; Region: Gid; cl11520
374930000017	glucose-inhibited division protein A; Region: gidA; TIGR00136
374930000018	S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368
374930000019	S17 interaction site [polypeptide binding]; other site
374930000020	S8 interaction site; other site
374930000021	16S rRNA interaction site [nucleotide binding]; other site
374930000022	streptomycin interaction site [chemical binding]; other site
374930000023	23S rRNA interaction site [nucleotide binding]; other site
374930000024	aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site
374930000025	Ribosomal protein S7p/S5e; Region: Ribosomal_S7; cl00313
374930000026	elongation factor G; Reviewed; Region: PRK00007
374930000027	Elongation factor G (EF-G) subfamily. Translocation is mediated by EF-G (also called translocase).  The structure of EF-G closely resembles that of the complex between EF-Tu and tRNA.  This is an example of molecular mimicry; a protein domain evolved...; Region: EF-G; cd01886
374930000028	G1 box; other site
374930000029	putative GEF interaction site [polypeptide binding]; other site
374930000030	GTP/Mg2+ binding site [chemical binding]; other site
374930000031	Switch I region; other site
374930000032	G2 box; other site
374930000033	G3 box; other site
374930000034	Switch II region; other site
374930000035	G4 box; other site
374930000036	G5 box; other site
374930000037	EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide...; Region: EFG_mtEFG_II; cd04088
374930000038	EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor...; Region: EFG_mtEFG1_IV; cd01434
374930000039	EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G.  Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor...; Region: EFG_mtEFG_C; cd03713
374930000040	elongation factor Tu; Reviewed; Region: PRK00049
374930000041	EF-Tu subfamily.  This subfamily includes orthologs of translation elongation factor EF-Tu in bacteria, mitochondria, and chloroplasts.  It is one of several GTP-binding translation factors found in the larger family of GTP-binding elongation factors; Region: EF_Tu; cd01884
374930000042	G1 box; other site
374930000043	GEF interaction site [polypeptide binding]; other site
374930000044	GTP/Mg2+ binding site [chemical binding]; other site
374930000045	Switch I region; other site
374930000046	G2 box; other site
374930000047	G3 box; other site
374930000048	Switch II region; other site
374930000049	G4 box; other site
374930000050	G5 box; other site
374930000051	EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697
374930000052	Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts)...; Region: EFTU_III; cd03707
374930000053	Antibiotic Binding Site [chemical binding]; other site
374930000054	DsrH like protein; Region: DsrH; cl00953
374930000055	DsrE/DsrF-like family; Region: DrsE; cl00672
374930000056	DsrE/DsrF-like family; Region: DrsE; cl00672
374930000057	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2964
374930000058	YheO-like PAS domain; Region: PAS_6; pfam08348
374930000059	Domain amino terminal to FKBP-type peptidyl-prolyl isomerase; Region: FKBP_N; pfam01346
374930000060	FKBP-type peptidyl-prolyl cis-trans isomerases 1 [Posttranslational modification, protein turnover, chaperones]; Region: FkpA; COG0545
374930000061	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; cl11587
374930000062	SlyX; Region: SlyX; cl01090
374930000063	Peroxiredoxin (PRX) family, PRX5-like subfamily; members are similar to the human protein, PRX5, a homodimeric TRX peroxidase, widely expressed in tissues and found cellularly in mitochondria, peroxisomes and the cytosol. The cellular location of PRX5...; Region: PRX5_like; cd03013
374930000064	catalytic triad [active]
374930000065	dimer interface [polypeptide binding]; other site
374930000066	Glutaredoxin (GRX) family, PRX5 hybrid subfamily; composed of hybrid proteins containing peroxiredoxin (PRX) and GRX domains, which is found in some pathogenic bacteria and cyanobacteria. PRXs are thiol-specific antioxidant (TSA) proteins that confer a...; Region: GRX_hybridPRX5; cd03029
374930000067	GSH binding site [chemical binding]; other site
374930000068	catalytic residues [active]
374930000069	DNA-binding transcriptional regulator OxyR; Provisional; Region: PRK11151
374930000070	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088
374930000071	The C-terminal substrate-binding domain of the LysR-type transcriptional regulator OxyR, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_OxyR; cd08411
374930000072	dimerization interface [polypeptide binding]; other site
374930000073	DNA-binding transcriptional repressor FabR; Provisional; Region: PRK11202
374930000074	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
374930000075	transcription elongation factor GreB; Reviewed; Region: greB; PRK01885
374930000076	domain; Region: GreA_GreB_N; pfam03449
374930000077	C-term; Region: GreA_GreB; pfam01272
374930000078	Transcriptional accessory protein [Transcription]; Region: Tex; COG2183
374930000079	Tex-like protein N-terminal domain; Region: Tex_N; pfam09371
374930000080	Uncharacterised protein family (UPF0081); Region: UPF0081; cl00525
374930000081	S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin...; Region: S1_Tex; cd05685
374930000082	RNA binding site [nucleotide binding]; other site
374930000083	DNA gyrase subunit B; Provisional; Region: gyrB; PRK14939
374930000084	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075
374930000085	TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are...; Region: TopoII_Trans_DNA_gyrase; cd00822
374930000086	anchoring element; other site
374930000087	dimer interface [polypeptide binding]; other site
374930000088	ATP binding site [chemical binding]; other site
374930000089	TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of...; Region: TOPRIM_TopoIIA_GyrB; cd03366
374930000090	active site
374930000091	putative metal-binding site [ion binding]; other site
374930000092	DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986
374930000093	Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative...; Region: RPE; cd00429
374930000094	ribulose-phosphate 3-epimerase; Region: rpe; TIGR01163
374930000095	substrate binding site [chemical binding]; other site
374930000096	hexamer interface [polypeptide binding]; other site
374930000097	metal binding site [ion binding]; metal-binding site
374930000098	Predicted phosphatases [General function prediction only]; Region: Gph; COG0546
374930000099	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cl11391
374930000100	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cd01427
374930000101	motif II; other site
374930000102	helix-turn-helix, Psq domain; Region: HTH_psq; pfam05225
374930000103	putative transposase OrfB; Reviewed; Region: PHA02517
374930000104	Integrase core domain; Region: rve; cl01316
374930000105	Asparagine synthetase (aspartate-ammonia ligase) (AsnA) catalyses the conversion of L-aspartate to L-asparagine in the presence of ATP and ammonia.  AsnA is a homodimeric enzyme which is structurally similiar to the catalytic core domain of class II...; Region: AsnA; cd00645
374930000106	dimer interface [polypeptide binding]; other site
374930000107	active site
374930000108	DNA-binding transcriptional regulator AsnC; Provisional; Region: PRK11179
374930000109	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088
374930000110	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
374930000111	RNA binding surface [nucleotide binding]; other site
374930000112	OPT oligopeptide transporter protein; Region: OPT; cl14607
374930000113	putative oligopeptide transporter, OPT family; Region: TIGR00733
374930000114	CysQ, a 3'-Phosphoadenosine-5'-phosphosulfate (PAPS) 3'-phosphatase, is a bacterial member of the inositol monophosphatase family. It has been proposed that CysQ helps control intracellular levels of PAPS, which is an intermediate in cysteine...; Region: CysQ; cd01638
374930000115	active site
374930000116	glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722
374930000117	Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479
374930000118	Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781
374930000119	6PGL: 6-Phosphogluconolactonase (6PGL) subfamily; 6PGL catalyzes the second step of the oxidative phase of the pentose phosphate pathway, the hydrolyzation of 6-phosphoglucono-1,5-lactone (delta form) to 6-phosphogluconate. 6PGL is thought to guard...; Region: 6PGL; cd01400
374930000120	putative active site [active]
374930000121	CRISPR/Cas system-associated protein Cas2; Region: Cas2_I_II_III; cl11442
374930000122	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
374930000123	6-phosphogluconate dehydrogenase; Validated; Region: PRK09287
374930000124	6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393
374930000125	Glucose-6-phosphate 1-dehydrogenase (EC 1.1.1.49); Region: G6PD_bact; pfam10786
374930000126	bis(5'-nucleosyl)-tetraphosphatase (symmetrical); Region: apaH; TIGR00668
374930000127	Escherichia coli ApaH and related proteins, metallophosphatase domain; Region: MPP_ApaH; cd07422
374930000128	active site
374930000129	metal binding site [ion binding]; metal-binding site
374930000130	Glycosyltransferase family 25 [lipooligosaccharide (LOS) biosynthesis protein] is a family of glycosyltransferases involved in LOS biosynthesis. The members include the beta(1,4) galactosyltransferases: Lgt2 of Moraxella catarrhalis, LgtB and LgtE of...; Region: Glyco_transf_25; cd06532
374930000131	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011
374930000132	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
374930000133	Glycosyltransferase family 25 [lipooligosaccharide (LOS) biosynthesis protein] is a family of glycosyltransferases involved in LOS biosynthesis. The members include the beta(1,4) galactosyltransferases: Lgt2 of Moraxella catarrhalis, LgtB and LgtE of...; Region: Glyco_transf_25; cd06532
374930000134	S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451
374930000135	rRNA binding site [nucleotide binding]; other site
374930000136	predicted 30S ribosome binding site; other site
374930000137	Ribosomal protein S6; Region: Ribosomal_S6; cl00414
374930000138	SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496
374930000139	dimer interface [polypeptide binding]; other site
374930000140	ssDNA binding site [nucleotide binding]; other site
374930000141	tetramer (dimer of dimers) interface [polypeptide binding]; other site
374930000142	Ribosomal protein S18; Region: Ribosomal_S18; cl00373
374930000143	ribosomal protein L9; Region: L9; TIGR00158
374930000144	Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281
374930000145	Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948
374930000146	chaperonin GroEL; Reviewed; Region: groEL; PRK12849
374930000147	GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344
374930000148	ring oligomerisation interface [polypeptide binding]; other site
374930000149	ATP/Mg binding site [chemical binding]; other site
374930000150	stacking interactions; other site
374930000151	hinge regions; other site
374930000152	Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts...; Region: cpn10; cd00320
374930000153	oligomerisation interface [polypeptide binding]; other site
374930000154	mobile loop; other site
374930000155	roof hairpin; other site
374930000156	Urease gamma-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use...; Region: Urease_gamma; cd00390
374930000157	alpha-gamma subunit interface [polypeptide binding]; other site
374930000158	beta-gamma subunit interface [polypeptide binding]; other site
374930000159	Urease beta-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use...; Region: Urease_beta; cd00407
374930000160	gamma-beta subunit interface [polypeptide binding]; other site
374930000161	alpha-beta subunit interface [polypeptide binding]; other site
374930000162	urease subunit alpha; Reviewed; Region: ureC; PRK13207
374930000163	Urease alpha-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, fungi and plants. Their primary role is to allow the use of...; Region: Urease_alpha; cd00375
374930000164	subunit interactions [polypeptide binding]; other site
374930000165	active site
374930000166	flap region; other site
374930000167	UreE urease accessory protein. UreE is a metallochaperone assisting the insertion of a Ni2+ ion in the active site of urease, an important step in the in vivo assembly of urease, an enzyme that hydrolyses urea into ammonia and carbamic acid. The C-...; Region: UreE; cd00571
374930000168	dimer interface [polypeptide binding]; other site
374930000169	catalytic residues [active]
374930000170	Urease accessory protein UreF [Posttranslational modification, protein turnover, chaperones]; Region: UreF; COG0830
374930000171	UreF; Region: UreF; pfam01730
374930000172	Ras-like GTPase superfamily. The Ras-like superfamily of small GTPases consists of several families with an extremely high degree of structural and functional similarity. The Ras superfamily is divided into at least four families in eukaryotes: the Ras...; Region: Ras_like_GTPase; cl10444
374930000173	UreD urease accessory protein; Region: UreD; cl00530
374930000174	aspartate ammonia-lyase; Provisional; Region: aspA; PRK12273
374930000175	Aspartase; Region: Aspartase; cd01357
374930000176	active sites [active]
374930000177	tetramer interface [polypeptide binding]; other site
374930000178	RNA polymerase sigma factor RpoD; Validated; Region: PRK05658
374930000179	Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979
374930000180	Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140
374930000181	Sigma-70, non-essential region; Region: Sigma70_ner; pfam04546
374930000182	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
374930000183	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
374930000184	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial...; Region: Sigma70_r4; cd06171
374930000185	DNA binding residues [nucleotide binding]
374930000186	DNA primase; Validated; Region: dnaG; PRK05667
374930000187	CHC2 zinc finger; Region: zf-CHC2; cl02597
374930000188	DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275
374930000189	TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364
374930000190	active site
374930000191	metal binding site [ion binding]; metal-binding site
374930000192	interdomain interaction site; other site
374930000193	DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410
374930000194	DNA primase DnaG DnaB-binding; Region: DnaG_DnaB_bind; cl07879
374930000195	Ribosomal protein S21; Region: Ribosomal_S21; cl00529
374930000196	UGMP family protein; Validated; Region: PRK09604
374930000197	Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl14000
374930000198	Thymidine kinase; Region: TK; cl00631
374930000199	Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814
374930000200	Transmembrane amino acid transporter protein; Region: Aa_trans; cl00524
374930000201	ferredoxin; Validated; Region: PRK07118
374930000202	Ribonuclease T2 (RNase T2) is a widespread family of secreted RNases found in every organism examined thus far.  This family includes RNase Rh, RNase MC1, RNase LE, and self-incompatibility RNases (S-RNases).  Plant T2 RNases are expressed during leaf...; Region: RNase_T2_prok; cd01062
374930000203	B1 nucleotide binding pocket [chemical binding]; other site
374930000204	B2 nucleotide binding pocket [chemical binding]; other site
374930000205	CAS motifs; other site
374930000206	Active site [active]
374930000207	Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318
374930000208	substrate binding site [chemical binding]; other site
374930000209	hinge regions; other site
374930000210	ADP binding site [chemical binding]; other site
374930000211	catalytic site [active]
374930000212	fructose-bisphosphate aldolase; Provisional; Region: PRK09197
374930000213	Class II Type A, Fructose-1,6-bisphosphate (FBP) aldolases. The enzyme catalyses the zinc-dependent, reversible aldol condensation of dihydroxyacetone phosphate with glyceraldehyde-3-phosphate to form fructose-1,6-bisphosphate. FBP aldolase is...; Region: FBP_aldolase_IIA; cd00946
374930000214	active site
374930000215	intersubunit interface [polypeptide binding]; other site
374930000216	zinc binding site [ion binding]; other site
374930000217	Na+ binding site [ion binding]; other site
374930000218	potential frameshift: common BLAST hit: gi|68249120|ref|YP_248232.1| ADP-heptose--lipooligosaccharide heptosyltransferase III
374930000219	potential frameshift: common BLAST hit: gi|68249119|ref|YP_248231.1| predicted membrane protein [Haemophilus influenzae 86-028NP]
374930000220	glycine radical enzyme, YjjI family; Region: glycyl_YjjI; TIGR04040
374930000221	Glycine radical; Region: Gly_radical; cl12026
374930000222	glycine radical enzyme activase, YjjW family; Region: activase_YjjW; TIGR04041
374930000223	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster...; Region: Radical_SAM; cl14056
374930000224	nucleoside transporter; Region: nupC; TIGR00804
374930000225	Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773
374930000226	Nucleoside recognition; Region: Gate; cl00486
374930000227	Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662
374930000228	Phosphorylase superfamily; Region: PNP_UDP_1; cl00303
374930000229	Uridine phosphorylase [Nucleotide transport and metabolism]; Region: Udp; COG2820
374930000230	50S ribosomal protein L11; Validated; Region: rplK; PRK00140
374930000231	Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349
374930000232	23S rRNA interface [nucleotide binding]; other site
374930000233	L7/L12 interface [polypeptide binding]; other site
374930000234	putative thiostrepton binding site; other site
374930000235	L25 interface [polypeptide binding]; other site
374930000236	Ribosomal protein L1.  The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA.  In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that...; Region: Ribosomal_L1; cd00403
374930000237	mRNA/rRNA interface [nucleotide binding]; other site
374930000238	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl04593
374930000239	DNA-directed RNA polymerase subunit beta'; Provisional; Region: PRK00566
374930000240	RNA polymerase beta subunit; Region: RNA_pol_Rpb2_1; cl04591
374930000241	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653
374930000242	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl04593
374930000243	RPB11 interaction site [polypeptide binding]; other site
374930000244	RPB12 interaction site [polypeptide binding]; other site
374930000245	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653
374930000246	RPB1 interaction site [polypeptide binding]; other site
374930000247	RPB11 interaction site [polypeptide binding]; other site
374930000248	RPB10 interaction site [polypeptide binding]; other site
374930000249	RPB3 interaction site [polypeptide binding]; other site
374930000250	DNA-directed RNA polymerase, beta' subunit/160 kD subunit [Transcription]; Region: RpoC; COG0086
374930000251	RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997
374930000252	RNA polymerase Rpb1, domain 2; Region: RNA_pol_Rpb1_2; cl11591
374930000253	RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983
374930000254	RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000
374930000255	Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429
374930000256	Rpb1 - Rpb6 interaction site [polypeptide binding]; other site
374930000257	bifunctional DNA-directed RNA polymerase subunit beta/beta'; Reviewed; Region: PRK09603
374930000258	Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429
374930000259	Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655
374930000260	DNA binding site [nucleotide binding]
374930000261	Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site
374930000262	Tellurite-resistance/Dicarboxylate Transporter (TDT) family includes TehA protein; Region: TDT_TehA; cd09324
374930000263	gating phenylalanine in ion channel; other site
374930000264	Escherichia coli YaeB and related proteins; Region: UPF0066; cd09281
374930000265	homodimer interaction site [polypeptide binding]; other site
374930000266	cofactor binding site; other site
374930000267	1,4-dihydroxy-2-naphthoate octaprenyltransferase [Coenzyme metabolism]; Region: MenA; COG1575
374930000268	UbiA prenyltransferase family; Region: UbiA; cl00337
374930000269	Demethylmenaquinone methyltransferase; Region: Methyltransf_6; cl00480
374930000270	Uncharacterized protein family, UPF0114; Region: UPF0114; cl01078
374930000271	transcriptional repressor RbsR; Provisional; Region: PRK10423
374930000272	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
374930000273	DNA binding site [nucleotide binding]
374930000274	domain linker motif; other site
374930000275	Ligand-binding domain of purine repressor, PurR, which functions as the master regulatory protein of de novo purine nucleotide biosynthesis in Escherichia coli; Region: PBP1_PurR; cd06275
374930000276	dimerization interface [polypeptide binding]; other site
374930000277	ligand binding site [chemical binding]; other site
374930000278	Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105
374930000279	Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of...; Region: ribokinase; cd01174
374930000280	substrate binding site [chemical binding]; other site
374930000281	dimer interface [polypeptide binding]; other site
374930000282	ATP binding site [chemical binding]; other site
374930000283	D-ribose transporter subunit RbsB; Provisional; Region: PRK10653
374930000284	Periplasmic sugar-binding domain of the thermophilic Thermoanaerobacter tengcongensis ribose binding protein (ttRBP) and its mesophilic homologs; Region: PBP1_ribose_binding; cd06323
374930000285	ligand binding site [chemical binding]; other site
374930000286	dimerization interface [polypeptide binding]; other site
374930000287	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
374930000288	TM-ABC transporter signature motif; other site
374930000289	D-ribose transporter ATP binding protein; Provisional; Region: PRK10762
374930000290	This family represents the domain I of the carbohydrate uptake proteins that transport only monosaccharides (Monos).  The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and...; Region: ABC_Carb_Monos_I; cd03216
374930000291	Walker A/P-loop; other site
374930000292	ATP binding site [chemical binding]; other site
374930000293	Q-loop/lid; other site
374930000294	ABC transporter signature motif; other site
374930000295	Walker B; other site
374930000296	D-loop; other site
374930000297	H-loop/switch region; other site
374930000298	This family represents domain II of the carbohydrate uptake proteins that transport only monosaccharides (Monos).  The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and hexoses (; Region: ABC_Carb_Monos_II; cd03215
374930000299	RbsD / FucU transport protein family; Region: RbsD_FucU; cl00809
374930000300	RmuC family; Region: RmuC; pfam02646
374930000301	Malate:quinone oxidoreductase (Mqo); Region: Mqo; cl14881
374930000302	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644
374930000303	Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687
374930000304	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
374930000305	ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201
374930000306	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009
374930000307	Walker A motif; other site
374930000308	ATP binding site [chemical binding]; other site
374930000309	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099
374930000310	Protease HslV and the ATPase/chaperone HslU are part of an ATP-dependent proteolytic system that is the prokaryotic homolog of the proteasome. HslV is a dimer of hexamers (a dodecamer) that forms a central proteolytic chamber with active sites on the...; Region: protease_HslV; cd01913
374930000311	HslU subunit interaction site [polypeptide binding]; other site
374930000312	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cl11391
374930000313	Integrase core domain; Region: rve; cl01316
374930000314	S-Ribosylhomocysteinase (LuxS); Region: LuxS; cl00802
374930000315	SNARE associated Golgi protein; Region: SNARE_assoc; cl00429
374930000316	beta-phosphoglucomutase family hydrolase; Region: PGMB-YQAB-SF; TIGR02009
374930000317	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cl11391
374930000318	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cd01427
374930000319	motif II; other site
374930000320	16S rRNA methyltransferase GidB; Reviewed; Region: gidB; PRK00107
374930000321	ATP synthase I chain; Region: ATP_synt_I; cl09170
374930000322	ATP synthase A chain; Region: ATP-synt_A; cl00413
374930000323	ATP synthase subunit C; Region: ATP-synt_C; cl00466
374930000324	ATP synthase B/B' CF(0); Region: ATP-synt_B; cl07975
374930000325	F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711
374930000326	ATP synthase B/B' CF(0); Region: ATP-synt_B; cl07975
374930000327	ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213
374930000328	F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281
374930000329	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
374930000330	F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132
374930000331	beta subunit interaction interface [polypeptide binding]; other site
374930000332	Walker A motif; other site
374930000333	ATP binding site [chemical binding]; other site
374930000334	Walker B motif; other site
374930000335	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
374930000336	ATP synthase; Region: ATP-synt; cl00365
374930000337	F0F1 ATP synthase subunit beta; Validated; Region: PRK09280
374930000338	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
374930000339	F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133
374930000340	alpha subunit interaction interface [polypeptide binding]; other site
374930000341	Walker A motif; other site
374930000342	ATP binding site [chemical binding]; other site
374930000343	Walker B motif; other site
374930000344	inhibitor binding site; inhibition site
374930000345	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
374930000346	F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571
374930000347	ATP synthase, Delta/Epsilon chain, beta-sandwich domain; Region: ATP-synt_DE_N; cl10033
374930000348	Transmembrane amino acid transporter protein; Region: Aa_trans; cl00524
374930000349	potential frameshift: common BLAST hit: gi|68249077|ref|YP_248189.1| histidine biosynthesis bifunctional protein HisIE [Haemophilus]
374930000350	Imidazoleglycerol-phosphate synthase [Amino acid transport and metabolism]; Region: HisF; COG0107
374930000351	The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)-formimino-5-; Region: HisF; cd04731
374930000352	substrate binding site [chemical binding]; other site
374930000353	glutamase interaction surface [polypeptide binding]; other site
374930000354	Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase [Amino acid transport and metabolism]; Region: HisA; COG0106
374930000355	HisA.  Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1'-...; Region: HisA; cd04732
374930000356	catalytic residues [active]
374930000357	imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13170
374930000358	Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748
374930000359	putative active site [active]
374930000360	oxyanion strand; other site
374930000361	catalytic triad [active]
374930000362	imidazole glycerol-phosphate dehydratase/histidinol phosphatase; Provisional; Region: PRK05446
374930000363	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cd01427
374930000364	active site
374930000365	motif I; other site
374930000366	motif II; other site
374930000367	Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914
374930000368	putative active site pocket [active]
374930000369	4-fold oligomerization interface [polypeptide binding]; other site
374930000370	metal binding residues [ion binding]; metal-binding site
374930000371	3-fold/trimer interface [polypeptide binding]; other site
374930000372	histidinol-phosphate aminotransferase; Region: hisC; TIGR01141
374930000373	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
374930000374	pyridoxal 5'-phosphate binding site [chemical binding]; other site
374930000375	homodimer interface [polypeptide binding]; other site
374930000376	catalytic residue [active]
374930000377	Histidinol dehydrogenase [Amino acid transport and metabolism]; Region: HisD; COG0141
374930000378	E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent oxidation of L-histidinol to L-...; Region: Histidinol_dh; cd06572
374930000379	NAD binding site [chemical binding]; other site
374930000380	dimerization interface [polypeptide binding]; other site
374930000381	product binding site; other site
374930000382	substrate binding site [chemical binding]; other site
374930000383	zinc binding site [ion binding]; other site
374930000384	catalytic residues [active]
374930000385	ATP phosphoribosyltransferase; Reviewed; Region: hisG; PRK00489
374930000386	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
374930000387	HisG, C-terminal domain; Region: HisG_C; cl06867
374930000388	hypothetical protein; Provisional; Region: PRK11820
374930000389	YicC-like family, N-terminal region; Region: YicC_N; pfam03755
374930000390	Domain of unknown function (DUF1732); Region: DUF1732; pfam08340
374930000391	Predicted aminomethyltransferase related to GcvT [General function prediction only]; Region: COG0354
374930000392	folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317
374930000393	Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669
374930000394	D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK11790
374930000395	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
374930000396	C-terminal ACT (regulatory) domain of D-3-Phosphoglycerate Dehydrogenase (3PGDH) found in fungi and bacteria; Region: ACT_3PGDH; cd04901
374930000397	L-serine binding site [chemical binding]; other site
374930000398	ACT domain interface; other site
374930000399	RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398
374930000400	tetramer (dimer of dimers) interface [polypeptide binding]; other site
374930000401	active site
374930000402	dimer interface [polypeptide binding]; other site
374930000403	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster...; Region: Radical_SAM; cl14056
374930000404	HemN C-terminal region; Region: HemN_C; pfam06969
374930000405	Found in ATP-dependent protease La (LON); Region: LON; cl01056
374930000406	DNA-binding ATP-dependent protease La; Provisional; Region: PRK10787
374930000407	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009
374930000408	Walker A motif; other site
374930000409	ATP binding site [chemical binding]; other site
374930000410	Walker B motif; other site
374930000411	arginine finger; other site
374930000412	Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362
374930000413	Protein of unknown function (DUF535); Region: DUF535; cl01128
374930000414	MazG family protein; Region: mazG; TIGR00444
374930000415	MazG nucleotide pyrophosphohydrolase domain; Region: MazG; cl00345
374930000416	MazG nucleotide pyrophosphohydrolase domain; Region: MazG; cl00345
374930000417	Phosphoribosyl transferase domain; Region: Pribosyltran; cl00309
374930000418	Parvulin-like peptidyl-prolyl isomerase [Posttranslational modification, protein turnover, chaperones]; Region: SurA; COG0760
374930000419	SurA N-terminal domain; Region: SurA_N; pfam09312
374930000420	PPIC-type PPIASE domain; Region: Rotamase; cl08278
374930000421	YceG-like family; Region: YceG; pfam02618
374930000422	proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010
374930000423	dimerization interface [polypeptide binding]; other site
374930000424	thymidylate kinase; Validated; Region: tmk; PRK00698
374930000425	Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting...; Region: TMPK; cd01672
374930000426	TMP-binding site; other site
374930000427	ATP-binding site [chemical binding]; other site
374930000428	DNA polymerase III subunit delta'; Validated; Region: PRK06871
374930000429	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099
374930000430	C terminal; Region: DNApol3-delta_C; pfam09115
374930000431	TatD like proteins;  E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310
374930000432	putative deoxyribonuclease YjjV; Provisional; Region: PRK11449
374930000433	active site
374930000434	Protein of unknown function (DUF1523); Region: DUF1523; pfam07509
374930000435	Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253
374930000436	Domain of unknown function DUF21; Region: DUF21; pfam01595
374930000437	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
374930000438	Transporter associated domain; Region: CorC_HlyC; pfam03471
374930000439	CRISPR/Cas system-associated protein Cas2; Region: Cas2_I_II_III; cl11442
374930000440	bifunctional PTS system fructose-specific transporter subunit IIA/HPr protein; Provisional; Region: PRK13779
374930000441	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
374930000442	active site
374930000443	phosphorylation site [posttranslational modification]
374930000444	Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367
374930000445	dimerization domain swap beta strand [polypeptide binding]; other site
374930000446	regulatory protein interface [polypeptide binding]; other site
374930000447	active site
374930000448	regulatory phosphorylation site [posttranslational modification]; other site
374930000449	Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367
374930000450	dimerization domain swap beta strand [polypeptide binding]; other site
374930000451	regulatory protein interface [polypeptide binding]; other site
374930000452	active site
374930000453	regulatory phosphorylation site [posttranslational modification]; other site
374930000454	Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105
374930000455	1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164
374930000456	putative substrate binding site [chemical binding]; other site
374930000457	putative ATP binding site [chemical binding]; other site
374930000458	PTS system fructose-specific transporter subunits IIBC; Provisional; Region: PRK10712
374930000459	N-terminal domain of the phosphotransferase system fructose-specific component IIB [Carbohydrate transport and metabolism]; Region: COG3925
374930000460	PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA...; Region: PTS_IIB_fructose; cd05569
374930000461	P-loop; other site
374930000462	active site
374930000463	phosphorylation site [posttranslational modification]
374930000464	Phosphotransferase system, EIIC; Region: PTS_EIIC; cl00557
374930000465	Preprotein translocase SecG subunit; Region: SecG; cl09123
374930000466	DNA topoisomerase III, bacteria and conjugative plasmid; Region: topB; TIGR01056
374930000467	TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by:...; Region: TOPRIM_TopoIA_TopoIII; cd03362
374930000468	active site
374930000469	putative interdomain interaction site [polypeptide binding]; other site
374930000470	putative metal-binding site [ion binding]; other site
374930000471	putative nucleotide binding site [chemical binding]; other site
374930000472	DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded...; Region: TOP1Ac; cd00186
374930000473	domain I; other site
374930000474	DNA binding groove [nucleotide binding]
374930000475	phosphate binding site [ion binding]; other site
374930000476	domain II; other site
374930000477	domain III; other site
374930000478	nucleotide binding site [chemical binding]; other site
374930000479	catalytic site [active]
374930000480	domain IV; other site
374930000481	recombination protein RecR; Reviewed; Region: recR; PRK00076
374930000482	RecR protein; Region: RecR; pfam02132
374930000483	TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR.  RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025
374930000484	putative active site [active]
374930000485	putative metal-binding site [ion binding]; other site
374930000486	tetramer interface [polypeptide binding]; other site
374930000487	Uncharacterised BCR, YbaB family COG0718; Region: DUF149; cl00494
374930000488	Protein of unknown function (DUF519); Region: DUF519; cl04492
374930000489	penicillin-binding protein 1a; Provisional; Region: mrcA; PRK11636
374930000490	Transglycosylase; Region: Transgly; cl07896
374930000491	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01039
374930000492	Tfp pilus assembly protein, ATPase PilM [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilM; COG4972
374930000493	Pilus assembly protein, PilP; Region: PilP; cl01235
374930000494	type IV pilus secretin (or competence protein) PilQ; Region: IV_pilus_PilQ; TIGR02515
374930000495	Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958
374930000496	Bacterial type II and III secretion system protein; Region: Secretin; cl02829
374930000497	DNA utilization protein GntX; Provisional; Region: PRK11595
374930000498	Phosphoribosyl transferase domain; Region: Pribosyltran; cl00309
374930000499	Iron-sulphur cluster biosynthesis; Region: Fe-S_biosyn; cl00400
374930000500	Fe/S biogenesis protein NfuA; Provisional; Region: PRK11190
374930000501	NifU-like domain; Region: NifU; cl00484
374930000502	NADH pyrophosphatase; Reviewed; Region: nudC; PRK00241
374930000503	NADH pyrophosphatase-like rudimentary NUDIX domain; Region: NUDIX-like; pfam09296
374930000504	NADH pyrophosphatase zinc ribbon domain; Region: zf-NADH-PPase; pfam09297
374930000505	NADH pyrophosphatase, a member of the Nudix hydrolase superfamily, catalyzes the cleavage of NADH into reduced nicotinamide mononucleotide (NMNH) and AMP. Like other members of the Nudix family, it requires a divalent cation, such as Mg2+ or Mn2+, for...; Region: NADH_pyrophosphatase; cd03429
374930000506	putative NADH binding site [chemical binding]; other site
374930000507	putative active site [active]
374930000508	nudix motif; other site
374930000509	putative metal binding site [ion binding]; other site
374930000510	Protein of unknown function (DUF416); Region: DUF416; cl01166
374930000511	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and higher-...; Region: HU_IHF; cd00591
374930000512	IHF dimer interface [polypeptide binding]; other site
374930000513	IHF - DNA interface [nucleotide binding]; other site
374930000514	glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331
374930000515	Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans).  The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate...; Region: GFAT; cd00714
374930000516	glutaminase active site [active]
374930000517	SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008
374930000518	dimer interface [polypeptide binding]; other site
374930000519	active site
374930000520	SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009
374930000521	dimer interface [polypeptide binding]; other site
374930000522	active site
374930000523	Disulfide bond formation protein DsbB; Region: DsbB; cl00649
374930000524	potential frameshift: common BLAST hit: gi|30995374|ref|NP_438588.2| Na+/H+ antiporter [Haemophilus influenzae Rd KW20]
374930000525	fatty acid metabolism transcriptional regulator FadR; Region: fadR_gamma; TIGR02812
374930000526	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
374930000527	DNA-binding site [nucleotide binding]; DNA binding site
374930000528	FCD domain; Region: FCD; cl11656
374930000529	phosphatidylserine synthase; Provisional; Region: pssA; PRK09428
374930000530	Catalytic domain, repeat 1, of phosphatidylserine synthases from gram-negative bacteria; Region: PLDc_PSS_G_neg_1; cd09134
374930000531	domain interface [polypeptide binding]; other site
374930000532	putative active site [active]
374930000533	catalytic site [active]
374930000534	Catalytic domain, repeat 2, of phosphatidylserine synthases from gram-negative bacteria; Region: PLDc_PSS_G_neg_2; cd09136
374930000535	domain interface [polypeptide binding]; other site
374930000536	putative active site [active]
374930000537	catalytic site [active]
374930000538	rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566
374930000539	RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032
374930000540	SpoU rRNA Methylase family; Region: SpoU_methylase; cl00362
374930000541	Predicted O-methyltransferase [General function prediction only]; Region: COG4123
374930000542	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440
374930000543	S-adenosylmethionine binding site [chemical binding]; other site
374930000544	ATP-dependent RNA helicase SrmB; Provisional; Region: PRK11192
374930000545	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif (...; Region: DEADc; cd00268
374930000546	ATP binding site [chemical binding]; other site
374930000547	Mg++ binding site [ion binding]; other site
374930000548	motif III; other site
374930000549	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
374930000550	nucleotide binding region [chemical binding]; other site
374930000551	ATP-binding site [chemical binding]; other site
374930000552	putative protease; Provisional; Region: PRK15452
374930000553	Peptidase family U32; Region: Peptidase_U32; cl03113
374930000554	metabolite-proton symporter; Region: 2A0106; TIGR00883
374930000555	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
374930000556	putative substrate translocation pore; other site
374930000557	Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5- (beta-...; Region: TMP_TenI; cd00564
374930000558	thiamine phosphate binding site [chemical binding]; other site
374930000559	active site
374930000560	pyrophosphate binding site [ion binding]; other site
374930000561	bifunctional hydroxy-methylpyrimidine kinase/ hydroxy-phosphomethylpyrimidine kinase; Reviewed; Region: PRK06427
374930000562	4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169
374930000563	dimer interface [polypeptide binding]; other site
374930000564	substrate binding site [chemical binding]; other site
374930000565	ATP binding site [chemical binding]; other site
374930000566	4-methyl-5-beta-hydroxyethylthiazole (Thz) kinase catalyzes the phosphorylation of the hydroxylgroup of Thz. A reaction that allows cells to recycle Thz into the thiamine biosynthesis pathway, as an alternative to its synthesis from cysteine, tyrosine...; Region: THZ_kinase; cd01170
374930000567	substrate binding site [chemical binding]; other site
374930000568	multimerization interface [polypeptide binding]; other site
374930000569	ATP binding site [chemical binding]; other site
374930000570	Surface antigen; Region: Surface_Ag_2; cl01155
374930000571	ribonuclease E; Reviewed; Region: rne; PRK10811
374930000572	S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453
374930000573	homodimer interface [polypeptide binding]; other site
374930000574	oligonucleotide binding site [chemical binding]; other site
374930000575	ribonuclease E; Reviewed; Region: rne; PRK10811
374930000576	Polyribonucleotide phosphorylase C terminal; Region: PNPase_C; pfam12111
374930000577	23S rRNA pseudouridylate synthase C; Provisional; Region: PRK11025
374930000578	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cl09940
374930000579	PseudoU_synth_RsuA/RluD: Pseudouridine synthase, RsuA/RluD family. This group is comprised of eukaryotic, bacterial and archeal proteins similar to eight site specific Escherichia coli pseudouridine synthases: RsuA, RluA, RluB, RluC, RluD, RluE, RluF...; Region: PseudoU_synth_RluCD_like; cd02869
374930000580	active site
374930000581	Hfq, an abundant, ubiquitous RNA-binding protein, functions as a pleiotrophic regulator of RNA metabolism in prokaryotes, required for transcription of some transcripts and degradation of others. Hfq binds small RNA molecules called riboregulators that...; Region: Hfq; cd01716
374930000582	Sm1 motif; other site
374930000583	intra - hexamer interaction site; other site
374930000584	inter - hexamer interaction site [polypeptide binding]; other site
374930000585	nucleotide binding pocket [chemical binding]; other site
374930000586	Sm2 motif; other site
374930000587	Transcriptional regulator of aromatic amino acids metabolism [Transcription / Amino acid transport and metabolism]; Region: TyrR; COG3283
374930000588	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009
374930000589	Walker A motif; other site
374930000590	ATP binding site [chemical binding]; other site
374930000591	Walker B motif; other site
374930000592	arginine finger; other site
374930000593	putative peptidase; Provisional; Region: PRK11649
374930000594	Peptidase family M23; Region: Peptidase_M23; pfam01551
374930000595	ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121
374930000596	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099
374930000597	Walker A/P-loop; other site
374930000598	ATP binding site [chemical binding]; other site
374930000599	Q-loop/lid; other site
374930000600	ABC transporter signature motif; other site
374930000601	Walker B; other site
374930000602	D-loop; other site
374930000603	H-loop/switch region; other site
374930000604	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist...; Region: TM_ABC_iron-siderophores_like; cd06550
374930000605	ABC-ATPase subunit  interface; other site
374930000606	dimer interface [polypeptide binding]; other site
374930000607	putative PBP binding regions; other site
374930000608	Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl00513
374930000609	Pyridoxal kinase plays a key role in the synthesis of the active coenzyme pyridoxal-5'-phosphate  (PLP), by catalyzing the phosphorylation of the precursor vitamin B6 in the presence of Zn2+ and ATP. Mammals are unable to synthesize PLP de novo and...; Region: pyridoxal_pyridoxamine_kinase; cd01173
374930000610	dimer interface [polypeptide binding]; other site
374930000611	pyridoxal binding site [chemical binding]; other site
374930000612	ATP binding site [chemical binding]; other site
374930000613	tRNA(Ile)-lysidine synthetase; Provisional; Region: tilS; PRK10660
374930000614	N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992
374930000615	Ligand Binding Site [chemical binding]; other site
374930000616	TilS substrate binding domain; Region: TilS; pfam09179
374930000617	B3/4 domain; Region: B3_4; cl11458
374930000618	MutH is a 28kD endonuclease involved in methyl-directed DNA mismatch repair in gram negative bacteria. MutH is both sequence-specific and methylation-specific, introducing a nick in the unmethylated strand of a hemi-methylated d(GATC) DNA duplex; Region: MutH_Sau3AI; cd00583
374930000619	putative DNA-binding cleft [nucleotide binding]; other site
374930000620	putative DNA clevage site; other site
374930000621	molecular lever; other site
374930000622	6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870
374930000623	methylated-DNA--protein-cysteine methyltransferase; Provisional; Region: PRK00901
374930000624	The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445
374930000625	DNA binding site [nucleotide binding]
374930000626	active site
374930000627	Long-chain fatty acid transport protein [Lipid metabolism]; Region: FadL; COG2067
374930000628	Outer membrane protein transport protein (OMPP1/FadL/TodX); Region: Toluene_X; cl09488
374930000629	Protein of unknown function (DUF406); Region: DUF406; cl11449
374930000630	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
374930000631	Enterobacter aerogenes GpdQ and related proteins, metallophosphatase domain; Region: MPP_GpdQ; cd07402
374930000632	active site
374930000633	metal binding site [ion binding]; metal-binding site
374930000634	hexamer interface [polypeptide binding]; other site
374930000635	nudix-type nucleoside diphosphatase, YffH/AdpP family; Region: TIGR00052
374930000636	ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as...; Region: ADPRase_NUDT5; cd03424
374930000637	dimer interface [polypeptide binding]; other site
374930000638	ADP-ribose binding site [chemical binding]; other site
374930000639	active site
374930000640	nudix motif; other site
374930000641	metal binding site [ion binding]; metal-binding site
374930000642	exodeoxyribonuclease VII, large subunit; Region: xseA; TIGR00237
374930000643	ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a single-strand-...; Region: ExoVII_LU_OBF; cd04489
374930000644	generic binding surface II; other site
374930000645	generic binding surface I; other site
374930000646	Uncharacterized conserved protein [Function unknown]; Region: COG2850
374930000647	Uncharacterised protein family (UPF0125); Region: UPF0125; cl01096
374930000648	Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462
374930000649	putative active site [active]
374930000650	GTP-binding protein YchF; Reviewed; Region: PRK09601
374930000651	YchF subfamily.  YchF is a member of the Obg family, which includes four other subfamilies of GTPases: Obg, DRG, Ygr210, and NOG1.  Obg is an essential gene that is involved in DNA replication in C. crescentus and Streptomyces griseus and is associated...; Region: YchF; cd01900
374930000652	G1 box; other site
374930000653	GTP/Mg2+ binding site [chemical binding]; other site
374930000654	Switch I region; other site
374930000655	G2 box; other site
374930000656	Switch II region; other site
374930000657	G3 box; other site
374930000658	G4 box; other site
374930000659	G5 box; other site
374930000660	TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867
374930000661	potential frameshift: common BLAST hit: gi|59802031|ref|YP_208743.1| putative trans-acylase protein [Neisseria gonorrhoeae FA 1090]
374930000662	ribonuclease D; Provisional; Region: PRK10829
374930000663	DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142
374930000664	putative active site [active]
374930000665	catalytic site [active]
374930000666	putative substrate binding site [chemical binding]; other site
374930000667	HRDC domain; Region: HRDC; cl02578
374930000668	long-chain-fatty-acid--CoA ligase; Validated; Region: PRK08974
374930000669	Acyl-protein synthetase, LuxE; Region: LuxE; cl10450
374930000670	Outer membrane lipoprotein Slp family; Region: Slp; cl01164
374930000671	Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl14000
374930000672	Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199
374930000673	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl14882
374930000674	CRISPR/Cas system-associated DinG family helicase Csf4; Region: Csf4_U; cl09250
374930000675	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active...; Region: 4HBT; cd00586
374930000676	active site
374930000677	MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568
374930000678	Biopolymer transport protein ExbD/TolR; Region: ExbD; cl00537
374930000679	TolA C-terminal; Region: TolA; pfam06519
374930000680	translocation protein TolB; Provisional; Region: tolB; PRK01742
374930000681	TolB amino-terminal domain; Region: TolB_N; pfam04052
374930000682	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues...; Region: WD40; cl02567
374930000683	structural tetrad; other site
374930000684	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
374930000685	ligand binding site [chemical binding]; other site
374930000686	potential frameshift: common BLAST hit: gi|113460425|ref|YP_718487.1| possible tRNA/rRNA methyltransferase [Haemophilus somnus 129PT]
374930000687	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088
374930000688	Rrf2 family protein; Region: rrf2_super; TIGR00738
374930000689	Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520
374930000690	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
374930000691	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
374930000692	catalytic residue [active]
374930000693	Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664
374930000694	trimerization site [polypeptide binding]; other site
374930000695	active site
374930000696	Iron-sulphur cluster biosynthesis; Region: Fe-S_biosyn; cl00400
374930000697	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of...; Region: DnaJ; cl02542
374930000698	Fe-S protein assembly co-chaperone HscB; Region: hscB; TIGR00714
374930000699	HSCB C-terminal oligomerisation domain; Region: HSCB_C; pfam07743
374930000700	Protein of unknown function DUF2625; Region: DUF2625; cl08177
374930000701	chaperone protein HscA; Provisional; Region: hscA; PRK05183
374930000702	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
374930000703	catalytic loop [active]
374930000704	iron binding site [ion binding]; other site
374930000705	Protein of unknown function (DUF528); Region: DUF528; cl01123
374930000706	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2976
374930000707	Uncharacterized protein conserved in bacteria (DUF2133); Region: DUF2133; pfam09976
374930000708	histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037
374930000709	Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: HisRS-like_core; cd00773
374930000710	dimer interface [polypeptide binding]; other site
374930000711	motif 1; other site
374930000712	active site
374930000713	motif 2; other site
374930000714	motif 3; other site
374930000715	HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859
374930000716	anticodon binding site; other site
374930000717	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366
374930000718	1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate synthase; Region: ispG_gcpE; TIGR00612
374930000719	Predicted transcriptional regulator contains Xre-like HTH domain [Function unknown]; Region: COG1426
374930000720	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl09100
374930000721	type IV pilus biogenesis/stability protein PilW; Region: type_IV_pilW; TIGR02521
374930000722	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cl02429
374930000723	binding surface
374930000724	TPR motif; other site
374930000725	ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK11194
374930000726	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster...; Region: Radical_SAM; cd01335
374930000727	FeS/SAM binding site; other site
374930000728	Beta-lactamase; Region: Beta-lactamase; cl01009
374930000729	Metal binding protein PsaA.  These proteins have been shown to function as initial receptors in ABC transport of Mn2+ and as surface adhesins in some eubacterial species.  They belong to the TroA superfamily of periplasmic metal binding proteins that...; Region: PsaA; cd01137
374930000730	Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297
374930000731	metal binding site [ion binding]; metal-binding site
374930000732	manganese/iron transporter ATP-binding protein; Provisional; Region: PRK15056
374930000733	ABC component of the metal-type transporters.  This family includes transporters involved in the uptake of various metallic cations such as iron, manganese, and zinc.  The ATPases of this group of transporters are very similar to members of iron-...; Region: ABC_Metallic_Cations; cd03235
374930000734	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist...; Region: TM_ABC_iron-siderophores_like; cd06550
374930000735	ABC-ATPase subunit  interface; other site
374930000736	dimer interface [polypeptide binding]; other site
374930000737	putative PBP binding regions; other site
374930000738	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist...; Region: TM_ABC_iron-siderophores_like; cd06550
374930000739	ABC-ATPase subunit  interface; other site
374930000740	dimer interface [polypeptide binding]; other site
374930000741	putative PBP binding regions; other site
374930000742	Heme oxygenase catalyzes the rate limiting step in the degradation of heme to bilirubin, it is essential for recycling of iron from heme. Heme is used as a substrate and cofactor for its own degradation to biliverdin, iron, and carbon monoxide. This...; Region: HemeO; cl15243
374930000743	ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715
374930000744	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
374930000745	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cl00427
374930000746	ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116
374930000747	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099
374930000748	Walker A/P-loop; other site
374930000749	ATP binding site [chemical binding]; other site
374930000750	Q-loop/lid; other site
374930000751	ABC transporter signature motif; other site
374930000752	Walker B; other site
374930000753	D-loop; other site
374930000754	H-loop/switch region; other site
374930000755	Alpha-2,3-sialyltransferase (CST-I); Region: CST-I; pfam06002
374930000756	UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247
374930000757	UDP-glucose 4-epimerase; Region: PLN02240
374930000758	NAD binding site [chemical binding]; other site
374930000759	homodimer interface [polypeptide binding]; other site
374930000760	active site
374930000761	substrate binding site [chemical binding]; other site
374930000762	muropeptide transporter; Reviewed; Region: ampG; PRK11902
374930000763	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cl11420
374930000764	adenylate kinase; Reviewed; Region: adk; PRK00279
374930000765	Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428
374930000766	AMP-binding site [chemical binding]; other site
374930000767	ATP-AMP (Ap5A)-binding site [chemical binding]; other site
374930000768	Nitrate/TMAO reductases, membrane-bound tetraheme cytochrome c subunit [Energy production and conversion]; Region: TorC; COG3005
374930000769	cytochrome c-type protein NapC; Provisional; Region: PRK10617; cl09485
374930000770	Nitrate reductase cytochrome c-type subunit (NapB); Region: NapB; cl01153
374930000771	quinol dehydrogenase membrane component; Provisional; Region: napH; PRK09477
374930000772	4Fe-4S binding domain; Region: Fer4_5; pfam12801
374930000773	4Fe-4S binding domain; Region: Fer4; cl02805
374930000774	quinol dehydrogenase periplasmic component; Provisional; Region: napG; PRK09476
374930000775	nitrate reductase catalytic subunit; Provisional; Region: PRK13532
374930000776	NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol oxidation via a membrane-anchored...; Region: MopB_Nitrate-R-NapA-like; cd02754
374930000777	[4Fe-4S] binding site [ion binding]; other site
374930000778	molybdopterin cofactor binding site; other site
374930000779	NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol oxidation via a membrane-anchored...; Region: MopB_CT_Nitrate-R-NapA-like; cd02791
374930000780	molybdopterin cofactor binding site; other site
374930000781	NapD protein; Region: NapD; cl01163
374930000782	ferredoxin-type protein NapF; Region: napF; TIGR00402
374930000783	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved alpha-; Region: HCP_like; cl14655
374930000784	RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409
374930000785	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved alpha-; Region: HCP_like; cl14655
374930000786	4Fe-4S dicluster domain; Region: Fer4_7; pfam12838
374930000787	Protein with unknown function (DUF469); Region: DUF469; cl01237
374930000788	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011
374930000789	primosome assembly protein PriA; Validated; Region: PRK05580
374930000790	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
374930000791	ATP binding site [chemical binding]; other site
374930000792	putative Mg++ binding site [ion binding]; other site
374930000793	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl14882
374930000794	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
374930000795	Domain of unknown function DUF20; Region: UPF0118; cl00465
374930000796	Nitrogen regulatory protein P-II; Region: P-II; cl00412
374930000797	MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea...; Region: MogA_MoaB; cd00886
374930000798	MPT binding site; other site
374930000799	trimer interface [polypeptide binding]; other site
374930000800	Prokaryotic diacylglycerol kinase; Region: DAGK_prokar; cl00526
374930000801	(p)ppGpp synthetase I/GTP pyrophosphokinase; Provisional; Region: relA; PRK10872
374930000802	Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399
374930000803	synthetase active site [active]
374930000804	NTP binding site [chemical binding]; other site
374930000805	metal binding site [ion binding]; metal-binding site
374930000806	TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named...; Region: TGS_RelA_SpoT; cd01668
374930000807	ACT  domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876
374930000808	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins...; Region: HNHc; cl00083
374930000809	Molecular chaperone, HSP90 family [Posttranslational modification, protein turnover, chaperones]; Region: HtpG; COG0326
374930000810	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
374930000811	potential frameshift: common BLAST hit: gi|24378571|ref|NP_720526.1| putative site-specific DNA-methyltransferase
374930000812	potential frameshift: common BLAST hit: gi|68248938|ref|YP_248050.1| 23S rRNA (uracil-5-)-methyltransferase [Haemophilus influenzae]
374930000813	DNA repair protein RecO; Reviewed; Region: recO; PRK00085
374930000814	Recombination protein O N terminal; Region: RecO_N; pfam11967
374930000815	Recombination protein O C terminal; Region: RecO_C; pfam02565
374930000816	Cell envelope opacity-associated protein A [Cell envelope biogenesis, outer membrane]; Region: OapA; COG3061
374930000817	Opacity-associated protein A LysM-like domain; Region: OapA; pfam04225
374930000818	Lysine 2,3-aminomutase [Amino acid transport and metabolism]; Region: KamA; COG1509
374930000819	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster...; Region: Radical_SAM; cd01335
374930000820	FeS/SAM binding site; other site
374930000821	elongation factor P; Validated; Region: PRK00529
374930000822	Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207
374930000823	S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with N-formylmethionyl-...; Region: S1_EF-P_repeat_1; cd04470
374930000824	RNA binding site [nucleotide binding]; other site
374930000825	S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with N-formylmethionyl-...; Region: S1_EF-P_repeat_2; cd05794
374930000826	RNA binding site [nucleotide binding]; other site
374930000827	Primosomal replication protein priB and priC; Region: priB_priC; cl11483
374930000828	potential frameshift: common BLAST hit: gi|113461157|ref|YP_719225.1| possible permease [Haemophilus somnus 129PT]
374930000829	DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847
374930000830	DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012
374930000831	active site
374930000832	catalytic site [active]
374930000833	substrate binding site [chemical binding]; other site
374930000834	Glyoxalase I catalyzes the isomerization of the hemithioacetal, formed by a 2-oxoaldehyde and glutathione, to S-D-lactoylglutathione; Region: Glyoxalase_I; cd07233
374930000835	dimer interface [polypeptide binding]; other site
374930000836	active site
374930000837	metal binding site [ion binding]; metal-binding site
374930000838	glutathione binding site [chemical binding]; other site
374930000839	PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881
374930000840	oligomeric interface; other site
374930000841	putative active site [active]
374930000842	homodimer interface [polypeptide binding]; other site
374930000843	Virulence-associated protein and related proteins [Function unknown]; Region: VagC; COG4456
374930000844	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440
374930000845	S-adenosylmethionine binding site [chemical binding]; other site
374930000846	Isoprenylcysteine carboxyl methyltransferase (ICMT) family; Region: ICMT; cl00763
374930000847	aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476
374930000848	EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317
374930000849	dimer interface [polypeptide binding]; other site
374930000850	anticodon binding site; other site
374930000851	Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of the...; Region: AspRS_core; cd00777
374930000852	homodimer interface [polypeptide binding]; other site
374930000853	motif 1; other site
374930000854	active site
374930000855	motif 2; other site
374930000856	GAD domain; Region: GAD; pfam02938
374930000857	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
374930000858	active site
374930000859	motif 3; other site
374930000860	Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (...; Region: S24_LexA-like; cd06529
374930000861	Catalytic site [active]
374930000862	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801
374930000863	Integrase core domain; Region: rve; cl01316
374930000864	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
374930000865	helix-turn-helix, Psq domain; Region: HTH_psq; pfam05225
374930000866	Natural resistance-associated macrophage protein; Region: Nramp; cl00836
374930000867	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or...; Region: Nudix_Hydrolase; cl00447
374930000868	nudix motif; other site
374930000869	Domain of unknown function DUF28; Region: DUF28; cl00361
374930000870	Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination.  HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD includes...; Region: RuvC_resolvase; cd00529
374930000871	active site
374930000872	putative DNA-binding cleft [nucleotide binding]; other site
374930000873	dimer interface [polypeptide binding]; other site
374930000874	Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116
374930000875	RuvA N terminal domain; Region: RuvA_N; pfam01330
374930000876	RuvA, C-terminal domain; Region: RuvA_C; pfam07499
374930000877	Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080
374930000878	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009
374930000879	Walker A motif; other site
374930000880	ATP binding site [chemical binding]; other site
374930000881	Walker B motif; other site
374930000882	arginine finger; other site
374930000883	Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491
374930000884	site-specific tyrosine recombinase XerD; Reviewed; Region: xerD; PRK00283
374930000885	N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination of chromosomal replication, and stable plasmid...; Region: INT_XerDC; cd00798
374930000886	Int/Topo IB signature motif; other site
374930000887	active site
374930000888	phenyl proprionate permease family protein; Region: 2A0127; TIGR00902
374930000889	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
374930000890	putative substrate translocation pore; other site
374930000891	pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880
374930000892	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
374930000893	Putative exonuclease, RdgC; Region: RdgC; cl01122
374930000894	Uncharacterised protein family (UPF0081); Region: UPF0081; cl00525
374930000895	Uncharacterized ACR, COG1678; Region: DUF179; cl00731
374930000896	RNA methyltransferase; Region: Methyltrans_RNA; cl00611
374930000897	apolipoprotein N-acyltransferase; Reviewed; Region: lnt; PRK00302
374930000898	Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571
374930000899	putative active site [active]
374930000900	catalytic triad [active]
374930000901	putative dimer interface [polypeptide binding]; other site
374930000902	Putative Mg2+ and Co2+ transporter CorC [Inorganic ion transport and metabolism]; Region: CorC; COG4535
374930000903	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
374930000904	Transporter associated domain; Region: CorC_HlyC; pfam03471
374930000905	Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583
374930000906	amidase catalytic site [active]
374930000907	Zn binding residues [ion binding]; other site
374930000908	substrate binding site [chemical binding]; other site
374930000909	putative major pilin subunit; Provisional; Region: PRK10574
374930000910	Type II secretory pathway, ATPase PulE/Tfp pilus assembly pathway, ATPase PilB [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulE; COG2804
374930000911	GSPII_E N-terminal domain; Region: GSPII_E_N; pfam05157
374930000912	PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129
374930000913	Walker A motif; other site
374930000914	ATP binding site [chemical binding]; other site
374930000915	Walker B motif; other site
374930000916	Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459
374930000917	Bacterial type II secretion system protein F domain; Region: GSPII_F; cl00906
374930000918	Bacterial type II secretion system protein F domain; Region: GSPII_F; cl00906
374930000919	Type IV leader peptidase family; Region: Peptidase_A24; cl02077
374930000920	transcription termination factor Rho; Provisional; Region: rho; PRK09376
374930000921	Rho termination factor, N-terminal domain; Region: Rho_N; pfam07498
374930000922	Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent...; Region: Rho_CSD; cd04459
374930000923	RNA binding site [nucleotide binding]; other site
374930000924	Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of...; Region: rho_factor; cd01128
374930000925	multimer interface [polypeptide binding]; other site
374930000926	Walker A motif; other site
374930000927	ATP binding site [chemical binding]; other site
374930000928	Walker B motif; other site
374930000929	Met Repressor, MetJ.  MetJ is a bacterial regulatory protein that uses S-adenosylmethionine (SAM) as a corepressor to regulate the production of Methionine. MetJ binds arrays of two to five adjacent copies of an eight base-pair 'metbox' sequence; Region: Met_repressor_MetJ; cd00490
374930000930	dimerization interface [polypeptide binding]; other site
374930000931	DNA binding site [nucleotide binding]
374930000932	corepressor binding sites; other site
374930000933	Helix-Turn-Helix DNA binding domain of CueR-like transcription regulators; Region: HTH_CueR; cd01108
374930000934	Cu(I)-responsive transcriptional regulator; Region: CueR; TIGR02044
374930000935	DNA binding residues [nucleotide binding]
374930000936	dimer interface [polypeptide binding]; other site
374930000937	copper binding site [ion binding]; other site
374930000938	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
374930000939	metal-binding site [ion binding]
374930000940	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
374930000941	metal-binding site [ion binding]
374930000942	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
374930000943	metal-binding site [ion binding]
374930000944	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217
374930000945	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
374930000946	metal-binding site [ion binding]
374930000947	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
374930000948	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cl11391
374930000949	Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814
374930000950	Transmembrane amino acid transporter protein; Region: Aa_trans; cl00524
374930000951	L-serine dehydratase, iron-sulfur-dependent, single chain form; Region: sda_mono; TIGR00720
374930000952	Serine dehydratase beta chain; Region: SDH_beta; pfam03315
374930000953	Serine dehydratase alpha chain; Region: SDH_alpha; cl12120
374930000954	Transmembrane amino acid transporter protein; Region: Aa_trans; cl00524
374930000955	Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814
374930000956	tyrosine aminotransferase, eukaryotic; Region: tyr_amTase_E; TIGR01264
374930000957	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
374930000958	pyridoxal 5'-phosphate binding site [chemical binding]; other site
374930000959	homodimer interface [polypeptide binding]; other site
374930000960	catalytic residue [active]
374930000961	Isochorismate synthase [Coenzyme metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: MenF; COG1169
374930000962	chorismate binding enzyme; Region: Chorismate_bind; cl10555
374930000963	2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1- carboxylate synthase; Validated; Region: PRK07449
374930000964	Pyrimidine (PYR) binding domain of 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexadiene-1- carboxylate synthase (MenD) and related proteins; Region: TPP_PYR_MenD; cd07037
374930000965	dimer interface [polypeptide binding]; other site
374930000966	tetramer interface [polypeptide binding]; other site
374930000967	PYR/PP interface [polypeptide binding]; other site
374930000968	TPP binding site [chemical binding]; other site
374930000969	TPP-binding module; composed of proteins similar to Escherichia coli 2-succinyl-6-hydroxyl-2,4-cyclohexadiene-1-carboxylic acid (SHCHC) synthase (also called MenD). SHCHC synthase plays a key role in the menaquinone biosynthetic pathway, converting...; Region: TPP_SHCHC_synthase; cd02009
374930000970	TPP-binding site; other site
374930000971	2-succinyl-6-hydroxy-2, 4-cyclohexadiene-1-carboxylate synthase; Provisional; Region: PRK11126
374930000972	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
374930000973	metabolite-proton symporter; Region: 2A0106; TIGR00883
374930000974	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
374930000975	putative substrate translocation pore; other site
374930000976	Phosphorylase superfamily; Region: PNP_UDP_1; cl00303
374930000977	Uridine phosphorylase [Nucleotide transport and metabolism]; Region: Udp; COG2820
374930000978	MOSC domain; Region: MOSC; pfam03473
374930000979	hypothetical protein; Provisional; Region: PRK01752
374930000980	SEC-C motif; Region: SEC-C; cl12132
374930000981	SEC-C motif; Region: SEC-C; cl12132
374930000982	Ribonuclease BN-like family; Region: Ribonuclease_BN; cl07918
374930000983	Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368
374930000984	Sulfatase; Region: Sulfatase; cl10460
374930000985	glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406
374930000986	catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808
374930000987	HIGH motif; other site
374930000988	catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808
374930000989	active site
374930000990	KMSKS motif; other site
374930000991	ribonuclease PH; Reviewed; Region: rph; PRK00173
374930000992	3' exoribonuclease family, domain 1; Region: RNase_PH; pfam01138
374930000993	3' exoribonuclease family, domain 2; Region: RNase_PH_C; pfam03725
374930000994	Phosphoribosyl transferase domain; Region: Pribosyltran; cl00309
374930000995	Dna-J like membrane chaperone protein; Provisional; Region: djlA; PRK09430
374930000996	N-terminal tellurium resistance protein terB-like domain of heat shock DnaJ-like proteins; Region: terB_like_DjlA; cd07316
374930000997	putative metal binding site [ion binding]; other site
374930000998	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of...; Region: DnaJ; cd06257
374930000999	HSP70 interaction site [polypeptide binding]; other site
374930001000	Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and...; Region: DUS_like_FMN; cd02801
374930001001	Dihydrouridine synthase (Dus); Region: Dus; pfam01207
374930001002	FMN binding site [chemical binding]; other site
374930001003	active site
374930001004	catalytic residues [active]
374930001005	substrate binding site [chemical binding]; other site
374930001006	RNA polymerase factor sigma-32; Reviewed; Region: PRK06596
374930001007	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
374930001008	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial...; Region: Sigma70_r4; cl01055
374930001009	Uncharacterized protein conserved in bacteria (DUF2322); Region: DUF2322; cl01820
374930001010	UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK00046
374930001011	FAD binding domain; Region: FAD_binding_4; pfam01565
374930001012	UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873
374930001013	nitrate/nitrite sensor protein NarQ; Provisional; Region: PRK10935
374930001014	Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The...; Region: HAMP; cl01054
374930001015	Histidine kinase; Region: HisKA_3; pfam07730
374930001016	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
374930001017	ATP binding site [chemical binding]; other site
374930001018	Mg2+ binding site [ion binding]; other site
374930001019	G-X-G motif; other site
374930001020	Domain of unknown function (DUF205); Region: DUF205; cl00410
374930001021	Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines...; Region: DHNA_DHNTPE; cd00534
374930001022	homooctamer interface [polypeptide binding]; other site
374930001023	active site
374930001024	Large exoproteins involved in heme utilization or adhesion [Intracellular trafficking and secretion]; Region: FhaB; COG3210
374930001025	haemagglutination activity domain; Region: Haemagg_act; cl05436
374930001026	Hemolysin activation/secretion protein [Intracellular trafficking and secretion]; Region: FhaC; COG2831
374930001027	Surface antigen variable number repeat; Region: Surf_Ag_VNR; cl10520
374930001028	Surface antigen; Region: Bac_surface_Ag; cl03097
374930001029	TonB-dependent heme/hemoglobin receptor family protein; Region: TonB-hemin; TIGR01785
374930001030	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
374930001031	N-terminal plug; other site
374930001032	ligand-binding site [chemical binding]; other site
374930001033	potential frameshift: common BLAST hit: gi|16272219|ref|NP_438430.1| lipopolysaccharide biosynthesis protein [Haemophilus influenzae Rd]
374930001034	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
374930001035	ATP binding site [chemical binding]; other site
374930001036	NTPase/HAM1.  This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A Ham1-...; Region: HAM1; cd00515
374930001037	active site
374930001038	dimerization interface [polypeptide binding]; other site
374930001039	A4GalT_like proteins catalyze the addition of galactose or glucose residues to the lipooligosaccharide (LOS) or lipopolysaccharide (LPS) of the bacterial cell surface; Region: GT8_A4GalT_like; cd04194
374930001040	Ligand binding site [chemical binding]; other site
374930001041	metal binding site [ion binding]; metal-binding site
374930001042	RaiA ('ribosome-associated inhibitor A', also known as Protein Y (PY), YfiA, and SpotY,  is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal A site...; Region: RaiA; cd00552
374930001043	30S subunit binding site; other site
374930001044	NlpB/DapX lipoprotein; Region: Lipoprotein_18; pfam06804
374930001045	Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950
374930001046	dihydrodipicolinate synthase; Region: dapA; TIGR00674
374930001047	dimer interface [polypeptide binding]; other site
374930001048	active site
374930001049	catalytic residue [active]
374930001050	Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by...; Region: PRX_BCP; cd03017
374930001051	catalytic triad [active]
374930001052	MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568
374930001053	Biopolymer transport protein ExbD/TolR; Region: ExbD; cl00537
374930001054	Gram-negative bacterial tonB protein; Region: TonB; cl10048
374930001055	SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496
374930001056	dimer interface [polypeptide binding]; other site
374930001057	ssDNA binding site [nucleotide binding]; other site
374930001058	tetramer (dimer of dimers) interface [polypeptide binding]; other site
374930001059	potential frameshift: common BLAST hit: gi|16272207|ref|NP_438418.1| excinuclease ABC subunit A [Haemophilus influenzae Rd KW20]
374930001060	potential frameshift: common BLAST hit: gi|68248855|ref|YP_247967.1| adhesion and penetration protein Hap [Haemophilus influenzae]
374930001061	potential frameshift: common BLAST hit: gi|68248855|ref|YP_247967.1| adhesion and penetration protein Hap [Haemophilus influenzae]
374930001062	S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147
374930001063	Queuosine biosynthesis protein; Region: Queuosine_synth; cl00523
374930001064	Queuine tRNA-ribosyltransferase; Region: TGT; cl00409
374930001065	SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain.  SirA (also known as UvrY,  and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this two-...; Region: SirA_YedF_YeeD; cd00291
374930001066	CPxP  motif; other site
374930001067	Preprotein translocase subunit; Region: YajC; cl00806
374930001068	potential frameshift: common BLAST hit: gi|68248848|ref|YP_247960.1| protein export protein SecD [Haemophilus influenzae 86-028NP]
374930001069	preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022
374930001070	SecD/SecF GG Motif; Region: Sec_GG; pfam07549
374930001071	Protein export membrane protein; Region: SecD_SecF; cl14618
374930001072	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
374930001073	Domain of unknown function DUF20; Region: UPF0118; cl00465
374930001074	Arsenate Reductase (ArsC) family, ArsC subfamily; arsenic reductases similar to that encoded by arsC on the R733 plasmid of Escherichia coli. E. coli ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], the first step in the...; Region: ArsC_ArsC; cd03034
374930001075	catalytic residues [active]
374930001076	Domain of unknown function; Region: DUF331; cl01149
374930001077	membrane-bound lytic transglycosylase F; Provisional; Region: PRK10859
374930001078	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and...; Region: PBPb; cd00134
374930001079	substrate binding pocket [chemical binding]; other site
374930001080	membrane-bound complex binding site; other site
374930001081	hinge residues; other site
374930001082	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic 'goose-type' lysozymes (GEWL).  LTs catalyze...; Region: LT_GEWL; cd00254
374930001083	N-acetyl-D-glucosamine binding site [chemical binding]; other site
374930001084	catalytic residue [active]
374930001085	ATP-dependent RNA helicase DeaD; Provisional; Region: PRK11634
374930001086	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif (...; Region: DEADc; cd00268
374930001087	ATP binding site [chemical binding]; other site
374930001088	Mg++ binding site [ion binding]; other site
374930001089	motif III; other site
374930001090	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
374930001091	nucleotide binding region [chemical binding]; other site
374930001092	ATP-binding site [chemical binding]; other site
374930001093	DbpA RNA binding domain; Region: DbpA; pfam03880
374930001094	lipoprotein NlpI; Provisional; Region: PRK11189
374930001095	polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824
374930001096	3' exoribonuclease family, domain 1; Region: RNase_PH; pfam01138
374930001097	3' exoribonuclease family, domain 2; Region: RNase_PH_C; pfam03725
374930001098	Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726
374930001099	3' exoribonuclease family, domain 1; Region: RNase_PH; pfam01138
374930001100	3' exoribonuclease family, domain 2; Region: RNase_PH_C; pfam03725
374930001101	Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393
374930001102	putative nucleic acid binding region [nucleotide binding]; other site
374930001103	G-X-X-G motif; other site
374930001104	S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase  is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA...; Region: S1_PNPase; cd04472
374930001105	RNA binding site [nucleotide binding]; other site
374930001106	domain interface; other site
374930001107	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
374930001108	Domain of unknown function (DUF386); Region: DUF386; cl01047
374930001109	Branched-chain amino acid transport protein; Region: Branch_AA_trans; cl00547
374930001110	Na+/H+ antiporter 1; Region: Na_H_antiport_1; cl01133
374930001111	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
374930001112	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088
374930001113	Predicted permeases [General function prediction only]; Region: RarD; COG2962
374930001114	GMP synthase; Reviewed; Region: guaA; PRK00074
374930001115	Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742
374930001116	AMP/PPi binding site [chemical binding]; other site
374930001117	candidate oxyanion hole; other site
374930001118	catalytic triad [active]
374930001119	potential glutamine specificity residues [chemical binding]; other site
374930001120	The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997
374930001121	ATP Binding subdomain [chemical binding]; other site
374930001122	Ligand Binding sites [chemical binding]; other site
374930001123	Dimerization subdomain; other site
374930001124	inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567
374930001125	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl09108
374930001126	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a key...; Region: CBS_pair_IMPDH; cd04601
374930001127	IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of the...; Region: IMPDH; cd00381
374930001128	active site
374930001129	bifunctional biotin--[acetyl-CoA-carboxylase] synthetase/biotin operon repressor; Provisional; Region: PRK11886
374930001130	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088
374930001131	Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057
374930001132	Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237
374930001133	Phosphate-starvation-inducible E; Region: PsiE; cl01264
374930001134	hemY protein; Region: hemY_coli; TIGR00540
374930001135	HemY protein N-terminus; Region: HemY_N; pfam07219
374930001136	Uncharacterized enzyme of heme biosynthesis [Coenzyme metabolism]; Region: HemX; COG2959
374930001137	HemX; Region: HemX; cl14667
374930001138	Adenylate cyclase [Nucleotide transport and metabolism]; Region: CyaA; COG3072
374930001139	Adenylate cyclase NT domain; Region: Adenyl_cycl_N; pfam12633
374930001140	Adenylate cyclase, class-I; Region: Adenylate_cycl; pfam01295
374930001141	NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094
374930001142	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
374930001143	NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479
374930001144	serine acetyltransferase; Provisional; Region: cysE; PRK11132
374930001145	Serine acetyltransferase, N-terminal; Region: SATase_N; pfam06426
374930001146	Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of L-...; Region: LbH_SAT; cd03354
374930001147	trimer interface [polypeptide binding]; other site
374930001148	active site
374930001149	substrate binding site [chemical binding]; other site
374930001150	CoA binding site [chemical binding]; other site
374930001151	shikimate 5-dehydrogenase; Reviewed; Region: PRK12550
374930001152	Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501
374930001153	NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065
374930001154	shikimate binding site; other site
374930001155	NAD(P) binding site [chemical binding]; other site
374930001156	Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471
374930001157	Permease SLC13 (solute carrier 13).  The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115
374930001158	transmembrane helices; other site
374930001159	bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK10792
374930001160	Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763
374930001161	NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080
374930001162	homodimer interface [polypeptide binding]; other site
374930001163	NADP binding site [chemical binding]; other site
374930001164	substrate binding site [chemical binding]; other site
374930001165	potential frameshift: common BLAST hit: gi|68249309|ref|YP_248421.1| L-fucose permease [Haemophilus influenzae 86-028NP]
374930001166	Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II)...; Region: Aldolase_II; cd00398
374930001167	intersubunit interface [polypeptide binding]; other site
374930001168	active site
374930001169	Zn2+ binding site [ion binding]; other site
374930001170	RbsD / FucU transport protein family; Region: RbsD_FucU; cl00809
374930001171	L-fuculokinase; Region: fuculo_kin_coli; TIGR02628
374930001172	FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121
374930001173	FGGY family of carbohydrate kinases, C-terminal domain; Region: FGGY_C; pfam02782
374930001174	L-fucose isomerase; Provisional; Region: fucI; PRK10991
374930001175	L-fucose isomerase (FucIase) and L-arabinose isomerase (AI) family; composed of FucIase, AI and similar proteins. FucIase converts L-fucose, an aldohexose, to its ketose form, which prepares it for aldol cleavage (similar to the isomerization of...; Region: L-fuc_L-ara-isomerases; cl00947
374930001176	hexamer (dimer of trimers) interface [polypeptide binding]; other site
374930001177	trimer interface [polypeptide binding]; other site
374930001178	substrate binding site [chemical binding]; other site
374930001179	Mn binding site [ion binding]; other site
374930001180	Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349
374930001181	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088
374930001182	SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339
374930001183	ATP-dependent helicase HepA; Validated; Region: PRK04914
374930001184	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
374930001185	ATP binding site [chemical binding]; other site
374930001186	putative Mg++ binding site [ion binding]; other site
374930001187	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
374930001188	nucleotide binding region [chemical binding]; other site
374930001189	ATP-binding site [chemical binding]; other site
374930001190	PseudoU_synth_RsuA/RluD: Pseudouridine synthase, RsuA/RluD family. This group is comprised of eukaryotic, bacterial and archeal proteins similar to eight site specific Escherichia coli pseudouridine synthases: RsuA, RluA, RluB, RluC, RluD, RluE, RluF...; Region: PseudoU_synth_RluCD_like; cd02869
374930001191	active site
374930001192	Rhomboid family; Region: Rhomboid; cl11446
374930001193	DNA-binding transcriptional repressor GlpR; Provisional; Region: PRK10906
374930001194	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088
374930001195	SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339
374930001196	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
374930001197	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261
374930001198	dimer interface [polypeptide binding]; other site
374930001199	conserved gate region; other site
374930001200	ABC-ATPase subunit interface; other site
374930001201	DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153
374930001202	MetN (also known as YusC) is an ABC-type transporter encoded by metN of the metNPQ operon in Bacillus subtilis that is involved in methionine transport.  Other members of this system include the MetP permease and  the MetQ substrate binding protein; Region: ABC_MetN_methionine_transporter; cd03258
374930001203	Walker A/P-loop; other site
374930001204	ATP binding site [chemical binding]; other site
374930001205	Q-loop/lid; other site
374930001206	ABC transporter signature motif; other site
374930001207	Walker B; other site
374930001208	D-loop; other site
374930001209	H-loop/switch region; other site
374930001210	NIL domain; Region: NIL; pfam09383
374930001211	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cd01427
374930001212	active site
374930001213	motif I; other site
374930001214	motif II; other site
374930001215	Predicted sugar phosphatases of the HAD superfamily [Carbohydrate transport and metabolism]; Region: NagD; COG0647
374930001216	Uracil DNA glycosylase superfamily; Region: UDG; cl00483
374930001217	potential frameshift: common BLAST hit: gi|68248825|ref|YP_247937.1| putative type I restriction-modification system [Haemophilus]
374930001218	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4694
374930001219	Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420
374930001220	Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732
374930001221	Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420
374930001222	type I restriction system adenine methylase (hsdM); Region: hsdM; TIGR00497
374930001223	HsdM N-terminal domain; Region: HsdM_N; pfam12161
374930001224	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011
374930001225	Zn-dependent oligopeptidases [Amino acid transport and metabolism]; Region: Dcp; COG0339
374930001226	Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456
374930001227	active site
374930001228	Zn binding site [ion binding]; other site
374930001229	Protein of unknown function (DUF454); Region: DUF454; cl01063
374930001230	ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166
374930001231	The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504
374930001232	peptide binding site [polypeptide binding]; other site
374930001233	GTP cyclohydrolase II [Coenzyme metabolism]; Region: RibA; COG0807
374930001234	GTP cyclohydrolase II (RibA).  GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641
374930001235	dimerization interface [polypeptide binding]; other site
374930001236	active site
374930001237	PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392
374930001238	active site
374930001239	potential frameshift: common BLAST hit: gi|68248814|ref|YP_247926.1| DNA adenine methylase [Haemophilus influenzae 86-028NP]
374930001240	potential frameshift: common BLAST hit: gi|68248814|ref|YP_247926.1| DNA adenine methylase [Haemophilus influenzae 86-028NP]
374930001241	Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195
374930001242	Iron-containing alcohol dehydrogenase; Region: Fe-ADH; pfam00465
374930001243	active site
374930001244	dimer interface [polypeptide binding]; other site
374930001245	metal binding site [ion binding]; metal-binding site
374930001246	shikimate kinase; Reviewed; Region: aroK; PRK00131
374930001247	Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the...; Region: SK; cd00464
374930001248	ADP binding site [chemical binding]; other site
374930001249	magnesium binding site [ion binding]; other site
374930001250	putative shikimate binding site; other site
374930001251	NAD pyrophosphatase/5'-nucleotidase NadN; Region: nadN; TIGR01530
374930001252	CD73 ecto-5'-nucleotidase and related proteins, N-terminal metallophosphatase domain; Region: MPP_CD73_N; cd07409
374930001253	active site
374930001254	metal binding site [ion binding]; metal-binding site
374930001255	5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872
374930001256	Ribosomal protein S16; Region: Ribosomal_S16; cl00368
374930001257	16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122
374930001258	RimM N-terminal domain; Region: RimM; pfam01782
374930001259	Photosynthetic reaction center (RC) complex, subunit H;  RC is an integral membrane protein-pigment complex which catalyzes light-induced reduction of ubiquinone to ubiquinol, generating a transmembrane electrochemical gradient of protons used to...; Region: PRCH; cl09959
374930001260	tRNA (Guanine-1)-methyltransferase; Region: tRNA_m1G_MT; cl00407
374930001261	Ribosomal protein L19; Region: Ribosomal_L19; cl00406
374930001262	potential frameshift: common BLAST hit: gi|68248805|ref|YP_247917.1| selenide, water dikinase [Haemophilus influenzae 86-028NP]
374930001263	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984
374930001264	putative acyl-acceptor binding pocket; other site
374930001265	Predicted permeases [General function prediction only]; Region: COG0730; cl00498
374930001266	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
374930001267	Murein endopeptidase [Cell envelope biogenesis, outer membrane]; Region: MepA; COG3770
374930001268	Penicillin-insensitive murein endopeptidase; Region: Peptidase_M74; cl01538
374930001269	Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304
374930001270	Tetramer interface [polypeptide binding]; other site
374930001271	Active site [active]
374930001272	FMN-binding site [chemical binding]; other site
374930001273	hypothetical protein; Provisional; Region: PRK11281
374930001274	Mechanosensitive ion channel inner membrane domain 1; Region: MscS_TM; pfam12794
374930001275	Mechanosensitive ion channel; Region: MS_channel; pfam00924
374930001276	O-succinylbenzoic acid--CoA ligase; Provisional; Region: PRK09029
374930001277	Acyl-protein synthetase, LuxE; Region: LuxE; cl10450
374930001278	potential frameshift: common BLAST hit: gi|68248798|ref|YP_247910.1| SeqA [Haemophilus influenzae 86-028NP]
374930001279	acyl-CoA esterase; Provisional; Region: PRK10673
374930001280	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
374930001281	NADPH-dependent FMN reductase; Region: FMN_red; cl00438
374930001282	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153
374930001283	metal binding site 2 [ion binding]; metal-binding site
374930001284	putative DNA binding helix; other site
374930001285	metal binding site 1 [ion binding]; metal-binding site
374930001286	dimer interface [polypeptide binding]; other site
374930001287	structural Zn2+ binding site [ion binding]; other site
374930001288	glutamate dehydrogenase; Provisional; Region: PRK09414
374930001289	Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812
374930001290	NAD(P) binding domain of glutamate dehydrogenase, subgroup 2; Region: NAD_bind_2_Glu_DH; cd05313
374930001291	NAD(P) binding site [chemical binding]; other site
374930001292	Sec-independent protein translocase protein (TatC); Region: TatC; cl00521
374930001293	mttA/Hcf106 family; Region: MttA_Hcf106; cl00788
374930001294	mttA/Hcf106 family; Region: MttA_Hcf106; cl00788
374930001295	Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789
374930001296	Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109
374930001297	DNA binding residues [nucleotide binding]
374930001298	putative dimer interface [polypeptide binding]; other site
374930001299	class III alcohol dehydrogenases; Region: alcohol_DH_class_III; cd08300
374930001300	S-(hydroxymethyl)glutathione dehydrogenase/class III alcohol dehydrogenase; Region: adh_III_F_hyde; TIGR02818
374930001301	substrate binding site [chemical binding]; other site
374930001302	catalytic Zn binding site [ion binding]; other site
374930001303	NAD binding site [chemical binding]; other site
374930001304	structural Zn binding site [ion binding]; other site
374930001305	dimer interface [polypeptide binding]; other site
374930001306	Predicted esterase [General function prediction only]; Region: COG0627
374930001307	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
374930001308	potential frameshift: common BLAST hit: gi|59800725|ref|YP_207437.1| IgA-specific metalloendopeptidase [Neisseria gonorrhoeae FA 1090]
374930001309	Na(+)-translocating NADH-quinone reductase subunit A; Provisional; Region: PRK05352
374930001310	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
374930001311	E3 interaction surface; other site
374930001312	lipoyl attachment site [posttranslational modification]; other site
374930001313	NQRA C-terminal domain; Region: NQRA_SLBB; pfam11973
374930001314	RnfE family; Region: NQR2_RnfD_RnfE; cl00779
374930001315	Na+-transporting NADH:ubiquinone oxidoreductase, subunit NqrC [Energy production and conversion]; Region: NqrC; COG2869
374930001316	FMN-binding domain; Region: FMN_bind; cl01081
374930001317	Rnf-Nqr subunit, membrane protein; Region: Rnf-Nqr; cl00597
374930001318	Rnf-Nqr subunit, membrane protein; Region: Rnf-Nqr; cl00597
374930001319	Na(+)-translocating NADH-quinone reductase subunit F; Provisional; Region: PRK05464
374930001320	Na+-translocating NADH:quinone oxidoreductase (Na+-NQR) FAD/NADH binding domain. (Na+-NQR) provides a means of storing redox reaction energy via the transmembrane translocation of Na2+ ions. The C-terminal domain resembles ferredoxin:NADP+...; Region: NADH_quinone_reductase; cd06188
374930001321	FAD binding pocket [chemical binding]; other site
374930001322	FAD binding motif [chemical binding]; other site
374930001323	phosphate binding motif [ion binding]; other site
374930001324	beta-alpha-beta structure motif; other site
374930001325	NAD binding pocket [chemical binding]; other site
374930001326	ApbE family; Region: ApbE; cl00643
374930001327	Protein of unknown function (DUF539); Region: DUF539; cl01129
374930001328	potential frameshift: common BLAST hit: gi|68248779|ref|YP_247891.1| tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase
374930001329	Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496
374930001330	Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; cl00650
374930001331	23S rRNA pseudouridine synthase D; Provisional; Region: rluD; PRK11180
374930001332	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
374930001333	RNA binding surface [nucleotide binding]; other site
374930001334	PseudoU_synth_RsuA/RluD: Pseudouridine synthase, RsuA/RluD family. This group is comprised of eukaryotic, bacterial and archeal proteins similar to eight site specific Escherichia coli pseudouridine synthases: RsuA, RluA, RluB, RluC, RluD, RluE, RluF...; Region: PseudoU_synth_RluCD_like; cd02869
374930001335	active site
374930001336	outer membrane assembly lipoprotein YfiO; Region: OM_YfiO; TIGR03302
374930001337	potential frameshift: common BLAST hit: gi|68248784|ref|YP_247896.1| pyruvate formate-lyase 1 activating enzyme [Haemophilus influenzae]
374930001338	formate acetyltransferase 1; Region: pyr_form_ly_1; TIGR01255
374930001339	Pyruvate formate lyase 1; Region: PFL1; cd01678
374930001340	coenzyme A binding site [chemical binding]; other site
374930001341	active site
374930001342	catalytic residues [active]
374930001343	glycine loop; other site
374930001344	Formate/nitrite transporter; Region: Form_Nir_trans; cl00927
374930001345	FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121
374930001346	fructokinase; Reviewed; Region: PRK09557
374930001347	Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548
374930001348	BolA-like protein; Region: BolA; cl00386
374930001349	Uncharacterized lipoprotein [Cell envelope biogenesis, outer membrane]; Region: COG3056
374930001350	Uncharacterized lipoprotein; Region: Lipoprotein_16; pfam03923
374930001351	glutathione reductase; Validated; Region: PRK06116
374930001352	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644
374930001353	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
374930001354	Phosphatidylserine decarboxylase; Region: PS_Dcarbxylase; cl03656
374930001355	Uncharacterized ACR, COG1399; Region: DUF177; cl00616
374930001356	Ribosomal L32p protein family; Region: Ribosomal_L32p; cl09115
374930001357	3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352
374930001358	Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830
374930001359	dimer interface [polypeptide binding]; other site
374930001360	active site
374930001361	CoA binding pocket [chemical binding]; other site
374930001362	Acyl transferase domain; Region: Acyl_transf_1; cl08282
374930001363	malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128
374930001364	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557
374930001365	beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333
374930001366	NAD(P) binding site [chemical binding]; other site
374930001367	homotetramer interface [polypeptide binding]; other site
374930001368	homodimer interface [polypeptide binding]; other site
374930001369	active site
374930001370	Phosphopantetheine attachment site; Region: PP-binding; cl09936
374930001371	Anaerobic c4-dicarboxylate membrane transporter; Region: DcuA_DcuB; cl01040
374930001372	Phosphopantetheinyl transferase [Coenzyme metabolism]; Region: Sfp; COG2091
374930001373	4'-phosphopantetheinyl transferase superfamily; Region: ACPS; cl00500
374930001374	FtsH protease regulator HflK; Provisional; Region: PRK10930
374930001375	Band_7_HflK: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfK (High frequency of lysogenization K). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflK; cd03404
374930001376	FtsH protease regulator HflC; Provisional; Region: PRK11029
374930001377	Band_7_HflC: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfC (High frequency of lysogenization C). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflC; cd03405
374930001378	Isoprenylcysteine carboxyl methyltransferase (ICMT) family; Region: ICMT; cl00763
374930001379	N-acetylneuraminic acid mutarotase; Provisional; Region: PRK14131
374930001380	Kelch motif; Region: Kelch_1; cl02701
374930001381	Tripartite ATP-independent periplasmic transporters, DctQ component; Region: DctQ; cl01181
374930001382	DctM-like transporters; Region: DctM; pfam06808
374930001383	Anion permease ArsB/NhaD.  These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life.  A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl09110
374930001384	Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl00710
374930001385	N-acetylmannosamine-6-phosphate epimerase (NanE) converts N-acetylmannosamine-6-phosphate to N-acetylglucosamine-6-phosphate. This reaction is part of the pathway that allows the usage of sialic acid as a carbohydrate source. Sialic acids are a family...; Region: NanE; cd04729
374930001386	N-acetylmannosamine-6-phosphate 2-epimerase; Provisional; Region: PRK01130
374930001387	putative active site cavity [active]
374930001388	N-acetylmannosamine kinase; Provisional; Region: PRK05082
374930001389	FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121
374930001390	Transcriptional regulators [Transcription]; Region: RpiR; COG1737
374930001391	RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose...; Region: SIS_RpiR; cd05013
374930001392	putative active site [active]
374930001393	N-acetylneuraminate lyase; Region: nanA; TIGR00683
374930001394	N-Acetylneuraminic acid aldolase, also called N-acetylneuraminate lyase (NAL); Region: NAL; cd00954
374930001395	inhibitor site; inhibition site
374930001396	active site
374930001397	dimer interface [polypeptide binding]; other site
374930001398	catalytic residue [active]
374930001399	GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination...; Region: GlcN6P_deaminase; cd01399
374930001400	active site
374930001401	trimer interface [polypeptide binding]; other site
374930001402	allosteric site; other site
374930001403	active site lid [active]
374930001404	hexamer (dimer of trimers) interface [polypeptide binding]; other site
374930001405	N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854
374930001406	active site
374930001407	dimer interface [polypeptide binding]; other site
374930001408	Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface...; Region: gram_neg_porins; cd00342
374930001409	trimer interface [polypeptide binding]; other site
374930001410	eyelet of channel; other site
374930001411	RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278
374930001412	RNA/DNA hybrid binding site [nucleotide binding]; other site
374930001413	active site
374930001414	exonuclease, DNA polymerase III, epsilon subunit family; Region: dnaq; TIGR00573
374930001415	DEDDh 3'-5' exonuclease domain of the epsilon subunit of Escherichia coli DNA polymerase III and similar proteins; Region: DNA_pol_III_epsilon_Ecoli_like; cd06131
374930001416	active site
374930001417	substrate binding site [chemical binding]; other site
374930001418	catalytic site [active]
374930001419	GTP-binding protein Der; Reviewed; Region: PRK00093
374930001420	EngA1 subfamily.  This CD represents the first GTPase domain of EngA and its orthologs, which are composed of two adjacent GTPase domains.  Since the sequences of the two domains are more similar to each other than to other GTPases, it is likely that...; Region: EngA1; cd01894
374930001421	G1 box; other site
374930001422	GTP/Mg2+ binding site [chemical binding]; other site
374930001423	Switch I region; other site
374930001424	G2 box; other site
374930001425	Switch II region; other site
374930001426	G3 box; other site
374930001427	G4 box; other site
374930001428	G5 box; other site
374930001429	EngA2 subfamily.  This CD represents the second GTPase domain of EngA and its orthologs, which are composed of two adjacent GTPase domains.  Since the sequences of the two domains are more similar to each other than to other GTPases, it is likely that...; Region: EngA2; cd01895
374930001430	G1 box; other site
374930001431	GTP/Mg2+ binding site [chemical binding]; other site
374930001432	Switch I region; other site
374930001433	G2 box; other site
374930001434	G3 box; other site
374930001435	Switch II region; other site
374930001436	G4 box; other site
374930001437	G5 box; other site
374930001438	potential frameshift: common BLAST hit: gi|68248743|ref|YP_247855.1| sugar efflux transporter [Haemophilus influenzae 86-028NP]
374930001439	2'-deoxycytidine 5'-triphosphate deaminase (DCD); Region: DCD; pfam06559
374930001440	Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557
374930001441	trimer interface [polypeptide binding]; other site
374930001442	active site
374930001443	Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage...; Region: UMPK; cd02023
374930001444	Sugar specificity; other site
374930001445	Pyrimidine base specificity; other site
374930001446	ATP-binding site [chemical binding]; other site
374930001447	Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412
374930001448	dimer interface [polypeptide binding]; other site
374930001449	substrate binding site [chemical binding]; other site
374930001450	metal binding sites [ion binding]; metal-binding site
374930001451	CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453
374930001452	cystathionine beta-lyase; Provisional; Region: PRK08114
374930001453	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
374930001454	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
374930001455	catalytic residue [active]
374930001456	UDP-N-acetylmuramate:L-alanyl-gamma-D-glutamyl- meso-diaminopimelate ligase; Region: mpl; TIGR01081
374930001457	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
374930001458	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
374930001459	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
374930001460	Uncharacterized integral membrane protein (DUF2301); Region: DUF2301; cl02241
374930001461	Zinc binding protein ZnuA. These proteins have been shown to function as initial receptors in the ABC uptake of Zn2+.  They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct fold and ligand binding mechanism; Region: ZnuA; cd01019
374930001462	Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297
374930001463	metal binding site [ion binding]; metal-binding site
374930001464	Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 1 [Coenzyme metabolism]; Region: COG1179
374930001465	Family of activating enzymes (E1) of ubiquitin-like proteins related to the E.coli hypothetical protein ygdL. The common reaction mechanism catalyzed by E1-like enzymes begins with a nucleophilic attack of the C-terminal carboxylate of the ubiquitin-...; Region: YgdL_like; cd00755
374930001466	putative ATP binding site [chemical binding]; other site
374930001467	putative substrate interface [chemical binding]; other site
374930001468	murein transglycosylase A; Provisional; Region: mltA; PRK11162
374930001469	MltA specific insert domain; Region: MltA; pfam03562
374930001470	3D domain; Region: 3D; cl01439
374930001471	23S rRNA m(2)G2445 methyltransferase; Provisional; Region: rlmL; PRK11783
374930001472	THUMP domain; Region: THUMP; cl12076
374930001473	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011
374930001474	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011
374930001475	potential frameshift: common BLAST hit: gi|68248728|ref|YP_247840.1| hemin receptor [Haemophilus influenzae 86-028NP]
374930001476	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
374930001477	GST_N family, Class Beta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens...; Region: GST_N_Beta; cd03057
374930001478	C-terminal domain interface [polypeptide binding]; other site
374930001479	GSH binding site (G-site) [chemical binding]; other site
374930001480	dimer interface [polypeptide binding]; other site
374930001481	GST_C family, Class Beta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens...; Region: GST_C_Beta; cd03188
374930001482	dimer interface [polypeptide binding]; other site
374930001483	N-terminal domain interface [polypeptide binding]; other site
374930001484	substrate binding pocket (H-site) [chemical binding]; other site
374930001485	seryl-tRNA synthetase; Provisional; Region: PRK05431
374930001486	Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403
374930001487	Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770
374930001488	dimer interface [polypeptide binding]; other site
374930001489	active site
374930001490	motif 1; other site
374930001491	motif 2; other site
374930001492	motif 3; other site
374930001493	Protein of unknown function (DUF1212); Region: DUF1212; cl01118
374930001494	Putative Mg2+ and Co2+ transporter CorB [Inorganic ion transport and metabolism]; Region: CorB; COG4536
374930001495	Domain of unknown function DUF21; Region: DUF21; pfam01595
374930001496	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
374930001497	Transporter associated domain; Region: CorC_HlyC; pfam03471
374930001498	signal recognition particle protein; Provisional; Region: PRK10867
374930001499	SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881
374930001500	The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115
374930001501	P loop; other site
374930001502	GTP binding site [chemical binding]; other site
374930001503	Signal peptide binding domain; Region: SRP_SPB; pfam02978
374930001504	Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: COG0610
374930001505	Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313
374930001506	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl14882
374930001507	Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420
374930001508	Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420
374930001509	Divergent AAA domain; Region: AAA_4; pfam04326
374930001510	Predicted transcriptional regulator containing an HTH domain and an uncharacterized domain shared with the mammalian protein Schlafen [Transcription]; Region: COG2865
374930001511	Type I restriction-modification system methyltransferase subunit [Defense mechanisms]; Region: HsdM; COG0286
374930001512	HsdM N-terminal domain; Region: HsdM_N; pfam12161
374930001513	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011
374930001514	Uncharacterized conserved protein [Function unknown]; Region: COG0327
374930001515	NIF3 (NGG1p interacting factor 3); Region: NIF3; cl01309
374930001516	heat shock protein 90; Provisional; Region: PRK05218
374930001517	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
374930001518	ATP binding site [chemical binding]; other site
374930001519	Mg2+ binding site [ion binding]; other site
374930001520	G-X-G motif; other site
374930001521	Arsenate Reductase (ArsC) family, Yffb subfamily; Yffb is an uncharacterized bacterial protein encoded by the yffb gene, related to the thioredoxin-fold arsenic reductases, ArsC. The structure of Yffb and the conservation of the catalytic cysteine...; Region: ArsC_Yffb; cd03035
374930001522	putative catalytic residues [active]
374930001523	succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK13009
374930001524	M20 Peptidase proteobacterial DapE encoded N-succinyl-L,L-diaminopimelic acid desuccinylase; Region: M20_DapE_proteobac; cd03891
374930001525	metal binding site [ion binding]; metal-binding site
374930001526	dimer interface [polypeptide binding]; other site
374930001527	D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: VanY; COG1876
374930001528	D-alanyl-D-alanine carboxypeptidase; Region: VanY; cl00813
374930001529	ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842
374930001530	ABC Carbohydrate and Solute Transporters-like subgroup.  This family is comprised of proteins involved in the transport of apparently unrelated solutes and proteins specific for di- and oligosaccharides and polyols.  ABC transporters are a large family...; Region: ABC_Carb_Solutes_like; cd03259
374930001531	Walker A/P-loop; other site
374930001532	ATP binding site [chemical binding]; other site
374930001533	Q-loop/lid; other site
374930001534	ABC transporter signature motif; other site
374930001535	Walker B; other site
374930001536	D-loop; other site
374930001537	H-loop/switch region; other site
374930001538	potential frameshift: common BLAST hit: gi|30995355|ref|NP_438272.2| iron(III) ABC transporter permease protein [Haemophilus influenzae]
374930001539	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
374930001540	SAM-dependent methyltransferases [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: SmtA; COG0500
374930001541	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440
374930001542	S-adenosylmethionine binding site [chemical binding]; other site
374930001543	Anion permease ArsB/NhaD.  These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life.  A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl09110
374930001544	Glycerate kinase family; Region: Gly_kinase; cl00841
374930001545	Pyridoxal 5-phosphate (PLP)-binding TIM barrel domain of Type III PLP-Dependent Enzymes, Yggs-like proteins; Region: PLPDE_III_Yggs_like; cd06824
374930001546	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
374930001547	catalytic residue [active]
374930001548	bifunctional aspartokinase I/homoserine dehydrogenase I; Provisional; Region: thrA; PRK09436
374930001549	AAK_AK-HSDH: Amino Acid Kinase Superfamily (AAK), AK-HSDH; this CD includes the N-terminal catalytic domain of aspartokinase (AK) of the bifunctional enzyme AK - homoserine dehydrogenase (HSDH). These aspartokinases are found in bacteria (E. coli AKI-...; Region: AAK_AK-HSDH; cd04257
374930001550	putative catalytic residues [active]
374930001551	putative nucleotide binding site [chemical binding]; other site
374930001552	putative aspartate binding site [chemical binding]; other site
374930001553	ACT domains of the bifunctional enzyme aspartokinase (AK) - homoserine dehydrogenase (HSDH); Region: ACT_AKi-HSDH-ThrA-like_1; cd04921
374930001554	dimer interface [polypeptide binding]; other site
374930001555	putative threonine allosteric regulatory site; other site
374930001556	ACT domains of the bifunctional enzyme aspartokinase (AK) - homoserine dehydrogenase (HSDH); Region: ACT_AKi-HSDH-ThrA_2; cd04922
374930001557	putative threonine allosteric regulatory site; other site
374930001558	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
374930001559	Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742
374930001560	homoserine kinase; Region: thrB; TIGR00191
374930001561	GHMP kinases N terminal domain; Region: GHMP_kinases_N; cl08256
374930001562	GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544
374930001563	Threonine synthase [Amino acid transport and metabolism]; Region: ThrC; COG0498
374930001564	Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD)...; Region: Trp-synth-beta_II; cl00342
374930001565	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
374930001566	catalytic residue [active]
374930001567	cystathionine gamma-synthase; Reviewed; Region: PRK08247
374930001568	CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614
374930001569	homodimer interface [polypeptide binding]; other site
374930001570	substrate-cofactor binding pocket; other site
374930001571	pyridoxal 5'-phosphate binding site [chemical binding]; other site
374930001572	catalytic residue [active]
374930001573	potential frameshift: common BLAST hit: gi|68248635|ref|YP_247747.1| D-lactate dehydrogenase [Haemophilus influenzae 86-028NP]
374930001574	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
374930001575	catalytic residues [active]
374930001576	The URO-D_CIMS_like protein superfamily includes bacterial and eukaryotic uroporphyrinogen decarboxylases (URO-D), coenzyme M methyltransferases and other putative bacterial methyltransferases, as well as cobalamine (B12) independent methionine...; Region: URO-D_CIMS_like; cl00464
374930001577	TatD like proteins;  E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310
374930001578	putative deoxyribonuclease YjjV; Provisional; Region: PRK11449
374930001579	active site
374930001580	cyclophilin_EcCYP_like: cyclophilin-type A-like peptidylprolyl cis- trans isomerase (PPIase) domain similar to the cytosolic E. coli cyclophilin A and Streptomyces antibioticus SanCyp18. Compared to the archetypal cyclophilin Human cyclophilin A, these...; Region: cyclophilin_EcCYP_like; cd01920
374930001581	substrate binding site [chemical binding]; other site
374930001582	potential frameshift: common BLAST hit: gi|68248628|ref|YP_247740.1| cysteinyl-tRNA synthetase [Haemophilus influenzae 86-028NP]
374930001583	Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657
374930001584	dinuclear metal binding motif [ion binding]; other site
374930001585	Acyl-CoA thioesterase [Lipid metabolism]; Region: TesB; COG1946
374930001586	Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat2; cd03445
374930001587	active site
374930001588	Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat1; cd03444
374930001589	catalytic triad [active]
374930001590	dimer interface [polypeptide binding]; other site
374930001591	anaerobic ribonucleoside triphosphate reductase; Provisional; Region: PRK09263
374930001592	ATP cone domain; Region: ATP-cone; pfam03477
374930001593	Class III ribonucleotide reductase; Region: RNR_III; cd01675
374930001594	effector binding site; other site
374930001595	active site
374930001596	Zn binding site [ion binding]; other site
374930001597	glycine loop; other site
374930001598	Nucleotidyltransferase substrate binding protein like; Region: NTase_sub_bind; cl08495
374930001599	Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403
374930001600	active site
374930001601	NTP binding site [chemical binding]; other site
374930001602	metal binding triad [ion binding]; metal-binding site
374930001603	antibiotic binding site [chemical binding]; other site
374930001604	heat shock protein GrpE; Provisional; Region: PRK14140
374930001605	GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding...; Region: GrpE; cd00446
374930001606	dimer interface [polypeptide binding]; other site
374930001607	hsp70 (ATPase domain) interactions [polypeptide binding]; other site
374930001608	Diacylglycerol kinase catalytic domain; Region: DAGK_cat; cl01255
374930001609	inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK02231
374930001610	DNA repair protein RecN; Region: recN; TIGR00634
374930001611	RecN ATPase involved in DNA repair; ABC (ATP-binding cassette) transporter nucleotide-binding domain; ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds including sugars, ions, peptides...; Region: ABC_RecN; cd03241
374930001612	Walker A/P-loop; other site
374930001613	ATP binding site [chemical binding]; other site
374930001614	Q-loop/lid; other site
374930001615	RecN ATPase involved in DNA repair; ABC (ATP-binding cassette) transporter nucleotide-binding domain; ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds including sugars, ions, peptides...; Region: ABC_RecN; cd03241
374930001616	ABC transporter signature motif; other site
374930001617	Walker B; other site
374930001618	D-loop; other site
374930001619	H-loop/switch region; other site
374930001620	potential frameshift: common BLAST hit: gi|16272043|ref|NP_438242.1| glutamate-ammonia-ligase adenylyltransferase [Haemophilus]
374930001621	IPP transferase; Region: IPPT; cl00403
374930001622	DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095
374930001623	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
374930001624	ATP binding site [chemical binding]; other site
374930001625	Mg2+ binding site [ion binding]; other site
374930001626	G-X-G motif; other site
374930001627	MutL_Trans_MutL: transducer domain, having a ribosomal S5 domain 2-like fold, found in proteins similar to Escherichia coli MutL.  EcMutL belongs to the DNA mismatch repair (MutL/MLH1/PMS2) family.  This transducer domain is homologous to the second...; Region: MutL_Trans_MutL; cd03482
374930001628	ATP binding site [chemical binding]; other site
374930001629	MutL C terminal dimerisation domain; Region: MutL_C; cl07336
374930001630	N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696
374930001631	active site
374930001632	FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388
374930001633	Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cl00107
374930001634	Uncharacterised P-loop hydrolase UPF0079; Region: UPF0079; cl00520
374930001635	7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483
374930001636	catalytic center binding site [active]
374930001637	ATP binding site [chemical binding]; other site
374930001638	poly(A) polymerase; Region: pcnB; TIGR01942
374930001639	Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398
374930001640	active site
374930001641	NTP binding site [chemical binding]; other site
374930001642	metal binding triad [ion binding]; metal-binding site
374930001643	Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627
374930001644	Polymerase A arginine-rich C-terminus; Region: PolyA_pol_arg_C; pfam12626
374930001645	Prokaryotic dksA/traR C4-type zinc finger; Region: zf-dskA_traR; cl00755
374930001646	DNA internalization-related competence protein ComEC/Rec2; Region: ComEC_Rec2; TIGR00361
374930001647	Competence protein; Region: Competence; cl00471
374930001648	Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446
374930001649	lipid transporter ATP-binding/permease protein; Provisional; Region: PRK11176
374930001650	ABC transporter transmembrane region; Region: ABC_membrane; cl00549
374930001651	MsbA is an essential ABC transporter, closely related to eukaryotic MDR proteins.  ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars, ions, peptides, and more complex organic...; Region: ABCC_MsbA; cd03251
374930001652	Walker A/P-loop; other site
374930001653	ATP binding site [chemical binding]; other site
374930001654	Q-loop/lid; other site
374930001655	ABC transporter signature motif; other site
374930001656	Walker B; other site
374930001657	D-loop; other site
374930001658	H-loop/switch region; other site
374930001659	Tetraacyldisaccharide-1-P 4'-kinase; Region: LpxK; cl03652
374930001660	tetraacyldisaccharide 4'-kinase; Region: lpxK; TIGR00682
374930001661	CMP-KDO synthetase catalyzes the activation of KDO which is an essential component of the lipopolysaccharide; Region: CMP-KDO-Synthetase; cd02517
374930001662	Ligand binding site [chemical binding]; other site
374930001663	oligomer interface [polypeptide binding]; other site
374930001664	excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558
374930001665	GIY-YIG catalytic domain; Region: GIY-YIG; cl01061
374930001666	UvrB/uvrC motif; Region: UVR; pfam02151
374930001667	UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459
374930001668	Helix-hairpin-helix motif; Region: HHH_2; pfam12826
374930001669	Integral membrane protein TerC family; Region: TerC; cl10468
374930001670	mannonate dehydratase; Provisional; Region: PRK03906
374930001671	mannonate dehydratase; Region: uxuA; TIGR00695
374930001672	DNA-binding transcriptional repressor UxuR; Provisional; Region: PRK10225
374930001673	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
374930001674	DNA-binding site [nucleotide binding]; DNA binding site
374930001675	FCD domain; Region: FCD; cl11656
374930001676	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
374930001677	Alcohol dehydrogenases of the MDR family; Region: Zn_ADH7; cd08261
374930001678	putative NAD(P) binding site [chemical binding]; other site
374930001679	catalytic Zn binding site [ion binding]; other site
374930001680	structural Zn binding site [ion binding]; other site
374930001681	Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl00710
374930001682	Tripartite ATP-independent periplasmic transporters, DctQ component; Region: DctQ; cl01181
374930001683	DctM-like transporters; Region: DctM; pfam06808
374930001684	Anion permease ArsB/NhaD.  These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life.  A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl09110
374930001685	2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166
374930001686	substrate binding site [chemical binding]; other site
374930001687	ATP binding site [chemical binding]; other site
374930001688	putative D-mannonate oxidoreductase, classical (c) SDR; Region: mannonate_red_SDR_c; cd08935
374930001689	3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565
374930001690	putative NAD(P) binding site [chemical binding]; other site
374930001691	active site
374930001692	keto-hydroxyglutarate-aldolase/keto-deoxy- phosphogluconate aldolase; Provisional; Region: PRK05718
374930001693	KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452
374930001694	active site
374930001695	intersubunit interface [polypeptide binding]; other site
374930001696	catalytic residue [active]
374930001697	alkylphosphonate utilization operon protein PhnA; Region: phnA; TIGR00686
374930001698	PhnA Zinc-Ribbon; Region: PhnA_Zn_Ribbon; pfam08274
374930001699	PhnA protein; Region: PhnA; pfam03831
374930001700	Bacterial protein of unknown function (YtfJ_HI0045); Region: YtfJ_HI0045; cl01158
374930001701	BAX inhibitor (BI)-1 like protein family. Mammalian members of this family of small transmembrane proteins have been shown to have an antiapoptotic effect either by stimulating the antiapoptotic function of Bcl-2, a well characterized oncogene, or...; Region: BI-1-like; cd06181
374930001702	Predicted membrane protein [Function unknown]; Region: COG3768
374930001703	Domain of unknown function (DUF697); Region: DUF697; cl12064
374930001704	PseudoU_synth_RsuA/RluD: Pseudouridine synthase, RsuA/RluD family. This group is comprised of eukaryotic, bacterial and archeal proteins similar to eight site specific Escherichia coli pseudouridine synthases: RsuA, RluA, RluB, RluC, RluD, RluE, RluF...; Region: PseudoU_synth_RluCD_like; cd02869
374930001705	active site
374930001706	Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086
374930001707	putative phosphate binding site [ion binding]; other site
374930001708	putative catalytic site [active]
374930001709	active site
374930001710	metal binding site A [ion binding]; metal-binding site
374930001711	DNA binding site [nucleotide binding]
374930001712	putative AP binding site [nucleotide binding]; other site
374930001713	putative metal binding site B [ion binding]; other site
374930001714	TIGR01619 family protein; Region: hyp_HI0040
374930001715	Family of unknown function (DUF695); Region: DUF695; pfam05117
374930001716	Protein of unknown function (DUF1260); Region: DUF1260; cl01170
374930001717	rod shape-determining protein MreD; Region: MreD; cl01087
374930001718	potential frameshift: common BLAST hit: gi|68248589|ref|YP_247701.1| rod shape-determining protein MreC [Haemophilus influenzae]
374930001719	potential frameshift: common BLAST hit: gi|16272013|ref|NP_438211.1| rod shape-determining protein [Haemophilus influenzae Rd KW20]
374930001720	rod shape-determining protein MreB; Provisional; Region: PRK13927
374930001721	hypothetical protein; Provisional; Region: PRK10039
374930001722	Cell division protein FtsA; Region: FtsA; cl11496
374930001723	ABC-type uncharacterized transport system, permease and ATPase components [General function prediction only]; Region: COG4178
374930001724	ABC transporter transmembrane region; Region: ABC_membrane; cl00549
374930001725	Peroxisomal ATP-binding cassette transporter (Pat) is involved in the import of very long-chain fatty acids (VLCFA) into the peroxisome.  The peroxisomal membrane forms a permeability barrier for a wide variety of metabolites required for and formed...; Region: ABCD_peroxisomal_ALDP; cd03223
374930001726	putative transporter; Validated; Region: PRK03818
374930001727	Predicted Permease Membrane Region; Region: Asp-Al_Ex; cl06061
374930001728	Anion permease ArsB/NhaD.  These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life.  A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl09110
374930001729	Predicted Permease Membrane Region; Region: Asp-Al_Ex; cl06061
374930001730	Domain of unknown function DUF143; Region: DUF143; cl00519
374930001731	Predicted SPOUT methyltransferase; Region: SPOUT_MTase; cl00679
374930001732	penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423
374930001733	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
374930001734	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01039
374930001735	Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511
374930001736	rare lipoprotein A; Region: rlpA; TIGR00413
374930001737	Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; cl04011
374930001738	Sporulation related domain; Region: SPOR; cl10051
374930001739	D-alanyl-D-alanine carboxypeptidase; Provisional; Region: dacD; PRK11397
374930001740	Beta-lactamase; Region: Beta-lactamase; cl01009
374930001741	Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; pfam07943
374930001742	Protein of unknown function (DUF493); Region: DUF493; cl01102
374930001743	Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057
374930001744	lipoyl synthase; Provisional; Region: PRK05481
374930001745	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster...; Region: Radical_SAM; cl14056
374930001746	[citrate (pro-3S)-lyase] ligase; Region: cit_ly_ligase; TIGR00124
374930001747	Citrate lyase ligase; Region: Citrate_lyase_ligase; cd02169
374930001748	putative active site [active]
374930001749	(T/H)XGH motif; other site
374930001750	Malonate decarboxylase delta subunit (MdcD); Region: ACP; cl06082
374930001751	Pyruvate kinase (PK):  Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl09155
374930001752	Citrate lyase, alpha subunit (CitF); Region: CitF; pfam04223
374930001753	Apo-citrate lyase phosphoribosyl-dephospho-CoA transferase; Region: CitX; cl01498
374930001754	ATP:dephospho-CoA triphosphoribosyl transferase; Region: CitG; cl00768
374930001755	Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471
374930001756	Anion permease ArsB/NhaD.  These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life.  A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cd00625
374930001757	transmembrane helices; other site
374930001758	(dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14325
374930001759	Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919
374930001760	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster...; Region: Radical_SAM; cd01335
374930001761	FeS/SAM binding site; other site
374930001762	TRAM domain; Region: TRAM; cl01282
374930001763	Uracil DNA glycosylase superfamily; Region: UDG; cl00483
374930001764	Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939
374930001765	GTP-binding protein LepA; Provisional; Region: PRK05433
374930001766	LepA subfamily.  LepA belongs to the GTPase family of and exhibits significant homology to the translation factors EF-G and EF-Tu, indicating its possible involvement in translation and association with the ribosome.  LepA is ubiquitous in bacteria and...; Region: LepA; cd01890
374930001767	G1 box; other site
374930001768	putative GEF interaction site [polypeptide binding]; other site
374930001769	GTP/Mg2+ binding site [chemical binding]; other site
374930001770	Switch I region; other site
374930001771	G2 box; other site
374930001772	G3 box; other site
374930001773	Switch II region; other site
374930001774	G4 box; other site
374930001775	G5 box; other site
374930001776	lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-...; Region: lepA_II; cd03699
374930001777	lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane.   LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709
374930001778	GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421
374930001779	signal peptidase I; Provisional; Region: PRK10861
374930001780	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
374930001781	Catalytic site [active]
374930001782	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
374930001783	ribonuclease III; Reviewed; Region: rnc; PRK00102
374930001784	RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in post-...; Region: RIBOc; cd00593
374930001785	dimerization interface [polypeptide binding]; other site
374930001786	active site
374930001787	metal binding site [ion binding]; metal-binding site
374930001788	Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase...; Region: DSRM; cd00048
374930001789	dsRNA binding site [nucleotide binding]; other site
374930001790	potential frameshift: common BLAST hit: gi|68248564|ref|YP_247676.1| GTP-binding protein Era [Haemophilus influenzae 86-028NP]
374930001791	16S ribosomal RNA m2G1207 methyltransferase; Provisional; Region: rsmC; PRK09489
374930001792	Methyltransferase small domain N-terminal; Region: MTS_N; pfam08468
374930001793	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440
374930001794	S-adenosylmethionine binding site [chemical binding]; other site
374930001795	DNA polymerase III psi subunit; Region: DNA_III_psi; cl11436
374930001796	ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575
374930001797	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
374930001798	Coenzyme A binding pocket [chemical binding]; other site
374930001799	formate dehydrogenase accessory protein FdhE; Provisional; Region: PRK03564; cl11689
374930001800	Uncharacterized protein involved in formate dehydrogenase formation [Posttranslational modification, protein turnover, chaperones]; Region: FdhE; COG3058
374930001801	Cytochrome b (N-terminus)/b6/petB:  Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria...; Region: Cytochrome_b_N; cl00859
374930001802	Fe-S containing; Region: FDH-beta; TIGR01582
374930001803	Formate dehydrogenase N, transmembrane; Region: Form-deh_trans; pfam09163
374930001804	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and tungsten-...; Region: Molybdopterin-Binding; cl09928
374930001805	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and tungsten-...; Region: Molybdopterin-Binding; cl09928
374930001806	Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_CT_Formate-Dh-Na-like; cd02792
374930001807	molybdopterin cofactor binding site; other site
374930001808	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and tungsten-...; Region: Molybdopterin-Binding; cl09928
374930001809	FdhD/NarQ family; Region: FdhD-NarQ; cl00659
374930001810	Uncharacterized protein family UPF0054; Region: UPF0054; cl00402
374930001811	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cd01427
374930001812	haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282
374930001813	active site
374930001814	motif I; other site
374930001815	motif II; other site
374930001816	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cl11391
374930001817	Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022
374930001818	Acyl-protein synthetase, LuxE; Region: LuxE; cl10450
374930001819	Acyl-protein synthetase, LuxE; Region: LuxE; cl10450
374930001820	glyceraldehyde-3-phosphate dehydrogenase A; Provisional; Region: gapA; PRK15425
374930001821	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
374930001822	Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800
374930001823	Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and...; Region: GMPK; cd00071
374930001824	catalytic site [active]
374930001825	RNA polymerase Rpb6; Region: RNA_pol_Rpb6; cl14651
374930001826	(p)ppGpp synthetase, RelA/SpoT family; Region: spoT_relA; TIGR00691
374930001827	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076
374930001828	Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399
374930001829	synthetase active site [active]
374930001830	NTP binding site [chemical binding]; other site
374930001831	metal binding site [ion binding]; metal-binding site
374930001832	TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named...; Region: TGS_RelA_SpoT; cd01668
374930001833	ACT  domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876
374930001834	ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917
374930001835	RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a four-...; Region: RecG_wedge_OBF; cd04488
374930001836	generic binding surface II; other site
374930001837	ssDNA binding site; other site
374930001838	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
374930001839	ATP binding site [chemical binding]; other site
374930001840	putative Mg++ binding site [ion binding]; other site
374930001841	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
374930001842	nucleotide binding region [chemical binding]; other site
374930001843	ATP-binding site [chemical binding]; other site
374930001844	Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518
374930001845	L-lactate dehydrogenase; Provisional; Region: lldD; PRK11197
374930001846	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl09108
374930001847	phosphate binding site [ion binding]; other site
374930001848	DNA-binding transcriptional regulator MetR; Provisional; Region: PRK15421
374930001849	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088
374930001850	The C-terminal substrate binding domain of LysR-type transcriptional regulator metR, which regulates the expression of methionine biosynthetic genes, contains type 2 periplasmic binding fold; Region: PBP2_MetR; cd08441
374930001851	putative dimerization interface [polypeptide binding]; other site
374930001852	AzlC protein; Region: AzlC; cl00570
374930001853	Branched-chain amino acid transport protein (AzlD); Region: AzlD; cl00735
374930001854	peptide chain release factor 3; Provisional; Region: prfC; PRK00741
374930001855	RF3 subfamily.  Peptide chain release factor 3 (RF3) is a protein involved in the termination step of translation in bacteria.  Termination occurs when class I release factors (RF1 or RF2) recognize the stop codon at the A-site of the ribosome and...; Region: RF3; cd04169
374930001856	G1 box; other site
374930001857	putative GEF interaction site [polypeptide binding]; other site
374930001858	GTP/Mg2+ binding site [chemical binding]; other site
374930001859	Switch I region; other site
374930001860	G2 box; other site
374930001861	G3 box; other site
374930001862	Switch II region; other site
374930001863	G4 box; other site
374930001864	G5 box; other site
374930001865	RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689
374930001866	Enoyl-[acyl-carrier-protein]; Region: FabI; COG0623
374930001867	Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372
374930001868	NAD binding site [chemical binding]; other site
374930001869	homotetramer interface [polypeptide binding]; other site
374930001870	homodimer interface [polypeptide binding]; other site
374930001871	substrate binding site [chemical binding]; other site
374930001872	active site
374930001873	potential frameshift: common BLAST hit: gi|68250330|ref|YP_249442.1| exoribonuclease II [Haemophilus influenzae 86-028NP]
374930001874	Allophanate hydrolase subunit 1; Region: AHS1; pfam02682
374930001875	Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; cl00896
374930001876	Allophanate hydrolase subunit 2; Region: AHS2; cl00865
374930001877	Allophanate hydrolase subunit 2; Region: AHS2; pfam02626
374930001878	LamB/YcsF family; Region: LamB_YcsF; cl00664
374930001879	potential frameshift: common BLAST hit: gi|68250326|ref|YP_249438.1| Mn2+ and Fe2+ transporter of the NRAMP family [Haemophilus]
374930001880	argininosuccinate synthase; Region: argG; TIGR00032
374930001881	Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate .  In...; Region: Argininosuccinate_Synthase; cd01999
374930001882	ANP binding site [chemical binding]; other site
374930001883	Substrate Binding Site II [chemical binding]; other site
374930001884	Substrate Binding Site I [chemical binding]; other site
374930001885	non-metazoan 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_Sc; cd01414
374930001886	ATP binding site [chemical binding]; other site
374930001887	active site
374930001888	substrate binding site [chemical binding]; other site
374930001889	penicillin-binding protein 1B; Region: PBP_1b; TIGR02071
374930001890	Transglycosylase; Region: Transgly; cl07896
374930001891	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01039
374930001892	Uncharacterised protein family (UPF0231); Region: UPF0231; cl11474
374930001893	Iron-sulphur cluster biosynthesis; Region: Fe-S_biosyn; cl00400
374930001894	methionine aminopeptidase; Reviewed; Region: PRK07281
374930001895	Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086
374930001896	active site
374930001897	PII uridylyl-transferase; Provisional; Region: glnD; PRK01759
374930001898	Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401
374930001899	metal binding triad; other site
374930001900	GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335
374930001901	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076
374930001902	ACT domain family, ACT_UUR-like_1, includes the first of two C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_UUR-like_1; cd04900
374930001903	C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_ACR-UUR-like_2; cd04899
374930001904	UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472
374930001905	This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853
374930001906	Mg++ binding site [ion binding]; other site
374930001907	putative catalytic motif [active]
374930001908	substrate binding site [chemical binding]; other site
374930001909	DEDDh 3'-5' exonuclease domain of oligoribonuclease and similar proteins; Region: Orn; cd06135
374930001910	putative active site [active]
374930001911	putative substrate binding site [chemical binding]; other site
374930001912	catalytic site [active]
374930001913	dimer interface [polypeptide binding]; other site
374930001914	GTPase RsgA; Reviewed; Region: PRK12288
374930001915	YjeQ/EngC.  YjeQ (YloQ in Bacillus subtilis) represents a protein family whose members are broadly conserved in bacteria and have been shown to be essential to the growth of E. coli and B. subtilis. Proteins of the YjeQ family contain all sequence...; Region: YjeQ_engC; cd01854
374930001916	GTPase/OB domain interface [polypeptide binding]; other site
374930001917	GTPase/Zn-binding domain interface [polypeptide binding]; other site
374930001918	GTP/Mg2+ binding site [chemical binding]; other site
374930001919	G4 box; other site
374930001920	G5 box; other site
374930001921	G1 box; other site
374930001922	Switch I region; other site
374930001923	G2 box; other site
374930001924	G3 box; other site
374930001925	Switch II region; other site
374930001926	Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367
374930001927	dimerization domain swap beta strand [polypeptide binding]; other site
374930001928	regulatory protein interface [polypeptide binding]; other site
374930001929	active site
374930001930	regulatory phosphorylation site [posttranslational modification]; other site
374930001931	phosphoenolpyruvate-protein phosphotransferase; Provisional; Region: PRK11177
374930001932	PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524
374930001933	PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; cl01586
374930001934	Pyruvate kinase (PK):  Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl09155
374930001935	PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_glc; cl00162
374930001936	HPr interaction site; other site
374930001937	glycerol kinase (GK) interaction site [polypeptide binding]; other site
374930001938	active site
374930001939	phosphorylation site [posttranslational modification]
374930001940	Phosphomannose isomerase [Carbohydrate transport and metabolism]; Region: ManA; COG1482
374930001941	Bacterial OB fold (BOF) protein; Region: BOF; cl01196
374930001942	DNA-binding transcriptional regulator QseB; Provisional; Region: PRK10336
374930001943	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156
374930001944	active site
374930001945	phosphorylation site [posttranslational modification]
374930001946	intermolecular recognition site; other site
374930001947	dimerization interface [polypeptide binding]; other site
374930001948	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase...; Region: trans_reg_C; cd00383
374930001949	DNA binding site [nucleotide binding]
374930001950	sensor protein QseC; Provisional; Region: PRK10337
374930001951	Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The...; Region: HAMP; cl01054
374930001952	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082
374930001953	dimer interface [polypeptide binding]; other site
374930001954	phosphorylation site [posttranslational modification]
374930001955	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
374930001956	ATP binding site [chemical binding]; other site
374930001957	Mg2+ binding site [ion binding]; other site
374930001958	G-X-G motif; other site
374930001959	BCCT family transporter; Region: BCCT; cl00569
374930001960	choline transport protein BetT; Provisional; Region: PRK09928
374930001961	multifunctional aminopeptidase A; Provisional; Region: PRK00913
374930001962	Cytosol aminopeptidase family, N-terminal and catalytic domains.  Family M17 contains zinc- and manganese-dependent exopeptidases ( EC  3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein...; Region: Peptidase_M17; cd00433
374930001963	interface (dimer of trimers) [polypeptide binding]; other site
374930001964	Substrate-binding/catalytic site; other site
374930001965	Zn-binding sites [ion binding]; other site
374930001966	Predicted permeases [General function prediction only]; Region: COG0795; cl12074
374930001967	Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739
374930001968	Predicted permeases [General function prediction only]; Region: COG0795; cl12074
374930001969	Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739
374930001970	5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase; Provisional; Region: PRK05222
374930001971	N-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme catalyses the last step in the production of methionine by...; Region: CIMS_N_terminal_like; cd03312
374930001972	THF binding site; other site
374930001973	C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme catalyses the last step in the production of methionine by...; Region: CIMS_C_terminal_like; cd03311
374930001974	substrate binding site [chemical binding]; other site
374930001975	THF binding site; other site
374930001976	zinc-binding site [ion binding]; other site
374930001977	YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259
374930001978	putative active site [active]
374930001979	Polysaccharide biosynthesis protein; Region: Polysacc_synt; cl10513
374930001980	potential frameshift: common BLAST hit: gi|68250303|ref|YP_249415.1| CMP-N-acetylneuraminate-beta-galactosamide-alpha-2
374930001981	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
374930001982	This family is most closely related to the GT1 family of glycosyltransferases. AmSD in Erwinia amylovora has been shown to be involved in the biosynthesis of amylovoran, the acidic exopolysaccharide acting as a virulence factor. This enzyme may be...; Region: GT1_amsD_like; cd03820
374930001983	putative ADP-binding pocket [chemical binding]; other site
374930001984	Glycosyltransferase family 25 [lipooligosaccharide (LOS) biosynthesis protein] is a family of glycosyltransferases involved in LOS biosynthesis. The members include the beta(1,4) galactosyltransferases: Lgt2 of Moraxella catarrhalis, LgtB and LgtE of...; Region: Glyco_transf_25; cd06532
374930001985	Predicted glycosyltransferases [General function prediction only]; Region: COG1216
374930001986	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
374930001987	active site
374930001988	Predicted glycosyltransferases [General function prediction only]; Region: COG1216
374930001989	GT2_AmsE_like is involved in exopolysaccharide amylovora biosynthesis; Region: GT2_AmsE_like; cd04195
374930001990	DNA-binding transcriptional regulator ModE; Provisional; Region: PRK10676
374930001991	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088
374930001992	TOBE domain; Region: TOBE_2; cl01440
374930001993	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
374930001994	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261
374930001995	dimer interface [polypeptide binding]; other site
374930001996	conserved gate region; other site
374930001997	putative PBP binding loops; other site
374930001998	ABC-ATPase subunit interface; other site
374930001999	molybdate transporter ATP-binding protein; Provisional; Region: modC; PRK11144
374930002000	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099
374930002001	Walker A/P-loop; other site
374930002002	ATP binding site [chemical binding]; other site
374930002003	Q-loop/lid; other site
374930002004	ABC transporter signature motif; other site
374930002005	Walker B; other site
374930002006	D-loop; other site
374930002007	H-loop/switch region; other site
374930002008	TOBE domain; Region: TOBE_2; cl01440
374930002009	Sodium:neurotransmitter symporter family; Region: SNF; cl11976
374930002010	endonuclease III; Provisional; Region: PRK10702
374930002011	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
374930002012	minor groove reading motif; other site
374930002013	helix-hairpin-helix signature motif; other site
374930002014	substrate binding pocket [chemical binding]; other site
374930002015	active site
374930002016	FES domain; Region: FES; smart00525
374930002017	Rnf-Nqr subunit, membrane protein; Region: Rnf-Nqr; cl00597
374930002018	FMN-binding domain; Region: FMN_bind; cl01081
374930002019	RnfE family; Region: NQR2_RnfD_RnfE; cl00779
374930002020	C subunit; Region: rnfC; TIGR01945
374930002021	Respiratory-chain NADH dehydrogenase 51 Kd subunit; Region: Complex1_51K; pfam01512
374930002022	SLBB domain; Region: SLBB; pfam10531
374930002023	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved alpha-; Region: HCP_like; cl14655
374930002024	electron transport complex protein RnfB; Provisional; Region: PRK05113
374930002025	Putative Fe-S cluster; Region: FeS; pfam04060
374930002026	Rnf-Nqr subunit, membrane protein; Region: Rnf-Nqr; cl00597
374930002027	Peptidase family S49 N-terminal; Region: Peptidase_S49_N; pfam08496
374930002028	putative inner membrane peptidase; Provisional; Region: PRK11778
374930002029	Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023
374930002030	tandem repeat interface [polypeptide binding]; other site
374930002031	oligomer interface [polypeptide binding]; other site
374930002032	active site residues [active]
374930002033	Uncharacterized protein conserved in bacteria (DUF2057); Region: DUF2057; cl11437
374930002034	hypothetical membrane protein, TIGR01666; Region: YCCS
374930002035	FUSC-like inner membrane protein yccS; Region: FUSC-like; pfam12805
374930002036	Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones]; Region: Spy; COG3914
374930002037	Surface antigen; Region: Bac_surface_Ag; cl03097
374930002038	haemagglutination activity domain; Region: Haemagg_act; cl05436
374930002039	Equine herpesvirus glycoprotein gp2; Region: Herpes_gp2; pfam05955
374930002040	Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282
374930002041	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cd01427
374930002042	active site
374930002043	motif I; other site
374930002044	motif II; other site
374930002045	Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561
374930002046	KpsF/GutQ family protein; Region: kpsF; TIGR00393
374930002047	KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose 5-...; Region: SIS_Kpsf; cd05014
374930002048	putative active site [active]
374930002049	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with KpsF/GutQ domains in the API [A5P (D-arabinose 5-phosphate) isomerase] protein.  These APIs catalyze the conversion of the pentose pathway...; Region: CBS_pair_KpsF_GutQ_assoc; cd04604
374930002050	iron-sulfur cluster repair di-iron protein; Provisional; Region: PRK10992
374930002051	Domain of unknown function (DUF1858); Region: DUF1858; cl14817
374930002052	Hemerythrin (Hr) is a non-heme diiron oxygen transport protein found in four marine invertebrate phyla including priapulida, brachiopoda, sipunculida, and annelida, as well as in protozoa. Myohemerythrin (Mhr), a hemerythrin homolog, is found in the...; Region: Hemerythrin; cl11605
374930002053	Hemerythrin (Hr) is a non-heme diiron oxygen transport protein found in four marine invertebrate phyla including priapulida, brachiopoda, sipunculida, and annelida, as well as in protozoa. Myohemerythrin (Mhr), a hemerythrin homolog, is found in the...; Region: Hemerythrin; cl11605
374930002054	molybdenum cofactor biosynthesis protein A; Reviewed; Region: moaA; PRK00164
374930002055	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster...; Region: Radical_SAM; cd01335
374930002056	FeS/SAM binding site; other site
374930002057	Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463
374930002058	MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a...; Region: MoaC_PE; cd01420
374930002059	trimer interface [polypeptide binding]; other site
374930002060	dimer interface [polypeptide binding]; other site
374930002061	putative active site [active]
374930002062	Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754
374930002063	MoaE interaction surface [polypeptide binding]; other site
374930002064	MoeB interaction surface [polypeptide binding]; other site
374930002065	thiocarboxylated glycine; other site
374930002066	MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756
374930002067	MoaE homodimer interface [polypeptide binding]; other site
374930002068	MoaD interaction [polypeptide binding]; other site
374930002069	active site residues [active]
374930002070	Paraquat-inducible protein B [General function prediction only]; Region: PqiB; COG3008
374930002071	mce related protein; Region: MCE; cl03606
374930002072	Paraquat-inducible protein B [General function prediction only]; Region: PqiB; COG3008
374930002073	mce related protein; Region: MCE; cl03606
374930002074	mce related protein; Region: MCE; cl03606
374930002075	integral membrane protein, PqiA family; Region: pqiA_fam; TIGR00155
374930002076	Paraquat-inducible protein A; Region: PqiA; pfam04403
374930002077	Paraquat-inducible protein A; Region: PqiA; pfam04403
374930002078	FinO bacterial conjugation repressor domain;  the basic protein FinO is part of the the two component FinOP system which is responsible for repressing bacterial conjugation; the FinOP system represses the transfer (tra) operon of the F-plasmid which...; Region: FinO_conjug_rep; cl00174
374930002079	FinO bacterial conjugation repressor domain;  the basic protein FinO is part of the the two component FinOP system which is responsible for repressing bacterial conjugation; the FinOP system represses the transfer (tra) operon of the F-plasmid which...; Region: FinO_conjug_rep; cl00174
374930002080	carboxy-terminal protease; Provisional; Region: PRK11186
374930002081	PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988
374930002082	protein binding site [polypeptide binding]; other site
374930002083	C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560
374930002084	Catalytic dyad [active]
374930002085	C-terminal domain of tail specific protease (DUF3340); Region: DUF3340; pfam11818
374930002086	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2989
374930002087	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2989
374930002088	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
374930002089	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
374930002090	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3108
374930002091	Peptidase M15; Region: Peptidase_M15_3; cl01194
374930002092	TatD like proteins;  E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310
374930002093	active site
374930002094	Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446
374930002095	2-oxoglutarate dehydrogenase E1 component; Reviewed; Region: sucA; PRK09404
374930002096	TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of 2-oxoglutarate to succinyl-CoA and carbon dioxide, a key reaction of...; Region: TPP_E1_OGDC_like; cd02016
374930002097	TPP-binding site [chemical binding]; other site
374930002098	Pyrimidine (PYR) binding domain of thiamine pyrophosphate (TPP)-dependent enzymes; Region: TPP_enzyme_PYR; cl11410
374930002099	dihydrolipoamide succinyltransferase; Validated; Region: PRK05704
374930002100	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
374930002101	E3 interaction surface; other site
374930002102	lipoyl attachment site [posttranslational modification]; other site
374930002103	e3 binding domain; Region: E3_binding; pfam02817
374930002104	2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; cl02008
374930002105	Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049
374930002106	dimer interface [polypeptide binding]; other site
374930002107	putative radical transfer pathway; other site
374930002108	diiron center [ion binding]; other site
374930002109	tyrosyl radical; other site
374930002110	ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK09103
374930002111	ATP cone domain; Region: ATP-cone; pfam03477
374930002112	Class I ribonucleotide reductase; Region: RNR_I; cd01679
374930002113	active site
374930002114	dimer interface [polypeptide binding]; other site
374930002115	catalytic residues [active]
374930002116	effector binding site; other site
374930002117	R2 peptide binding site; other site
374930002118	BON domain; Region: BON; cl02771
374930002119	BON domain; Region: BON; cl02771
374930002120	Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006
374930002121	dimer interface [polypeptide binding]; other site
374930002122	active site
374930002123	Uncharacterised protein family UPF0102; Region: UPF0102; cl00516
374930002124	LppC putative lipoprotein; Region: LppC; pfam04348
374930002125	Periplasmic binding component of lipoprotein LppC, an immunodominant antigen; Region: PBP1_YraM_LppC_lipoprotein_like; cd06339
374930002126	putative ligand binding site [chemical binding]; other site
374930002127	Predicted methyltransferases [General function prediction only]; Region: COG0313
374930002128	Tetrapyrrole (Corrin/Porphyrin) Methylases; Region: TP_methylase; cl00304
374930002129	Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; cl00398
374930002130	Putative modulator of DNA gyrase; Region: PmbA_TldD; pfam01523
374930002131	outer membrane lipoprotein; Provisional; Region: spr; PRK10838
374930002132	NlpC/P60 family; Region: NLPC_P60; cl11438
374930002133	Integrase core domain; Region: rve; cl01316
374930002134	aerobic respiration control sensor protein ArcB; Provisional; Region: PRK11091
374930002135	D-lactate dehydrogenase; Provisional; Region: PRK11183
374930002136	FAD binding domain; Region: FAD_binding_4; pfam01565
374930002137	D-lactate dehydrogenase, membrane binding; Region: Lact-deh-memb; pfam09330
374930002138	Glutamine Amidotransferase (GATase_I) involved in pyridoxine biosynthesis; Region: GATase1_PB; cd01749
374930002139	predicted active site [active]
374930002140	catalytic triad [active]
374930002141	pyridoxal biosynthesis lyase PdxS; Provisional; Region: PRK04180
374930002142	PdxS is a subunit of the pyridoxal 5'-phosphate (PLP) synthase, an important enzyme in deoxyxylulose 5-phosphate (DXP)-independent pathway for de novo biosynthesis of PLP,  present in some eubacteria, in archaea, fungi, plants, plasmodia, and some...; Region: pdxS; cd04727
374930002143	active site
374930002144	multimer interface [polypeptide binding]; other site
374930002145	cytidylate kinase; Provisional; Region: cmk; PRK00023
374930002146	Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020
374930002147	CMP-binding site; other site
374930002148	The sites determining sugar specificity; other site
374930002149	potential frameshift: common BLAST hit: gi|16273139|ref|NP_439376.1| 30S ribosomal protein S1 [Haemophilus influenzae Rd KW20]
374930002150	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and higher-...; Region: HU_IHF; cd00591
374930002151	IHF dimer interface [polypeptide binding]; other site
374930002152	IHF - DNA interface [nucleotide binding]; other site
374930002153	Protein of unknown function (DUF1049); Region: DUF1049; cl01539
374930002154	tetratricopeptide repeat protein; Provisional; Region: PRK11788
374930002155	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189
374930002156	binding surface
374930002157	TPR motif; other site
374930002158	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099
374930002159	Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase contains two...; Region: OMP_decarboxylase_like; cd04725
374930002160	active site
374930002161	dimer interface [polypeptide binding]; other site
374930002162	translation initiation factor Sui1; Validated; Region: PRK06824
374930002163	The SUI1/eIF1 (eukaryotic initiation factor 1) fold is found in eukaryotes, archaea, and some bacteria and is thought to play an important role in accurate initiator codon recognition during translation initiation. This fold, which includes two...; Region: SUI1_eIF1; cd00474
374930002164	Predicted RNA interaction site [nucleotide binding]; other site
374930002165	putative binding site; other site
374930002166	Mutations affecting start-site selection; other site
374930002167	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099
374930002168	Sulfate transporter family; Region: Sulfate_transp; cl00967
374930002169	Permease family; Region: Xan_ur_permease; pfam00860
374930002170	Phosphoribosyl transferase domain; Region: Pribosyltran; cl00309
374930002171	DNA polymerase III subunits gamma and tau; Validated; Region: PRK07994
374930002172	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009
374930002173	Walker A motif; other site
374930002174	ATP binding site [chemical binding]; other site
374930002175	Walker B motif; other site
374930002176	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099
374930002177	arginine finger; other site
374930002178	DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169
374930002179	DNA polymerase III tau subunit V interacting with alpha; Region: DNA_pol3_tau_5; pfam12170
374930002180	Phosphoribosyl transferase domain; Region: Pribosyltran; cl00309
374930002181	dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06467
374930002182	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644
374930002183	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644
374930002184	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
374930002185	dihydrolipoamide acetyltransferase; Reviewed; Region: PRK11855
374930002186	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
374930002187	E3 interaction surface; other site
374930002188	lipoyl attachment site [posttranslational modification]; other site
374930002189	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
374930002190	E3 interaction surface; other site
374930002191	lipoyl attachment site [posttranslational modification]; other site
374930002192	e3 binding domain; Region: E3_binding; pfam02817
374930002193	2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; cl02008
374930002194	pyruvate dehydrogenase subunit E1; Reviewed; Region: aceE; PRK09405
374930002195	Thiamine pyrophosphate (TPP) family, E1 of E. coli PDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the Escherichia coli pyruvate dehydrogenase multienzyme complex (PDC). PDC catalyzes the oxidative...; Region: TPP_E1_EcPDC_like; cd02017
374930002196	dimer interface [polypeptide binding]; other site
374930002197	TPP-binding site [chemical binding]; other site
374930002198	Pyrimidine (PYR) binding domain of thiamine pyrophosphate (TPP)-dependent enzymes; Region: TPP_enzyme_PYR; cl11410
374930002199	Methylglyoxal synthase catalyzes the enolization of dihydroxyacetone phosphate (DHAP) to produce methylglyoxal. The first part of the catalytic mechanism is believed to be similar to TIM (triosephosphate isomerase) in that both enzymes utilize DHAP to...; Region: MGS; cd01422
374930002200	active site
374930002201	dimer interfaces [polypeptide binding]; other site
374930002202	catalytic residues [active]
374930002203	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5339
374930002204	hypothetical protein; Provisional; Region: PRK11367
374930002205	molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290
374930002206	potential frameshift: common BLAST hit: gi|16273157|ref|NP_439394.1| heat shock protein [Haemophilus influenzae Rd KW20]
374930002207	Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079
374930002208	gamma-glutamyl phosphate reductase; Region: proA; TIGR00407
374930002209	putative catalytic cysteine [active]
374930002210	Predicted membrane protein [Function unknown]; Region: COG2860
374930002211	UPF0126 domain; Region: UPF0126; pfam03458
374930002212	UPF0126 domain; Region: UPF0126; pfam03458
374930002213	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
374930002214	putative substrate translocation pore; other site
374930002215	drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710
374930002216	16S rRNA pseudouridylate synthase A; Provisional; Region: PRK10839
374930002217	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
374930002218	RNA binding surface [nucleotide binding]; other site
374930002219	PseudoU_synth_RsuA: Pseudouridine synthase, Escherichia coli RsuA like. This group is comprised of eukaryotic and bacterial proteins similar to Escherichia coli RsuA. Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA...; Region: PseudoU_synth_RsuA; cd02553
374930002220	active site
374930002221	uracil binding [chemical binding]; other site
374930002222	Domain of unknown function (DUF1919); Region: DUF1919; cl01628
374930002223	bifunctional malic enzyme oxidoreductase/phosphotransacetylase; Reviewed; Region: PRK07232
374930002224	Malic enzyme, N-terminal domain; Region: malic; pfam00390
374930002225	NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311
374930002226	putative NAD(P) binding site [chemical binding]; other site
374930002227	Phosphate acetyl/butaryl transferase; Region: PTA_PTB; cl00390
374930002228	potential frameshift: common BLAST hit: gi|68250222|ref|YP_249334.1| predicted phosphoglycerol transferase-like protein [Haemophilus]
374930002229	potential frameshift: common BLAST hit: gi|68250221|ref|YP_249333.1| excinuclease ABC subunit B [Haemophilus influenzae 86-028NP]
374930002230	High-affinity nickel-transport protein; Region: NicO; cl00964
374930002231	Protein of unknown function (DUF1007); Region: DUF1007; cl01487
374930002232	Plasmid maintenance system killer protein; Region: Plasmid_killer; cl01422
374930002233	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl09100
374930002234	putative ABC transporter ATP-binding protein; Reviewed; Region: PRK11819
374930002235	ABCF_EF-3  Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth.  EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by...; Region: ABCF_EF-3; cd03221
374930002236	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099
374930002237	ABCF_EF-3  Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth.  EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by...; Region: ABCF_EF-3; cd03221
374930002238	ABC transporter; Region: ABC_tran_2; pfam12848
374930002239	ABCF_EF-3  Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth.  EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by...; Region: ABCF_EF-3; cd03221
374930002240	Invasion gene expression up-regulator, SirB; Region: SirB; cl01184
374930002241	Predicted P-loop ATPase fused to an acetyltransferase [General function prediction only]; Region: COG1444
374930002242	Domain of unknown function (DUF1726); Region: DUF1726; pfam08351
374930002243	Putative ATPase (DUF699); Region: DUF699; pfam05127
374930002244	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357
374930002245	transcription-repair coupling factor; Provisional; Region: PRK10689
374930002246	CarD-like/TRCF domain; Region: CarD_TRCF; cl00588
374930002247	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
374930002248	ATP binding site [chemical binding]; other site
374930002249	putative Mg++ binding site [ion binding]; other site
374930002250	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
374930002251	nucleotide binding region [chemical binding]; other site
374930002252	ATP-binding site [chemical binding]; other site
374930002253	TRCF domain; Region: TRCF; pfam03461
374930002254	periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037
374930002255	Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic...; Region: Tryp_SPc; cl00149
374930002256	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind C-...; Region: PDZ_serine_protease; cd00987
374930002257	protein binding site [polypeptide binding]; other site
374930002258	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind C-...; Region: PDZ_serine_protease; cd00987
374930002259	acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654
374930002260	Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl00513
374930002261	potential frameshift: common BLAST hit: gi|68250209|ref|YP_249321.1| folylpolyglutamate synthase [Haemophilus influenzae 86-028NP]
374930002262	YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259
374930002263	putative active site [active]
374930002264	Homoserine acetyltransferase [Amino acid transport and metabolism]; Region: MET2; COG2021
374930002265	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
374930002266	DNA gyrase subunit A; Validated; Region: PRK05560
374930002267	DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes in...; Region: TOP4c; cd00187
374930002268	CAP-like domain; other site
374930002269	Active site [active]
374930002270	primary dimer interface [polypeptide binding]; other site
374930002271	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
374930002272	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
374930002273	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
374930002274	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
374930002275	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
374930002276	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
374930002277	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440
374930002278	SAM-dependent methyltransferases [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: SmtA; COG0500
374930002279	S-adenosylmethionine binding site [chemical binding]; other site
374930002280	potential frameshift: common BLAST hit: gi|16273189|ref|NP_439427.1| hydroxyacylglutathione hydrolase [Haemophilus influenzae Rd KW20]
374930002281	tellurite resistance protein TehB; Provisional; Region: PRK12335
374930002282	Domain of unknown function (DUF1971); Region: DUF1971; cl01451
374930002283	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011
374930002284	methionyl-tRNA synthetase; Reviewed; Region: metG; PRK00133
374930002285	catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814
374930002286	active site
374930002287	HIGH motif; other site
374930002288	KMSKS motif; other site
374930002289	Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957
374930002290	tRNA binding surface [nucleotide binding]; other site
374930002291	anticodon binding site; other site
374930002292	tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins.  This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties.  MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800
374930002293	dimer interface [polypeptide binding]; other site
374930002294	putative tRNA-binding site [nucleotide binding]; other site
374930002295	antiporter inner membrane protein; Provisional; Region: PRK11670
374930002296	MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037
374930002297	NAD(P)H:FMN oxidoreductase family. This domain catalyzes the reduction of flavin, nitrocompound, quinones and azo compounds using NADH or NADPH as an electron donor. The enzyme is a homodimer, and each monomer binds a FMN as co-factor. This family...; Region: NfsB_like_nitroreductase; cd02149
374930002298	dimer interface [polypeptide binding]; other site
374930002299	FMN binding site [chemical binding]; other site
374930002300	CMP-NeuAc_Synthase activates N-acetylneuraminic acid by adding CMP moiety; Region: CMP-NeuAc_Synthase; cd02513
374930002301	ligand binding site [chemical binding]; other site
374930002302	tetramer interface [polypeptide binding]; other site
374930002303	Integrase core domain; Region: rve; cl01316
374930002304	ribosome maturation protein RimP; Reviewed; Region: PRK00092
374930002305	The eukaryotic Sm and Sm-like (LSm) proteins associate with RNA to form the core domain of the ribonucleoprotein particles involved in a variety of RNA processing events including pre-mRNA splicing, telomere replication, and mRNA degradation.  Members...; Region: Sm_like; cl00259
374930002306	The eukaryotic Sm and Sm-like (LSm) proteins associate with RNA to form the core domain of the ribonucleoprotein particles involved in a variety of RNA processing events including pre-mRNA splicing, telomere replication, and mRNA degradation.  Members...; Region: Sm_like; cl00259
374930002307	Sm1 motif; other site
374930002308	D3 - B interaction site; other site
374930002309	D1 - D2 interaction site; other site
374930002310	Hfq - Hfq interaction site; other site
374930002311	RNA binding pocket [nucleotide binding]; other site
374930002312	Sm2 motif; other site
374930002313	transcription elongation factor NusA; Validated; Region: nusA; PRK09202
374930002314	NusA N-terminal domain; Region: NusA_N; pfam08529
374930002315	S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and...; Region: S1_NusA; cd04455
374930002316	RNA binding site [nucleotide binding]; other site
374930002317	homodimer interface [polypeptide binding]; other site
374930002318	NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134
374930002319	G-X-X-G motif; other site
374930002320	transcription termination factor NusA, C-terminal duplication; Region: nusA_Cterm_rpt; TIGR01954
374930002321	transcription termination factor NusA, C-terminal duplication; Region: nusA_Cterm_rpt; TIGR01954
374930002322	translation initiation factor IF-2; Region: IF-2; TIGR00487
374930002323	Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760
374930002324	IF2/eIF5B (initiation factors 2/ eukaryotic initiation factor 5B) subfamily.  IF2/eIF5B contribute to ribosomal subunit joining and function as GTPases that are maximally activated by the presence of both ribosomal subunits.  As seen in other GTPases...; Region: IF2_eIF5B; cd01887
374930002325	G1 box; other site
374930002326	putative GEF interaction site [polypeptide binding]; other site
374930002327	GTP/Mg2+ binding site [chemical binding]; other site
374930002328	Switch I region; other site
374930002329	G2 box; other site
374930002330	G3 box; other site
374930002331	Switch II region; other site
374930002332	G4 box; other site
374930002333	G5 box; other site
374930002334	This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the...; Region: IF2_mtIF2_II; cd03702
374930002335	Translation-initiation factor 2; Region: IF-2; pfam11987
374930002336	mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation...; Region: mtIF2_IVc; cd03692
374930002337	type I site-specific deoxyribonuclease, HsdR family; Region: hsdR; TIGR00348
374930002338	Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313
374930002339	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
374930002340	ATP binding site [chemical binding]; other site
374930002341	putative Mg++ binding site [ion binding]; other site
374930002342	Domain of unknown function (DUF3387); Region: DUF3387; pfam11867
374930002343	SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+...; Region: SIR2; cl00195
374930002344	Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420
374930002345	Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732
374930002346	Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420
374930002347	N-6 DNA Methylase; Region: N6_Mtase; pfam02384
374930002348	Ribosome-binding factor A; Region: RBFA; cl00542
374930002349	tRNA pseudouridine synthase B; Provisional; Region: truB; PRK05033
374930002350	PseudoU_synth_EcTruB: Pseudouridine synthase, Escherichia coli TruB like. This group consists of bacterial pseudouridine synthases similar to E. coli TruB and Mycobacterium tuberculosis TruB. Pseudouridine synthases catalyze the isomerization of...; Region: PseudoU_synth_EcTruB; cd02573
374930002351	RNA binding site [nucleotide binding]; other site
374930002352	active site
374930002353	bifunctional chorismate mutase/prephenate dehydrogenase; Provisional; Region: tyrA; PRK11199
374930002354	Chorismate mutase type II; Region: CM_2; cl00693
374930002355	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
374930002356	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2904
374930002357	7-cyano-7-deazaguanine reductase; Provisional; Region: queF; PRK11792
374930002358	Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1),  6-pyrovoyl...; Region: TFold; cl00263
374930002359	Zn-ribbon-containing, possibly nucleic-acid-binding protein (DUF2310); Region: DUF2310; cl02380
374930002360	Fe-S metabolism associated domain; Region: SufE; cl00951
374930002361	Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520
374930002362	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
374930002363	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
374930002364	catalytic residue [active]
374930002365	Staphylococcal nuclease homologues; Region: SNc; smart00318
374930002366	Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cd00175
374930002367	Catalytic site; other site
374930002368	LrgA family; Region: LrgA; cl00608
374930002369	LrgB-like family; Region: LrgB; cl00596
374930002370	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076
374930002371	deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional; Region: PRK01096
374930002372	ABC transporter ATPase component; Reviewed; Region: PRK11147
374930002373	ABCF_EF-3  Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth.  EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by...; Region: ABCF_EF-3; cd03221
374930002374	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099
374930002375	ABCF_EF-3  Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth.  EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by...; Region: ABCF_EF-3; cd03221
374930002376	ABC transporter; Region: ABC_tran_2; pfam12848
374930002377	ABCF_EF-3  Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth.  EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by...; Region: ABCF_EF-3; cd03221
374930002378	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
374930002379	Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687
374930002380	ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177
374930002381	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261
374930002382	dimer interface [polypeptide binding]; other site
374930002383	conserved gate region; other site
374930002384	ABC-ATPase subunit interface; other site
374930002385	ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177
374930002386	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261
374930002387	dimer interface [polypeptide binding]; other site
374930002388	conserved gate region; other site
374930002389	putative PBP binding loops; other site
374930002390	ABC-ATPase subunit interface; other site
374930002391	putrescine/spermidine ABC transporter ATPase protein; Reviewed; Region: potA; PRK09452
374930002392	PotA is an ABC-type transporter and the ATPase component of the spermidine/putrescine-preferential uptake system consisting of PotA, -B, -C, and -D.  PotA has two domains with the N-terminal domain containing the ATPase activity and the residues...; Region: ABC_PotA_N; cd03300
374930002393	Walker A/P-loop; other site
374930002394	ATP binding site [chemical binding]; other site
374930002395	Q-loop/lid; other site
374930002396	ABC transporter signature motif; other site
374930002397	Walker B; other site
374930002398	D-loop; other site
374930002399	H-loop/switch region; other site
374930002400	TOBE domain; Region: TOBE_2; cl01440
374930002401	peptidase T; Region: peptidase-T; TIGR01882
374930002402	M20 Peptidase T specifically cleaves tripeptides; Region: M20_peptT; cd03892
374930002403	metal binding site [ion binding]; metal-binding site
374930002404	dimer interface [polypeptide binding]; other site
374930002405	Ferritin-like domain; Region: Ferritin; pfam00210
374930002406	DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043
374930002407	dimerization interface [polypeptide binding]; other site
374930002408	DPS ferroxidase diiron center [ion binding]; other site
374930002409	ion pore; other site
374930002410	cytidine deaminase; Provisional; Region: PRK09027
374930002411	Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283
374930002412	active site
374930002413	catalytic motif [active]
374930002414	Zn binding site [ion binding]; other site
374930002415	Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283
374930002416	active site
374930002417	catalytic motif [active]
374930002418	Zn binding site [ion binding]; other site
374930002419	tRNA mo(5)U34 methyltransferase; Provisional; Region: PRK15068
374930002420	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440
374930002421	S-adenosylmethionine binding site [chemical binding]; other site
374930002422	Sodium:solute symporter family; Region: SSF; cl00456
374930002423	Predicted symporter [General function prediction only]; Region: DhlC; COG4147
374930002424	ribonuclease G; Provisional; Region: PRK11712
374930002425	S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453
374930002426	homodimer interface [polypeptide binding]; other site
374930002427	oligonucleotide binding site [chemical binding]; other site
374930002428	glutaminyl-tRNA synthetase; Provisional; Region: PRK05347
374930002429	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
374930002430	active site
374930002431	HIGH motif; other site
374930002432	nucleotide binding site [chemical binding]; other site
374930002433	catalytic core domain of glutaminyl-tRNA synthetase; Region: GlnRS_core; cd00807
374930002434	KMSKS motif; other site
374930002435	tRNA synthetases class I (E and Q), anti-codon binding domain; Region: tRNA-synt_1c_C; pfam03950
374930002436	Flagellin N-methylase; Region: FliB; cl00497
374930002437	4-alpha-glucanotransferase; Provisional; Region: malQ; PRK11052
374930002438	4-alpha-glucanotransferase; Region: Glyco_hydro_77; cl00711
374930002439	potential frameshift: common BLAST hit: gi|16273267|ref|NP_439508.1| glycogen branching enzyme [Haemophilus influenzae Rd KW20]
374930002440	glycogen debranching enzyme GlgX; Region: glgX_debranch; TIGR02100
374930002441	E or 'early' set of sugar utilizing enzymes which may be related to the immunoglobulin and/or fibronectin type III superfamilies.  These domains are associated with different types of catalytic domains at  either the N-terminal or C-terminal end; Region: E_set; cl09101
374930002442	Alpha amylase, catalytic domain; Region: Alpha-amylase; cl07893
374930002443	The enzymes of glycosyl hydrolase family 31 (GH31) occur in prokaryotes, eukaryotes, and archaea with a wide range of hydrolytic activities, including alpha-glucosidase (glucoamylase and sucrase-isomaltase), alpha-xylosidase, 6-alpha-...; Region: GH31; cl11402
374930002444	catalytic site [active]
374930002445	glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK00725
374930002446	ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508
374930002447	ligand binding site [chemical binding]; other site
374930002448	oligomer interface [polypeptide binding]; other site
374930002449	Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and rate-...; Region: LbH_G1P_AT_C; cd04651
374930002450	dimer interface [polypeptide binding]; other site
374930002451	N-terminal domain interface [polypeptide binding]; other site
374930002452	sulfate 1 binding site; other site
374930002453	glycogen synthase; Provisional; Region: glgA; PRK00654
374930002454	This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791
374930002455	ADP-binding pocket [chemical binding]; other site
374930002456	homodimer interface [polypeptide binding]; other site
374930002457	glycogen phosphorylase; Provisional; Region: PRK14986
374930002458	This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300
374930002459	homodimer interface [polypeptide binding]; other site
374930002460	active site pocket [active]
374930002461	NAD(P) transhydrogenase subunit alpha; Provisional; Region: pntA; PRK09424
374930002462	Alanine dehydrogenase/PNT, N-terminal domain; Region: AlaDh_PNT_N; pfam05222
374930002463	Domain of unknown function (DUF3814); Region: DUF3814; pfam12769
374930002464	potential frameshift: common BLAST hit: gi|68250122|ref|YP_249234.1| pyridine nucleotide transhydrogenase [Haemophilus influenzae]
374930002465	LysR family transcriptional regulator; Provisional; Region: PRK14997
374930002466	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088
374930002467	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
374930002468	putative effector binding pocket; other site
374930002469	dimerization interface [polypeptide binding]; other site
374930002470	DNA topoisomerase I subunit omega; Validated; Region: PRK07561
374930002471	TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I.   Type IA DNA topoisomerases remove (relax) negative supercoils in...; Region: TOPRIM_TopoIA_TopoI; cd03363
374930002472	active site
374930002473	interdomain interaction site; other site
374930002474	putative metal-binding site [ion binding]; other site
374930002475	nucleotide binding site [chemical binding]; other site
374930002476	DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded...; Region: TOP1Ac; cd00186
374930002477	domain I; other site
374930002478	DNA binding groove [nucleotide binding]
374930002479	phosphate binding site [ion binding]; other site
374930002480	domain II; other site
374930002481	domain III; other site
374930002482	nucleotide binding site [chemical binding]; other site
374930002483	catalytic site [active]
374930002484	domain IV; other site
374930002485	Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; cl11977
374930002486	Topoisomerase I zinc-ribbon-like; Region: Topo_Zn_Ribbon; pfam08272
374930002487	Topoisomerase I zinc-ribbon-like; Region: Topo_Zn_Ribbon; pfam08272
374930002488	NADPH-dependent FMN reductase; Region: FMN_red; cl00438
374930002489	threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413
374930002490	TGS _ThrRS_N:  ThrRS (threonyl-tRNA Synthetase)  is a class II tRNA synthetase that couples threonine to its cognate tRNA.  In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase...; Region: TGS_ThrRS_N; cd01667
374930002491	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; cl08469
374930002492	Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771
374930002493	active site
374930002494	dimer interface [polypeptide binding]; other site
374930002495	motif 1; other site
374930002496	motif 2; other site
374930002497	motif 3; other site
374930002498	ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860
374930002499	anticodon binding site; other site
374930002500	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
374930002501	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
374930002502	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
374930002503	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
374930002504	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
374930002505	potential frameshift: common BLAST hit: gi|123440706|ref|YP_001004698.1| putative exported iron receptor protein [Yersinia enterocolitica]
374930002506	TOBE domain; Region: TOBE_2; cl01440
374930002507	DsrC like protein; Region: DsrC; cl01101
374930002508	tRNA 2-thiocytidine biosynthesis protein TtcA; Provisional; Region: PRK10696
374930002509	This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily  includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which  binds to Adenosine group.  This...; Region: Alpha_ANH_like_II; cd01993
374930002510	Ligand Binding Site [chemical binding]; other site
374930002511	KicB killing factor; Region: KicB; cl11468
374930002512	MukE-like family; Region: MukE; cl11471
374930002513	potential frameshift: common BLAST hit: gi|68250109|ref|YP_249221.1| condesin subunit B [Haemophilus influenzae 86-028NP]
374930002514	Uncharacterized conserved protein [Function unknown]; Region: COG3586
374930002515	exonuclease I; Provisional; Region: sbcB; PRK11779
374930002516	N-terminal DEDDh 3'-5' exonuclease domain of Escherichia coli exonuclease I and similar proteins; Region: ExoI_N; cd06138
374930002517	active site
374930002518	substrate binding site [chemical binding]; other site
374930002519	catalytic site [active]
374930002520	Exonuclease C-terminal; Region: Exonuc_X-T_C; pfam08411
374930002521	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
374930002522	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459
374930002523	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082
374930002524	dimer interface [polypeptide binding]; other site
374930002525	phosphorylation site [posttranslational modification]
374930002526	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
374930002527	ATP binding site [chemical binding]; other site
374930002528	Mg2+ binding site [ion binding]; other site
374930002529	G-X-G motif; other site
374930002530	phosphate regulon transcriptional regulatory protein PhoB; Region: PhoB; TIGR02154
374930002531	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156
374930002532	active site
374930002533	phosphorylation site [posttranslational modification]
374930002534	intermolecular recognition site; other site
374930002535	dimerization interface [polypeptide binding]; other site
374930002536	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase...; Region: trans_reg_C; cd00383
374930002537	DNA binding site [nucleotide binding]
374930002538	phosphate transporter ATP-binding protein; Provisional; Region: pstB; PRK10744
374930002539	Phosphate uptake is of fundamental importance in the cell physiology of bacteria because phosphate is required as a nutrient.  The Pst system of E. coli comprises four distinct subunits encoded by the pstS, pstA, pstB, and pstC genes.  The PstS protein...; Region: ABC_PstB_phosphate_transporter; cd03260
374930002540	Walker A/P-loop; other site
374930002541	ATP binding site [chemical binding]; other site
374930002542	Q-loop/lid; other site
374930002543	ABC transporter signature motif; other site
374930002544	Walker B; other site
374930002545	D-loop; other site
374930002546	H-loop/switch region; other site
374930002547	phosphate transporter permease subunit PtsA; Provisional; Region: pstA; PRK11268
374930002548	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261
374930002549	dimer interface [polypeptide binding]; other site
374930002550	conserved gate region; other site
374930002551	putative PBP binding loops; other site
374930002552	ABC-ATPase subunit interface; other site
374930002553	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261
374930002554	dimer interface [polypeptide binding]; other site
374930002555	conserved gate region; other site
374930002556	putative PBP binding loops; other site
374930002557	ABC-ATPase subunit interface; other site
374930002558	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
374930002559	nonheme-containing ferritins; Region: Nonheme_Ferritin; cd01055
374930002560	Ferritin-like domain; Region: Ferritin; pfam00210
374930002561	ferroxidase diiron center [ion binding]; other site
374930002562	nonheme-containing ferritins; Region: Nonheme_Ferritin; cd01055
374930002563	Ferritin-like domain; Region: Ferritin; pfam00210
374930002564	ferroxidase diiron center [ion binding]; other site
374930002565	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
374930002566	anthranilate synthase component I; Provisional; Region: PRK13564
374930002567	Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715
374930002568	chorismate binding enzyme; Region: Chorismate_bind; cl10555
374930002569	Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743
374930002570	Glutamine amidotransferase class-I; Region: GATase; pfam00117
374930002571	glutamine binding [chemical binding]; other site
374930002572	catalytic triad [active]
374930002573	potential frameshift: common BLAST hit: gi|120554009|ref|YP_958360.1| transglutaminase-like [Marinobacter aquaeolei VT8]
374930002574	anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188
374930002575	Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885
374930002576	Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591
374930002577	bifunctional indole-3-glycerol phosphate synthase/phosphoribosylanthranilate isomerase; Provisional; Region: PRK09427
374930002578	Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331
374930002579	active site
374930002580	ribulose/triose binding site [chemical binding]; other site
374930002581	phosphate binding site [ion binding]; other site
374930002582	substrate (anthranilate) binding pocket [chemical binding]; other site
374930002583	product (indole) binding pocket [chemical binding]; other site
374930002584	Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are monomeric...; Region: PRAI; cd00405
374930002585	active site
374930002586	HupF/HypC family; Region: HupF_HypC; cl00394
374930002587	valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729
374930002588	catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817
374930002589	HIGH motif; other site
374930002590	catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817
374930002591	active site
374930002592	KMSKS motif; other site
374930002593	Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962
374930002594	tRNA binding surface [nucleotide binding]; other site
374930002595	anticodon binding site; other site
374930002596	Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458
374930002597	Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239
374930002598	putative active site [active]
374930002599	catalytic site [active]
374930002600	ASC-1 homology domain, subfamily similar to Escherichia coli Yqfb. The ASCH domain, a small beta-barrel domain found in all three kingdoms of life, resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to function...; Region: ASCH_yqfb_like; cd06552
374930002601	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099
374930002602	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099
374930002603	DNA polymerase III chi subunit, HolC; Region: DNA_pol3_chi; cl01106
374930002604	aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK06901
374930002605	A4GalT_like proteins catalyze the addition of galactose or glucose residues to the lipooligosaccharide (LOS) or lipopolysaccharide (LPS) of the bacterial cell surface; Region: GT8_A4GalT_like; cd04194
374930002606	Ligand binding site [chemical binding]; other site
374930002607	metal binding site [ion binding]; metal-binding site
374930002608	fumarate hydratase; Reviewed; Region: fumC; PRK00485
374930002609	Class II fumarases; Region: Fumarase_classII; cd01362
374930002610	active site
374930002611	tetramer interface [polypeptide binding]; other site
374930002612	Predicted metal-dependent phosphoesterases (PHP family) [General function prediction only]; Region: COG0613
374930002613	DNA polymerase alpha chain like domain; Region: POLIIIAc; smart00481
374930002614	Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD...; Region: DHOD_2_like; cd04738
374930002615	quinone interaction residues [chemical binding]; other site
374930002616	Dihydroorotate dehydrogenase [Nucleotide transport and metabolism]; Region: PyrD; COG0167
374930002617	active site
374930002618	catalytic residues [active]
374930002619	FMN binding site [chemical binding]; other site
374930002620	substrate binding site [chemical binding]; other site
374930002621	Uncharacterised protein family (UPF0150); Region: UPF0150; cl00691
374930002622	Predicted transcriptional regulators containing the CopG/Arc/MetJ DNA-binding domain and a metal-binding domain [Transcription]; Region: NikR; COG0864
374930002623	YcfA-like protein; Region: YcfA; cl00752
374930002624	Phage regulatory protein Rha (Phage_pRha); Region: Phage_pRha; cl10713
374930002625	Phage antirepressor protein KilAC domain; Region: ANT; cl01462
374930002626	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
374930002627	non-specific DNA binding site [nucleotide binding]; other site
374930002628	salt bridge; other site
374930002629	sequence-specific DNA binding site [nucleotide binding]; other site
374930002630	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
374930002631	non-specific DNA binding site [nucleotide binding]; other site
374930002632	salt bridge; other site
374930002633	sequence-specific DNA binding site [nucleotide binding]; other site
374930002634	Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (...; Region: S24_LexA-like; cd06529
374930002635	Catalytic site [active]
374930002636	Domain of unknown function (DUF1508); Region: DUF1508; cl01356
374930002637	AntA/AntB antirepressor; Region: AntA; cl01430
374930002638	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
374930002639	DNA binding site [nucleotide binding]
374930002640	Int/Topo IB signature motif; other site
374930002641	active site
374930002642	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
374930002643	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
374930002644	fumarate/nitrate reduction transcriptional regulator; Provisional; Region: PRK11161
374930002645	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
374930002646	ligand binding site [chemical binding]; other site
374930002647	flexible hinge region; other site
374930002648	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092
374930002649	putative switch regulator; other site
374930002650	non-specific DNA interactions [nucleotide binding]; other site
374930002651	DNA binding site [nucleotide binding]
374930002652	sequence specific DNA binding site [nucleotide binding]; other site
374930002653	putative cAMP binding site [chemical binding]; other site
374930002654	universal stress protein UspE; Provisional; Region: PRK11175
374930002655	universal stress protein UspE; Provisional; Region: PRK11175
374930002656	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
374930002657	Ligand Binding Site [chemical binding]; other site
374930002658	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
374930002659	Ligand Binding Site [chemical binding]; other site
374930002660	ABC-type Co2+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: CbiK; COG5266
374930002661	Nickel uptake substrate-specific transmembrane region; Region: NikM; pfam10670
374930002662	phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647
374930002663	Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645
374930002664	active site
374930002665	substrate binding site [chemical binding]; other site
374930002666	cosubstrate binding site; other site
374930002667	catalytic site [active]
374930002668	phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385
374930002669	PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine...; Region: PurM; cd02196
374930002670	dimerization interface [polypeptide binding]; other site
374930002671	putative ATP binding site [chemical binding]; other site
374930002672	potential frameshift: common BLAST hit: gi|16273335|ref|NP_439579.1| short chain dehydrogenase/reductase [Haemophilus influenzae Rd]
374930002673	tryptophan synthase, beta chain; Region: PLN02618
374930002674	Tryptophan synthase-beta:  Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446
374930002675	pyridoxal 5'-phosphate binding site [chemical binding]; other site
374930002676	catalytic residue [active]
374930002677	tryptophan synthase; Region: PLN02591
374930002678	Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are...; Region: Tryptophan_synthase_alpha; cd04724
374930002679	substrate binding site [chemical binding]; other site
374930002680	active site
374930002681	catalytic residues [active]
374930002682	heterodimer interface [polypeptide binding]; other site
374930002683	aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK06901
374930002684	This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS); Region: YbaK_deacylase; cd00002
374930002685	putative deacylase active site [active]
374930002686	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box protein...; Region: CSP_CDS; cd04458
374930002687	DNA-binding site [nucleotide binding]; DNA binding site
374930002688	RNA-binding motif; other site
374930002689	Uncharacterised protein family (UPF0181); Region: UPF0181; cl11477
374930002690	tRNA pseudouridine isomerase C: Pseudouridine synthases catalyze the isomerization of specific uridines in an tRNA molecule to pseudouridines (5-ribosyluracil, psi).  No cofactors are required. TruC makes psi65 in tRNAs.  This psi residue is not...; Region: PseudoU_synth_TruC; cd02563
374930002691	probable active site [active]
374930002692	Domain of unknown function, DUF446; Region: DUF446; cl01187
374930002693	tRNA s(4)U8 sulfurtransferase; Provisional; Region: PRK01269
374930002694	THUMP domain; Region: THUMP; cl12076
374930002695	ThiI is required for thiazole synthesis in the thiamine biosynthesis pathway. It belongs to the Adenosine Nucleotide Hydrolysis suoerfamily and predicted to bind to Adenosine nucleotide; Region: ThiI; cd01712
374930002696	Ligand Binding Site [chemical binding]; other site
374930002697	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
374930002698	active site residue [active]
374930002699	Exonuclease VII small subunit; Region: Exonuc_VII_S; cl00750
374930002700	Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142
374930002701	Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685
374930002702	substrate binding pocket [chemical binding]; other site
374930002703	chain length determination region; other site
374930002704	substrate-Mg2+ binding site; other site
374930002705	catalytic residues [active]
374930002706	aspartate-rich region 1; other site
374930002707	active site lid residues [active]
374930002708	aspartate-rich region 2; other site
374930002709	1-deoxy-D-xylulose-5-phosphate synthase; Region: dxs; TIGR00204
374930002710	TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products with important pharmaceutical activity. DXS...; Region: TPP_DXS; cd02007
374930002711	TPP-binding site; other site
374930002712	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
374930002713	PYR/PP interface [polypeptide binding]; other site
374930002714	dimer interface [polypeptide binding]; other site
374930002715	TPP binding site [chemical binding]; other site
374930002716	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
374930002717	Stringent starvation protein B; Region: SspB; cl01120
374930002718	stringent starvation protein A; Provisional; Region: sspA; PRK09481
374930002719	GST_N family, Stringent starvation protein A (SspA) subfamily; SspA is a RNA polymerase (RNAP)-associated protein required for the lytic development of phage P1 and for stationary phase-induced acid tolerance of E. coli. It is implicated in survival...; Region: GST_N_SspA; cd03059
374930002720	C-terminal domain interface [polypeptide binding]; other site
374930002721	putative GSH binding site (G-site) [chemical binding]; other site
374930002722	dimer interface [polypeptide binding]; other site
374930002723	GST_N family, Stringent starvation protein A (SspA) subfamily; SspA is a RNA polymerase (RNAP)-associated protein required for the lytic development of phage P1 and for stationary phase-induced acid tolerance of E. coli. It is implicated in survival...; Region: GST_C_SspA; cd03186
374930002724	dimer interface [polypeptide binding]; other site
374930002725	N-terminal domain interface [polypeptide binding]; other site
374930002726	Ribosomal protein S9/S16; Region: Ribosomal_S9; cl00334
374930002727	Ribosomal protein L13.  Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392
374930002728	23S rRNA interface [nucleotide binding]; other site
374930002729	L3 interface [polypeptide binding]; other site
374930002730	Methylenetetrahydrofolate reductase; Region: MTHFR; pfam02219
374930002731	Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine...; Region: MTHFR; cd00537
374930002732	FAD binding site [chemical binding]; other site
374930002733	CobQ/CobB/MinD/ParA nucleotide binding domain; Region: CbiA; pfam01656
374930002734	Ras-like GTPase superfamily. The Ras-like superfamily of small GTPases consists of several families with an extremely high degree of structural and functional similarity. The Ras superfamily is divided into at least four families in eukaryotes: the Ras...; Region: Ras_like_GTPase; cl10444
374930002735	Ras-like GTPase superfamily. The Ras-like superfamily of small GTPases consists of several families with an extremely high degree of structural and functional similarity. The Ras superfamily is divided into at least four families in eukaryotes: the Ras...; Region: Ras_like_GTPase; cl10444
374930002736	YcgL domain; Region: YcgL; cl01189
374930002737	GTP cyclohydrolase I (GTP-CH-I) catalyzes the conversion of GTP into dihydroneopterin triphosphate.  The enzyme product is the precursor of tetrahydrofolate in eubacteria, fungi, and plants and of the folate analogs in methanogenic bacteria.  In...; Region: GTP_cyclohydro1; cd00642
374930002738	homodecamer interface [polypeptide binding]; other site
374930002739	GTP cyclohydrolase I; Provisional; Region: PLN03044
374930002740	active site
374930002741	putative catalytic site residues [active]
374930002742	zinc binding site [ion binding]; other site
374930002743	GTP-CH-I/GFRP interaction surface; other site
374930002744	molybdopterin biosynthesis protein MoeA; Provisional; Region: PRK10680
374930002745	MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887
374930002746	dimer interface [polypeptide binding]; other site
374930002747	putative functional site; other site
374930002748	putative MPT binding site; other site
374930002749	molybdopterin biosynthesis protein MoeB; Provisional; Region: PRK05690
374930002750	ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of...; Region: ThiF_MoeB_HesA_family; cd00757
374930002751	ATP binding site [chemical binding]; other site
374930002752	substrate interface [chemical binding]; other site
374930002753	Protein of unknown function, DUF440; Region: DUF440; cl11472
374930002754	TlpA-like family; composed of  TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing...; Region: TlpA_like_family; cd02966
374930002755	catalytic residues [active]
374930002756	Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl00515
374930002757	Peptide methionine sulfoxide reductase; Region: PMSR; cl00366
374930002758	SelR domain; Region: SelR; cl00369
374930002759	Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950
374930002760	RNA polymerase sigma factor; Provisional; Region: PRK12530
374930002761	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
374930002762	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial...; Region: Sigma70_r4; cd06171
374930002763	DNA binding residues [nucleotide binding]
374930002764	YadA-like C-terminal region; Region: YadA; pfam03895
374930002765	Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538
374930002766	Outer membrane efflux protein; Region: OEP; pfam02321
374930002767	Outer membrane efflux protein; Region: OEP; pfam02321
374930002768	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
374930002769	catalytic core [active]
374930002770	phosphoglucosamine mutase; Provisional; Region: glmM; PRK10887
374930002771	GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of UDP-N-...; Region: GlmM; cd05802
374930002772	active site
374930002773	substrate binding site [chemical binding]; other site
374930002774	metal binding site [ion binding]; metal-binding site
374930002775	DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739
374930002776	dihydropteroate synthase; Region: DHPS; TIGR01496
374930002777	substrate binding pocket [chemical binding]; other site
374930002778	dimer interface [polypeptide binding]; other site
374930002779	inhibitor binding site; inhibition site
374930002780	potential frameshift: common BLAST hit: gi|68250004|ref|YP_249116.1| cell division protein FtsH homolog 1 [Haemophilus influenzae]
374930002781	putative 23S rRNA C2498 ribose 2'-O-ribose methyltransferase; Provisional; Region: PRK11760
374930002782	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440
374930002783	S-adenosylmethionine binding site [chemical binding]; other site
374930002784	CRS1 / YhbY (CRM) domain; Region: CRS1_YhbY; cl00663
374930002785	transcription elongation factor GreA; Reviewed; Region: greA; PRK00226
374930002786	domain; Region: GreA_GreB_N; pfam03449
374930002787	C-term; Region: GreA_GreB; pfam01272
374930002788	Beta-lactamase; Region: Beta-lactamase; cl01009
374930002789	PBP4 family; Region: PBP4; TIGR00666
374930002790	ISXO2-like transposase domain; Region: DDE_Tnp_IS1595; cl01481
374930002791	ISXO2-like transposase domain; Region: DDE_Tnp_IS1595; cl01481
374930002792	Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole...; Region: Ribosomal_S15p_S13e; cd00353
374930002793	16S/18S rRNA binding site [nucleotide binding]; other site
374930002794	S13e-L30e interaction site [polypeptide binding]; other site
374930002795	25S rRNA binding site [nucleotide binding]; other site
374930002796	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
374930002797	ATP binding site [chemical binding]; other site
374930002798	The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509
374930002799	active site 2 [active]
374930002800	active site 1 [active]
374930002801	Predicted ATP-dependent protease [Posttranslational modification, protein turnover, chaperones]; Region: LonB; COG1067
374930002802	Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362
374930002803	Organiser of macrodomain of Terminus of chromosome; Region: MatP; cl11476
374930002804	exodeoxyribonuclease V, alpha subunit; Region: recD; TIGR01447
374930002805	Putative ATPase (DUF699); Region: DUF699; pfam05127
374930002806	UvrD/REP helicase; Region: UvrD-helicase; cl14126
374930002807	exonuclease V subunit beta; Provisional; Region: recB; PRK10876
374930002808	UvrD/REP helicase; Region: UvrD-helicase; cl14126
374930002809	UvrD/REP helicase; Region: UvrD-helicase; cl14126
374930002810	CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641
374930002811	Ribosomal protein L20; Region: Ribosomal_L20; cd07026
374930002812	23S rRNA binding site [nucleotide binding]; other site
374930002813	L21 binding site [polypeptide binding]; other site
374930002814	L13 binding site [polypeptide binding]; other site
374930002815	Ribosomal protein L35; Region: Ribosomal_L35p; cl00392
374930002816	Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198
374930002817	Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707
374930002818	D-hexose-6-phosphate epimerase-like; Region: D-hex-6-P-epi_like; cd09020
374930002819	active site
374930002820	phosphate binding residues; other site
374930002821	catalytic residues [active]
374930002822	potential frameshift: common BLAST hit: gi|68249985|ref|YP_249097.1| predicted arylsulfatase A-like enzyme [Haemophilus influenzae]
374930002823	potential frameshift: common BLAST hit: gi|68249984|ref|YP_249096.1| predicted serine/threonine protein phosphatase family protein
374930002824	ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466
374930002825	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009
374930002826	Walker A motif; other site
374930002827	ATP binding site [chemical binding]; other site
374930002828	Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cl00120
374930002829	Active site [active]
374930002830	SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+...; Region: SIR2; cl00195
374930002831	Ftsk gamma domain; Region: Ftsk_gamma; cl09645
374930002832	Virulence protein [General function prediction only]; Region: COG3943
374930002833	Fic/DOC family; Region: Fic; cl00960
374930002834	Fic/DOC family; Region: Fic; cl00960
374930002835	Opioid growth factor receptor (OGFr) conserved region; Region: OGFr_N; pfam04664
374930002836	SIRT5_Af1_CobB: Eukaryotic, archaeal and prokaryotic group (class3) which includes human sirtuin SIRT5, Archaeoglobus fulgidus Sir2-Af1, and E. coli CobB; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes...; Region: SIRT5_Af1_CobB; cd01412
374930002837	NAD+ binding site [chemical binding]; other site
374930002838	substrate binding site [chemical binding]; other site
374930002839	Zn binding site [ion binding]; other site
374930002840	5' nucleotidase, deoxy (Pyrimidine), cytosolic type C protein (NT5C); Region: NT5C; cl01869
374930002841	Predicted transcriptional regulator [Transcription]; Region: COG2378
374930002842	NlpC/P60 family; Region: NLPC_P60; cl11438
374930002843	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and higher-...; Region: HU_IHF; cd00591
374930002844	IHF dimer interface [polypeptide binding]; other site
374930002845	IHF - DNA interface [nucleotide binding]; other site
374930002846	phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629
374930002847	tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain.  PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796
374930002848	putative tRNA-binding site [nucleotide binding]; other site
374930002849	B3/4 domain; Region: B3_4; cl11458
374930002850	tRNA synthetase B5 domain; Region: B5; cl08394
374930002851	Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA,  PheRS is an...; Region: PheRS_beta_core; cd00769
374930002852	dimer interface [polypeptide binding]; other site
374930002853	motif 1; other site
374930002854	motif 3; other site
374930002855	motif 2; other site
374930002856	Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147
374930002857	phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488
374930002858	Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912
374930002859	Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496
374930002860	dimer interface [polypeptide binding]; other site
374930002861	motif 1; other site
374930002862	active site
374930002863	motif 2; other site
374930002864	motif 3; other site
374930002865	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
374930002866	catalytic loop [active]
374930002867	iron binding site [ion binding]; other site
374930002868	dihydrodipicolinate reductase; Region: dapB; TIGR00036
374930002869	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
374930002870	Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173
374930002871	LysE type translocator; Region: LysE; cl00565
374930002872	Phosphatidylglycerophosphatase A; a bacterial membrane-associated enzyme involved in lipid metabolism; Region: PgpA; cd06971
374930002873	tetramer interfaces [polypeptide binding]; other site
374930002874	binuclear metal-binding site [ion binding]; other site
374930002875	thiamine-monophosphate kinase; Region: thiL; TIGR01379
374930002876	ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194
374930002877	ATP binding site [chemical binding]; other site
374930002878	dimerization interface [polypeptide binding]; other site
374930002879	Transcription termination factor NusB (N protein-Utilization Substance B). NusB plays a key role in the regulation of ribosomal RNA biosynthesis in eubacteria by modulating the efficiency of transcriptional antitermination. NusB along with other Nus...; Region: Terminator_NusB; cd00619
374930002880	putative RNA binding site [nucleotide binding]; other site
374930002881	lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209
374930002882	homopentamer interface [polypeptide binding]; other site
374930002883	active site
374930002884	asparaginyl-tRNA synthetase; Validated; Region: asnC; PRK03932
374930002885	EcAsnRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli asparaginyl-tRNA synthetase (AsnRS) and, in Arabidopsis thaliana and Saccharomyces cerevisiae mitochondrial (mt) AsnRS. This domain is a beta-barrel domain (...; Region: EcAsnRS_like_N; cd04318
374930002886	putative anticodon binding site; other site
374930002887	putative dimer interface [polypeptide binding]; other site
374930002888	Asx tRNA synthetase (AspRS/AsnRS) class II core domain.  Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well...; Region: AsxRS_core; cd00776
374930002889	homodimer interface [polypeptide binding]; other site
374930002890	motif 1; other site
374930002891	motif 2; other site
374930002892	active site
374930002893	motif 3; other site
374930002894	Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeA; cd00883
374930002895	active site clefts [active]
374930002896	zinc binding site [ion binding]; other site
374930002897	dimer interface [polypeptide binding]; other site
374930002898	potential frameshift: common BLAST hit: gi|68250142|ref|YP_249254.1| ABC transporter ATP-binding protein [Haemophilus influenzae]
374930002899	potential frameshift: common BLAST hit: gi|68250142|ref|YP_249254.1| ABC transporter ATP-binding protein [Haemophilus influenzae]
374930002900	type I site-specific deoxyribonuclease, HsdR family; Region: hsdR; TIGR00348
374930002901	bifunctional heptose 7-phosphate kinase/heptose 1-phosphate adenyltransferase; Provisional; Region: PRK11316
374930002902	RfaE encodes a bifunctional ADP-heptose synthase involved in the biosynthesis of the lipopolysaccharide (LPS) core precursor ADP-L-glycero-D-manno-heptose. LPS plays an important role in maintaining the structural integrity of the bacterial outer...; Region: RfaE_like; cd01172
374930002903	putative ribose interaction site [chemical binding]; other site
374930002904	putative ADP binding site [chemical binding]; other site
374930002905	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
374930002906	active site
374930002907	nucleotide binding site [chemical binding]; other site
374930002908	HIGH motif; other site
374930002909	KMSKS motif; other site
374930002910	potential frameshift: common BLAST hit: gi|68249956|ref|YP_249068.1| lipid A biosynthesis lauroyl acyltransferase [Haemophilus]
374930002911	DNA topoisomerase IV, B subunit, proteobacterial; Region: parE_Gneg; TIGR01055
374930002912	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
374930002913	ATP binding site [chemical binding]; other site
374930002914	Mg2+ binding site [ion binding]; other site
374930002915	G-X-G motif; other site
374930002916	TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are...; Region: TopoII_Trans_DNA_gyrase; cd00822
374930002917	anchoring element; other site
374930002918	dimer interface [polypeptide binding]; other site
374930002919	ATP binding site [chemical binding]; other site
374930002920	TOPRIM_TopoIIA_like: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to Saccharomyces cerevisiae Topoisomerase II. TopoIIA enzymes cut both...; Region: TOPRIM_TopoIIA_like; cd01030
374930002921	active site
374930002922	putative metal-binding site [ion binding]; other site
374930002923	DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986
374930002924	potential frameshift: common BLAST hit: gi|68249954|ref|YP_249066.1| DNA topoisomerase IV subunit A [Haemophilus influenzae 86-028NP]
374930002925	sodium--glutamate symport carrier (gltS); Region: gltS; TIGR00210
374930002926	alpha-L-glutamate ligases, RimK family; Region: rimK_fam; TIGR00768
374930002927	Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087
374930002928	Glutaredoxin (GRX) family; composed of GRX, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, catalyzing the disulfide reduction of target proteins such as ribonucleotide...; Region: GRX_family; cd02066
374930002929	GSH binding site [chemical binding]; other site
374930002930	catalytic residues [active]
374930002931	3-oxoacyl-(acyl carrier protein) synthase I; Reviewed; Region: PRK07967
374930002932	Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834
374930002933	dimer interface [polypeptide binding]; other site
374930002934	active site
374930002935	bifunctional tRNA (mnm(5)s(2)U34)-methyltransferase/FAD-dependent cmnm(5)s(2)U34 oxidoreductase; Reviewed; Region: mnmC; PRK01747
374930002936	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011
374930002937	Malate:quinone oxidoreductase (Mqo); Region: Mqo; cl14881
374930002938	Choline Kinase (ChoK). The ChoK subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs), RIO kinases, actin-fragmin kinase (AFK), and...; Region: ChoK; cd05151
374930002939	active site
374930002940	ATP binding site [chemical binding]; other site
374930002941	Phosphotransferase enzyme family; Region: APH; pfam01636
374930002942	substrate binding site [chemical binding]; other site
374930002943	dimer interface [polypeptide binding]; other site
374930002944	EamA-like transporter family; Region: EamA; cl01037
374930002945	Phosphocholine cytidylyltransferases catalyze the synthesis of CDP-choline; Region: PC_cytidylyltransferase; cd02523
374930002946	active site
374930002947	metal binding site [ion binding]; metal-binding site
374930002948	potential frameshift: common BLAST hit: gi|68249945|ref|YP_249057.1| phosphorylcholine transferase [Haemophilus influenzae 86-028NP]
374930002949	potential frameshift: common BLAST hit: gi|68249944|ref|YP_249056.1| protease IV [Haemophilus influenzae 86-028NP]
374930002950	Nitroreductase-like family which includes NADH oxidase and arsenite oxidiase. NADH oxidase catalyses the oxidation of NAD(P)H and accepts a wide broad range of compounds as electron acceptors, such as nitrocompound. Arsenite oxidase in a beta-...; Region: Arsenite_oxidase; cd02135
374930002951	putative FMN binding site [chemical binding]; other site
374930002952	Nitrate reductase delta subunit; Region: Nitrate_red_del; cl00958
374930002953	NADPH-dependent FMN reductase; Region: FMN_red; cl00438
374930002954	Sodium:dicarboxylate symporter family; Region: SDF; cl00573
374930002955	SOS-response transcriptional repressors (RecA-mediated autopeptidases) [Transcription / Signal transduction mechanisms]; Region: LexA; COG1974
374930002956	The S24, S26 LexA/signal peptidase superfamily contains LexA-related and type I signal peptidase families. The S24 LexA protein domains include: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC 3.4.21.88)...; Region: Peptidase_S24_S26; cl10465
374930002957	NeuB family; Region: NeuB; cl00496
374930002958	DAHP synthetase I family; Region: DAHP_synth_1; pfam00793
374930002959	outer membrane-specific lipoprotein transporter subunit LolE; Provisional; Region: PRK11146
374930002960	FtsX-like permease family; Region: FtsX; pfam02687
374930002961	lipoprotein releasing system, ATP-binding protein; Region: LolD_lipo_ex; TIGR02211
374930002962	This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE).  They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255
374930002963	Walker A/P-loop; other site
374930002964	ATP binding site [chemical binding]; other site
374930002965	Q-loop/lid; other site
374930002966	ABC transporter signature motif; other site
374930002967	Walker B; other site
374930002968	D-loop; other site
374930002969	H-loop/switch region; other site
374930002970	Ras-like GTPase superfamily. The Ras-like superfamily of small GTPases consists of several families with an extremely high degree of structural and functional similarity. The Ras superfamily is divided into at least four families in eukaryotes: the Ras...; Region: Ras_like_GTPase; cl10444
374930002971	Dethiobiotin synthetase (DTBS) is the penultimate enzyme in the biotin biosynthesis pathway in Escherichia coli and other microorganisms. The enzyme catalyzes formation of the ureido ring of dethiobiotin from (7R,8S)-7,8-diaminononanoic acid (DAPA) and...; Region: DTBS; cd03109
374930002972	ADP binding site [chemical binding]; other site
374930002973	biotin biosynthesis protein BioC; Region: BioC; TIGR02072
374930002974	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011
374930002975	Protein of unknown function (DUF452); Region: DUF452; cl01062
374930002976	7-keto-8-aminopelargonate synthetase and related enzymes [Coenzyme metabolism]; Region: BioF; COG0156
374930002977	KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS), 8-amino-7-...; Region: KBL_like; cd06454
374930002978	substrate-cofactor binding pocket; other site
374930002979	pyridoxal 5'-phosphate binding site [chemical binding]; other site
374930002980	catalytic residue [active]
374930002981	adenosylmethionine--8-amino-7-oxononanoate transaminase; Provisional; Region: PRK06173
374930002982	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase...; Region: OAT_like; cd00610
374930002983	inhibitor-cofactor binding pocket; inhibition site
374930002984	pyridoxal 5'-phosphate binding site [chemical binding]; other site
374930002985	catalytic residue [active]
374930002986	LolC/E family; Region: lolCE; TIGR02212
374930002987	FtsX-like permease family; Region: FtsX; pfam02687
374930002988	glycerate dehydrogenase; Provisional; Region: PRK06932
374930002989	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
374930002990	NeuB family; Region: NeuB; cl00496
374930002991	DAHP synthetase I family; Region: DAHP_synth_1; pfam00793
374930002992	Uncharacterized conserved protein [Function unknown]; Region: COG2912
374930002993	hypothetical protein; Provisional; Region: PRK10941
374930002994	N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328
374930002995	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011
374930002996	RDD family; Region: RDD; cl00746
374930002997	peptide chain release factor 1; Validated; Region: prfA; PRK00591
374930002998	RF-1 domain; Region: RF-1; cl02875
374930002999	RF-1 domain; Region: RF-1; cl02875
374930003000	FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790
374930003001	Sel1 repeat; Region: Sel1; cl02723
374930003002	Sel1 repeat; Region: Sel1; cl02723
374930003003	Sel1 repeat; Region: Sel1; cl02723
374930003004	Sel1 repeat; Region: Sel1; cl02723
374930003005	Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446
374930003006	Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446
374930003007	FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790
374930003008	Sel1 repeat; Region: Sel1; cl02723
374930003009	Sel1 repeat; Region: Sel1; cl02723
374930003010	Sel1 repeat; Region: Sel1; cl02723
374930003011	Sel1 repeat; Region: Sel1; cl02723
374930003012	Sel1 repeat; Region: Sel1; cl02723
374930003013	Sel1 repeat; Region: Sel1; cl02723
374930003014	Sel1 repeat; Region: Sel1; cl02723
374930003015	Sel1 repeat; Region: Sel1; cl02723
374930003016	Sel1 repeat; Region: Sel1; cl02723
374930003017	Protein of unknown function, DUF462; Region: DUF462; cl01190
374930003018	Phage virion morphogenesis family; Region: Phage_tail_S; cl02089
374930003019	Mu-like prophage protein gp29 [Function unknown]; Region: COG4383
374930003020	pyruvate kinase; Provisional; Region: PRK05826
374930003021	Pyruvate kinase (PK):  Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cd00288
374930003022	domain interfaces; other site
374930003023	active site
374930003024	potential frameshift: common BLAST hit: gi|68249840|ref|YP_248952.1| replicative DNA helicase [Haemophilus influenzae 86-028NP]
374930003025	potential frameshift: common BLAST hit: gi|16273469|ref|NP_439720.1| replicative DNA helicase [Haemophilus influenzae Rd KW20]
374930003026	alanine racemase; Reviewed; Region: alr; PRK00053
374930003027	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, Proteobacterial Alanine Racemases; Region: PLPDE_III_AR_proteobact; cd06827
374930003028	active site
374930003029	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
374930003030	substrate binding site [chemical binding]; other site
374930003031	catalytic residues [active]
374930003032	dimer interface [polypeptide binding]; other site
374930003033	glucose-6-phosphate isomerase; Reviewed; Region: pgi; PRK00179
374930003034	Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015
374930003035	active site
374930003036	dimer interface [polypeptide binding]; other site
374930003037	Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016
374930003038	dimer interface [polypeptide binding]; other site
374930003039	active site
374930003040	potential frameshift: common BLAST hit: gi|68249837|ref|YP_248949.1| UDP-glcNAc--lipooligosaccharide N-acetylglucosamine
374930003041	Glycine zipper 2TM domain; Region: Rick_17kDa_Anti; cl10470
374930003042	Arginyl tRNA synthetase N terminal domain; Region: Arg_tRNA_synt_N; pfam03485
374930003043	arginyl-tRNA synthetase; Region: argS; TIGR00456
374930003044	catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671
374930003045	active site
374930003046	HIGH motif; other site
374930003047	KMSK motif region; other site
374930003048	Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956
374930003049	tRNA binding surface [nucleotide binding]; other site
374930003050	anticodon binding site; other site
374930003051	acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895
374930003052	N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878
374930003053	putative valine binding site [chemical binding]; other site
374930003054	dimer interface [polypeptide binding]; other site
374930003055	Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369
374930003056	acetolactate synthase 3 catalytic subunit; Validated; Region: PRK06882
374930003057	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
374930003058	PYR/PP interface [polypeptide binding]; other site
374930003059	dimer interface [polypeptide binding]; other site
374930003060	TPP binding site [chemical binding]; other site
374930003061	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
374930003062	Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015
374930003063	TPP-binding site [chemical binding]; other site
374930003064	dimer interface [polypeptide binding]; other site
374930003065	Na+/H+ antiporter [Energy production and conversion]; Region: NhaC; COG1757
374930003066	Anion permease ArsB/NhaD.  These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life.  A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl09110
374930003067	Domain in histone-like proteins of HNS family; Region: HNS; cl09251
374930003068	formyltetrahydrofolate deformylase; Reviewed; Region: purU; PRK06027
374930003069	N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875
374930003070	Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648
374930003071	putative active site [active]
374930003072	putative substrate binding site [chemical binding]; other site
374930003073	putative cosubstrate binding site; other site
374930003074	catalytic site [active]
374930003075	3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427
374930003076	EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form 5-enolpyruvylshkimate-3-...; Region: EPSP_synthase; cd01556
374930003077	hinge; other site
374930003078	active site
374930003079	potential frameshift: common BLAST hit: gi|68249825|ref|YP_248937.1| modification methylase BepI-like [Haemophilus influenzae 86-028NP]
374930003080	recombination factor protein RarA; Reviewed; Region: PRK13342
374930003081	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009
374930003082	Walker A motif; other site
374930003083	ATP binding site [chemical binding]; other site
374930003084	Walker B motif; other site
374930003085	arginine finger; other site
374930003086	MgsA AAA+ ATPase C terminal; Region: MgsA_C; cl13440
374930003087	Outer membrane lipoprotein carrier protein LolA; Region: LolA; cl01065
374930003088	lipoprotein chaperone; Reviewed; Region: lolA; PRK00031
374930003089	DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674
374930003090	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099
374930003091	Ftsk gamma domain; Region: Ftsk_gamma; cl09645
374930003092	leucine-responsive transcriptional regulator; Provisional; Region: PRK11169
374930003093	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088
374930003094	DNA repair protein RadA; Region: sms; TIGR00416
374930003095	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099
374930003096	Walker A motif; other site
374930003097	ATP binding site [chemical binding]; other site
374930003098	Walker B motif; other site
374930003099	Uncharacterized subgroup of the CYTH-like superfamily having an associated CHAD domain; Region: CYTH-like_Pase_CHAD; cd07756
374930003100	putative active site [active]
374930003101	putative metal binding residues [ion binding]; other site
374930003102	signature motif; other site
374930003103	putative triphosphate binding site [ion binding]; other site
374930003104	haemagglutination activity domain; Region: Haemagg_act; cl05436
374930003105	Equine herpesvirus glycoprotein gp2; Region: Herpes_gp2; pfam05955
374930003106	Surface antigen; Region: Bac_surface_Ag; cl03097
374930003107	Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones]; Region: Spy; COG3914
374930003108	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist...; Region: TM_ABC_iron-siderophores_like; cl00462
374930003109	Mor transcription activator family; Region: Mor; cl02360
374930003110	Uncharacterized protein conserved in bacteria (DUF2063); Region: DUF2063; cl01262
374930003111	hypothetical protein; Provisional; Region: PRK05409
374930003112	Protein of unknown function (DUF692); Region: DUF692; cl01263
374930003113	potential frameshift: common BLAST hit: gi|68249808|ref|YP_248920.1| predicted membrane protein [Haemophilus influenzae 86-028NP]
374930003114	TIGR00153 family protein; Region: TIGR00153
374930003115	Phosphate transporter family; Region: PHO4; cl00396
374930003116	Phosphate transporter family; Region: PHO4; cl00396
374930003117	SH3 domain protein [Signal transduction mechanisms]; Region: COG3103
374930003118	Bacterial SH3 domain; Region: SH3_3; cl02551
374930003119	multifunctional tRNA nucleotidyl transferase/2'3'-cyclic phosphodiesterase/2'nucleotidase/phosphatase; Reviewed; Region: cca; PRK10885
374930003120	Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398
374930003121	active site
374930003122	NTP binding site [chemical binding]; other site
374930003123	metal binding triad [ion binding]; metal-binding site
374930003124	Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627
374930003125	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076
374930003126	outer membrane lipoprotein LolB; Region: lolB; TIGR00548
374930003127	Outer membrane lipoprotein LolB; Region: LolB; pfam03550
374930003128	4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: ipk; PRK00343
374930003129	GHMP kinases N terminal domain; Region: GHMP_kinases_N; cl08256
374930003130	GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544
374930003131	ribose-phosphate pyrophosphokinase; Provisional; Region: PRK04923
374930003132	Phosphoribosyl transferase domain; Region: Pribosyltran; cl00309
374930003133	potential frameshift: common BLAST hit: gi|68249800|ref|YP_248912.1| tyrosyl-tRNA synthetase [Haemophilus influenzae 86-028NP]
374930003134	Sugar fermentation stimulation protein; Region: SfsA; cl00647
374930003135	multidrug efflux protein; Reviewed; Region: PRK01766
374930003136	MatE; Region: MatE; pfam01554
374930003137	MatE; Region: MatE; pfam01554
374930003138	riboflavin synthase subunit alpha; Provisional; Region: PRK13020
374930003139	Lumazine binding domain; Region: Lum_binding; pfam00677
374930003140	Lumazine binding domain; Region: Lum_binding; pfam00677
374930003141	aminopeptidase N; Provisional; Region: pepN; PRK14015
374930003142	Peptidase M1 family containing Aminopeptidase N; Region: M1_APN_1; cd09600
374930003143	active site
374930003144	Zn binding site [ion binding]; other site
374930003145	Predicted nuclease of the RNAse H fold, HicB family [General    function prediction only]; Region: HicB; COG4226
374930003146	HicB family; Region: HicB; pfam05534
374930003147	AIR carboxylase; Region: AIRC; cl00310
374930003148	phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019
374930003149	Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087
374930003150	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
374930003151	pyridoxal 5'-phosphate binding site [chemical binding]; other site
374930003152	homodimer interface [polypeptide binding]; other site
374930003153	catalytic residue [active]
374930003154	Domain I of the ABC component of a cobalt transport family found in bacteria, archaea, and eukaryota.  The transition metal cobalt is an essential component of many enzymes and must be transported into cells in appropriate amounts when needed.  This...; Region: ABC_cobalt_CbiO_domain1; cd03225
374930003155	cobalt transport protein ATP-binding subunit; Region: cbiO; TIGR01166
374930003156	Walker A/P-loop; other site
374930003157	ATP binding site [chemical binding]; other site
374930003158	Q-loop/lid; other site
374930003159	ABC transporter signature motif; other site
374930003160	Walker B; other site
374930003161	D-loop; other site
374930003162	H-loop/switch region; other site
374930003163	Cobalt transport protein; Region: CbiQ; cl00463
374930003164	Cobalt uptake substrate-specific transmembrane region; Region: CbiM; cl00397
374930003165	ABC-type Co2+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: CbiK; COG5266
374930003166	Nickel uptake substrate-specific transmembrane region; Region: NikM; pfam10670
374930003167	Helix-Turn-Helix DNA binding domain of the CadR and PbrR transcription regulators; Region: HTH_CadR-PbrR; cd04784
374930003168	Hg(II)-responsive transcriptional regulator; Region: MerR; TIGR02051
374930003169	DNA binding residues [nucleotide binding]
374930003170	dimer interface [polypeptide binding]; other site
374930003171	putative metal binding site [ion binding]; other site
374930003172	FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790
374930003173	Sel1 repeat; Region: Sel1; cl02723
374930003174	Sel1 repeat; Region: Sel1; cl02723
374930003175	This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function.  The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_2; cd06150
374930003176	homotrimer interaction site [polypeptide binding]; other site
374930003177	putative active site [active]
374930003178	Protein of unknown function (DUF1043); Region: DUF1043; cl11473
374930003179	SNARE associated Golgi protein; Region: SNARE_assoc; cl00429
374930003180	Ribosomal_L25_TL5_CTC: Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain. L25 is a single-domain protein, homologous to the N-terminal domain of TL5 and CTC, which each contain two domains. CTC is a known stress protein, and proteins of this...; Region: Ribosomal_L25_TL5_CTC; cd00495
374930003181	5S rRNA interface [nucleotide binding]; other site
374930003182	CTC domain interface; other site
374930003183	L16 interface [polypeptide binding]; other site
374930003184	Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452
374930003185	substrate binding site [chemical binding]; other site
374930003186	nucleotide binding site [chemical binding]; other site
374930003187	ACT domains located C-terminal to the catalytic domain of the lysine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-LysC-EC_2; cd04917
374930003188	dimer interface [polypeptide binding]; other site
374930003189	adenylosuccinate synthetase; Provisional; Region: PRK01117
374930003190	Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the r-...; Region: AdSS; cd03108
374930003191	GDP-binding site [chemical binding]; other site
374930003192	ACT binding site; other site
374930003193	IMP binding site; other site
374930003194	2,3,4,5-tetrahydropyridine-2,6-carboxylate N-succinyltransferase; Provisional; Region: dapD; PRK11830
374930003195	2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (also called THP succinyltransferase): THDP N-succinyltransferase catalyzes the conversion of tetrahydrodipicolinate and succinyl-CoA to N-succinyltetrahydrodipicolinate and CoA...; Region: LbH_THP_succinylT; cd03350
374930003196	trimer interface [polypeptide binding]; other site
374930003197	active site
374930003198	substrate binding site [chemical binding]; other site
374930003199	CoA binding site [chemical binding]; other site
374930003200	similar to hypothetical protein; COG2171 Tetrahydrodipicolinate N-succinyltransferase
374930003201	DNA-binding transcriptional repressor PurR; Provisional; Region: PRK10703
374930003202	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
374930003203	DNA binding site [nucleotide binding]
374930003204	domain linker motif; other site
374930003205	Ligand-binding domain of purine repressor, PurR, which functions as the master regulatory protein of de novo purine nucleotide biosynthesis in Escherichia coli; Region: PBP1_PurR; cd06275
374930003206	dimerization interface [polypeptide binding]; other site
374930003207	ligand binding site [chemical binding]; other site
374930003208	Phosphoenolpyruvate carboxylase [Carbohydrate transport and    metabolism; Energy production and conversion]; Region: COG1892; cl14656
374930003209	Phosphoenolpyruvate carboxylase [Energy production and conversion]; Region: Ppc; COG2352
374930003210	putative transposase OrfB; Reviewed; Region: PHA02517
374930003211	Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315
374930003212	DNA-methyltransferase (dcm); Region: dcm; TIGR00675
374930003213	cofactor binding site; other site
374930003214	DNA binding site [nucleotide binding]
374930003215	substrate interaction site [chemical binding]; other site
374930003216	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011
374930003217	Predicted restriction endonuclease [Defense mechanisms]; Region: COG3440
374930003218	YcjX-like family, DUF463; Region: DUF463; cl01193
374930003219	ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166
374930003220	The substrate-binding component of an ABC-type dipeptide import system contains the type 2 periplasmic binding fold; Region: PBP2_DppA_like; cd08493
374930003221	peptide binding site [polypeptide binding]; other site
374930003222	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SapB; COG4168
374930003223	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261
374930003224	dimer interface [polypeptide binding]; other site
374930003225	conserved gate region; other site
374930003226	putative PBP binding loops; other site
374930003227	ABC-ATPase subunit interface; other site
374930003228	potential frameshift: common BLAST hit: gi|68249770|ref|YP_248882.1| ABC-type transport system, permease protein
374930003229	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SapD; COG4170
374930003230	The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE).  The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257
374930003231	Walker A/P-loop; other site
374930003232	ATP binding site [chemical binding]; other site
374930003233	Q-loop/lid; other site
374930003234	ABC transporter signature motif; other site
374930003235	Walker B; other site
374930003236	D-loop; other site
374930003237	H-loop/switch region; other site
374930003238	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
374930003239	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SapF; COG4167
374930003240	The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE).  The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257
374930003241	Walker A/P-loop; other site
374930003242	ATP binding site [chemical binding]; other site
374930003243	Q-loop/lid; other site
374930003244	ABC transporter signature motif; other site
374930003245	Walker B; other site
374930003246	D-loop; other site
374930003247	H-loop/switch region; other site
374930003248	Conserved hypothetical protein 698; Region: Cons_hypoth698; cl01075
374930003249	potential frameshift: common BLAST hit: gi|68249766|ref|YP_248878.1| tRNA pseudouridine synthase A [Haemophilus influenzae 86-028NP]
374930003250	Fructose-1,6-bisphosphatase, an enzyme that catalyzes the hydrolysis of fructose-1,6-biphosphate  into fructose-6-phosphate and is critical in gluconeogenesis pathway. The alignment model also includes chloroplastic FBPases and sedoheptulose-1,7-...; Region: FBPase; cd00354
374930003251	AMP binding site [chemical binding]; other site
374930003252	metal binding site [ion binding]; metal-binding site
374930003253	active site
374930003254	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099
374930003255	Active site [active]
374930003256	L-lactate permease; Region: Lactate_perm; cl00701
374930003257	glycolate transporter; Provisional; Region: PRK09695
374930003258	potential frameshift: common BLAST hit: gi|16273136|ref|NP_439373.1| transferrin-binding protein [Haemophilus influenzae Rd KW20]
374930003259	Phosphorylase superfamily; Region: PNP_UDP_1; cl00303
374930003260	DsbA family, DsbA subfamily; DsbA is a monomeric thiol disulfide oxidoreductase protein containing a redox active CXXC motif imbedded in a TRX fold. It is involved in the oxidative protein folding pathway in prokaryotes, and is the strongest thiol...; Region: DsbA_DsbA; cd03019
374930003261	catalytic residues [active]
374930003262	hinge region; other site
374930003263	alpha helical domain; other site
374930003264	ssDNA exonuclease RecJ; Provisional; Region: PRK11070
374930003265	ssDNA exonuclease RecJ; Provisional; Region: PRK11070
374930003266	DHH family; Region: DHH; pfam01368
374930003267	DHHA1 domain; Region: DHHA1; pfam02272
374930003268	protein disulfide isomerase II DsbC; Provisional; Region: PRK10877
374930003269	DsbA family, DsbC and DsbG subfamily; V-shaped homodimeric proteins containing a redox active CXXC motif imbedded in a TRX fold. They function as protein disulfide isomerases and chaperones in the bacterial periplasm to correct non-native disulfide...; Region: DsbA_DsbC_DsbG; cd03020
374930003270	dimerization domain [polypeptide binding]; other site
374930003271	dimer interface [polypeptide binding]; other site
374930003272	catalytic residues [active]
374930003273	RF-1 domain; Region: RF-1; cl02875
374930003274	Protein chain release factor B [Translation, ribosomal structure and biogenesis]; Region: PrfB; COG1186
374930003275	RF-1 domain; Region: RF-1; cl02875
374930003276	lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484
374930003277	LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-...; Region: LysRS_N; cd04322
374930003278	dimer interface [polypeptide binding]; other site
374930003279	putative anticodon binding site; other site
374930003280	Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775
374930003281	motif 1; other site
374930003282	active site
374930003283	motif 2; other site
374930003284	motif 3; other site
374930003285	malate dehydrogenase; Provisional; Region: PRK05086
374930003286	Glyoxysomal and mitochondrial malate dehydrogenases; Region: MDH_glyoxysomal_mitochondrial; cd01337
374930003287	NAD binding site [chemical binding]; other site
374930003288	dimerization interface [polypeptide binding]; other site
374930003289	Substrate binding site [chemical binding]; other site
374930003290	arginine repressor; Provisional; Region: PRK05066
374930003291	Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316
374930003292	Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863
374930003293	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
374930003294	TIGR01777 family protein; Region: yfcH
374930003295	NAD(P) binding site [chemical binding]; other site
374930003296	active site
374930003297	amidophosphoribosyltransferase; Provisional; Region: PRK09246
374930003298	Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of  glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715
374930003299	active site
374930003300	tetramer interface [polypeptide binding]; other site
374930003301	Phosphoribosyl transferase domain; Region: Pribosyltran; cl00309
374930003302	potential frameshift: common BLAST hit: gi|68249752|ref|YP_248864.1| colicin V production protein [Haemophilus influenzae 86-028NP]
374930003303	Protein of unknown function, DUF412; Region: DUF412; cl01183
374930003304	Acetokinase family; Region: Acetate_kinase; cl01029
374930003305	phosphate acetyltransferase; Reviewed; Region: PRK05632
374930003306	Ras-like GTPase superfamily. The Ras-like superfamily of small GTPases consists of several families with an extremely high degree of structural and functional similarity. The Ras superfamily is divided into at least four families in eukaryotes: the Ras...; Region: Ras_like_GTPase; cl10444
374930003307	DRTGG domain; Region: DRTGG; cl12147
374930003308	Phosphate acetyl/butaryl transferase; Region: PTA_PTB; cl00390
374930003309	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2840
374930003310	Smr domain; Region: Smr; cl02619
374930003311	HemK family putative methylases; Region: hemK_fam; TIGR00536
374930003312	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440
374930003313	S-adenosylmethionine binding site [chemical binding]; other site
374930003314	transcriptional regulator CysB; Reviewed; Region: cysB; PRK12681
374930003315	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088
374930003316	The C-terminal substrate domain of LysR-type transcriptional regulators CysB-like contains type 2 periplasmic binding fold; Region: PBP2_CysB_like; cd08413
374930003317	substrate binding site [chemical binding]; other site
374930003318	dimerization interface [polypeptide binding]; other site
374930003319	23S rRNA pseudouridylate synthase B; Provisional; Region: PRK10700
374930003320	PseudoU_synth_RluB: Pseudouridine synthase, Escherichia coli RluB like. This group is comprised of bacterial and eukaryotic proteins similar to E. coli RluB. Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to...; Region: PseudoU_synth_RluB; cd02556
374930003321	probable active site [active]
374930003322	yrdC domain; Region: Sua5_yciO_yrdC; cl00305
374930003323	succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678
374930003324	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
374930003325	CoA-ligase; Region: Ligase_CoA; pfam00549
374930003326	succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696
374930003327	Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087
374930003328	CoA-ligase; Region: Ligase_CoA; pfam00549
374930003329	putative 23S rRNA C2498 ribose 2'-O-ribose methyltransferase; Provisional; Region: PRK11760
374930003330	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011
374930003331	DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139
374930003332	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088
374930003333	HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432
374930003334	dimerization interface [polypeptide binding]; other site
374930003335	substrate binding pocket [chemical binding]; other site
374930003336	branched-chain amino acid aminotransferase; Provisional; Region: PRK13357
374930003337	BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids  leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and alpha-...; Region: BCAT_beta_family; cd01557
374930003338	homodimer interface [polypeptide binding]; other site
374930003339	substrate-cofactor binding pocket; other site
374930003340	catalytic residue [active]
374930003341	ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995
374930003342	Ligand Binding Site [chemical binding]; other site
374930003343	Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1),  6-pyrovoyl...; Region: TFold; cl00263
374930003344	active site
374930003345	Organic radical activating enzymes [Posttranslational modification, protein turnover, chaperones]; Region: NrdG; COG0602
374930003346	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster...; Region: Radical_SAM; cd01335
374930003347	FeS/SAM binding site; other site
374930003348	NIF3 (NGG1p interacting factor 3); Region: NIF3; cl01309
374930003349	DNA-dependent helicase II; Provisional; Region: uvrD; PRK11773
374930003350	UvrD/REP helicase; Region: UvrD-helicase; cl14126
374930003351	potential frameshift: common BLAST hit: gi|68249733|ref|YP_248845.1| dipeptide transport system permease protein [Haemophilus influenzae]
374930003352	dipeptide transporter; Provisional; Region: PRK10913
374930003353	N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911
374930003354	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261
374930003355	dimer interface [polypeptide binding]; other site
374930003356	conserved gate region; other site
374930003357	putative PBP binding loops; other site
374930003358	ABC-ATPase subunit interface; other site
374930003359	dipeptide transporter ATP-binding subunit; Provisional; Region: dppD; PRK11022
374930003360	The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE).  The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257
374930003361	Walker A/P-loop; other site
374930003362	ATP binding site [chemical binding]; other site
374930003363	Q-loop/lid; other site
374930003364	ABC transporter signature motif; other site
374930003365	Walker B; other site
374930003366	D-loop; other site
374930003367	H-loop/switch region; other site
374930003368	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
374930003369	dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308
374930003370	The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE).  The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257
374930003371	Walker A/P-loop; other site
374930003372	ATP binding site [chemical binding]; other site
374930003373	Q-loop/lid; other site
374930003374	ABC transporter signature motif; other site
374930003375	Walker B; other site
374930003376	D-loop; other site
374930003377	H-loop/switch region; other site
374930003378	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
374930003379	Adenylation domain of kDNA ligases and similar proteins; Region: Adenylation_kDNA_ligase_like; cd07896
374930003380	active site
374930003381	ATP-dependent DNA ligase; Reviewed; Region: ligB; PRK07636
374930003382	DNA binding site [nucleotide binding]
374930003383	The Oligonucleotide/oligosaccharide binding (OB)-fold domain of kDNA ligase-like ATP-dependent DNA ligases is a DNA-binding module that is part of the catalytic core unit; Region: OBF_kDNA_ligase_like; cd08041
374930003384	DNA binding site [nucleotide binding]
374930003385	Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006
374930003386	dimer interface [polypeptide binding]; other site
374930003387	active site
374930003388	arginine transporter ATP-binding subunit; Provisional; Region: artP; PRK11124
374930003389	HisP and GlnQ are the ATP-binding components of the bacterial periplasmic histidine and glutamine permeases, repectively.  Histidine permease is a multisubunit complex containing the HisQ and HisM integral membrane subunits and two copies of HisP; Region: ABC_HisP_GlnQ_permeases; cd03262
374930003390	Walker A/P-loop; other site
374930003391	ATP binding site [chemical binding]; other site
374930003392	Q-loop/lid; other site
374930003393	ABC transporter signature motif; other site
374930003394	Walker B; other site
374930003395	D-loop; other site
374930003396	H-loop/switch region; other site
374930003397	lysine-arginine-ornithine-binding periplasmic protein; Region: 3A0103s03R; TIGR01096
374930003398	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and...; Region: PBPb; cd00134
374930003399	substrate binding pocket [chemical binding]; other site
374930003400	membrane-bound complex binding site; other site
374930003401	hinge residues; other site
374930003402	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
374930003403	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261
374930003404	dimer interface [polypeptide binding]; other site
374930003405	conserved gate region; other site
374930003406	putative PBP binding loops; other site
374930003407	ABC-ATPase subunit interface; other site
374930003408	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261
374930003409	dimer interface [polypeptide binding]; other site
374930003410	conserved gate region; other site
374930003411	putative PBP binding loops; other site
374930003412	ABC-ATPase subunit interface; other site
374930003413	YadA-like C-terminal region; Region: YadA; pfam03895
374930003414	Surface antigen; Region: Surface_Ag_2; cl01155
374930003415	SprT homologues; Region: SprT; cl01182
374930003416	S-adenosylmethionine synthetase; Validated; Region: PRK05250
374930003417	S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438
374930003418	S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772
374930003419	S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773
374930003420	Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743
374930003421	Glutamine amidotransferase class-I; Region: GATase; pfam00117
374930003422	glutamine binding [chemical binding]; other site
374930003423	catalytic triad [active]
374930003424	chorismate binding enzyme; Region: Chorismate_bind; cl10555
374930003425	PyridoxaL 5'-Phosphate Dependent Enzymes class IV (PLPDE_IV). This D-amino acid superfamily, one of five classes of PLPDE, consists of branched-chain amino acid aminotransferases (BCAT), D-amino acid transferases (DAAT), and 4-amino-4-deoxychorismate...; Region: PLPDE_IV; cl00224
374930003426	substrate-cofactor binding pocket; other site
374930003427	Protein of unknown function (DUF496); Region: DUF496; cl09955
374930003428	Phosphoserine aminotransferase (PSAT) family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major group in this CD corresponds to phosphoserine aminotransferase (PSAT).  PSAT is active...; Region: PSAT_like; cd00611
374930003429	homodimer interface [polypeptide binding]; other site
374930003430	substrate-cofactor binding pocket; other site
374930003431	pyridoxal 5'-phosphate binding site [chemical binding]; other site
374930003432	catalytic residue [active]
374930003433	potential frameshift: common BLAST hit: gi|68249714|ref|YP_248826.1| putative aminotransferase [Haemophilus influenzae 86-028NP]
374930003434	Glutaredoxin (GRX) family, PKC-interacting cousin of TRX (PICOT)-like subfamily; composed of PICOT and GRX-PICOT-like proteins. The non-PICOT members of this family contain only the GRX-like domain, whereas PICOT contains an N-terminal TRX-like domain...; Region: GRX_PICOT_like; cd03028
374930003435	putative GSH binding site [chemical binding]; other site
374930003436	catalytic residues [active]
374930003437	Surface antigen; Region: Surface_Ag_2; cl01155
374930003438	Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885
374930003439	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
374930003440	ligand binding site [chemical binding]; other site
374930003441	FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277
374930003442	FAD binding domain; Region: FAD_binding_4; pfam01565
374930003443	Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247
374930003444	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
374930003445	CoenzymeA binding site [chemical binding]; other site
374930003446	subunit interaction site [polypeptide binding]; other site
374930003447	PHB binding site; other site
374930003448	ferrochelatase; Region: hemH; TIGR00109
374930003449	Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411
374930003450	C-terminal domain interface [polypeptide binding]; other site
374930003451	active site
374930003452	Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419
374930003453	active site
374930003454	N-terminal domain interface [polypeptide binding]; other site
374930003455	Thioredoxin domain-containing protein [Posttranslational modification, protein turnover, chaperones]; Region: COG3118
374930003456	ybbN protein family; ybbN is a hypothetical protein containing a redox-inactive TRX-like domain. Its gene has been sequenced from several gammaproteobacteria and actinobacteria; Region: ybbN; cd02956
374930003457	thioredoxin reductase; Provisional; Region: PRK10262
374930003458	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644
374930003459	cysteine/glutathione ABC transporter membrane/ATP-binding component; Reviewed; Region: PRK11174
374930003460	ABC transporter transmembrane region; Region: ABC_membrane; cl00549
374930003461	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099
374930003462	Walker A/P-loop; other site
374930003463	ATP binding site [chemical binding]; other site
374930003464	Q-loop/lid; other site
374930003465	ABC transporter signature motif; other site
374930003466	Walker B; other site
374930003467	D-loop; other site
374930003468	H-loop/switch region; other site
374930003469	cysteine/glutathione ABC transporter membrane/ATP-binding component; Reviewed; Region: PRK11160
374930003470	ABC transporter transmembrane region; Region: ABC_membrane; cl00549
374930003471	The CYD subfamily implicated in cytochrome bd biogenesis.  The CydC and CydD proteins are important for the formation of cytochrome bd terminal oxidase of E. coli and it has been proposed that they were necessary for biosynthesis of the cytochrome bd...; Region: ABCC_cytochrome_bd; cd03247
374930003472	Walker A/P-loop; other site
374930003473	ATP binding site [chemical binding]; other site
374930003474	Q-loop/lid; other site
374930003475	ABC transporter signature motif; other site
374930003476	Walker B; other site
374930003477	D-loop; other site
374930003478	H-loop/switch region; other site
374930003479	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster...; Region: Radical_SAM; cl14056
374930003480	anaerobic ribonucleoside-triphosphate reductase activating protein; Region: NrdG; TIGR02491
374930003481	Sodium:dicarboxylate symporter family; Region: SDF; cl00573
374930003482	LysE type translocator; Region: LysE; cl00565
374930003483	Phosphoribosyl transferase domain; Region: Pribosyltran; cl00309
374930003484	Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; cl00398
374930003485	Putative modulator of DNA gyrase; Region: PmbA_TldD; pfam01523
374930003486	Protein of unknown function (DUF615); Region: DUF615; cl01147
374930003487	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3117; cl01200
374930003488	Lipopolysaccharide-assembly, LptC-related; Region: LptC; pfam06835
374930003489	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1934
374930003490	OstA-like protein; Region: OstA; cl00844
374930003491	lipopolysaccharide ABC transporter ATP-binding protein; Provisional; Region: PRK10895
374930003492	The ABC transporters belonging to the YhbG family are similar to members of the Mj1267_LivG family, which is involved in the transport of branched-chain amino acids. The genes yhbG and yhbN are located in a single operon and may function together in...; Region: ABC_YhbG; cd03218
374930003493	Walker A/P-loop; other site
374930003494	ATP binding site [chemical binding]; other site
374930003495	Q-loop/lid; other site
374930003496	ABC transporter signature motif; other site
374930003497	Walker B; other site
374930003498	D-loop; other site
374930003499	H-loop/switch region; other site
374930003500	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
374930003501	active site
374930003502	phosphorylation site [posttranslational modification]
374930003503	P-loop ATPase protein family; Region: ATP_bind_2; cl10035
374930003504	bifunctional chorismate mutase/prephenate dehydratase; Provisional; Region: pheA; PRK10622
374930003505	Chorismate mutase type II; Region: CM_2; cl00693
374930003506	Prephenate dehydratase; Region: PDT; pfam00800
374930003507	C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905
374930003508	putative L-Phe binding site [chemical binding]; other site
374930003509	UDP-3-O-acyl-N-acetylglucosamine deacetylase [Cell envelope biogenesis, outer membrane]; Region: LpxC; cl00512
374930003510	UDP-3-O-acyl N-acetylglycosamine deacetylase; Region: LpxC; pfam03331
374930003511	FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes.  FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum...; Region: FtsZ_type1; cd02201
374930003512	nucleotide binding site [chemical binding]; other site
374930003513	SulA interaction site; other site
374930003514	potential frameshift: common BLAST hit: gi|16273068|ref|NP_439300.1| cell division protein [Haemophilus influenzae Rd KW20]
374930003515	POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478
374930003516	Cell division protein FtsQ; Region: FtsQ; pfam03799
374930003517	D-alanine--D-alanine ligase; Reviewed; Region: ddl; PRK01372
374930003518	D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820
374930003519	Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087
374930003520	UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421
374930003521	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
374930003522	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
374930003523	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
374930003524	undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726
374930003525	MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl...; Region: GT1_MurG; cd03785
374930003526	active site
374930003527	homodimer interface [polypeptide binding]; other site
374930003528	Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511
374930003529	UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK03806
374930003530	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
374930003531	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
374930003532	phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108
374930003533	Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of undecaprenyl-pyrophosphoryl-N-...; Region: GT_MraY; cd06852
374930003534	Mg++ binding site [ion binding]; other site
374930003535	putative catalytic motif [active]
374930003536	putative substrate binding site [chemical binding]; other site
374930003537	UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase; Reviewed; Region: murF; PRK10773
374930003538	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
374930003539	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
374930003540	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
374930003541	UDP-N-acetylmuramyl-tripeptide synthetase; Region: murE; TIGR01085
374930003542	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
374930003543	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
374930003544	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
374930003545	peptidoglycan synthase FtsI; Provisional; Region: PRK15105
374930003546	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
374930003547	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01039
374930003548	Septum formation initiator; Region: DivIC; cl11433
374930003549	Predicted S-adenosylmethionine-dependent methyltransferase involved in cell envelope biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG0275
374930003550	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011
374930003551	mraZ protein; Region: TIGR00242
374930003552	MraZ protein; Region: MraZ; pfam02381
374930003553	MraZ protein; Region: MraZ; pfam02381
374930003554	Carbon starvation protein CstA; Region: CstA; cl00856
374930003555	Uncharacterised protein family UPF0547; Region: UPF0547; pfam10571
374930003556	transaldolase-like protein; Provisional; Region: PTZ00411
374930003557	Transaldolases including both TalA and TalB; Region: Transaldolase_TalAB; cd00957
374930003558	active site
374930003559	dimer interface [polypeptide binding]; other site
374930003560	catalytic residue [active]
374930003561	oligopeptide ABC transporter substrate-binding protein OppA; Provisional; Region: PRK15104
374930003562	The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504
374930003563	peptide binding site [polypeptide binding]; other site
374930003564	oligopeptide transporter permease; Reviewed; Region: oppB; PRK09471
374930003565	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261
374930003566	dimer interface [polypeptide binding]; other site
374930003567	conserved gate region; other site
374930003568	putative PBP binding loops; other site
374930003569	ABC-ATPase subunit interface; other site
374930003570	oligopeptide ABC transporter permease OppC; Provisional; Region: PRK15406
374930003571	N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911
374930003572	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261
374930003573	dimer interface [polypeptide binding]; other site
374930003574	conserved gate region; other site
374930003575	ABC-ATPase subunit interface; other site
374930003576	oligopeptide transporter ATP-binding component; Provisional; Region: oppD; PRK09473
374930003577	The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE).  The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257
374930003578	Walker A/P-loop; other site
374930003579	ATP binding site [chemical binding]; other site
374930003580	Q-loop/lid; other site
374930003581	ABC transporter signature motif; other site
374930003582	Walker B; other site
374930003583	D-loop; other site
374930003584	H-loop/switch region; other site
374930003585	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
374930003586	oligopeptide ABC transporter ATP-binding protein OppF; Provisional; Region: PRK15079
374930003587	The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE).  The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257
374930003588	Walker A/P-loop; other site
374930003589	ATP binding site [chemical binding]; other site
374930003590	Q-loop/lid; other site
374930003591	ABC transporter signature motif; other site
374930003592	Walker B; other site
374930003593	D-loop; other site
374930003594	H-loop/switch region; other site
374930003595	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
374930003596	potential frameshift: common BLAST hit: gi|68249670|ref|YP_248782.1| D-xylose transport permease protein [Haemophilus influenzae]
374930003597	The YihA (EngB) subfamily.  This subfamily of GTPases is typified by the E. coli YihA, an essential protein involved in cell division control.  YihA and its orthologs are small proteins that typically contain less than 200 amino acid residues and...; Region: YihA_EngB; cd01876
374930003598	G1 box; other site
374930003599	GTP/Mg2+ binding site [chemical binding]; other site
374930003600	Switch I region; other site
374930003601	G2 box; other site
374930003602	G3 box; other site
374930003603	Switch II region; other site
374930003604	G4 box; other site
374930003605	G5 box; other site
374930003606	Mg chelatase-related protein; Region: TIGR00368
374930003607	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009
374930003608	Walker A motif; other site
374930003609	ATP binding site [chemical binding]; other site
374930003610	Walker B motif; other site
374930003611	arginine finger; other site
374930003612	2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959
374930003613	intersubunit interface [polypeptide binding]; other site
374930003614	active site
374930003615	catalytic residue [active]
374930003616	TlpA-like family, suppressor for copper sensitivity D protein (ScsD) and actinobacterial DsbE homolog subfamily; composed of ScsD, the DsbE homolog of Mycobacterium tuberculosis (MtbDsbE) and similar proteins, all containing a redox-active CXXC motif...; Region: TlpA_like_ScsD_MtbDsbE; cd03011
374930003617	catalytic residues [active]
374930003618	ADP-L-glycero-D-mannoheptose 6-epimerase (GME), extended (e) SDRs; Region: ADP_GME_SDR_e; cd05248
374930003619	ADP-L-glycero-D-mannoheptose-6-epimerase; Provisional; Region: rfaD; PRK11150
374930003620	NADP binding site [chemical binding]; other site
374930003621	homopentamer interface [polypeptide binding]; other site
374930003622	substrate binding site [chemical binding]; other site
374930003623	active site
374930003624	FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121
374930003625	FGGY family of carbohydrate kinases, C-terminal domain; Region: FGGY_C; pfam02782
374930003626	FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121
374930003627	L-rhamnose isomerase (RhaA); Region: RhaA; cl09945
374930003628	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879
374930003629	Periplasmic xylose-binding component of the ABC-type transport systems that belong to a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_xylose_binding; cd01538
374930003630	putative ligand binding site [chemical binding]; other site
374930003631	potential frameshift: common BLAST hit: gi|16273035|ref|NP_439267.1| D-xylose ABC transporter ATP-binding protein [Haemophilus]
374930003632	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
374930003633	TM-ABC transporter signature motif; other site
374930003634	tyrosine aminotransferase, eukaryotic; Region: tyr_amTase_E; TIGR01264
374930003635	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
374930003636	pyridoxal 5'-phosphate binding site [chemical binding]; other site
374930003637	homodimer interface [polypeptide binding]; other site
374930003638	catalytic residue [active]
374930003639	Na+/H+ antiporter NhaC; Region: antiport_nhaC; TIGR00931
374930003640	Anion permease ArsB/NhaD.  These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life.  A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl09110
374930003641	Anion permease ArsB/NhaD.  These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life.  A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl09110
374930003642	Ligand-binding domain of DNA transcription repressor specific for xylose (XylR); Region: PBP1_XylR; cd01543
374930003643	putative dimerization interface [polypeptide binding]; other site
374930003644	putative ligand binding site [chemical binding]; other site
374930003645	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
374930003646	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
374930003647	ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859
374930003648	Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789
374930003649	putative active site [active]
374930003650	benzoate transport; Region: 2A0115; TIGR00895
374930003651	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
374930003652	putative substrate translocation pore; other site
374930003653	cysteine synthases; Region: cysKM; TIGR01136
374930003654	CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine...; Region: CBS_like; cd01561
374930003655	dimer interface [polypeptide binding]; other site
374930003656	pyridoxal 5'-phosphate binding site [chemical binding]; other site
374930003657	catalytic residue [active]
374930003658	Etoposide-induced protein 2.4 (EI24); Region: EI24; cl01126
374930003659	cell division protein ZipA; Provisional; Region: PRK01741
374930003660	ZipA C-terminal domain. ZipA, a membrane-anchored protein, is one of at least nine essential gene products necessary for assembly of the septal ring which mediates cell division in E.coli. ZipA and FtsA directly bind FtsZ, a homolog of eukaryotic...; Region: ZipA; cd00231
374930003661	FtsZ protein binding site [polypeptide binding]; other site
374930003662	NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956
374930003663	NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114
374930003664	nucleotide binding pocket [chemical binding]; other site
374930003665	K-X-D-G motif; other site
374930003666	catalytic site [active]
374930003667	NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120
374930003668	NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119
374930003669	Helix-hairpin-helix motif; Region: HHH_2; pfam12826
374930003670	Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo/...; Region: BRCT; cd00027
374930003671	Dimer interface [polypeptide binding]; other site
374930003672	BRCT sequence motif; other site
374930003673	Prokaryotic membrane lipoprotein lipid attachment site; Region: LPAM_1; pfam08139
374930003674	Heme-copper oxidase subunit III.  Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which couple the reduction of molecular oxygen to water to, proton pumping across the membrane. The...; Region: Heme_Cu_Oxidase_III_like; cl00211
374930003675	Cytochrome c biogenesis factor [Posttranslational modification, protein turnover, chaperones]; Region: COG4235
374930003676	cytochrome c-type biogenesis protein CcmI; Region: cytochro_ccmI; TIGR03142
374930003677	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189
374930003678	binding surface
374930003679	TPR motif; other site
374930003680	Cytochrome C biogenesis protein; Region: CcmH; cl01179
374930003681	TlpA-like family, DsbE (also known as CcmG and CycY) subfamily; DsbE is a membrane-anchored, periplasmic TRX-like reductase containing a CXXC motif that specifically donates reducing equivalents to apocytochrome c via CcmH, another cytochrome c...; Region: TlpA_like_DsbE; cd03010
374930003682	catalytic residues [active]
374930003683	central insert; other site
374930003684	Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504
374930003685	CcmE; Region: CcmE; cl00994
374930003686	Heme exporter protein D (CcmD); Region: CcmD; cl11475
374930003687	Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504
374930003688	CcmB protein; Region: CcmB; cl01016
374930003689	cytochrome c biogenesis protein CcmA; Provisional; Region: PRK13538
374930003690	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099
374930003691	Walker A/P-loop; other site
374930003692	ATP binding site [chemical binding]; other site
374930003693	Q-loop/lid; other site
374930003694	ABC transporter signature motif; other site
374930003695	Walker B; other site
374930003696	D-loop; other site
374930003697	H-loop/switch region; other site
374930003698	superoxide dismutase; Provisional; Region: PRK10925
374930003699	Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081
374930003700	Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777
374930003701	putative ABC transporter ATP-binding protein YrbF; Provisional; Region: PRK11831
374930003702	ABC (ATP-binding cassette) transport system involved in resistant to organic solvents; ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars, ions, peptides, and more complex...; Region: ABC_Org_Solvent_Resistant; cd03261
374930003703	Walker A/P-loop; other site
374930003704	ATP binding site [chemical binding]; other site
374930003705	Q-loop/lid; other site
374930003706	ABC transporter signature motif; other site
374930003707	Walker B; other site
374930003708	D-loop; other site
374930003709	H-loop/switch region; other site
374930003710	Domain of unknown function DUF140; Region: DUF140; cl00510
374930003711	ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463
374930003712	mce related protein; Region: MCE; cl03606
374930003713	ABC-type transport system involved in resistance to organic solvents, auxiliary component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2D; cl01074
374930003714	Toluene tolerance, Ttg2; Region: Tol_Tol_Ttg2; pfam05494
374930003715	Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043
374930003716	anti sigma factor interaction site; other site
374930003717	regulatory phosphorylation site [posttranslational modification]; other site
374930003718	BolA-like protein; Region: BolA; cl00386
374930003719	UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Validated; Region: PRK09369
374930003720	UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555
374930003721	hinge; other site
374930003722	active site
374930003723	Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062
374930003724	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and...; Region: PBPb; cd00134
374930003725	substrate binding pocket [chemical binding]; other site
374930003726	membrane-bound complex binding site; other site
374930003727	hinge residues; other site
374930003728	potential frameshift: common BLAST hit: gi|16273641|ref|NP_439236.1| ABC-type amino acid transport system permease component
374930003729	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
374930003730	HisP and GlnQ are the ATP-binding components of the bacterial periplasmic histidine and glutamine permeases, repectively.  Histidine permease is a multisubunit complex containing the HisQ and HisM integral membrane subunits and two copies of HisP; Region: ABC_HisP_GlnQ_permeases; cd03262
374930003731	Walker A/P-loop; other site
374930003732	ATP binding site [chemical binding]; other site
374930003733	Q-loop/lid; other site
374930003734	ABC transporter signature motif; other site
374930003735	Walker B; other site
374930003736	D-loop; other site
374930003737	H-loop/switch region; other site
374930003738	Nicotinamide mononucleotide transporter; Region: NMN_transporter; cl01256
374930003739	CTP synthetase; Validated; Region: pyrG; PRK05380
374930003740	CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer...; Region: CTGs; cd03113
374930003741	Catalytic site [active]
374930003742	Active site [active]
374930003743	UTP binding site [chemical binding]; other site
374930003744	Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746
374930003745	active site
374930003746	putative oxyanion hole; other site
374930003747	catalytic triad [active]
374930003748	Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; cl00562
374930003749	cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219
374930003750	Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322
374930003751	Protein of unknown function (DUF441); Region: DUF441; cl01041
374930003752	Protein of unknown function (DUF423); Region: DUF423; cl01008
374930003753	ATP-dependent RNA helicase HrpA; Provisional; Region: PRK11131
374930003754	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
374930003755	ATP binding site [chemical binding]; other site
374930003756	putative Mg++ binding site [ion binding]; other site
374930003757	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
374930003758	nucleotide binding region [chemical binding]; other site
374930003759	ATP-binding site [chemical binding]; other site
374930003760	Helicase associated domain (HA2); Region: HA2; cl04503
374930003761	Oligonucleotide/oligosaccharide-binding (OB)-fold; Region: OB_NTP_bind; pfam07717
374930003762	Domain of unknown function (DUF3418); Region: DUF3418; pfam11898
374930003763	Formate-dependent nitrite reductase, periplasmic cytochrome c552 subunit [Inorganic ion transport and metabolism]; Region: NrfA; COG3303
374930003764	cytochrome c nitrite reductase subunit c552; Provisional; Region: nrfA; cl10556
374930003765	cytochrome c nitrite reductase pentaheme subunit; Provisional; Region: PRK11659
374930003766	cytochrome c nitrite reductase, Fe-S protein; Region: cyt_nit_nrfC; TIGR03149
374930003767	potential frameshift: common BLAST hit: gi|68249624|ref|YP_248736.1| NrfD, formate-dependent nitrite reductase, membrane component
374930003768	UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control...; Region: AAK_UMPK-PyrH-Ec; cd04254
374930003769	putative nucleotide binding site [chemical binding]; other site
374930003770	uridine monophosphate binding site [chemical binding]; other site
374930003771	homohexameric interface [polypeptide binding]; other site
374930003772	Sulfatase; Region: Sulfatase; cl10460
374930003773	FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288
374930003774	UDP-N-acetylglucosamine acyltransferase; Provisional; Region: PRK05289
374930003775	UDP-N-acetylglucosamine O-acyltransferase (UDP-GlcNAc acyltransferase): Proteins in this family catalyze the transfer of (R)-3-hydroxymyristic acid from its acyl carrier protein thioester to UDP-GlcNAc. It is the first enzyme in the lipid A...; Region: LbH_UDP-GlcNAc_AT; cd03351
374930003776	active site
374930003777	lipid-A-disaccharide synthase; Reviewed; Region: lpxB; PRK00025
374930003778	ipid-A-disaccharide synthase; Provisional; Region: PRK14089
374930003779	bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182
374930003780	RNA/DNA hybrid binding site [nucleotide binding]; other site
374930003781	active site
374930003782	Type III restriction/modification enzyme methylation subunit; Region: TypeIII_RM_meth; pfam12564
374930003783	Adenine specific DNA methylase Mod [DNA replication, recombination, and repair]; Region: COG2189
374930003784	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011
374930003785	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011
374930003786	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011
374930003787	potential frameshift: common BLAST hit: gi|59801067|ref|YP_207779.1| RmsR [Neisseria gonorrhoeae FA 1090]
374930003788	Carboxymuconolactone decarboxylase family; Region: CMD; cl00460
374930003789	Cupin domain; Region: Cupin_2; cl09118
374930003790	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
374930003791	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
374930003792	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
374930003793	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
374930003794	ABC transporter transmembrane region; Region: ABC_membrane; cl00549
374930003795	MsbA is an essential ABC transporter, closely related to eukaryotic MDR proteins.  ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars, ions, peptides, and more complex organic...; Region: ABCC_MsbA; cd03251
374930003796	Walker A/P-loop; other site
374930003797	ATP binding site [chemical binding]; other site
374930003798	Q-loop/lid; other site
374930003799	ABC transporter signature motif; other site
374930003800	Walker B; other site
374930003801	D-loop; other site
374930003802	H-loop/switch region; other site
374930003803	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
374930003804	metal-binding site [ion binding]
374930003805	Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305
374930003806	Transglutaminase-like superfamily; Region: Transglut_core; cl10469
374930003807	DmsA/YnfE family; Region: dmsA_ynfE; TIGR02166
374930003808	Tat (twin-arginine translocation) pathway signal sequence; Region: TAT_signal_seq; TIGR01409
374930003809	This CD (MopB_DmsA-EC) includes the DmsA enzyme of the dmsABC operon encoding the anaerobic dimethylsulfoxide reductase (DMSOR) of Escherichia coli and other related DMSOR-like enzymes. Unlike other DMSOR-like enzymes, this group has a  predicted N-...; Region: MopB_DmsA-EC; cd02770
374930003810	putative [Fe4-S4] binding site [ion binding]; other site
374930003811	putative molybdopterin cofactor binding site [chemical binding]; other site
374930003812	Molybdopterin-Binding, C-terminal (MopB_CT) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum-; Region: MopB_CT; cl09929
374930003813	molybdopterin cofactor binding site; other site
374930003814	potential frameshift: common BLAST hit: gi|68249608|ref|YP_248720.1| anaerobic dimethyl sulfoxide reductase chain B [Haemophilus]
374930003815	DMSO reductase anchor subunit (DmsC); Region: DmsC; cl04869
374930003816	Nitrate reductase delta subunit; Region: Nitrate_red_del; cl00958
374930003817	ferredoxin-type protein NapF; Region: napF; TIGR00402
374930003818	RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409
374930003819	MinD superfamily P-loop ATPase containing an inserted ferredoxin domain [Energy production and conversion]; Region: COG1149
374930003820	Glutamine amidotransferases class-II (Gn-AT)_YafJ-type.  YafJ is a glutamine amidotransferase-like protein of unknown function found in prokaryotes, eukaryotes and archaea.  YafJ has a conserved structural fold similar to those of other class II...; Region: YafJ; cd01908
374930003821	putative active site [active]
374930003822	putative dimer interface [polypeptide binding]; other site
374930003823	YGGT family; Region: YGGT; cl00508
374930003824	YGGT family; Region: YGGT; cl00508
374930003825	Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598
374930003826	magnesium/nickel/cobalt transporter CorA; Provisional; Region: PRK11085; cl00459
374930003827	Protein of unknown function (DUF520); Region: DUF520; cl00723
374930003828	phosphoserine phosphatase; Provisional; Region: serB; PRK11133
374930003829	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cd01427
374930003830	motif II; other site
374930003831	transketolase; Reviewed; Region: PRK12753
374930003832	Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012
374930003833	TPP-binding site [chemical binding]; other site
374930003834	dimer interface [polypeptide binding]; other site
374930003835	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
374930003836	PYR/PP interface [polypeptide binding]; other site
374930003837	dimer interface [polypeptide binding]; other site
374930003838	TPP binding site [chemical binding]; other site
374930003839	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
374930003840	biotin synthetase; Region: bioB; TIGR00433
374930003841	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster...; Region: Radical_SAM; cd01335
374930003842	FeS/SAM binding site; other site
374930003843	Biotin and Thiamin Synthesis associated domain; Region: BATS; cl06149
374930003844	potential frameshift: common BLAST hit: gi|68249594|ref|YP_248706.1| thiamine transport ATP-binding protein [Haemophilus influenzae]
374930003845	thiamine ABC transporter, permease protein; Region: thiP; TIGR01253
374930003846	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261
374930003847	dimer interface [polypeptide binding]; other site
374930003848	conserved gate region; other site
374930003849	putative PBP binding loops; other site
374930003850	ABC-ATPase subunit interface; other site
374930003851	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261
374930003852	dimer interface [polypeptide binding]; other site
374930003853	conserved gate region; other site
374930003854	putative PBP binding loops; other site
374930003855	ABC-ATPase subunit interface; other site
374930003856	ABC-type thiamine transport system, periplasmic component [Coenzyme metabolism]; Region: TbpA; COG4143
374930003857	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
374930003858	competence protein ComEA helix-hairpin-helix repeat region; Region: TIGR00426
374930003859	LytB protein; Region: LYTB; cl00507
374930003860	(E)-4-hydroxy-3-methyl-but-2-enyl pyrophosphate reductase (IPP and DMAPP forming); Region: ispH_lytB; TIGR00216
374930003861	potential frameshift: common BLAST hit: gi|16272941|ref|NP_439167.1| signal peptidase II [Haemophilus influenzae Rd KW20]
374930003862	potential frameshift: common BLAST hit: gi|68249588|ref|YP_248700.1| predicted PE--lipooligosaccharide phosphorylethanolamine
374930003863	periplasmic folding chaperone; Provisional; Region: PRK10788
374930003864	PPIC-type PPIASE domain; Region: Rotamase; cl08278
374930003865	tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291
374930003866	GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396
374930003867	TrmE (MnmE, ThdF, MSS1) is a 3-domain protein found in bacteria and eukaryotes.  It controls modification of the uridine at the wobble position (U34) of tRNAs that read codons ending with A or G in the mixed codon family boxes.  TrmE contains a GTPase...; Region: trmE; cd04164
374930003868	G1 box; other site
374930003869	GTP/Mg2+ binding site [chemical binding]; other site
374930003870	Switch I region; other site
374930003871	G2 box; other site
374930003872	Switch II region; other site
374930003873	G3 box; other site
374930003874	G4 box; other site
374930003875	G5 box; other site
374930003876	Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631
374930003877	membrane protein insertase; Provisional; Region: PRK01318
374930003878	60Kd inner membrane protein; Region: 60KD_IMP; cl00489
374930003879	Ribonuclease P; Region: Ribonuclease_P; cl00457
374930003880	Domain of unknown function DUF37; Region: DUF37; cl00506
374930003881	Ribosomal protein L34; Region: Ribosomal_L34; cl00370
374930003882	Protein of unknown function (DUF560); Region: DUF560; pfam04575
374930003883	Transferrin binding protein-like solute binding protein; Region: Lipoprotein_5; pfam01298
374930003884	TonB-dependent lactoferrin and transferrin receptors; Region: TonB-tbp-lbp; TIGR01776
374930003885	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16...; Region: OM_channels; cl00284
374930003886	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
374930003887	chromosomal replication initiation protein; Reviewed; Region: dnaA; PRK00149
374930003888	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009
374930003889	Walker A motif; other site
374930003890	ATP binding site [chemical binding]; other site
374930003891	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099
374930003892	Walker B motif; other site
374930003893	arginine finger; other site
374930003894	C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571
374930003895	DnaA box-binding interface [nucleotide binding]; other site
374930003896	DNA polymerase III subunit beta; Validated; Region: PRK05643
374930003897	Beta clamp domain.  The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria.  The beta-clamp is structurally similar to the...; Region: beta_clamp; cd00140
374930003898	putative DNA binding surface [nucleotide binding]; other site
374930003899	dimer interface [polypeptide binding]; other site
374930003900	beta-clamp/clamp loader binding surface; other site
374930003901	beta-clamp/translesion DNA polymerase binding surface; other site
374930003902	recombination protein F; Reviewed; Region: recF; PRK00064
374930003903	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099
374930003904	Walker A/P-loop; other site
374930003905	ATP binding site [chemical binding]; other site
374930003906	Q-loop/lid; other site
374930003907	ABC transporter signature motif; other site
374930003908	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099
374930003909	ABC transporter signature motif; other site
374930003910	Walker B; other site
374930003911	D-loop; other site
374930003912	Immunoglobulin A1 protease; Region: Peptidase_S6; pfam02395
374930003913	Pertactin-like passenger domains (virulence factors), C-terminal, subgroup 1, of autotransporter proteins of the type V secretion system of Gram-negative bacteria. This subgroup includes the passenger domains of Neisseria and Haemophilus IgA1 proteases...; Region: PL1_Passenger_AT; cd01343
374930003914	Sporulation related domain; Region: SPOR; cl10051
374930003915	Flagellar hook-length control protein FliK; Region: Flg_hook; cl14669
374930003916	Autotransporter beta-domain; Region: Autotransporter; cl02365
374930003917	Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate 3-...; Region: IPMI_Swivel; cd01577
374930003918	substrate binding site [chemical binding]; other site
374930003919	3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402
374930003920	3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583
374930003921	substrate binding site [chemical binding]; other site
374930003922	ligand binding site [chemical binding]; other site
374930003923	Isocitrate/isopropylmalate dehydrogenase; Region: Iso_dh; cl00445
374930003924	isocitrate dehydrogenase; Validated; Region: PRK06451
374930003925	2-isopropylmalate synthase; Validated; Region: PRK00915
374930003926	2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940
374930003927	active site
374930003928	catalytic residues [active]
374930003929	metal binding site [ion binding]; metal-binding site
374930003930	LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; pfam08502
374930003931	Predicted Rossmann fold nucleotide-binding protein involved in DNA uptake [DNA replication, recombination, and repair / Intracellular trafficking and secretion]; Region: Smf; COG0758
374930003932	DNA recombination-mediator protein A; Region: DNA_processg_A; cl00695
374930003933	Protein of unknown function (DUF328); Region: DUF328; cl01143
374930003934	6-phosphofructokinase; Provisional; Region: PRK03202
374930003935	Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to a subfamily of the PFKA family (cd00363) and include bacterial ATP-dependent...; Region: Bacterial_PFK; cd00763
374930003936	active site
374930003937	ADP/pyrophosphate binding site [chemical binding]; other site
374930003938	dimerization interface [polypeptide binding]; other site
374930003939	allosteric effector site; other site
374930003940	fructose-1,6-bisphosphate binding site; other site
374930003941	Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294
374930003942	SmpB-tmRNA interface; other site
374930003943	Bacterial regulatory protein, Fis family; Region: HTH_8; cl01091
374930003944	putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737
374930003945	Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and...; Region: DUS_like_FMN; cd02801
374930003946	FMN binding site [chemical binding]; other site
374930003947	active site
374930003948	catalytic residues [active]
374930003949	substrate binding site [chemical binding]; other site
374930003950	ribosomal protein L11 methyltransferase; Region: prmA; TIGR00406
374930003951	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011
374930003952	Fic/DOC family; Region: Fic; cl00960
374930003953	EamA-like transporter family; Region: EamA; cl01037
374930003954	Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950
374930003955	EamA-like transporter family; Region: EamA; cl01037
374930003956	Sodium:solute symporter family; Region: SSF; cl00456
374930003957	Protein of unknown function (DUF997); Region: DUF997; cl01614
374930003958	acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591
374930003959	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
374930003960	Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087
374930003961	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; cl08365
374930003962	acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302
374930003963	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase...; Region: biotinyl_domain; cd06850
374930003964	carboxyltransferase (CT) interaction site; other site
374930003965	biotinylation site [posttranslational modification]; other site
374930003966	Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466
374930003967	active site
374930003968	trimer interface [polypeptide binding]; other site
374930003969	dimer interface [polypeptide binding]; other site
374930003970	O-succinylbenzoate synthase; Provisional; Region: PRK05105
374930003971	o-Succinylbenzoate synthase (OSBS) catalyzes the conversion of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC) to 4-(2'-carboxyphenyl)-4-oxobutyrate (o-succinylbenzoate or OSB), a reaction in the menaquinone biosynthetic pathway...; Region: OSBS; cd03320
374930003972	active site
374930003973	dihydroxynaphthoic acid synthetase; Validated; Region: PRK07396
374930003974	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase...; Region: crotonase-like; cd06558
374930003975	substrate binding site [chemical binding]; other site
374930003976	oxyanion hole (OAH) forming residues; other site
374930003977	trimer interface [polypeptide binding]; other site
374930003978	Ribosomal protein S20; Region: Ribosomal_S20p; cl00384
374930003979	potential frameshift: common BLAST hit: gi|68249552|ref|YP_248664.1| putative virulence factor MviN [Haemophilus influenzae 86-028NP]
374930003980	bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627
374930003981	FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064
374930003982	active site
374930003983	Riboflavin kinase; Region: Flavokinase; pfam01687
374930003984	isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743
374930003985	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
374930003986	active site
374930003987	HIGH motif; other site
374930003988	nucleotide binding site [chemical binding]; other site
374930003989	catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818
374930003990	active site
374930003991	KMSKS motif; other site
374930003992	Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960
374930003993	tRNA binding surface [nucleotide binding]; other site
374930003994	anticodon binding site; other site
374930003995	Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827
374930003996	Protein Kinase C Interacting protein related (PKCI): PKCI and related proteins belong to the ubiquitous HIT family of hydrolases that act on alpha-phosphates of ribonucleotides. The members of this subgroup have a conserved HxHxHxx motif (x is a...; Region: PKCI_related; cd01276
374930003997	nucleotide binding site/active site [active]
374930003998	HIT family signature motif; other site
374930003999	catalytic residue [active]
374930004000	Predicted periplasmic lipoprotein [General function prediction only]; Region: COG5633
374930004001	Putative periplasmic lipoprotein; Region: DUF1425; cd09030
374930004002	putative dimer interface [polypeptide binding]; other site
374930004003	Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971
374930004004	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011
374930004005	23S rRNA methyluridine methyltransferase; Reviewed; Region: rumB; PRK03522
374930004006	DNA-binding transcriptional dual regulator Crp; Provisional; Region: PRK11753
374930004007	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
374930004008	ligand binding site [chemical binding]; other site
374930004009	flexible hinge region; other site
374930004010	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092
374930004011	putative switch regulator; other site
374930004012	non-specific DNA interactions [nucleotide binding]; other site
374930004013	DNA binding site [nucleotide binding]
374930004014	sequence specific DNA binding site [nucleotide binding]; other site
374930004015	putative cAMP binding site [chemical binding]; other site
374930004016	Uncharacterised protein family (UPF0270); Region: UPF0270; cl01180
374930004017	division inhibitor protein; Provisional; Region: slmA; PRK09480
374930004018	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
374930004019	Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557
374930004020	trimer interface [polypeptide binding]; other site
374930004021	active site
374930004022	bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579
374930004023	Flavoprotein; Region: Flavoprotein; cl08021
374930004024	DNA / pantothenate metabolism flavoprotein; Region: DFP; cl04410
374930004025	hypothetical protein; Reviewed; Region: PRK00024
374930004026	Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071
374930004027	MPN+ (JAMM) motif; other site
374930004028	Zinc-binding site [ion binding]; other site
374930004029	Ribosomal L28 family; Region: Ribosomal_L28; cl00367
374930004030	Ribosomal protein L33; Region: Ribosomal_L33; cl00383
374930004031	diaminobutyrate--2-oxoglutarate aminotransferase; Provisional; Region: PRK06931
374930004032	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase...; Region: OAT_like; cd00610
374930004033	inhibitor-cofactor binding pocket; inhibition site
374930004034	pyridoxal 5'-phosphate binding site [chemical binding]; other site
374930004035	catalytic residue [active]
374930004036	Virulence-associated protein and related proteins [Function unknown]; Region: VagC; COG4456
374930004037	PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881
374930004038	oligomeric interface; other site
374930004039	putative active site [active]
374930004040	homodimer interface [polypeptide binding]; other site
374930004041	Glutamate decarboxylase and related PLP-dependent proteins [Amino acid transport and metabolism]; Region: GadB; COG0076
374930004042	DOPA decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to DOPA/tyrosine decarboxylase (DDC), histidine decarboxylase (HDC), and...; Region: DOPA_deC_like; cd06450
374930004043	pyridoxal 5'-phosphate binding site [chemical binding]; other site
374930004044	catalytic residue [active]
374930004045	formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103
374930004046	N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966
374930004047	DNA binding site [nucleotide binding]
374930004048	catalytic residue [active]
374930004049	H2TH interface [polypeptide binding]; other site
374930004050	putative catalytic residues [active]
374930004051	turnover-facilitating residue; other site
374930004052	intercalation triad [nucleotide binding]; other site
374930004053	8OG recognition residue [nucleotide binding]; other site
374930004054	putative reading head residues; other site
374930004055	Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831
374930004056	Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827
374930004057	periplasmic serine pepetdase DegS; Region: protease_degS; TIGR02038
374930004058	Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic...; Region: Tryp_SPc; cl00149
374930004059	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind C-...; Region: PDZ_serine_protease; cd00987
374930004060	riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326
374930004061	Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284
374930004062	catalytic motif [active]
374930004063	Zn binding site [ion binding]; other site
374930004064	Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5,10-...; Region: DHFR; cl00161
374930004065	transcriptional regulator NrdR; Region: TIGR00244
374930004066	ATP cone domain; Region: ATP-cone; pfam03477
374930004067	Exonuclease V gamma subunit [DNA replication, recombination, and repair]; Region: RecC; COG1330
374930004068	exonuclease V subunit gamma; Provisional; Region: recC; PRK11069
374930004069	Protein of unknown function (DUF2572); Region: DUF2572; pfam10833
374930004070	Type II secretory pathway, component PulJ [Intracellular trafficking and secretion]; Region: PulJ; COG4795
374930004071	Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulG; COG2165
374930004072	Prokaryotic N-terminal methylation motif; Region: N_methyl; cl06830
374930004073	IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639
374930004074	active site
374930004075	dimerization interface [polypeptide binding]; other site
374930004076	Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504
374930004077	TlpA-like family, DsbE (also known as CcmG and CycY) subfamily; DsbE is a membrane-anchored, periplasmic TRX-like reductase containing a CXXC motif that specifically donates reducing equivalents to apocytochrome c via CcmH, another cytochrome c...; Region: TlpA_like_DsbE; cd03010
374930004078	catalytic residues [active]
374930004079	central insert; other site
374930004080	Cytochrome C biogenesis protein; Region: CcmH; cl01179
374930004081	Cytochrome c biogenesis factor [Posttranslational modification, protein turnover, chaperones]; Region: COG4235
374930004082	enolase; Provisional; Region: eno; PRK00077
374930004083	Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313
374930004084	dimer interface [polypeptide binding]; other site
374930004085	metal binding site [ion binding]; metal-binding site
374930004086	substrate binding pocket [chemical binding]; other site
374930004087	Glutathionylspermidine synthase; Region: GSP_synth; cl00503
374930004088	Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753
374930004089	Clade 3 of the heme-binding enzyme catalase; Region: catalase_clade_3; cd08156
374930004090	tetramer interface [polypeptide binding]; other site
374930004091	heme binding pocket [chemical binding]; other site
374930004092	NADPH binding site [chemical binding]; other site
374930004093	glycyl-tRNA synthetase, tetrameric type, alpha subunit; Region: glyQ; TIGR00388
374930004094	Class II Glycyl-tRNA synthetase (GlyRS) alpha subunit core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes and in arabidopsis. It is responsible for the...; Region: GlyRS_alpha_core; cd00733
374930004095	dimer interface [polypeptide binding]; other site
374930004096	motif 1; other site
374930004097	active site
374930004098	motif 2; other site
374930004099	motif 3; other site
374930004100	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
374930004101	Domain of unknown function, appears to be related to a diverse group of endonucleases; Region: Endonuclease_DUF559; cd01038
374930004102	putative active site [active]
374930004103	glycyl-tRNA synthetase, tetrameric type, beta subunit; Region: glyS; TIGR00211
374930004104	Glycyl-tRNA synthetase beta subunit; Region: tRNA_synt_2f; pfam02092
374930004105	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
374930004106	Phage major capsid protein, P2 family; Region: Phage_cap_P2; cl04947
374930004107	Phd_YefM; Region: PhdYeFM; cl09153
374930004108	Plasmid stabilisation system protein; Region: Plasmid_stabil; cl11422
374930004109	DNA polymerase III subunit delta; Reviewed; Region: holA; PRK05574
374930004110	DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144
374930004111	Lipopolysaccharide-assembly; Region: LptE; cl01125
374930004112	leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390
374930004113	catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812
374930004114	HIGH motif; other site
374930004115	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
374930004116	active site
374930004117	KMSKS motif; other site
374930004118	Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958
374930004119	tRNA binding surface [nucleotide binding]; other site
374930004120	Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475
374930004121	catalytic residue [active]
374930004122	putative FPP diphosphate  binding site; other site
374930004123	putative FPP binding hydrophobic cleft; other site
374930004124	dimer interface [polypeptide binding]; other site
374930004125	putative IPP diphosphate binding site; other site
374930004126	Cytidylyltransferase family; Region: CTP_transf_1; cl00347
374930004127	zinc metallopeptidase RseP; Provisional; Region: PRK10779
374930004128	RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163
374930004129	active site
374930004130	PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most...; Region: PDZ_metalloprotease; cd00989
374930004131	protein binding site [polypeptide binding]; other site
374930004132	PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most...; Region: PDZ_metalloprotease; cd00989
374930004133	protein binding site [polypeptide binding]; other site
374930004134	RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163
374930004135	putative substrate binding region [chemical binding]; other site
374930004136	outer membrane protein assembly factor YaeT; Provisional; Region: PRK11067
374930004137	Surface antigen variable number repeat; Region: Surf_Ag_VNR; cl10520
374930004138	Surface antigen variable number repeat; Region: Surf_Ag_VNR; cl10520
374930004139	Surface antigen variable number repeat; Region: Surf_Ag_VNR; cl10520
374930004140	Surface antigen variable number repeat; Region: Surf_Ag_VNR; cl10520
374930004141	Surface antigen; Region: Bac_surface_Ag; cl03097
374930004142	Outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: HlpA; COG2825
374930004143	Outer membrane protein (OmpH-like); Region: OmpH; cl08146
374930004144	UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Provisional; Region: lpxD; PRK00892
374930004145	UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase, LpxD; Region: LpxD; pfam04613
374930004146	UDP-3-O-acyl-glucosamine N-acyltransferase (LpxD): The enzyme catalyzes the transfer of 3-hydroxymyristic acid or 3-hydroxy-arachidic acid, depending on the organism, from the acyl carrier protein (ACP) to UDP-3-O-acyl-glucosamine to produce UDP-2,3-...; Region: LbH_LpxD; cd03352
374930004147	trimer interface [polypeptide binding]; other site
374930004148	active site
374930004149	UDP-GlcNAc binding site [chemical binding]; other site
374930004150	lipid binding site [chemical binding]; lipid-binding site
374930004151	elongation factor Ts; Provisional; Region: tsf; PRK09377
374930004152	Ubiquitin Associated domain. The UBA domain is a commonly occurring sequence motif in some members of the ubiquitination pathway, UV excision repair proteins, and certain protein kinases. Although its specific role is so far unknown, it has been...; Region: UBA; cl00153
374930004153	Elongation factor TS; Region: EF_TS; pfam00889
374930004154	Elongation factor TS; Region: EF_TS; pfam00889
374930004155	Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425
374930004156	rRNA interaction site [nucleotide binding]; other site
374930004157	S8 interaction site; other site
374930004158	putative laminin-1 binding site; other site
374930004159	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440
374930004160	SAM-dependent methyltransferases [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: SmtA; COG0500
374930004161	glutathione-regulated potassium-efflux system protein KefB; Provisional; Region: PRK03659
374930004162	Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482
374930004163	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
374930004164	preprotein translocase subunit SecA; Reviewed; Region: PRK12904
374930004165	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl14882
374930004166	SecA preprotein cross-linking domain; Region: SecA_PP_bind; pfam01043
374930004167	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
374930004168	nucleotide binding region [chemical binding]; other site
374930004169	ATP-binding site [chemical binding]; other site
374930004170	SEC-C motif; Region: SEC-C; cl12132
374930004171	Protein of unknown function (DUF2547); Region: DUF2547; pfam10818
374930004172	Protein of unknown function (DUF721); Region: DUF721; cl02324
374930004173	Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285
374930004174	nucleoside/Zn binding site; other site
374930004175	dimer interface [polypeptide binding]; other site
374930004176	catalytic motif [active]
374930004177	Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351
374930004178	dimerization interface [polypeptide binding]; other site
374930004179	active site
374930004180	Prolipoprotein diacylglyceryl transferase; Region: LGT; cl00478
374930004181	Predicted permeases [General function prediction only]; Region: COG0730; cl00498
374930004182	Diadenosine tetraphosphate (Ap4A) hydrolase is a member of the Nudix hydrolase superfamily. Members of this family are well represented in a variety of prokaryotic and eukaryotic organisms. Phylogenetic analysis reveals two distinct subgroups where...; Region: Ap4A_hydrolase_plant_like; cd03671
374930004183	putative active site [active]
374930004184	Ap4A binding site [chemical binding]; other site
374930004185	nudix motif; other site
374930004186	putative metal binding site [ion binding]; other site
374930004187	gamma-glutamyl kinase; Provisional; Region: PRK05429
374930004188	AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242
374930004189	nucleotide binding site [chemical binding]; other site
374930004190	homotetrameric interface [polypeptide binding]; other site
374930004191	putative phosphate binding site [ion binding]; other site
374930004192	putative allosteric binding site; other site
374930004193	PUA domain; Region: PUA; cl00607
374930004194	Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5,10-...; Region: DHFR; cd00209
374930004195	folate binding site [chemical binding]; other site
374930004196	NADP+ binding site [chemical binding]; other site
374930004197	efflux pump membrane protein (multidrug resistance protein A); Region: 8a0101; TIGR00998
374930004198	potential frameshift: common BLAST hit: gi|68249484|ref|YP_248596.1| multidrug resistance protein [Haemophilus influenzae 86-028NP]
374930004199	Cell division protein [Cell division and chromosome partitioning]; Region: FtsN; COG3087
374930004200	Sporulation related domain; Region: SPOR; cl10051
374930004201	multidrug efflux protein; Reviewed; Region: PRK09579
374930004202	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
374930004203	potential frameshift: common BLAST hit: gi|16272831|ref|NP_439054.1| transcriptional repressor [Haemophilus influenzae Rd KW20]
374930004204	similar to hypothetical protein; COG1309 Transcriptional regulator
374930004205	ATP-dependent RNA helicase RhlB; Provisional; Region: PRK04837
374930004206	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif (...; Region: DEADc; cd00268
374930004207	ATP binding site [chemical binding]; other site
374930004208	Mg++ binding site [ion binding]; other site
374930004209	motif III; other site
374930004210	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
374930004211	nucleotide binding region [chemical binding]; other site
374930004212	ATP-binding site [chemical binding]; other site
374930004213	Domain of unknown function (DUF329); Region: DUF329; cl01144
374930004214	Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237
374930004215	Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022
374930004216	CoA-binding site [chemical binding]; other site
374930004217	ATP-binding [chemical binding]; other site
374930004218	Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of...; Region: SHMT; cd00378
374930004219	dimer interface [polypeptide binding]; other site
374930004220	glycine-pyridoxal phosphate binding site [chemical binding]; other site
374930004221	active site
374930004222	folate binding site [chemical binding]; other site
374930004223	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
374930004224	phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885
374930004225	Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844
374930004226	Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087
374930004227	Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843
374930004228	bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881
374930004229	Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal  ATIC formylase domain that formylates 5-aminoimidazole-4-carboxamide-; Region: IMPCH; cd01421
374930004230	purine monophosphate binding site [chemical binding]; other site
374930004231	dimer interface [polypeptide binding]; other site
374930004232	putative catalytic residues [active]
374930004233	AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362
374930004234	AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362
374930004235	DoxX; Region: DoxX; cl00976
374930004236	thiol:disulfide interchange protein precursor; Provisional; Region: dipZ; PRK00293
374930004237	Disulphide bond corrector protein DsbC; Region: DsbC; pfam11412
374930004238	Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl00515
374930004239	DsbD gamma family; DsbD gamma is the C-terminal periplasmic domain of the bacterial protein DsbD. It contains a CXXC motif in a TRX fold and shuttles the reducing potential from the membrane domain (DsbD beta) to the N-terminal periplasmic domain (DsbD...; Region: DsbDgamma; cd02953
374930004240	DsbD alpha interface [polypeptide binding]; other site
374930004241	catalytic residues [active]
374930004242	two-component response regulator; Provisional; Region: PRK11173
374930004243	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156
374930004244	active site
374930004245	phosphorylation site [posttranslational modification]
374930004246	intermolecular recognition site; other site
374930004247	dimerization interface [polypeptide binding]; other site
374930004248	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase...; Region: trans_reg_C; cd00383
374930004249	DNA binding site [nucleotide binding]
374930004250	Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548
374930004251	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1636
374930004252	Uncharacterized BCR, COG1636; Region: DUF208; pfam02677
374930004253	octaprenyl diphosphate synthase; Provisional; Region: PRK10888
374930004254	Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685
374930004255	substrate binding pocket [chemical binding]; other site
374930004256	chain length determination region; other site
374930004257	substrate-Mg2+ binding site; other site
374930004258	catalytic residues [active]
374930004259	aspartate-rich region 1; other site
374930004260	active site lid residues [active]
374930004261	aspartate-rich region 2; other site
374930004262	Ribosomal prokaryotic L21 protein; Region: Ribosomal_L21p; cl00382
374930004263	Ribosomal L27 protein; Region: Ribosomal_L27; cl00359
374930004264	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
374930004265	EamA-like transporter family; Region: EamA; cl01037
374930004266	EamA-like transporter family; Region: EamA; cl01037
374930004267	GTPase CgtA; Reviewed; Region: obgE; PRK12298
374930004268	GTP1/OBG; Region: GTP1_OBG; pfam01018
374930004269	Obg subfamily.  The Obg nucleotide binding protein subfamily has been implicated in stress response, chromosome partitioning, replication initiation, mycelium development, and sporulation.  Obg proteins are among a large group of GTP binding proteins...; Region: Obg; cd01898
374930004270	G1 box; other site
374930004271	GTP/Mg2+ binding site [chemical binding]; other site
374930004272	Switch I region; other site
374930004273	G2 box; other site
374930004274	G3 box; other site
374930004275	Switch II region; other site
374930004276	G4 box; other site
374930004277	G5 box; other site
374930004278	Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413
374930004279	active site
374930004280	multimer interface [polypeptide binding]; other site
374930004281	aminopeptidase B; Provisional; Region: PRK05015
374930004282	Cytosol aminopeptidase family, N-terminal and catalytic domains.  Family M17 contains zinc- and manganese-dependent exopeptidases ( EC  3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein...; Region: Peptidase_M17; cd00433
374930004283	interface (dimer of trimers) [polypeptide binding]; other site
374930004284	Substrate-binding/catalytic site; other site
374930004285	Zn-binding sites [ion binding]; other site
374930004286	O-Antigen ligase; Region: Wzy_C; cl04850
374930004287	dTDP-glucose 4,6 dehydratase; Provisional; Region: PRK10084
374930004288	dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246
374930004289	NAD binding site [chemical binding]; other site
374930004290	substrate binding site [chemical binding]; other site
374930004291	homodimer interface [polypeptide binding]; other site
374930004292	active site
374930004293	undecaprenyl-phosphate galactose phosphotransferase; Provisional; Region: PRK15204
374930004294	Bacterial sugar transferase; Region: Bac_transf; cl00939
374930004295	Glycosyltransferase family 52; Region: Glyco_transf_52; pfam07922
374930004296	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
374930004297	active site
374930004298	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
374930004299	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
374930004300	active site
374930004301	Polysaccharide biosynthesis protein; Region: Polysacc_synt; cl10513
374930004302	potential frameshift: common BLAST hit: gi|68249460|ref|YP_248572.1| glutamine synthetase [Haemophilus influenzae 86-028NP]
374930004303	Alpha-2,3-sialyltransferase (CST-I); Region: CST-I; pfam06002
374930004304	Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217
374930004305	TypA (tyrosine phosphorylated protein A)/BipA subfamily.  BipA is a protein belonging to the ribosome-binding family of GTPases and is widely distributed in bacteria and plants.  BipA was originally described as a protein that is induced in Salmonella...; Region: TypA_BipA; cd01891
374930004306	G1 box; other site
374930004307	putative GEF interaction site [polypeptide binding]; other site
374930004308	GTP/Mg2+ binding site [chemical binding]; other site
374930004309	Switch I region; other site
374930004310	G2 box; other site
374930004311	G3 box; other site
374930004312	Switch II region; other site
374930004313	G4 box; other site
374930004314	G5 box; other site
374930004315	BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu.  BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691
374930004316	BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants.  BipA is a...; Region: BipA_TypA_C; cd03710
374930004317	pyridoxamine 5'-phosphate oxidase; Provisional; Region: PRK05679
374930004318	Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381
374930004319	Pyridoxine 5'-phosphate oxidase C-terminal dimerisation region; Region: PNPOx_C; pfam10590
374930004320	Uncharacterized ACR, YhhQ family COG1738; Region: DUF165; cl00756
374930004321	Ribonuclease R winged-helix domain; Region: HTH_12; pfam08461
374930004322	VacB and RNase II family 3'-5' exoribonucleases; Region: 3_prime_RNase; TIGR00358
374930004323	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain...; Region: S1_like; cl09927
374930004324	RNB domain; Region: RNB; pfam00773
374930004325	S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase play an...; Region: S1_RNase_R; cd04471
374930004326	RNA binding site [nucleotide binding]; other site
374930004327	23S rRNA (guanosine-2'-O-)-methyltransferase; Provisional; Region: PRK11181
374930004328	RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032
374930004329	SpoU rRNA Methylase family; Region: SpoU_methylase; cl00362
374930004330	ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346
374930004331	Clp amino terminal domain; Region: Clp_N; pfam02861
374930004332	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009
374930004333	Walker A motif; other site
374930004334	ATP binding site [chemical binding]; other site
374930004335	Walker B motif; other site
374930004336	arginine finger; other site
374930004337	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009
374930004338	Walker A motif; other site
374930004339	ATP binding site [chemical binding]; other site
374930004340	Walker B motif; other site
374930004341	arginine finger; other site
374930004342	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431
374930004343	5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; cl00360
374930004344	Cell division protein ZapA; Region: ZapA; cl01146
374930004345	DNA polymerase I; Provisional; Region: PRK05755
374930004346	PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859
374930004347	active site
374930004348	metal binding site 1 [ion binding]; metal-binding site
374930004349	putative 5' ssDNA interaction site; other site
374930004350	metal binding site 3; metal-binding site
374930004351	metal binding site 2 [ion binding]; metal-binding site
374930004352	H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898
374930004353	putative DNA binding site [nucleotide binding]; other site
374930004354	putative metal binding site [ion binding]; other site
374930004355	DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase I and similar bacterial family-A DNA polymerases; Region: DNA_polA_I_Ecoli_like_exo; cd06139
374930004356	active site
374930004357	catalytic site [active]
374930004358	substrate binding site [chemical binding]; other site
374930004359	Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637
374930004360	active site
374930004361	DNA binding site [nucleotide binding]
374930004362	catalytic site [active]
374930004363	L-cysteine desulfidase [Amino acid transport and metabolism]; Region: COG3681
374930004364	Putative heme iron utilization protein [Inorganic ion transport and metabolism]; Region: HugZ; COG0748
374930004365	Protein of unknown function (DUF2470); Region: DUF2470; pfam10615
374930004366	Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381
374930004367	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
374930004368	The substrate-binding component of an ABC-type dipeptide import system contains the type 2 periplasmic binding fold; Region: PBP2_DppA_like; cd08493
374930004369	peptide binding site [polypeptide binding]; other site
374930004370	potential frameshift: common BLAST hit: gi|52426109|ref|YP_089246.1| ProP protein [Mannheimia succiniciproducens MBEL55E]
374930004371	Molybdenum is an essential trace element in the form of molybdenum cofactor (Moco) which is associated with the metabolism of nitrogen, carbon and sulfur by redox active enzymes. In E. coli, the synthesis of Moco involves genes from several loci: moa...; Region: MobB; cd03116
374930004372	Walker A motif; other site
374930004373	similar to hypothetical protein; COG1763 Molybdopterin-guanine dinucleotide biosynthesis protein
374930004374	Positive regulator of sigma(E), RseC/MucC; Region: RseC_MucC; cl01178
374930004375	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011
374930004376	tRNA (uracil-5-)-methyltransferase; Validated; Region: PRK05031
374930004377	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011
374930004378	Protein of unknown function, DUF; Region: DUF413; cl10479
374930004379	DsbA family, DsbA subfamily; DsbA is a monomeric thiol disulfide oxidoreductase protein containing a redox active CXXC motif imbedded in a TRX fold. It is involved in the oxidative protein folding pathway in prokaryotes, and is the strongest thiol...; Region: DsbA_DsbA; cd03019
374930004380	DSBA-like thioredoxin domain; Region: DSBA; pfam01323
374930004381	catalytic residues [active]
374930004382	hinge region; other site
374930004383	alpha helical domain; other site
374930004384	Protein of unknown function (DUF1040); Region: DUF1040; cl01176
374930004385	MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503
374930004386	GTP binding site [chemical binding]; other site
374930004387	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have...; Region: metallo-dependent_hydrolases; cl00281
374930004388	active site
374930004389	potential frameshift: common BLAST hit: gi|68249436|ref|YP_248548.1| predicted hydrolase of alkaline phosphatase superfamily
374930004390	Protein of unknown function (DUF1414); Region: DUF1414; cl01175
374930004391	Nucleoid-associated protein [General function prediction only]; Region: COG3081
374930004392	nucleoid-associated protein NdpA; Validated; Region: PRK00378
374930004393	SmpA / OmlA family; Region: SmpA_OmlA; cl01095
374930004394	DNA-binding transcriptional regulator CpxR; Provisional; Region: PRK10955
374930004395	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156
374930004396	active site
374930004397	phosphorylation site [posttranslational modification]
374930004398	intermolecular recognition site; other site
374930004399	dimerization interface [polypeptide binding]; other site
374930004400	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase...; Region: trans_reg_C; cd00383
374930004401	DNA binding site [nucleotide binding]
374930004402	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075
374930004403	two-component sensor protein; Provisional; Region: cpxA; PRK09470
374930004404	poxB regulator PoxA; Provisional; Region: PRK09350
374930004405	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
374930004406	motif 1; other site
374930004407	dimer interface [polypeptide binding]; other site
374930004408	active site
374930004409	motif 2; other site
374930004410	motif 3; other site
374930004411	fumarate reductase flavoprotein subunit; Validated; Region: PRK09231
374930004412	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644
374930004413	domain; Region: Succ_DH_flav_C; pfam02910
374930004414	fumarate reductase iron-sulfur subunit; Provisional; Region: PRK12385
374930004415	Quinol:fumarate reductase (QFR) Type D subfamily, 15kD hydrophobic subunit C;  QFR couples the reduction of fumarate to succinate to the oxidation of quinol to quinone, the opposite reaction to that catalyzed by the related protein, succinate:quinine...; Region: QFR_TypeD_subunitC; cd00546
374930004416	D-subunit interface [polypeptide binding]; other site
374930004417	Iron-sulfur protein interface; other site
374930004418	proximal quinone binding site [chemical binding]; other site
374930004419	distal quinone binding site [chemical binding]; other site
374930004420	Quinol:fumarate reductase (QFR) Type D subfamily, 13kD hydrophobic subunit D; QFR couples the reduction of fumarate to succinate to the oxidation of quinol to quinone, the opposite reaction to that catalyzed by the related protein, succinate:quinine...; Region: QFR_TypeD_subunitD; cd00547
374930004421	Iron-sulfur protein interface; other site
374930004422	proximal quinone binding site [chemical binding]; other site
374930004423	C-subunit interface; other site
374930004424	distal quinone binding site; other site
374930004425	Transglycosylase; Region: Transgly; cl07896
374930004426	Trp repressor protein; Region: Trp_repressor; cl01121
374930004427	lytic murein transglycosylase; Provisional; Region: PRK11619
374930004428	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic 'goose-type' lysozymes (GEWL).  LTs catalyze...; Region: LT_GEWL; cd00254
374930004429	N-acetyl-D-glucosamine binding site [chemical binding]; other site
374930004430	catalytic residue [active]
374930004431	YCII-related domain; Region: YCII; cl00999
374930004432	Brown fat-inducible thioesterase (BFIT).  Brain acyl-CoA hydrolase (BACH).  These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain...; Region: BFIT_BACH; cd03442
374930004433	Intracellular septation protein A; Region: IspA; cl01098
374930004434	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
374930004435	TM-ABC transporter signature motif; other site
374930004436	This family represents the domain I of the carbohydrate uptake proteins that transport only monosaccharides (Monos).  The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and...; Region: ABC_Carb_Monos_I; cd03216
374930004437	galactose/methyl galaxtoside transporter ATP-binding protein; Provisional; Region: PRK10982
374930004438	Walker A/P-loop; other site
374930004439	ATP binding site [chemical binding]; other site
374930004440	Q-loop/lid; other site
374930004441	ABC transporter signature motif; other site
374930004442	Walker B; other site
374930004443	D-loop; other site
374930004444	H-loop/switch region; other site
374930004445	This family represents domain II of the carbohydrate uptake proteins that transport only monosaccharides (Monos).  The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and hexoses (; Region: ABC_Carb_Monos_II; cd03215
374930004446	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879
374930004447	Periplasmic glucose/galactose-binding protein (GGBP) involved in chemotaxis towards, and active transport of, glucose and galactose in various bacterial species; Region: PBP1_GGBP; cd01539
374930004448	ligand binding site [chemical binding]; other site
374930004449	calcium binding site [ion binding]; other site
374930004450	DNA-binding transcriptional regulator GalS; Provisional; Region: PRK10401
374930004451	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
374930004452	DNA binding site [nucleotide binding]
374930004453	domain linker motif; other site
374930004454	Ligand binding domain of DNA transcription iso-repressor GalS, which is one of two regulatory proteins involved in galactose transport and metabolism; Region: PBP1_GalS_like; cd06270
374930004455	ligand binding site [chemical binding]; other site
374930004456	dimerization interface (closed form) [polypeptide binding]; other site
374930004457	galactose-1-phosphate uridylyltransferase; Provisional; Region: PRK11720
374930004458	Galactose-1-phosphate uridyl transferase (GalT): This enzyme plays a key role in galactose metabolism by catalysing the transfer of a uridine 5'-phosphoryl group from UDP-galactose 1-phosphate. The structure of E.coli GalT reveals that the enzyme...; Region: GalT; cd00608
374930004459	dimer interface [polypeptide binding]; other site
374930004460	active site
374930004461	galactokinase; Provisional; Region: PRK05101
374930004462	Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509
374930004463	GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544
374930004464	Galactose mutarotase and related enzymes [Carbohydrate transport and metabolism]; Region: GalM; COG2017
374930004465	galactose mutarotase_like; Region: galactose_mutarotase_like; cd09019
374930004466	active site
374930004467	catalytic residues [active]
374930004468	Uncharacterised protein family (UPF0149); Region: UPF0149; cl01173
374930004469	Aminopeptidase P, N-terminal domain; Region: AMP_N; pfam05195
374930004470	proline aminopeptidase P II; Provisional; Region: PRK10879
374930004471	Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action...; Region: Prolidase; cd01087
374930004472	active site
374930004473	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
374930004474	Ligand Binding Site [chemical binding]; other site
374930004475	alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252
374930004476	Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent formation...; Region: AlaRS_core; cd00673
374930004477	motif 1; other site
374930004478	active site
374930004479	motif 2; other site
374930004480	motif 3; other site
374930004481	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; cl08469
374930004482	DHHA1 domain; Region: DHHA1; pfam02272
374930004483	Global regulator protein family; Region: CsrA; cl00670
374930004484	Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541
374930004485	active site
374930004486	tetramer interface [polypeptide binding]; other site
374930004487	argininosuccinate lyase; Provisional; Region: PRK04833
374930004488	Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359
374930004489	active sites [active]
374930004490	tetramer interface [polypeptide binding]; other site
374930004491	Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114
374930004492	Heat shock protein 33 (Hsp33):  Cytosolic protein that acts as a molecular chaperone under oxidative conditions.  In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498
374930004493	dimerization interface [polypeptide binding]; other site
374930004494	domain crossover interface; other site
374930004495	redox-dependent activation switch; other site
374930004496	Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_ATP; cd00484
374930004497	active site
374930004498	substrate-binding site [chemical binding]; other site
374930004499	metal-binding site [ion binding]
374930004500	ATP binding site [chemical binding]; other site
374930004501	Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation.  Thus ribosomes are 'recycled' and ready for another round of...; Region: RRF; cd00520
374930004502	hinge region; other site
374930004503	1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447
374930004504	1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670
374930004505	1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436
374930004506	Predicted permeases [General function prediction only]; Region: COG0730; cl00498
374930004507	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
374930004508	anaerobic sulfatase-maturating enzyme; Region: sulfatase_rSAM; TIGR03942
374930004509	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster...; Region: Radical_SAM; cd01335
374930004510	FeS/SAM binding site; other site
374930004511	radical SAM additional 4Fe4S-binding domain; Region: rSAM_more_4Fe4S; TIGR04085
374930004512	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088
374930004513	Ribosomal protein L17; Region: Ribosomal_L17; cl00356
374930004514	DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182
374930004515	N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928
374930004516	alphaNTD homodimer interface [polypeptide binding]; other site
374930004517	alphaNTD - beta interaction site [polypeptide binding]; other site
374930004518	alphaNTD - beta' interaction site [polypeptide binding]; other site
374930004519	Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; cl11613
374930004520	30S ribosomal protein S4; Validated; Region: rpsD; PRK05327
374930004521	Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163
374930004522	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
374930004523	RNA binding surface [nucleotide binding]; other site
374930004524	Ribosomal protein S11; Region: Ribosomal_S11; cl00332
374930004525	Ribosomal protein S13/S18; Region: Ribosomal_S13; cl00331
374930004526	Ribosomal protein S13 [Translation, ribosomal structure and biogenesis]; Region: RpsM; COG0099
374930004527	Ribosomal protein L36; Region: Ribosomal_L36; cl00380
374930004528	preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204
374930004529	SecY translocase; Region: SecY; pfam00344
374930004530	Ribosomal protein L18e/L15; Region: Ribosomal_L18e; cl12022
374930004531	Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins...; Region: Ribosomal_L30; cd01658
374930004532	23S rRNA binding site [nucleotide binding]; other site
374930004533	30S ribosomal protein S5; Validated; Region: rpsE; PRK00550
374930004534	Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333
374930004535	Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719
374930004536	Ribosomal L18/L5e:  L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432
374930004537	5S rRNA interface [nucleotide binding]; other site
374930004538	L27 interface [polypeptide binding]; other site
374930004539	23S rRNA interface [nucleotide binding]; other site
374930004540	L5 interface [polypeptide binding]; other site
374930004541	50S ribosomal protein L6; Validated; Region: rplF; PRK05498
374930004542	Ribosomal protein L6; Region: Ribosomal_L6; pfam00347
374930004543	Ribosomal protein L6; Region: Ribosomal_L6; pfam00347
374930004544	Ribosomal protein S8; Region: Ribosomal_S8; cl00330
374930004545	Ribosomal protein S14p/S29e; Region: Ribosomal_S14; cl00355
374930004546	50S ribosomal protein L5; Validated; Region: rplE; PRK00010
374930004547	Ribosomal protein L5; Region: Ribosomal_L5; pfam00281
374930004548	ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673
374930004549	KOW motif; Region: KOW; cl00354
374930004550	Ribosomal protein L14p/L23e; Region: Ribosomal_L14; cl00328
374930004551	Ribosomal protein S17; Region: Ribosomal_S17; cl00351
374930004552	Ribosomal L29 protein/HIP.  L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals.  L29 is located on the surface of the large ribosomal subunit, where...; Region: Ribosomal_L29_HIP; cl09943
374930004553	Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433
374930004554	23S rRNA interface [nucleotide binding]; other site
374930004555	5S rRNA interface [nucleotide binding]; other site
374930004556	putative antibiotic binding site [chemical binding]; other site
374930004557	L25 interface [polypeptide binding]; other site
374930004558	L27 interface [polypeptide binding]; other site
374930004559	30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310
374930004560	K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3  is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel.  The...; Region: 30S_S3_KH; cd02412
374930004561	G-X-X-G motif; other site
374930004562	Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189
374930004563	Ribosomal protein L22/L17e.  L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit.  It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336
374930004564	protein-rRNA interface [nucleotide binding]; other site
374930004565	putative translocon binding site; other site
374930004566	Ribosomal protein S19; Region: Ribosomal_S19; cl00350
374930004567	50S ribosomal protein L2; Validated; Region: rplB; PRK09374
374930004568	Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181
374930004569	Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947
374930004570	Ribosomal protein L23; Region: Ribosomal_L23; cl00326
374930004571	Ribosomal protein L4/L1 family; Region: Ribosomal_L4; cl00325
374930004572	potential frameshift: common BLAST hit: gi|68249373|ref|YP_248485.1| 50S ribosomal protein L3 [Haemophilus influenzae 86-028NP]
374930004573	Ribosomal protein S10p/S20e; Region: Ribosomal_S10; cl00314
374930004574	autoinducer-2 (AI-2) kinase; Provisional; Region: PRK10939
374930004575	FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121
374930004576	FGGY family of carbohydrate kinases, C-terminal domain; Region: FGGY_C; pfam02782
374930004577	transcriptional regulator LsrR; Provisional; Region: PRK15418
374930004578	Putative sugar-binding domain; Region: Sugar-bind; pfam04198
374930004579	potential frameshift: common BLAST hit: gi|113460200|ref|YP_718257.1| ABC transporter, ATP-binding, sugar transport [Haemophilus somnus]
374930004580	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
374930004581	TM-ABC transporter signature motif; other site
374930004582	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
374930004583	TM-ABC transporter signature motif; other site
374930004584	autoinducer 2-binding protein lsrB; Provisional; Region: PRK15408
374930004585	Periplasmic binding domain of autoinducer-2 (AI-2) receptor LsrB from Salmonella typhimurium and its close homologs; Region: PBP1_LsrB_Quorum_Sensing; cd06302
374930004586	ligand binding site [chemical binding]; other site
374930004587	DhnA-type fructose-1,6-bisphosphate aldolase and related enzymes [Carbohydrate transport and metabolism]; Region: FbaB; COG1830
374930004588	Class I fructose-1,6-bisphosphate (FBP) aldolases of the archaeal type (DhnA homologs); Region: DhnA; cd00958
374930004589	putative active site; other site
374930004590	catalytic residue [active]
374930004591	Antibiotic biosynthesis monooxygenase; Region: ABM; cl10022
374930004592	Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036
374930004593	Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative...; Region: RPE; cd00429
374930004594	substrate binding site [chemical binding]; other site
374930004595	hexamer interface [polypeptide binding]; other site
374930004596	metal binding site [ion binding]; metal-binding site
374930004597	cell division ABC transporter subunit FtsX; Provisional; Region: ftsX; PRK11026
374930004598	Type II (General) Secretory Pathway (IISP) Family protein; Region: 3a0501s02; TIGR00960
374930004599	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099
374930004600	Walker A/P-loop; other site
374930004601	ATP binding site [chemical binding]; other site
374930004602	Q-loop/lid; other site
374930004603	ABC transporter signature motif; other site
374930004604	Walker B; other site
374930004605	D-loop; other site
374930004606	H-loop/switch region; other site
374930004607	signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416
374930004608	SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881
374930004609	The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115
374930004610	P loop; other site
374930004611	GTP binding site [chemical binding]; other site
374930004612	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440
374930004613	S-adenosylmethionine binding site [chemical binding]; other site
374930004614	SpoU rRNA Methylase family; Region: SpoU_methylase; cl00362
374930004615	Glycosyltransferase family 25 [lipooligosaccharide (LOS) biosynthesis protein] is a family of glycosyltransferases involved in LOS biosynthesis. The members include the beta(1,4) galactosyltransferases: Lgt2 of Moraxella catarrhalis, LgtB and LgtE of...; Region: Glyco_transf_25; cd06532
374930004616	3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; cl00336
374930004617	potential frameshift: common BLAST hit: gi|68249359|ref|YP_248471.1| nicotinamide-nucleotide adenylyltransferase [Haemophilus influenzae]
374930004618	Predicted phosphoesterases, related to the Icc protein [General function prediction only]; Region: COG2129
374930004619	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
374930004620	active site
374930004621	metal binding site [ion binding]; metal-binding site
374930004622	murein transglycosylase C; Provisional; Region: mltC; PRK11671
374930004623	Domain of unknown function (DUF3393); Region: DUF3393; pfam11873
374930004624	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic 'goose-type' lysozymes (GEWL).  LTs catalyze...; Region: LT_GEWL; cd00254
374930004625	N-acetyl-D-glucosamine binding site [chemical binding]; other site
374930004626	catalytic residue [active]
374930004627	Bacterial Fe(2+) trafficking; Region: Iron_traffic; cl01104
374930004628	adenine DNA glycosylase; Provisional; Region: PRK10880
374930004629	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
374930004630	minor groove reading motif; other site
374930004631	helix-hairpin-helix signature motif; other site
374930004632	substrate binding pocket [chemical binding]; other site
374930004633	active site
374930004634	FES domain; Region: FES; smart00525
374930004635	DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread  A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431
374930004636	DNA binding and oxoG recognition site [nucleotide binding]
374930004637	Ribosomal protein L31; Region: Ribosomal_L31; cl00377
374930004638	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
374930004639	catalytic core [active]
374930004640	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
374930004641	potential frameshift: common BLAST hit: gi|68249352|ref|YP_248464.1| predicted membrane-bound metallopeptidase [Haemophilus influenzae]
374930004642	Divergent polysaccharide deacetylase; Region: Polysacc_deac_2; cl04721
374930004643	Glycosyltransferase family 25 [lipooligosaccharide (LOS) biosynthesis protein] is a family of glycosyltransferases involved in LOS biosynthesis. The members include the beta(1,4) galactosyltransferases: Lgt2 of Moraxella catarrhalis, LgtB and LgtE of...; Region: Glyco_transf_25; cd06532
374930004644	phosphoribosylformylglycinamidine synthase; Provisional; Region: PRK05297
374930004645	PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP...; Region: PurL_repeat1; cd02203
374930004646	dimerization interface [polypeptide binding]; other site
374930004647	ATP binding site [chemical binding]; other site
374930004648	PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP...; Region: PurL_repeat2; cd02204
374930004649	dimerization interface [polypeptide binding]; other site
374930004650	ATP binding site [chemical binding]; other site
374930004651	Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740
374930004652	putative active site [active]
374930004653	catalytic triad [active]
374930004654	Protein of unknown function (DUF1440); Region: DUF1440; cl01380
374930004655	Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014
374930004656	dimer interface [polypeptide binding]; other site
374930004657	catalytic triad [active]
374930004658	peroxidatic and resolving cysteines [active]
374930004659	diaminopimelate epimerase; Provisional; Region: dapF; PRK00450
374930004660	Diaminopimelate epimerase; Region: DAP_epimerase; cl14668
374930004661	Diaminopimelate epimerase; Region: DAP_epimerase; cl14668
374930004662	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088
374930004663	LexA repressor; Validated; Region: PRK00215
374930004664	Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (...; Region: S24_LexA-like; cd06529
374930004665	Catalytic site [active]
374930004666	Glycerol-3-phosphate O-acyltransferase [Lipid metabolism]; Region: PlsB; COG2937
374930004667	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: GPAT-like; Region: LPLAT_DHAPAT-like; cd07993
374930004668	putative acyl-acceptor binding pocket; other site
374930004669	NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252
374930004670	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644
374930004671	Anaerobic c4-dicarboxylate membrane transporter; Region: DcuA_DcuB; cl01040
374930004672	Asparaginase (amidohydrolase): Asparaginases are tetrameric enzymes that catalyze the hydrolysis of asparagine to aspartic acid and ammonia. In bacteria, there are two classes of amidohydrolases, one  highly specific for asparagine and localised to the...; Region: Asparaginase; cd00411
374930004673	active site/substrate binding site [active]
374930004674	tetramer interface [polypeptide binding]; other site
374930004675	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
374930004676	active site residue [active]
374930004677	Preprotein translocase subunit SecB. SecB is a cytoplasmic component of the multisubunit membrane-bound enzyme termed Sec protein translocase, which is the main constituent of the General Secretory (type II) Pathway involved in translocation of nascent...; Region: Translocase_SecB; cd00557
374930004678	SecA binding site; other site
374930004679	Preprotein binding site; other site
374930004680	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
374930004681	similar to hypothetical protein; COG0702 Predicted nucleoside-diphosphate-sugar epimerases
374930004682	phosphoglucomutase-2-like protein; Provisional; Region: PTZ00150
374930004683	This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and deoxyribose-1-...; Region: PGM2; cd05799
374930004684	active site
374930004685	substrate binding site [chemical binding]; other site
374930004686	metal binding site [ion binding]; metal-binding site
374930004687	potential frameshift: common BLAST hit: gi|16272681|ref|NP_438899.1| DNA polymerase III subunit alpha [Haemophilus influenzae Rd KW20]
374930004688	threonine dehydratase; Reviewed; Region: PRK09224
374930004689	Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562
374930004690	tetramer interface [polypeptide binding]; other site
374930004691	pyridoxal 5'-phosphate binding site [chemical binding]; other site
374930004692	catalytic residue [active]
374930004693	First of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_1; cd04906
374930004694	putative Ile/Val binding site [chemical binding]; other site
374930004695	Second of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_2; cd04907
374930004696	putative Ile/Val binding site [chemical binding]; other site
374930004697	Dehydratase family; Region: ILVD_EDD; cl00340
374930004698	dihydroxy-acid dehydratase; Region: ilvD; TIGR00110
374930004699	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
374930004700	PYR/PP interface [polypeptide binding]; other site
374930004701	dimer interface [polypeptide binding]; other site
374930004702	TPP binding site [chemical binding]; other site
374930004703	acetolactate synthase 2 catalytic subunit; Reviewed; Region: PRK08978
374930004704	Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin...; Region: TPP_enzymes; cl01629
374930004705	ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141
374930004706	Sodium:neurotransmitter symporter family; Region: SNF; cl11976
374930004707	Escherichia coli YbbF/LpxH and related proteins, metallophosphatase domain; Region: MPP_YbbF-LpxH; cd07398
374930004708	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
374930004709	putative active site [active]
374930004710	putative metal binding site [ion binding]; other site
374930004711	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
374930004712	putative acyl-acceptor binding pocket; other site
374930004713	FtsI repressor; Provisional; Region: PRK10883
374930004714	Multicopper oxidase; Region: Cu-oxidase; cl14658
374930004715	potential frameshift: common BLAST hit: gi|68249331|ref|YP_248443.1| organic solvent tolerance protein precursor [Haemophilus influenzae]
374930004716	prolyl-tRNA synthetase; Provisional; Region: PRK09194
374930004717	Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent formation...; Region: ProRS_core_prok; cd00779
374930004718	dimer interface [polypeptide binding]; other site
374930004719	motif 1; other site
374930004720	active site
374930004721	motif 2; other site
374930004722	INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and single-...; Region: ProRS-INS; cd04334
374930004723	putative deacylase active site [active]
374930004724	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
374930004725	active site
374930004726	motif 3; other site
374930004727	ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-...; Region: ProRS_anticodon_short; cd00861
374930004728	anticodon binding site; other site
374930004729	ATP-dependent DNA helicase RecQ; Provisional; Region: PRK11057
374930004730	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
374930004731	ATP binding site [chemical binding]; other site
374930004732	putative Mg++ binding site [ion binding]; other site
374930004733	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
374930004734	nucleotide binding region [chemical binding]; other site
374930004735	ATP-binding site [chemical binding]; other site
374930004736	RQC domain; Region: RQC; pfam09382
374930004737	HRDC domain; Region: HRDC; cl02578
374930004738	Frataxin is a nuclear-encoded mitochondrial protein implicated in Friedreich's ataxia (FRDA), an human autosomal recessive neurodegenerative disease; Frataxin is found in eukaryotes and in purple bacteria; lack of frataxin causes iron to accumulate in...; Region: Frataxin; cd00503
374930004739	putative iron binding site [ion binding]; other site
374930004740	Predicted small periplasmic lipoprotein [Cell motility and secretion]; Region: COG5567
374930004741	diaminopimelate decarboxylase; Region: lysA; TIGR01048
374930004742	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828
374930004743	active site
374930004744	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
374930004745	substrate binding site [chemical binding]; other site
374930004746	catalytic residues [active]
374930004747	dimer interface [polypeptide binding]; other site
374930004748	transcriptional regulator NarP; Provisional; Region: PRK10403
374930004749	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156
374930004750	active site
374930004751	phosphorylation site [posttranslational modification]
374930004752	intermolecular recognition site; other site
374930004753	dimerization interface [polypeptide binding]; other site
374930004754	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors...; Region: LuxR_C_like; cd06170
374930004755	DNA binding residues [nucleotide binding]
374930004756	dimerization interface [polypeptide binding]; other site
374930004757	Protein of unknown function (DUF2489); Region: DUF2489; pfam10675
374930004758	Protein of unknown function, DUF414; Region: DUF414; cl01172
374930004759	Cation transport protein; Region: TrkH; cl10514
374930004760	potassium uptake protein, TrkH family; Region: 2a38; TIGR00933
374930004761	uncharacterized protein, YigZ family; Region: IMPACT_YIGZ; TIGR00257
374930004762	Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205
374930004763	Domain of unknown function (DUF1949); Region: DUF1949; pfam09186
374930004764	SirA (also known as UvrY,  and YhhP) belongs to a family of two-component response regulators that controls secondary metabolism and virulence. The other member of this two-component system is a sensor kinase called BarA which phosphorylates SirA.  A...; Region: SirA; cd03423
374930004765	CPxP  motif; other site
374930004766	Peptidase family M48; Region: Peptidase_M48; cl12018
374930004767	YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448
374930004768	homotrimer interaction site [polypeptide binding]; other site
374930004769	putative active site [active]
374930004770	VacJ like lipoprotein; Region: VacJ; cl01073
374930004771	transcription antitermination protein NusG; Validated; Region: nusG; PRK05609
374930004772	Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891
374930004773	putative homodimer interface [polypeptide binding]; other site
374930004774	KOW motif; Region: KOW; cl00354
374930004775	SecE/Sec61-gamma subunits of protein translocation complex; Region: SecE; cl00481
374930004776	ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342
374930004777	ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689
374930004778	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099
374930004779	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009
374930004780	Walker A motif; other site
374930004781	ATP binding site [chemical binding]; other site
374930004782	Walker B motif; other site
374930004783	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431
374930004784	Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017
374930004785	oligomer interface [polypeptide binding]; other site
374930004786	active site residues [active]
374930004787	trigger factor; Provisional; Region: tig; PRK01490
374930004788	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; cl11587
374930004789	Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698
374930004790	potential frameshift: common BLAST hit: gi|30995391|ref|NP_438795.2| hemoglobin-binding protein [Haemophilus influenzae Rd KW20]
374930004791	Plasmid stabilisation system protein; Region: Plasmid_stabil; cl11422
374930004792	RelB antitoxin; Region: RelB; cl01171
374930004793	Protein of unknown function (DUF3298); Region: DUF3298; pfam11738
374930004794	selenocysteine-specific elongation factor SelB; Region: selB; TIGR00475
374930004795	SelB subfamily.  SelB is an elongation factor needed for the co-translational incorporation of selenocysteine.  Selenocysteine is coded by a UGA stop codon in combination with a specific downstream mRNA hairpin.  In bacteria, the C-terminal part of...; Region: SelB; cd04171
374930004796	G1 box; other site
374930004797	putative GEF interaction site [polypeptide binding]; other site
374930004798	GTP/Mg2+ binding site [chemical binding]; other site
374930004799	Switch I region; other site
374930004800	G2 box; other site
374930004801	G3 box; other site
374930004802	Switch II region; other site
374930004803	G4 box; other site
374930004804	G5 box; other site
374930004805	selB_II: this subfamily represents the domain of elongation factor SelB, homologous to domain II of EF-Tu. SelB may function by replacing EF-Tu. In prokaryotes, the incorporation of selenocysteine as the 21st amino acid, encoded by TGA, requires...; Region: selB_II; cd03696
374930004806	This family represents the domain of elongation factor SelB, homologous to domain III of EF-Tu. SelB may function by replacing EF-Tu. In prokaryotes, the incorporation of selenocysteine as the 21st amino acid, encoded by TGA, requires several elements:...; Region: selB_III; cd04094
374930004807	Elongation factor SelB, winged helix; Region: SelB-wing_2; pfam09106
374930004808	Egl-10, and Pleckstrin, where this domain was first discovered. The function of this domain is still not clear, but it is believed to be important for the membrane association of the signaling proteins in which it is present. New studies show that the...; Region: DEP; cl02442
374930004809	Elongation factor SelB, winged helix; Region: SelB-wing_3; pfam09107
374930004810	selenocysteine synthase; Provisional; Region: PRK04311
374930004811	Selenocysteine synthase N terminal; Region: Se-cys_synth_N; pfam12390
374930004812	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
374930004813	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
374930004814	catalytic residue [active]
374930004815	Archaeal ATPase; Region: Arch_ATPase; pfam01637
374930004816	Clostripain family; Region: Peptidase_C11; cl04055
374930004817	DNA mismatch repair protein MutS; Provisional; Region: PRK05399
374930004818	MutS domain I; Region: MutS_I; pfam01624
374930004819	MutS domain II; Region: MutS_II; pfam05188
374930004820	MutS family domain IV; Region: MutS_IV; pfam05190
374930004821	MutS1 homolog in eukaryotes.  The MutS protein initiates DNA mismatch repair by recognizing mispaired and unpaired bases embedded in duplex DNA and activating endo- and exonucleases to remove the mismatch.  Members of the MutS family possess C-terminal...; Region: ABC_MutS1; cd03284
374930004822	Walker A/P-loop; other site
374930004823	ATP binding site [chemical binding]; other site
374930004824	Q-loop/lid; other site
374930004825	ABC transporter signature motif; other site
374930004826	Walker B; other site
374930004827	D-loop; other site
374930004828	H-loop/switch region; other site
374930004829	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
374930004830	Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118
374930004831	putative peptidoglycan binding site; other site
374930004832	Peptidase family M23; Region: Peptidase_M23; pfam01551
374930004833	SNARE associated Golgi protein; Region: SNARE_assoc; cl00429
374930004834	Survival protein SurE; Region: SurE; cl00448
374930004835	tRNA pseudouridine synthase D; Reviewed; Region: truD; PRK00984
374930004836	PseudoU_synth_EcTruD: Pseudouridine synthase, TruD family. This group consists of bacterial pseudouridine synthases similar to Escherichia coli TruD. Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to...; Region: PseudoU_synth_EcTruD; cd02575
374930004837	Permutation of conserved domain; other site
374930004838	active site
374930004839	PseudoU_synth:  Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi). Pseudouridine synthases contains the RsuA/RluD, TruA, TruB and TruD families.  This group consists of...; Region: PseudoU_synth; cl00130
374930004840	Protein of unknown function (DUF1260); Region: DUF1260; cl01170
374930004841	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; cl11587
374930004842	Outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG0729
374930004843	Surface antigen; Region: Bac_surface_Ag; cl03097
374930004844	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2911
374930004845	Family of unknown function (DUF490); Region: DUF490; pfam04357
374930004846	Family of unknown function (DUF490); Region: DUF490; pfam04357
374930004847	exopolyphosphatase; Region: exo_poly_only; TIGR03706
374930004848	Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541
374930004849	23S rRNA pseudouridine synthase E; Provisional; Region: PRK11394
374930004850	PseudoU_synth_RluE: Pseudouridine synthase, Escherichia coli RluE. This group is comprised of bacterial proteins similar to E. coli RluE. Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-...; Region: PseudoU_synth_RluE; cd02566
374930004851	probable active site [active]
374930004852	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cl11391
374930004853	Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615
374930004854	ketol-acid reductoisomerase; Validated; Region: PRK05225
374930004855	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
374930004856	Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450
374930004857	Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450
374930004858	DNA-binding transcriptional regulator IlvY; Provisional; Region: PRK11716
374930004859	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088
374930004860	The C-terminal substrate binding of LysR-type transcriptional regulator IlvY, which activates the expression of ilvC gene that encoding acetohydroxy acid isomeroreductase for the biosynthesis of branched amino acids; contains the type 2 periplasmic bindin; Region: PBP2_IlvY; cd08430
374930004861	putative dimerization interface [polypeptide binding]; other site
374930004862	rarD protein; Region: rarD; TIGR00688
374930004863	GlpE sulfurtransferase (ST) and homologs are members of the Rhodanese Homology Domain superfamily. Unlike other rhodanese sulfurtransferases, GlpE is a single domain protein but indications are that it functions as a dimer. The active site contains a...; Region: GlpE_ST; cd01444
374930004864	active site residue [active]
374930004865	Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311
374930004866	substrate binding site [chemical binding]; other site
374930004867	dimer interface [polypeptide binding]; other site
374930004868	catalytic triad [active]
374930004869	Site-specific recombinase XerC [DNA replication, recombination, and repair]; Region: XerC; COG4973
374930004870	N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination of chromosomal replication, and stable plasmid...; Region: INT_XerDC; cd00798
374930004871	Int/Topo IB signature motif; other site
374930004872	active site
374930004873	aminoacyl-histidine dipeptidase; Region: aa-his-dipept; TIGR01893
374930004874	M20 Peptidase D has specificity for beta-alanyl-L-histidine dipeptide; Region: M20_pepD; cd03890
374930004875	metal binding site [ion binding]; metal-binding site
374930004876	dimer interface [polypeptide binding]; other site
374930004877	Phosphoribosyl transferase domain; Region: Pribosyltran; cl00309
374930004878	glycerol kinase; Provisional; Region: glpK; PRK00047
374930004879	FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121
374930004880	FGGY family of carbohydrate kinases, C-terminal domain; Region: FGGY_C; pfam02782
374930004881	potential frameshift: common BLAST hit: gi|16272632|ref|NP_438850.1| glycerol uptake facilitator protein [Haemophilus influenzae Rd]
374930004882	Glycerophosphodiester phosphodiesterase domain of Escherichia coli (GlpQ) and similar proteins; Region: GDPD_EcGlpQ_like; cd08600
374930004883	Glycerophosphoryl diester phosphodiesterase family; Region: GDPD; pfam03009
374930004884	active site
374930004885	catalytic site [active]
374930004886	metal binding site [ion binding]; metal-binding site
374930004887	glycerol-3-phosphate transporter; Region: glpT; TIGR00712
374930004888	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
374930004889	putative substrate translocation pore; other site
374930004890	sn-glycerol-3-phosphate dehydrogenase subunit A; Provisional; Region: glpA; PRK11101
374930004891	anaerobic glycerol-3-phosphate dehydrogenase subunit B; Validated; Region: PRK05329
374930004892	Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; cl10040
374930004893	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved alpha-; Region: HCP_like; cl14655
374930004894	C subunit; Region: glycerol3P_GlpC; TIGR03379
374930004895	Cysteine-rich domain; Region: CCG; pfam02754
374930004896	Cysteine-rich domain; Region: CCG; pfam02754
374930004897	anchored repeat-type ABC transporter, ATP-binding subunit; Region: anch_rpt_ABC; TIGR03771
374930004898	ABC transporters, involved in the uptake of siderophores, heme, and vitamin B12, are widely conserved in bacteria and archaea.  Only very few species lack representatives of the siderophore family transporters. The E. coli BtuCD protein is an ABC...; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214
374930004899	Walker A/P-loop; other site
374930004900	ATP binding site [chemical binding]; other site
374930004901	Q-loop/lid; other site
374930004902	ABC transporter signature motif; other site
374930004903	Walker B; other site
374930004904	D-loop; other site
374930004905	H-loop/switch region; other site
374930004906	Fe3+-siderophore binding domain FhuD.  These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor...; Region: FhuD; cd01146
374930004907	Periplasmic binding protein; Region: Peripla_BP_2; pfam01497
374930004908	siderophore binding site; other site
374930004909	iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577
374930004910	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist...; Region: TM_ABC_iron-siderophores_like; cd06550
374930004911	ABC-ATPase subunit  interface; other site
374930004912	dimer interface [polypeptide binding]; other site
374930004913	putative PBP binding regions; other site
374930004914	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist...; Region: TM_ABC_iron-siderophores_like; cd06550
374930004915	ABC-ATPase subunit  interface; other site
374930004916	dimer interface [polypeptide binding]; other site
374930004917	putative PBP binding regions; other site
374930004918	TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783
374930004919	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
374930004920	N-terminal plug; other site
374930004921	ligand-binding site [chemical binding]; other site
374930004922	putative transposase OrfB; Reviewed; Region: PHA02517
374930004923	Phosphoribosyl transferase domain; Region: Pribosyltran; cl00309
374930004924	similar to hypothetical protein; COG0503 Adenine/guanine phosphoribosyltransferases and related PRPP-binding proteins
374930004925	Septum formation initiator; Region: DivIC; cl11433
374930004926	CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516
374930004927	substrate binding site [chemical binding]; other site
374930004928	dimer interface [polypeptide binding]; other site
374930004929	MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid...; Region: MECDP_synthase; cd00554
374930004930	homotrimer interaction site [polypeptide binding]; other site
374930004931	zinc binding site [ion binding]; other site
374930004932	CDP-binding sites; other site
374930004933	D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but...; Region: Dtyr_deacylase; cd00563
374930004934	putative active site [active]
374930004935	dimerization interface [polypeptide binding]; other site
374930004936	putative tRNAtyr binding site [nucleotide binding]; other site
374930004937	NADPH-dependent FMN reductase; Region: FMN_red; cl00438
374930004938	Protein of unknown function (DUF904); Region: DUF904; cl11531
374930004939	potential frameshift: common BLAST hit: gi|68249246|ref|YP_248358.1| fructose 1,6-bisphosphatase II [Haemophilus influenzae 86-028NP]
374930004940	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl09100
374930004941	HipA N-terminal domain; Region: couple_hipA; TIGR03071
374930004942	HipA-like N-terminal domain; Region: HipA_N; pfam07805
374930004943	HipA-like C-terminal domain; Region: HipA_C; pfam07804
374930004944	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
374930004945	ABC transporter transmembrane region; Region: ABC_membrane; cl00549
374930004946	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099
374930004947	Walker A/P-loop; other site
374930004948	ATP binding site [chemical binding]; other site
374930004949	Q-loop/lid; other site
374930004950	ABC transporter signature motif; other site
374930004951	Walker B; other site
374930004952	D-loop; other site
374930004953	H-loop/switch region; other site
374930004954	ABC-type transport system involved in cytochrome bd biosynthesis, ATPase and permease components [Energy production and conversion / Posttranslational modification, protein turnover, chaperones]; Region: CydD; COG4988
374930004955	ABC transporter transmembrane region; Region: ABC_membrane; cl00549
374930004956	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099
374930004957	Walker A/P-loop; other site
374930004958	ATP binding site [chemical binding]; other site
374930004959	Q-loop/lid; other site
374930004960	ABC transporter signature motif; other site
374930004961	Walker B; other site
374930004962	D-loop; other site
374930004963	H-loop/switch region; other site
374930004964	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16...; Region: OM_channels; cl00284
374930004965	catecholate siderophore receptor Fiu; Provisional; Region: PRK09840
374930004966	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
374930004967	Phage derived protein Gp49-like (DUF891); Region: Gp49; cl01470
374930004968	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl09100
374930004969	putative ABC transporter ATP-binding protein; Provisional; Region: PRK10636
374930004970	ABCF_EF-3  Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth.  EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by...; Region: ABCF_EF-3; cd03221
374930004971	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099
374930004972	ABCF_EF-3  Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth.  EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by...; Region: ABCF_EF-3; cd03221
374930004973	ABC transporter; Region: ABC_tran_2; pfam12848
374930004974	ABCF_EF-3  Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth.  EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by...; Region: ABCF_EF-3; cd03221
374930004975	Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; cl11977
374930004976	Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; cl11977
374930004977	Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; cl11977
374930004978	yrdC domain; Region: Sua5_yciO_yrdC; cl00305
374930004979	shikimate 5-dehydrogenase; Region: aroE; TIGR00507
374930004980	Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501
374930004981	NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065
374930004982	shikimate binding site; other site
374930004983	NAD(P) binding site [chemical binding]; other site
374930004984	Protein of unknown function (DUF3800); Region: DUF3800; pfam12686
374930004985	Methyladenine glycosylase; Region: Adenine_glyco; cl01059
374930004986	UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511
374930004987	putative metal binding site [ion binding]; other site
374930004988	3-deoxy-D-manno-octulosonic-acid transferase; Reviewed; Region: PRK05749
374930004989	3-Deoxy-D-manno-octulosonic-acid transferase (kdotransferase); Region: Glycos_transf_N; pfam04413
374930004990	Glycosyl transferases group 1; Region: Glycos_transf_1; cl12012
374930004991	Nicotinic acid mononucleotide adenylyltransferase [Coenzyme metabolism]; Region: NadD; COG1057
374930004992	Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163
374930004993	active site
374930004994	(T/H)XGH motif; other site
374930004995	Protein of unknown function (DUF1375); Region: DUF1375; cl11456
374930004996	ATP-dependent DNA helicase Rep; Region: rep; TIGR01074
374930004997	UvrD/REP helicase; Region: UvrD-helicase; cl14126
374930004998	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088
374930004999	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
374930005000	dimerization interface [polypeptide binding]; other site
374930005001	NADPH-dependent FMN reductase; Region: FMN_red; cl00438
374930005002	Uncharacterized membrane protein [Function unknown]; Region: SapB; COG1285
374930005003	MgtC family; Region: MgtC; cl12207
374930005004	aspartate-semialdehyde dehydrogenase; Reviewed; Region: PRK06598
374930005005	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
374930005006	Semialdehyde dehydrogenase, dimerisation domain; Region: Semialdhyde_dhC; pfam02774
374930005007	Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267
374930005008	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
374930005009	trimethylamine-N-oxide reductase c-type cytochrome TorC; Region: torC; TIGR02162
374930005010	cytochrome c-type protein NapC; Provisional; Region: PRK10617; cl09485
374930005011	potential frameshift: common BLAST hit: gi|16272586|ref|NP_438803.1| biotin sulfoxide reductase [Haemophilus influenzae Rd KW20]
374930005012	bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK09451
374930005013	N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540
374930005014	Substrate binding site [chemical binding]; other site
374930005015	Mg++ binding site [ion binding]; other site
374930005016	N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353
374930005017	active site
374930005018	substrate binding site [chemical binding]; other site
374930005019	CoA binding site [chemical binding]; other site
374930005020	Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387
374930005021	core dimer interface [polypeptide binding]; other site
374930005022	peripheral dimer interface [polypeptide binding]; other site
374930005023	L10 interface [polypeptide binding]; other site
374930005024	L11 interface [polypeptide binding]; other site
374930005025	putative EF-Tu interaction site [polypeptide binding]; other site
374930005026	putative EF-G interaction site [polypeptide binding]; other site
374930005027	Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11...; Region: Ribosomal_L10; cd05797
374930005028	23S rRNA interface [nucleotide binding]; other site
374930005029	Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site
374930005030	adenylosuccinate lyase; Provisional; Region: PRK09285
374930005031	PurB_like adenylosuccinases (adenylsuccinate lyase, ASL); Region: PurB; cd01598
374930005032	tetramer interface [polypeptide binding]; other site
374930005033	active site
374930005034	Protein of unknown function (DUF489); Region: DUF489; cl01097
374930005035	tryptophanyl-tRNA synthetase; Region: trpS; TIGR00233
374930005036	catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806
374930005037	active site
374930005038	HIGH motif; other site
374930005039	dimer interface [polypeptide binding]; other site
374930005040	KMSKS motif; other site
374930005041	Protein of unknown function (DUF406); Region: DUF406; cl11449
374930005042	tRNA-dihydrouridine synthase A; Provisional; Region: PRK11815
374930005043	Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and...; Region: DUS_like_FMN; cd02801
374930005044	FMN binding site [chemical binding]; other site
374930005045	active site
374930005046	catalytic residues [active]
374930005047	substrate binding site [chemical binding]; other site
374930005048	elongation factor Tu; Reviewed; Region: PRK00049
374930005049	EF-Tu subfamily.  This subfamily includes orthologs of translation elongation factor EF-Tu in bacteria, mitochondria, and chloroplasts.  It is one of several GTP-binding translation factors found in the larger family of GTP-binding elongation factors; Region: EF_Tu; cd01884
374930005050	G1 box; other site
374930005051	GEF interaction site [polypeptide binding]; other site
374930005052	GTP/Mg2+ binding site [chemical binding]; other site
374930005053	Switch I region; other site
374930005054	G2 box; other site
374930005055	G3 box; other site
374930005056	Switch II region; other site
374930005057	G4 box; other site
374930005058	G5 box; other site
374930005059	EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697
374930005060	Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts)...; Region: EFTU_III; cd03707
374930005061	Antibiotic Binding Site [chemical binding]; other site
374930005062	potential frameshift: common BLAST hit: gi|68249180|ref|YP_248292.1| pantothenate kinase [Haemophilus influenzae 86-028NP]
374930005063	Outer membrane lipoprotein carrier protein LolA; Region: LolA; cl01065
374930005064	Negative regulator of sigma E activity [Signal transduction mechanisms]; Region: RseA; COG3073
374930005065	Anti sigma-E protein RseA, N-terminal domain; Region: RseA_N; pfam03872
374930005066	Anti sigma-E protein RseA, C-terminal domain; Region: RseA_C; pfam03873
374930005067	RNA polymerase sigma factor RpoE; Region: RpoE_Sigma70; TIGR02939
374930005068	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
374930005069	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial...; Region: Sigma70_r4; cd06171
374930005070	DNA binding residues [nucleotide binding]
374930005071	Flavinator of succinate dehydrogenase; Region: Sdh5; cl01110
374930005072	Large-conductance mechanosensitive channel, MscL; Region: MscL; cl00860
374930005073	potassium transporter peripheral membrane component; Reviewed; Region: trkA; PRK09496
374930005074	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
374930005075	Anion permease ArsB/NhaD.  These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life.  A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl09110
374930005076	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
374930005077	Anion permease ArsB/NhaD.  These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life.  A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl09110
374930005078	16S rRNA methyltransferase B; Provisional; Region: PRK10901
374930005079	N-terminal RNA binding domain of the methyltransferase Sun. The rRNA-specific 5-methylcytidine transferase Sun, also known as RrmB or Fmu shares the RNA-binding non-catalytic domain with the transcription termination factor NusB. The precise biological...; Region: Methyltransferase_Sun; cd00620
374930005080	putative RNA binding site [nucleotide binding]; other site
374930005081	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440
374930005082	S-adenosylmethionine binding site [chemical binding]; other site
374930005083	methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005
374930005084	Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646
374930005085	putative active site [active]
374930005086	substrate binding site [chemical binding]; other site
374930005087	putative cosubstrate binding site; other site
374930005088	catalytic site [active]
374930005089	C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704
374930005090	substrate binding site [chemical binding]; other site
374930005091	Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(...; Region: Pep_deformylase; cd00487
374930005092	active site
374930005093	catalytic residues [active]
374930005094	metal binding site [ion binding]; metal-binding site
374930005095	similar to hypothetical protein
374930005096	TfoX N-terminal domain; Region: TfoX_N; cl01167
374930005097	TfoX N-terminal domain; Region: TfoX_N; cl01167
374930005098	recombinase A; Provisional; Region: recA; PRK09354
374930005099	RecA is a  bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response.  RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983
374930005100	hexamer interface [polypeptide binding]; other site
374930005101	Walker A motif; other site
374930005102	ATP binding site [chemical binding]; other site
374930005103	Walker B motif; other site
374930005104	RecX family; Region: RecX; cl00936
374930005105	CrcB-like protein; Region: CRCB; cl09114
374930005106	potential frameshift: common BLAST hit: gi|68249196|ref|YP_248308.1| predicted hydrolase of the HAD superfamily [Haemophilus influenzae]
374930005107	potential frameshift: common BLAST hit: gi|68249197|ref|YP_248309.1| ornithine carbamoyltransferase [Haemophilus influenzae 86-028NP]
374930005108	AAK_CK: Carbamate kinase (CK) catalyzes both the ATP-phosphorylation of carbamate and carbamoyl phosphate (CP) utilization with the production of ATP from ADP and CP. Both CK (this CD) and nonhomologous CP synthetase synthesize carbamoyl phosphate, an...; Region: AAK_CK; cd04235
374930005109	carbamate kinase; Reviewed; Region: PRK09411
374930005110	putative substrate binding site [chemical binding]; other site
374930005111	nucleotide binding site [chemical binding]; other site
374930005112	nucleotide binding site [chemical binding]; other site
374930005113	homodimer interface [polypeptide binding]; other site
374930005114	Predicted membrane protein [Function unknown]; Region: COG1288
374930005115	Anion permease ArsB/NhaD.  These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life.  A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl09110