-- dump date   	20120504_145633
-- class       	Genbank::misc_feature
-- table       	misc_feature_note
-- id	note
656519000001	chromosomal replication initiation protein; Reviewed; Region: dnaA; PRK00149
656519000002	DnaA N-terminal domain; Region: DnaA_N; pfam11638
656519000003	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
656519000004	Walker A motif; other site
656519000005	ATP binding site [chemical binding]; other site
656519000006	Walker B motif; other site
656519000007	arginine finger; other site
656519000008	C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571
656519000009	DnaA box-binding interface [nucleotide binding]; other site
656519000010	DNA polymerase III subunit beta; Validated; Region: PRK05643
656519000011	Beta clamp domain.  The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria.  The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140
656519000012	putative DNA binding surface [nucleotide binding]; other site
656519000013	dimer interface [polypeptide binding]; other site
656519000014	beta-clamp/clamp loader binding surface; other site
656519000015	beta-clamp/translesion DNA polymerase binding surface; other site
656519000016	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cl09940
656519000017	recombination protein F; Reviewed; Region: recF; PRK00064
656519000018	RecF is a recombinational DNA repair ATPase that maintains replication in the presence of DNA damage.  When replication is prematurely disrupted by DNA damage, several recF pathway gene products play critical roles processing the arrested replication...; Region: ABC_RecF; cd03242
656519000019	Walker A/P-loop; other site
656519000020	ATP binding site [chemical binding]; other site
656519000021	Q-loop/lid; other site
656519000022	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
656519000023	ABC transporter signature motif; other site
656519000024	Walker B; other site
656519000025	D-loop; other site
656519000026	H-loop/switch region; other site
656519000027	DNA gyrase subunit B; Validated; Region: gyrB; PRK05644
656519000028	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
656519000029	ATP binding site [chemical binding]; other site
656519000030	Mg2+ binding site [ion binding]; other site
656519000031	G-X-G motif; other site
656519000032	TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822
656519000033	anchoring element; other site
656519000034	dimer interface [polypeptide binding]; other site
656519000035	ATP binding site [chemical binding]; other site
656519000036	TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366
656519000037	active site
656519000038	putative metal-binding site [ion binding]; other site
656519000039	DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986
656519000040	DNA gyrase subunit A; Validated; Region: PRK05560
656519000041	DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes in DNA...; Region: TOP4c; cd00187
656519000042	CAP-like domain; other site
656519000043	active site
656519000044	primary dimer interface [polypeptide binding]; other site
656519000045	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
656519000046	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
656519000047	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
656519000048	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
656519000049	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
656519000050	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
656519000051	glycerol kinase; Provisional; Region: glpK; PRK00047
656519000052	Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786
656519000053	N- and C-terminal domain interface [polypeptide binding]; other site
656519000054	active site
656519000055	MgATP binding site [chemical binding]; other site
656519000056	catalytic site [active]
656519000057	metal binding site [ion binding]; metal-binding site
656519000058	glycerol binding site [chemical binding]; other site
656519000059	homotetramer interface [polypeptide binding]; other site
656519000060	homodimer interface [polypeptide binding]; other site
656519000061	FBP binding site [chemical binding]; other site
656519000062	protein IIAGlc interface [polypeptide binding]; other site
656519000063	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
656519000064	Predicted dehydrogenase [General function prediction only]; Region: COG0579
656519000065	BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; cl01093
656519000066	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992
656519000067	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
656519000068	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
656519000069	intracellular protease, PfpI family; Region: PfpI; TIGR01382
656519000070	Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020
656519000071	conserved cys residue [active]
656519000072	Dihydroxyacetone kinase [Carbohydrate transport and metabolism]; Region: DAK1; COG2376
656519000073	dihydroxyacetone kinase subunit DhaK; Provisional; Region: PRK14481; cl10557
656519000074	DAK2 domain; Region: Dak2; cl03685
656519000075	PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cl00025
656519000076	Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349
656519000077	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
656519000078	DNA-binding site [nucleotide binding]; DNA binding site
656519000079	SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339
656519000080	Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105
656519000081	1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164
656519000082	putative substrate binding site [chemical binding]; other site
656519000083	putative ATP binding site [chemical binding]; other site
656519000084	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
656519000085	active site
656519000086	phosphorylation site [posttranslational modification]
656519000087	putative PTS system  transporter subunits IIBC; Provisional; Region: PRK11404
656519000088	PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569
656519000089	P-loop; other site
656519000090	active site
656519000091	phosphorylation site [posttranslational modification]
656519000092	Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; cl00557
656519000093	peptidylprolyl isomerase; Provisional; Region: prsA; PRK00059
656519000094	SurA N-terminal domain; Region: SurA_N_3; cl07813
656519000095	PPIC-type PPIASE domain; Region: Rotamase; cl08278
656519000096	Domain of unknown function (DUF2088); Region: DUF2088; cl15406
656519000097	seryl-tRNA synthetase; Provisional; Region: PRK05431
656519000098	Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403
656519000099	Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme bound...; Region: SerRS_core; cd00770
656519000100	dimer interface [polypeptide binding]; other site
656519000101	active site
656519000102	motif 1; other site
656519000103	motif 2; other site
656519000104	motif 3; other site
656519000105	2-keto-3-deoxy-6-phosphogluconate aldolase [Carbohydrate transport and metabolism]; Region: Eda; COG0800
656519000106	KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452
656519000107	active site
656519000108	intersubunit interface [polypeptide binding]; other site
656519000109	catalytic residue [active]
656519000110	2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166
656519000111	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
656519000112	substrate binding site [chemical binding]; other site
656519000113	ATP binding site [chemical binding]; other site
656519000114	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
656519000115	2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166
656519000116	substrate binding site [chemical binding]; other site
656519000117	ATP binding site [chemical binding]; other site
656519000118	ATP cone domain; Region: ATP-cone; pfam03477
656519000119	ribonucleoside-triphosphate reductase, adenosylcobalamin-dependent; Region: RTPR; TIGR02505
656519000120	Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939
656519000121	Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052
656519000122	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
656519000123	Site-specific recombinase XerD [DNA replication, recombination, and repair]; Region: XerD; COG4974
656519000124	phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189
656519000125	Int/Topo IB signature motif; other site
656519000126	Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600
656519000127	ParB-like nuclease domain; Region: ParBc; cl02129
656519000128	ParB-like partition proteins; Region: parB_part; TIGR00180
656519000129	Helix-turn-helix domains; Region: HTH; cl00088
656519000130	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
656519000131	DNA binding site [nucleotide binding]
656519000132	Int/Topo IB signature motif; other site
656519000133	active site
656519000134	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
656519000135	ABC transporter transmembrane region; Region: ABC_membrane; cl00549
656519000136	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
656519000137	Walker A/P-loop; other site
656519000138	ATP binding site [chemical binding]; other site
656519000139	Q-loop/lid; other site
656519000140	ABC transporter signature motif; other site
656519000141	Walker B; other site
656519000142	D-loop; other site
656519000143	H-loop/switch region; other site
656519000144	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
656519000145	active site
656519000146	nucleotide binding site [chemical binding]; other site
656519000147	HIGH motif; other site
656519000148	KMSKS motif; other site
656519000149	Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714
656519000150	Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377
656519000151	tetramer interface [polypeptide binding]; other site
656519000152	active site
656519000153	Mg2+/Mn2+ binding site [ion binding]; other site
656519000154	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
656519000155	phosphonopyruvate decarboxylase; Region: Ppyr-DeCO2ase; TIGR03297
656519000156	PYR/PP interface [polypeptide binding]; other site
656519000157	dimer interface [polypeptide binding]; other site
656519000158	TPP binding site [chemical binding]; other site
656519000159	Thiamine pyrophosphate (TPP) family, PpyrDC subfamily, TPP-binding module; composed of proteins similar to phosphonopyruvate decarboxylase (PpyrDC) proteins. PpyrDC is a homotrimeric enzyme which functions in the biosynthesis of C-P compounds such as...; Region: TPP_PpyrDC; cd03371
656519000160	TPP-binding site; other site
656519000161	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
656519000162	active site
656519000163	Hydroxyethylphosphoate dehydrogenase (HEPD) catalyzes the reduction of phosphonoacetaldehyde (PnAA) to hydroxyethylphosphoate (HEP); Region: HEPD; cd08182
656519000164	Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454
656519000165	putative active site [active]
656519000166	metal binding site [ion binding]; metal-binding site
656519000167	Helix-turn-helix domains; Region: HTH; cl00088
656519000168	putative transposase OrfB; Reviewed; Region: PHA02517
656519000169	HTH-like domain; Region: HTH_21; pfam13276
656519000170	Integrase core domain; Region: rve; cl01316
656519000171	Integrase core domain; Region: rve_3; cl15866
656519000172	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
656519000173	This family is most closely related to the GT1 family of glycosyltransferases. WabH in Klebsiella pneumoniae has been shown to transfer a GlcNAc residue from UDP-GlcNAc onto the acceptor GalUA residue in the cellular outer core; Region: GT1_WabH_like; cd03811
656519000174	putative ADP-binding pocket [chemical binding]; other site
656519000175	Helix-turn-helix domains; Region: HTH; cl00088
656519000176	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801
656519000177	HTH-like domain; Region: HTH_21; pfam13276
656519000178	Integrase core domain; Region: rve; cl01316
656519000179	Integrase core domain; Region: rve_3; cl15866
656519000180	Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826
656519000181	Helix-turn-helix domains; Region: HTH; cl00088
656519000182	Integrase core domain; Region: rve; cl01316
656519000183	Helix-turn-helix domains; Region: HTH; cl00088
656519000184	putative transposase OrfB; Reviewed; Region: PHA02517
656519000185	HTH-like domain; Region: HTH_21; pfam13276
656519000186	Integrase core domain; Region: rve; cl01316
656519000187	Integrase core domain; Region: rve_3; cl15866
656519000188	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
656519000189	This family is most closely related to the GT1 family of glycosyltransferases. WabH in Klebsiella pneumoniae has been shown to transfer a GlcNAc residue from UDP-GlcNAc onto the acceptor GalUA residue in the cellular outer core; Region: GT1_WabH_like; cd03811
656519000190	putative ADP-binding pocket [chemical binding]; other site
656519000191	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: APH_ChoK_like; cd05120
656519000192	active site
656519000193	ATP binding site [chemical binding]; other site
656519000194	This family is most closely related to the GT1 family of glycosyltransferases. WbnK in Shigella dysenteriae has been shown to be involved in the type 7 O-antigen biosynthesis; Region: GT1_WbnK_like; cd03807
656519000195	sugar transferase, PEP-CTERM/EpsH1 system associated; Region: stp2; TIGR03088
656519000196	putative ADP-binding pocket [chemical binding]; other site
656519000197	UDP-N-acetyl-D-mannosaminuronate dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: WecC; COG0677
656519000198	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
656519000199	UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984
656519000200	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
656519000201	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
656519000202	UDP glucuronic acid epimerase, extended (e) SDRs; Region: UDP_GE_SDE_e; cd05253
656519000203	putative NAD(P) binding site [chemical binding]; other site
656519000204	active site
656519000205	putative substrate binding site [chemical binding]; other site
656519000206	This family is most closely related to the GT1 family of glycosyltransferases. cap1E in Streptococcus pneumoniae is required for the synthesis of type 1 capsular polysaccharides; Region: GT1_cap1E_like; cd03808
656519000207	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
656519000208	putative ADP-binding pocket [chemical binding]; other site
656519000209	Bacterial sugar transferase; Region: Bac_transf; cl00939
656519000210	aminotransferase, LLPSF_NHT_00031 family; Region: NHT_00031; TIGR04181
656519000211	3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616
656519000212	inhibitor-cofactor binding pocket; inhibition site
656519000213	pyridoxal 5'-phosphate binding site [chemical binding]; other site
656519000214	catalytic residue [active]
656519000215	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
656519000216	DNA binding site [nucleotide binding]
656519000217	Int/Topo IB signature motif; other site
656519000218	active site
656519000219	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
656519000220	non-specific DNA binding site [nucleotide binding]; other site
656519000221	salt bridge; other site
656519000222	sequence-specific DNA binding site [nucleotide binding]; other site
656519000223	DNA primase, catalytic core; Region: dnaG; TIGR01391
656519000224	DNA primase, catalytic core; Region: dnaG; TIGR01391
656519000225	CHC2 zinc finger; Region: zf-CHC2; cl15369
656519000226	DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275
656519000227	TOPRIM_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of bacterial DnaG-type primases and their homologs. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_primases; cd01029
656519000228	active site
656519000229	metal binding site [ion binding]; metal-binding site
656519000230	interdomain interaction site; other site
656519000231	Protein of unknown function (DUF1232); Region: DUF1232; cl01318
656519000232	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
656519000233	G2 box; other site
656519000234	Switch I region; other site
656519000235	G3 box; other site
656519000236	Switch II region; other site
656519000237	Bacteriophage Mu Gam like protein; Region: Phage_Mu_Gam; cl01825
656519000238	RecT family; Region: RecT; cl04285
656519000239	Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071
656519000240	MPN+ (JAMM) motif; other site
656519000241	Zinc-binding site [ion binding]; other site
656519000242	Transposase, Mutator family; Region: Transposase_mut; pfam00872
656519000243	MULE transposase domain; Region: MULE; pfam10551
656519000244	anaerobic sulfatase-maturating enzyme; Region: sulfatase_rSAM; TIGR03942
656519000245	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
656519000246	FeS/SAM binding site; other site
656519000247	Domain of unknown function (DUF4008); Region: DUF4008; cl14869
656519000248	Predicted metal-binding protein related to the C-terminal domain of SecA [General function prediction only]; Region: COG3318
656519000249	SEC-C motif; Region: SEC-C; pfam02810
656519000250	Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659
656519000251	Sulfate transporter family; Region: Sulfate_transp; cl15842
656519000252	Sulfate transporter family; Region: Sulfate_transp; cl15842
656519000253	Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042
656519000254	Transposase domain (DUF772); Region: DUF772; cl15789
656519000255	Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119
656519000256	Sulfatase; Region: Sulfatase; cl10460
656519000257	Sodium:solute symporter family; Region: SSF; cl00456
656519000258	putative transporter; Provisional; Region: PRK10484
656519000259	Helix-turn-helix domains; Region: HTH; cl00088
656519000260	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
656519000261	FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121
656519000262	Predicted oxidoreductases (related to aryl-alcohol dehydrogenases) [Energy production and conversion]; Region: Tas; COG0667
656519000263	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
656519000264	active site
656519000265	catalytic tetrad [active]
656519000266	Acetamidase/Formamidase family; Region: FmdA_AmdA; cl01023
656519000267	Protein of unknown function (DUF328); Region: DUF328; cl01143
656519000268	cardiolipin synthetase; Reviewed; Region: cls; PRK01642
656519000269	Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396
656519000270	Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110
656519000271	putative active site [active]
656519000272	catalytic site [active]
656519000273	catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112
656519000274	putative active site [active]
656519000275	catalytic site [active]
656519000276	Transposase, Mutator family; Region: Transposase_mut; pfam00872
656519000277	MULE transposase domain; Region: MULE; pfam10551
656519000278	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
656519000279	dimer interface [polypeptide binding]; other site
656519000280	putative CheW interface [polypeptide binding]; other site
656519000281	Transposase domain (DUF772); Region: DUF772; cl15789
656519000282	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
656519000283	Transposase domain (DUF772); Region: DUF772; cl15789
656519000284	N-Utilization Substance G (NusG) N terminal (NGN) insert and Lin0431 are part of DUF1312; Region: DUF1312; cd09846
656519000285	5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt; cl00231
656519000286	ATP binding site [chemical binding]; other site
656519000287	active site
656519000288	substrate binding site [chemical binding]; other site
656519000289	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
656519000290	HSP70 interaction site [polypeptide binding]; other site
656519000291	Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534
656519000292	MatE; Region: MatE; cl10513
656519000293	MatE; Region: MatE; cl10513
656519000294	Deoxycytidylate deaminase domain. Deoxycytidylate deaminase catalyzes the deamination of dCMP to dUMP, providing the nucleotide substrate for thymidylate synthase. The enzyme binds Zn++, which is required for catalytic activity. The activity of the...; Region: deoxycytidylate_deaminase; cd01286
656519000295	catalytic motif [active]
656519000296	Zn binding site [ion binding]; other site
656519000297	Escherichia coli YaeB and related proteins; Region: UPF0066; cd09281
656519000298	homodimer interaction site [polypeptide binding]; other site
656519000299	cofactor binding site; other site
656519000300	ATP-grasp domain; Region: ATP-grasp_4; cl03087
656519000301	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
656519000302	Putative esterase; Region: Esterase; pfam00756
656519000303	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
656519000304	Helix-turn-helix domains; Region: HTH; cl00088
656519000305	FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121
656519000306	fructokinase; Reviewed; Region: PRK09557
656519000307	UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087
656519000308	UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247
656519000309	NAD binding site [chemical binding]; other site
656519000310	homodimer interface [polypeptide binding]; other site
656519000311	active site
656519000312	substrate binding site [chemical binding]; other site
656519000313	galactokinase; Provisional; Region: PRK05322
656519000314	Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509
656519000315	GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288
656519000316	GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544
656519000317	galactose-1-phosphate uridylyltransferase; Provisional; Region: PRK05270
656519000318	HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the basis...; Region: HIT_like; cl00228
656519000319	HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the basis...; Region: HIT_like; cl00228
656519000320	Predicted transcriptional regulator [Transcription]; Region: COG4189
656519000321	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
656519000322	dimerization interface [polypeptide binding]; other site
656519000323	putative DNA binding site [nucleotide binding]; other site
656519000324	putative Zn2+ binding site [ion binding]; other site
656519000325	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
656519000326	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
656519000327	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
656519000328	dimer interface [polypeptide binding]; other site
656519000329	conserved gate region; other site
656519000330	putative PBP binding loops; other site
656519000331	ABC-ATPase subunit interface; other site
656519000332	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
656519000333	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
656519000334	dimer interface [polypeptide binding]; other site
656519000335	conserved gate region; other site
656519000336	putative PBP binding loops; other site
656519000337	ABC-ATPase subunit interface; other site
656519000338	Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; cl08371
656519000339	Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703
656519000340	Cellulase (glycosyl hydrolase family 5); Region: Cellulase; cl15381
656519000341	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459
656519000342	PAS domain; Region: PAS_9; pfam13426
656519000343	PAS domain S-box; Region: sensory_box; TIGR00229
656519000344	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
656519000345	putative active site [active]
656519000346	heme pocket [chemical binding]; other site
656519000347	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
656519000348	metal binding site [ion binding]; metal-binding site
656519000349	active site
656519000350	I-site; other site
656519000351	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
656519000352	Zn2+ binding site [ion binding]; other site
656519000353	Mg2+ binding site [ion binding]; other site
656519000354	Domain of unknown function (DUF4126); Region: DUF4126; pfam13548
656519000355	Fasciclin domain; Region: Fasciclin; cl02663
656519000356	Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956
656519000357	active site
656519000358	intersubunit interactions; other site
656519000359	catalytic residue [active]
656519000360	PyridoxaL 5'-Phosphate Dependent Enzymes class IV (PLPDE_IV). This D-amino acid superfamily, one of five classes of PLPDE, consists of branched-chain amino acid aminotransferases (BCAT), D-amino acid transferases (DAAT), and 4-amino-4-deoxychorismate...; Region: PLPDE_IV; cd00449
656519000361	homodimer interface [polypeptide binding]; other site
656519000362	substrate-cofactor binding pocket; other site
656519000363	pyridoxal 5'-phosphate binding site [chemical binding]; other site
656519000364	catalytic residue [active]
656519000365	Anthranilate/para-aminobenzoate synthases component I [Amino acid transport and metabolism / Coenzyme metabolism]; Region: TrpE; COG0147
656519000366	Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715
656519000367	chorismate binding enzyme; Region: Chorismate_bind; cl10555
656519000368	para-aminobenzoate synthase component II; Provisional; Region: PRK08857
656519000369	Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743
656519000370	glutamine binding [chemical binding]; other site
656519000371	catalytic triad [active]
656519000372	H+/gluconate symporter and related permeases [Carbohydrate transport and metabolism / Amino acid transport and metabolism]; Region: GntT; COG2610
656519000373	Phosphosulfolactate phosphohydrolase and related enzymes [Coenzyme metabolism / General function prediction only]; Region: COG2045
656519000374	2-phosphosulpholactate phosphatase; Region: 2-ph_phosp; cl00895
656519000375	Transcriptional antiterminator [Transcription]; Region: BglG; COG3711
656519000376	Helix-turn-helix domains; Region: HTH; cl00088
656519000377	Helix-turn-helix domains; Region: HTH; cl00088
656519000378	PRD domain; Region: PRD; cl15445
656519000379	PRD domain; Region: PRD; cl15445
656519000380	PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568
656519000381	P-loop; other site
656519000382	active site
656519000383	phosphorylation site [posttranslational modification]
656519000384	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
656519000385	active site
656519000386	phosphorylation site [posttranslational modification]
656519000387	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
656519000388	active site
656519000389	phosphorylation site [posttranslational modification]
656519000390	PTS_IIB_galactitol: subunit IIB of enzyme II (EII) of the galactitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS).  In this system, EII is a galactitol-specific permease with two cytoplasmic domains (IIA and IIB) and a...; Region: PTS_IIB_galactitol; cd05566
656519000391	P-loop; other site
656519000392	active site
656519000393	phosphorylation site [posttranslational modification]
656519000394	PTS system sugar-specific permease component; Region: EIIC-GAT; cl04451
656519000395	Nitrogen regulatory protein P-II; Region: P-II; cl00412
656519000396	Nitrogen regulatory protein P-II; Region: P-II; smart00938
656519000397	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain [Transcription / Signal transduction mechanisms]; Region: PspF; COG1221
656519000398	Helix-turn-helix domains; Region: HTH; cl00088
656519000399	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
656519000400	Walker A motif; other site
656519000401	ATP binding site [chemical binding]; other site
656519000402	Walker B motif; other site
656519000403	arginine finger; other site
656519000404	Transcriptional antiterminator [Transcription]; Region: COG3933
656519000405	PRD domain; Region: PRD; cl15445
656519000406	PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006
656519000407	active pocket/dimerization site; other site
656519000408	active site
656519000409	phosphorylation site [posttranslational modification]
656519000410	Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367
656519000411	dimerization domain swap beta strand [polypeptide binding]; other site
656519000412	regulatory protein interface [polypeptide binding]; other site
656519000413	active site
656519000414	regulatory phosphorylation site [posttranslational modification]; other site
656519000415	PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564
656519000416	active site
656519000417	P-loop; other site
656519000418	phosphorylation site [posttranslational modification]
656519000419	cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592
656519000420	Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; cl00557
656519000421	PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215
656519000422	methionine cluster; other site
656519000423	active site
656519000424	phosphorylation site [posttranslational modification]
656519000425	metal binding site [ion binding]; metal-binding site
656519000426	Alpha-galactosidases/6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: CelF; COG1486
656519000427	Glycoside Hydrolases Family 4; Phospho-beta-glucosidase; Region: GH4_P_beta_glucosidase; cd05296
656519000428	NAD binding site [chemical binding]; other site
656519000429	sugar binding site [chemical binding]; other site
656519000430	divalent metal binding site [ion binding]; other site
656519000431	tetramer (dimer of dimers) interface [polypeptide binding]; other site
656519000432	dimer interface [polypeptide binding]; other site
656519000433	Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046
656519000434	haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282
656519000435	Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391
656519000436	active site
656519000437	motif I; other site
656519000438	motif II; other site
656519000439	Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391
656519000440	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
656519000441	ligand binding site [chemical binding]; other site
656519000442	CAT RNA binding domain; Region: CAT_RBD; cl03904
656519000443	transcriptional antiterminator BglG; Provisional; Region: PRK09772
656519000444	PRD domain; Region: PRD; cl15445
656519000445	PRD domain; Region: PRD; cl15445
656519000446	PTS system, N-acetylglucosamine-specific IIBC component; Region: PTS-II-BC-nag; TIGR01998
656519000447	Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; cl00557
656519000448	PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212
656519000449	active site turn [active]
656519000450	phosphorylation site [posttranslational modification]
656519000451	PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cl00162
656519000452	HPr interaction site; other site
656519000453	glycerol kinase (GK) interaction site [polypeptide binding]; other site
656519000454	active site
656519000455	phosphorylation site [posttranslational modification]
656519000456	GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399
656519000457	active site
656519000458	trimer interface [polypeptide binding]; other site
656519000459	allosteric site; other site
656519000460	active site lid [active]
656519000461	hexamer (dimer of trimers) interface [polypeptide binding]; other site
656519000462	N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820
656519000463	N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854
656519000464	active site
656519000465	dimer interface [polypeptide binding]; other site
656519000466	Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day.  Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN_family; cd02803
656519000467	mycofactocin system FadH/OYE family oxidoreductase 2; Region: mycofact_OYE_2; TIGR03997
656519000468	active site
656519000469	FMN binding site [chemical binding]; other site
656519000470	substrate binding site [chemical binding]; other site
656519000471	putative catalytic residue [active]
656519000472	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
656519000473	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
656519000474	Integrase core domain; Region: rve; cl01316
656519000475	DDE domain; Region: DDE_Tnp_IS240; pfam13610
656519000476	Integrase core domain; Region: rve_3; cl15866
656519000477	Cupin domain; Region: Cupin_2; cl09118
656519000478	Membrane transport protein; Region: Mem_trans; cl09117
656519000479	Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367
656519000480	dimerization domain swap beta strand [polypeptide binding]; other site
656519000481	regulatory protein interface [polypeptide binding]; other site
656519000482	active site
656519000483	regulatory phosphorylation site [posttranslational modification]; other site
656519000484	Transcriptional regulators [Transcription]; Region: GntR; COG1802
656519000485	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
656519000486	DNA-binding site [nucleotide binding]; DNA binding site
656519000487	FCD domain; Region: FCD; cl11656
656519000488	Transcriptional regulators [Transcription]; Region: GntR; COG1802
656519000489	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
656519000490	DNA-binding site [nucleotide binding]; DNA binding site
656519000491	FCD domain; Region: FCD; cl11656
656519000492	ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129
656519000493	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
656519000494	Walker A/P-loop; other site
656519000495	ATP binding site [chemical binding]; other site
656519000496	Q-loop/lid; other site
656519000497	ABC transporter signature motif; other site
656519000498	Walker B; other site
656519000499	D-loop; other site
656519000500	H-loop/switch region; other site
656519000501	This family represents domain II of the carbohydrate uptake proteins that transport only monosaccharides (Monos).  The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and hexoses; Region: ABC_Carb_Monos_II; cd03215
656519000502	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
656519000503	TM-ABC transporter signature motif; other site
656519000504	Periplasmic sugar-binding domain of the thermophilic Thermoanaerobacter tengcongensis ribose binding protein (ttRBP) and its mesophilic homologs; Region: PBP1_ribose_binding; cd06323
656519000505	Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407
656519000506	ligand binding site [chemical binding]; other site
656519000507	dimerization interface [polypeptide binding]; other site
656519000508	pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_y; TIGR03182
656519000509	Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000
656519000510	tetramer interface [polypeptide binding]; other site
656519000511	TPP-binding site [chemical binding]; other site
656519000512	heterodimer interface [polypeptide binding]; other site
656519000513	phosphorylation loop region [posttranslational modification]
656519000514	Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022
656519000515	Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036
656519000516	alpha subunit interface [polypeptide binding]; other site
656519000517	TPP binding site [chemical binding]; other site
656519000518	heterodimer interface [polypeptide binding]; other site
656519000519	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
656519000520	branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856
656519000521	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
656519000522	E3 interaction surface; other site
656519000523	lipoyl attachment site [posttranslational modification]; other site
656519000524	e3 binding domain; Region: E3_binding; pfam02817
656519000525	e3 binding domain; Region: E3_binding; pfam02817
656519000526	2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; cl02008
656519000527	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
656519000528	TM-ABC transporter signature motif; other site
656519000529	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
656519000530	TM-ABC transporter signature motif; other site
656519000531	Periplasmic sugar-binding domain of uncharacterized ABC-type transport systems; Region: PBP1_ABC_sugar_binding_like_8; cd06317
656519000532	Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407
656519000533	putative ligand binding site [chemical binding]; other site
656519000534	ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129
656519000535	This family represents the domain I of the carbohydrate uptake proteins that transport only monosaccharides (Monos).  The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and hexoses...; Region: ABC_Carb_Monos_I; cd03216
656519000536	Walker A/P-loop; other site
656519000537	ATP binding site [chemical binding]; other site
656519000538	Q-loop/lid; other site
656519000539	ABC transporter signature motif; other site
656519000540	Walker B; other site
656519000541	D-loop; other site
656519000542	H-loop/switch region; other site
656519000543	This family represents domain II of the carbohydrate uptake proteins that transport only monosaccharides (Monos).  The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and hexoses; Region: ABC_Carb_Monos_II; cd03215
656519000544	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
656519000545	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
656519000546	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; cl11611
656519000547	AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060
656519000548	Metal-binding active site; metal-binding site
656519000549	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
656519000550	classical (c) SDRs; Region: SDR_c; cd05233
656519000551	NAD(P) binding site [chemical binding]; other site
656519000552	active site
656519000553	Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006
656519000554	A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cd01066
656519000555	active site
656519000556	Coenzyme A acylating aldehyde dehydrogenase (ACDH), ALDH family 20-like; Region: ALDH_F20_ACDH; cd07122
656519000557	putative catalytic cysteine [active]
656519000558	succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696
656519000559	ATP-grasp domain; Region: ATP-grasp_4; cl03087
656519000560	CoA-ligase; Region: Ligase_CoA; cl02894
656519000561	succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678
656519000562	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
656519000563	CoA-ligase; Region: Ligase_CoA; cl02894
656519000564	dihydrolipoamide dehydrogenase; Region: lipoamide_DH; TIGR01350
656519000565	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
656519000566	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
656519000567	Malic enzyme, N-terminal domain; Region: malic; pfam00390
656519000568	NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311
656519000569	putative NAD(P) binding site [chemical binding]; other site
656519000570	Malic enzyme [Energy production and conversion]; Region: SfcA; COG0281
656519000571	Malic enzyme, N-terminal domain; Region: malic; pfam00390
656519000572	NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311
656519000573	putative NAD(P) binding site [chemical binding]; other site
656519000574	Domain of unknown function (DUF2088); Region: DUF2088; cl15406
656519000575	pyruvate phosphate dikinase; Provisional; Region: PRK09279
656519000576	Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326
656519000577	PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; cl01586
656519000578	Pyruvate kinase (PK):  Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl09155
656519000579	Domain of unknown function (DUF2437); Region: DUF2437; pfam10370
656519000580	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421
656519000581	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
656519000582	Ligand Binding Site [chemical binding]; other site
656519000583	Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412
656519000584	dimer interface [polypeptide binding]; other site
656519000585	substrate binding site [chemical binding]; other site
656519000586	metal binding sites [ion binding]; metal-binding site
656519000587	Protein of unknown function (DUF964); Region: DUF964; cl01483
656519000588	PAS fold; Region: PAS_4; pfam08448
656519000589	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
656519000590	putative active site [active]
656519000591	heme pocket [chemical binding]; other site
656519000592	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459
656519000593	PAS domain; Region: PAS_9; pfam13426
656519000594	PAS fold; Region: PAS_4; pfam08448
656519000595	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
656519000596	putative active site [active]
656519000597	heme pocket [chemical binding]; other site
656519000598	PAS domain S-box; Region: sensory_box; TIGR00229
656519000599	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
656519000600	putative active site [active]
656519000601	heme pocket [chemical binding]; other site
656519000602	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
656519000603	metal binding site [ion binding]; metal-binding site
656519000604	active site
656519000605	I-site; other site
656519000606	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
656519000607	Zn2+ binding site [ion binding]; other site
656519000608	Mg2+ binding site [ion binding]; other site
656519000609	Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367
656519000610	dimerization domain swap beta strand [polypeptide binding]; other site
656519000611	regulatory protein interface [polypeptide binding]; other site
656519000612	active site
656519000613	regulatory phosphorylation site [posttranslational modification]; other site
656519000614	GAF domain; Region: GAF; cl15785
656519000615	PAS fold; Region: PAS; pfam00989
656519000616	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
656519000617	putative active site [active]
656519000618	heme pocket [chemical binding]; other site
656519000619	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459
656519000620	PAS domain; Region: PAS_9; pfam13426
656519000621	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
656519000622	metal binding site [ion binding]; metal-binding site
656519000623	active site
656519000624	I-site; other site
656519000625	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
656519000626	Zn2+ binding site [ion binding]; other site
656519000627	Mg2+ binding site [ion binding]; other site
656519000628	Late competence development protein ComFB; Region: ComFB; pfam10719
656519000629	PAS domain; Region: PAS_9; pfam13426
656519000630	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
656519000631	PAS fold; Region: PAS_3; pfam08447
656519000632	putative active site [active]
656519000633	heme pocket [chemical binding]; other site
656519000634	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
656519000635	PAS fold; Region: PAS_3; pfam08447
656519000636	putative active site [active]
656519000637	heme pocket [chemical binding]; other site
656519000638	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
656519000639	metal binding site [ion binding]; metal-binding site
656519000640	active site
656519000641	I-site; other site
656519000642	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
656519000643	Zn2+ binding site [ion binding]; other site
656519000644	Mg2+ binding site [ion binding]; other site
656519000645	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054
656519000646	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
656519000647	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
656519000648	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
656519000649	dimer interface [polypeptide binding]; other site
656519000650	putative CheW interface [polypeptide binding]; other site
656519000651	PAS domain S-box; Region: sensory_box; TIGR00229
656519000652	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
656519000653	PAS fold; Region: PAS_3; pfam08447
656519000654	putative active site [active]
656519000655	heme pocket [chemical binding]; other site
656519000656	PAS domain S-box; Region: sensory_box; TIGR00229
656519000657	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
656519000658	putative active site [active]
656519000659	heme pocket [chemical binding]; other site
656519000660	PAS domain S-box; Region: sensory_box; TIGR00229
656519000661	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459
656519000662	PAS domain; Region: PAS_9; pfam13426
656519000663	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
656519000664	putative active site [active]
656519000665	heme pocket [chemical binding]; other site
656519000666	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
656519000667	dimer interface [polypeptide binding]; other site
656519000668	phosphorylation site [posttranslational modification]
656519000669	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
656519000670	ATP binding site [chemical binding]; other site
656519000671	Mg2+ binding site [ion binding]; other site
656519000672	G-X-G motif; other site
656519000673	Response regulator receiver domain; Region: Response_reg; pfam00072
656519000674	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
656519000675	active site
656519000676	phosphorylation site [posttranslational modification]
656519000677	intermolecular recognition site; other site
656519000678	dimerization interface [polypeptide binding]; other site
656519000679	Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane]; Region: Cfa; COG2230
656519000680	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
656519000681	S-adenosylmethionine binding site [chemical binding]; other site
656519000682	B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293
656519000683	B12 binding site [chemical binding]; other site
656519000684	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
656519000685	metal binding site [ion binding]; metal-binding site
656519000686	active site
656519000687	I-site; other site
656519000688	carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294
656519000689	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
656519000690	ATP-grasp domain; Region: ATP-grasp_4; cl03087
656519000691	Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787
656519000692	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
656519000693	ATP-grasp domain; Region: ATP-grasp_4; cl03087
656519000694	Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424
656519000695	IMP binding site; other site
656519000696	dimer interface [polypeptide binding]; other site
656519000697	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459
656519000698	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
656519000699	putative active site [active]
656519000700	heme pocket [chemical binding]; other site
656519000701	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459
656519000702	PAS fold; Region: PAS_3; pfam08447
656519000703	PAS domain S-box; Region: sensory_box; TIGR00229
656519000704	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
656519000705	putative active site [active]
656519000706	heme pocket [chemical binding]; other site
656519000707	GAF domain; Region: GAF; cl15785
656519000708	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
656519000709	metal binding site [ion binding]; metal-binding site
656519000710	active site
656519000711	I-site; other site
656519000712	PAS domain S-box; Region: sensory_box; TIGR00229
656519000713	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
656519000714	putative active site [active]
656519000715	heme pocket [chemical binding]; other site
656519000716	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
656519000717	metal binding site [ion binding]; metal-binding site
656519000718	active site
656519000719	I-site; other site
656519000720	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
656519000721	Zn2+ binding site [ion binding]; other site
656519000722	Mg2+ binding site [ion binding]; other site
656519000723	Uncharacterized conserved protein [Function unknown]; Region: COG4997
656519000724	Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174
656519000725	Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951
656519000726	Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120
656519000727	Glutamine amidotransferases class-II (GATase). The glutaminase domain catalyzes an amide nitrogen transfer from glutamine to the appropriate substrate. In this process, glutamine is hydrolyzed to glutamic acid and ammonia. This domain is related to...; Region: Gn_AT_II; cl00319
656519000728	Glutamine amidotransferases class-II (GATase). The glutaminase domain catalyzes an amide nitrogen transfer from glutamine to the appropriate substrate. In this process, glutamine is hydrolyzed to glutamic acid and ammonia. This domain is related to...; Region: Gn_AT_II; cl00319
656519000729	Glutamine amidotransferase domain; Region: GATase_6; pfam13522
656519000730	active site
656519000731	GXGXG domain. This domain of unknown function is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS),  in subunit C of tungsten formylmethanofuran dehydrogenase (FwdC) and in subunit C of molybdenum formylmethanofuran...; Region: GXGXG; cd00504
656519000732	domain_subunit interface; other site
656519000733	Glutamate synthase (GltS) FMN-binding domain.  GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808
656519000734	Conserved region in glutamate synthase; Region: Glu_synthase; pfam01645
656519000735	active site
656519000736	FMN binding site [chemical binding]; other site
656519000737	substrate binding site [chemical binding]; other site
656519000738	3Fe-4S cluster binding site [ion binding]; other site
656519000739	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cl00159
656519000740	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992
656519000741	Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459
656519000742	adenylylsulfate reductase subunit alpha; Validated; Region: PRK06854
656519000743	Fe-S-cluster-containing hydrogenase components 2 [Energy production and conversion]; Region: HycB; COG1142
656519000744	BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; cl01093
656519000745	Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665
656519000746	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
656519000747	This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function.  The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_6; cd06154
656519000748	homotrimer interaction site [polypeptide binding]; other site
656519000749	putative active site [active]
656519000750	Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239
656519000751	putative active site [active]
656519000752	catalytic site [active]
656519000753	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
656519000754	ATP binding site [chemical binding]; other site
656519000755	putative Mg++ binding site [ion binding]; other site
656519000756	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
656519000757	Superfamily II helicase, archaea-specific [General function prediction only]; Region: COG1202
656519000758	nucleotide binding region [chemical binding]; other site
656519000759	ATP-binding site [chemical binding]; other site
656519000760	HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the basis...; Region: HIT_like; cl00228
656519000761	nucleotide binding site/active site [active]
656519000762	HIT family signature motif; other site
656519000763	catalytic residue [active]
656519000764	Domain of unknown function (DUF4145); Region: DUF4145; pfam13643
656519000765	DNA phosphorothioation-dependent restriction protein DptF; Region: dnd_assoc_3; TIGR03238
656519000766	Helix-turn-helix domains; Region: HTH; cl00088
656519000767	Helix-turn-helix domains; Region: HTH; cl00088
656519000768	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3415
656519000769	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801
656519000770	HTH-like domain; Region: HTH_21; pfam13276
656519000771	Integrase core domain; Region: rve; cl01316
656519000772	Integrase core domain; Region: rve_3; cl15866
656519000773	DNA phosphorothioation-dependent restriction protein DptH; Region: dnd_assoc_2; TIGR03237
656519000774	Domain of unknown function DUF87; Region: DUF87; pfam01935
656519000775	AAA-like domain; Region: AAA_10; pfam12846
656519000776	Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177
656519000777	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
656519000778	minor groove reading motif; other site
656519000779	helix-hairpin-helix signature motif; other site
656519000780	substrate binding pocket [chemical binding]; other site
656519000781	active site
656519000782	Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; cl15304
656519000783	Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277
656519000784	putative active site [active]
656519000785	Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277
656519000786	putative active site [active]
656519000787	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl15754
656519000788	DNA-methyltransferase (dcm); Region: dcm; TIGR00675
656519000789	cofactor binding site; other site
656519000790	DNA binding site [nucleotide binding]
656519000791	substrate interaction site [chemical binding]; other site
656519000792	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl15754
656519000793	Loader and inhibitor of phage G40P; Region: Inhibitor_G39P; pfam11417
656519000794	YvrJ protein family; Region: YvrJ; pfam12841
656519000795	transposase; Provisional; Region: PRK06526
656519000796	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
656519000797	Walker A motif; other site
656519000798	ATP binding site [chemical binding]; other site
656519000799	Walker B motif; other site
656519000800	Helix-turn-helix domains; Region: HTH; cl00088
656519000801	HTH-like domain; Region: HTH_21; pfam13276
656519000802	Integrase core domain; Region: rve; cl01316
656519000803	Integrase core domain; Region: rve_3; cl15866
656519000804	Protein of unknown function (DUF2971); Region: DUF2971; pfam11185
656519000805	Protein of unknown function (DUF4238); Region: DUF4238; pfam14022
656519000806	hypothetical protein; Provisional; Region: PRK05590
656519000807	SEC-C motif; Region: SEC-C; pfam02810
656519000808	GAF domain; Region: GAF; cl15785
656519000809	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459
656519000810	PAS domain; Region: PAS_9; pfam13426
656519000811	Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain); Region: PAC; smart00086
656519000812	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
656519000813	PAS fold; Region: PAS_3; pfam08447
656519000814	putative active site [active]
656519000815	heme pocket [chemical binding]; other site
656519000816	GAF domain; Region: GAF; cl15785
656519000817	GAF domain; Region: GAF_2; pfam13185
656519000818	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
656519000819	c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206
656519000820	metal binding site [ion binding]; metal-binding site
656519000821	active site
656519000822	I-site; other site
656519000823	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
656519000824	Zn2+ binding site [ion binding]; other site
656519000825	Mg2+ binding site [ion binding]; other site
656519000826	Glycerol dehydrogenase and related enzymes [Energy production and conversion]; Region: GldA; COG0371
656519000827	Glycerol dehydrogenases (GlyDH) catalyzes oxidation of glycerol to dihydroxyacetone in glycerol dissmilation; Region: GlyDH; cd08170
656519000828	dimer interface [polypeptide binding]; other site
656519000829	active site
656519000830	metal binding site [ion binding]; metal-binding site
656519000831	2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959
656519000832	intersubunit interface [polypeptide binding]; other site
656519000833	active site
656519000834	catalytic residue [active]
656519000835	Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070
656519000836	uncharacterized xylulose kinase-like proteins, subgroup 2; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_XK_like_2; cd07805
656519000837	N- and C-terminal domain interface [polypeptide binding]; other site
656519000838	active site
656519000839	catalytic site [active]
656519000840	metal binding site [ion binding]; metal-binding site
656519000841	xylulose binding site [chemical binding]; other site
656519000842	ATP binding site [chemical binding]; other site
656519000843	putative homodimer interface [polypeptide binding]; other site
656519000844	Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383
656519000845	Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267
656519000846	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
656519000847	Lipase.  Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is 'interfacial activation', the process of becoming...; Region: Lipase; cl14883
656519000848	Predicted permeases [General function prediction only]; Region: COG0730; cl00498
656519000849	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
656519000850	ABC transporter transmembrane region; Region: ABC_membrane; cl00549
656519000851	MsbA is an essential ABC transporter, closely related to eukaryotic MDR proteins.  ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars, ions, peptides, and more complex organic...; Region: ABCC_MsbA; cd03251
656519000852	Walker A/P-loop; other site
656519000853	ATP binding site [chemical binding]; other site
656519000854	Q-loop/lid; other site
656519000855	ABC transporter signature motif; other site
656519000856	Walker B; other site
656519000857	D-loop; other site
656519000858	H-loop/switch region; other site
656519000859	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
656519000860	ABC transporter transmembrane region; Region: ABC_membrane; cl00549
656519000861	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
656519000862	Walker A/P-loop; other site
656519000863	ATP binding site [chemical binding]; other site
656519000864	Q-loop/lid; other site
656519000865	ABC transporter signature motif; other site
656519000866	Walker B; other site
656519000867	D-loop; other site
656519000868	H-loop/switch region; other site
656519000869	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
656519000870	dimerization interface [polypeptide binding]; other site
656519000871	putative DNA binding site [nucleotide binding]; other site
656519000872	putative Zn2+ binding site [ion binding]; other site
656519000873	Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826
656519000874	Helix-turn-helix domains; Region: HTH; cl00088
656519000875	Integrase core domain; Region: rve; cl01316
656519000876	Fibronectin type III-like domain; Region: Fn3-like; cl15273
656519000877	Fibronectin type III-like domain; Region: Fn3-like; cl15273
656519000878	Fibronectin type III-like domain; Region: Fn3-like; cl15273
656519000879	Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754
656519000880	Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753
656519000881	Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754
656519000882	Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754
656519000883	Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753
656519000884	Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754
656519000885	Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754
656519000886	Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753
656519000887	Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754
656519000888	Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754
656519000889	retinol dehydrogenase (retinol-DH), Light dependent Protochlorophyllide (Pchlide) OxidoReductase (LPOR) and related proteins, classical (c) SDRs; Region: retinol-DH_like_SDR_c_like; cd05327
656519000890	short chain dehydrogenase; Provisional; Region: PRK06197
656519000891	putative NAD(P) binding site [chemical binding]; other site
656519000892	active site
656519000893	PAS domain S-box; Region: sensory_box; TIGR00229
656519000894	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
656519000895	metal binding site [ion binding]; metal-binding site
656519000896	active site
656519000897	I-site; other site
656519000898	Probable transposase; Region: OrfB_IS605; pfam01385
656519000899	transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766
656519000900	Response regulator containing a CheY-like receiver domain and a GGDEF domain [Signal transduction mechanisms]; Region: PleD; COG3706
656519000901	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
656519000902	active site
656519000903	phosphorylation site [posttranslational modification]
656519000904	intermolecular recognition site; other site
656519000905	dimerization interface [polypeptide binding]; other site
656519000906	GAF domain; Region: GAF_2; pfam13185
656519000907	GAF domain; Region: GAF; cl15785
656519000908	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
656519000909	Zn2+ binding site [ion binding]; other site
656519000910	Mg2+ binding site [ion binding]; other site
656519000911	RNA:NAD 2'-phosphotransferase [Translation, ribosomal structure and biogenesis]; Region: KptA; COG1859
656519000912	RNA 2'-phosphotransferase, Tpt1 / KptA family; Region: PTS_2-RNA; pfam01885
656519000913	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
656519000914	catalytic core [active]
656519000915	branched-chain amino acid aminotransferase; Provisional; Region: PRK13357
656519000916	BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids  leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557
656519000917	homodimer interface [polypeptide binding]; other site
656519000918	substrate-cofactor binding pocket; other site
656519000919	catalytic residue [active]
656519000920	Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304
656519000921	Tetramer interface [polypeptide binding]; other site
656519000922	active site
656519000923	FMN-binding site [chemical binding]; other site
656519000924	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
656519000925	L-iditol 2-dehydrogenase; Region: iditol_2_DH_like; cd08235
656519000926	putative NAD(P) binding site [chemical binding]; other site
656519000927	catalytic Zn binding site [ion binding]; other site
656519000928	Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885
656519000929	anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188
656519000930	Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591
656519000931	ADP-ribosylglycohydrolase; Region: ADP_ribosyl_GH; cl00614
656519000932	ATP-dependent nuclease, subunit B [DNA replication, recombination, and repair]; Region: AddB; COG3857
656519000933	Inactivated superfamily I helicase [DNA replication, recombination, and repair]; Region: COG3893
656519000934	CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641
656519000935	putative recombination protein RecB; Provisional; Region: PRK13909
656519000936	CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641
656519000937	Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+.  Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262
656519000938	intersubunit interface [polypeptide binding]; other site
656519000939	Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+.  Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262
656519000940	ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121
656519000941	ABC component of the metal-type transporters.  This family includes transporters involved in the uptake of various metallic cations such as iron, manganese, and zinc.  The ATPases of this group of transporters are very similar to members of...; Region: ABC_Metallic_Cations; cd03235
656519000942	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
656519000943	ABC-ATPase subunit  interface; other site
656519000944	dimer interface [polypeptide binding]; other site
656519000945	putative PBP binding regions; other site
656519000946	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076
656519000947	Putative regulatory, ligand-binding protein related to C-terminal domains of K+ channels [Inorganic ion transport and metabolism]; Region: COG0490
656519000948	Anion permease ArsB/NhaD.  These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life.  A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl15357
656519000949	Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482
656519000950	Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999
656519000951	MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cl00399
656519000952	Domain of unknown function (DUF2007); Region: DUF2007; pfam09413
656519000953	Domain of unknown function DUF77; Region: DUF77; cl00307
656519000954	Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534
656519000955	MatE; Region: MatE; cl10513
656519000956	MatE; Region: MatE; cl10513
656519000957	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
656519000958	Helix-turn-helix domains; Region: HTH; cl00088
656519000959	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
656519000960	Helix-turn-helix domains; Region: HTH; cl00088
656519000961	This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE).  They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255
656519000962	putative bacteriocin export ABC transporter, lactococcin 972 group; Region: L_ocin_972_ABC; TIGR03608
656519000963	Walker A/P-loop; other site
656519000964	ATP binding site [chemical binding]; other site
656519000965	Q-loop/lid; other site
656519000966	ABC transporter signature motif; other site
656519000967	Walker B; other site
656519000968	D-loop; other site
656519000969	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
656519000970	ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591
656519000971	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
656519000972	FtsX-like permease family; Region: FtsX; cl15850
656519000973	Leucyl aminopeptidase (aminopeptidase T) [Amino acid transport and metabolism]; Region: AmpS; COG2309
656519000974	NAD(P)H:flavin oxidoreductase-like family 1.  A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes; Region: NADPH_oxidoreductase_1; cd02150
656519000975	putative FMN binding site [chemical binding]; other site
656519000976	Purine catabolism regulatory protein-like family; Region: PucR; pfam07905
656519000977	Sugar diacid utilization regulator [Transcription / Signal transduction mechanisms]; Region: CdaR; COG3835
656519000978	Helix-turn-helix domains; Region: HTH; cl00088
656519000979	Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518
656519000980	Protein of unknown function (DUF1177); Region: DUF1177; pfam06675
656519000981	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
656519000982	The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_7; cd08512
656519000983	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
656519000984	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427
656519000985	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173
656519000986	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
656519000987	dimer interface [polypeptide binding]; other site
656519000988	conserved gate region; other site
656519000989	ABC-ATPase subunit interface; other site
656519000990	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444
656519000991	The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE).  The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257
656519000992	Walker A/P-loop; other site
656519000993	ATP binding site [chemical binding]; other site
656519000994	Q-loop/lid; other site
656519000995	ABC transporter signature motif; other site
656519000996	Walker B; other site
656519000997	D-loop; other site
656519000998	H-loop/switch region; other site
656519000999	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
656519001000	dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308
656519001001	The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE).  The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257
656519001002	Walker A/P-loop; other site
656519001003	ATP binding site [chemical binding]; other site
656519001004	Q-loop/lid; other site
656519001005	ABC transporter signature motif; other site
656519001006	Walker B; other site
656519001007	D-loop; other site
656519001008	H-loop/switch region; other site
656519001009	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
656519001010	Predicted amidohydrolase [General function prediction only]; Region: COG0388
656519001011	Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cl11424
656519001012	active site
656519001013	catalytic triad [active]
656519001014	dimer interface [polypeptide binding]; other site
656519001015	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447
656519001016	nudix motif; other site
656519001017	Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to PFK family that includes ATP- and pyrophosphate (PPi)- dependent phosphofructokinases; Region: PFK; cl00204
656519001018	active site
656519001019	ADP/pyrophosphate binding site [chemical binding]; other site
656519001020	dimerization interface [polypeptide binding]; other site
656519001021	allosteric effector site; other site
656519001022	fructose-1,6-bisphosphate binding site; other site
656519001023	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl09108
656519001024	catalytic residue [active]
656519001025	Uncharacterized Fe-S protein [Energy production and conversion]; Region: COG1600
656519001026	Thermostable 8-oxoguanine DNA glycosylase [DNA replication, recombination, and repair]; Region: COG1059
656519001027	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
656519001028	putative beta-ketoacyl acyl carrier protein [ACP] reductase (BKR)-like, SDR; Region: BKR_like_SDR_like; cd05344
656519001029	putative NAD(P) binding site [chemical binding]; other site
656519001030	putative active site [active]
656519001031	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl09108
656519001032	catalytic residue [active]
656519001033	GAF domain; Region: GAF_2; pfam13185
656519001034	GAF domain; Region: GAF; cl15785
656519001035	Sugar diacid utilization regulator [Transcription / Signal transduction mechanisms]; Region: CdaR; COG3835
656519001036	Helix-turn-helix domains; Region: HTH; cl00088
656519001037	allantoate amidohydrolase; Reviewed; Region: PRK09290
656519001038	M20 Peptidase beta-alanine synthase, an amidohydrolase; Region: M20_bAS; cd03884
656519001039	active site
656519001040	metal binding site [ion binding]; metal-binding site
656519001041	dimer interface [polypeptide binding]; other site
656519001042	Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473
656519001043	M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_subfamily5; cd08019
656519001044	metal binding site [ion binding]; metal-binding site
656519001045	putative dimer interface [polypeptide binding]; other site
656519001046	Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473
656519001047	M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_subfamily5; cd08019
656519001048	metal binding site [ion binding]; metal-binding site
656519001049	putative dimer interface [polypeptide binding]; other site
656519001050	Alkyladenine DNA glycosylase catalyzes the first step in base excision repair; Region: AAG; cd00540
656519001051	active site
656519001052	DNA binding site [nucleotide binding]
656519001053	Aldose 1-epimerase, similar to Lactococcus lactis lacX; Region: Aldose_epim_lacX; cd09024
656519001054	active site
656519001055	catalytic residues [active]
656519001056	Zinc finger domain containing protein (CDGSH-type) [Function unknown]; Region: COG3369
656519001057	Iron-binding zinc finger CDGSH type; Region: zf-CDGSH; cl02748
656519001058	Iron-binding zinc finger CDGSH type; Region: zf-CDGSH; cl02748
656519001059	Cupin domain; Region: Cupin_2; cl09118
656519001060	Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726
656519001061	PAS fold; Region: PAS_4; pfam08448
656519001062	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
656519001063	PAS domain; Region: PAS_9; pfam13426
656519001064	putative active site [active]
656519001065	heme pocket [chemical binding]; other site
656519001066	PAS fold; Region: PAS; pfam00989
656519001067	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
656519001068	putative active site [active]
656519001069	heme pocket [chemical binding]; other site
656519001070	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459
656519001071	PAS fold; Region: PAS_3; pfam08447
656519001072	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
656519001073	metal binding site [ion binding]; metal-binding site
656519001074	active site
656519001075	I-site; other site
656519001076	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
656519001077	Zn2+ binding site [ion binding]; other site
656519001078	Mg2+ binding site [ion binding]; other site
656519001079	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
656519001080	PAS domain S-box; Region: sensory_box; TIGR00229
656519001081	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459
656519001082	putative diguanylate cyclase; Provisional; Region: PRK09776
656519001083	Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain); Region: PAC; smart00086
656519001084	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
656519001085	metal binding site [ion binding]; metal-binding site
656519001086	active site
656519001087	I-site; other site
656519001088	Peptidase family M48; Region: Peptidase_M48; cl12018
656519001089	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
656519001090	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
656519001091	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; cl11611
656519001092	DegT/DnrJ/EryC1/StrS aminotransferase family; Region: DegT_DnrJ_EryC1; pfam01041
656519001093	3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616
656519001094	inhibitor-cofactor binding pocket; inhibition site
656519001095	pyridoxal 5'-phosphate binding site [chemical binding]; other site
656519001096	catalytic residue [active]
656519001097	This family is the oxydase domain of NRPS (non-ribosomal peptide synthetase) and other proteins that modify polypeptides by cyclizing a thioester to form a ring. These include epoB, part of the epothilone biosynthesis pathway; tubD, part of the tubulysin...; Region: mcbC-like_oxidoreductase; cd02142
656519001098	putative FMN binding site [chemical binding]; other site
656519001099	NADPH bind site [chemical binding]; other site
656519001100	Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285
656519001101	nucleoside/Zn binding site; other site
656519001102	dimer interface [polypeptide binding]; other site
656519001103	catalytic motif [active]
656519001104	DNA polymerase III subunits gamma and tau; Validated; Region: PRK05563
656519001105	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
656519001106	Walker A motif; other site
656519001107	ATP binding site [chemical binding]; other site
656519001108	Walker B motif; other site
656519001109	arginine finger; other site
656519001110	DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169
656519001111	YbaB/EbfC DNA-binding family; Region: YbaB_DNA_bd; cl00494
656519001112	recombination protein RecR; Reviewed; Region: recR; PRK00076
656519001113	RecR protein; Region: RecR; pfam02132
656519001114	TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR.  RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025
656519001115	putative active site [active]
656519001116	putative metal-binding site [ion binding]; other site
656519001117	tetramer interface [polypeptide binding]; other site
656519001118	inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567
656519001119	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl09108
656519001120	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a key...; Region: CBS_pair_IMPDH; cd04601
656519001121	IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of the guanine...; Region: IMPDH; cd00381
656519001122	active site
656519001123	thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292
656519001124	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
656519001125	thymidylate kinase; Validated; Region: tmk; PRK00698
656519001126	Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672
656519001127	TMP-binding site; other site
656519001128	ATP-binding site [chemical binding]; other site
656519001129	Nitrogen regulatory protein P-II; Region: P-II; cl00412
656519001130	DNA polymerase III, delta subunit; Region: DNA_pol3_delta2; pfam13177
656519001131	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
656519001132	DNA polymerase III subunit delta'; Validated; Region: PRK07940
656519001133	PSP1 C-terminal conserved region; Region: PSP1; cl00770
656519001134	Protein of unknown function (DUF972); Region: DUF972; pfam06156
656519001135	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
656519001136	S-adenosylmethionine binding site [chemical binding]; other site
656519001137	Predicted methyltransferases [General function prediction only]; Region: COG0313
656519001138	Precorrin-3B methylase [Coenzyme metabolism]; Region: CobJ; cl00304
656519001139	methionyl-tRNA synthetase; Reviewed; Region: PRK12267
656519001140	catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814
656519001141	active site
656519001142	HIGH motif; other site
656519001143	KMSKS motif; other site
656519001144	Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957
656519001145	tRNA binding surface [nucleotide binding]; other site
656519001146	anticodon binding site; other site
656519001147	tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins.  This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties.  MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800
656519001148	dimer interface [polypeptide binding]; other site
656519001149	putative tRNA-binding site [nucleotide binding]; other site
656519001150	redox-sensing transcriptional repressor Rex; Provisional; Region: PRK05472
656519001151	Putative DNA-binding protein N-terminus; Region: Put_DNA-bind_N; pfam06971
656519001152	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
656519001153	Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446
656519001154	Uncharacterized conserved protein [Function unknown]; Region: COG1576; cl00679
656519001155	Predicted SPOUT methyltransferase; Region: SPOUT_MTase; pfam02590
656519001156	Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686
656519001157	Alanine dehydrogenase/PNT, N-terminal domain; Region: AlaDh_PNT_N; cl15379
656519001158	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
656519001159	alanine racemase; Reviewed; Region: alr; PRK00053
656519001160	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430
656519001161	active site
656519001162	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
656519001163	dimer interface [polypeptide binding]; other site
656519001164	substrate binding site [chemical binding]; other site
656519001165	catalytic residues [active]
656519001166	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
656519001167	OsmC-like protein; Region: OsmC; cl00767
656519001168	Predicted small molecule binding protein (contains 3H domain) [General function prediction only]; Region: COG1827
656519001169	Helix-turn-helix domains; Region: HTH; cl00088
656519001170	3H domain; Region: 3H; pfam02829
656519001171	Predicted symporter [General function prediction only]; Region: DhlC; COG4147
656519001172	Sodium:solute symporter family; Region: SSF; cl00456
656519001173	Quinolinate synthetase A protein; Region: NadA; cl00420
656519001174	Aspartate oxidase [Coenzyme metabolism]; Region: NadB; COG0029
656519001175	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
656519001176	Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910
656519001177	Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572
656519001178	nicotinate-nucleotide pyrophosphorylase; Region: nadC; TIGR00078
656519001179	dimerization interface [polypeptide binding]; other site
656519001180	active site
656519001181	Quinolinate synthetase A protein; Region: NadA; cl00420
656519001182	PAS domain S-box; Region: sensory_box; TIGR00229
656519001183	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
656519001184	PAS domain; Region: PAS_9; pfam13426
656519001185	putative active site [active]
656519001186	heme pocket [chemical binding]; other site
656519001187	PAS fold; Region: PAS_3; pfam08447
656519001188	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
656519001189	PAS fold; Region: PAS_3; pfam08447
656519001190	putative active site [active]
656519001191	heme pocket [chemical binding]; other site
656519001192	Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain); Region: PAC; smart00086
656519001193	GAF domain; Region: GAF; cl15785
656519001194	GAF domain; Region: GAF_2; pfam13185
656519001195	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
656519001196	metal binding site [ion binding]; metal-binding site
656519001197	active site
656519001198	I-site; other site
656519001199	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
656519001200	Zn2+ binding site [ion binding]; other site
656519001201	Mg2+ binding site [ion binding]; other site
656519001202	prephenate dehydratase; Provisional; Region: PRK11898
656519001203	Prephenate dehydratase; Region: PDT; pfam00800
656519001204	C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905
656519001205	putative L-Phe binding site [chemical binding]; other site
656519001206	3-deoxy-7-phosphoheptulonate synthase; Reviewed; Region: PRK08673
656519001207	NeuB family; Region: NeuB; cl00496
656519001208	Prephenate dehydrogenase [Amino acid transport and metabolism]; Region: TyrA; COG0287
656519001209	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
656519001210	EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556
656519001211	3-phosphoshikimate 1-carboxyvinyltransferase; Region: aroA; TIGR01356
656519001212	hinge; other site
656519001213	active site
656519001214	histidinol-phosphate aminotransferase; Validated; Region: PRK02731
656519001215	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
656519001216	pyridoxal 5'-phosphate binding site [chemical binding]; other site
656519001217	homodimer interface [polypeptide binding]; other site
656519001218	catalytic residue [active]
656519001219	3-deoxy-7-phosphoheptulonate synthase; Reviewed; Region: PRK08673
656519001220	NeuB family; Region: NeuB; cl00496
656519001221	Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304
656519001222	Tetramer interface [polypeptide binding]; other site
656519001223	active site
656519001224	FMN-binding site [chemical binding]; other site
656519001225	peptidylprolyl isomerase; Provisional; Region: prsA; PRK00059
656519001226	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
656519001227	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
656519001228	active site
656519001229	phosphorylation site [posttranslational modification]
656519001230	intermolecular recognition site; other site
656519001231	dimerization interface [polypeptide binding]; other site
656519001232	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
656519001233	DNA binding site [nucleotide binding]
656519001234	heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386
656519001235	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: VicK; COG5002
656519001236	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054
656519001237	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
656519001238	dimer interface [polypeptide binding]; other site
656519001239	phosphorylation site [posttranslational modification]
656519001240	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
656519001241	ATP binding site [chemical binding]; other site
656519001242	Mg2+ binding site [ion binding]; other site
656519001243	G-X-G motif; other site
656519001244	M18 Peptidase Aminopeptidase I; Region: M18_API; cd05659
656519001245	Aminopeptidase I zinc metalloprotease (M18); Region: Peptidase_M18; pfam02127
656519001246	oligomer interface [polypeptide binding]; other site
656519001247	putative active site [active]
656519001248	metal binding site [ion binding]; metal-binding site
656519001249	Glutaredoxin-like domain protein; Region: GlrX_arch; TIGR02187
656519001250	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
656519001251	Thioredoxin (TRX)-Glutaredoxin (GRX)-like family; composed of archaeal and bacterial proteins that show similarity to both TRX and GRX, including the C-terminal TRX-fold subdomain of Pyrococcus furiosus protein disulfide oxidoreductase (PfPDO). All...; Region: TRX_GRX_like; cd02973
656519001252	catalytic residues [active]
656519001253	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
656519001254	catalytic residues [active]
656519001255	NADPH-dependent FMN reductase; Region: FMN_red; cl00438
656519001256	Domain of unknown function (DUF1934); Region: DUF1934; cl01870
656519001257	arginyl-tRNA synthetase; Reviewed; Region: argS; PRK01611
656519001258	Arginyl tRNA synthetase N terminal domain; Region: Arg_tRNA_synt_N; cl04104
656519001259	catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671
656519001260	active site
656519001261	HIGH motif; other site
656519001262	KMSK motif region; other site
656519001263	Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956
656519001264	tRNA binding surface [nucleotide binding]; other site
656519001265	anticodon binding site; other site
656519001266	CTP synthetase; Validated; Region: pyrG; PRK05380
656519001267	CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113
656519001268	Catalytic site [active]
656519001269	active site
656519001270	UTP binding site [chemical binding]; other site
656519001271	Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746
656519001272	active site
656519001273	putative oxyanion hole; other site
656519001274	catalytic triad [active]
656519001275	Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024
656519001276	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
656519001277	substrate binding site [chemical binding]; other site
656519001278	oxyanion hole (OAH) forming residues; other site
656519001279	trimer interface [polypeptide binding]; other site
656519001280	hypothetical protein; Provisional; Region: PRK08185
656519001281	Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947
656519001282	intersubunit interface [polypeptide binding]; other site
656519001283	active site
656519001284	zinc binding site [ion binding]; other site
656519001285	Na+ binding site [ion binding]; other site
656519001286	Ca2+/Na+ antiporter [Inorganic ion transport and metabolism]; Region: ECM27; COG0530
656519001287	Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699
656519001288	Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699
656519001289	transcription termination factor Rho; Provisional; Region: rho; PRK09376
656519001290	Rho termination factor, N-terminal domain; Region: Rho_N; cl06505
656519001291	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
656519001292	RNA binding site [nucleotide binding]; other site
656519001293	Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128
656519001294	multimer interface [polypeptide binding]; other site
656519001295	Walker A motif; other site
656519001296	ATP binding site [chemical binding]; other site
656519001297	Walker B motif; other site
656519001298	Ribosomal protein L31; Region: Ribosomal_L31; cl00377
656519001299	thymidine kinase; Provisional; Region: PRK04296
656519001300	peptide chain release factor 1; Validated; Region: prfA; PRK00591
656519001301	RF-1 domain; Region: RF-1; cl02875
656519001302	RF-1 domain; Region: RF-1; cl02875
656519001303	N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328
656519001304	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
656519001305	S-adenosylmethionine binding site [chemical binding]; other site
656519001306	Telomere recombination; Region: Sua5_yciO_yrdC; cl00305
656519001307	Putative GTP-binding controlling metal-binding; Region: SUA5; pfam03481
656519001308	Low molecular weight phosphatase family; Region: LMWPc; cd00115
656519001309	Low molecular weight phosphotyrosine protein phosphatase; Region: LMWPc; pfam01451
656519001310	active site
656519001311	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
656519001312	active site
656519001313	UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472
656519001314	This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853
656519001315	Mg++ binding site [ion binding]; other site
656519001316	putative catalytic motif [active]
656519001317	substrate binding site [chemical binding]; other site
656519001318	ATP synthase A chain; Region: ATP-synt_A; cl00413
656519001319	ATP synthase subunit C; Region: ATP-synt_C; cl00466
656519001320	ATP synthase subunit C; Region: ATP-synt_C; cl00466
656519001321	Plant ATP synthase F0; Region: YMF19; cl07975
656519001322	F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711
656519001323	Plant ATP synthase F0; Region: YMF19; cl07975
656519001324	ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213
656519001325	F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281
656519001326	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; cl15275
656519001327	F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132
656519001328	beta subunit interaction interface [polypeptide binding]; other site
656519001329	Walker A motif; other site
656519001330	ATP binding site [chemical binding]; other site
656519001331	Walker B motif; other site
656519001332	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
656519001333	ATP synthase; Region: ATP-synt; cl00365
656519001334	F0F1 ATP synthase subunit gamma; Provisional; Region: PRK13422
656519001335	F0F1 ATP synthase subunit beta; Validated; Region: PRK09280
656519001336	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; cl15275
656519001337	F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133
656519001338	alpha subunit interaction interface [polypeptide binding]; other site
656519001339	Walker A motif; other site
656519001340	ATP binding site [chemical binding]; other site
656519001341	Walker B motif; other site
656519001342	inhibitor binding site; inhibition site
656519001343	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
656519001344	ATP synthase, Delta/Epsilon chain, beta-sandwich domain; Region: ATP-synt_DE_N; cl10033
656519001345	Protein of unknown function (DUF1694); Region: DUF1694; cl02318
656519001346	UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072
656519001347	UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555
656519001348	hinge; other site
656519001349	active site
656519001350	Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105
656519001351	1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164
656519001352	putative substrate binding site [chemical binding]; other site
656519001353	putative ATP binding site [chemical binding]; other site
656519001354	FOG: CBS domain [General function prediction only]; Region: COG0517
656519001355	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354
656519001356	Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482
656519001357	Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999
656519001358	rod shape-determining protein MreB; Provisional; Region: PRK13930
656519001359	Cell division protein FtsA; Region: FtsA; cl11496
656519001360	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2911
656519001361	Family of unknown function (DUF490); Region: DUF490; pfam04357
656519001362	Outer membrane protein/protective antigen OMA87 [Cell envelope biogenesis, outer membrane]; Region: COG4775
656519001363	Surface antigen variable number repeat; Region: Surf_Ag_VNR; cl10520
656519001364	Surface antigen variable number repeat; Region: Surf_Ag_VNR; cl10520
656519001365	Surface antigen; Region: Bac_surface_Ag; cl03097
656519001366	Outer membrane protein (OmpH-like); Region: OmpH; smart00935
656519001367	UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Provisional; Region: lpxD; PRK00892
656519001368	UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase, LpxD; Region: LpxD; pfam04613
656519001369	UDP-3-O-acyl-glucosamine N-acyltransferase (LpxD): The enzyme catalyzes the transfer of 3-hydroxymyristic acid or 3-hydroxy-arachidic acid, depending on the organism, from the acyl carrier protein (ACP) to UDP-3-O-acyl-glucosamine to produce UDP-2; Region: LbH_LpxD; cd03352
656519001370	trimer interface [polypeptide binding]; other site
656519001371	active site
656519001372	UDP-GlcNAc binding site [chemical binding]; other site
656519001373	lipid binding site [chemical binding]; lipid-binding site
656519001374	UDP-3-O-acyl-N-acetylglucosamine deacetylase [Cell envelope biogenesis, outer membrane]; Region: LpxC; cl00512
656519001375	UDP-3-O-acyl N-acetylglycosamine deacetylase; Region: LpxC; pfam03331
656519001376	FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288
656519001377	UDP-N-acetylglucosamine acyltransferase; Provisional; Region: PRK05289
656519001378	UDP-N-acetylglucosamine O-acyltransferase (UDP-GlcNAc acyltransferase): Proteins in this family catalyze the transfer of (R)-3-hydroxymyristic acid from its acyl carrier protein thioester to UDP-GlcNAc. It is the first enzyme in the lipid A biosynthetic...; Region: LbH_UDP-GlcNAc_AT; cd03351
656519001379	active site
656519001380	Protein of unknown function (DUF1009); Region: DUF1009; cl09182
656519001381	Lipid A disaccharide synthetase [Cell envelope biogenesis, outer membrane]; Region: LpxB; COG0763
656519001382	ipid-A-disaccharide synthase; Provisional; Region: PRK14089
656519001383	OstA-like protein; Region: OstA; cl00844
656519001384	Organic solvent tolerance protein OstA [Cell envelope biogenesis, outer membrane]; Region: Imp; COG1452
656519001385	ABC-type (unclassified) transport system, ATPase component [General function prediction only]; Region: YhbG; COG1137
656519001386	The ABC transporters belonging to the YhbG family are similar to members of the Mj1267_LivG family, which is involved in the transport of branched-chain amino acids. The genes yhbG and yhbN are located in a single operon and may function together in...; Region: ABC_YhbG; cd03218
656519001387	Walker A/P-loop; other site
656519001388	ATP binding site [chemical binding]; other site
656519001389	Q-loop/lid; other site
656519001390	ABC transporter signature motif; other site
656519001391	Walker B; other site
656519001392	D-loop; other site
656519001393	H-loop/switch region; other site
656519001394	Predicted permeases [General function prediction only]; Region: COG0795; cl12074
656519001395	Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739
656519001396	Protein of unknown function (DUF3084); Region: DUF3084; pfam11283
656519001397	Stage II sporulation protein R (spore_II_R); Region: Spore_II_R; cl09775
656519001398	chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168
656519001399	TATA element modulatory factor 1 DNA binding; Region: TMF_DNA_bd; pfam12329
656519001400	Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination.  HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD includes...; Region: RuvC_resolvase; cl00243
656519001401	S-layer homology domain; Region: SLH; pfam00395
656519001402	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl00284
656519001403	Outer membrane protein beta-barrel domain; Region: OMP_b-brl; cl01155
656519001404	Winged helix-turn helix; Region: HTH_29; pfam13551
656519001405	Helix-turn-helix domains; Region: HTH; cl00088
656519001406	Integrase core domain; Region: rve; cl01316
656519001407	S-layer homology domain; Region: SLH; pfam00395
656519001408	Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518
656519001409	aspartate racemase; Region: asp_race; TIGR00035
656519001410	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
656519001411	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587
656519001412	active site
656519001413	metal binding site [ion binding]; metal-binding site
656519001414	Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168
656519001415	Cation transport protein; Region: TrkH; cl10514
656519001416	S-layer homology domain; Region: SLH; pfam00395
656519001417	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459
656519001418	putative diguanylate cyclase; Provisional; Region: PRK09776
656519001419	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
656519001420	PAS domain; Region: PAS_9; pfam13426
656519001421	putative active site [active]
656519001422	heme pocket [chemical binding]; other site
656519001423	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
656519001424	PAS domain; Region: PAS_9; pfam13426
656519001425	putative active site [active]
656519001426	heme pocket [chemical binding]; other site
656519001427	GAF domain; Region: GAF; cl15785
656519001428	GAF domain; Region: GAF_2; pfam13185
656519001429	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
656519001430	metal binding site [ion binding]; metal-binding site
656519001431	active site
656519001432	I-site; other site
656519001433	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
656519001434	Zn2+ binding site [ion binding]; other site
656519001435	Mg2+ binding site [ion binding]; other site
656519001436	Leucine rich repeats (6 copies); Region: LRR_5; pfam13306
656519001437	Leucine rich repeats (6 copies); Region: LRR_5; pfam13306
656519001438	S-layer homology domain; Region: SLH; pfam00395
656519001439	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
656519001440	Probable transposase; Region: OrfB_IS605; pfam01385
656519001441	Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282
656519001442	Organic solvent tolerance protein OstA [Cell envelope biogenesis, outer membrane]; Region: Imp; COG1452
656519001443	This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...; Region: PGM2; cd05799
656519001444	active site
656519001445	substrate binding site [chemical binding]; other site
656519001446	metal binding site [ion binding]; metal-binding site
656519001447	Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752
656519001448	Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396
656519001449	nucleophile elbow; other site
656519001450	Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541
656519001451	active site
656519001452	tetramer interface; other site
656519001453	Uncharacterized Fe-S oxidoreductase [Energy production and conversion]; Region: COG1031
656519001454	Sporulation related domain; Region: SPOR; cl10051
656519001455	Stage II sporulation protein; Region: SpoIID; pfam08486
656519001456	Predicted periplasmic protein (DUF2233); Region: DUF2233; pfam09992
656519001457	Predicted periplasmic protein (DUF2233); Region: DUF2233; pfam09992
656519001458	RfaE encodes a bifunctional ADP-heptose synthase involved in the biosynthesis of the lipopolysaccharide (LPS) core precursor ADP-L-glycero-D-manno-heptose. LPS plays an important role in maintaining the structural integrity of the bacterial outer...; Region: RfaE_like; cd01172
656519001459	putative ribose interaction site [chemical binding]; other site
656519001460	putative ADP binding site [chemical binding]; other site
656519001461	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
656519001462	Cytidylyltransferase; Region: CTP_transf_2; pfam01467
656519001463	active site
656519001464	nucleotide binding site [chemical binding]; other site
656519001465	HIGH motif; other site
656519001466	KMSKS motif; other site
656519001467	RNA polymerase factor sigma-70; Validated; Region: PRK08295
656519001468	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
656519001469	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761
656519001470	Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040
656519001471	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
656519001472	active site
656519001473	RaiA ('ribosome-associated inhibitor A', also known as Protein Y (PY), YfiA, and SpotY,  is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal A site; Region: RaiA; cd00552
656519001474	30S subunit binding site; other site
656519001475	Protein of unknown function (DUF3442); Region: DUF3442; pfam11924
656519001476	Bacterial Ig-like domain (group 4); Region: Big_4; pfam07532
656519001477	Peptidase S8 family domain in Thermitase-like proteins; Region: Peptidases_S8_Thermitase_like; cd07484
656519001478	active site
656519001479	catalytic triad [active]
656519001480	Predicted permeases [General function prediction only]; Region: COG0795; cl12074
656519001481	Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739
656519001482	Organic solvent tolerance protein OstA [Cell envelope biogenesis, outer membrane]; Region: Imp; COG1452
656519001483	Lipopolysaccharide-assembly, LptC-related; Region: LptC; pfam06835
656519001484	OstA-like protein; Region: OstA; cl00844
656519001485	Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cl11424
656519001486	active site
656519001487	catalytic triad [active]
656519001488	dimer interface [polypeptide binding]; other site
656519001489	Na+/H+ antiporter NhaC; Region: antiport_nhaC; TIGR00931
656519001490	C4-dicarboxylate anaerobic carrier; Region: DcuC; cl15356
656519001491	Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446
656519001492	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
656519001493	metal binding site [ion binding]; metal-binding site
656519001494	active site
656519001495	I-site; other site
656519001496	preprotein translocase subunit SecA; Reviewed; Region: PRK12904
656519001497	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
656519001498	SecA preprotein cross-linking domain; Region: SecA_PP_bind; cl03078
656519001499	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
656519001500	nucleotide binding region [chemical binding]; other site
656519001501	ATP-binding site [chemical binding]; other site
656519001502	peptide chain release factor 2; Validated; Region: prfB; PRK00578
656519001503	RF-1 domain; Region: RF-1; cl02875
656519001504	RF-1 domain; Region: RF-1; cl02875
656519001505	Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; cl09156
656519001506	The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533
656519001507	Uncharacterized conserved protein [Function unknown]; Region: COG1284
656519001508	Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588
656519001509	Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588
656519001510	Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; cl10498
656519001511	Periplasmic protease [Cell envelope biogenesis, outer membrane]; Region: Prc; COG0793
656519001512	C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526
656519001513	PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988
656519001514	protein binding site [polypeptide binding]; other site
656519001515	C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560
656519001516	Catalytic dyad [active]
656519001517	L-serine dehydratase, iron-sulfur-dependent, beta subunit; Region: sda_beta; TIGR00719
656519001518	Serine dehydratase beta chain; Region: SDH_beta; pfam03315
656519001519	C-terminal ACT domain of the L-serine dehydratase (LSD), iron-sulfur-dependent, beta subunit; Region: ACT_LSD; cd04903
656519001520	putative L-serine binding site [chemical binding]; other site
656519001521	L-serine deaminase [Amino acid transport and metabolism]; Region: SdaA; COG1760
656519001522	Serine dehydratase alpha chain; Region: SDH_alpha; cl12120
656519001523	Photosynthetic reaction center (RC) complex, subunit H;  RC is an integral membrane protein-pigment complex which catalyzes light-induced reduction of ubiquinone to ubiquinol, generating a transmembrane electrochemical gradient of protons used to produce...; Region: PRCH; cl09959
656519001524	excinuclease ABC subunit B; Provisional; Region: PRK05298
656519001525	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
656519001526	ATP binding site [chemical binding]; other site
656519001527	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
656519001528	nucleotide binding region [chemical binding]; other site
656519001529	ATP-binding site [chemical binding]; other site
656519001530	Ultra-violet resistance protein B; Region: UvrB; pfam12344
656519001531	excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349
656519001532	The excision repair protein UvrA domain I; Nucleotide excision repair in eubacteria is a process that repairs DNA damage by the removal of a 12-13-mer oligonucleotide containing the lesion.  Recognition and cleavage of the damaged DNA is a multistep...; Region: ABC_UvrA_I; cd03270
656519001533	The excision repair protein UvrA domain I; Nucleotide excision repair in eubacteria is a process that repairs DNA damage by the removal of a 12-13-mer oligonucleotide containing the lesion.  Recognition and cleavage of the damaged DNA is a multistep...; Region: ABC_UvrA_I; cd03270
656519001534	The excision repair protein UvrA domain II; Nucleotide excision repair in eubacteria is a process that repairs DNA damage by the removal of a 12-13-mer oligonucleotide containing the lesion.  Recognition and cleavage of the damaged DNA is a multistep...; Region: ABC_UvrA_II; cd03271
656519001535	The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709
656519001536	The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995
656519001537	glutathione ABC transporter permease GsiC; Provisional; Region: PRK15081
656519001538	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
656519001539	dimer interface [polypeptide binding]; other site
656519001540	conserved gate region; other site
656519001541	ABC-ATPase subunit interface; other site
656519001542	N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911
656519001543	Uncharacterized protein related to plant photosystem II stability/assembly factor [General function prediction only]; Region: COG4447
656519001544	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
656519001545	dimer interface [polypeptide binding]; other site
656519001546	conserved gate region; other site
656519001547	putative PBP binding loops; other site
656519001548	ABC-ATPase subunit interface; other site
656519001549	ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123
656519001550	The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE).  The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257
656519001551	Walker A/P-loop; other site
656519001552	ATP binding site [chemical binding]; other site
656519001553	Q-loop/lid; other site
656519001554	ABC transporter signature motif; other site
656519001555	Walker B; other site
656519001556	D-loop; other site
656519001557	H-loop/switch region; other site
656519001558	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
656519001559	The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE).  The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257
656519001560	Walker A/P-loop; other site
656519001561	ATP binding site [chemical binding]; other site
656519001562	Q-loop/lid; other site
656519001563	ABC transporter signature motif; other site
656519001564	Walker B; other site
656519001565	D-loop; other site
656519001566	H-loop/switch region; other site
656519001567	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
656519001568	Glycerol-3-phosphate responsive antiterminator; Region: G3P_antiterm; cl00852
656519001569	Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584
656519001570	Glycerophosphodiester phosphodiesterase domain of Thermoanaerobacter tengcongensis and similar proteins; Region: GDPD_TtGDE_like; cd08563
656519001571	active site
656519001572	catalytic site [active]
656519001573	metal binding site [ion binding]; metal-binding site
656519001574	dimer interface [polypeptide binding]; other site
656519001575	TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638
656519001576	Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441
656519001577	Tripartite ATP-independent periplasmic transporters, DctQ component; Region: DctQ; cl01181
656519001578	DctM-like transporters; Region: DctM; pfam06808
656519001579	C4-dicarboxylate anaerobic carrier; Region: DcuC; cl15356
656519001580	MgtC family; Region: MgtC; pfam02308
656519001581	Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584
656519001582	Glycerophosphodiester phosphodiesterase domain of Thermoanaerobacter tengcongensis and similar proteins; Region: GDPD_TtGDE_like; cd08563
656519001583	active site
656519001584	catalytic site [active]
656519001585	metal binding site [ion binding]; metal-binding site
656519001586	dimer interface [polypeptide binding]; other site
656519001587	Transposase IS200 like; Region: Y1_Tnp; cl00848
656519001588	Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; cl00557
656519001589	Response regulator containing CheY-like receiver and SARP domains [Signal transduction mechanisms]; Region: COG3947
656519001590	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl09944
656519001591	active site
656519001592	phosphorylation site [posttranslational modification]
656519001593	intermolecular recognition site; other site
656519001594	dimerization interface [polypeptide binding]; other site
656519001595	Helix-turn-helix domains; Region: HTH; cl00088
656519001596	excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558
656519001597	Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434
656519001598	GIY-YIG motif/motif A; other site
656519001599	active site
656519001600	catalytic site [active]
656519001601	putative DNA binding site [nucleotide binding]; other site
656519001602	metal binding site [ion binding]; metal-binding site
656519001603	UvrB/uvrC motif; Region: UVR; pfam02151
656519001604	UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459
656519001605	Glutaredoxin (GRX) family, GRX bacterial class 1 and 3 (b_1_3)-like subfamily; composed of bacterial GRXs, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, catalyzing the...; Region: GRX_GRXb_1_3_like; cd03418
656519001606	GSH binding site [chemical binding]; other site
656519001607	catalytic residues [active]
656519001608	thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292
656519001609	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
656519001610	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
656519001611	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
656519001612	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
656519001613	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; cl11611
656519001614	galactose-1-phosphate uridylyltransferase; Provisional; Region: PRK05270
656519001615	HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the basis...; Region: HIT_like; cl00228
656519001616	HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the basis...; Region: HIT_like; cl00228
656519001617	Transcriptional regulators [Transcription]; Region: GntR; COG1802
656519001618	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
656519001619	DNA-binding site [nucleotide binding]; DNA binding site
656519001620	FCD domain; Region: FCD; cl11656
656519001621	c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206
656519001622	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
656519001623	Zn2+ binding site [ion binding]; other site
656519001624	Mg2+ binding site [ion binding]; other site
656519001625	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
656519001626	PAS domain; Region: PAS_9; pfam13426
656519001627	putative active site [active]
656519001628	heme pocket [chemical binding]; other site
656519001629	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
656519001630	metal binding site [ion binding]; metal-binding site
656519001631	active site
656519001632	I-site; other site
656519001633	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
656519001634	Zn2+ binding site [ion binding]; other site
656519001635	Mg2+ binding site [ion binding]; other site
656519001636	PAS domain; Region: PAS_9; pfam13426
656519001637	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
656519001638	PAS fold; Region: PAS_3; pfam08447
656519001639	putative active site [active]
656519001640	heme pocket [chemical binding]; other site
656519001641	two-component VirA-like sensor kinase; Provisional; Region: PRK13837
656519001642	Protein of unknown function (DUF3442); Region: DUF3442; pfam11924
656519001643	The GLUG motif; Region: Glug; pfam07581
656519001644	Glycerate kinase family; Region: Gly_kinase; cl00841
656519001645	glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750
656519001646	Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713
656519001647	active site
656519001648	dimer interface [polypeptide binding]; other site
656519001649	Glutamate synthase central domain; Region: Glu_syn_central; pfam04898
656519001650	Glutamate synthase (GltS) FMN-binding domain.  GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808
656519001651	active site
656519001652	FMN binding site [chemical binding]; other site
656519001653	substrate binding site [chemical binding]; other site
656519001654	3Fe-4S cluster binding site [ion binding]; other site
656519001655	gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982
656519001656	domain interface; other site
656519001657	glutamate synthase subunit beta; Reviewed; Region: gltD; PRK12810
656519001658	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
656519001659	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
656519001660	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
656519001661	substrate binding pocket [chemical binding]; other site
656519001662	membrane-bound complex binding site; other site
656519001663	hinge residues; other site
656519001664	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427
656519001665	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
656519001666	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
656519001667	HisP and GlnQ are the ATP-binding components of the bacterial periplasmic histidine and glutamine permeases, repectively.  Histidine permease is a multisubunit complex containing the HisQ and HisM integral membrane subunits and two copies of HisP.  HisP...; Region: ABC_HisP_GlnQ_permeases; cd03262
656519001668	Walker A/P-loop; other site
656519001669	ATP binding site [chemical binding]; other site
656519001670	Q-loop/lid; other site
656519001671	ABC transporter signature motif; other site
656519001672	Walker B; other site
656519001673	D-loop; other site
656519001674	H-loop/switch region; other site
656519001675	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
656519001676	dimer interface [polypeptide binding]; other site
656519001677	conserved gate region; other site
656519001678	putative PBP binding loops; other site
656519001679	ABC-ATPase subunit interface; other site
656519001680	FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277
656519001681	FAD binding domain; Region: FAD_binding_4; pfam01565
656519001682	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
656519001683	putative substrate translocation pore; other site
656519001684	The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714
656519001685	Ligand binding site [chemical binding]; other site
656519001686	Electron transfer flavoprotein domain; Region: ETF; pfam01012
656519001687	Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025
656519001688	The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715
656519001689	Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766
656519001690	2-deoxy-D-gluconate 3-dehydrogenase; Provisional; Region: PRK06935
656519001691	gluconate 5-dehydrogenase (Ga5DH)-like, classical (c) SDRs; Region: Ga5DH-like_SDR_c; cd05347
656519001692	NADP binding site [chemical binding]; other site
656519001693	homodimer interface [polypeptide binding]; other site
656519001694	active site
656519001695	Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070
656519001696	FGGY family of carbohydrate kinases; Region: FGGY; cl08364
656519001697	catalytic site [active]
656519001698	metal binding site [ion binding]; metal-binding site
656519001699	carbohydrate binding site [chemical binding]; other site
656519001700	FGGY family of carbohydrate kinases; Region: FGGY; cl08364
656519001701	active site
656519001702	MgATP binding site [chemical binding]; other site
656519001703	metal binding site [ion binding]; metal-binding site
656519001704	BCCT family transporter; Region: BCCT; cl00569
656519001705	Survival protein SurE; Region: SurE; cl00448
656519001706	SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS; cl00389
656519001707	Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: COG4667
656519001708	Hypothetical patatin similar to yjju protein of Escherichia coli; Region: Pat_hypo_Ecoli_yjju_like; cd07208
656519001709	active site
656519001710	nucleophile elbow; other site
656519001711	Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893
656519001712	active site
656519001713	catalytic site [active]
656519001714	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
656519001715	Response regulator receiver domain; Region: Response_reg; pfam00072
656519001716	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
656519001717	active site
656519001718	phosphorylation site [posttranslational modification]
656519001719	intermolecular recognition site; other site
656519001720	dimerization interface [polypeptide binding]; other site
656519001721	Histidine kinase; Region: His_kinase; pfam06580
656519001722	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
656519001723	ATP binding site [chemical binding]; other site
656519001724	Mg2+ binding site [ion binding]; other site
656519001725	G-X-G motif; other site
656519001726	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
656519001727	metal binding site [ion binding]; metal-binding site
656519001728	active site
656519001729	I-site; other site
656519001730	Response regulator containing CheY-like receiver and SARP domains [Signal transduction mechanisms]; Region: COG3947
656519001731	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
656519001732	active site
656519001733	phosphorylation site [posttranslational modification]
656519001734	intermolecular recognition site; other site
656519001735	dimerization interface [polypeptide binding]; other site
656519001736	Helix-turn-helix domains; Region: HTH; cl00088
656519001737	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
656519001738	active site
656519001739	phosphorylation site [posttranslational modification]
656519001740	intermolecular recognition site; other site
656519001741	dimerization interface [polypeptide binding]; other site
656519001742	Fibronectin type III-like domain; Region: Fn3-like; cl15273
656519001743	Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383
656519001744	FecR protein; Region: FecR; pfam04773
656519001745	putative diguanylate cyclase; Provisional; Region: PRK09776
656519001746	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459
656519001747	PAS domain; Region: PAS_9; pfam13426
656519001748	GAF domain; Region: GAF; cl15785
656519001749	GAF domain; Region: GAF_2; pfam13185
656519001750	PAS domain S-box; Region: sensory_box; TIGR00229
656519001751	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459
656519001752	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
656519001753	metal binding site [ion binding]; metal-binding site
656519001754	active site
656519001755	I-site; other site
656519001756	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
656519001757	Zn2+ binding site [ion binding]; other site
656519001758	Mg2+ binding site [ion binding]; other site
656519001759	putative transposase OrfB; Reviewed; Region: PHA02517
656519001760	HTH-like domain; Region: HTH_21; pfam13276
656519001761	Integrase core domain; Region: rve; cl01316
656519001762	Integrase core domain; Region: rve_3; cl15866
656519001763	Helix-turn-helix domains; Region: HTH; cl00088
656519001764	Bulb-type mannose-specific lectin. The domain contains a three-fold internal repeat (beta-prism architecture). The consensus sequence motif QXDXNXVXY is involved in alpha-D-mannose recognition. Lectins are carbohydrate-binding proteins which specifically...; Region: B_lectin; cl00039
656519001765	Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700
656519001766	Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669
656519001767	FOG: WD40-like repeat [Function unknown]; Region: COG1520
656519001768	RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651
656519001769	Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078
656519001770	putative active site [active]
656519001771	putative NTP binding site [chemical binding]; other site
656519001772	putative nucleic acid binding site [nucleotide binding]; other site
656519001773	Group II intron, maturase-specific domain; Region: GIIM; pfam08388
656519001774	Protein of unknown function (DUF3442); Region: DUF3442; pfam11924
656519001775	The GLUG motif; Region: Glug; pfam07581
656519001776	Helix-turn-helix domains; Region: HTH; cl00088
656519001777	putative transposase OrfB; Reviewed; Region: PHA02517
656519001778	HTH-like domain; Region: HTH_21; pfam13276
656519001779	Integrase core domain; Region: rve; cl01316
656519001780	Integrase core domain; Region: rve_3; cl15866
656519001781	capsular exopolysaccharide family; Region: eps_fam; TIGR01007
656519001782	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
656519001783	Chain length determinant protein; Region: Wzz; cl15801
656519001784	polysaccharide chain length determinant protein, PEP-CTERM locus subfamily; Region: pepcterm_ChnLen; TIGR03007
656519001785	Chain length determinant protein; Region: Wzz; cl15801
656519001786	Chain length determinant protein; Region: Wzz; cl15801
656519001787	Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563
656519001788	putative polysaccharide export protein, PEP-CTERM sytem-associated; Region: pepcterm_export; TIGR03027
656519001789	SLBB domain; Region: SLBB; pfam10531
656519001790	polysaccharide export protein EpsE; Region: EpsE; TIGR03028
656519001791	SLBB domain; Region: SLBB; pfam10531
656519001792	Capsular polysaccharide biosynthesis protein [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: CapC; COG4464
656519001793	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cl02931
656519001794	hypothetical protein; Provisional; Region: PRK05590
656519001795	SEC-C motif; Region: SEC-C; pfam02810
656519001796	Propionate catabolism activator; Region: PrpR_N; pfam06506
656519001797	Transcriptional regulator containing PAS, AAA-type ATPase, and DNA-binding domains [Transcription / Signal transduction mechanisms]; Region: RocR; COG3829
656519001798	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459
656519001799	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
656519001800	Walker A motif; other site
656519001801	ATP binding site [chemical binding]; other site
656519001802	Walker B motif; other site
656519001803	arginine finger; other site
656519001804	Helix-turn-helix domains; Region: HTH; cl00088
656519001805	Protein of unknown function, DUF1537; Region: DUF1537; cl01345
656519001806	Pyridoxal phosphate biosynthetic protein PdxA; Region: PdxA; cl00873
656519001807	4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK03743
656519001808	Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329
656519001809	Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408
656519001810	inhibitor site; inhibition site
656519001811	active site
656519001812	dimer interface [polypeptide binding]; other site
656519001813	catalytic residue [active]
656519001814	Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454
656519001815	5-hydroxyvalerate dehydrogenase (HVD) catalyzes the oxidation of 5-hydroxyvalerate to 5-oxovalerate with NAD+ as cofactor; Region: HVD; cd08193
656519001816	putative active site [active]
656519001817	metal binding site [ion binding]; metal-binding site
656519001818	Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441
656519001819	Tripartite ATP-independent periplasmic transporters, DctQ component; Region: DctQ; cl01181
656519001820	DctM-like transporters; Region: DctM; pfam06808
656519001821	C4-dicarboxylate anaerobic carrier; Region: DcuC; cl15356
656519001822	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
656519001823	putative substrate translocation pore; other site
656519001824	Major Facilitator Superfamily; Region: MFS_1; pfam07690
656519001825	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
656519001826	classical (c) SDRs; Region: SDR_c; cd05233
656519001827	NAD(P) binding site [chemical binding]; other site
656519001828	active site
656519001829	Sialidases or neuraminidases function to bind and hydrolyze terminal sialic acid residues from various glycoconjugates as well as playing roles in pathogenesis, bacterial nutrition and cellular interactions. They have a six-bladed, beta-propeller fold...; Region: Sialidase; cl01922
656519001830	BNR repeat-like domain; Region: BNR_2; pfam13088
656519001831	Helix-turn-helix domains; Region: HTH; cl00088
656519001832	HTH-like domain; Region: HTH_21; pfam13276
656519001833	Integrase core domain; Region: rve; cl01316
656519001834	Integrase core domain; Region: rve_3; cl15866
656519001835	This family is most closely related to the GT1 family of glycosyltransferases. cap1E in Streptococcus pneumoniae is required for the synthesis of type 1 capsular polysaccharides; Region: GT1_cap1E_like; cd03808
656519001836	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
656519001837	putative ADP-binding pocket [chemical binding]; other site
656519001838	Bacterial sugar transferase; Region: Bac_transf; cl00939
656519001839	aminotransferase, LLPSF_NHT_00031 family; Region: NHT_00031; TIGR04181
656519001840	3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616
656519001841	inhibitor-cofactor binding pocket; inhibition site
656519001842	pyridoxal 5'-phosphate binding site [chemical binding]; other site
656519001843	catalytic residue [active]
656519001844	Helix-turn-helix domains; Region: HTH; cl00088
656519001845	putative transposase OrfB; Reviewed; Region: PHA02517
656519001846	HTH-like domain; Region: HTH_21; pfam13276
656519001847	Integrase core domain; Region: rve; cl01316
656519001848	Integrase core domain; Region: rve_3; cl15866
656519001849	This family is most closely related to the GT1 family of glycosyltransferases. cap1E in Streptococcus pneumoniae is required for the synthesis of type 1 capsular polysaccharides; Region: GT1_cap1E_like; cd03808
656519001850	putative ADP-binding pocket [chemical binding]; other site
656519001851	Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826
656519001852	Helix-turn-helix domains; Region: HTH; cl00088
656519001853	Integrase core domain; Region: rve; cl01316
656519001854	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
656519001855	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
656519001856	NAD(P) binding site [chemical binding]; other site
656519001857	active site
656519001858	Mannose-1-phosphate guanylyltransferase [Cell envelope biogenesis, outer membrane]; Region: {ManC}; COG0836
656519001859	GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509
656519001860	Substrate binding site; other site
656519001861	Cupin domain; Region: Cupin_2; cl09118
656519001862	HD superfamily phosphohydrolases [General function prediction only]; Region: COG1078
656519001863	DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061
656519001864	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
656519001865	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
656519001866	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
656519001867	Helix-turn-helix domains; Region: HTH; cl00088
656519001868	Macro domain, Poa1p_like family. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ADP-ribose...; Region: Macro_Poa1p_like; cd02901
656519001869	ADP-ribose binding site [chemical binding]; other site
656519001870	Helix-hairpin-helix motif; Region: HHH_3; pfam12836
656519001871	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
656519001872	non-specific DNA binding site [nucleotide binding]; other site
656519001873	salt bridge; other site
656519001874	sequence-specific DNA binding site [nucleotide binding]; other site
656519001875	Domain of unknown function (DUF955); Region: DUF955; cl01076
656519001876	HIRAN domain; Region: HIRAN; cl07418
656519001877	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761
656519001878	Antidote-toxin recognition MazE; Region: Antitoxin-MazE; cl00877
656519001879	Helix-turn-helix domains; Region: HTH; cl00088
656519001880	HTH-like domain; Region: HTH_21; pfam13276
656519001881	Integrase core domain; Region: rve; cl01316
656519001882	Integrase core domain; Region: rve_3; cl15866
656519001883	Predicted nucleoside-diphosphate sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG1086
656519001884	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
656519001885	UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237
656519001886	NAD(P) binding site [chemical binding]; other site
656519001887	homodimer interface [polypeptide binding]; other site
656519001888	substrate binding site [chemical binding]; other site
656519001889	active site
656519001890	Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695
656519001891	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584
656519001892	transposase; Provisional; Region: PRK06526
656519001893	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
656519001894	Walker A motif; other site
656519001895	ATP binding site [chemical binding]; other site
656519001896	Walker B motif; other site
656519001897	Transposase IS200 like; Region: Y1_Tnp; cl00848
656519001898	Helix-turn-helix domains; Region: HTH; cl00088
656519001899	fibrous body protein; Provisional; Region: P10; PHA03386
656519001900	putative transposase OrfB; Reviewed; Region: PHA02517
656519001901	HTH-like domain; Region: HTH_21; pfam13276
656519001902	Integrase core domain; Region: rve; cl01316
656519001903	Integrase core domain; Region: rve_3; cl15866
656519001904	Helix-turn-helix domains; Region: HTH; cl00088
656519001905	Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279
656519001906	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
656519001907	active site
656519001908	phosphorylation site [posttranslational modification]
656519001909	intermolecular recognition site; other site
656519001910	dimerization interface [polypeptide binding]; other site
656519001911	LytTr DNA-binding domain; Region: LytTR; cl04498
656519001912	Putative regulator of cell autolysis [Signal transduction mechanisms]; Region: LytS; COG3275
656519001913	ECF-type riboflavin transporter, S component; Region: ECF-ribofla_trS; cl01942
656519001914	Histidine kinase; Region: His_kinase; pfam06580
656519001915	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
656519001916	ATP binding site [chemical binding]; other site
656519001917	Mg2+ binding site [ion binding]; other site
656519001918	G-X-G motif; other site
656519001919	TIM-barrel signal transduction protein; Region: TIM-br_sig_trns; cl15424
656519001920	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
656519001921	Probable transposase; Region: OrfB_IS605; pfam01385
656519001922	transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766
656519001923	Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282
656519001924	TIM-barrel signal transduction protein; Region: TIM-br_sig_trns; cl15424
656519001925	psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974
656519001926	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
656519001927	Walker A motif; other site
656519001928	ATP binding site [chemical binding]; other site
656519001929	Walker B motif; other site
656519001930	arginine finger; other site
656519001931	Helix-turn-helix domains; Region: HTH; cl00088
656519001932	Uncharacterized protein family (UPF0261); Region: UPF0261; cl02262
656519001933	TIM-barrel signal transduction protein; Region: TIM-br_sig_trns; cl15424
656519001934	Permease SLC13 (solute carrier 13).  The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115
656519001935	transmembrane helices; other site
656519001936	Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471
656519001937	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
656519001938	ABC transporter transmembrane region; Region: ABC_membrane; cl00549
656519001939	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
656519001940	Walker A/P-loop; other site
656519001941	ATP binding site [chemical binding]; other site
656519001942	Q-loop/lid; other site
656519001943	ABC transporter signature motif; other site
656519001944	Walker B; other site
656519001945	D-loop; other site
656519001946	H-loop/switch region; other site
656519001947	This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809
656519001948	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
656519001949	G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538
656519001950	glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207
656519001951	substrate binding site; other site
656519001952	tetramer interface; other site
656519001953	UDP-glucuronate decarboxylase (UGD) and related proteins, extended (e) SDRs; Region: UGD_SDR_e; cd05230
656519001954	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
656519001955	NAD binding site [chemical binding]; other site
656519001956	putative substrate binding site 2 [chemical binding]; other site
656519001957	putative substrate binding site 1 [chemical binding]; other site
656519001958	active site
656519001959	Domain of unknown function (DUF4422); Region: DUF4422; pfam14393
656519001960	Cupin domain; Region: Cupin_2; cl09118
656519001961	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
656519001962	active site
656519001963	dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254
656519001964	RmlD substrate binding domain; Region: RmlD_sub_bind; pfam04321
656519001965	NADP binding site [chemical binding]; other site
656519001966	active site
656519001967	putative substrate binding site [chemical binding]; other site
656519001968	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
656519001969	Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_d; cd04196
656519001970	Probable Catalytic site; other site
656519001971	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
656519001972	Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186
656519001973	Probable Catalytic site; other site
656519001974	metal-binding site
656519001975	dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088
656519001976	dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246
656519001977	NAD binding site [chemical binding]; other site
656519001978	substrate binding site [chemical binding]; other site
656519001979	homodimer interface [polypeptide binding]; other site
656519001980	active site
656519001981	O-Antigen ligase; Region: Wzy_C; cl04850
656519001982	CESA_like_1 is a member of the cellulose synthase (CESA) superfamily; Region: CESA_like_1; cd06439
656519001983	DXD motif; other site
656519001984	Bacterial sugar transferase; Region: Bac_transf; cl00939
656519001985	Protein of unknown function (DUF2905); Region: DUF2905; pfam11146
656519001986	Uncharacterized ACR, COG1993; Region: DUF190; cl00872
656519001987	NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025
656519001988	Methyltransferase domain; Region: Methyltransf_31; pfam13847
656519001989	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
656519001990	S-adenosylmethionine binding site [chemical binding]; other site
656519001991	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
656519001992	putative DNA binding site [nucleotide binding]; other site
656519001993	putative Zn2+ binding site [ion binding]; other site
656519001994	Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552
656519001995	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain [Transcription / Signal transduction mechanisms]; Region: PspF; COG1221
656519001996	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
656519001997	Walker A motif; other site
656519001998	ATP binding site [chemical binding]; other site
656519001999	Walker B motif; other site
656519002000	arginine finger; other site
656519002001	PRD domain; Region: PRD; cl15445
656519002002	PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006
656519002003	active pocket/dimerization site; other site
656519002004	active site
656519002005	phosphorylation site [posttranslational modification]
656519002006	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
656519002007	active site
656519002008	phosphorylation site [posttranslational modification]
656519002009	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
656519002010	active site
656519002011	phosphorylation site [posttranslational modification]
656519002012	PTS_IIB_galactitol: subunit IIB of enzyme II (EII) of the galactitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS).  In this system, EII is a galactitol-specific permease with two cytoplasmic domains (IIA and IIB) and a...; Region: PTS_IIB_galactitol; cd05566
656519002013	P-loop; other site
656519002014	active site
656519002015	phosphorylation site [posttranslational modification]
656519002016	PTS system sugar-specific permease component; Region: EIIC-GAT; cl04451
656519002017	Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cl00214
656519002018	intersubunit interface [polypeptide binding]; other site
656519002019	active site
656519002020	Zn2+ binding site [ion binding]; other site
656519002021	Mannose-1-phosphate guanylyltransferase [Cell envelope biogenesis, outer membrane]; Region: {ManC}; COG0836
656519002022	GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509
656519002023	Substrate binding site; other site
656519002024	Cupin domain; Region: Cupin_2; cl09118
656519002025	Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390
656519002026	Helix-turn-helix domains; Region: HTH; cl00088
656519002027	Putative sugar-binding domain; Region: Sugar-bind; pfam04198
656519002028	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
656519002029	Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407
656519002030	ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129
656519002031	This family represents the domain I of the carbohydrate uptake proteins that transport only monosaccharides (Monos).  The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and hexoses...; Region: ABC_Carb_Monos_I; cd03216
656519002032	Walker A/P-loop; other site
656519002033	ATP binding site [chemical binding]; other site
656519002034	Q-loop/lid; other site
656519002035	ABC transporter signature motif; other site
656519002036	Walker B; other site
656519002037	D-loop; other site
656519002038	H-loop/switch region; other site
656519002039	This family represents domain II of the carbohydrate uptake proteins that transport only monosaccharides (Monos).  The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and hexoses; Region: ABC_Carb_Monos_II; cd03215
656519002040	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
656519002041	TM-ABC transporter signature motif; other site
656519002042	tryptophan synthase subunit alpha; Provisional; Region: trpA; PRK13111
656519002043	Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724
656519002044	substrate binding site [chemical binding]; other site
656519002045	active site
656519002046	catalytic residues [active]
656519002047	heterodimer interface [polypeptide binding]; other site
656519002048	Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070
656519002049	uncharacterized xylulose kinase-like proteins, subgroup 2; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_XK_like_2; cd07805
656519002050	N- and C-terminal domain interface [polypeptide binding]; other site
656519002051	active site
656519002052	catalytic site [active]
656519002053	metal binding site [ion binding]; metal-binding site
656519002054	xylulose binding site [chemical binding]; other site
656519002055	ATP binding site [chemical binding]; other site
656519002056	putative homodimer interface [polypeptide binding]; other site
656519002057	Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer,  utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514
656519002058	FMN binding site [chemical binding]; other site
656519002059	dimer interface [polypeptide binding]; other site
656519002060	Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer,  utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514
656519002061	dimer interface [polypeptide binding]; other site
656519002062	Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239
656519002063	MgtE intracellular N domain; Region: MgtE_N; cl15244
656519002064	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE.  MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606
656519002065	Divalent cation transporter; Region: MgtE; cl00786
656519002066	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
656519002067	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
656519002068	active site
656519002069	catalytic tetrad [active]
656519002070	CoA-disulfide reductase; Region: CoA_CoA_reduc; TIGR03385
656519002071	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
656519002072	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
656519002073	Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349
656519002074	Helix-turn-helix domains; Region: HTH; cl00088
656519002075	SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339
656519002076	Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454
656519002077	Lactadehyde:propanediol oxidoreductase (LPO) catalyzes the interconversion between L-lactaldehyde and L-1,2-propanediol in Escherichia coli and other enterobacteria; Region: LPO; cd08176
656519002078	dimer interface [polypeptide binding]; other site
656519002079	active site
656519002080	metal binding site [ion binding]; metal-binding site
656519002081	Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518
656519002082	Ribose/Galactose Isomerase; Region: LacAB_rpiB; cl00485
656519002083	Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956
656519002084	active site
656519002085	intersubunit interactions; other site
656519002086	catalytic residue [active]
656519002087	transketolase; Reviewed; Region: PRK05899
656519002088	Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012
656519002089	TPP-binding site [chemical binding]; other site
656519002090	dimer interface [polypeptide binding]; other site
656519002091	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
656519002092	PYR/PP interface [polypeptide binding]; other site
656519002093	dimer interface [polypeptide binding]; other site
656519002094	TPP binding site [chemical binding]; other site
656519002095	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
656519002096	Glycerol-3-phosphate responsive antiterminator; Region: G3P_antiterm; cl00852
656519002097	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557
656519002098	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
656519002099	NAD(P) binding site [chemical binding]; other site
656519002100	active site
656519002101	Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070
656519002102	uncharacterized xylulose kinase-like proteins, subgroup 1; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_XK_like_1; cd07804
656519002103	N- and C-terminal domain interface [polypeptide binding]; other site
656519002104	putative active site [active]
656519002105	catalytic site [active]
656519002106	metal binding site [ion binding]; metal-binding site
656519002107	putative xylulose binding site [chemical binding]; other site
656519002108	putative ATP binding site [chemical binding]; other site
656519002109	putative homodimer interface [polypeptide binding]; other site
656519002110	Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947
656519002111	hypothetical protein; Provisional; Region: PRK08185
656519002112	intersubunit interface [polypeptide binding]; other site
656519002113	active site
656519002114	zinc binding site [ion binding]; other site
656519002115	Na+ binding site [ion binding]; other site
656519002116	L-sorbose-1-phosphate reductase; Region: sorbose_phosphate_red; cd08238
656519002117	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
656519002118	putative NAD(P) binding site [chemical binding]; other site
656519002119	catalytic Zn binding site [ion binding]; other site
656519002120	Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349
656519002121	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
656519002122	DNA-binding site [nucleotide binding]; DNA binding site
656519002123	SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339
656519002124	Glycerol-1-phosphate dehydrogenase (G1PDH) catalyzes the reversible reduction of dihydroxyacetone phosphate (DHAP) to glycerol-1-phosphate (G1P) in an NADH-dependent manner; Region: G1PDH; cd08175
656519002125	active site
656519002126	metal binding site [ion binding]; metal-binding site
656519002127	Predicted sugar phosphatases of the HAD superfamily [Carbohydrate transport and metabolism]; Region: NagD; COG0647
656519002128	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
656519002129	active site
656519002130	motif I; other site
656519002131	motif II; other site
656519002132	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
656519002133	dihydroxyacetone kinase subunit DhaK; Provisional; Region: PRK14481; cl10557
656519002134	Dihydroxyacetone kinase [Carbohydrate transport and metabolism]; Region: DAK1; COG2376
656519002135	Sulfatase; Region: Sulfatase; cl10460
656519002136	Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584
656519002137	Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615
656519002138	active site
656519002139	catalytic site [active]
656519002140	Uncharacterized oxidoreductases, Fe-dependent alcohol dehydrogenase family [Energy production and conversion]; Region: COG1979
656519002141	Butanol dehydrogenase catalyzes the conversion of butyraldehyde to butanol with the cofactor NAD(P)H being oxidized in the process; Region: BDH; cd08187
656519002142	dimer interface [polypeptide binding]; other site
656519002143	active site
656519002144	metal binding site [ion binding]; metal-binding site
656519002145	Na+/H+ ion antiporter subunit; Region: MNHE; cl00807
656519002146	Multiple resistance and pH regulation protein F (MrpF / PhaF); Region: MrpF_PhaF; cl09154
656519002147	Na+/H+ antiporter subunit; Region: PhaG_MnhG_YufB; cl00583
656519002148	Domain of unknown function (DUF4040); Region: DUF4040; cl00676
656519002149	Domain of unknown function (DUF4040); Region: DUF4040; cl00676
656519002150	NADH-ubiquinone/plastoquinone oxidoreductase chain 4L; Region: Oxidored_q2; cl00492
656519002151	putative monovalent cation/H+ antiporter subunit D; Reviewed; Region: PRK12667
656519002152	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; cl14187
656519002153	NADH dehydrogenase subunit 2; Provisional; Region: ND2; MTH00144
656519002154	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; cl14187
656519002155	Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473
656519002156	M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886
656519002157	metal binding site [ion binding]; metal-binding site
656519002158	dimer interface [polypeptide binding]; other site
656519002159	Aspartate/tyrosine/aromatic aminotransferase [Amino acid transport and metabolism]; Region: COG0436
656519002160	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
656519002161	pyridoxal 5'-phosphate binding site [chemical binding]; other site
656519002162	homodimer interface [polypeptide binding]; other site
656519002163	catalytic residue [active]
656519002164	Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cl00140
656519002165	Catalytic site; other site
656519002166	ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917
656519002167	C4-dicarboxylate anaerobic carrier; Region: DcuC; cl15356
656519002168	Domain of unknown function (DUF1850); Region: DUF1850; cl01950
656519002169	NMT1-like family; Region: NMT1_2; cl15260
656519002170	TRAP-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: Imp; COG2358
656519002171	Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659
656519002172	Sulfate transporter family; Region: Sulfate_transp; cl15842
656519002173	putative iron-only hydrogenase system regulator; Region: hyd_TM1266; TIGR03959
656519002174	thiamine biosynthesis protein ThiH; Reviewed; Region: thiH; PRK09613
656519002175	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
656519002176	FeS/SAM binding site; other site
656519002177	Biotin and Thiamin Synthesis associated domain; Region: BATS; cl06149
656519002178	biotin synthase; Provisional; Region: PRK07094
656519002179	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
656519002180	FeS/SAM binding site; other site
656519002181	Biotin and Thiamin Synthesis associated domain; Region: BATS; cl06149
656519002182	Sulfate transporter family; Region: Sulfate_transp; cl15842
656519002183	Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659
656519002184	Sulfate transporter family; Region: Sulfate_transp; cl15842
656519002185	Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042
656519002186	Permease SLC13 (solute carrier 13).  The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115
656519002187	transmembrane helices; other site
656519002188	Anion permease ArsB/NhaD.  These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life.  A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl15357
656519002189	Anion permease ArsB/NhaD.  These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life.  A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl15357
656519002190	Permease SLC13 (solute carrier 13).  The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115
656519002191	Protein of unknown function (DUF2089); Region: DUF2089; pfam09862
656519002192	ECF-type riboflavin transporter, S component; Region: ECF-ribofla_trS; cl01942
656519002193	Thiamine-precursor transporter protein (ThiW); Region: ThiW; cl01952
656519002194	4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169
656519002195	dimer interface [polypeptide binding]; other site
656519002196	substrate binding site [chemical binding]; other site
656519002197	ATP binding site [chemical binding]; other site
656519002198	Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564
656519002199	thiamine phosphate binding site [chemical binding]; other site
656519002200	active site
656519002201	pyrophosphate binding site [ion binding]; other site
656519002202	4-methyl-5-beta-hydroxyethylthiazole (Thz) kinase catalyzes the phosphorylation of the hydroxylgroup of Thz. A reaction that allows cells to recycle Thz into the thiamine biosynthesis pathway, as an alternative to its synthesis from cysteine, tyrosine...; Region: THZ_kinase; cd01170
656519002203	substrate binding site [chemical binding]; other site
656519002204	multimerization interface [polypeptide binding]; other site
656519002205	ATP binding site [chemical binding]; other site
656519002206	SAM-dependent methyltransferases [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: SmtA; COG0500
656519002207	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
656519002208	S-adenosylmethionine binding site [chemical binding]; other site
656519002209	Heme oxygenase catalyzes the rate limiting step in the degradation of heme to bilirubin, it is essential for recycling of iron from heme. Heme is used as a substrate and cofactor for its own degradation to biliverdin, iron, and carbon monoxide. This...; Region: HemeO; cl15243
656519002210	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
656519002211	putative heme d1 biosynthesis radical SAM protein NirJ1; Region: rSAM_NirJ1; TIGR04054
656519002212	FeS/SAM binding site; other site
656519002213	Domain of unknown function (DUF4008); Region: DUF4008; cl14869
656519002214	Transposase domain (DUF772); Region: DUF772; cl15789
656519002215	Transposase domain (DUF772); Region: DUF772; cl15789
656519002216	Transcriptional regulator containing PAS, AAA-type ATPase, and DNA-binding domains [Transcription / Signal transduction mechanisms]; Region: RocR; COG3829
656519002217	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
656519002218	Walker A motif; other site
656519002219	ATP binding site [chemical binding]; other site
656519002220	Walker B motif; other site
656519002221	arginine finger; other site
656519002222	Helix-turn-helix domains; Region: HTH; cl00088
656519002223	Aldehyde ferredoxin oxidoreductase, N-terminal domain; Region: AFOR_N; cl08354
656519002224	pyruvate formate-lyase; Region: PFL2-3; TIGR01774
656519002225	Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939
656519002226	Domain of unknown function (DUF336); Region: DUF336; cl01249
656519002227	glycyl-radical enzyme activating protein family; Region: PFLE_PFLC; TIGR02494
656519002228	4Fe-4S binding domain; Region: Fer4; cl02805
656519002229	Aldehyde ferredoxin oxidoreductase, N-terminal domain; Region: AFOR_N; cl08354
656519002230	Aldehyde:ferredoxin oxidoreductase [Energy production and conversion]; Region: COG2414
656519002231	Aldehyde ferredoxin oxidoreductase, domains 2 & 3; Region: AFOR_C; pfam01314
656519002232	Ubiquitin-like proteins; Region: UBQ; cl00155
656519002233	charged pocket; other site
656519002234	hydrophobic patch; other site
656519002235	hypothetical protein; Provisional; Region: PRK08328
656519002236	ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757
656519002237	ATP binding site [chemical binding]; other site
656519002238	substrate interface [chemical binding]; other site
656519002239	Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446
656519002240	Family of unknown function (DUF1028); Region: DUF1028; pfam06267
656519002241	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
656519002242	Fructokinases (FRKs) mainly from bacteria and plants are enzymes with high specificity for fructose, as are all FRKs, but they catalyzes the conversion of fructose to fructose-6-phosphate, which is an entry point into glycolysis via conversion into...; Region: bac_FRK; cd01167
656519002243	putative substrate binding site [chemical binding]; other site
656519002244	putative ATP binding site [chemical binding]; other site
656519002245	Argininosuccinate synthase [Amino acid transport and metabolism]; Region: ArgG; COG0137
656519002246	Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate .  In...; Region: Argininosuccinate_Synthase; cd01999
656519002247	ANP binding site [chemical binding]; other site
656519002248	Substrate Binding Site II [chemical binding]; other site
656519002249	Substrate Binding Site I [chemical binding]; other site
656519002250	argininosuccinate lyase; Provisional; Region: PRK00855
656519002251	Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359
656519002252	active sites [active]
656519002253	tetramer interface [polypeptide binding]; other site
656519002254	Peptidase family M48; Region: Peptidase_M48; cl12018
656519002255	CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cd00400
656519002256	Voltage gated chloride channel; Region: Voltage_CLC; pfam00654
656519002257	Cl- selectivity filter; other site
656519002258	Cl- binding residues [ion binding]; other site
656519002259	pore gating glutamate residue; other site
656519002260	dimer interface [polypeptide binding]; other site
656519002261	K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569
656519002262	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
656519002263	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
656519002264	dimerization interface [polypeptide binding]; other site
656519002265	putative DNA binding site [nucleotide binding]; other site
656519002266	putative Zn2+ binding site [ion binding]; other site
656519002267	Transposase IS200 like; Region: Y1_Tnp; cl00848
656519002268	Transposase, Mutator family; Region: Transposase_mut; pfam00872
656519002269	MULE transposase domain; Region: MULE; pfam10551
656519002270	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
656519002271	ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192
656519002272	substrate binding site [chemical binding]; other site
656519002273	ATP binding site [chemical binding]; other site
656519002274	Phosphomannose isomerase [Carbohydrate transport and metabolism]; Region: ManA; COG1482
656519002275	Phosphomannose isomerase type I; Region: PMI_typeI; cl15429
656519002276	Transcriptional regulator [Transcription]; Region: IclR; COG1414
656519002277	Helix-turn-helix domains; Region: HTH; cl00088
656519002278	Bacterial transcriptional regulator; Region: IclR; pfam01614
656519002279	CoA enzyme activase uncharacterized domain (DUF2229); Region: DUF2229; pfam09989
656519002280	2-hydroxyglutaryl-CoA dehydratase, D-component; Region: HGD-D; pfam06050
656519002281	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3581
656519002282	CoA enzyme activase uncharacterized domain (DUF2229); Region: DUF2229; pfam09989
656519002283	FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121
656519002284	fumarate hydratase; Reviewed; Region: fumC; PRK00485
656519002285	Class II fumarases; Region: Fumarase_classII; cd01362
656519002286	active site
656519002287	tetramer interface [polypeptide binding]; other site
656519002288	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
656519002289	Zn2+ binding site [ion binding]; other site
656519002290	Mg2+ binding site [ion binding]; other site
656519002291	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
656519002292	Helix-turn-helix domains; Region: HTH; cl00088
656519002293	Cupin domain; Region: Cupin_2; cl09118
656519002294	Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538
656519002295	Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538
656519002296	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
656519002297	Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404
656519002298	Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404
656519002299	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
656519002300	Protein export membrane protein; Region: SecD_SecF; cl14618
656519002301	Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; cl08040
656519002302	Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019
656519002303	N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436
656519002304	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
656519002305	Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; cl15856
656519002306	AAK_NAGK-C: N-Acetyl-L-glutamate kinase - cyclic (NAGK-C) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine biosynthesis found in some bacteria and photosynthetic organisms using the...; Region: AAK_NAGK-C; cd04250
656519002307	feedback inhibition sensing region; other site
656519002308	homohexameric interface [polypeptide binding]; other site
656519002309	nucleotide binding site [chemical binding]; other site
656519002310	N-acetyl-L-glutamate binding site [chemical binding]; other site
656519002311	acetylornithine aminotransferase; Provisional; Region: PRK02627
656519002312	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
656519002313	inhibitor-cofactor binding pocket; inhibition site
656519002314	pyridoxal 5'-phosphate binding site [chemical binding]; other site
656519002315	catalytic residue [active]
656519002316	hypothetical protein; Provisional; Region: PRK05590
656519002317	SEC-C motif; Region: SEC-C; pfam02810
656519002318	Predicted membrane protein [Function unknown]; Region: COG4684
656519002319	Protein of unknown function (DUF3816); Region: DUF3816; pfam12822
656519002320	Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419
656519002321	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
656519002322	motif II; other site
656519002323	Mechanosensitive ion channel; Region: MS_channel; pfam00924
656519002324	DJ-1 family protein; Region: not_thiJ; TIGR01383
656519002325	Type 1 glutamine amidotransferase (GATase1)-like domain found in Human DJ-1; Region: GATase1_DJ-1; cd03135
656519002326	conserved cys residue [active]
656519002327	alpha-glucan phosphorylases; Region: more_P_ylases; TIGR02094
656519002328	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
656519002329	This family is most closely related to the GT1 family of glycosyltransferases. The sucrose-phosphate synthases in this family may be unique to plants and photosynthetic bacteria. This enzyme catalyzes the synthesis of sucrose 6-phosphate from fructose...; Region: GT1_Sucrose_synthase; cd03800
656519002330	sucrose-phosphate synthase, putative, glycosyltransferase domain; Region: sucr_P_syn_N; TIGR02472
656519002331	putative ADP-binding pocket [chemical binding]; other site
656519002332	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
656519002333	2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166
656519002334	substrate binding site [chemical binding]; other site
656519002335	ATP binding site [chemical binding]; other site
656519002336	pullulanase, type I; Region: pulA_typeI; TIGR02104
656519002337	Early set domain associated with the catalytic domain of pullulanase (also called dextrinase and alpha-dextrin endo-1,6-alpha glucosidase); Region: E_set_Pullulanase; cd02860
656519002338	Alpha amylase catalytic domain found in Pullulanase (also called dextrinase; alpha-dextrin endo-1,6-alpha glucosidase), limit dextrinase, and related proteins; Region: AmyAc_Pullulanase_LD-like; cd11341
656519002339	Ca binding site [ion binding]; other site
656519002340	active site
656519002341	catalytic site [active]
656519002342	Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115
656519002343	Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548
656519002344	glucose-1-phosphate adenylyltransferase, GlgD subunit; Region: glgD; TIGR02092
656519002345	ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508
656519002346	ligand binding site; other site
656519002347	oligomer interface; other site
656519002348	Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651
656519002349	dimer interface [polypeptide binding]; other site
656519002350	N-terminal domain interface [polypeptide binding]; other site
656519002351	sulfate 1 binding site; other site
656519002352	glycogen branching enzyme; Provisional; Region: PRK12313
656519002353	N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855
656519002354	Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322
656519002355	active site
656519002356	catalytic site [active]
656519002357	Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; cl02706
656519002358	glycogen synthase; Provisional; Region: glgA; PRK00654
656519002359	This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791
656519002360	ADP-binding pocket [chemical binding]; other site
656519002361	homodimer interface [polypeptide binding]; other site
656519002362	Helix-hairpin-helix motif; Region: HHH_3; pfam12836
656519002363	L-fucose isomerase (FucIase) and L-arabinose isomerase (AI) family; composed of FucIase, AI and similar proteins. FucIase converts L-fucose, an aldohexose, to its ketose form, which prepares it for aldol cleavage (similar to the isomerization of glucose...; Region: L-fuc_L-ara-isomerases; cl00947
656519002364	substrate binding site [chemical binding]; other site
656519002365	trimer interface [polypeptide binding]; other site
656519002366	hexamer (dimer of trimers) interface [polypeptide binding]; other site
656519002367	Mn binding site [ion binding]; other site
656519002368	Cysteine desulfurase activator ATPase [Posttranslational modification, protein turnover, chaperones]; Region: sufC; COG0396
656519002369	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
656519002370	Walker A/P-loop; other site
656519002371	ATP binding site [chemical binding]; other site
656519002372	Q-loop/lid; other site
656519002373	ABC transporter signature motif; other site
656519002374	Walker B; other site
656519002375	D-loop; other site
656519002376	H-loop/switch region; other site
656519002377	Uncharacterized protein family (UPF0051); Region: UPF0051; cl03223
656519002378	ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715
656519002379	NMT1-like family; Region: NMT1_2; cl15260
656519002380	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
656519002381	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427
656519002382	ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116
656519002383	NrtD and SsuB are the ATP-binding subunits of the bacterial ABC-type nitrate and sulfonate transport systems, respectively.  ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars; Region: ABC_NrtD_SsuB_transporters; cd03293
656519002384	Walker A/P-loop; other site
656519002385	ATP binding site [chemical binding]; other site
656519002386	Q-loop/lid; other site
656519002387	ABC transporter signature motif; other site
656519002388	Walker B; other site
656519002389	D-loop; other site
656519002390	H-loop/switch region; other site
656519002391	Uncharacterized conserved protein (DUF2156); Region: DUF2156; cl12090
656519002392	dihydrolipoamide dehydrogenase; Region: lipoamide_DH; TIGR01350
656519002393	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
656519002394	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
656519002395	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
656519002396	Uncharacterized conserved protein [Function unknown]; Region: COG3461
656519002397	Uncharacterized protein, linocin/CFP29 homolog [Function unknown]; Region: COG1659
656519002398	Encapsulating protein for peroxidase; Region: Linocin_M18; cl12047
656519002399	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
656519002400	FeS/SAM binding site; other site
656519002401	Radical SAM superfamily; Region: Radical_SAM; pfam04055
656519002402	Glycine cleavage system protein P (pyridoxal-binding), N-terminal domain [Amino acid transport and metabolism]; Region: GcvP; COG0403
656519002403	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
656519002404	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
656519002405	catalytic residue [active]
656519002406	Glycine cleavage system protein P (pyridoxal-binding), C-terminal domain [Amino acid transport and metabolism]; Region: GcvP; COG1003
656519002407	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
656519002408	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
656519002409	catalytic residue [active]
656519002410	Diacylglycerol kinase catalytic domain; Region: DAGK_cat; cl01255
656519002411	putative DNA modification/repair radical SAM protein; Region: rSAM_link_UDG; TIGR03916
656519002412	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cl15377
656519002413	FeS/SAM binding site; other site
656519002414	Domain of unknown function (DUF4130; Region: DUF4130; cl14836
656519002415	UDP-N-acetylglucosamine 2-epimerase; Region: wecB; TIGR00236
656519002416	Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase  family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786
656519002417	active site
656519002418	homodimer interface [polypeptide binding]; other site
656519002419	2-oxoacid:acceptor oxidoreductase, alpha subunit; Region: OAFO_sf; TIGR03710
656519002420	Pyruvate ferredoxin/flavodoxin oxidoreductase; Region: POR; cl00546
656519002421	Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034
656519002422	dimer interface [polypeptide binding]; other site
656519002423	PYR/PP interface [polypeptide binding]; other site
656519002424	TPP binding site [chemical binding]; other site
656519002425	substrate binding site [chemical binding]; other site
656519002426	2-oxoacid ferredoxin oxidoreductase subunit beta; Provisional; Region: PRK11869
656519002427	Thiamine pyrophosphate (TPP family), 2-oxoglutarate ferredoxin oxidoreductase (OGFOR) subfamily, TPP-binding module; OGFOR catalyzes the oxidative decarboxylation of 2-oxo-acids, with ferredoxin acting as an electron acceptor. In the TCA cycle, OGFOR...; Region: TPP_OGFOR; cd03375
656519002428	TPP-binding site [chemical binding]; other site
656519002429	Pyruvate ferredoxin oxidoreductase beta subunit C terminal; Region: PFO_beta_C; pfam12367
656519002430	Uncharacterized family of ferritin-like proteins found in archaea and bacteria; Region: Ferritin_like_AB; cd01045
656519002431	diiron binding motif [ion binding]; other site
656519002432	hybrid cluster protein; Provisional; Region: PRK05290
656519002433	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
656519002434	ACS interaction site; other site
656519002435	CODH interaction site; other site
656519002436	Hybrid cluster protein (HCP), formerly known as prismane, is thought to play a role in nitrogen metabolism but its specific function is unknown. HCP has three structural domains, an N-terminal alpha-helical domain, and two similar domains comprising a...; Region: HCP; cd01914
656519002437	hybrid metal cluster; other site
656519002438	Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cd00306
656519002439	active site
656519002440	catalytic residues [active]
656519002441	[FeFe] hydrogenase H-cluster maturation GTPase HydF; Region: GTP_HydF; TIGR03918
656519002442	E. coli Ras-like protein (Era)-like GTPase; Region: Era_like; cd00880
656519002443	G1 box; other site
656519002444	GTP/Mg2+ binding site [chemical binding]; other site
656519002445	Switch I region; other site
656519002446	G2 box; other site
656519002447	Switch II region; other site
656519002448	G3 box; other site
656519002449	G4 box; other site
656519002450	G5 box; other site
656519002451	phosphonate ABC transporter, ATP-binding protein; Region: ABC_phnC; TIGR02315
656519002452	ABC-type phosphate/phosphonate transport system. Phosphonates are a class of organophosphorus compounds characterized by a chemically stable carbon-to-phosphorus (C-P) bond.  Phosphonates are widespread among naturally occurring compounds in all...; Region: ABC_PhnC_transporter; cd03256
656519002453	Walker A/P-loop; other site
656519002454	ATP binding site [chemical binding]; other site
656519002455	Q-loop/lid; other site
656519002456	ABC transporter signature motif; other site
656519002457	Walker B; other site
656519002458	D-loop; other site
656519002459	H-loop/switch region; other site
656519002460	phosphonate ABC transporter, permease protein PhnE; Region: PhnE; TIGR01097
656519002461	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
656519002462	dimer interface [polypeptide binding]; other site
656519002463	conserved gate region; other site
656519002464	ABC-ATPase subunit interface; other site
656519002465	phosphonate ABC transporter, permease protein PhnE; Region: PhnE; TIGR01097
656519002466	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
656519002467	dimer interface [polypeptide binding]; other site
656519002468	conserved gate region; other site
656519002469	ABC-ATPase subunit interface; other site
656519002470	NMT1-like family; Region: NMT1_2; cl15260
656519002471	aspartate ammonia-lyase; Provisional; Region: aspA; PRK12273
656519002472	Aspartase; Region: Aspartase; cd01357
656519002473	active sites [active]
656519002474	tetramer interface [polypeptide binding]; other site
656519002475	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
656519002476	Probable transposase; Region: OrfB_IS605; pfam01385
656519002477	transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766
656519002478	Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282
656519002479	Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446
656519002480	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
656519002481	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
656519002482	active site residue [active]
656519002483	NQR2, RnfD, RnfE family; Region: NQR2_RnfD_RnfE; cl00779
656519002484	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
656519002485	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
656519002486	ligand binding site [chemical binding]; other site
656519002487	flexible hinge region; other site
656519002488	Helix-turn-helix domains; Region: HTH; cl00088
656519002489	Domain of unknown function (DUF1858); Region: DUF1858; cl14817
656519002490	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
656519002491	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
656519002492	cobalt transport protein ATP-binding subunit; Region: cbiO; TIGR01166
656519002493	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
656519002494	Walker A/P-loop; other site
656519002495	ATP binding site [chemical binding]; other site
656519002496	Q-loop/lid; other site
656519002497	ABC transporter signature motif; other site
656519002498	Walker B; other site
656519002499	D-loop; other site
656519002500	H-loop/switch region; other site
656519002501	DAK2 domain; Region: Dak2; cl03685
656519002502	Uncharacterized protein, DegV family COG1307; Region: DegV; cl00577
656519002503	Phospholipid methyltransferase; Region: PEMT; cl00763
656519002504	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
656519002505	This family is most closely related to the GT1 family of glycosyltransferases. wlbH in Bordetella parapertussis has been shown to be required for the biosynthesis of a trisaccharide that, when attached to the B. pertussis lipopolysaccharide (LPS) core; Region: GT1_wlbH_like; cd03798
656519002506	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
656519002507	6-phosphogluconate dehydrogenase; Validated; Region: PRK09287
656519002508	6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393
656519002509	Putative cyclase; Region: Cyclase; cl00814
656519002510	glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722
656519002511	Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479
656519002512	Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781
656519002513	Uncharacterized ACR, YkgG family COG1556; Region: DUF162; cl00674
656519002514	Glutamine cyclotransferase [Posttranslational modification, protein turnover, chaperones]; Region: COG3823
656519002515	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
656519002516	Helix-turn-helix domains; Region: HTH; cl00088
656519002517	Predicted exporters of the RND superfamily [General function prediction only]; Region: COG1033
656519002518	Protein export membrane protein; Region: SecD_SecF; cl14618
656519002519	Predicted exporters of the RND superfamily [General function prediction only]; Region: COG1033
656519002520	Protein of unknown function (DUF1329); Region: DUF1329; pfam07044
656519002521	benzoyl-CoA oxygenase/reductase, BoxA protein; Region: benzo_boxA; TIGR03224
656519002522	4Fe-4S binding domain; Region: Fer4; cl02805
656519002523	serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011
656519002524	Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378
656519002525	dimer interface [polypeptide binding]; other site
656519002526	glycine-pyridoxal phosphate binding site [chemical binding]; other site
656519002527	active site
656519002528	folate binding site [chemical binding]; other site
656519002529	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
656519002530	haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282
656519002531	active site
656519002532	motif I; other site
656519002533	motif II; other site
656519002534	Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391
656519002535	ROK family protein (putative glucokinase); Region: ROK_glcA_fam; TIGR00744
656519002536	FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121
656519002537	HPr kinase/phosphorylase; Provisional; Region: PRK05428
656519002538	DRTGG domain; Region: DRTGG; cl12147
656519002539	HprK/P, the bifunctional histidine-containing protein kinase/phosphatase, controls the phosphorylation state of the phosphocarrier protein HPr and regulates the utilization of carbon sources by gram-positive bacteria. It catalyzes both the ATP-dependent...; Region: HprK_C; cd01918
656519002540	Hpr binding site; other site
656519002541	active site
656519002542	homohexamer subunit interaction site [polypeptide binding]; other site
656519002543	DOMON-like domain of various glycoside hydrolases; Region: DOMON_glucodextranase_like; cd09626
656519002544	putative ligand binding site [chemical binding]; other site
656519002545	Isoprenoid Biosynthesis enzymes, Class 1; Region: Isoprenoid_Biosyn_C1; cl00210
656519002546	substrate binding pocket [chemical binding]; other site
656519002547	substrate-Mg2+ binding site; other site
656519002548	aspartate-rich region 1; other site
656519002549	aspartate-rich region 2; other site
656519002550	P-loop ATPase protein family; Region: ATP_bind_2; cl15794
656519002551	Predicted P-loop-containing kinase [General function prediction only]; Region: COG1660
656519002552	family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187
656519002553	Uncharacterized protein family UPF0052; Region: UPF0052; pfam01933
656519002554	phosphate binding site [ion binding]; other site
656519002555	putative substrate binding pocket [chemical binding]; other site
656519002556	dimer interface [polypeptide binding]; other site
656519002557	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1481
656519002558	Sporulation Regulator WhiA N terminal; Region: WhiA_N; pfam10298
656519002559	Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390
656519002560	Putative sugar-binding domain; Region: Sugar-bind; pfam04198
656519002561	glyceraldehyde-3-phosphate dehydrogenase, type I; Region: GAPDH-I; TIGR01534
656519002562	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
656519002563	Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; cl15856
656519002564	Phosphoglycerate kinase; Region: PGK; pfam00162
656519002565	Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318
656519002566	substrate binding site [chemical binding]; other site
656519002567	hinge regions; other site
656519002568	ADP binding site [chemical binding]; other site
656519002569	catalytic site [active]
656519002570	Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311
656519002571	substrate binding site [chemical binding]; other site
656519002572	dimer interface [polypeptide binding]; other site
656519002573	catalytic triad [active]
656519002574	Sulfatase; Region: Sulfatase; cl10460
656519002575	Phosphoglyceromutase [Carbohydrate transport and metabolism]; Region: GpmI; COG0696
656519002576	enolase; Provisional; Region: eno; PRK00077
656519002577	Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313
656519002578	dimer interface [polypeptide binding]; other site
656519002579	metal binding site [ion binding]; metal-binding site
656519002580	substrate binding pocket [chemical binding]; other site
656519002581	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
656519002582	GAF domain; Region: GAF; cl15785
656519002583	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
656519002584	Zn2+ binding site [ion binding]; other site
656519002585	Mg2+ binding site [ion binding]; other site
656519002586	Helix-turn-helix domains; Region: HTH; cl00088
656519002587	Transposase, Mutator family; Region: Transposase_mut; pfam00872
656519002588	MULE transposase domain; Region: MULE; pfam10551
656519002589	Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538
656519002590	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
656519002591	Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404
656519002592	Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404
656519002593	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
656519002594	Preprotein translocase SecG subunit; Region: SecG; cl09123
656519002595	Inorganic pyrophosphatase [Energy production and conversion]; Region: OVP1; cl11452
656519002596	Inorganic H+ pyrophosphatase; Region: H_PPase; pfam03030
656519002597	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
656519002598	CoenzymeA binding site [chemical binding]; other site
656519002599	subunit interaction site [polypeptide binding]; other site
656519002600	PHB binding site; other site
656519002601	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076
656519002602	ribonuclease R; Region: RNase_R; TIGR02063
656519002603	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
656519002604	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
656519002605	RNB domain; Region: RNB; pfam00773
656519002606	S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase play an important...; Region: S1_RNase_R; cd04471
656519002607	RNA binding site [nucleotide binding]; other site
656519002608	Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294
656519002609	SmpB-tmRNA interface; other site
656519002610	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
656519002611	putative active site [active]
656519002612	heme pocket [chemical binding]; other site
656519002613	PAS domain; Region: PAS_9; pfam13426
656519002614	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
656519002615	putative active site [active]
656519002616	heme pocket [chemical binding]; other site
656519002617	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
656519002618	metal binding site [ion binding]; metal-binding site
656519002619	active site
656519002620	I-site; other site
656519002621	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
656519002622	Zn2+ binding site [ion binding]; other site
656519002623	Mg2+ binding site [ion binding]; other site
656519002624	Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668
656519002625	Mechanosensitive ion channel; Region: MS_channel; pfam00924
656519002626	Protein of unknown function (DUF503); Region: DUF503; cl00669
656519002627	Chromate transporter; Region: Chromate_transp; pfam02417
656519002628	Chromate transporter; Region: Chromate_transp; pfam02417
656519002629	ABC-2 type transporter; Region: ABC2_membrane; cl11417
656519002630	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
656519002631	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
656519002632	Walker A/P-loop; other site
656519002633	ATP binding site [chemical binding]; other site
656519002634	Q-loop/lid; other site
656519002635	ABC transporter signature motif; other site
656519002636	Walker B; other site
656519002637	D-loop; other site
656519002638	H-loop/switch region; other site
656519002639	PAS domain; Region: PAS_9; pfam13426
656519002640	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
656519002641	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
656519002642	putative active site [active]
656519002643	heme pocket [chemical binding]; other site
656519002644	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
656519002645	dimer interface [polypeptide binding]; other site
656519002646	phosphorylation site [posttranslational modification]
656519002647	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
656519002648	ATP binding site [chemical binding]; other site
656519002649	Mg2+ binding site [ion binding]; other site
656519002650	G-X-G motif; other site
656519002651	Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833
656519002652	AMIN domain; Region: AMIN; pfam11741
656519002653	AMIN domain; Region: AMIN; pfam11741
656519002654	N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696
656519002655	active site
656519002656	metal binding site [ion binding]; metal-binding site
656519002657	Sporulation and spore germination; Region: Germane; cl11253
656519002658	Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518
656519002659	ribonuclease PH; Reviewed; Region: rph; PRK00173
656519002660	Ribonuclease PH; Region: RNase_PH_bact; cd11362
656519002661	hexamer interface [polypeptide binding]; other site
656519002662	active site
656519002663	NTPase/HAM1.  This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515
656519002664	active site
656519002665	dimerization interface [polypeptide binding]; other site
656519002666	YibE/F-like protein; Region: YibE_F; cl02259
656519002667	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
656519002668	metal binding site [ion binding]; metal-binding site
656519002669	active site
656519002670	I-site; other site
656519002671	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
656519002672	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
656519002673	Helix-turn-helix domains; Region: HTH; cl00088
656519002674	trigger factor; Provisional; Region: tig; PRK01490
656519002675	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; cl11587
656519002676	Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698
656519002677	Clp protease; Region: CLP_protease; pfam00574
656519002678	Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017
656519002679	oligomer interface [polypeptide binding]; other site
656519002680	active site residues [active]
656519002681	ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342
656519002682	ClpX C4-type zinc finger; Region: zf-C4_ClpX; cl05964
656519002683	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
656519002684	Walker A motif; other site
656519002685	ATP binding site [chemical binding]; other site
656519002686	Walker B motif; other site
656519002687	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; cl11083
656519002688	ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466
656519002689	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
656519002690	Walker A motif; other site
656519002691	ATP binding site [chemical binding]; other site
656519002692	Walker B motif; other site
656519002693	arginine finger; other site
656519002694	Subunit ChlI of Mg-chelatase; Region: ChlI; cl12214
656519002695	Predicted GTPase [General function prediction only]; Region: COG0218
656519002696	YihA (EngB) GTPase family; Region: YihA_EngB; cd01876
656519002697	G1 box; other site
656519002698	GTP/Mg2+ binding site [chemical binding]; other site
656519002699	Switch I region; other site
656519002700	G2 box; other site
656519002701	G3 box; other site
656519002702	Switch II region; other site
656519002703	G4 box; other site
656519002704	G5 box; other site
656519002705	SAM-dependent methyltransferases [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: SmtA; COG0500
656519002706	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
656519002707	S-adenosylmethionine binding site [chemical binding]; other site
656519002708	NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252
656519002709	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
656519002710	ApbE family; Region: ApbE; cl00643
656519002711	Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685
656519002712	substrate binding pocket [chemical binding]; other site
656519002713	chain length determination region; other site
656519002714	substrate-Mg2+ binding site; other site
656519002715	catalytic residues [active]
656519002716	aspartate-rich region 1; other site
656519002717	active site lid residues [active]
656519002718	aspartate-rich region 2; other site
656519002719	peroxiredoxin; Provisional; Region: PRK13189
656519002720	Peroxiredoxin (PRX) family, 1-cys PRX subfamily; composed of PRXs containing only one conserved cysteine, which serves as the peroxidatic cysteine. They are homodimeric thiol-specific antioxidant (TSA) proteins that confer a protective role in cells by...; Region: PRX_1cys; cd03016
656519002721	dimer interface [polypeptide binding]; other site
656519002722	decamer (pentamer of dimers) interface [polypeptide binding]; other site
656519002723	catalytic triad [active]
656519002724	Putative peptidoglycan binding domain; Region: PG_binding_1; cl15437
656519002725	membrane-bound lytic murein transglycosylase D; Provisional; Region: mltD; PRK10783
656519002726	Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118
656519002727	putative peptidoglycan binding site; other site
656519002728	Histidine kinase; Region: His_kinase; pfam06580
656519002729	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
656519002730	ATP binding site [chemical binding]; other site
656519002731	Mg2+ binding site [ion binding]; other site
656519002732	G-X-G motif; other site
656519002733	Response regulator containing CheY-like receiver domain and AraC-type DNA-binding domain [Signal transduction mechanisms]; Region: COG4753
656519002734	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
656519002735	active site
656519002736	phosphorylation site [posttranslational modification]
656519002737	intermolecular recognition site; other site
656519002738	dimerization interface [polypeptide binding]; other site
656519002739	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
656519002740	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
656519002741	TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638
656519002742	Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441
656519002743	Tripartite ATP-independent periplasmic transporters, DctQ component; Region: DctQ; cl01181
656519002744	DctM-like transporters; Region: DctM; pfam06808
656519002745	C4-dicarboxylate anaerobic carrier; Region: DcuC; cl15356
656519002746	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
656519002747	atypical (a) SDRs, subgroup 1; Region: SDR_a1; cd05265
656519002748	putative NAD(P) binding site [chemical binding]; other site
656519002749	active site
656519002750	ACT domain proteins similar to the yet uncharacterized Streptococcus pneumoniae ACT domain protein; Region: ACT_1ZPV; cd04872
656519002751	Uncharacterized proteins with similarity to Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL_like_DUF711; cd08025
656519002752	Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267
656519002753	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
656519002754	Transcriptional regulators [Transcription]; Region: GntR; COG1802
656519002755	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
656519002756	DNA-binding site [nucleotide binding]; DNA binding site
656519002757	FCD domain; Region: FCD; cl11656
656519002758	Transcriptional regulators [Transcription]; Region: GntR; COG1802
656519002759	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
656519002760	DNA-binding site [nucleotide binding]; DNA binding site
656519002761	FCD domain; Region: FCD; cl11656
656519002762	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
656519002763	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
656519002764	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
656519002765	dimer interface [polypeptide binding]; other site
656519002766	conserved gate region; other site
656519002767	putative PBP binding loops; other site
656519002768	ABC-ATPase subunit interface; other site
656519002769	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
656519002770	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
656519002771	dimer interface [polypeptide binding]; other site
656519002772	conserved gate region; other site
656519002773	putative PBP binding loops; other site
656519002774	ABC-ATPase subunit interface; other site
656519002775	mannonate dehydratase; Provisional; Region: PRK03906
656519002776	mannonate dehydratase; Region: uxuA; TIGR00695
656519002777	Mannitol-1-phosphate/altronate dehydrogenases [Carbohydrate transport and metabolism]; Region: MtlD; COG0246
656519002778	Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232
656519002779	Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125
656519002780	Galactose mutarotase and related enzymes [Carbohydrate transport and metabolism]; Region: GalM; COG2017
656519002781	galactose mutarotase_like; Region: galactose_mutarotase_like; cd09019
656519002782	active site
656519002783	catalytic residues [active]
656519002784	altronate oxidoreductase; Provisional; Region: PRK03643
656519002785	Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232
656519002786	Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125
656519002787	Glucuronate isomerase; Region: UxaC; cl00829
656519002788	SAF domain; Region: SAF; cl00555
656519002789	D-galactarate dehydratase / Altronate hydrolase, C terminus; Region: GD_AH_C; pfam04295
656519002790	Altronate dehydratase [Carbohydrate transport and metabolism]; Region: UxaA; COG2721
656519002791	Membrane transport protein; Region: Mem_trans; cl09117
656519002792	Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157
656519002793	Glycosyltransferases, probably involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG1215
656519002794	CESA_like_2 is a member of the cellulose synthase superfamily; Region: CESA_like_2; cd06427
656519002795	DXD motif; other site
656519002796	Transcriptional activator of acetoin/glycerol metabolism [Secondary metabolites biosynthesis, transport, and catabolism / Transcription]; Region: AcoR; COG3284
656519002797	GAF domain; Region: GAF; cl15785
656519002798	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
656519002799	putative active site [active]
656519002800	heme pocket [chemical binding]; other site
656519002801	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
656519002802	Walker A motif; other site
656519002803	ATP binding site [chemical binding]; other site
656519002804	Walker B motif; other site
656519002805	arginine finger; other site
656519002806	Helix-turn-helix domains; Region: HTH; cl00088
656519002807	pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_y; TIGR03182
656519002808	Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000
656519002809	tetramer interface [polypeptide binding]; other site
656519002810	TPP-binding site [chemical binding]; other site
656519002811	heterodimer interface [polypeptide binding]; other site
656519002812	phosphorylation loop region [posttranslational modification]
656519002813	Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022
656519002814	Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036
656519002815	alpha subunit interface [polypeptide binding]; other site
656519002816	TPP binding site [chemical binding]; other site
656519002817	heterodimer interface [polypeptide binding]; other site
656519002818	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
656519002819	Diacylglycerol kinase catalytic domain; Region: DAGK_cat; cl01255
656519002820	Methyltransferase domain; Region: Methyltransf_31; pfam13847
656519002821	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
656519002822	S-adenosylmethionine binding site [chemical binding]; other site
656519002823	branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856
656519002824	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
656519002825	E3 interaction surface; other site
656519002826	lipoyl attachment site [posttranslational modification]; other site
656519002827	2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; cl02008
656519002828	Methylmalonyl-CoA epimerase (MMCE); Region: MMCE; cd07249
656519002829	dimer interface [polypeptide binding]; other site
656519002830	substrate binding site [chemical binding]; other site
656519002831	metal binding site [ion binding]; metal-binding site
656519002832	Methylmalonyl-CoA epimerase (MMCE); Region: MMCE; cd07249
656519002833	dimer interface [polypeptide binding]; other site
656519002834	substrate binding site [chemical binding]; other site
656519002835	metal binding site [ion binding]; metal-binding site
656519002836	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
656519002837	(2R,3R)-2,3-butanediol dehydrogenase; Region: butanediol_DH_like; cd08233
656519002838	putative NAD(P) binding site [chemical binding]; other site
656519002839	catalytic Zn binding site [ion binding]; other site
656519002840	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
656519002841	classical (c) SDRs; Region: SDR_c; cd05233
656519002842	NAD(P) binding site [chemical binding]; other site
656519002843	active site
656519002844	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
656519002845	Coenzyme A binding pocket [chemical binding]; other site
656519002846	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
656519002847	IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639
656519002848	active site
656519002849	dimerization interface [polypeptide binding]; other site
656519002850	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
656519002851	S-adenosylmethionine binding site [chemical binding]; other site
656519002852	Fucose permease [Carbohydrate transport and metabolism]; Region: FucP; COG0738
656519002853	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
656519002854	putative substrate translocation pore; other site
656519002855	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
656519002856	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
656519002857	active site
656519002858	metal binding site [ion binding]; metal-binding site
656519002859	lipid transporter ATP-binding/permease protein; Provisional; Region: PRK11176
656519002860	5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872
656519002861	Transcriptional regulator containing PAS, AAA-type ATPase, and DNA-binding domains [Transcription / Signal transduction mechanisms]; Region: RocR; COG3829
656519002862	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
656519002863	Walker A motif; other site
656519002864	ATP binding site [chemical binding]; other site
656519002865	Walker B motif; other site
656519002866	arginine finger; other site
656519002867	Helix-turn-helix domains; Region: HTH; cl00088
656519002868	Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase (HisA) and the cyclase subunit of imidazoleglycerol phosphate synthase (HisF). The ProFAR isomerase catalyzes the fourth step in histidine biosynthesis, an...; Region: HisA_HisF; cd04723
656519002869	Histidine biosynthesis protein; Region: His_biosynth; pfam00977
656519002870	active site
656519002871	Archaeal flavoproteins [Energy production and conversion]; Region: COG1036
656519002872	Flavoprotein; Region: Flavoprotein; cl08021
656519002873	dihydropteroate synthase-related protein; Region: TIGR00284
656519002874	Pterin binding enzymes. This family includes dihydropteroate synthase (DHPS) and cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH).  DHPS, a...; Region: Pterin_binding; cl00219
656519002875	substrate binding pocket [chemical binding]; other site
656519002876	dimer interface [polypeptide binding]; other site
656519002877	inhibitor binding site; inhibition site
656519002878	Domain of unknown function (DUF4346); Region: DUF4346; pfam14251
656519002879	Flavin Reductases; Region: FlaRed; cl00801
656519002880	Predicted archaeal sugar kinases [General function prediction only]; Region: COG1907
656519002881	GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288
656519002882	GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544
656519002883	Uncharacterized protein conserved in archaea (DUF2193); Region: DUF2193; cl02034
656519002884	Methylene-tetrahydromethanopterin dehydrogenase, N-terminal; Region: Mpt_N; pfam09176
656519002885	NADP binding domain of methylene tetrahydromethanopterin dehydrogenase; Region: NAD_bind_H4MPT_DH; cd01078
656519002886	NADP binding site [chemical binding]; other site
656519002887	Predicted ATP-dependent carboligase related to biotin carboxylase [General function prediction only]; Region: COG2232
656519002888	ATP-grasp domain; Region: ATP-grasp_4; cl03087
656519002889	Molybdopterin-Binding, C-terminal (MopB_CT) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum-...; Region: MopB_CT; cl09929
656519002890	molybdopterin cofactor binding site; other site
656519002891	The MopB_FmdB-FwdB CD contains the molybdenum/tungsten formylmethanofuran dehydrogenases, subunit B (FmdB/FwdB), and other related proteins. Formylmethanofuran dehydrogenase catalyzes the first step in methane formation from CO2 in methanogenic archaea...; Region: MopB_FmdB-FwdB; cd02761
656519002892	formylmethanofuran dehydrogenase subunit B; Region: one_C_dehyd_B; TIGR03129
656519002893	putative [4Fe-4S] binding site [ion binding]; other site
656519002894	putative molybdopterin cofactor binding site [chemical binding]; other site
656519002895	formylmethanofuran dehydrogenase subunit A; Region: one_C_dehyd_A; TIGR03121
656519002896	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
656519002897	active site
656519002898	formylmethanofuran--tetrahydromethanopterin formyltransferase; Provisional; Region: PRK02114
656519002899	Formylmethanofuran-tetrahydromethanopterin formyltransferase; Region: FTR; pfam01913
656519002900	FTR, proximal lobe; Region: FTR_C; pfam02741
656519002901	GXGXG domain. This domain of unknown function is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS),  in subunit C of tungsten formylmethanofuran dehydrogenase (FwdC) and in subunit C of molybdenum formylmethanofuran...; Region: GXGXG; cl00239
656519002902	domain_subunit interface; other site
656519002903	N(5),N(10)-methenyltetrahydromethanopterin cyclohydrolase; Provisional; Region: PRK02264
656519002904	Methenyltetrahydromethanopterin (methenyl-H4MPT) cyclohydrolase (MCH). MCH is a cytoplasmic enzyme that has been identified in methanogenic archaea, sulfate- reducing archaea, and methylotrophic bacteria.  It catalyzes the reversible formation of N(5), N...; Region: MCH; cd00545
656519002905	trimer interface I [polypeptide binding]; other site
656519002906	putative substrate binding pocket [chemical binding]; other site
656519002907	trimer interface II [polypeptide binding]; other site
656519002908	alpha-L-glutamate ligases, RimK family; Region: rimK_fam; TIGR00768
656519002909	ATP-grasp domain; Region: ATP-grasp_4; cl03087
656519002910	ATP:dephospho-CoA triphosphoribosyl transferase; Region: CitG; cl00768
656519002911	Type I GTP cyclohydrolase folE2; Region: GCHY-1; cl00642
656519002912	Protein of unknown function (DUF556); Region: DUF556; cl00822
656519002913	Hydantoinase/oxoprolinase; Region: Hydantoinase_A; cl00668
656519002914	Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452
656519002915	nucleotide binding site [chemical binding]; other site
656519002916	substrate binding site [chemical binding]; other site
656519002917	ADP-ribosylglycohydrolase; Region: ADP_ribosyl_GH; cl00614
656519002918	DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739
656519002919	dihydropteroate synthase; Region: DHPS; TIGR01496
656519002920	substrate binding pocket [chemical binding]; other site
656519002921	dimer interface [polypeptide binding]; other site
656519002922	inhibitor binding site; inhibition site
656519002923	Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534
656519002924	homooctamer interface [polypeptide binding]; other site
656519002925	active site
656519002926	7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483
656519002927	catalytic center binding site [active]
656519002928	ATP binding site [chemical binding]; other site
656519002929	ATP-grasp domain; Region: ATP-grasp_4; cl03087
656519002930	Sodium:dicarboxylate symporter family; Region: SDF; cl00573
656519002931	OAH/OAS sulfhydrylase; Region: OAH_OAS_sulfhy; TIGR01326
656519002932	CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614
656519002933	homodimer interface [polypeptide binding]; other site
656519002934	substrate-cofactor binding pocket; other site
656519002935	pyridoxal 5'-phosphate binding site [chemical binding]; other site
656519002936	catalytic residue [active]
656519002937	Homoserine O-succinyltransferase; Region: HTS; pfam04204
656519002938	Type 1 glutamine amidotransferase (GATase1)-like domain found in homoserine trans-succinylase (HTS); Region: GATase1_HTS; cd03131
656519002939	proposed active site lysine [active]
656519002940	conserved cys residue [active]
656519002941	Phosphorylase superfamily; Region: PNP_UDP_1; cl00303
656519002942	Uridine phosphorylase [Nucleotide transport and metabolism]; Region: Udp; COG2820
656519002943	Haemolysin-III related; Region: HlyIII; cl03831
656519002944	Sigma-54 factor, Activator interacting domain (AID); Region: Sigma54_AID; pfam00309
656519002945	RNA polymerase sigma-54 factor; Region: rpoN_sigma; TIGR02395
656519002946	Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963
656519002947	Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963
656519002948	Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552
656519002949	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
656519002950	dimer interface [polypeptide binding]; other site
656519002951	conserved gate region; other site
656519002952	putative PBP binding loops; other site
656519002953	ABC-ATPase subunit interface; other site
656519002954	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
656519002955	dimer interface [polypeptide binding]; other site
656519002956	conserved gate region; other site
656519002957	putative PBP binding loops; other site
656519002958	ABC-ATPase subunit interface; other site
656519002959	Predicted transcriptional regulator [Transcription]; Region: COG2378
656519002960	Helix-turn-helix domains; Region: HTH; cl00088
656519002961	WYL domain; Region: WYL; cl14852
656519002962	Macrophage migration inhibitory factor (MIF); Region: MIF; pfam01187
656519002963	The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a...; Region: PMM_PGM; cd03089
656519002964	phosphomannomutase/phosphoglucomutase; Reviewed; Region: manB; PRK09542
656519002965	active site
656519002966	substrate binding site [chemical binding]; other site
656519002967	metal binding site [ion binding]; metal-binding site
656519002968	Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer,  utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514
656519002969	FMN binding site [chemical binding]; other site
656519002970	dimer interface [polypeptide binding]; other site
656519002971	Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer,  utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514
656519002972	dimer interface [polypeptide binding]; other site
656519002973	Predicted oxidoreductases of the aldo/keto reductase family [General function prediction only]; Region: COG1453
656519002974	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
656519002975	active site
656519002976	catalytic tetrad [active]
656519002977	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
656519002978	putative lipid kinase; Reviewed; Region: PRK13059
656519002979	Diacylglycerol kinase catalytic domain; Region: DAGK_cat; cl01255
656519002980	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
656519002981	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
656519002982	Uncharacterized BCR, COG1649; Region: DUF187; cl15398
656519002983	YKOF-related Family; Region: Ykof; pfam07615
656519002984	SpoIVFB Site-2 protease (S2P), a zinc metalloprotease (MEROPS family M50B), regulates intramembrane proteolysis (RIP), and is involved in the pro-sigmaK pathway of bacterial spore formation. In this subgroup, SpoIVFB (sporulation protein, stage IV cell...; Region: S2P-M50_SpoIVFB_CBS; cd06164
656519002985	active site
656519002986	putative substrate binding region [chemical binding]; other site
656519002987	FOG: CBS domain [General function prediction only]; Region: COG0517
656519002988	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with either the SpoIVFB domain (sporulation protein, stage IV cell wall formation, F locus, promoter-distal B) or the chloride channel protein EriC; Region: CBS_pair_SpoIVFB_EriC_assoc; cd04612
656519002989	Sensory domain found in PocR; Region: PocR; pfam10114
656519002990	Predicted sensor domain [Signal transduction mechanisms / Transcription]; Region: PocR; COG4936
656519002991	Histidine kinase; Region: His_kinase; pfam06580
656519002992	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
656519002993	ATP binding site [chemical binding]; other site
656519002994	Mg2+ binding site [ion binding]; other site
656519002995	G-X-G motif; other site
656519002996	Response regulator containing CheY-like receiver domain and AraC-type DNA-binding domain [Signal transduction mechanisms]; Region: COG4753
656519002997	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
656519002998	active site
656519002999	phosphorylation site [posttranslational modification]
656519003000	intermolecular recognition site; other site
656519003001	dimerization interface [polypeptide binding]; other site
656519003002	DNA-binding transcriptional regulator MelR; Provisional; Region: PRK10371
656519003003	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
656519003004	Carbon dioxide concentrating mechanism K (CcmK)-like proteins, Bacterial Micro-Compartment (BMC) domain; Region: BMC_CcmK_like; cd07045
656519003005	Hexamer interface [polypeptide binding]; other site
656519003006	Hexagonal pore residue; other site
656519003007	propanediol utilization protein PduB; Provisional; Region: PRK15415
656519003008	1,2-propanediol utilization protein B (PduB), Bacterial Micro-Compartment (BMC) domain repeat 1; Region: BMC_PduB_repeat1; cd07047
656519003009	putative hexamer interface [polypeptide binding]; other site
656519003010	putative hexagonal pore; other site
656519003011	1,2-propanediol utilization protein B (PduB), Bacterial Micro-Compartment (BMC) domain repeat 2; Region: BMC_PduB_repeat2; cd07048
656519003012	putative hexamer interface [polypeptide binding]; other site
656519003013	putative hexagonal pore; other site
656519003014	Dehydratase large subunit. This family contains the large (alpha) subunit of B12-dependent glycerol dehydratases (GDHs) and B12-dependent diol dehydratases (DDHs). GDH is isofunctional with DDH. These enzymes can each catalyze the conversion of 1; Region: Dehydratase_LU; cl12104
656519003015	alpha-alpha subunit/dimer interface [polypeptide binding]; other site
656519003016	alpha-beta subunit interface [polypeptide binding]; other site
656519003017	alpha-gamma subunit interface [polypeptide binding]; other site
656519003018	active site
656519003019	substrate and K+ binding site; other site
656519003020	K+ binding site [ion binding]; other site
656519003021	cobalamin binding site [chemical binding]; other site
656519003022	propanediol dehydratase medium subunit; Provisional; Region: pduD; PRK15042
656519003023	Dehydratase medium subunit; Region: Dehydratase_MU; pfam02288
656519003024	Dehydratase small subunit; Region: Dehydratase_SU; cl02055
656519003025	Cell division ATPase FtsA [Cell division and chromosome partitioning]; Region: ftsA; COG0849
656519003026	Diol dehydratase reactivase ATPase-like domain; Region: DDR; pfam08841
656519003027	Dehydratase medium subunit; Region: Dehydratase_MU; pfam02288
656519003028	Carbon dioxide concentrating mechanism K (CcmK)-like proteins, Bacterial Micro-Compartment (BMC) domain; Region: BMC_CcmK_like; cd07045
656519003029	Hexamer interface [polypeptide binding]; other site
656519003030	Hexagonal pore residue; other site
656519003031	Carbon dioxide concentrating mechanism K (CcmK)-like proteins, Bacterial Micro-Compartment (BMC) domain; Region: BMC_CcmK_like; cd07045
656519003032	Hexamer interface [polypeptide binding]; other site
656519003033	Hexagonal pore residue; other site
656519003034	ethanolamine utilization protein EutJ; Provisional; Region: PRK15080
656519003035	Flavoprotein; Region: Flavoprotein; cl08021
656519003036	ethanolamine utilization protein; Region: eut_hyp; TIGR02536
656519003037	Ethanolamine utilisation protein and carboxysome structural protein domain family; Region: EutN_CcmL; cd01614
656519003038	Hexamer/Pentamer interface [polypeptide binding]; other site
656519003039	central pore; other site
656519003040	Cobalamin adenosyltransferase; Region: Cob_adeno_trans; cl00920
656519003041	Domain of unknown function (DUF336); Region: DUF336; cl01249
656519003042	Ethanolamine utilization protein EutE-like; Region: ALDH_EutE; cd07121
656519003043	putative catalytic cysteine [active]
656519003044	Respiratory-chain NADH dehydrogenase 51 Kd subunit; Region: Complex1_51K; pfam01512
656519003045	SLBB domain; Region: SLBB; pfam10531
656519003046	4Fe-4S dicluster domain; Region: Fer4_17; pfam13534
656519003047	RnfC Barrel sandwich hybrid domain; Region: RnfC_N; pfam13375
656519003048	ethanolamine utilization protein, PduT homolog; Region: eut_PduT; TIGR02526
656519003049	1,2-propanediol utilization protein T (PduT), Bacterial Micro-Compartment (BMC) domain repeat 1; Region: BMC_PduT_repeat1; cd07053
656519003050	putative hexamer interface [polypeptide binding]; other site
656519003051	putative hexagonal pore; other site
656519003052	1,2-propanediol utilization protein T (PduT), Bacterial Micro-Compartment (BMC) domain repeat 2; Region: BMC_PduT_repeat2; cd07054
656519003053	putative hexamer interface [polypeptide binding]; other site
656519003054	putative hexagonal pore; other site
656519003055	Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454
656519003056	Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872
656519003057	active site
656519003058	NAD binding site [chemical binding]; other site
656519003059	metal binding site [ion binding]; metal-binding site
656519003060	Acetokinase family; Region: Acetate_kinase; cl01029
656519003061	propionate/acetate kinase; Provisional; Region: PRK12379
656519003062	1,2-propanediol utilization protein U (PduU)/ethanolamine utilization protein S (EutS), Bacterial Micro-Compartment (BMC) domain; Region: BMC_PduU-EutS; cd07046
656519003063	putative hexamer interface [polypeptide binding]; other site
656519003064	putative hexagonal pore; other site
656519003065	Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882
656519003066	G1 box; other site
656519003067	GTP/Mg2+ binding site [chemical binding]; other site
656519003068	Switch I region; other site
656519003069	G3 box; other site
656519003070	Switch II region; other site
656519003071	G4 box; other site
656519003072	G5 box; other site
656519003073	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
656519003074	propanediol utilization phosphotransacylase; Provisional; Region: PRK15070
656519003075	Propanediol utilisation protein PduL; Region: PduL; pfam06130
656519003076	Propanediol utilisation protein PduL; Region: PduL; pfam06130
656519003077	Predicted membrane protein (DUF2177); Region: DUF2177; cl02014
656519003078	CpxP component of the bacterial Cpx-two-component system and related proteins; Region: CpxP_like; cd09916
656519003079	dimer interface [polypeptide binding]; other site
656519003080	Domain of unknown function (DUF389); Region: DUF389; cl00781
656519003081	Uncharacterized protein conserved in bacteria (DUF2325); Region: DUF2325; cl01811
656519003082	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
656519003083	Arylsulfatase regulator (Fe-S oxidoreductase) [General function prediction only]; Region: AslB; COG0641
656519003084	FeS/SAM binding site; other site
656519003085	Domain of unknown function (DUF4008); Region: DUF4008; cl14869
656519003086	Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917
656519003087	NodB motif; other site
656519003088	active site
656519003089	catalytic site [active]
656519003090	metal binding site [ion binding]; metal-binding site
656519003091	Protein of unknown function DUF89; Region: DUF89; cl15397
656519003092	B12 binding domain of corrinoid proteins. A family of small methanogenic corrinoid proteins that bind methyl-Co(III) 5-hydroxybenzimidazolylcobamide as a cofactor. They play a role on the methanogenesis from trimethylamine, dimethylamine or...; Region: corrinoid_protein_B12-BD; cd02070
656519003093	B12 binding site [chemical binding]; other site
656519003094	cobalt ligand [ion binding]; other site
656519003095	Predicted sensor domain [Signal transduction mechanisms / Transcription]; Region: PocR; COG4936
656519003096	Sensory domain found in PocR; Region: PocR; pfam10114
656519003097	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
656519003098	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
656519003099	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
656519003100	Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070
656519003101	uncharacterized xylulose kinase-like proteins, subgroup 1; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_XK_like_1; cd07804
656519003102	N- and C-terminal domain interface [polypeptide binding]; other site
656519003103	putative active site [active]
656519003104	catalytic site [active]
656519003105	metal binding site [ion binding]; metal-binding site
656519003106	putative xylulose binding site [chemical binding]; other site
656519003107	putative ATP binding site [chemical binding]; other site
656519003108	putative homodimer interface [polypeptide binding]; other site
656519003109	The URO-D_CIMS_like protein superfamily includes bacterial and eukaryotic uroporphyrinogen decarboxylases (URO-D), coenzyme M methyltransferases and other putative bacterial methyltransferases, as well as cobalamine (B12) independent methionine synthases; Region: URO-D_CIMS_like; cl00464
656519003110	The URO-D _like protein superfamily includes bacterial and eukaryotic uroporphyrinogen decarboxylases (URO-D), coenzyme M methyltransferases and other putative bacterial methyltransferases. Uroporphyrinogen decarboxylase (URO-D) decarboxylates the four...; Region: URO-D_like; cd03465
656519003111	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
656519003112	Putative GTPases (G3E family) [General function prediction only]; Region: COG0523
656519003113	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
656519003114	Helix-turn-helix domains; Region: HTH; cl00088
656519003115	putative transposase OrfB; Reviewed; Region: PHA02517
656519003116	HTH-like domain; Region: HTH_21; pfam13276
656519003117	Integrase core domain; Region: rve; cl01316
656519003118	Integrase core domain; Region: rve_3; cl15866
656519003119	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
656519003120	Helix-turn-helix domains; Region: HTH; cl00088
656519003121	Domain of unknown function DUF20; Region: UPF0118; pfam01594
656519003122	pheromone autoinducer 2 transporter; Reviewed; Region: tqsA; cl00465
656519003123	Transposase, Mutator family; Region: Transposase_mut; pfam00872
656519003124	MULE transposase domain; Region: MULE; pfam10551
656519003125	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584
656519003126	transposase; Provisional; Region: PRK06526
656519003127	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
656519003128	Walker A motif; other site
656519003129	ATP binding site [chemical binding]; other site
656519003130	Walker B motif; other site
656519003131	Loader and inhibitor of phage G40P; Region: Inhibitor_G39P; pfam11417
656519003132	YvrJ protein family; Region: YvrJ; pfam12841
656519003133	Helix-turn-helix domains; Region: HTH; cl00088
656519003134	HTH-like domain; Region: HTH_21; pfam13276
656519003135	Integrase core domain; Region: rve; cl01316
656519003136	Integrase core domain; Region: rve_3; cl15866
656519003137	Protein of unknown function DUF262; Region: DUF262; cl14890
656519003138	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
656519003139	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
656519003140	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
656519003141	ATP binding site [chemical binding]; other site
656519003142	putative Mg++ binding site [ion binding]; other site
656519003143	Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210
656519003144	Family description; Region: UvrD_C_2; cl15862
656519003145	putative recombination protein RecB; Provisional; Region: PRK13909
656519003146	CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641
656519003147	Transposase, Mutator family; Region: Transposase_mut; pfam00872
656519003148	MULE transposase domain; Region: MULE; pfam10551
656519003149	Uncharacterized protein conserved in bacteria (DUF2225); Region: DUF2225; pfam09986
656519003150	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: VicK; COG5002
656519003151	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
656519003152	dimerization interface [polypeptide binding]; other site
656519003153	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459
656519003154	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
656519003155	dimer interface [polypeptide binding]; other site
656519003156	phosphorylation site [posttranslational modification]
656519003157	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
656519003158	ATP binding site [chemical binding]; other site
656519003159	Mg2+ binding site [ion binding]; other site
656519003160	G-X-G motif; other site
656519003161	Response regulator receiver domain; Region: Response_reg; pfam00072
656519003162	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
656519003163	active site
656519003164	phosphorylation site [posttranslational modification]
656519003165	intermolecular recognition site; other site
656519003166	dimerization interface [polypeptide binding]; other site
656519003167	Response regulator receiver domain; Region: Response_reg; pfam00072
656519003168	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
656519003169	active site
656519003170	phosphorylation site [posttranslational modification]
656519003171	intermolecular recognition site; other site
656519003172	dimerization interface [polypeptide binding]; other site
656519003173	Tetratricopeptide repeat; Region: TPR_16; pfam13432
656519003174	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
656519003175	TPR motif; other site
656519003176	binding surface
656519003177	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
656519003178	K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569
656519003179	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
656519003180	Anion permease ArsB/NhaD.  These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life.  A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl15357
656519003181	Cation transport protein; Region: TrkH; cl10514
656519003182	potassium uptake protein, TrkH family; Region: 2a38; TIGR00933
656519003183	putative inner membrane protein; Provisional; Region: PRK11099
656519003184	Sulphur transport; Region: Sulf_transp; cl01018
656519003185	Anion permease ArsB/NhaD.  These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life.  A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl15357
656519003186	transmembrane helices; other site
656519003187	Anion permease ArsB/NhaD.  These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life.  A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl15357
656519003188	Anion permease ArsB/NhaD.  These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life.  A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl15357
656519003189	HIRAN domain; Region: HIRAN; cl07418
656519003190	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
656519003191	Response regulator receiver domain; Region: Response_reg; pfam00072
656519003192	active site
656519003193	phosphorylation site [posttranslational modification]
656519003194	intermolecular recognition site; other site
656519003195	dimerization interface [polypeptide binding]; other site
656519003196	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
656519003197	putative active site [active]
656519003198	heme pocket [chemical binding]; other site
656519003199	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
656519003200	PAS fold; Region: PAS_3; pfam08447
656519003201	putative active site [active]
656519003202	heme pocket [chemical binding]; other site
656519003203	GAF domain; Region: GAF; cl15785
656519003204	GAF domain; Region: GAF_2; pfam13185
656519003205	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
656519003206	c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206
656519003207	metal binding site [ion binding]; metal-binding site
656519003208	active site
656519003209	I-site; other site
656519003210	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
656519003211	Zn2+ binding site [ion binding]; other site
656519003212	Mg2+ binding site [ion binding]; other site
656519003213	PAS fold; Region: PAS_4; pfam08448
656519003214	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
656519003215	putative active site [active]
656519003216	heme pocket [chemical binding]; other site
656519003217	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459
656519003218	PAS domain; Region: PAS_9; pfam13426
656519003219	GAF domain; Region: GAF_2; pfam13185
656519003220	PAS domain S-box; Region: sensory_box; TIGR00229
656519003221	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
656519003222	putative active site [active]
656519003223	heme pocket [chemical binding]; other site
656519003224	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
656519003225	metal binding site [ion binding]; metal-binding site
656519003226	active site
656519003227	I-site; other site
656519003228	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
656519003229	Zn2+ binding site [ion binding]; other site
656519003230	Mg2+ binding site [ion binding]; other site
656519003231	circadian clock protein KaiC; Reviewed; Region: PRK09302
656519003232	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
656519003233	ATP binding site [chemical binding]; other site
656519003234	Walker B motif; other site
656519003235	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
656519003236	ATP binding site [chemical binding]; other site
656519003237	Walker B motif; other site
656519003238	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
656519003239	metal binding site [ion binding]; metal-binding site
656519003240	active site
656519003241	I-site; other site
656519003242	c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206
656519003243	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076
656519003244	glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK05293
656519003245	ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508
656519003246	ligand binding site; other site
656519003247	oligomer interface; other site
656519003248	Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651
656519003249	dimer interface [polypeptide binding]; other site
656519003250	N-terminal domain interface [polypeptide binding]; other site
656519003251	sulfate 1 binding site; other site
656519003252	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
656519003253	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
656519003254	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
656519003255	Cellulase (glycosyl hydrolase family 5); Region: Cellulase; cl15381
656519003256	Helix-turn-helix domains; Region: HTH; cl00088
656519003257	putative transposase OrfB; Reviewed; Region: PHA02517
656519003258	HTH-like domain; Region: HTH_21; pfam13276
656519003259	Integrase core domain; Region: rve; cl01316
656519003260	Integrase core domain; Region: rve_3; cl15866
656519003261	beta-D-glucuronidase; Provisional; Region: PRK10150
656519003262	Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; cl08371
656519003263	Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703
656519003264	Cellulase (glycosyl hydrolase family 5); Region: Cellulase; cl15381
656519003265	Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971
656519003266	Alpha amylase catalytic domain found in an uncharacterized protein family; Region: AmyAc_5; cd11352
656519003267	active site
656519003268	catalytic site [active]
656519003269	HD supefamily hydrolase [General function prediction only]; Region: COG3294
656519003270	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076
656519003271	FxsA cytoplasmic membrane protein; Region: FxsA; cl01148
656519003272	Zinc dependent phospholipase C; Region: Zn_dep_PLPC; cl03005
656519003273	RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398
656519003274	tetramer (dimer of dimers) interface [polypeptide binding]; other site
656519003275	active site
656519003276	dimer interface [polypeptide binding]; other site
656519003277	Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of  glutathione (GSH) with a wide range of endogenous and xenobiotic...; Region: GST_N_family; cd00570
656519003278	C-terminal domain interface [polypeptide binding]; other site
656519003279	GSH binding site (G-site) [chemical binding]; other site
656519003280	dimer interface [polypeptide binding]; other site
656519003281	Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118
656519003282	putative peptidoglycan binding site; other site
656519003283	Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118
656519003284	putative peptidoglycan binding site; other site
656519003285	Peptidase family M23; Region: Peptidase_M23; pfam01551
656519003286	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217
656519003287	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
656519003288	metal-binding site [ion binding]
656519003289	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
656519003290	Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391
656519003291	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
656519003292	dimerization interface [polypeptide binding]; other site
656519003293	putative DNA binding site [nucleotide binding]; other site
656519003294	putative Zn2+ binding site [ion binding]; other site
656519003295	Methyltransferase domain; Region: Methyltransf_31; pfam13847
656519003296	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
656519003297	S-adenosylmethionine binding site [chemical binding]; other site
656519003298	MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503
656519003299	molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317
656519003300	GTP binding site; other site
656519003301	valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729
656519003302	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
656519003303	active site
656519003304	HIGH motif; other site
656519003305	nucleotide binding site [chemical binding]; other site
656519003306	Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603
656519003307	catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817
656519003308	active site
656519003309	KMSKS motif; other site
656519003310	Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962
656519003311	tRNA binding surface [nucleotide binding]; other site
656519003312	anticodon binding site; other site
656519003313	Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458
656519003314	Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471
656519003315	Anion permease ArsB/NhaD.  These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life.  A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl15357
656519003316	Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303
656519003317	MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887
656519003318	dimer interface [polypeptide binding]; other site
656519003319	putative functional site; other site
656519003320	putative MPT binding site; other site
656519003321	putative molybdopterin biosynthesis protein MoeA/LysR substrate binding-domain-containing protein; Provisional; Region: PRK14498
656519003322	MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887
656519003323	dimer interface [polypeptide binding]; other site
656519003324	putative functional site; other site
656519003325	putative MPT binding site; other site
656519003326	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
656519003327	molybdenum cofactor biosynthesis protein A; Reviewed; Region: moaA; PRK00164
656519003328	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
656519003329	FeS/SAM binding site; other site
656519003330	Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463
656519003331	MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420
656519003332	trimer interface [polypeptide binding]; other site
656519003333	dimer interface [polypeptide binding]; other site
656519003334	putative active site [active]
656519003335	MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886
656519003336	MPT binding site; other site
656519003337	trimer interface [polypeptide binding]; other site
656519003338	MOSC domain; Region: MOSC; pfam03473
656519003339	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
656519003340	3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352
656519003341	Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830
656519003342	dimer interface [polypeptide binding]; other site
656519003343	active site
656519003344	CoA binding pocket [chemical binding]; other site
656519003345	Acyl transferase domain; Region: Acyl_transf_1; cl08282
656519003346	malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128
656519003347	beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150
656519003348	Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834
656519003349	dimer interface [polypeptide binding]; other site
656519003350	active site
656519003351	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
656519003352	Asp23 family; Region: Asp23; cl00574
656519003353	Trehalose and maltose hydrolases (possible phosphorylases) [Carbohydrate transport and metabolism]; Region: ATH1; COG1554
656519003354	Glycosyl hydrolase family 65, N-terminal domain; Region: Glyco_hydro_65N; pfam03636
656519003355	Glycosyl hydrolase family 65 central catalytic domain; Region: Glyco_hydro_65m; pfam03632
656519003356	Glycosyl hydrolase family 65, C-terminal domain; Region: Glyco_hydro_65C; pfam03633
656519003357	EamA-like transporter family; Region: EamA; cl01037
656519003358	Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950
656519003359	EamA-like transporter family; Region: EamA; cl01037
656519003360	transketolase; Reviewed; Region: PRK05899
656519003361	Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012
656519003362	TPP-binding site [chemical binding]; other site
656519003363	dimer interface [polypeptide binding]; other site
656519003364	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
656519003365	PYR/PP interface [polypeptide binding]; other site
656519003366	dimer interface [polypeptide binding]; other site
656519003367	TPP binding site [chemical binding]; other site
656519003368	Divergent PAP2 family; Region: DUF212; cl00855
656519003369	Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285
656519003370	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
656519003371	Sporulation related domain; Region: SPOR; cl10051
656519003372	electron transport complex, RnfABCDGE type, C subunit; Region: rnfC; TIGR01945
656519003373	RnfC Barrel sandwich hybrid domain; Region: RnfC_N; pfam13375
656519003374	Respiratory-chain NADH dehydrogenase 51 Kd subunit; Region: Complex1_51K; pfam01512
656519003375	SLBB domain; Region: SLBB; pfam10531
656519003376	4Fe-4S binding domain; Region: Fer4; cl02805
656519003377	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
656519003378	NQR2, RnfD, RnfE family; Region: NQR2_RnfD_RnfE; cl00779
656519003379	FMN-binding domain; Region: FMN_bind; cl01081
656519003380	Rnf-Nqr subunit, membrane protein; Region: Rnf-Nqr; cl00597
656519003381	Rnf-Nqr subunit, membrane protein; Region: Rnf-Nqr; cl00597
656519003382	ferredoxin; Validated; Region: PRK07118
656519003383	4Fe-4S binding domain; Region: Fer4; cl02805
656519003384	4Fe-4S binding domain; Region: Fer4; cl02805
656519003385	4Fe-4S dicluster domain; Region: Fer4_10; pfam13237
656519003386	RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409
656519003387	4Fe-4S dicluster domain; Region: Fer4_7; pfam12838
656519003388	RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651
656519003389	Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078
656519003390	putative active site [active]
656519003391	putative NTP binding site [chemical binding]; other site
656519003392	putative nucleic acid binding site [nucleotide binding]; other site
656519003393	Group II intron, maturase-specific domain; Region: GIIM; pfam08388
656519003394	N-Utilization Substance G (NusG) N terminal (NGN) insert and Lin0431 are part of DUF1312; Region: DUF1312; cd09846
656519003395	Heptaprenyl diphosphate synthase component I; Region: Hpre_diP_synt_I; cl01973
656519003396	Maf-like protein; Region: Maf; pfam02545
656519003397	Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555
656519003398	active site
656519003399	dimer interface [polypeptide binding]; other site
656519003400	hypothetical protein; Reviewed; Region: PRK00024
656519003401	Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071
656519003402	MPN+ (JAMM) motif; other site
656519003403	Zinc-binding site [ion binding]; other site
656519003404	rod shape-determining protein MreB; Provisional; Region: PRK13927
656519003405	Ppx/GppA phosphatase family; Region: Ppx-GppA; cl15449
656519003406	Cell division protein FtsA; Region: FtsA; cl11496
656519003407	rod shape-determining protein MreC; Region: MreC; pfam04085
656519003408	rod shape-determining protein MreD; Region: MreD; cl01087
656519003409	penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423
656519003410	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
656519003411	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009
656519003412	Septum formation inhibitor [Cell division and chromosome partitioning]; Region: MinC; COG0850
656519003413	Septum formation inhibitor MinC, C-terminal domain; Region: MinC_C; pfam03775
656519003414	septum site-determining protein MinD; Region: minD_bact; TIGR01968
656519003415	Bacterial cell division requires the formation of a septum at mid-cell. The site is determined by the min operon products MinC, MinD and MinE. MinC is a nonspecific inhibitor of the septum protein FtsZ. MinE is the supressor of MinC. MinD plays a pivotal...; Region: MinD; cd02036
656519003416	Switch I; other site
656519003417	Switch II; other site
656519003418	Septum formation topological specificity factor MinE; Region: MinE; cl00538
656519003419	Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511
656519003420	radical SAM family uncharacterized protein; Region: rSAM_fuse_unch; TIGR03960
656519003421	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
656519003422	FeS/SAM binding site; other site
656519003423	radical SAM-linked protein; Region: sam_1_link_chp; TIGR03936
656519003424	Uncharacterized protein conserved in bacteria (DUF2344); Region: DUF2344; cl02090
656519003425	ribonuclease, Rne/Rng family; Region: RNaseEG; TIGR00757
656519003426	S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453
656519003427	homodimer interface [polypeptide binding]; other site
656519003428	oligonucleotide binding site [chemical binding]; other site
656519003429	K homology RNA-binding domain, type I.  KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains that...; Region: KH-I; cl00098
656519003430	nucleic acid binding region [nucleotide binding]; other site
656519003431	G-X-X-G motif; other site
656519003432	TRAM domain; Region: TRAM; cl01282
656519003433	Ribosomal prokaryotic L21 protein; Region: Ribosomal_L21p; cl00382
656519003434	Ribosomal L27 protein; Region: Ribosomal_L27; cl00359
656519003435	GTPase CgtA; Reviewed; Region: obgE; PRK12297
656519003436	GTP1/OBG; Region: GTP1_OBG; pfam01018
656519003437	Obg GTPase; Region: Obg; cd01898
656519003438	G1 box; other site
656519003439	GTP/Mg2+ binding site [chemical binding]; other site
656519003440	Switch I region; other site
656519003441	G2 box; other site
656519003442	G3 box; other site
656519003443	Switch II region; other site
656519003444	G4 box; other site
656519003445	G5 box; other site
656519003446	Domain of unknown function (DUF1967); Region: DUF1967; cl07779
656519003447	CRS1 / YhbY (CRM) domain; Region: CRS1_YhbY; cl00663
656519003448	Uncharacterized protein, DegV family COG1307; Region: DegV; cl00577
656519003449	ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488
656519003450	ABCF_EF-3  Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth.  EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221
656519003451	ABCF_EF-3  Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth.  EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221
656519003452	ABC transporter; Region: ABC_tran_2; pfam12848
656519003453	ABCF_EF-3  Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth.  EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221
656519003454	Nitrogen regulatory protein P-II; Region: P-II; cl00412
656519003455	Nitrogen regulatory protein P-II; Region: P-II; smart00938
656519003456	Ammonium Transporter Family; Region: Ammonium_transp; cl03012
656519003457	NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553
656519003458	NAD synthase; Region: NAD_synthase; pfam02540
656519003459	homodimer interface [polypeptide binding]; other site
656519003460	NAD binding pocket [chemical binding]; other site
656519003461	ATP binding pocket [chemical binding]; other site
656519003462	Mg binding site [ion binding]; other site
656519003463	active-site loop [active]
656519003464	glutamine synthetase, type I; Region: GlnA; TIGR00653
656519003465	Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951
656519003466	Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120
656519003467	acetolactate synthase, large subunit, biosynthetic type; Region: acolac_lg; TIGR00118
656519003468	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
656519003469	PYR/PP interface [polypeptide binding]; other site
656519003470	dimer interface [polypeptide binding]; other site
656519003471	TPP binding site [chemical binding]; other site
656519003472	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; cl00815
656519003473	Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015
656519003474	TPP-binding site [chemical binding]; other site
656519003475	dimer interface [polypeptide binding]; other site
656519003476	Sulfatase; Region: Sulfatase; cl10460
656519003477	riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326
656519003478	Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284
656519003479	catalytic motif [active]
656519003480	Zn binding site [ion binding]; other site
656519003481	Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cl00161
656519003482	riboflavin synthase subunit alpha; Provisional; Region: PRK09289
656519003483	Lumazine binding domain; Region: Lum_binding; pfam00677
656519003484	Lumazine binding domain; Region: Lum_binding; pfam00677
656519003485	bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09311
656519003486	3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; cl00336
656519003487	GTP cyclohydrolase II (RibA).  GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641
656519003488	dimerization interface [polypeptide binding]; other site
656519003489	active site
656519003490	lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209
656519003491	homopentamer interface [polypeptide binding]; other site
656519003492	active site
656519003493	glycerol kinase; Provisional; Region: glpK; PRK00047
656519003494	Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786
656519003495	N- and C-terminal domain interface [polypeptide binding]; other site
656519003496	active site
656519003497	MgATP binding site [chemical binding]; other site
656519003498	catalytic site [active]
656519003499	metal binding site [ion binding]; metal-binding site
656519003500	glycerol binding site [chemical binding]; other site
656519003501	homotetramer interface [polypeptide binding]; other site
656519003502	homodimer interface [polypeptide binding]; other site
656519003503	FBP binding site [chemical binding]; other site
656519003504	protein IIAGlc interface [polypeptide binding]; other site
656519003505	Predicted dehydrogenase [General function prediction only]; Region: COG0579
656519003506	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
656519003507	BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; cl01093
656519003508	Peptide methionine sulfoxide reductase; Region: PMSR; cl00366
656519003509	methionine sulfoxide reductase B; Provisional; Region: PRK00222; cl15841
656519003510	Conserved domain frequently associated with peptide methionine sulfoxide reductase [Posttranslational modification, protein turnover, chaperones]; Region: COG0229
656519003511	Predicted permease [General function prediction only]; Region: COG2056
656519003512	Na+-H+ antiporter family; Region: Na_H_antiport_2; cl15264
656519003513	Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109
656519003514	The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a...; Region: PMM_PGM; cd03089
656519003515	active site
656519003516	substrate binding site [chemical binding]; other site
656519003517	metal binding site [ion binding]; metal-binding site
656519003518	Predicted oxidoreductases (related to aryl-alcohol dehydrogenases) [Energy production and conversion]; Region: Tas; COG0667
656519003519	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
656519003520	active site
656519003521	catalytic tetrad [active]
656519003522	Sporulation protein YtfJ (Spore_YtfJ); Region: Spore_YtfJ; cl01596
656519003523	Threonine synthase [Amino acid transport and metabolism]; Region: ThrC; COG0498
656519003524	Threonine synthase catalyzes the final step of threonine biosynthesis. The conversion of O-phosphohomoserine into threonine and inorganic phosphate is pyridoxal 5'-phosphate dependent. The Thr-synth_1 CD includes members from higher plants, cyanobacteria; Region: Thr-synth_2; cd01560
656519003525	pyridoxal 5'-phosphate binding site [chemical binding]; other site
656519003526	catalytic residue [active]
656519003527	Domain of unknown function (DUF4118); Region: DUF4118; pfam13493
656519003528	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
656519003529	Ubiquitin-like proteins; Region: UBQ; cl00155
656519003530	Uncharacterized conserved protein [Function unknown]; Region: COG1656; cl09136
656519003531	Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826
656519003532	Helix-turn-helix domains; Region: HTH; cl00088
656519003533	Integrase core domain; Region: rve; cl01316
656519003534	Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471
656519003535	Anion permease ArsB/NhaD.  These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life.  A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl15357
656519003536	transmembrane helices; other site
656519003537	ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575
656519003538	N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357
656519003539	Firmicute fructose-1,6-bisphosphatase; Region: FBPase_2; pfam06874
656519003540	Transcriptional antiterminator [Transcription]; Region: BglG; COG3711
656519003541	Helix-turn-helix domains; Region: HTH; cl00088
656519003542	Helix-turn-helix domains; Region: HTH; cl00088
656519003543	PRD domain; Region: PRD; cl15445
656519003544	PRD domain; Region: PRD; cl15445
656519003545	PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568
656519003546	P-loop; other site
656519003547	active site
656519003548	phosphorylation site [posttranslational modification]
656519003549	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cl00163
656519003550	active site
656519003551	phosphorylation site [posttranslational modification]
656519003552	PTS system mannitol-specific transporter subunit IICBA; Provisional; Region: PRK15083
656519003553	Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; cl00557
656519003554	PTS_IIB_mannitol: subunit IIB of enzyme II (EII) of the mannitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a mannitol-specific permease with two cytoplasmic domains (IIA and IIB) and a transmembrane...; Region: PTS_IIB_mannitol; cd05567
656519003555	active site
656519003556	P-loop; other site
656519003557	phosphorylation site [posttranslational modification]
656519003558	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
656519003559	active site
656519003560	phosphorylation site [posttranslational modification]
656519003561	Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105
656519003562	1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164
656519003563	putative substrate binding site [chemical binding]; other site
656519003564	putative ATP binding site [chemical binding]; other site
656519003565	L-sorbose-1-phosphate reductase; Region: sorbose_phosphate_red; cd08238
656519003566	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
656519003567	putative NAD(P) binding site [chemical binding]; other site
656519003568	catalytic Zn binding site [ion binding]; other site
656519003569	Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367
656519003570	dimerization domain swap beta strand [polypeptide binding]; other site
656519003571	regulatory protein interface [polypeptide binding]; other site
656519003572	active site
656519003573	regulatory phosphorylation site [posttranslational modification]; other site
656519003574	Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833
656519003575	Protein of unknown function (DUF3159); Region: DUF3159; pfam11361
656519003576	Macro domain, Appr-1'-pase_like family. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ADP-ribose...; Region: Macro_Appr_pase_like; cd02908
656519003577	putative ADP-ribose binding site [chemical binding]; other site
656519003578	putative active site [active]
656519003579	Putative cyclase; Region: Cyclase; cl00814
656519003580	Protein of unknown function (DUF1385); Region: DUF1385; cl01595
656519003581	Protein of unknown function (DUF1385); Region: DUF1385; cl01595
656519003582	haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282
656519003583	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
656519003584	motif II; other site
656519003585	Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391
656519003586	D-glutamate deacylase; Validated; Region: PRK09061
656519003587	D-aminoacylases (N-acyl-D-Amino acid amidohydrolases) catalyze the hydrolysis of N-acyl-D-amino acids to produce the corresponding D-amino acids, which are used as intermediates in the synthesis of pesticides, bioactive peptides, and antibiotics; Region: D-aminoacylase; cd01297
656519003588	active site
656519003589	putative substrate binding pocket [chemical binding]; other site
656519003590	C4-dicarboxylate anaerobic carrier; Region: DcuC; cl15356
656519003591	Malic enzyme [Energy production and conversion]; Region: SfcA; COG0281
656519003592	Malic enzyme, N-terminal domain; Region: malic; pfam00390
656519003593	NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311
656519003594	putative NAD(P) binding site [chemical binding]; other site
656519003595	RelA- and SpoT-like ppGpp Synthetases and Hydrolases, catalytic domain; Region: Rel-Spo_like; cl11966
656519003596	metal binding triad [ion binding]; metal-binding site
656519003597	Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399
656519003598	synthetase active site [active]
656519003599	NTP binding site [chemical binding]; other site
656519003600	metal binding site [ion binding]; metal-binding site
656519003601	homoserine dehydrogenase; Provisional; Region: PRK06349
656519003602	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
656519003603	Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742
656519003604	ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881
656519003605	Leucine carboxyl methyltransferase; Region: LCM; cl01306
656519003606	Uncharacterized Fe-S protein [Energy production and conversion]; Region: COG1600
656519003607	SNARE associated Golgi protein; Region: SNARE_assoc; cl00429
656519003608	OpgC protein; Region: OpgC_C; cl00792
656519003609	Acyltransferase family; Region: Acyl_transf_3; pfam01757
656519003610	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
656519003611	active site residue [active]
656519003612	Highly conserved protein containing a thioredoxin domain [Posttranslational modification, protein turnover, chaperones]; Region: COG1331
656519003613	TRX domain, SSP411 protein family; members of this family are highly conserved proteins present in eukaryotes, bacteria and archaea, about 600-800 amino acids in length, which contain a TRX domain with a redox active CXXC motif. The human/rat protein; Region: SSP411; cd02955
656519003614	catalytic residues [active]
656519003615	MinD superfamily P-loop ATPase containing an inserted ferredoxin domain [Energy production and conversion]; Region: COG1149
656519003616	Ferredoxin [Energy production and conversion]; Region: COG1146
656519003617	4Fe-4S binding domain; Region: Fer4; cl02805
656519003618	Phosphorylase superfamily; Region: PNP_UDP_1; cl00303
656519003619	Citrate synthase (CS), citryl-CoA lyase (CCL), the C-terminal portion of the single-subunit type ATP-citrate lyase (ACL) and the C-terminal portion of the large subunit of the two-subunit type ACL. CS catalyzes the condensation of acetyl coenzyme A; Region: CS_ACL-C_CCL; cl00416
656519003620	Citrate synthase; Region: Citrate_synt; pfam00285
656519003621	oxalacetate binding site [chemical binding]; other site
656519003622	citrylCoA binding site [chemical binding]; other site
656519003623	coenzyme A binding site [chemical binding]; other site
656519003624	catalytic triad [active]
656519003625	short chain dehydrogenase; Validated; Region: PRK06182
656519003626	17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374
656519003627	NADP binding site [chemical binding]; other site
656519003628	active site
656519003629	steroid binding site; other site
656519003630	Peptidase C1B subfamily (MEROPS database nomenclature); composed of eukaryotic bleomycin hydrolases (BH) and bacterial aminopeptidases C (pepC). The proteins of this subfamily contain a large insert relative to the C1A peptidase (papain) subfamily. BH is...; Region: Peptidase_C1B; cd00585
656519003631	trimer interface [polypeptide binding]; other site
656519003632	active site
656519003633	G bulge; other site
656519003634	tRNA-binding-domain-containing CsaA-like proteins. CsaA is a molecular chaperone with export related activities. CsaA has a putative tRNA binding activity. The functional unit of CsaA is a homodimer and this domain acts as a dimerization domain; Region: tRNA_bind_CsaA; cd02798
656519003635	dimer interface [polypeptide binding]; other site
656519003636	putative tRNA-binding site [nucleotide binding]; other site
656519003637	ribonuclease BN/unknown domain fusion protein; Reviewed; Region: rbn; PRK04214
656519003638	Virulence factor BrkB; Region: Virul_fac_BrkB; cl07918
656519003639	pyruvate carboxylase; Reviewed; Region: PRK12999
656519003640	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
656519003641	ATP-grasp domain; Region: ATP-grasp_4; cl03087
656519003642	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; cl08365
656519003643	Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937
656519003644	active site
656519003645	catalytic residues [active]
656519003646	metal binding site [ion binding]; metal-binding site
656519003647	homodimer binding site [polypeptide binding]; other site
656519003648	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
656519003649	carboxyltransferase (CT) interaction site; other site
656519003650	biotinylation site [posttranslational modification]; other site
656519003651	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3296; cl15800
656519003652	Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840
656519003653	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
656519003654	active site
656519003655	metal binding site [ion binding]; metal-binding site
656519003656	DNA binding site [nucleotide binding]
656519003657	Uncharacterized conserved protein [Function unknown]; Region: COG4717
656519003658	V-type ATP synthase subunit I; Validated; Region: PRK05771
656519003659	AAA domain; Region: AAA_27; pfam13514
656519003660	DNA polymerase IV; Reviewed; Region: PRK03103
656519003661	umuC subunit of DNA Polymerase V; Region: PolY_Pol_V_umuC; cd01700
656519003662	active site
656519003663	DNA binding site [nucleotide binding]
656519003664	phosphoribosylpyrophosphate synthetase; Provisional; Region: PRK06827
656519003665	N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793
656519003666	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
656519003667	active site
656519003668	Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG2607
656519003669	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
656519003670	Walker A motif; other site
656519003671	ATP binding site [chemical binding]; other site
656519003672	Walker B motif; other site
656519003673	Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513
656519003674	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
656519003675	ATP binding site [chemical binding]; other site
656519003676	Mg++ binding site [ion binding]; other site
656519003677	motif III; other site
656519003678	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
656519003679	nucleotide binding region [chemical binding]; other site
656519003680	ATP-binding site [chemical binding]; other site
656519003681	DbpA RNA binding domain; Region: DbpA; pfam03880
656519003682	glutamate dehydrogenase; Provisional; Region: PRK09414
656519003683	Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812
656519003684	NAD(P) binding domain of glutamate dehydrogenase, subgroup 2; Region: NAD_bind_2_Glu_DH; cd05313
656519003685	NAD(P) binding site [chemical binding]; other site
656519003686	Diaminopimelate decarboxylase [Amino acid transport and metabolism]; Region: LysA; COG0019
656519003687	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828
656519003688	active site
656519003689	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
656519003690	substrate binding site [chemical binding]; other site
656519003691	catalytic residues [active]
656519003692	dimer interface [polypeptide binding]; other site
656519003693	Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950
656519003694	dihydrodipicolinate synthase; Region: dapA; TIGR00674
656519003695	dimer interface [polypeptide binding]; other site
656519003696	active site
656519003697	catalytic residue [active]
656519003698	dihydrodipicolinate reductase; Provisional; Region: PRK00048
656519003699	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
656519003700	Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173
656519003701	Tetrahydrodipicolinate succinyltransferase N-terminal; Region: DapH_N; pfam08503
656519003702	2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-acetyltransferase; Region: DapD_Ac; TIGR03532
656519003703	2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (also called THP succinyltransferase): THDP N-succinyltransferase catalyzes the conversion of tetrahydrodipicolinate and succinyl-CoA to N-succinyltetrahydrodipicolinate and CoA; Region: LbH_THP_succinylT; cd03350
656519003704	trimer interface [polypeptide binding]; other site
656519003705	active site
656519003706	substrate binding site [chemical binding]; other site
656519003707	CoA binding site [chemical binding]; other site
656519003708	acetylornithine aminotransferase; Provisional; Region: PRK02627
656519003709	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
656519003710	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
656519003711	catalytic residue [active]
656519003712	site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236
656519003713	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
656519003714	DNA binding site [nucleotide binding]
656519003715	Int/Topo IB signature motif; other site
656519003716	active site
656519003717	ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346
656519003718	Clp amino terminal domain; Region: Clp_N; pfam02861
656519003719	Clp amino terminal domain; Region: Clp_N; pfam02861
656519003720	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
656519003721	Walker A motif; other site
656519003722	ATP binding site [chemical binding]; other site
656519003723	Walker B motif; other site
656519003724	arginine finger; other site
656519003725	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
656519003726	Walker A motif; other site
656519003727	ATP binding site [chemical binding]; other site
656519003728	Walker B motif; other site
656519003729	arginine finger; other site
656519003730	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; cl11083
656519003731	Phospholipid methyltransferase; Region: PEMT; cl00763
656519003732	Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381
656519003733	Fic/DOC family; Region: Fic; cl00960
656519003734	Antidote-toxin recognition MazE; Region: Antitoxin-MazE; cl00877
656519003735	Fic/DOC family N-terminal; Region: Fic_N; pfam13784
656519003736	Fic/DOC family; Region: Fic; cl00960
656519003737	Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane]; Region: Cfa; COG2230
656519003738	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
656519003739	S-adenosylmethionine binding site [chemical binding]; other site
656519003740	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
656519003741	S-adenosylmethionine binding site [chemical binding]; other site
656519003742	atypical (a) SDRs, subgroup 5; Region: SDR_a5; cd05243
656519003743	NADH(P)-binding; Region: NAD_binding_10; pfam13460
656519003744	NAD(P) binding site [chemical binding]; other site
656519003745	putative active site [active]
656519003746	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
656519003747	Probable transposase; Region: OrfB_IS605; pfam01385
656519003748	transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766
656519003749	Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282
656519003750	Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209
656519003751	folate binding site [chemical binding]; other site
656519003752	NADP+ binding site [chemical binding]; other site
656519003753	NADPH-dependent FMN reductase; Region: FMN_red; cl00438
656519003754	Tryptophan synthase-beta:  Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446
656519003755	Pyridoxal-phosphate dependent enzyme; Region: PALP; pfam00291
656519003756	pyridoxal 5'-phosphate binding site [chemical binding]; other site
656519003757	catalytic residue [active]
656519003758	Transcriptional regulators [Transcription]; Region: PhnF; COG2188
656519003759	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
656519003760	DNA-binding site [nucleotide binding]; DNA binding site
656519003761	UTRA domain; Region: UTRA; cl01230
656519003762	Chromate transport protein ChrA [Inorganic ion transport and metabolism]; Region: ChrA; COG2059
656519003763	Chromate transporter; Region: Chromate_transp; pfam02417
656519003764	Helix-turn-helix domains; Region: HTH; cl00088
656519003765	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801
656519003766	HTH-like domain; Region: HTH_21; pfam13276
656519003767	Integrase core domain; Region: rve; cl01316
656519003768	Integrase core domain; Region: rve_3; cl15866
656519003769	Chromate transporter; Region: Chromate_transp; pfam02417
656519003770	Flavin Reductases; Region: FlaRed; cl00801
656519003771	Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961
656519003772	Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338
656519003773	catalytic residues [active]
656519003774	catalytic nucleophile [active]
656519003775	Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118
656519003776	putative peptidoglycan binding site; other site
656519003777	LexA repressor; Validated; Region: PRK00215
656519003778	Helix-turn-helix domains; Region: HTH; cl00088
656519003779	Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529
656519003780	Catalytic site [active]
656519003781	Family 4 Uracil-DNA glycosylase (UDG), found exclusively in thermophilic organisms; Region: UDG_F4_TTUDGA_like; cd10030
656519003782	Fe-S cluster binding site [ion binding]; other site
656519003783	active site
656519003784	The eukaryotic Sm and Sm-like (LSm) proteins associate with RNA to form the core domain of the ribonucleoprotein particles involved in a variety of RNA processing events including pre-mRNA splicing, telomere replication, and mRNA degradation.  Members of...; Region: Sm_like; cl00259
656519003785	Sm1 motif; other site
656519003786	D3 - B interaction site; other site
656519003787	D1 - D2 interaction site; other site
656519003788	Hfq - Hfq interaction site; other site
656519003789	RNA binding pocket [nucleotide binding]; other site
656519003790	Sm2 motif; other site
656519003791	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
656519003792	catalytic residues [active]
656519003793	tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324
656519003794	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
656519003795	DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095
656519003796	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
656519003797	ATP binding site [chemical binding]; other site
656519003798	Mg2+ binding site [ion binding]; other site
656519003799	G-X-G motif; other site
656519003800	MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is...; Region: MutL_Trans; cd00782
656519003801	ATP binding site [chemical binding]; other site
656519003802	MutL C terminal dimerisation domain; Region: MutL_C; cl07336
656519003803	DNA mismatch repair protein MutS; Provisional; Region: PRK05399
656519003804	MutS domain I; Region: MutS_I; pfam01624
656519003805	MutS domain II; Region: MutS_II; pfam05188
656519003806	MutS family domain IV; Region: MutS_IV; pfam05190
656519003807	MutS1 homolog in eukaryotes.  The MutS protein initiates DNA mismatch repair by recognizing mispaired and unpaired bases embedded in duplex DNA and activating endo- and exonucleases to remove the mismatch.  Members of the MutS family possess C-terminal...; Region: ABC_MutS1; cd03284
656519003808	Walker A/P-loop; other site
656519003809	ATP binding site [chemical binding]; other site
656519003810	Q-loop/lid; other site
656519003811	ABC transporter signature motif; other site
656519003812	Walker B; other site
656519003813	D-loop; other site
656519003814	H-loop/switch region; other site
656519003815	(dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14328
656519003816	Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919
656519003817	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
656519003818	FeS/SAM binding site; other site
656519003819	TRAM domain; Region: TRAM; cl01282
656519003820	K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569
656519003821	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
656519003822	Anion permease ArsB/NhaD.  These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life.  A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl15357
656519003823	potassium uptake protein, TrkH family; Region: 2a38; TIGR00933
656519003824	Cation transport protein; Region: TrkH; cl10514
656519003825	Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730
656519003826	Rubredoxin; Region: Rubredoxin; pfam00301
656519003827	iron binding site [ion binding]; other site
656519003828	CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cd00400
656519003829	Voltage gated chloride channel; Region: Voltage_CLC; pfam00654
656519003830	Cl- selectivity filter; other site
656519003831	Cl- binding residues [ion binding]; other site
656519003832	pore gating glutamate residue; other site
656519003833	dimer interface [polypeptide binding]; other site
656519003834	FOG: CBS domain [General function prediction only]; Region: COG0517
656519003835	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205
656519003836	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354
656519003837	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
656519003838	ATP binding site [chemical binding]; other site
656519003839	Mg2+ binding site [ion binding]; other site
656519003840	G-X-G motif; other site
656519003841	Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826
656519003842	Helix-turn-helix domains; Region: HTH; cl00088
656519003843	Integrase core domain; Region: rve; cl01316
656519003844	DNA gyrase subunit B; Validated; Region: gyrB; PRK05644
656519003845	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
656519003846	Mg2+ binding site [ion binding]; other site
656519003847	G-X-G motif; other site
656519003848	TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822
656519003849	anchoring element; other site
656519003850	dimer interface [polypeptide binding]; other site
656519003851	ATP binding site [chemical binding]; other site
656519003852	TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366
656519003853	active site
656519003854	putative metal-binding site [ion binding]; other site
656519003855	DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986
656519003856	DNA gyrase subunit A; Validated; Region: PRK05560
656519003857	DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes in DNA...; Region: TOP4c; cd00187
656519003858	CAP-like domain; other site
656519003859	active site
656519003860	primary dimer interface [polypeptide binding]; other site
656519003861	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
656519003862	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
656519003863	Cell Wall Hydrolase; Region: Hydrolase_2; pfam07486
656519003864	S-layer homology domain; Region: SLH; pfam00395
656519003865	DNA repair protein RecN; Region: recN; TIGR00634
656519003866	Domains similar to the eukaryotic reeler domain and bacterial cohesins; Region: Reeler_cohesin_like; cl14606
656519003867	Gram-negative bacterial tonB protein; Region: TonB; cl10048
656519003868	Biopolymer transport protein ExbD/TolR; Region: ExbD; cl00537
656519003869	MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568
656519003870	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
656519003871	dimerization interface [polypeptide binding]; other site
656519003872	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
656519003873	dimer interface [polypeptide binding]; other site
656519003874	phosphorylation site [posttranslational modification]
656519003875	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
656519003876	ATP binding site [chemical binding]; other site
656519003877	Mg2+ binding site [ion binding]; other site
656519003878	G-X-G motif; other site
656519003879	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
656519003880	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
656519003881	active site
656519003882	phosphorylation site [posttranslational modification]
656519003883	intermolecular recognition site; other site
656519003884	dimerization interface [polypeptide binding]; other site
656519003885	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
656519003886	DNA binding site [nucleotide binding]
656519003887	Stage V sporulation protein S (SpoVS); Region: SpoVS; cl01005
656519003888	Deinococcus radiodurans DR1281 and related proteins, metallophosphatase domain; Region: MPP_DR1281; cd07382
656519003889	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
656519003890	putative active site [active]
656519003891	metal binding site [ion binding]; metal-binding site
656519003892	homodimer binding site [polypeptide binding]; other site
656519003893	phosphodiesterase; Provisional; Region: PRK12704
656519003894	Protein gp23 (Bacteriophage A118); Region: Phage_Gp23; pfam10669
656519003895	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076
656519003896	RecX family; Region: RecX; cl00936
656519003897	recombinase A; Provisional; Region: recA; PRK09354
656519003898	RecA is a  bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response.  RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983
656519003899	hexamer interface [polypeptide binding]; other site
656519003900	Walker A motif; other site
656519003901	ATP binding site [chemical binding]; other site
656519003902	Walker B motif; other site
656519003903	2'-5' RNA ligase; Region: 2_5_ligase; TIGR02258
656519003904	LigT like Phosphoesterase; Region: LigT_PEase; pfam02834
656519003905	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
656519003906	binding surface
656519003907	TPR motif; other site
656519003908	TPR repeat; Region: TPR_11; pfam13414
656519003909	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
656519003910	binding surface
656519003911	TPR repeat; Region: TPR_11; pfam13414
656519003912	TPR motif; other site
656519003913	TPR repeat; Region: TPR_11; pfam13414
656519003914	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
656519003915	binding surface
656519003916	TPR motif; other site
656519003917	Tetratricopeptide repeat; Region: TPR_16; pfam13432
656519003918	competence damage-inducible protein A; Provisional; Region: PRK00549
656519003919	Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885
656519003920	putative MPT binding site; other site
656519003921	Competence-damaged protein; Region: CinA; cl00666
656519003922	Phosphatidylglycerophosphatase A; a bacterial membrane-associated enzyme involved in lipid metabolism; Region: PgpA; cd06971
656519003923	tetramer interfaces [polypeptide binding]; other site
656519003924	binuclear metal-binding site [ion binding]; other site
656519003925	CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453
656519003926	ribosomal protein S12 methylthiotransferase RimO; Region: TIGR01125
656519003927	Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919
656519003928	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
656519003929	FeS/SAM binding site; other site
656519003930	Predicted metal-binding protein (DUF2103); Region: DUF2103; cl01651
656519003931	Mismatch repair ATPase (MutS family) [DNA replication, recombination, and repair]; Region: MutS; COG0249
656519003932	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
656519003933	Walker A/P-loop; other site
656519003934	ATP binding site [chemical binding]; other site
656519003935	Q-loop/lid; other site
656519003936	ABC transporter signature motif; other site
656519003937	Walker B; other site
656519003938	D-loop; other site
656519003939	H-loop/switch region; other site
656519003940	Mismatch repair ATPase (MutS family) [DNA replication, recombination, and repair]; Region: MutS; COG0249
656519003941	The MutS protein initiates DNA mismatch repair by recognizing mispaired and unpaired bases embedded in duplex DNA and activating endo- and exonucleases to remove the mismatch.  Members of the MutS family also possess a conserved ATPase activity that...; Region: ABC_MutS_homologs; cd03243
656519003942	Walker A/P-loop; other site
656519003943	ATP binding site [chemical binding]; other site
656519003944	Q-loop/lid; other site
656519003945	ABC transporter signature motif; other site
656519003946	Walker B; other site
656519003947	D-loop; other site
656519003948	H-loop/switch region; other site
656519003949	mercuric reductase; Validated; Region: PRK06370
656519003950	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
656519003951	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
656519003952	L-lactate dehydrogenase; Reviewed; Region: ldh; PRK00066
656519003953	A subgroup of L-lactate dehydrogenases; Region: LDH_2; cd05292
656519003954	NAD binding site [chemical binding]; other site
656519003955	dimer interface [polypeptide binding]; other site
656519003956	substrate binding site [chemical binding]; other site
656519003957	tetramer (dimer of dimers) interface [polypeptide binding]; other site
656519003958	Uncharacterized conserved protein [Function unknown]; Region: COG2006
656519003959	Domain of unknown function (DUF362); Region: DUF362; pfam04015
656519003960	Methyltransferase domain; Region: Methyltransf_31; pfam13847
656519003961	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
656519003962	Survival protein SurE; Region: SurE; cl00448
656519003963	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761
656519003964	Domain of unknown function (DUF4115); Region: DUF4115; pfam13464
656519003965	Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580
656519003966	TM-ABC transporter signature motif; other site
656519003967	Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580
656519003968	Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580
656519003969	TM-ABC transporter signature motif; other site
656519003970	ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845
656519003971	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
656519003972	Walker A/P-loop; other site
656519003973	ATP binding site [chemical binding]; other site
656519003974	Q-loop/lid; other site
656519003975	ABC transporter signature motif; other site
656519003976	Walker B; other site
656519003977	D-loop; other site
656519003978	H-loop/switch region; other site
656519003979	This family represents domain II of the carbohydrate uptake proteins that transport only monosaccharides (Monos).  The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and hexoses; Region: ABC_Carb_Monos_II; cd03215
656519003980	Periplasmic binding domain of basic membrane lipoprotein, PnrA, in Treponema pallidum and its homologs from other bacteria and Archaea; Region: PBP1_BmpA_PnrA_like; cd06354
656519003981	ligand binding site [chemical binding]; other site
656519003982	Domain of unknown function (DUF4117); Region: DUF4117; pfam13491
656519003983	DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674
656519003984	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
656519003985	Ftsk gamma domain; Region: Ftsk_gamma; cl09645
656519003986	mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595
656519003987	Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446
656519003988	RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521
656519003989	aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874
656519003990	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
656519003991	NAD(P) binding site [chemical binding]; other site
656519003992	Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; cl15856
656519003993	Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950
656519003994	EamA-like transporter family; Region: EamA; cl01037
656519003995	EamA-like transporter family; Region: EamA; cl01037
656519003996	Predicted N6-adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0116
656519003997	THUMP domain; Region: THUMP; cl12076
656519003998	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
656519003999	Nicotinamidase/pyrazinamidase (PZase). Nicotinamidase, a ubiquitous enzyme in prokaryotes, converts nicotinamide to nicotinic acid (niacin) and ammonia, which in turn can be recycled to make nicotinamide adenine dinucleotide (NAD). The same enzyme is...; Region: nicotinamidase; cd01011
656519004000	Isochorismatase family; Region: Isochorismatase; pfam00857
656519004001	catalytic triad [active]
656519004002	metal binding site [ion binding]; metal-binding site
656519004003	conserved cis-peptide bond; other site
656519004004	Acylphosphatase; Region: Acylphosphatase; cl00551
656519004005	Glutaredoxin (GRX) family, GRX bacterial class 1 and 3 (b_1_3)-like subfamily; composed of bacterial GRXs, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, catalyzing the...; Region: GRX_GRXb_1_3_like; cd03418
656519004006	GSH binding site [chemical binding]; other site
656519004007	catalytic residues [active]
656519004008	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
656519004009	alkyl hydroperoxide reductase subunit F; Provisional; Region: PRK15317
656519004010	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
656519004011	Protein of unknown function (DUF964); Region: DUF964; cl01483
656519004012	flavoprotein, HI0933 family; Region: TIGR00275
656519004013	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
656519004014	Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities [Amino acid transport and metabolism]; Region: MalY; COG1168
656519004015	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
656519004016	pyridoxal 5'-phosphate binding site [chemical binding]; other site
656519004017	homodimer interface [polypeptide binding]; other site
656519004018	catalytic residue [active]
656519004019	dipeptidase PepV; Reviewed; Region: PRK07318
656519004020	M20 Peptidase Xaa-His dipeptidase (PepV) degrades hydrophobic dipeptides; Region: M20_PepV; cd03888
656519004021	active site
656519004022	metal binding site [ion binding]; metal-binding site
656519004023	Esterase/lipase [General function prediction only]; Region: COG1647
656519004024	oligoendopeptidase F; Region: pepF; TIGR00181
656519004025	Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_3; cd09608
656519004026	active site
656519004027	Zn binding site [ion binding]; other site
656519004028	6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870
656519004029	methylated-DNA--protein-cysteine methyltransferase; Provisional; Region: PRK00901
656519004030	The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445
656519004031	DNA binding site [nucleotide binding]
656519004032	active site
656519004033	asparaginyl-tRNA synthetase; Validated; Region: asnC; PRK03932
656519004034	EcAsnRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli asparaginyl-tRNA synthetase (AsnRS) and, in Arabidopsis thaliana and Saccharomyces cerevisiae mitochondrial (mt) AsnRS. This domain is a beta-barrel domain (OB...; Region: EcAsnRS_like_N; cd04318
656519004035	putative dimer interface [polypeptide binding]; other site
656519004036	putative anticodon binding site; other site
656519004037	Asx tRNA synthetase (AspRS/AsnRS) class II core domain.  Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776
656519004038	homodimer interface [polypeptide binding]; other site
656519004039	motif 1; other site
656519004040	motif 2; other site
656519004041	active site
656519004042	motif 3; other site
656519004043	Desulforedoxin (DSRD) domain; a small non-heme iron domain present in the desulforedoxin (rubredoxin oxidoreductase) and desulfoferrodoxin proteins of some archeael and bacterial methanogens and sulfate/sulfur reducers. Desulforedoxin is a small; Region: DSRD; cd00974
656519004044	non-heme iron binding site [ion binding]; other site
656519004045	dimer interface [polypeptide binding]; other site
656519004046	aspartate kinase; Reviewed; Region: PRK06635
656519004047	AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261
656519004048	putative nucleotide binding site [chemical binding]; other site
656519004049	putative catalytic residues [active]
656519004050	putative Mg ion binding site [ion binding]; other site
656519004051	putative aspartate binding site [chemical binding]; other site
656519004052	ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913
656519004053	putative allosteric regulatory site; other site
656519004054	ACT domains of the lysine-sensitive, aspartokinase (AK) isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AKii-LysC-BS-like_2; cd04936
656519004055	putative allosteric regulatory residue; other site
656519004056	homoserine dehydrogenase; Provisional; Region: PRK06349
656519004057	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
656519004058	Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742
656519004059	homoserine kinase; Provisional; Region: PRK01212
656519004060	GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544
656519004061	Predicted translation initiation factor 2B subunit, eIF-2B alpha/beta/delta family [Translation, ribosomal structure and biogenesis]; Region: COG0182; cl00348
656519004062	methylthioribose-1-phosphate isomerase; Reviewed; Region: mtnA; PRK05720
656519004063	Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557
656519004064	trimer interface [polypeptide binding]; other site
656519004065	active site
656519004066	cell division suppressor protein YneA; Provisional; Region: PRK14125
656519004067	Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118
656519004068	putative peptidoglycan binding site; other site
656519004069	FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388
656519004070	Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118
656519004071	putative peptidoglycan binding site; other site
656519004072	Cell Wall Hydrolase; Region: Hydrolase_2; pfam07486
656519004073	Mpr1p, Pad1p N-terminal (MPN) domains; Region: MPN; cl13996
656519004074	bifunctional ATP-dependent DNA helicase/DNA polymerase III subunit epsilon; Validated; Region: PRK08074
656519004075	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
656519004076	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
656519004077	endonuclease IV; Provisional; Region: PRK01060
656519004078	AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019
656519004079	AP (apurinic/apyrimidinic) site pocket; other site
656519004080	DNA interaction; other site
656519004081	Metal-binding active site; metal-binding site
656519004082	polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824
656519004083	Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363
656519004084	RNase E interface [polypeptide binding]; other site
656519004085	trimer interface [polypeptide binding]; other site
656519004086	Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726
656519004087	Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364
656519004088	RNase E interface [polypeptide binding]; other site
656519004089	trimer interface [polypeptide binding]; other site
656519004090	active site
656519004091	Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393
656519004092	putative nucleic acid binding region [nucleotide binding]; other site
656519004093	G-X-X-G motif; other site
656519004094	S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase  is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472
656519004095	RNA binding site [nucleotide binding]; other site
656519004096	domain interface; other site
656519004097	Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353
656519004098	16S/18S rRNA binding site [nucleotide binding]; other site
656519004099	S13e-L30e interaction site [polypeptide binding]; other site
656519004100	25S rRNA binding site [nucleotide binding]; other site
656519004101	bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627
656519004102	FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064
656519004103	active site
656519004104	Riboflavin kinase; Region: Flavokinase; cl03312
656519004105	tRNA pseudouridine synthase B; Provisional; Region: truB; PRK00130
656519004106	PseudoU_synth_EcTruB: Pseudouridine synthase, Escherichia coli TruB like. This group consists of bacterial pseudouridine synthases similar to E. coli TruB and Mycobacterium tuberculosis TruB. Pseudouridine synthases catalyze the isomerization of specific...; Region: PseudoU_synth_EcTruB; cd02573
656519004107	RNA binding site [nucleotide binding]; other site
656519004108	active site
656519004109	Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618
656519004110	DHH family; Region: DHH; pfam01368
656519004111	DHHA1 domain; Region: DHHA1; pfam02272
656519004112	Ribosome-binding factor A; Region: RBFA; cl00542
656519004113	Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760
656519004114	translation initiation factor IF-2; Region: IF-2; TIGR00487
656519004115	Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760
656519004116	Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887
656519004117	G1 box; other site
656519004118	putative GEF interaction site [polypeptide binding]; other site
656519004119	GTP/Mg2+ binding site [chemical binding]; other site
656519004120	Switch I region; other site
656519004121	G2 box; other site
656519004122	G3 box; other site
656519004123	Switch II region; other site
656519004124	G4 box; other site
656519004125	G5 box; other site
656519004126	This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702
656519004127	Translation-initiation factor 2; Region: IF-2; pfam11987
656519004128	mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692
656519004129	Ylxr homologs; group of conserved hypothetical bacterial proteins of unknown function; structure revealed putative RNA binding cleft; proteins are encoded by an operon that includes other proteins involved in transcription and/or translation; Region: YlxR; cd00279
656519004130	putative RNA binding cleft [nucleotide binding]; other site
656519004131	transcription elongation factor NusA; Provisional; Region: nusA; PRK12327
656519004132	NusA N-terminal domain; Region: NusA_N; pfam08529
656519004133	S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455
656519004134	RNA binding site [nucleotide binding]; other site
656519004135	homodimer interface [polypeptide binding]; other site
656519004136	K homology RNA-binding domain, type I.  KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains that...; Region: KH-I; cl00098
656519004137	NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134
656519004138	G-X-X-G motif; other site
656519004139	ribosome maturation protein RimP; Reviewed; Region: PRK00092
656519004140	The eukaryotic Sm and Sm-like (LSm) proteins associate with RNA to form the core domain of the ribonucleoprotein particles involved in a variety of RNA processing events including pre-mRNA splicing, telomere replication, and mRNA degradation.  Members of...; Region: Sm_like; cl00259
656519004141	YxlS is a Bacillus subtilis gene of unknown function with two domains that each have an alpha/beta fold.  The N-terminal domain is composed of two alpha-helices and a three-stranded beta-sheet, while the C-terminal domain is composed of one alpha-helix...; Region: YlxS_C; cd01734
656519004142	Sm1 motif; other site
656519004143	predicted subunit interaction site [polypeptide binding]; other site
656519004144	RNA binding pocket [nucleotide binding]; other site
656519004145	Sm2 motif; other site
656519004146	DNA polymerase III PolC; Validated; Region: polC; PRK00448
656519004147	polC_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold nucleic acid binding domain of Bacillus subtilis type C replicative DNA polymerase III alpha subunit (polC). Replication in B. subtilis and Staphylococcus aureus requires two...; Region: polC_OBF; cd04484
656519004148	generic binding surface II; other site
656519004149	generic binding surface I; other site
656519004150	DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127
656519004151	active site
656519004152	substrate binding site [chemical binding]; other site
656519004153	catalytic site [active]
656519004154	Bacterial DNA polymerase III alpha subunit; Region: DNA_pol3_alpha; pfam07733
656519004155	prolyl-tRNA synthetase; Provisional; Region: PRK09194
656519004156	Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent formation of...; Region: ProRS_core_prok; cd00779
656519004157	dimer interface [polypeptide binding]; other site
656519004158	motif 1; other site
656519004159	active site
656519004160	motif 2; other site
656519004161	INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334
656519004162	putative deacylase active site [active]
656519004163	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it attaches...; Region: class_II_aaRS-like_core; cl00268
656519004164	active site
656519004165	motif 3; other site
656519004166	ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861
656519004167	anticodon binding site; other site
656519004168	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366
656519004169	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694
656519004170	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694
656519004171	Predicted membrane-associated Zn-dependent proteases 1 [Cell envelope biogenesis, outer membrane]; Region: COG0750
656519004172	RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163
656519004173	active site
656519004174	PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989
656519004175	protein binding site [polypeptide binding]; other site
656519004176	Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020
656519004177	putative substrate binding region [chemical binding]; other site
656519004178	pheromone autoinducer 2 transporter; Reviewed; Region: tqsA; cl00465
656519004179	Domain of unknown function DUF20; Region: UPF0118; pfam01594
656519004180	Cytidylyltransferase family; Region: CTP_transf_1; cl00347
656519004181	Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cl00230
656519004182	Putative undecaprenyl diphosphate synthase; Region: Prenyltransf; pfam01255
656519004183	catalytic residue [active]
656519004184	putative FPP diphosphate  binding site; other site
656519004185	putative FPP binding hydrophobic cleft; other site
656519004186	dimer interface [polypeptide binding]; other site
656519004187	putative IPP diphosphate binding site; other site
656519004188	ribosome recycling factor; Reviewed; Region: frr; PRK00083
656519004189	Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation.  Thus ribosomes are 'recycled' and ready for another round of...; Region: RRF; cd00520
656519004190	hinge region; other site
656519004191	UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254
656519004192	putative nucleotide binding site [chemical binding]; other site
656519004193	uridine monophosphate binding site [chemical binding]; other site
656519004194	homohexameric interface [polypeptide binding]; other site
656519004195	elongation factor Ts; Provisional; Region: tsf; PRK09377
656519004196	Ubiquitin Associated domain. The UBA domain is a commonly occurring sequence motif in some members of the ubiquitination pathway, UV excision repair proteins, and certain protein kinases. Although its specific role is so far unknown, it has been...; Region: UBA; cl00153
656519004197	Elongation factor TS; Region: EF_TS; pfam00889
656519004198	Elongation factor TS; Region: EF_TS; pfam00889
656519004199	Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425
656519004200	rRNA interaction site [nucleotide binding]; other site
656519004201	S8 interaction site; other site
656519004202	putative laminin-1 binding site; other site
656519004203	transcriptional repressor CodY; Validated; Region: PRK04158
656519004204	CodY GAF-like domain; Region: CodY; pfam06018
656519004205	Helix-turn-helix domains; Region: HTH; cl00088
656519004206	ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201
656519004207	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
656519004208	Walker A motif; other site
656519004209	ATP binding site [chemical binding]; other site
656519004210	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
656519004211	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; cl11083
656519004212	Protease HslV and the ATPase/chaperone HslU are part of an ATP-dependent proteolytic system that is the prokaryotic homolog of the proteasome. HslV is a dimer of hexamers (a dodecamer) that forms a central proteolytic chamber with active sites on the...; Region: protease_HslV; cd01913
656519004213	active site
656519004214	HslU subunit interaction site [polypeptide binding]; other site
656519004215	DNA topoisomerase I; Validated; Region: PRK05582
656519004216	TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I.   Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363
656519004217	active site
656519004218	interdomain interaction site; other site
656519004219	putative metal-binding site [ion binding]; other site
656519004220	nucleotide binding site [chemical binding]; other site
656519004221	DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186
656519004222	domain I; other site
656519004223	DNA binding groove [nucleotide binding]
656519004224	phosphate binding site [ion binding]; other site
656519004225	domain II; other site
656519004226	domain III; other site
656519004227	nucleotide binding site [chemical binding]; other site
656519004228	catalytic site [active]
656519004229	domain IV; other site
656519004230	Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396
656519004231	Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396
656519004232	Ogr/Delta-like zinc finger; Region: Ogr_Delta; pfam04606
656519004233	Protein of unknown function (DUF494); Region: DUF494; cl01103
656519004234	Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695
656519004235	DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481
656519004236	Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168
656519004237	Cation transport protein; Region: TrkH; cl10514
656519004238	potassium transporter peripheral membrane component; Reviewed; Region: trkA; PRK09496
656519004239	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
656519004240	Protein of unknown function (DUF541); Region: SIMPL; cl01077
656519004241	Biopolymer transport protein ExbD/TolR; Region: ExbD; cl00537
656519004242	MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568
656519004243	Gram-negative bacterial tonB protein; Region: TonB; cl10048
656519004244	Outer membrane cobalamin receptor protein [Coenzyme metabolism]; Region: BtuB; COG4206
656519004245	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
656519004246	N-terminal plug; other site
656519004247	ligand-binding site [chemical binding]; other site
656519004248	Restriction endonuclease; Region: Mrr_cat; cl00516
656519004249	Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606
656519004250	Subunit ChlI of Mg-chelatase; Region: ChlI; cl12214
656519004251	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
656519004252	Walker A motif; other site
656519004253	ATP binding site [chemical binding]; other site
656519004254	Walker B motif; other site
656519004255	arginine finger; other site
656519004256	Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335
656519004257	QueT transporter; Region: QueT; cl01932
656519004258	bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182
656519004259	RNA/DNA hybrid binding site [nucleotide binding]; other site
656519004260	active site
656519004261	GTPase YlqF; Reviewed; Region: rbgA; PRK09563
656519004262	Circularly permuted YlqF GTPase; Region: YlqF; cd01856
656519004263	GTP/Mg2+ binding site [chemical binding]; other site
656519004264	G4 box; other site
656519004265	G5 box; other site
656519004266	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
656519004267	G1 box; other site
656519004268	G1 box; other site
656519004269	GTP/Mg2+ binding site [chemical binding]; other site
656519004270	Switch I region; other site
656519004271	G2 box; other site
656519004272	G2 box; other site
656519004273	Switch I region; other site
656519004274	G3 box; other site
656519004275	G3 box; other site
656519004276	Switch II region; other site
656519004277	Switch II region; other site
656519004278	Ribosomal protein L19; Region: Ribosomal_L19; cl00406
656519004279	SpoU rRNA Methylase family; Region: SpoU_methylase; cl00362
656519004280	tRNA (Guanine-1)-methyltransferase; Region: tRNA_m1G_MT; cl00407
656519004281	16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122
656519004282	RimM N-terminal domain; Region: RimM; pfam01782
656519004283	Photosynthetic reaction center (RC) complex, subunit H;  RC is an integral membrane protein-pigment complex which catalyzes light-induced reduction of ubiquinone to ubiquinol, generating a transmembrane electrochemical gradient of protons used to produce...; Region: PRCH; cl09959
656519004284	Predicted RNA-binding protein (contains KH domain) [General function prediction only]; Region: COG1837
656519004285	K homology RNA-binding domain, type I.  KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains that...; Region: KH-I; cl00098
656519004286	Ribosomal protein S16; Region: Ribosomal_S16; cl00368
656519004287	signal recognition particle protein; Provisional; Region: PRK10867
656519004288	SRP54-type protein, helical bundle domain; Region: SRP54_N; cl03758
656519004289	The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115
656519004290	P loop; other site
656519004291	GTP binding site [chemical binding]; other site
656519004292	Signal peptide binding domain; Region: SRP_SPB; pfam02978
656519004293	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761
656519004294	signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416
656519004295	SRP54-type protein, helical bundle domain; Region: SRP54_N; cl03758
656519004296	The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115
656519004297	P loop; other site
656519004298	GTP binding site [chemical binding]; other site
656519004299	chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168
656519004300	Barmotin is a tight junction-associated protein expressed in rat epithelial cells which is thought to have an important regulatory role in tight junction barrier function.  Barmotin belongs to the SMC protein family. SMC proteins are large; Region: ABC_SMC_barmotin; cd03278
656519004301	Walker A/P-loop; other site
656519004302	ATP binding site [chemical binding]; other site
656519004303	Q-loop/lid; other site
656519004304	SMC proteins Flexible Hinge Domain; Region: SMC_hinge; cl05797
656519004305	chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168
656519004306	Barmotin is a tight junction-associated protein expressed in rat epithelial cells which is thought to have an important regulatory role in tight junction barrier function.  Barmotin belongs to the SMC protein family. SMC proteins are large; Region: ABC_SMC_barmotin; cd03278
656519004307	Walker B; other site
656519004308	D-loop; other site
656519004309	H-loop/switch region; other site
656519004310	Stage V sporulation protein S (SpoVS); Region: SpoVS; cl01005
656519004311	16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187
656519004312	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
656519004313	RNA binding surface [nucleotide binding]; other site
656519004314	Pseudouridine synthases  are responsible for the synthesis of pseudouridine from uracil in ribosomal RNA. The RsuA subfamily includes Pseudouridine Synthase similar to Ribosomal small subunit pseudouridine 516 synthase. Most of the proteins in this...; Region: PseudoU_synth_RsuA_like; cd02870
656519004315	active site
656519004316	Putative transcriptional regulators (Ypuh-like); Region: DUF387; cl00612
656519004317	ScpA/B protein; Region: ScpA_ScpB; cl00598
656519004318	Uncharacterized homologs of Site-2 protease (S2P), zinc metalloproteases (MEROPS family M50) which cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of the...; Region: S2P-M50_like_1; cd06158
656519004319	putative substrate binding region [chemical binding]; other site
656519004320	tRNA nucleotidyltransferase/poly(A) polymerase [Translation, ribosomal structure and biogenesis]; Region: PcnB; COG0617
656519004321	Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398
656519004322	active site
656519004323	NTP binding site [chemical binding]; other site
656519004324	metal binding triad [ion binding]; metal-binding site
656519004325	nicotinate phosphoribosyltransferase; Provisional; Region: PRK07188
656519004326	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl09108
656519004327	active site
656519004328	pyrimidine-nucleoside phosphorylase; Reviewed; Region: PRK06078
656519004329	Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885
656519004330	Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591
656519004331	Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; cl06734
656519004332	Phosphorylase superfamily; Region: PNP_UDP_1; cl00303
656519004333	Thermophilic metalloprotease (M29); Region: Peptidase_M29; pfam02073
656519004334	PHP family phosphoesterase with a Zn ribbon [General function prediction only]; Region: COG1379
656519004335	PHP-associated; Region: PHP_C; pfam13263
656519004336	ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424
656519004337	dimer interface [polypeptide binding]; other site
656519004338	ADP-ribose binding site [chemical binding]; other site
656519004339	active site
656519004340	nudix motif; other site
656519004341	metal binding site [ion binding]; metal-binding site
656519004342	sporulation transcription factor Spo0A; Region: spore_0_A; TIGR02875
656519004343	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
656519004344	active site
656519004345	phosphorylation site [posttranslational modification]
656519004346	intermolecular recognition site; other site
656519004347	dimerization interface [polypeptide binding]; other site
656519004348	Sporulation initiation factor Spo0A C terminal; Region: Spo0A_C; pfam08769
656519004349	ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497
656519004350	RecN ATPase involved in DNA repair; ABC (ATP-binding cassette) transporter nucleotide-binding domain; ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds including sugars, ions, peptides, and...; Region: ABC_RecN; cd03241
656519004351	Walker A/P-loop; other site
656519004352	ATP binding site [chemical binding]; other site
656519004353	Q-loop/lid; other site
656519004354	RecN ATPase involved in DNA repair; ABC (ATP-binding cassette) transporter nucleotide-binding domain; ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds including sugars, ions, peptides, and...; Region: ABC_RecN; cd03241
656519004355	ABC transporter signature motif; other site
656519004356	Walker B; other site
656519004357	D-loop; other site
656519004358	H-loop/switch region; other site
656519004359	inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK03708
656519004360	Diacylglycerol kinase catalytic domain; Region: DAGK_cat; cl01255
656519004361	Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189
656519004362	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
656519004363	RNA binding surface [nucleotide binding]; other site
656519004364	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl15754
656519004365	1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444
656519004366	Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007
656519004367	TPP-binding site; other site
656519004368	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
656519004369	PYR/PP interface [polypeptide binding]; other site
656519004370	dimer interface [polypeptide binding]; other site
656519004371	TPP binding site [chemical binding]; other site
656519004372	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
656519004373	Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142
656519004374	Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685
656519004375	substrate binding pocket [chemical binding]; other site
656519004376	chain length determination region; other site
656519004377	substrate-Mg2+ binding site; other site
656519004378	catalytic residues [active]
656519004379	aspartate-rich region 1; other site
656519004380	active site lid residues [active]
656519004381	aspartate-rich region 2; other site
656519004382	Exonuclease VII small subunit; Region: Exonuc_VII_S; cl00750
656519004383	exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286
656519004384	ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489
656519004385	generic binding surface II; other site
656519004386	generic binding surface I; other site
656519004387	putative oxidoreductase; Provisional; Region: PRK12831
656519004388	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
656519004389	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
656519004390	ferredoxin-NADP(+) reductase subunit alpha; Reviewed; Region: PRK06222
656519004391	FAD/NAD binding domain in the electron transfer subunit of dihydroorotate dehydrogenase-like proteins. Dihydroorotate dehydrogenases (DHODs) catalyze the only redox reaction in pyrimidine de novo biosynthesis. They catalyze the oxidation of (S)...; Region: DHOD_e_trans_like1; cd06219
656519004392	FAD binding pocket [chemical binding]; other site
656519004393	FAD binding motif [chemical binding]; other site
656519004394	phosphate binding motif [ion binding]; other site
656519004395	beta-alpha-beta structure motif; other site
656519004396	NAD binding pocket [chemical binding]; other site
656519004397	Iron coordination center [ion binding]; other site
656519004398	aspartate aminotransferase; Provisional; Region: PRK05764
656519004399	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
656519004400	pyridoxal 5'-phosphate binding site [chemical binding]; other site
656519004401	homodimer interface [polypeptide binding]; other site
656519004402	catalytic residue [active]
656519004403	RNA binding domain of NusB (N protein-Utilization Substance B) and Sun (also known as RrmB or Fmu) proteins. This family includes two orthologous groups exemplified by the transcription termination factor NusB and the N-terminal domain of the...; Region: NusB_Sun; cl00223
656519004404	putative RNA binding site [nucleotide binding]; other site
656519004405	Asp23 family; Region: Asp23; cl00574
656519004406	Asp23 family; Region: Asp23; cl00574
656519004407	NAD(P)H-nitrite reductase [Energy production and conversion]; Region: NirB; COG1251
656519004408	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
656519004409	elongation factor P; Validated; Region: PRK00529
656519004410	Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207
656519004411	S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470
656519004412	RNA binding site [nucleotide binding]; other site
656519004413	S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794
656519004414	RNA binding site [nucleotide binding]; other site
656519004415	Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006
656519004416	Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321
656519004417	Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092
656519004418	active site
656519004419	Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466
656519004420	trimer interface [polypeptide binding]; other site
656519004421	active site
656519004422	dimer interface [polypeptide binding]; other site
656519004423	Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464
656519004424	bifunctional shikimate kinase/3-dehydroquinate synthase; Provisional; Region: PRK14021
656519004425	ADP binding site [chemical binding]; other site
656519004426	magnesium binding site [ion binding]; other site
656519004427	putative shikimate binding site; other site
656519004428	Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195
656519004429	active site
656519004430	dimer interface [polypeptide binding]; other site
656519004431	metal binding site [ion binding]; metal-binding site
656519004432	O-Antigen ligase; Region: Wzy_C; cl04850
656519004433	type IV pilus secretin (or competence protein) PilQ; Region: IV_pilus_PilQ; TIGR02515
656519004434	Bacterial type II and III secretion system protein; Region: Secretin; pfam00263
656519004435	Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; cl06830
656519004436	Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; cl06830
656519004437	Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; cl06830
656519004438	Tfp pilus assembly protein FimT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimT; COG4970
656519004439	Type II secretion system (T2SS), protein G; Region: T2SG; pfam08334
656519004440	Type II secretion system (T2SS), protein F; Region: T2SF; cl00906
656519004441	Type II secretion system (T2SS), protein F; Region: T2SF; cl00906
656519004442	Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157
656519004443	Type II secretory pathway, ATPase PulE/Tfp pilus assembly pathway, ATPase PilB [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulE; COG2804
656519004444	PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129
656519004445	Walker A motif; other site
656519004446	ATP binding site [chemical binding]; other site
656519004447	Walker B motif; other site
656519004448	putative alpha-isopropylmalate/homocitrate synthase family transferase; Provisional; Region: PRK12344
656519004449	Desulfobacterium autotrophicum LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA3; cd07941
656519004450	active site
656519004451	catalytic residues [active]
656519004452	metal binding site [ion binding]; metal-binding site
656519004453	LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; cl07212
656519004454	tartrate dehydrogenase; Provisional; Region: PRK08194
656519004455	Isocitrate/isopropylmalate dehydrogenase; Region: Iso_dh; cl00445
656519004456	Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577
656519004457	substrate binding site [chemical binding]; other site
656519004458	3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402
656519004459	3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583
656519004460	substrate binding site [chemical binding]; other site
656519004461	ligand binding site [chemical binding]; other site
656519004462	2-isopropylmalate synthase; Validated; Region: PRK00915
656519004463	2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940
656519004464	active site
656519004465	catalytic residues [active]
656519004466	metal binding site [ion binding]; metal-binding site
656519004467	LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; cl07212
656519004468	ketol-acid reductoisomerase; Provisional; Region: PRK05479
656519004469	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
656519004470	Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450
656519004471	acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895
656519004472	N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878
656519004473	putative valine binding site [chemical binding]; other site
656519004474	dimer interface [polypeptide binding]; other site
656519004475	Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369
656519004476	acetolactate synthase 3 catalytic subunit; Reviewed; Region: PRK06048
656519004477	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
656519004478	PYR/PP interface [polypeptide binding]; other site
656519004479	dimer interface [polypeptide binding]; other site
656519004480	TPP binding site [chemical binding]; other site
656519004481	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; cl00815
656519004482	Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015
656519004483	TPP-binding site [chemical binding]; other site
656519004484	dimer interface [polypeptide binding]; other site
656519004485	Dehydratase family; Region: ILVD_EDD; cl00340
656519004486	D-Alanine aminotransferase (D-AAT_like): D-amino acid aminotransferase catalyzes transamination between D-amino acids and their respective alpha-keto acids. It plays a major role in the synthesis of bacterial cell wall components like D-alanine and...; Region: D-AAT_like; cd01558
656519004487	homodimer interface [polypeptide binding]; other site
656519004488	substrate-cofactor binding pocket; other site
656519004489	pyridoxal 5'-phosphate binding site [chemical binding]; other site
656519004490	catalytic residue [active]
656519004491	Transposase domain (DUF772); Region: DUF772; cl15789
656519004492	ATP-dependent transcriptional regulator [Transcription]; Region: MalT; COG2909
656519004493	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
656519004494	DNA binding residues [nucleotide binding]
656519004495	dimerization interface [polypeptide binding]; other site
656519004496	type IV pilus secretin (or competence protein) PilQ; Region: IV_pilus_PilQ; TIGR02515
656519004497	Secretin and TonB N terminus short domain; Region: STN; cl06624
656519004498	Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958
656519004499	pilus (MSHA type) biogenesis protein MshL; Region: pilus_MshL; TIGR02519
656519004500	Bacterial type II and III secretion system protein; Region: Secretin; pfam00263
656519004501	Pilus assembly protein, PilO; Region: PilO; cl01234
656519004502	Tfp pilus assembly protein PilN [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilN; COG3166
656519004503	Fimbrial assembly protein (PilN); Region: PilN; pfam05137
656519004504	Cell division protein FtsA; Region: FtsA; cl11496
656519004505	Competence protein A; Region: Competence_A; pfam11104
656519004506	Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989
656519004507	Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750
656519004508	Type IV leader peptidase family; Region: Peptidase_A24; cl02077
656519004509	general secretion pathway protein F; Region: GspF; TIGR02120
656519004510	Type II secretion system (T2SS), protein F; Region: T2SF; cl00906
656519004511	Type II secretion system (T2SS), protein F; Region: T2SF; cl00906
656519004512	pilus retraction protein PilT; Region: pilT_fam; TIGR01420
656519004513	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
656519004514	Walker A motif; other site
656519004515	ATP binding site [chemical binding]; other site
656519004516	Walker B motif; other site
656519004517	chain length determinant protein tyrosine kinase EpsG; Region: EpsG; TIGR03029
656519004518	Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157
656519004519	general secretory pathway protein E; Region: type_II_gspE; TIGR02533
656519004520	PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129
656519004521	Walker A motif; other site
656519004522	ATP binding site [chemical binding]; other site
656519004523	Walker B motif; other site
656519004524	shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258
656519004525	Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501
656519004526	NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065
656519004527	shikimate binding site; other site
656519004528	NAD(P) binding site [chemical binding]; other site
656519004529	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
656519004530	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
656519004531	ligand binding site [chemical binding]; other site
656519004532	flexible hinge region; other site
656519004533	Helix-turn-helix domains; Region: HTH; cl00088
656519004534	non-specific DNA interactions [nucleotide binding]; other site
656519004535	DNA binding site [nucleotide binding]
656519004536	sequence specific DNA binding site [nucleotide binding]; other site
656519004537	putative cAMP binding site [chemical binding]; other site
656519004538	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153
656519004539	metal binding site 2 [ion binding]; metal-binding site
656519004540	putative DNA binding helix; other site
656519004541	metal binding site 1 [ion binding]; metal-binding site
656519004542	dimer interface [polypeptide binding]; other site
656519004543	structural Zn2+ binding site [ion binding]; other site
656519004544	Antidote-toxin recognition MazE; Region: Antitoxin-MazE; cl00877
656519004545	spore cortex-lytic enzyme; Region: spore_SleB; TIGR02869
656519004546	Putative peptidoglycan binding domain; Region: PG_binding_1; cl15437
656519004547	Cell Wall Hydrolase; Region: Hydrolase_2; pfam07486
656519004548	putative protease; Provisional; Region: PRK15452
656519004549	Peptidase family U32; Region: Peptidase_U32; cl03113
656519004550	Predicted O-methyltransferase [General function prediction only]; Region: COG4122
656519004551	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
656519004552	S-adenosylmethionine binding site [chemical binding]; other site
656519004553	YceG-like family; Region: YceG; pfam02618
656519004554	proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010
656519004555	dimerization interface [polypeptide binding]; other site
656519004556	Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination.  HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD includes...; Region: RuvC_resolvase; cl00243
656519004557	Bacterial protein of unknown function (DUF965); Region: DUF965; cl01857
656519004558	alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252
656519004559	Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent formation of...; Region: AlaRS_core; cd00673
656519004560	motif 1; other site
656519004561	active site
656519004562	motif 2; other site
656519004563	motif 3; other site
656519004564	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; cl08469
656519004565	DHHA1 domain; Region: DHHA1; pfam02272
656519004566	tyrosyl-tRNA synthetase; Validated; Region: PRK05912
656519004567	catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805
656519004568	active site
656519004569	HIGH motif; other site
656519004570	dimer interface [polypeptide binding]; other site
656519004571	KMSKS motif; other site
656519004572	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
656519004573	RNA binding surface [nucleotide binding]; other site
656519004574	Transglycosylase; Region: Transgly; cl07896
656519004575	penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074
656519004576	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009
656519004577	recombination and DNA strand exchange inhibitor protein; Reviewed; Region: PRK00409
656519004578	MutS2 homologs in bacteria and eukaryotes.  The MutS protein initiates DNA mismatch repair by recognizing mispaired and unpaired bases embedded in duplex DNA and activating endo- and exonucleases to remove the mismatch. Members of the MutS family also...; Region: ABC_MutS2; cd03280
656519004579	Walker A/P-loop; other site
656519004580	ATP binding site [chemical binding]; other site
656519004581	Q-loop/lid; other site
656519004582	ABC transporter signature motif; other site
656519004583	Walker B; other site
656519004584	D-loop; other site
656519004585	H-loop/switch region; other site
656519004586	Smr domain; Region: Smr; cl02619
656519004587	hypothetical protein; Provisional; Region: PRK08609
656519004588	Nucleotidyltransferase (NT) domain of family X DNA Polymerases; Region: NT_POLXc; cd00141
656519004589	active site
656519004590	primer binding site [nucleotide binding]; other site
656519004591	NTP  binding site [chemical binding]; other site
656519004592	metal binding triad [ion binding]; metal-binding site
656519004593	Colicin V production protein; Region: Colicin_V; cl00567
656519004594	Cell division protein ZapA; Region: ZapA; cl01146
656519004595	phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629
656519004596	tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain.  PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796
656519004597	putative tRNA-binding site [nucleotide binding]; other site
656519004598	B3/4 domain; Region: B3_4; cl11458
656519004599	tRNA synthetase B5 domain; Region: B5; cl08394
656519004600	Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA,  PheRS is an...; Region: PheRS_beta_core; cd00769
656519004601	dimer interface [polypeptide binding]; other site
656519004602	motif 1; other site
656519004603	motif 3; other site
656519004604	motif 2; other site
656519004605	Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; cl08386
656519004606	phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488
656519004607	Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912
656519004608	Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496
656519004609	dimer interface [polypeptide binding]; other site
656519004610	motif 1; other site
656519004611	active site
656519004612	motif 2; other site
656519004613	motif 3; other site
656519004614	rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566
656519004615	RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; cl06870
656519004616	SpoU rRNA Methylase family; Region: SpoU_methylase; cl00362
656519004617	Ribosomal protein L20; Region: Ribosomal_L20; cd07026
656519004618	23S rRNA binding site [nucleotide binding]; other site
656519004619	L21 binding site [polypeptide binding]; other site
656519004620	L13 binding site [polypeptide binding]; other site
656519004621	Ribosomal protein L35; Region: Ribosomal_L35p; cl00392
656519004622	translation initiation factor IF-3; Reviewed; Region: infC; PRK00028
656519004623	Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198
656519004624	Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707
656519004625	Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer,  utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514
656519004626	FMN binding site [chemical binding]; other site
656519004627	dimer interface [polypeptide binding]; other site
656519004628	Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518
656519004629	threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413
656519004630	TGS _ThrRS_N:  ThrRS (threonyl-tRNA Synthetase)  is a class II tRNA synthetase that couples threonine to its cognate tRNA.  In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667
656519004631	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; cl08469
656519004632	Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771
656519004633	active site
656519004634	dimer interface [polypeptide binding]; other site
656519004635	motif 1; other site
656519004636	motif 2; other site
656519004637	motif 3; other site
656519004638	ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860
656519004639	anticodon binding site; other site
656519004640	Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581
656519004641	Uncharacterized membrane protein [Function unknown]; Region: SapB; COG1285
656519004642	MgtC family; Region: MgtC; pfam02308
656519004643	Leucine-rich repeat (LRR) protein [Function unknown]; Region: COG4886
656519004644	YibE/F-like protein; Region: YibE_F; cl02259
656519004645	Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cd00016
656519004646	active site
656519004647	dimer interface [polypeptide binding]; other site
656519004648	Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cl15837
656519004649	Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826
656519004650	Helix-turn-helix domains; Region: HTH; cl00088
656519004651	Integrase core domain; Region: rve; cl01316
656519004652	Helix-turn-helix domains; Region: HTH; cl00088
656519004653	HTH-like domain; Region: HTH_21; pfam13276
656519004654	Integrase core domain; Region: rve; cl01316
656519004655	Integrase core domain; Region: rve_3; cl15866
656519004656	Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799
656519004657	Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799
656519004658	Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799
656519004659	Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799
656519004660	YibE/F-like protein; Region: YibE_F; cl02259
656519004661	Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cd00016
656519004662	active site
656519004663	dimer interface [polypeptide binding]; other site
656519004664	Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cl15837
656519004665	CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641
656519004666	CRISPR/Cas system-associated protein Cas2; Region: Cas2_I_II_III; cd09725
656519004667	CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-II-III; cd09634
656519004668	CRISPR/Cas system-associated protein Cas3''; Region: Cas3''_I; cd09641
656519004669	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
656519004670	CRISPR-associated helicase Cas3; Region: cas3_core; TIGR01587
656519004671	CRISPR/Cas system-associated RAMP superfamily protein Cas5; Region: Cas5_I; cl12040
656519004672	CRISPR/Cas system-associated RAMP superfamily protein Cas7; Region: Cas7_I-C; cl01465
656519004673	CRISPR/Cas system-associated protein Cas8b; Region: Cas8b_I-B; cl09718
656519004674	Predicted transcriptional regulator [Transcription]; Region: COG2378
656519004675	Helix-turn-helix domains; Region: HTH; cl00088
656519004676	WYL domain; Region: WYL; cl14852
656519004677	Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; cl02930
656519004678	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474
656519004679	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
656519004680	Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246
656519004681	Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391
656519004682	Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689
656519004683	Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105
656519004684	1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164
656519004685	putative substrate binding site [chemical binding]; other site
656519004686	putative ATP binding site [chemical binding]; other site
656519004687	4Fe-4S binding domain; Region: Fer4_5; pfam12801
656519004688	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
656519004689	4Fe-4S dicluster domain; Region: Fer4_7; pfam12838
656519004690	manganese transport transcriptional regulator; Provisional; Region: PRK03902
656519004691	Helix-turn-helix domains; Region: HTH; cl00088
656519004692	Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742
656519004693	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
656519004694	ABC-ATPase subunit  interface; other site
656519004695	dimer interface [polypeptide binding]; other site
656519004696	putative PBP binding regions; other site
656519004697	ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121
656519004698	ABC component of the metal-type transporters.  This family includes transporters involved in the uptake of various metallic cations such as iron, manganese, and zinc.  The ATPases of this group of transporters are very similar to members of...; Region: ABC_Metallic_Cations; cd03235
656519004699	Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+.  Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262
656519004700	Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297
656519004701	intersubunit interface [polypeptide binding]; other site
656519004702	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3296; cl15800
656519004703	flavoprotein, HI0933 family; Region: TIGR00275
656519004704	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
656519004705	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
656519004706	peptidyl-prolyl cis-trans isomerase B (rotamase B); Provisional; Region: PRK10791
656519004707	cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317
656519004708	active site
656519004709	Mechanosensitive ion channel; Region: MS_channel; pfam00924
656519004710	FAD binding domain; Region: FAD_binding_4; pfam01565
656519004711	glycolate oxidase, subunit GlcD; Region: glcD; TIGR00387
656519004712	Integrase core domain; Region: rve; cl01316
656519004713	DDE domain; Region: DDE_Tnp_IS240; pfam13610
656519004714	Integrase core domain; Region: rve_3; cl15866
656519004715	The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715
656519004716	Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025
656519004717	Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766
656519004718	The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714
656519004719	Ligand binding site [chemical binding]; other site
656519004720	Electron transfer flavoprotein domain; Region: ETF; pfam01012
656519004721	Uncharacterized membrane protein [Function unknown]; Region: COG3949
656519004722	Putative peptidoglycan binding domain; Region: PG_binding_1; cl15437
656519004723	FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388
656519004724	Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118
656519004725	putative peptidoglycan binding site; other site
656519004726	Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118
656519004727	putative peptidoglycan binding site; other site
656519004728	Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118
656519004729	putative peptidoglycan binding site; other site
656519004730	Peptidase family M23; Region: Peptidase_M23; pfam01551
656519004731	SpoU rRNA Methylase family; Region: SpoU_methylase; cl00362
656519004732	Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446
656519004733	ECF-type riboflavin transporter, S component; Region: ECF-ribofla_trS; cl01942
656519004734	putative PEP-CTERM system TPR-repeat lipoprotein; Region: PEP_TPR_lipo; TIGR02917
656519004735	Stage II sporulation protein; Region: SpoIID; pfam08486
656519004736	SpoIID/LytB domain; Region: SpoIID_LytB; TIGR02669
656519004737	NYN ribonuclease and ATPase of PhoH family domains [General    function prediction only]; Region: COG1875
656519004738	PIN domain of bacterial Smg6-like homologs with PhoH-like ATPase domains; Region: PIN_PhoHL-ATPase; cd09883
656519004739	putative active site [active]
656519004740	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
656519004741	Domain of unknown function (DUF296); Region: DUF296; cl00720
656519004742	Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177
656519004743	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
656519004744	minor groove reading motif; other site
656519004745	helix-hairpin-helix signature motif; other site
656519004746	substrate binding pocket [chemical binding]; other site
656519004747	active site
656519004748	Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; cl15304
656519004749	Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391
656519004750	Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419
656519004751	threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413
656519004752	Uridine kinase [Nucleotide transport and metabolism]; Region: Udk; COG0572
656519004753	Uridine monophosphate kinase_like (UMPK_like) is a family of proteins highly similar to the uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK); Region: UMPK_like; cd02028
656519004754	active site
656519004755	Uncharacterized Fe-S protein [Energy production and conversion]; Region: COG1600
656519004756	Major Facilitator Superfamily; Region: MFS_1; pfam07690
656519004757	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
656519004758	putative substrate translocation pore; other site
656519004759	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
656519004760	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
656519004761	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
656519004762	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
656519004763	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
656519004764	Uncharacterized protein family (UPF0182); Region: UPF0182; pfam03699
656519004765	Uncharacterized conserved protein [Function unknown]; Region: COG1615; cl09133
656519004766	N-ethylammeline chlorohydrolase; Provisional; Region: PRK06038
656519004767	TRZ/ATZ family contains enzymes from the atrazine degradation pathway and related hydrolases. Atrazine, a chlorinated herbizide, can be catabolized by a variety of different bacteria. The first three steps of the atrazine dehalogenation pathway are...; Region: ATZ_TRZ_like; cd01298
656519004768	active site
656519004769	putative substrate binding pocket [chemical binding]; other site
656519004770	CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453
656519004771	photolyase PhrII; Region: phr2; TIGR00591
656519004772	DNA photolyase; Region: DNA_photolyase; pfam00875
656519004773	FAD binding domain of DNA photolyase; Region: FAD_binding_7; pfam03441
656519004774	Mechanosensitive ion channel; Region: MS_channel; pfam00924
656519004775	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
656519004776	IHF - DNA interface [nucleotide binding]; other site
656519004777	IHF dimer interface [polypeptide binding]; other site
656519004778	NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094
656519004779	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
656519004780	NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479
656519004781	Glycerol-3-phosphate acyltransferase; Region: G3P_acyltransf; cl00410
656519004782	GTP-binding protein Der; Reviewed; Region: PRK00093
656519004783	EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894
656519004784	G1 box; other site
656519004785	GTP/Mg2+ binding site [chemical binding]; other site
656519004786	Switch I region; other site
656519004787	G2 box; other site
656519004788	Switch II region; other site
656519004789	G3 box; other site
656519004790	G4 box; other site
656519004791	G5 box; other site
656519004792	EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895
656519004793	G1 box; other site
656519004794	GTP/Mg2+ binding site [chemical binding]; other site
656519004795	Switch I region; other site
656519004796	G2 box; other site
656519004797	G3 box; other site
656519004798	Switch II region; other site
656519004799	G4 box; other site
656519004800	G5 box; other site
656519004801	PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989
656519004802	putative FeS-containing Cyanobacterial-specific oxidoreductase; Region: cyano_FeS_chp; TIGR03279
656519004803	Protein of unknown function (DUF512); Region: DUF512; pfam04459
656519004804	(E)-4-hydroxy-3-methyl-but-2-enyl pyrophosphate reductase (IPP and DMAPP forming); Region: ispH_lytB; TIGR00216
656519004805	LytB protein; Region: LYTB; cl00507
656519004806	S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec1_hs1; cd05687
656519004807	RNA binding site [nucleotide binding]; other site
656519004808	S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec2_hs2; cd04465
656519004809	RNA binding site [nucleotide binding]; other site
656519004810	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
656519004811	RNA binding site [nucleotide binding]; other site
656519004812	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
656519004813	RNA binding site [nucleotide binding]; other site
656519004814	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
656519004815	putative acyl-acceptor binding pocket; other site
656519004816	cytidylate kinase; Provisional; Region: cmk; PRK00023
656519004817	Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020
656519004818	CMP-binding site; other site
656519004819	The sites determining sugar specificity; other site
656519004820	Chorismate mutase (AroH) is one of at least five chorismate-utilizing enzymes present in microorganisms that catalyze the rearrangement of chorismate to prephenic acid, the first committed step in the biosynthesis of aromatic amino acids. In prokaryotes; Region: AroH; cd02185
656519004821	homotrimer interaction site [polypeptide binding]; other site
656519004822	active site
656519004823	ribonuclease III; Reviewed; Region: rnc; PRK00102
656519004824	RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593
656519004825	dimerization interface [polypeptide binding]; other site
656519004826	active site
656519004827	metal binding site [ion binding]; metal-binding site
656519004828	Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048
656519004829	dsRNA binding site [nucleotide binding]; other site
656519004830	Phosphopantetheine attachment site; Region: PP-binding; cl09936
656519004831	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557
656519004832	beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333
656519004833	NAD(P) binding site [chemical binding]; other site
656519004834	homotetramer interface [polypeptide binding]; other site
656519004835	homodimer interface [polypeptide binding]; other site
656519004836	active site
656519004837	putative enoyl-[acyl-carrier-protein] reductase II; Region: enACPred_II; TIGR03151
656519004838	2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730
656519004839	FMN binding site [chemical binding]; other site
656519004840	substrate binding site [chemical binding]; other site
656519004841	putative catalytic residue [active]
656519004842	Phosphate acetyl/butaryl transferase; Region: PTA_PTB; cl00390
656519004843	Ribosomal L32p protein family; Region: Ribosomal_L32p; cl09115
656519004844	Uncharacterized ACR, COG1399; Region: DUF177; cl00616
656519004845	Acetokinase family; Region: Acetate_kinase; cl01029
656519004846	propionate/acetate kinase; Provisional; Region: PRK12379
656519004847	Phosphate acetyl/butaryl transferase; Region: PTA_PTB; cl00390
656519004848	Phosphotransacetylase [Energy production and conversion]; Region: Pta; COG0280
656519004849	hypothetical protein; Provisional; Region: PRK13670
656519004850	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
656519004851	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
656519004852	protein binding site [polypeptide binding]; other site
656519004853	Subunit ChlI of Mg-chelatase; Region: ChlI; cl12214
656519004854	hypothetical protein; Provisional; Region: PRK10279
656519004855	Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396
656519004856	nucleophile elbow; other site
656519004857	Na+/H+ antiporter [Energy production and conversion]; Region: NhaC; COG1757
656519004858	This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily  includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which  binds to Adenosine group.  This subfamily; Region: Alpha_ANH_like_II; cd01993
656519004859	Ligand Binding Site [chemical binding]; other site
656519004860	hypothetical protein; Provisional; Region: PRK11770
656519004861	Domain of unknown function (DUF307); Region: DUF307; pfam03733
656519004862	Domain of unknown function (DUF307); Region: DUF307; pfam03733
656519004863	UbiA prenyltransferase family; Region: UbiA; cl00337
656519004864	phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168
656519004865	Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163
656519004866	active site
656519004867	(T/H)XGH motif; other site
656519004868	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
656519004869	S-adenosylmethionine binding site [chemical binding]; other site
656519004870	ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917
656519004871	RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488
656519004872	generic binding surface II; other site
656519004873	ssDNA binding site; other site
656519004874	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
656519004875	ATP binding site [chemical binding]; other site
656519004876	putative Mg++ binding site [ion binding]; other site
656519004877	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
656519004878	nucleotide binding region [chemical binding]; other site
656519004879	ATP-binding site [chemical binding]; other site
656519004880	Uncharacterized protein, DegV family COG1307; Region: DegV; cl00577
656519004881	DAK2 domain fusion protein YloV; Region: YloV; TIGR03599
656519004882	DAK2 domain; Region: Dak2; cl03685
656519004883	Uncharacterized protein, DegV family COG1307; Region: DegV; cl00577
656519004884	Asp23 family; Region: Asp23; cl00574
656519004885	Ribosomal L28 family; Region: Ribosomal_L28; cl00367
656519004886	Thiamine pyrophosphokinase; Region: TPK; cd07995
656519004887	thiamine pyrophosphokinase; Region: thi_PPkinase; TIGR01378
656519004888	active site
656519004889	dimerization interface [polypeptide binding]; other site
656519004890	thiamine binding site [chemical binding]; other site
656519004891	Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429
656519004892	ribulose-phosphate 3-epimerase; Region: rpe; TIGR01163
656519004893	substrate binding site [chemical binding]; other site
656519004894	hexamer interface [polypeptide binding]; other site
656519004895	metal binding site [ion binding]; metal-binding site
656519004896	GTPase RsgA; Reviewed; Region: PRK00098
656519004897	S1_YloQ_GTPase: YloQ GTase family (also known as YjeQ and CpgA), S1-like RNA-binding domain. Proteins in the YloQ GTase family bind the ribosome and have GTPase activity. The precise role of this family is unknown. The protein structure is composed of...; Region: S1_YloQ_GTPase; cd04466
656519004898	RNA binding site [nucleotide binding]; other site
656519004899	homodimer interface [polypeptide binding]; other site
656519004900	Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854
656519004901	GTPase/Zn-binding domain interface [polypeptide binding]; other site
656519004902	GTP/Mg2+ binding site [chemical binding]; other site
656519004903	G4 box; other site
656519004904	G5 box; other site
656519004905	G1 box; other site
656519004906	Switch I region; other site
656519004907	G2 box; other site
656519004908	G3 box; other site
656519004909	Switch II region; other site
656519004910	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
656519004911	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
656519004912	active site
656519004913	ATP binding site [chemical binding]; other site
656519004914	substrate binding site [chemical binding]; other site
656519004915	activation loop (A-loop); other site
656519004916	PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577
656519004917	PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577
656519004918	PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577
656519004919	Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143
656519004920	Protein phosphatase 2C; Region: PP2C; pfam00481
656519004921	active site
656519004922	ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK14454
656519004923	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
656519004924	FeS/SAM binding site; other site
656519004925	16S rRNA methyltransferase B; Provisional; Region: PRK14902
656519004926	RNA binding domain of NusB (N protein-Utilization Substance B) and Sun (also known as RrmB or Fmu) proteins. This family includes two orthologous groups exemplified by the transcription termination factor NusB and the N-terminal domain of the...; Region: NusB_Sun; cl00223
656519004927	putative RNA binding site [nucleotide binding]; other site
656519004928	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
656519004929	S-adenosylmethionine binding site [chemical binding]; other site
656519004930	Putative neutral zinc metallopeptidase; Region: Zn_peptidase_2; cl01049
656519004931	methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005
656519004932	Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646
656519004933	putative active site [active]
656519004934	substrate binding site [chemical binding]; other site
656519004935	putative cosubstrate binding site; other site
656519004936	catalytic site [active]
656519004937	C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704
656519004938	substrate binding site [chemical binding]; other site
656519004939	Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487
656519004940	active site
656519004941	catalytic residues [active]
656519004942	metal binding site [ion binding]; metal-binding site
656519004943	Primosomal protein N' (replication factor Y) - superfamily II helicase [DNA replication, recombination, and repair]; Region: PriA; COG1198
656519004944	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
656519004945	S-adenosylmethionine synthetase; Validated; Region: PRK05250
656519004946	S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438
656519004947	S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772
656519004948	S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773
656519004949	Prolipoprotein diacylglyceryl transferase; Region: LGT; cl00478
656519004950	Flavoprotein; Region: Flavoprotein; cl08021
656519004951	bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579
656519004952	DNA / pantothenate metabolism flavoprotein; Region: DFP; cl04410
656519004953	RNA polymerase Rpb6; Region: RNA_pol_Rpb6; cl14651
656519004954	Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194
656519004955	Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071
656519004956	catalytic site [active]
656519004957	G-X2-G-X-G-K; other site
656519004958	Domain of unknown function (DUF370); Region: DUF370; cl00898
656519004959	Fibronectin-binding protein A N-terminus (FbpA); Region: FbpA; pfam05833
656519004960	Domain of unknown function (DUF814); Region: DUF814; pfam05670
656519004961	Apolipoprotein N-acyltransferase [Cell envelope biogenesis, outer membrane]; Region: Lnt; COG0815
656519004962	Elongation factor G (EF-G) family; Region: EF-G_bact; cd04170
656519004963	elongation factor G; Reviewed; Region: PRK12740
656519004964	G1 box; other site
656519004965	putative GEF interaction site [polypeptide binding]; other site
656519004966	GTP/Mg2+ binding site [chemical binding]; other site
656519004967	Switch I region; other site
656519004968	G2 box; other site
656519004969	G3 box; other site
656519004970	Switch II region; other site
656519004971	G4 box; other site
656519004972	G5 box; other site
656519004973	EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088
656519004974	EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434
656519004975	EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G.  Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713
656519004976	Uncharacterized flavoproteins [Energy production and conversion]; Region: FpaA; COG0426
656519004977	Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446
656519004978	NADPH-dependent FMN reductase; Region: FMN_red; cl00438
656519004979	pseudouridine synthase, RluA family; Region: rluA_subfam; TIGR00005
656519004980	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cl09940
656519004981	PseudoU_synth_RsuA/RluD: Pseudouridine synthase, RsuA/RluD family. This group is comprised of eukaryotic, bacterial and archeal proteins similar to eight site specific Escherichia coli pseudouridine synthases: RsuA, RluA, RluB, RluC, RluD, RluE, RluF and...; Region: PseudoU_synth_RluCD_like; cd02869
656519004982	active site
656519004983	Signal peptidase (SPase) II; Region: Peptidase_A8; cl00458
656519004984	isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743
656519004985	catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818
656519004986	HIGH motif; other site
656519004987	catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818
656519004988	active site
656519004989	KMSKS motif; other site
656519004990	Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960
656519004991	tRNA binding surface [nucleotide binding]; other site
656519004992	anticodon binding site; other site
656519004993	Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827
656519004994	DivIVA protein; Region: DivIVA; pfam05103
656519004995	DivIVA domain; Region: DivI1A_domain; TIGR03544
656519004996	Uncharacterized conserved protein, contains S4-like domain [Function unknown]; Region: COG2302
656519004997	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
656519004998	RNA binding surface [nucleotide binding]; other site
656519004999	YGGT family; Region: YGGT; cl00508
656519005000	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635
656519005001	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
656519005002	catalytic residue [active]
656519005003	HlyD family secretion protein; Region: HlyD_2; pfam12700
656519005004	Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404
656519005005	cell division protein FtsZ; Validated; Region: PRK09330
656519005006	FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes.  FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201
656519005007	nucleotide binding site [chemical binding]; other site
656519005008	SulA interaction site; other site
656519005009	cell division protein FtsA; Region: ftsA; TIGR01174
656519005010	Cell division protein FtsA; Region: FtsA; cl11496
656519005011	Cell division protein FtsA; Region: FtsA; cl11496
656519005012	Cell division septal protein [Cell envelope biogenesis, outer membrane]; Region: FtsQ; COG1589
656519005013	POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478
656519005014	UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421
656519005015	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
656519005016	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
656519005017	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
656519005018	undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726
656519005019	MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785
656519005020	homodimer interface [polypeptide binding]; other site
656519005021	active site
656519005022	Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511
656519005023	UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK14106
656519005024	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
656519005025	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
656519005026	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
656519005027	Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852
656519005028	Mg++ binding site [ion binding]; other site
656519005029	putative catalytic motif [active]
656519005030	putative substrate binding site [chemical binding]; other site
656519005031	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
656519005032	UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase; Region: murF; TIGR01143
656519005033	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
656519005034	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
656519005035	UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139
656519005036	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
656519005037	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
656519005038	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
656519005039	stage V sporulation protein D; Region: spoVD_pbp; TIGR02214
656519005040	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
656519005041	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009
656519005042	PASTA domain of PBP2x-like proteins, first repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_1; cd06576
656519005043	PASTA domain of PBP2x-like proteins, second repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_2; cd06575
656519005044	Predicted S-adenosylmethionine-dependent methyltransferase involved in cell envelope biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG0275
656519005045	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
656519005046	cell division protein MraZ; Reviewed; Region: PRK00326
656519005047	MraZ protein; Region: MraZ; pfam02381
656519005048	MraZ protein; Region: MraZ; pfam02381
656519005049	DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586
656519005050	active site
656519005051	DNA polymerase IV; Validated; Region: PRK02406
656519005052	DNA binding site [nucleotide binding]
656519005053	D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966
656519005054	D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820
656519005055	ATP-grasp domain; Region: ATP-grasp_4; cl03087
656519005056	tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282
656519005057	catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806
656519005058	active site
656519005059	HIGH motif; other site
656519005060	dimer interface [polypeptide binding]; other site
656519005061	KMSKS motif; other site
656519005062	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153
656519005063	metal binding site 2 [ion binding]; metal-binding site
656519005064	putative DNA binding helix; other site
656519005065	metal binding site 1 [ion binding]; metal-binding site
656519005066	dimer interface [polypeptide binding]; other site
656519005067	structural Zn2+ binding site [ion binding]; other site
656519005068	Carboxymuconolactone decarboxylase family; Region: CMD; cl00460
656519005069	RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278
656519005070	RNA/DNA hybrid binding site [nucleotide binding]; other site
656519005071	active site
656519005072	Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080
656519005073	PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524
656519005074	PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; cl01586
656519005075	Pyruvate kinase (PK):  Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl09155
656519005076	Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367
656519005077	dimerization domain swap beta strand [polypeptide binding]; other site
656519005078	regulatory protein interface [polypeptide binding]; other site
656519005079	active site
656519005080	regulatory phosphorylation site [posttranslational modification]; other site
656519005081	Glycerol-3-phosphate responsive antiterminator; Region: G3P_antiterm; cl00852
656519005082	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
656519005083	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992
656519005084	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
656519005085	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
656519005086	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
656519005087	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
656519005088	Predicted dehydrogenase [General function prediction only]; Region: COG0579
656519005089	BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; cl01093
656519005090	nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790
656519005091	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
656519005092	dimer interface [polypeptide binding]; other site
656519005093	conserved gate region; other site
656519005094	ABC-ATPase subunit interface; other site
656519005095	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
656519005096	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
656519005097	dimer interface [polypeptide binding]; other site
656519005098	conserved gate region; other site
656519005099	putative PBP binding loops; other site
656519005100	ABC-ATPase subunit interface; other site
656519005101	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
656519005102	The substrate-binding component of an uncharacterized ABC-type peptide import system Ylib contains the type 2 periplasmic binding fold; Region: PBP2_Ylib_like; cd08499
656519005103	tRNA methyl transferase; Region: tRNA_Me_trans; pfam03054
656519005104	tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998
656519005105	Ligand Binding Site [chemical binding]; other site
656519005106	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
656519005107	cysteine desulfurase DndA; Region: DNA_S_dndA; TIGR03235
656519005108	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
656519005109	catalytic residue [active]
656519005110	Helix-turn-helix domains; Region: HTH; cl00088
656519005111	Rrf2 family protein; Region: rrf2_super; TIGR00738
656519005112	uncharacterized protein, YigZ family; Region: IMPACT_YIGZ; TIGR00257
656519005113	Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205
656519005114	recombination factor protein RarA; Reviewed; Region: PRK13342
656519005115	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
656519005116	Walker A motif; other site
656519005117	ATP binding site [chemical binding]; other site
656519005118	Walker B motif; other site
656519005119	arginine finger; other site
656519005120	MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002
656519005121	5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; cl00360
656519005122	aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476
656519005123	EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317
656519005124	dimer interface [polypeptide binding]; other site
656519005125	anticodon binding site; other site
656519005126	Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of the...; Region: AspRS_core; cd00777
656519005127	homodimer interface [polypeptide binding]; other site
656519005128	motif 1; other site
656519005129	active site
656519005130	motif 2; other site
656519005131	GAD domain; Region: GAD; pfam02938
656519005132	Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of the...; Region: AspRS_core; cd00777
656519005133	motif 3; other site
656519005134	histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037
656519005135	Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: HisRS-like_core; cd00773
656519005136	dimer interface [polypeptide binding]; other site
656519005137	motif 1; other site
656519005138	active site
656519005139	motif 2; other site
656519005140	motif 3; other site
656519005141	HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859
656519005142	anticodon binding site; other site
656519005143	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
656519005144	TPR motif; other site
656519005145	Tetratricopeptide repeat; Region: TPR_16; pfam13432
656519005146	binding surface
656519005147	Tetratricopeptide repeat; Region: TPR_16; pfam13432
656519005148	Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446
656519005149	D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563
656519005150	putative active site [active]
656519005151	dimerization interface [polypeptide binding]; other site
656519005152	putative tRNAtyr binding site [nucleotide binding]; other site
656519005153	Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317
656519005154	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076
656519005155	Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399
656519005156	synthetase active site [active]
656519005157	NTP binding site [chemical binding]; other site
656519005158	metal binding site [ion binding]; metal-binding site
656519005159	TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668
656519005160	ACT  domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876
656519005161	Adenine/guanine phosphoribosyltransferases and related PRPP-binding proteins [Nucleotide transport and metabolism]; Region: Apt; COG0503
656519005162	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
656519005163	active site
656519005164	single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644
656519005165	DHH family; Region: DHH; pfam01368
656519005166	DHHA1 domain; Region: DHHA1; pfam02272
656519005167	Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661
656519005168	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
656519005169	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: APH_ChoK_like; cd05120
656519005170	active site
656519005171	ATP binding site [chemical binding]; other site
656519005172	preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022
656519005173	Protein export membrane protein; Region: SecD_SecF; cl14618
656519005174	SecD/SecF GG Motif; Region: Sec_GG; pfam07549
656519005175	preprotein translocase subunit SecD; Reviewed; Region: secD; PRK05812
656519005176	Protein export membrane protein; Region: SecD_SecF; cl14618
656519005177	signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227
656519005178	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
656519005179	Catalytic site [active]
656519005180	Preprotein translocase subunit; Region: YajC; cl00806
656519005181	queuine tRNA-ribosyltransferase; Provisional; Region: tgt; cl00409
656519005182	tRNA-guanine transglycosylases, various specificities; Region: tgt_general; TIGR00449
656519005183	S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147
656519005184	Queuosine biosynthesis protein; Region: Queuosine_synth; cl00523
656519005185	Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080
656519005186	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
656519005187	Walker A motif; other site
656519005188	ATP binding site [chemical binding]; other site
656519005189	Walker B motif; other site
656519005190	arginine finger; other site
656519005191	Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491
656519005192	Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116
656519005193	RuvA N terminal domain; Region: RuvA_N; pfam01330
656519005194	RuvA, C-terminal domain; Region: RuvA_C; pfam07499
656519005195	Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination.  HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD includes...; Region: RuvC_resolvase; cd00529
656519005196	active site
656519005197	putative DNA-binding cleft [nucleotide binding]; other site
656519005198	dimer interface [polypeptide binding]; other site
656519005199	Transcriptional regulator; Region: Transcrip_reg; cl00361
656519005200	NIF3 (NGG1p interacting factor 3); Region: NIF3; cl15371
656519005201	NIF3 (NGG1p interacting factor 3); Region: NIF3; cl15371
656519005202	NIF3 (NGG1p interacting factor 3); Region: NIF3; cl15371
656519005203	RNA polymerase sigma factor RpoD; Validated; Region: PRK09210
656519005204	Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979
656519005205	Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140
656519005206	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
656519005207	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
656519005208	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
656519005209	DNA binding residues [nucleotide binding]
656519005210	DNA primase, catalytic core; Region: dnaG; TIGR01391
656519005211	CHC2 zinc finger; Region: zf-CHC2; cl15369
656519005212	DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275
656519005213	TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364
656519005214	active site
656519005215	metal binding site [ion binding]; metal-binding site
656519005216	interdomain interaction site; other site
656519005217	DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410
656519005218	deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional; Region: PRK01286
656519005219	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
656519005220	Zn2+ binding site [ion binding]; other site
656519005221	Mg2+ binding site [ion binding]; other site
656519005222	Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286
656519005223	Kinase/pyrophosphorylase; Region: Kinase-PPPase; cl00780
656519005224	glycyl-tRNA synthetase subunit beta; Validated; Region: glyS; PRK01233
656519005225	Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020
656519005226	Class II Glycyl-tRNA synthetase (GlyRS) alpha subunit core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes and in arabidopsis. It is responsible for the...; Region: GlyRS_alpha_core; cd00733
656519005227	dimer interface [polypeptide binding]; other site
656519005228	motif 1; other site
656519005229	active site
656519005230	motif 2; other site
656519005231	motif 3; other site
656519005232	Recombination protein O N terminal; Region: RecO_N; cl15812
656519005233	DNA repair protein RecO; Region: reco; TIGR00613
656519005234	Recombination protein O C terminal; Region: RecO_C; pfam02565
656519005235	2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959
656519005236	intersubunit interface [polypeptide binding]; other site
656519005237	active site
656519005238	catalytic residue [active]
656519005239	Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239
656519005240	MgtE intracellular N domain; Region: MgtE_N; cl15244
656519005241	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE.  MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606
656519005242	Divalent cation transporter; Region: MgtE; cl00786
656519005243	GTPase Era; Reviewed; Region: era; PRK00089
656519005244	E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163
656519005245	G1 box; other site
656519005246	GTP/Mg2+ binding site [chemical binding]; other site
656519005247	Switch I region; other site
656519005248	G2 box; other site
656519005249	Switch II region; other site
656519005250	G3 box; other site
656519005251	G4 box; other site
656519005252	G5 box; other site
656519005253	Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283
656519005254	active site
656519005255	catalytic motif [active]
656519005256	Zn binding site [ion binding]; other site
656519005257	Protein of unknown function (DUF3048); Region: DUF3048; pfam11258
656519005258	Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253
656519005259	Domain of unknown function DUF21; Region: DUF21; pfam01595
656519005260	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
656519005261	Transporter associated domain; Region: CorC_HlyC; cl08393
656519005262	Prokaryotic diacylglycerol kinase; Region: DAGK_prokar; cl00526
656519005263	PAP2_like proteins, diacylglycerol_kinase like sub-family. In some prokaryotes, PAP2_like phosphatase domains appear fused to E. coli DAGK-like trans-membrane diacylglycerol kinase domains. The cellular function of these architectures remains to be...; Region: PAP2_diacylglycerolkinase; cd03383
656519005264	active site
656519005265	Uncharacterized protein family UPF0054; Region: UPF0054; cl00402
656519005266	Predicted membrane-associated HD superfamily hydrolase [General function prediction only]; Region: COG1480
656519005267	7TM receptor with intracellular HD hydrolase; Region: 7TM-7TMR_HD; pfam07698
656519005268	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
656519005269	Zn2+ binding site [ion binding]; other site
656519005270	Mg2+ binding site [ion binding]; other site
656519005271	Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702
656519005272	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
656519005273	SigmaW regulon antibacterial; Region: YdfA_immunity; cl12057
656519005274	Membrane-bound serine protease (ClpP class) [Posttranslational modification, protein turnover, chaperones]; Region: NfeD; COG1030
656519005275	Nodulation formation efficiency D (NfeD) is a membrane-bound ClpP-class protease; Region: Clp_protease_NfeD_like; cd07021
656519005276	dimer interface [polypeptide binding]; other site
656519005277	active site residues [active]
656519005278	NfeD-like C-terminal, partner-binding; Region: NfeD; cl00686
656519005279	GatB domain; Region: GatB_Yqey; cl11497
656519005280	Protein Kinase C Interacting protein related (PKCI): PKCI and related proteins belong to the ubiquitous HIT family of hydrolases that act on alpha-phosphates of ribonucleotides. The members of this subgroup have a conserved HxHxHxx motif (x is a...; Region: PKCI_related; cd01276
656519005281	nucleotide binding site/active site [active]
656519005282	HIT family signature motif; other site
656519005283	catalytic residue [active]
656519005284	radical SAM methylthiotransferase, MiaB/RimO family; Region: TIGR00089
656519005285	Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919
656519005286	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
656519005287	FeS/SAM binding site; other site
656519005288	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1385; cl00611
656519005289	RNA methyltransferase; Region: Methyltrans_RNA; pfam04452
656519005290	chaperone protein DnaJ; Provisional; Region: PRK10767
656519005291	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
656519005292	HSP70 interaction site [polypeptide binding]; other site
656519005293	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262
656519005294	substrate binding site [polypeptide binding]; other site
656519005295	Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719
656519005296	Zn binding sites [ion binding]; other site
656519005297	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747
656519005298	dimer interface [polypeptide binding]; other site
656519005299	molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290
656519005300	GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446
656519005301	dimer interface [polypeptide binding]; other site
656519005302	hsp70 (ATPase domain) interactions [polypeptide binding]; other site
656519005303	heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082
656519005304	Helix-turn-helix domains; Region: HTH; cl00088
656519005305	HrcA protein C terminal domain; Region: HrcA; pfam01628
656519005306	coproporphyrinogen III oxidase; Provisional; Region: PRK08599
656519005307	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
656519005308	FeS/SAM binding site; other site
656519005309	HemN C-terminal domain; Region: HemN_C; pfam06969
656519005310	GTP-binding protein LepA; Provisional; Region: PRK05433
656519005311	LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890
656519005312	G1 box; other site
656519005313	putative GEF interaction site [polypeptide binding]; other site
656519005314	GTP/Mg2+ binding site [chemical binding]; other site
656519005315	Switch I region; other site
656519005316	G2 box; other site
656519005317	G3 box; other site
656519005318	Switch II region; other site
656519005319	G4 box; other site
656519005320	G5 box; other site
656519005321	lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699
656519005322	lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane.   LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709
656519005323	GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421
656519005324	Ribosomal protein S20; Region: Ribosomal_S20p; cl00384
656519005325	DNA polymerase III subunit delta; Reviewed; Region: holA; PRK05574
656519005326	DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144
656519005327	DNA internalization-related competence protein ComEC/Rec2; Region: ComEC_Rec2; TIGR00361
656519005328	Competence protein; Region: Competence; cl00471
656519005329	Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446
656519005330	SLBB domain; Region: SLBB; pfam10531
656519005331	comEA protein; Region: comE; TIGR01259
656519005332	Uridine kinase [Nucleotide transport and metabolism]; Region: Udk; COG0572
656519005333	Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage pathway; Region: UMPK; cd02023
656519005334	ATP-binding site [chemical binding]; other site
656519005335	Sugar specificity; other site
656519005336	Pyrimidine base specificity; other site
656519005337	Protein of unknown function (DUF3343); Region: DUF3343; pfam11823
656519005338	Hypothetical patatin similar to Z1214 protein of Escherichia coli; Region: Pat_hypo_Ecoli_Z1214_like; cd07209
656519005339	active site
656519005340	nucleophile elbow; other site
656519005341	Cytidylate kinase-like family; Region: Cytidylate_kin2; pfam13189
656519005342	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
656519005343	active site
656519005344	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
656519005345	active site
656519005346	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
656519005347	metal-binding site [ion binding]
656519005348	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217
656519005349	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
656519005350	metal-binding site [ion binding]
656519005351	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
656519005352	Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391
656519005353	Predicted acetyltransferase [General function prediction only]; Region: COG3153
656519005354	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
656519005355	Coenzyme A binding pocket [chemical binding]; other site
656519005356	ornithine carbamoyltransferase; Validated; Region: PRK02102
656519005357	Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729
656519005358	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
656519005359	Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534
656519005360	MatE; Region: MatE; cl10513
656519005361	MatE; Region: MatE; cl10513
656519005362	Positive regulator of sigma(E), RseC/MucC; Region: RseC_MucC; cl01178
656519005363	leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390
656519005364	catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812
656519005365	HIGH motif; other site
656519005366	Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603
656519005367	catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812
656519005368	active site
656519005369	KMSKS motif; other site
656519005370	Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958
656519005371	tRNA binding surface [nucleotide binding]; other site
656519005372	Oligomerisation domain; Region: Oligomerisation; cl00519
656519005373	Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581
656519005374	LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399
656519005375	Predicted HD superfamily hydrolase involved in NAD metabolism [Coenzyme metabolism]; Region: COG1713
656519005376	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076
656519005377	nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071
656519005378	Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165
656519005379	active site
656519005380	(T/H)XGH motif; other site
656519005381	Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663
656519005382	Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645
656519005383	trimer interface [polypeptide binding]; other site
656519005384	putative metal binding site [ion binding]; other site
656519005385	Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; cl14105
656519005386	Homocysteine S-methyltransferase; Region: S-methyl_trans; pfam02574
656519005387	Pterin binding enzymes. This family includes dihydropteroate synthase (DHPS) and cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH).  DHPS, a...; Region: Pterin_binding; cl00219
656519005388	substrate binding pocket [chemical binding]; other site
656519005389	dimer interface [polypeptide binding]; other site
656519005390	inhibitor binding site; inhibition site
656519005391	B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293
656519005392	B12 binding site [chemical binding]; other site
656519005393	Head-Tail Connector Proteins gp6 and gp15, and similar proteins; Region: gp6_gp15_like; cl12049
656519005394	Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965
656519005395	Methylenetetrahydrofolate reductase; Region: MTHFR; pfam02219
656519005396	Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537
656519005397	FAD binding site [chemical binding]; other site
656519005398	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
656519005399	metal-binding site [ion binding]
656519005400	Short C-terminal domain; Region: SHOCT; cl01373
656519005401	Short C-terminal domain; Region: SHOCT; cl01373
656519005402	Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031
656519005403	CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561
656519005404	dimer interface [polypeptide binding]; other site
656519005405	pyridoxal 5'-phosphate binding site [chemical binding]; other site
656519005406	catalytic residue [active]
656519005407	Rrf2 family protein; Region: rrf2_super; TIGR00738
656519005408	Helix-turn-helix domains; Region: HTH; cl00088
656519005409	Predicted RNA-bindining protein (contains S1 and HTH domains) [General function prediction only]; Region: COG2996
656519005410	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
656519005411	RNA binding site [nucleotide binding]; other site
656519005412	hypothetical protein; Reviewed; Region: PRK09588
656519005413	Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein; Region: Hint; cl15780
656519005414	Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597
656519005415	Diacylglycerol kinase catalytic domain; Region: DAGK_cat; cl01255
656519005416	Oxalate/Formate Antiporter; Region: 2A0111; TIGR00890
656519005417	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
656519005418	putative substrate translocation pore; other site
656519005419	Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490
656519005420	putative catalytic site [active]
656519005421	putative metal binding site [ion binding]; other site
656519005422	putative phosphate binding site [ion binding]; other site
656519005423	Sodium:solute symporter family; Region: SSF; cl00456
656519005424	Protein-L-isoaspartate carboxylmethyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: Pcm; COG2518
656519005425	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
656519005426	S-adenosylmethionine binding site [chemical binding]; other site
656519005427	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2989
656519005428	Putative peptidoglycan binding domain; Region: PG_binding_1; cl15437
656519005429	L,D-transpeptidase catalytic domain; Region: YkuD; cl15405
656519005430	L,D-transpeptidase catalytic domain; Region: YkuD; cl15405
656519005431	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
656519005432	Helix-turn-helix domains; Region: HTH; cl00088
656519005433	NAD(P)H:flavin oxidoreductase-like family 1.  A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes; Region: NADPH_oxidoreductase_1; cd02150
656519005434	putative FMN binding site [chemical binding]; other site
656519005435	Sodium:neurotransmitter symporter family; Region: SNF; cl11976
656519005436	SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265
656519005437	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
656519005438	S-adenosylmethionine binding site [chemical binding]; other site
656519005439	HutP; Region: HutP; cl07944
656519005440	Type I periplasmic ligand-binding domain of uncharacterized ABC-type transport systems that are predicted to be involved in the uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_uncharacterized_transporter; cd06325
656519005441	Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407
656519005442	zinc binding site [ion binding]; other site
656519005443	putative ligand binding site [chemical binding]; other site
656519005444	Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cd06574
656519005445	TM-ABC transporter signature motif; other site
656519005446	ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: PhnK; COG1101
656519005447	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
656519005448	Walker A/P-loop; other site
656519005449	ATP binding site [chemical binding]; other site
656519005450	Q-loop/lid; other site
656519005451	ABC transporter signature motif; other site
656519005452	Walker B; other site
656519005453	D-loop; other site
656519005454	H-loop/switch region; other site
656519005455	Trehalose and maltose hydrolases (possible phosphorylases) [Carbohydrate transport and metabolism]; Region: ATH1; COG1554
656519005456	Glycosyl hydrolase family 65, N-terminal domain; Region: Glyco_hydro_65N; pfam03636
656519005457	Glycosyl hydrolase family 65 central catalytic domain; Region: Glyco_hydro_65m; pfam03632
656519005458	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
656519005459	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
656519005460	dimer interface [polypeptide binding]; other site
656519005461	conserved gate region; other site
656519005462	putative PBP binding loops; other site
656519005463	ABC-ATPase subunit interface; other site
656519005464	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
656519005465	dimer interface [polypeptide binding]; other site
656519005466	conserved gate region; other site
656519005467	putative PBP binding loops; other site
656519005468	ABC-ATPase subunit interface; other site
656519005469	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
656519005470	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
656519005471	Transcriptional regulators [Transcription]; Region: PurR; COG1609
656519005472	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
656519005473	DNA binding site [nucleotide binding]
656519005474	domain linker motif; other site
656519005475	Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267
656519005476	dimerization interface [polypeptide binding]; other site
656519005477	ligand binding site [chemical binding]; other site
656519005478	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
656519005479	The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995
656519005480	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444
656519005481	The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE).  The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257
656519005482	Walker A/P-loop; other site
656519005483	ATP binding site [chemical binding]; other site
656519005484	Q-loop/lid; other site
656519005485	ABC transporter signature motif; other site
656519005486	Walker B; other site
656519005487	D-loop; other site
656519005488	H-loop/switch region; other site
656519005489	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
656519005490	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic 'goose-type' lysozymes (GEWL).  LTs catalyze...; Region: LT_GEWL; cd00254
656519005491	N-acetyl-D-glucosamine binding site [chemical binding]; other site
656519005492	catalytic residue [active]
656519005493	dephospho-CoA kinase; Region: TIGR00152
656519005494	Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022
656519005495	CoA-binding site [chemical binding]; other site
656519005496	ATP-binding [chemical binding]; other site
656519005497	Methylglyoxal synthase catalyzes the enolization of dihydroxyacetone phosphate (DHAP) to produce methylglyoxal. The first part of the catalytic mechanism is believed to be similar to TIM (triosephosphate isomerase) in that both enzymes utilize DHAP to...; Region: MGS; cd01422
656519005498	active site
656519005499	dimer interfaces [polypeptide binding]; other site
656519005500	catalytic residues [active]
656519005501	formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103
656519005502	N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966
656519005503	DNA binding site [nucleotide binding]
656519005504	catalytic residue [active]
656519005505	H2TH interface [polypeptide binding]; other site
656519005506	putative catalytic residues [active]
656519005507	turnover-facilitating residue; other site
656519005508	intercalation triad [nucleotide binding]; other site
656519005509	8OG recognition residue [nucleotide binding]; other site
656519005510	putative reading head residues; other site
656519005511	Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831
656519005512	DNA polymerase I; Provisional; Region: PRK05755
656519005513	PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859
656519005514	active site
656519005515	metal binding site 1 [ion binding]; metal-binding site
656519005516	putative 5' ssDNA interaction site; other site
656519005517	metal binding site 3; metal-binding site
656519005518	metal binding site 2 [ion binding]; metal-binding site
656519005519	H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898
656519005520	putative DNA binding site [nucleotide binding]; other site
656519005521	putative metal binding site [ion binding]; other site
656519005522	DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012
656519005523	active site
656519005524	substrate binding site [chemical binding]; other site
656519005525	catalytic site [active]
656519005526	Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637
656519005527	active site
656519005528	DNA binding site [nucleotide binding]
656519005529	catalytic site [active]
656519005530	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
656519005531	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
656519005532	dimerization interface [polypeptide binding]; other site
656519005533	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
656519005534	dimer interface [polypeptide binding]; other site
656519005535	phosphorylation site [posttranslational modification]
656519005536	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
656519005537	ATP binding site [chemical binding]; other site
656519005538	Mg2+ binding site [ion binding]; other site
656519005539	G-X-G motif; other site
656519005540	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
656519005541	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
656519005542	active site
656519005543	phosphorylation site [posttranslational modification]
656519005544	intermolecular recognition site; other site
656519005545	dimerization interface [polypeptide binding]; other site
656519005546	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
656519005547	DNA binding site [nucleotide binding]
656519005548	Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149
656519005549	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
656519005550	protein binding site [polypeptide binding]; other site
656519005551	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
656519005552	catalytic core [active]
656519005553	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
656519005554	Domain of unknown function (DUF368); Region: DUF368; cl00893
656519005555	orotate phosphoribosyltransferase; Validated; Region: pyrE; PRK00455
656519005556	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
656519005557	active site
656519005558	dihydroorotate dehydrogenase (subfamily 1) family protein; Region: pyrD_sub1_fam; TIGR01037
656519005559	Dihydroorotate dehydrogenase (DHOD) class 1B FMN-binding domain. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine...; Region: DHOD_1B_like; cd04740
656519005560	heterodimer interface [polypeptide binding]; other site
656519005561	active site
656519005562	FMN binding site [chemical binding]; other site
656519005563	homodimer interface [polypeptide binding]; other site
656519005564	substrate binding site [chemical binding]; other site
656519005565	dihydroorotate dehydrogenase electron transfer subunit; Reviewed; Region: PRK00054
656519005566	FAD/NAD binding domain in the electron transfer subunit of dihydroorotate dehydrogenase. Dihydroorotate dehydrogenases (DHODs) catalyze the only redox reaction in pyrimidine de novo biosynthesis. They catalyze the oxidation of (S)-dihydroorotate to...; Region: DHOD_e_trans; cd06218
656519005567	FAD binding pocket [chemical binding]; other site
656519005568	FAD binding motif [chemical binding]; other site
656519005569	phosphate binding motif [ion binding]; other site
656519005570	beta-alpha-beta structure motif; other site
656519005571	NAD binding pocket [chemical binding]; other site
656519005572	Iron coordination center [ion binding]; other site
656519005573	Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase contains two...; Region: OMP_decarboxylase_like; cd04725
656519005574	active site
656519005575	dimer interface [polypeptide binding]; other site
656519005576	dihydroorotase; Validated; Region: pyrC; PRK09357
656519005577	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
656519005578	Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317
656519005579	active site
656519005580	aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856
656519005581	Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729
656519005582	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
656519005583	pyrimidine utilization transport protein G; Region: RutG; TIGR03616
656519005584	uracil-xanthine permease; Region: ncs2; TIGR00801
656519005585	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
656519005586	active site
656519005587	carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294
656519005588	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
656519005589	ATP-grasp domain; Region: ATP-grasp_4; cl03087
656519005590	Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787
656519005591	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
656519005592	ATP-grasp domain; Region: ATP-grasp_4; cl03087
656519005593	Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424
656519005594	IMP binding site; other site
656519005595	dimer interface [polypeptide binding]; other site
656519005596	interdomain contacts; other site
656519005597	partial ornithine binding site; other site
656519005598	carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564
656519005599	Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; cl03056
656519005600	Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744
656519005601	catalytic site [active]
656519005602	subunit interface [polypeptide binding]; other site
656519005603	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cl00159
656519005604	NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; cl11210
656519005605	[FeFe] hydrogenase, group A; Region: FeFe_hydrog_A; TIGR02512
656519005606	Iron only hydrogenase large subunit, C-terminal domain; Region: Fe_hyd_lg_C; pfam02906
656519005607	Iron hydrogenase small subunit; Region: Fe_hyd_SSU; cl03503
656519005608	NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit [Energy production and conversion]; Region: NuoF; COG1894
656519005609	Respiratory-chain NADH dehydrogenase 51 Kd subunit; Region: Complex1_51K; pfam01512
656519005610	NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; cl11211
656519005611	Respiratory-chain NADH dehydrogenase 24 Kd subunit; Region: Complex1_24kDa; pfam01257
656519005612	TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064
656519005613	putative dimer interface [polypeptide binding]; other site
656519005614	[2Fe-2S] cluster binding site [ion binding]; other site
656519005615	4Fe-4S dicluster domain; Region: Fer4_7; pfam12838
656519005616	4Fe-4S binding domain; Region: Fer4; cl02805
656519005617	Iron only hydrogenase large subunit, C-terminal domain; Region: Fe_hyd_lg_C; pfam02906
656519005618	Putative Fe-S cluster; Region: FeS; pfam04060
656519005619	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459
656519005620	Transcriptional regulator containing PAS, AAA-type ATPase, and DNA-binding domains [Transcription / Signal transduction mechanisms]; Region: RocR; COG3829
656519005621	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
656519005622	Walker A motif; other site
656519005623	ATP binding site [chemical binding]; other site
656519005624	Walker B motif; other site
656519005625	arginine finger; other site
656519005626	Predicted permease; Region: DUF318; pfam03773
656519005627	Serine-pyruvate aminotransferase/archaeal aspartate aminotransferase [Amino acid transport and metabolism]; Region: COG0075
656519005628	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
656519005629	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
656519005630	catalytic residue [active]
656519005631	Uncharacterized protein, DegV family COG1307; Region: DegV; cl00577
656519005632	Integrase core domain; Region: rve; cl01316
656519005633	DDE domain; Region: DDE_Tnp_IS240; pfam13610
656519005634	Integrase core domain; Region: rve_3; cl15866
656519005635	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box protein; Region: CSP_CDS; cd04458
656519005636	DNA-binding site [nucleotide binding]; DNA binding site
656519005637	RNA-binding motif; other site
656519005638	NADH dehydrogenase subunit 2; Provisional; Region: ND2; MTH00197
656519005639	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; cl14187
656519005640	NMT1-like family; Region: NMT1_2; cl15260
656519005641	NMT1-like family; Region: NMT1_2; cl15260
656519005642	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
656519005643	dimer interface [polypeptide binding]; other site
656519005644	conserved gate region; other site
656519005645	ABC-ATPase subunit interface; other site
656519005646	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
656519005647	dimer interface [polypeptide binding]; other site
656519005648	conserved gate region; other site
656519005649	ABC-ATPase subunit interface; other site
656519005650	OpuCA is a the ATP binding component of a bacterial solute transporter that serves a protective role to cells growing in a hyperosmolar environment.  ABC (ATP-binding cassette) transporter nucleotide-binding domain; ABC transporters are a large family of...; Region: ABC_OpuCA_Osmoprotection; cd03295
656519005651	glycine betaine/L-proline transport ATP binding subunit; Region: proV; TIGR01186
656519005652	Walker A/P-loop; other site
656519005653	ATP binding site [chemical binding]; other site
656519005654	Q-loop/lid; other site
656519005655	ABC transporter signature motif; other site
656519005656	Walker B; other site
656519005657	D-loop; other site
656519005658	H-loop/switch region; other site
656519005659	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354
656519005660	Phosphatidylglycerophosphatase A; a bacterial membrane-associated enzyme involved in lipid metabolism; Region: PgpA; cd06971
656519005661	tetramer interfaces [polypeptide binding]; other site
656519005662	binuclear metal-binding site [ion binding]; other site
656519005663	ADP-ribosylglycohydrolase; Region: ADP_ribosyl_GH; cl00614
656519005664	N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357
656519005665	Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cd00640
656519005666	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
656519005667	catalytic residue [active]
656519005668	Helix-turn-helix domains; Region: HTH; cl00088
656519005669	putative transposase OrfB; Reviewed; Region: PHA02517
656519005670	HTH-like domain; Region: HTH_21; pfam13276
656519005671	Integrase core domain; Region: rve; cl01316
656519005672	Integrase core domain; Region: rve_3; cl15866
656519005673	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
656519005674	PAS domain; Region: PAS_9; pfam13426
656519005675	putative active site [active]
656519005676	heme pocket [chemical binding]; other site
656519005677	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
656519005678	metal binding site [ion binding]; metal-binding site
656519005679	active site
656519005680	I-site; other site
656519005681	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
656519005682	Zn2+ binding site [ion binding]; other site
656519005683	Mg2+ binding site [ion binding]; other site
656519005684	Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826
656519005685	Helix-turn-helix domains; Region: HTH; cl00088
656519005686	Integrase core domain; Region: rve; cl01316
656519005687	Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826
656519005688	Helix-turn-helix domains; Region: HTH; cl00088
656519005689	Integrase core domain; Region: rve; cl01316
656519005690	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167
656519005691	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
656519005692	DNA-binding site [nucleotide binding]; DNA binding site
656519005693	Transposase, Mutator family; Region: Transposase_mut; pfam00872
656519005694	MULE transposase domain; Region: MULE; pfam10551
656519005695	Formiminotransferase-cyclodeaminase; Region: FTCD_C; cl01350
656519005696	5,10-methylene-tetrahydrofolate dehydrogenase/Methenyl tetrahydrofolate cyclohydrolase [Coenzyme metabolism]; Region: FolD; COG0190
656519005697	Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763
656519005698	NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080
656519005699	homodimer interface [polypeptide binding]; other site
656519005700	NADP binding site [chemical binding]; other site
656519005701	substrate binding site [chemical binding]; other site
656519005702	TolB amino-terminal domain; Region: TolB_N; cl00639
656519005703	TolB amino-terminal domain; Region: TolB_N; cl00639
656519005704	Type VIII secretion system (T8SS), CsgF protein; Region: CsgF; cl08082
656519005705	Curlin associated repeat; Region: Curlin_rpt; pfam07012
656519005706	Curlin associated repeat; Region: Curlin_rpt; pfam07012
656519005707	Curlin associated repeat; Region: Curlin_rpt; pfam07012
656519005708	Curlin associated repeat; Region: Curlin_rpt; pfam07012
656519005709	curlin minor subunit CsgB; Provisional; Region: csgB; PRK10101
656519005710	curlin minor subunit CsgB; Provisional; Region: csgB; PRK10101
656519005711	DNA-binding transcriptional activator of the SARP family [Signal transduction mechanisms]; Region: DnrI; COG3629
656519005712	Helix-turn-helix domains; Region: HTH; cl00088
656519005713	Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454
656519005714	Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872
656519005715	active site
656519005716	NAD binding site [chemical binding]; other site
656519005717	metal binding site [ion binding]; metal-binding site
656519005718	Protein of unknown function (DUF436); Region: DUF436; cl01860
656519005719	Predicted Fe-S oxidoreductase [General function prediction only]; Region: COG1242
656519005720	putative hydrolase; Validated; Region: PRK09248
656519005721	RNase P subunit p30; Region: RNase_P_p30; cl03389
656519005722	pyruvate kinase; Provisional; Region: PRK06354
656519005723	Pyruvate kinase (PK):  Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl09155
656519005724	domain interfaces; other site
656519005725	active site
656519005726	PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; cl01586
656519005727	Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to PFK family that includes ATP- and pyrophosphate (PPi)- dependent phosphofructokinases; Region: PFK; cl00204
656519005728	active site
656519005729	ADP/pyrophosphate binding site [chemical binding]; other site
656519005730	dimerization interface [polypeptide binding]; other site
656519005731	allosteric effector site; other site
656519005732	fructose-1,6-bisphosphate binding site; other site
656519005733	Tryptophan RNA-binding attenuator protein; Region: TrpBP; cl03437
656519005734	DNA polymerase III DnaE; Reviewed; Region: dnaE; PRK06826
656519005735	Bacterial DNA polymerase III alpha subunit; Region: DNA_pol3_alpha; pfam07733
656519005736	DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485
656519005737	generic binding surface I; other site
656519005738	generic binding surface II; other site
656519005739	NifU-like domain; Region: NifU; cl00484
656519005740	Protein of unknown function (DUF964); Region: DUF964; cl01483
656519005741	Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841
656519005742	active site
656519005743	metal binding site [ion binding]; metal-binding site
656519005744	homotetramer interface [polypeptide binding]; other site
656519005745	Uncharacterized conserved protein [Function unknown]; Region: COG2006
656519005746	Domain of unknown function (DUF362); Region: DUF362; pfam04015
656519005747	archaeoflavoprotein, MJ0208 family; Region: flavo_MJ0208; TIGR02700
656519005748	Zinc ribbon domain; Region: CxxC_CxxC_SSSS; cl00993
656519005749	putative regulatory protein, FmdB family; Region: CxxC_CxxC_SSSS; TIGR02605
656519005750	TRAM domain; Region: TRAM; cl01282
656519005751	SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265
656519005752	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
656519005753	S-adenosylmethionine binding site [chemical binding]; other site
656519005754	Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534
656519005755	MatE; Region: MatE; cl10513
656519005756	MatE; Region: MatE; cl10513
656519005757	CoA-disulfide reductase; Region: CoA_CoA_reduc; TIGR03385
656519005758	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
656519005759	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
656519005760	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125
656519005761	active site residue [active]
656519005762	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
656519005763	dimerization interface [polypeptide binding]; other site
656519005764	putative DNA binding site [nucleotide binding]; other site
656519005765	putative Zn2+ binding site [ion binding]; other site
656519005766	Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426
656519005767	putative active site [active]
656519005768	putative CoA binding site [chemical binding]; other site
656519005769	nudix motif; other site
656519005770	metal binding site [ion binding]; metal-binding site
656519005771	aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477
656519005772	GatB/GatE catalytic domain; Region: GatB_N; pfam02934
656519005773	GatB domain; Region: GatB_Yqey; cl11497
656519005774	Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154
656519005775	Amidase; Region: Amidase; cl11426
656519005776	Glu-tRNAGln amidotransferase C subunit; Region: Glu-tRNAGln; cl00495
656519005777	NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956
656519005778	NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114
656519005779	nucleotide binding pocket [chemical binding]; other site
656519005780	K-X-D-G motif; other site
656519005781	catalytic site [active]
656519005782	NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120
656519005783	NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119
656519005784	Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027
656519005785	Dimer interface [polypeptide binding]; other site
656519005786	ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073
656519005787	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
656519005788	Family description; Region: UvrD_C_2; cl15862
656519005789	GIY-YIG domain of hypothetical proteins from archaea and their bacterial homologs; Region: GIY-YIG_COG1833; cd10441
656519005790	GIY-YIG motif/motif A; other site
656519005791	putative active site [active]
656519005792	putative metal binding site [ion binding]; other site
656519005793	GTP-binding protein HflX; Region: GTP_HflX; TIGR03156
656519005794	GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167
656519005795	HflX GTPase family; Region: HflX; cd01878
656519005796	G1 box; other site
656519005797	GTP/Mg2+ binding site [chemical binding]; other site
656519005798	Switch I region; other site
656519005799	G2 box; other site
656519005800	G3 box; other site
656519005801	Switch II region; other site
656519005802	G4 box; other site
656519005803	G5 box; other site
656519005804	Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114
656519005805	Heat shock protein 33 (Hsp33):  Cytosolic protein that acts as a molecular chaperone under oxidative conditions.  In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498
656519005806	dimerization interface [polypeptide binding]; other site
656519005807	domain crossover interface; other site
656519005808	redox-dependent activation switch; other site
656519005809	Domain of unknown function (DUF4359); Region: DUF4359; pfam14271
656519005810	single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644
656519005811	DHH family; Region: DHH; pfam01368
656519005812	DHHA1 domain; Region: DHHA1; pfam02272
656519005813	CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641
656519005814	Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210
656519005815	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
656519005816	Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210
656519005817	Protein of unknown function (DUF456); Region: DUF456; cl01069
656519005818	Peroxiredoxin (PRX) family, AhpE-like subfamily; composed of proteins similar to Mycobacterium tuberculosis AhpE. AhpE is described as a 1-cys PRX because of the absence of a resolving cysteine. The structure and sequence of AhpE, however, show greater...; Region: PRX_AhpE_like; cd03018
656519005819	dimer interface [polypeptide binding]; other site
656519005820	catalytic triad [active]
656519005821	Uncharacterized FAD-dependent dehydrogenases [General function prediction only]; Region: COG2509
656519005822	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
656519005823	Helix-turn-helix domains; Region: HTH; cl00088
656519005824	GMP synthase; Reviewed; Region: guaA; PRK00074
656519005825	Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742
656519005826	AMP/PPi binding site [chemical binding]; other site
656519005827	candidate oxyanion hole; other site
656519005828	catalytic triad [active]
656519005829	potential glutamine specificity residues [chemical binding]; other site
656519005830	The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997
656519005831	ATP Binding subdomain [chemical binding]; other site
656519005832	Ligand Binding sites [chemical binding]; other site
656519005833	Dimerization subdomain; other site
656519005834	pyruvate phosphate dikinase; Provisional; Region: PRK09279
656519005835	Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326
656519005836	PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; cl01586
656519005837	Pyruvate kinase (PK):  Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl09155
656519005838	Kinase/pyrophosphorylase; Region: Kinase-PPPase; cl00780
656519005839	chaperonin GroEL; Reviewed; Region: groEL; PRK12849
656519005840	GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344
656519005841	ring oligomerisation interface [polypeptide binding]; other site
656519005842	ATP/Mg binding site [chemical binding]; other site
656519005843	stacking interactions; other site
656519005844	hinge regions; other site
656519005845	Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320
656519005846	oligomerisation interface [polypeptide binding]; other site
656519005847	mobile loop; other site
656519005848	roof hairpin; other site
656519005849	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
656519005850	Radical SAM superfamily; Region: Radical_SAM; pfam04055
656519005851	FeS/SAM binding site; other site
656519005852	PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989
656519005853	Protein of unknown function (DUF512); Region: DUF512; pfam04459
656519005854	UGMP family protein; Validated; Region: PRK09604
656519005855	Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl14000
656519005856	Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl14000
656519005857	Glycoprotease family; Region: Peptidase_M22; pfam00814
656519005858	Uncharacterized P-loop hydrolase UPF0079; Region: UPF0079; cl00520
656519005859	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
656519005860	pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880
656519005861	Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079
656519005862	gamma-glutamyl phosphate reductase; Region: proA; TIGR00407
656519005863	putative catalytic cysteine [active]
656519005864	gamma-glutamyl kinase; Provisional; Region: PRK05429
656519005865	AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242
656519005866	nucleotide binding site [chemical binding]; other site
656519005867	homotetrameric interface [polypeptide binding]; other site
656519005868	putative phosphate binding site [ion binding]; other site
656519005869	putative allosteric binding site; other site
656519005870	PUA domain; Region: PUA; cl00607
656519005871	PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cl00162
656519005872	HPr interaction site; other site
656519005873	glycerol kinase (GK) interaction site [polypeptide binding]; other site
656519005874	active site
656519005875	phosphorylation site [posttranslational modification]
656519005876	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
656519005877	catalytic loop [active]
656519005878	iron binding site [ion binding]; other site
656519005879	NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; cl11210
656519005880	[FeFe] hydrogenase, group A; Region: FeFe_hydrog_A; TIGR02512
656519005881	4Fe-4S binding domain; Region: Fer4; cl02805
656519005882	Iron only hydrogenase large subunit, C-terminal domain; Region: Fe_hyd_lg_C; pfam02906
656519005883	Iron hydrogenase small subunit; Region: Fe_hyd_SSU; cl03503
656519005884	Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980
656519005885	dimer interface [polypeptide binding]; other site
656519005886	[2Fe-2S] cluster binding site [ion binding]; other site
656519005887	NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit [Energy production and conversion]; Region: NuoF; COG1894
656519005888	Respiratory-chain NADH dehydrogenase 51 Kd subunit; Region: Complex1_51K; pfam01512
656519005889	SLBB domain; Region: SLBB; pfam10531
656519005890	NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; cl11211
656519005891	4Fe-4S binding domain; Region: Fer4; cl02805
656519005892	4Fe-4S dicluster domain; Region: Fer4_7; pfam12838
656519005893	4Fe-4S binding domain; Region: Fer4; cl02805
656519005894	Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980
656519005895	dimer interface [polypeptide binding]; other site
656519005896	[2Fe-2S] cluster binding site [ion binding]; other site
656519005897	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
656519005898	ATP binding site [chemical binding]; other site
656519005899	Mg2+ binding site [ion binding]; other site
656519005900	G-X-G motif; other site
656519005901	Respiratory-chain NADH dehydrogenase 24 Kd subunit; Region: Complex1_24kDa; pfam01257
656519005902	TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064
656519005903	putative dimer interface [polypeptide binding]; other site
656519005904	[2Fe-2S] cluster binding site [ion binding]; other site
656519005905	PHP family phosphoesterase with a Zn ribbon [General function prediction only]; Region: COG1379
656519005906	DRTGG domain; Region: DRTGG; cl12147
656519005907	[FeFe] hydrogenase, group B1/B3; Region: FeFe_hydrog_B1; TIGR04105
656519005908	4Fe-4S binding domain; Region: Fer4; cl02805
656519005909	Iron only hydrogenase large subunit, C-terminal domain; Region: Fe_hyd_lg_C; pfam02906
656519005910	Putative Fe-S cluster; Region: FeS; pfam04060
656519005911	Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581
656519005912	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
656519005913	ATP binding site [chemical binding]; other site
656519005914	Mg2+ binding site [ion binding]; other site
656519005915	G-X-G motif; other site
656519005916	PemK-like protein; Region: PemK; cl00995
656519005917	DbpA RNA binding domain; Region: DbpA; pfam03880
656519005918	DNA helicase, putative; Region: TIGR00376
656519005919	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
656519005920	Family description; Region: UvrD_C_2; cl15862
656519005921	Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557
656519005922	trimer interface [polypeptide binding]; other site
656519005923	active site
656519005924	YjeF-related protein N-terminus; Region: YjeF_N; cl00318
656519005925	B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171
656519005926	putative substrate binding site [chemical binding]; other site
656519005927	putative ATP binding site [chemical binding]; other site
656519005928	4'-phosphopantetheinyl transferase superfamily; Region: ACPS; cl00500
656519005929	glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331
656519005930	Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans).  The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714
656519005931	glutaminase active site [active]
656519005932	SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008
656519005933	dimer interface [polypeptide binding]; other site
656519005934	active site
656519005935	SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009
656519005936	dimer interface [polypeptide binding]; other site
656519005937	active site
656519005938	phosphoglucosamine mutase; Provisional; Region: glmM; PRK14316
656519005939	GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802
656519005940	active site
656519005941	substrate binding site [chemical binding]; other site
656519005942	metal binding site [ion binding]; metal-binding site
656519005943	50S ribosomal protein L25/general stress protein Ctc; Reviewed; Region: PRK05618
656519005944	TIGR00159 family protein; Region: TIGR00159
656519005945	DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457
656519005946	Pyruvate-formate lyase-activating enzyme [Posttranslational modification, protein turnover, chaperones]; Region: PflA; COG1180
656519005947	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
656519005948	FeS/SAM binding site; other site
656519005949	AMMECR1; Region: AMMECR1; cl00911
656519005950	The N-terminal domain, an extradiol dioxygenase class III subunit B-like domain, of unknown proteins containing a C-terminal AMMECR1 domain; Region: ED_3B_N_AMMECR1; cd07951
656519005951	Ribosomal protein S9/S16; Region: Ribosomal_S9; cl00334
656519005952	Ribosomal protein L13.  Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392
656519005953	23S rRNA interface [nucleotide binding]; other site
656519005954	L3 interface [polypeptide binding]; other site
656519005955	tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021
656519005956	PseudoU_synth_EcTruA: Pseudouridine synthase, Escherichia coli TruA like. This group consists of eukaryotic and bacterial pseudouridine synthases similar to E.  coli TruA, Pseudomonas aeruginosa truA and human pseudouridine synthase-like 1 (PUSL1); Region: PseudoU_synth_EcTruA; cd02570
656519005957	dimerization interface 3.5A [polypeptide binding]; other site
656519005958	active site
656519005959	Cobalt transport protein; Region: CbiQ; cl00463
656519005960	cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13637
656519005961	Domain I of the ABC component of a cobalt transport family found in bacteria, archaea, and eukaryota.  The transition metal cobalt is an essential component of many enzymes and must be transported into cells in appropriate amounts when needed.  This ABC...; Region: ABC_cobalt_CbiO_domain1; cd03225
656519005962	Walker A/P-loop; other site
656519005963	ATP binding site [chemical binding]; other site
656519005964	Q-loop/lid; other site
656519005965	ABC transporter signature motif; other site
656519005966	Walker B; other site
656519005967	D-loop; other site
656519005968	H-loop/switch region; other site
656519005969	cobalt transporter ATP-binding subunit; Provisional; Region: PRK13633
656519005970	Domain I of the ABC component of a cobalt transport family found in bacteria, archaea, and eukaryota.  The transition metal cobalt is an essential component of many enzymes and must be transported into cells in appropriate amounts when needed.  This ABC...; Region: ABC_cobalt_CbiO_domain1; cd03225
656519005971	Walker A/P-loop; other site
656519005972	ATP binding site [chemical binding]; other site
656519005973	Q-loop/lid; other site
656519005974	ABC transporter signature motif; other site
656519005975	Walker B; other site
656519005976	D-loop; other site
656519005977	H-loop/switch region; other site
656519005978	Ribosomal protein L17; Region: Ribosomal_L17; cl00356
656519005979	DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182
656519005980	N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928
656519005981	alphaNTD homodimer interface [polypeptide binding]; other site
656519005982	alphaNTD - beta interaction site [polypeptide binding]; other site
656519005983	alphaNTD - beta' interaction site [polypeptide binding]; other site
656519005984	Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; cl11613
656519005985	30S ribosomal protein S4; Validated; Region: rpsD; PRK05327
656519005986	Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163
656519005987	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
656519005988	RNA binding surface [nucleotide binding]; other site
656519005989	Ribosomal protein S11; Region: Ribosomal_S11; cl00332
656519005990	Ribosomal protein S13/S18; Region: Ribosomal_S13; cl00331
656519005991	Ribosomal protein S13 [Translation, ribosomal structure and biogenesis]; Region: RpsM; COG0099
656519005992	Ribosomal protein L36; Region: Ribosomal_L36; cl00380
656519005993	S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451
656519005994	rRNA binding site [nucleotide binding]; other site
656519005995	predicted 30S ribosome binding site; other site
656519005996	Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086
656519005997	active site
656519005998	adenylate kinase; Reviewed; Region: adk; PRK00279
656519005999	Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428
656519006000	AMP-binding site [chemical binding]; other site
656519006001	ATP-AMP (Ap5A)-binding site [chemical binding]; other site
656519006002	preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204
656519006003	SecY translocase; Region: SecY; pfam00344
656519006004	Ribosomal protein L18e/L15; Region: Ribosomal_L18e; cl12022
656519006005	30S ribosomal protein S5; Validated; Region: rpsE; PRK00550
656519006006	Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333
656519006007	Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719
656519006008	Ribosomal L18/L5e:  L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432
656519006009	23S rRNA interface [nucleotide binding]; other site
656519006010	L21e interface [polypeptide binding]; other site
656519006011	5S rRNA interface [nucleotide binding]; other site
656519006012	L27 interface [polypeptide binding]; other site
656519006013	L5 interface [polypeptide binding]; other site
656519006014	50S ribosomal protein L6; Validated; Region: rplF; PRK05498
656519006015	Ribosomal protein L6; Region: Ribosomal_L6; pfam00347
656519006016	Ribosomal protein L6; Region: Ribosomal_L6; pfam00347
656519006017	Ribosomal protein S8; Region: Ribosomal_S8; cl00330
656519006018	Ribosomal protein S14p/S29e; Region: Ribosomal_S14; cl00355
656519006019	50S ribosomal protein L5; Validated; Region: rplE; PRK00010
656519006020	Ribosomal protein L5; Region: Ribosomal_L5; pfam00281
656519006021	ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673
656519006022	50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004
656519006023	KOW motif; Region: KOW; cl00354
656519006024	Ribosomal protein L14p/L23e; Region: Ribosomal_L14; cl00328
656519006025	Ribosomal protein S17; Region: Ribosomal_S17; cl00351
656519006026	Ribosomal L29 protein/HIP.  L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals.  L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427
656519006027	putative translocon interaction site; other site
656519006028	23S rRNA interface [nucleotide binding]; other site
656519006029	signal recognition particle (SRP54) interaction site; other site
656519006030	L23 interface [polypeptide binding]; other site
656519006031	trigger factor interaction site; other site
656519006032	Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433
656519006033	23S rRNA interface [nucleotide binding]; other site
656519006034	5S rRNA interface [nucleotide binding]; other site
656519006035	putative antibiotic binding site [chemical binding]; other site
656519006036	L25 interface [polypeptide binding]; other site
656519006037	L27 interface [polypeptide binding]; other site
656519006038	ribosomal protein S3, bacterial type; Region: rpsC_bact; TIGR01009
656519006039	K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3  is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel.  The KH...; Region: 30S_S3_KH; cd02412
656519006040	G-X-X-G motif; other site
656519006041	Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189
656519006042	Ribosomal protein L22/L17e.  L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit.  It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336
656519006043	putative translocon binding site; other site
656519006044	protein-rRNA interface [nucleotide binding]; other site
656519006045	Ribosomal protein S19; Region: Ribosomal_S19; cl00350
656519006046	50S ribosomal protein L2; Validated; Region: rplB; PRK09374
656519006047	Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181
656519006048	Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947
656519006049	Ribosomal protein L23; Region: Ribosomal_L23; cl00326
656519006050	Ribosomal protein L4/L1 family; Region: Ribosomal_L4; cl00325
656519006051	Ribosomal protein L3; Region: Ribosomal_L3; cl00324
656519006052	Ribosomal protein S10p/S20e; Region: Ribosomal_S10; cl00314
656519006053	elongation factor Tu; Reviewed; Region: PRK00049
656519006054	Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884
656519006055	G1 box; other site
656519006056	GEF interaction site [polypeptide binding]; other site
656519006057	GTP/Mg2+ binding site [chemical binding]; other site
656519006058	Switch I region; other site
656519006059	G2 box; other site
656519006060	G3 box; other site
656519006061	Switch II region; other site
656519006062	G4 box; other site
656519006063	G5 box; other site
656519006064	EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697
656519006065	Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707
656519006066	Antibiotic Binding Site [chemical binding]; other site
656519006067	elongation factor G; Reviewed; Region: PRK00007
656519006068	Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886
656519006069	G1 box; other site
656519006070	putative GEF interaction site [polypeptide binding]; other site
656519006071	GTP/Mg2+ binding site [chemical binding]; other site
656519006072	Switch I region; other site
656519006073	G2 box; other site
656519006074	G3 box; other site
656519006075	Switch II region; other site
656519006076	G4 box; other site
656519006077	G5 box; other site
656519006078	EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088
656519006079	EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434
656519006080	EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G.  Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713
656519006081	Ribosomal protein S7p/S5e; Region: Ribosomal_S7; cl00313
656519006082	S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368
656519006083	S17 interaction site [polypeptide binding]; other site
656519006084	S8 interaction site; other site
656519006085	16S rRNA interaction site [nucleotide binding]; other site
656519006086	streptomycin interaction site [chemical binding]; other site
656519006087	23S rRNA interaction site [nucleotide binding]; other site
656519006088	aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site
656519006089	Ribosomal protein L7Ae/L30e/S12e/Gadd45 family; Region: Ribosomal_L7Ae; cl00600
656519006090	DNA-directed RNA polymerase subunit beta'; Provisional; Region: PRK00566
656519006091	RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997
656519006092	RNA polymerase Rpb1, domain 2; Region: RNA_pol_Rpb1_2; cl11591
656519006093	RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983
656519006094	RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000
656519006095	Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429
656519006096	Rpb1 - Rpb6 interaction site [polypeptide binding]; other site
656519006097	Apocytochrome F, C-terminal; Region: Apocytochr_F_C; cl03168
656519006098	Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655
656519006099	DNA binding site [nucleotide binding]
656519006100	Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site
656519006101	DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405
656519006102	RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561
656519006103	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653
656519006104	RPB1 interaction site [polypeptide binding]; other site
656519006105	RPB10 interaction site [polypeptide binding]; other site
656519006106	RPB11 interaction site [polypeptide binding]; other site
656519006107	RPB3 interaction site [polypeptide binding]; other site
656519006108	RPB12 interaction site [polypeptide binding]; other site
656519006109	Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387
656519006110	L11 interface [polypeptide binding]; other site
656519006111	putative EF-Tu interaction site [polypeptide binding]; other site
656519006112	putative EF-G interaction site [polypeptide binding]; other site
656519006113	Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797
656519006114	23S rRNA interface [nucleotide binding]; other site
656519006115	Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site
656519006116	Ribosomal protein L1.  The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA.  In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403
656519006117	mRNA/rRNA interface [nucleotide binding]; other site
656519006118	50S ribosomal protein L11; Validated; Region: rplK; PRK00140
656519006119	Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349
656519006120	23S rRNA interface [nucleotide binding]; other site
656519006121	L7/L12 interface [polypeptide binding]; other site
656519006122	putative thiostrepton binding site; other site
656519006123	L25 interface [polypeptide binding]; other site
656519006124	transcription antitermination protein NusG; Validated; Region: nusG; PRK05609
656519006125	Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891
656519006126	putative homodimer interface [polypeptide binding]; other site
656519006127	KOW motif; Region: KOW; cl00354
656519006128	SecE/Sec61-gamma subunits of protein translocation complex; Region: SecE; cl00481
656519006129	Ribosomal protein L33; Region: Ribosomal_L33; cl00383
656519006130	elongation factor Tu; Reviewed; Region: PRK00049
656519006131	Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884
656519006132	G1 box; other site
656519006133	GEF interaction site [polypeptide binding]; other site
656519006134	GTP/Mg2+ binding site [chemical binding]; other site
656519006135	Switch I region; other site
656519006136	G2 box; other site
656519006137	G3 box; other site
656519006138	Switch II region; other site
656519006139	G4 box; other site
656519006140	G5 box; other site
656519006141	EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697
656519006142	Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707
656519006143	Antibiotic Binding Site [chemical binding]; other site
656519006144	RNA polymerase factor sigma-70; Validated; Region: PRK08295
656519006145	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
656519006146	Helix-turn-helix domains; Region: HTH; cl00088
656519006147	rRNA methylase, putative, group 3; Region: rRNA_methyl_3; TIGR00186
656519006148	RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; cl06870
656519006149	SpoU rRNA Methylase family; Region: SpoU_methylase; cl00362
656519006150	Thymidylate synthase complementing protein; Region: Thy1; cl03630
656519006151	cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260
656519006152	catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672
656519006153	active site
656519006154	HIGH motif; other site
656519006155	catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672
656519006156	KMSKS motif; other site
656519006157	Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020
656519006158	tRNA binding surface [nucleotide binding]; other site
656519006159	anticodon binding site; other site
656519006160	glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406
656519006161	catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808
656519006162	active site
656519006163	HIGH motif; other site
656519006164	catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808
656519006165	active site
656519006166	KMSKS motif; other site
656519006167	FOG: CBS domain [General function prediction only]; Region: COG0517
656519006168	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354
656519006169	HutP; Region: HutP; cl07944
656519006170	MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554
656519006171	homotrimer interaction site [polypeptide binding]; other site
656519006172	zinc binding site [ion binding]; other site
656519006173	CDP-binding sites; other site
656519006174	CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516
656519006175	substrate binding site; other site
656519006176	dimer interface; other site
656519006177	Integral membrane protein (PIN domain superfamily) [General function prediction only]; Region: COG4956
656519006178	PIN domain of Thermus Thermophilus Hb8, uncharacterized Bacillus subtilis YacL, and other bacterial homologs; Region: PIN_YacL; cd09877
656519006179	putative active site [active]
656519006180	CarD-like/TRCF domain; Region: CarD_CdnL_TRCF; cl00588
656519006181	DNA integrity scanning protein DisA; Provisional; Region: PRK13482
656519006182	DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457
656519006183	DisA bacterial checkpoint controller linker region; Region: DisA-linker; pfam10635
656519006184	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786
656519006185	Clp protease ATP binding subunit; Region: clpC; CHL00095
656519006186	Clp amino terminal domain; Region: Clp_N; pfam02861
656519006187	Clp amino terminal domain; Region: Clp_N; pfam02861
656519006188	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
656519006189	Walker A motif; other site
656519006190	ATP binding site [chemical binding]; other site
656519006191	Walker B motif; other site
656519006192	arginine finger; other site
656519006193	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
656519006194	Walker A motif; other site
656519006195	ATP binding site [chemical binding]; other site
656519006196	Walker B motif; other site
656519006197	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; cl11083
656519006198	ATP:guanido phosphotransferase; Provisional; Region: PRK01059
656519006199	Phosphagen (guanidino) kinases found in bacteria; Region: bacterial_phosphagen_kinase; cd07930
656519006200	ADP binding site [chemical binding]; other site
656519006201	phosphagen binding site; other site
656519006202	substrate specificity loop; other site
656519006203	Modulator of heat shock repressor CtsR, McsA [Signal transduction    mechanisms]; Region: COG3880
656519006204	UvrB/uvrC motif; Region: UVR; pfam02151
656519006205	Firmicute transcriptional repressor of class III stress genes (CtsR); Region: CtsR; cl01850
656519006206	Uncharacterized protein family UPF0047; Region: UPF0047; cl00439
656519006207	lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484
656519006208	LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322
656519006209	dimer interface [polypeptide binding]; other site
656519006210	putative anticodon binding site; other site
656519006211	Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775
656519006212	motif 1; other site
656519006213	active site
656519006214	motif 2; other site
656519006215	motif 3; other site
656519006216	transcription elongation factor GreA; Reviewed; Region: greA; PRK00226
656519006217	Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449
656519006218	Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272
656519006219	putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737
656519006220	Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801
656519006221	FMN binding site [chemical binding]; other site
656519006222	active site
656519006223	catalytic residues [active]
656519006224	substrate binding site [chemical binding]; other site
656519006225	Type III pantothenate kinase; Region: Pan_kinase; cl09130
656519006226	Dioxygenases related to 2-nitropropane dioxygenase [General function prediction only]; Region: COG2070
656519006227	2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730
656519006228	FMN binding site [chemical binding]; other site
656519006229	substrate binding site [chemical binding]; other site
656519006230	putative catalytic residue [active]
656519006231	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
656519006232	Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057
656519006233	Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340
656519006234	ECF-type riboflavin transporter, S component; Region: ECF-ribofla_trS; cl01942
656519006235	Formate--tetrahydrofolate ligase; Region: FTHFS; pfam01268
656519006236	Formyltetrahydrofolate synthetase (FTHFS) catalyzes the ATP-dependent activation of formate ion via its addition to the N10 position of tetrahydrofolate. FTHFS is a highly expressed key enzyme in both the Wood-Ljungdahl pathway of autotrophic CO2...; Region: FTHFS; cd00477
656519006237	Potassium binding sites [ion binding]; other site
656519006238	Cesium cation binding sites [ion binding]; other site
656519006239	Uncharacterized protein family (UPF0014); Region: UPF0014; cl00424
656519006240	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
656519006241	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
656519006242	Walker A/P-loop; other site
656519006243	ATP binding site [chemical binding]; other site
656519006244	Q-loop/lid; other site
656519006245	ABC transporter signature motif; other site
656519006246	Walker B; other site
656519006247	D-loop; other site
656519006248	H-loop/switch region; other site
656519006249	FtsH Extracellular; Region: FtsH_ext; pfam06480
656519006250	ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241
656519006251	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
656519006252	Walker A motif; other site
656519006253	ATP binding site [chemical binding]; other site
656519006254	Walker B motif; other site
656519006255	arginine finger; other site
656519006256	Peptidase family M41; Region: Peptidase_M41; pfam01434
656519006257	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
656519006258	active site
656519006259	N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992
656519006260	Ligand Binding Site [chemical binding]; other site
656519006261	B3/4 domain; Region: B3_4; cl11458
656519006262	Ppx/GppA phosphatase family; Region: Ppx-GppA; cl15449
656519006263	Protein of unknown function (DUF501); Region: DUF501; cl00652
656519006264	hypothetical protein; Provisional; Region: PRK08582
656519006265	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
656519006266	RNA binding site [nucleotide binding]; other site
656519006267	Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826
656519006268	Helix-turn-helix domains; Region: HTH; cl00088
656519006269	Integrase core domain; Region: rve; cl01316
656519006270	Transcriptional accessory protein [Transcription]; Region: Tex; COG2183
656519006271	Tex-like protein N-terminal domain; Region: Tex_N; pfam09371
656519006272	Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination.  HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD includes...; Region: RuvC_resolvase; cl00243
656519006273	S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685
656519006274	RNA binding site [nucleotide binding]; other site
656519006275	Septum formation initiator; Region: DivIC; cl11433
656519006276	Protein of unknown function (DUF964); Region: DUF964; cl01483
656519006277	Anion-transporting ATPase; Region: ArsA_ATPase; pfam02374
656519006278	ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035
656519006279	P loop; other site
656519006280	Nucleotide binding site [chemical binding]; other site
656519006281	DTAP/Switch II; other site
656519006282	Switch I; other site
656519006283	Anion-transporting ATPase; Region: ArsA_ATPase; pfam02374
656519006284	ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035
656519006285	P loop; other site
656519006286	Nucleotide binding site [chemical binding]; other site
656519006287	DTAP/Switch II; other site
656519006288	Switch I; other site
656519006289	Arsenical resistance operon trans-acting repressor ArsD; Region: ArsD; pfam06953
656519006290	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
656519006291	dimerization interface [polypeptide binding]; other site
656519006292	putative DNA binding site [nucleotide binding]; other site
656519006293	putative Zn2+ binding site [ion binding]; other site
656519006294	Peptidase C26; Region: Peptidase_C26; pfam07722
656519006295	Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745
656519006296	catalytic triad [active]
656519006297	glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650
656519006298	The N-terminal ATPase domain of the maltose transporter, MalK.  ATP binding cassette (ABC) proteins function from bacteria to human, mediating the translocation of substances into and out of cells or organelles.  ABC transporters contain two...; Region: ABC_MalK_N; cd03301
656519006299	Walker A/P-loop; other site
656519006300	ATP binding site [chemical binding]; other site
656519006301	Q-loop/lid; other site
656519006302	ABC transporter signature motif; other site
656519006303	Walker B; other site
656519006304	D-loop; other site
656519006305	H-loop/switch region; other site
656519006306	TOBE domain; Region: TOBE_2; cl01440
656519006307	Transcriptional regulators [Transcription]; Region: PurR; COG1609
656519006308	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
656519006309	DNA binding site [nucleotide binding]
656519006310	domain linker motif; other site
656519006311	Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267
656519006312	dimerization interface [polypeptide binding]; other site
656519006313	ligand binding site [chemical binding]; other site
656519006314	beta-phosphoglucomutase; Region: bPGM; TIGR01990
656519006315	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
656519006316	motif II; other site
656519006317	2'-5' RNA ligase superfamily; Region: 2_5_RNA_ligase2; pfam13563
656519006318	ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120
656519006319	ABC transporters, involved in the uptake of siderophores, heme, and vitamin B12, are widely conserved in bacteria and archaea.  Only very few species lack representatives of the siderophore family transporters. The E. coli BtuCD protein is an ABC...; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214
656519006320	Walker A/P-loop; other site
656519006321	ATP binding site [chemical binding]; other site
656519006322	Q-loop/lid; other site
656519006323	ABC transporter signature motif; other site
656519006324	Walker B; other site
656519006325	D-loop; other site
656519006326	H-loop/switch region; other site
656519006327	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
656519006328	ABC-ATPase subunit  interface; other site
656519006329	dimer interface [polypeptide binding]; other site
656519006330	putative PBP binding regions; other site
656519006331	Protein of unknown function (DUF1015); Region: DUF1015; cl01715
656519006332	D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK13581
656519006333	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
656519006334	C-terminal ACT (regulatory) domain of D-3-phosphoglycerate dehydrogenase (3PGDH); Region: ACT_3PGDH-xct; cd04902
656519006335	putative L-serine binding site [chemical binding]; other site
656519006336	Serine-pyruvate aminotransferase/archaeal aspartate aminotransferase [Amino acid transport and metabolism]; Region: COG0075
656519006337	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
656519006338	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
656519006339	catalytic residue [active]
656519006340	D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686
656519006341	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009
656519006342	Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; cl06814
656519006343	nucleoside triphosphate pyrophosphohydrolase; Reviewed; Region: mazG; PRK09562
656519006344	MazG nucleotide pyrophosphohydrolase domain; Region: MazG; cl00345
656519006345	stage V sporulation protein B; Region: spore_V_B; TIGR02900
656519006346	MatE; Region: MatE; cl10513
656519006347	MatE; Region: MatE; cl10513
656519006348	Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197
656519006349	CarD-like/TRCF domain; Region: CarD_CdnL_TRCF; cl00588
656519006350	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
656519006351	ATP binding site [chemical binding]; other site
656519006352	putative Mg++ binding site [ion binding]; other site
656519006353	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
656519006354	nucleotide binding region [chemical binding]; other site
656519006355	ATP-binding site [chemical binding]; other site
656519006356	TRCF domain; Region: TRCF; cl04088
656519006357	Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462
656519006358	putative active site [active]
656519006359	catalytic residue [active]
656519006360	Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495
656519006361	ribosomal protein L25, Ctc-form; Region: ctc_TL5; TIGR00731
656519006362	5S rRNA interface [nucleotide binding]; other site
656519006363	CTC domain interface [polypeptide binding]; other site
656519006364	L16 interface [polypeptide binding]; other site
656519006365	ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259
656519006366	N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793
656519006367	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
656519006368	active site
656519006369	bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14354
656519006370	N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540
656519006371	Substrate binding site; other site
656519006372	Mg++ binding site; other site
656519006373	N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353
656519006374	active site
656519006375	substrate binding site [chemical binding]; other site
656519006376	CoA binding site [chemical binding]; other site
656519006377	SpoVG; Region: SpoVG; cl00915
656519006378	AIR synthase (PurM) related protein, subgroup 1 of unknown function. The family of PurM related proteins includes Hydrogen expression/formation protein HypE, AIR synthases, FGAM synthase and Selenophosphate synthetase (SelD). They all contain two...; Region: PurM-like1; cd06061
656519006379	Hydrogenase maturation factor [Posttranslational modification, protein turnover, chaperones]; Region: HypE; COG0309
656519006380	dimerization interface [polypeptide binding]; other site
656519006381	putative ATP binding site [chemical binding]; other site
656519006382	ECF-type riboflavin transporter, S component; Region: ECF-ribofla_trS; cl01942
656519006383	glutamine synthetase, type I; Region: GlnA; TIGR00653
656519006384	Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951
656519006385	Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120
656519006386	Helix-Turn-Helix DNA binding domain of GlnR-like transcription regulators; Region: HTH_GlnR-like; cd01105
656519006387	DNA binding residues [nucleotide binding]
656519006388	putative dimer interface [polypeptide binding]; other site
656519006389	4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: ipk; PRK00128
656519006390	GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288
656519006391	GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544
656519006392	ECF-type riboflavin transporter, S component; Region: ECF-ribofla_trS; cl01942
656519006393	PspC domain; Region: PspC; cl00864
656519006394	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
656519006395	ABC transporter transmembrane region; Region: ABC_membrane; cl00549
656519006396	MsbA is an essential ABC transporter, closely related to eukaryotic MDR proteins.  ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars, ions, peptides, and more complex organic...; Region: ABCC_MsbA; cd03251
656519006397	Walker A/P-loop; other site
656519006398	ATP binding site [chemical binding]; other site
656519006399	Q-loop/lid; other site
656519006400	ABC transporter signature motif; other site
656519006401	Walker B; other site
656519006402	D-loop; other site
656519006403	H-loop/switch region; other site
656519006404	phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135
656519006405	PhoU domain; Region: PhoU; pfam01895
656519006406	PhoU domain; Region: PhoU; pfam01895
656519006407	phosphate transporter ATP-binding protein; Provisional; Region: PRK14240
656519006408	Phosphate uptake is of fundamental importance in the cell physiology of bacteria because phosphate is required as a nutrient.  The Pst system of E. coli comprises four distinct subunits encoded by the pstS, pstA, pstB, and pstC genes.  The PstS protein...; Region: ABC_PstB_phosphate_transporter; cd03260
656519006409	Walker A/P-loop; other site
656519006410	ATP binding site [chemical binding]; other site
656519006411	Q-loop/lid; other site
656519006412	ABC transporter signature motif; other site
656519006413	Walker B; other site
656519006414	D-loop; other site
656519006415	H-loop/switch region; other site
656519006416	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
656519006417	dimer interface [polypeptide binding]; other site
656519006418	conserved gate region; other site
656519006419	putative PBP binding loops; other site
656519006420	ABC-ATPase subunit interface; other site
656519006421	phosphate ABC transporter, permease protein PstC; Region: phosphate_pstC; TIGR02138
656519006422	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
656519006423	dimer interface [polypeptide binding]; other site
656519006424	conserved gate region; other site
656519006425	putative PBP binding loops; other site
656519006426	ABC-ATPase subunit interface; other site
656519006427	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427
656519006428	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
656519006429	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
656519006430	dimerization interface [polypeptide binding]; other site
656519006431	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
656519006432	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
656519006433	putative active site [active]
656519006434	heme pocket [chemical binding]; other site
656519006435	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
656519006436	dimer interface [polypeptide binding]; other site
656519006437	phosphorylation site [posttranslational modification]
656519006438	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
656519006439	ATP binding site [chemical binding]; other site
656519006440	Mg2+ binding site [ion binding]; other site
656519006441	G-X-G motif; other site
656519006442	phosphate regulon transcriptional regulatory protein PhoB; Region: PhoB; TIGR02154
656519006443	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
656519006444	active site
656519006445	phosphorylation site [posttranslational modification]
656519006446	intermolecular recognition site; other site
656519006447	dimerization interface [polypeptide binding]; other site
656519006448	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
656519006449	DNA binding site [nucleotide binding]
656519006450	Na+/phosphate symporter [Inorganic ion transport and metabolism]; Region: NptA; COG1283
656519006451	Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690
656519006452	Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690
656519006453	PhoU domain; Region: PhoU; pfam01895
656519006454	PhoU domain; Region: PhoU; pfam01895
656519006455	Protein of unknown function (DUF1021); Region: DUF1021; cl01852
656519006456	Protein of unknown function (DUF458); Region: DUF458; cl00861
656519006457	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
656519006458	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
656519006459	TatD like proteins;  E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310
656519006460	active site
656519006461	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
656519006462	cysteine desulfurase DndA; Region: DNA_S_dndA; TIGR03235
656519006463	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
656519006464	catalytic residue [active]
656519006465	thiamine biosynthesis protein ThiI; Provisional; Region: PRK01565
656519006466	THUMP domain; Region: THUMP; cl12076
656519006467	ThiI is required for thiazole synthesis in the thiamine biosynthesis pathway. It belongs to the Adenosine Nucleotide Hydrolysis suoerfamily and predicted to bind to Adenosine nucleotide; Region: ThiI; cd01712
656519006468	Ligand Binding Site [chemical binding]; other site
656519006469	phosphoribosylformylglycinamidine synthase, clade II; Region: FGAM-synthase; TIGR01857
656519006470	AIR (aminoimidazole ribonucleotide) synthase related protein. This family includes Hydrogen expression/formation protein HypE, AIR synthases, FGAM (formylglycinamidine ribonucleotide) synthase and Selenophosphate synthetase (SelD). The N-terminal domain...; Region: PurM-like; cl10019
656519006471	PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203
656519006472	dimerization interface [polypeptide binding]; other site
656519006473	ATP binding site [chemical binding]; other site
656519006474	PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204
656519006475	dimerization interface [polypeptide binding]; other site
656519006476	ATP binding site [chemical binding]; other site
656519006477	Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740
656519006478	putative active site [active]
656519006479	catalytic triad [active]
656519006480	Transcriptional regulator [Transcription]; Region: LysR; COG0583
656519006481	Helix-turn-helix domains; Region: HTH; cl00088
656519006482	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
656519006483	dimerization interface [polypeptide binding]; other site
656519006484	ParB-like nuclease domain; Region: ParBc; cl02129
656519006485	UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13905
656519006486	FAD binding domain; Region: FAD_binding_4; pfam01565
656519006487	UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873
656519006488	The GIY-YIG domain of uncharacterized protein family UPF0213 related to structure-specific endonuclease SLX1; Region: GIY-YIG_UPF0213; cd10456
656519006489	GIY-YIG motif/motif A; other site
656519006490	putative active site [active]
656519006491	putative metal binding site [ion binding]; other site
656519006492	Uncharacterized family of ferritin-like proteins found in archaea and bacteria; Region: Ferritin_like_AB; cd01045
656519006493	diiron binding motif [ion binding]; other site
656519006494	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
656519006495	Helix-turn-helix domains; Region: HTH; cl00088
656519006496	S-layer homology domain; Region: SLH; pfam00395
656519006497	Type I phosphodiesterase / nucleotide pyrophosphatase; Region: Phosphodiest; pfam01663
656519006498	Protein of unknown function (DUF1232); Region: DUF1232; cl01318
656519006499	NMT1-like family; Region: NMT1_2; cl15260
656519006500	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
656519006501	dimer interface [polypeptide binding]; other site
656519006502	conserved gate region; other site
656519006503	ABC-ATPase subunit interface; other site
656519006504	DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153
656519006505	MetN (also known as YusC) is an ABC-type transporter encoded by metN of the metNPQ operon in Bacillus subtilis that is involved in methionine transport.  Other members of this system include the MetP permease and  the MetQ substrate binding protein.  ABC...; Region: ABC_MetN_methionine_transporter; cd03258
656519006506	Walker A/P-loop; other site
656519006507	ATP binding site [chemical binding]; other site
656519006508	Q-loop/lid; other site
656519006509	ABC transporter signature motif; other site
656519006510	Walker B; other site
656519006511	D-loop; other site
656519006512	H-loop/switch region; other site
656519006513	NIL domain; Region: NIL; cl09633
656519006514	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
656519006515	dimerization interface [polypeptide binding]; other site
656519006516	putative DNA binding site [nucleotide binding]; other site
656519006517	putative Zn2+ binding site [ion binding]; other site
656519006518	Predicted permease; Region: DUF318; pfam03773
656519006519	Predicted permeases [General function prediction only]; Region: COG0701
656519006520	Predicted permeases [General function prediction only]; Region: COG0701
656519006521	Predicted permease; Region: DUF318; pfam03773
656519006522	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
656519006523	Fe2+ transport system protein B [Inorganic ion transport and metabolism]; Region: FeoB; COG0370
656519006524	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
656519006525	G1 box; other site
656519006526	GTP/Mg2+ binding site [chemical binding]; other site
656519006527	G2 box; other site
656519006528	Switch I region; other site
656519006529	G3 box; other site
656519006530	Switch II region; other site
656519006531	G4 box; other site
656519006532	G5 box; other site
656519006533	Nucleoside recognition; Region: Gate; cl00486
656519006534	Nucleoside recognition; Region: Gate; cl00486
656519006535	FeoA domain; Region: FeoA; cl00838
656519006536	Uncharacterized protein family (UPF0104); Region: UPF0104; cl04219
656519006537	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl15754
656519006538	S-adenosylmethionine binding site [chemical binding]; other site
656519006539	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
656519006540	bifunctional aconitate hydratase 2/2-methylisocitrate dehydratase; Validated; Region: PRK09238
656519006541	Aconitase swivel domain. Aconitase (aconitate hydratase) catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle. This is the aconitase swivel domain, which undergoes swivelling conformational change in the enzyme...; Region: Aconitase_swivel; cl00215
656519006542	substrate binding site [chemical binding]; other site
656519006543	Aconitase catalytic domain; Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: Aconitase; cl00285
656519006544	substrate binding site [chemical binding]; other site
656519006545	ligand binding site [chemical binding]; other site
656519006546	tartrate dehydrogenase; Provisional; Region: PRK08194
656519006547	Isocitrate/isopropylmalate dehydrogenase; Region: Iso_dh; cl00445
656519006548	Predicted metal-dependent phosphoesterases (PHP family) [General function prediction only]; Region: COG0613
656519006549	YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259
656519006550	putative active site [active]
656519006551	Transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this domain superfamily was previously known as DUF156; Region: CsoR-like_DUF156; cd10148
656519006552	putative homotetramer interface [polypeptide binding]; other site
656519006553	putative homodimer interface [polypeptide binding]; other site
656519006554	putative allosteric switch controlling residues; other site
656519006555	putative metal binding site [ion binding]; other site
656519006556	putative homodimer-homodimer interface [polypeptide binding]; other site
656519006557	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
656519006558	Phosphotransferase enzyme family; Region: APH; pfam01636
656519006559	active site
656519006560	substrate binding site [chemical binding]; other site
656519006561	ATP binding site [chemical binding]; other site
656519006562	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
656519006563	GT_2_like_a represents a glycosyltransferase family-2 subfamily with unknown function; Region: GT_2_like_a; cd02522
656519006564	Probable Catalytic site; other site
656519006565	The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709
656519006566	Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496
656519006567	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173
656519006568	N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911
656519006569	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
656519006570	dimer interface [polypeptide binding]; other site
656519006571	conserved gate region; other site
656519006572	putative PBP binding loops; other site
656519006573	ABC-ATPase subunit interface; other site
656519006574	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
656519006575	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
656519006576	dimer interface [polypeptide binding]; other site
656519006577	conserved gate region; other site
656519006578	putative PBP binding loops; other site
656519006579	ABC-ATPase subunit interface; other site
656519006580	nuc_hydro: Nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base. These enzymes vary in their substrate specificity.  This group contains eukaryotic, bacterial and archeal...; Region: nuc_hydro; cl00226
656519006581	active site
656519006582	Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897
656519006583	Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448
656519006584	active site residue [active]
656519006585	Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449
656519006586	active site residue [active]
656519006587	Zinc dependent phospholipase C; Region: Zn_dep_PLPC; cl03005
656519006588	Uncharacterized BCR, YaiI/YqxD family COG1671; Region: DUF188; cl00727
656519006589	Low specificity phosphatase (HAD superfamily) [General function prediction only]; Region: COG1778
656519006590	Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391
656519006591	NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822
656519006592	Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664
656519006593	trimerization site [polypeptide binding]; other site
656519006594	active site
656519006595	Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520
656519006596	Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453
656519006597	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
656519006598	catalytic residue [active]
656519006599	Uncharacterized protein family (UPF0051); Region: UPF0051; cl03223
656519006600	FeS assembly protein SufB; Region: sufB; TIGR01980
656519006601	Uncharacterized protein family (UPF0051); Region: UPF0051; cl03223
656519006602	FeS assembly ATPase SufC; Region: sufC; TIGR01978
656519006603	ABC-type transport system involved in Fe-S cluster assembly, ATPase component.  Biosynthesis of iron-sulfur clusters (Fe-S) depends on multiprotein systems.  The SUF system of E. coli and Erwinia chrysanthemi is important for Fe-S biogenesis under...; Region: ABC_FeS_Assembly; cd03217
656519006604	Walker A/P-loop; other site
656519006605	ATP binding site [chemical binding]; other site
656519006606	Q-loop/lid; other site
656519006607	ABC transporter signature motif; other site
656519006608	Walker B; other site
656519006609	D-loop; other site
656519006610	H-loop/switch region; other site
656519006611	pheromone autoinducer 2 transporter; Reviewed; Region: tqsA; cl00465
656519006612	Na+-transporting oxaloacetate decarboxylase beta subunit; Region: OAD_beta; cl00816
656519006613	pyruvate carboxylase subunit B; Validated; Region: PRK09282
656519006614	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
656519006615	carboxyltransferase (CT) interaction site; other site
656519006616	biotinylation site [posttranslational modification]; other site
656519006617	Oxaloacetate decarboxylase, gamma chain; Region: OAD_gamma; cl01458
656519006618	methylmalonyl-CoA decarboxylase alpha subunit; Region: mmdA; TIGR01117
656519006619	Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl15772
656519006620	Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl15772
656519006621	FdhD/NarQ family; Region: FdhD-NarQ; cl00659
656519006622	ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842
656519006623	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
656519006624	Walker A/P-loop; other site
656519006625	ATP binding site [chemical binding]; other site
656519006626	Q-loop/lid; other site
656519006627	ABC transporter signature motif; other site
656519006628	Walker B; other site
656519006629	D-loop; other site
656519006630	H-loop/switch region; other site
656519006631	TOBE domain; Region: TOBE_2; cl01440
656519006632	ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178
656519006633	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
656519006634	dimer interface [polypeptide binding]; other site
656519006635	conserved gate region; other site
656519006636	putative PBP binding loops; other site
656519006637	ABC-ATPase subunit interface; other site
656519006638	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
656519006639	dimer interface [polypeptide binding]; other site
656519006640	conserved gate region; other site
656519006641	putative PBP binding loops; other site
656519006642	ABC-ATPase subunit interface; other site
656519006643	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
656519006644	Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416
656519006645	Uncharacterized protein, DegV family COG1307; Region: DegV; cl00577
656519006646	F420-0:Gamma-glutamyl ligase; Region: F420_ligase; cl00644
656519006647	F420-0:Gamma-glutamyl ligase; Region: F420_ligase; cl00644
656519006648	Carbon dioxide concentrating mechanism K (CcmK)-like proteins, Bacterial Micro-Compartment (BMC) domain; Region: BMC_CcmK_like; cd07045
656519006649	Hexamer interface [polypeptide binding]; other site
656519006650	Hexagonal pore residue; other site
656519006651	ethanolamine utilization protein EutL; Provisional; Region: PRK15405
656519006652	ethanolamine utilization protein S (EutS), Bacterial Micro-Compartment (BMC) domain repeat 1; Region: BMC_EutL_repeat1; cd07049
656519006653	putative hexamer interface [polypeptide binding]; other site
656519006654	putative hexagonal pore; other site
656519006655	Bacterial Micro-Compartment (BMC) domain; Region: BMC; cl01982
656519006656	Hexamer interface [polypeptide binding]; other site
656519006657	Hexagonal pore residue; other site
656519006658	Ethanolamine ammonia-lyase light chain (EutC); Region: EutC; cl01762
656519006659	ethanolamine ammonia lyase large subunit; Provisional; Region: PRK15067
656519006660	Ethanolamine ammonia lyase large subunit (EutB); Region: EutB; pfam06751
656519006661	ethanolamine ammonia lyase large subunit; Provisional; Region: PRK15067
656519006662	Ethanolamine ammonia lyase large subunit (EutB); Region: EutB; pfam06751
656519006663	Ethanolamine utilisation protein EutA; Region: EutA; pfam06277
656519006664	ethanolamine utilization protein, PduT homolog; Region: eut_PduT; TIGR02526
656519006665	1,2-propanediol utilization protein T (PduT), Bacterial Micro-Compartment (BMC) domain repeat 1; Region: BMC_PduT_repeat1; cd07053
656519006666	putative hexamer interface [polypeptide binding]; other site
656519006667	putative hexagonal pore; other site
656519006668	1,2-propanediol utilization protein T (PduT), Bacterial Micro-Compartment (BMC) domain repeat 2; Region: BMC_PduT_repeat2; cd07054
656519006669	putative hexamer interface [polypeptide binding]; other site
656519006670	putative hexagonal pore; other site
656519006671	Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637
656519006672	Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391
656519006673	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
656519006674	motif II; other site
656519006675	Na+/H+ antiporter [Energy production and conversion]; Region: NhaC; COG1757
656519006676	C4-dicarboxylate anaerobic carrier; Region: DcuC; cl15356
656519006677	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
656519006678	sugar efflux transporter; Region: 2A0120; TIGR00899
656519006679	glycerate dehydrogenase; Provisional; Region: PRK06487
656519006680	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
656519006681	lipoyl synthase; Provisional; Region: PRK05481
656519006682	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
656519006683	FeS/SAM binding site; other site
656519006684	Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057
656519006685	Nitroreductase-like family 4.  A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_4; cd02140
656519006686	dimer interface [polypeptide binding]; other site
656519006687	FMN binding site [chemical binding]; other site
656519006688	Uncharacterized conserved protein [Function unknown]; Region: COG2006
656519006689	Domain of unknown function (DUF362); Region: DUF362; pfam04015
656519006690	transaminase; Validated; Region: PRK07324
656519006691	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
656519006692	pyridoxal 5'-phosphate binding site [chemical binding]; other site
656519006693	homodimer interface [polypeptide binding]; other site
656519006694	catalytic residue [active]
656519006695	S-adenosyl-L-homocysteine hydrolase; Provisional; Region: PRK05476
656519006696	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
656519006697	oligomerization interface [polypeptide binding]; other site
656519006698	active site
656519006699	NAD+ binding site [chemical binding]; other site
656519006700	TlpA-like family; composed of  TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966
656519006701	catalytic residues [active]
656519006702	Xanthine/uracil/vitamin C permease [Nucleotide transport and    metabolism]; Region: COG2252
656519006703	Adenine deaminase [Nucleotide transport and metabolism]; Region: AdeC; COG1001
656519006704	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
656519006705	Adenine deaminase (AdeC) directly deaminates adenine to form hypoxanthine. This reaction is part of one of the adenine salvage pathways, as well as the degradation pathway. It is important for adenine utilization as a purine, as well as a nitrogen source...; Region: AdeC; cd01295
656519006706	active site
656519006707	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
656519006708	dihydroorotate dehydrogenase (subfamily 1) family protein; Region: pyrD_sub1_fam; TIGR01037
656519006709	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl09108
656519006710	phosphate binding site [ion binding]; other site
656519006711	RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409
656519006712	4Fe-4S dicluster domain; Region: Fer4_7; pfam12838
656519006713	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
656519006714	Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738
656519006715	Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; cl03161
656519006716	Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738
656519006717	Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080
656519006718	[2Fe-2S] binding domain; Region: Fer2_2; pfam01799
656519006719	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319
656519006720	CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; cl08390
656519006721	putative chlorohydrolase/aminohydrolase; Validated; Region: PRK07203
656519006722	TRZ/ATZ family contains enzymes from the atrazine degradation pathway and related hydrolases. Atrazine, a chlorinated herbizide, can be catabolized by a variety of different bacteria. The first three steps of the atrazine dehalogenation pathway are...; Region: ATZ_TRZ_like; cd01298
656519006723	active site
656519006724	putative substrate binding pocket [chemical binding]; other site
656519006725	hydroxydechloroatrazine ethylaminohydrolase; Reviewed; Region: PRK08203
656519006726	TRZ/ATZ family contains enzymes from the atrazine degradation pathway and related hydrolases. Atrazine, a chlorinated herbizide, can be catabolized by a variety of different bacteria. The first three steps of the atrazine dehalogenation pathway are...; Region: ATZ_TRZ_like; cd01298
656519006727	active site
656519006728	putative substrate binding pocket [chemical binding]; other site
656519006729	Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080
656519006730	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cl00159
656519006731	[2Fe-2S] binding domain; Region: Fer2_2; pfam01799
656519006732	xanthine dehydrogenase subunit XdhB; Provisional; Region: PRK09971
656519006733	CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; cl08390
656519006734	Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529
656519006735	Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; cl03161
656519006736	Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738
656519006737	probable carbamoyltransferase YgeW; Region: ygeW; TIGR03316
656519006738	Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729
656519006739	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
656519006740	peptidase; Reviewed; Region: PRK13004
656519006741	M20 Peptidases with similarity to acetylornithine deacetylases and succinyl-diaminopimelate desuccinylases; Region: M20_ArgE_DapE_like4; cd05649
656519006742	putative metal binding site [ion binding]; other site
656519006743	putative dimer interface [polypeptide binding]; other site
656519006744	DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943
656519006745	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
656519006746	non-specific DNA binding site [nucleotide binding]; other site
656519006747	salt bridge; other site
656519006748	sequence-specific DNA binding site [nucleotide binding]; other site
656519006749	Cupin domain; Region: Cupin_2; cl09118
656519006750	threonine synthase; Validated; Region: PRK06260
656519006751	Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of  threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants; Region: Thr-synth_1; cd01563
656519006752	homodimer interface [polypeptide binding]; other site
656519006753	pyridoxal 5'-phosphate binding site [chemical binding]; other site
656519006754	catalytic residue [active]
656519006755	Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342
656519006756	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
656519006757	OsmC-like protein; Region: OsmC; cl00767
656519006758	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761
656519006759	CoA-disulfide reductase; Region: CoA_CoA_reduc; TIGR03385
656519006760	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
656519006761	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
656519006762	L-cysteine desulfidase [Amino acid transport and metabolism]; Region: COG3681
656519006763	Serine dehydratase alpha chain; Region: SDH_alpha; cl12120
656519006764	Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cl00214
656519006765	intersubunit interface [polypeptide binding]; other site
656519006766	active site
656519006767	Zn2+ binding site [ion binding]; other site
656519006768	Acetamidase/Formamidase family; Region: FmdA_AmdA; cl01023
656519006769	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
656519006770	Major Facilitator Superfamily; Region: MFS_1; pfam07690
656519006771	putative substrate translocation pore; other site
656519006772	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: APH_ChoK_like; cd05120
656519006773	active site
656519006774	ATP binding site [chemical binding]; other site
656519006775	Kae1-associated kinase Bud32; Region: arch_bud32; TIGR03724
656519006776	O-Antigen ligase; Region: Wzy_C; cl04850
656519006777	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
656519006778	This family is most closely related to the GT1 family of glycosyltransferases. WabH in Klebsiella pneumoniae has been shown to transfer a GlcNAc residue from UDP-GlcNAc onto the acceptor GalUA residue in the cellular outer core; Region: GT1_WabH_like; cd03811
656519006779	putative ADP-binding pocket [chemical binding]; other site
656519006780	UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511
656519006781	putative metal binding site; other site
656519006782	ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859
656519006783	Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789
656519006784	Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789
656519006785	putative active site [active]
656519006786	ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859
656519006787	Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789
656519006788	Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789
656519006789	putative active site [active]
656519006790	3-deoxy-D-manno-octulosonic-acid transferase; Reviewed; Region: PRK05749
656519006791	3-Deoxy-D-manno-octulosonic-acid transferase (kdotransferase); Region: Glycos_transf_N; pfam04413
656519006792	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
656519006793	Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279
656519006794	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984
656519006795	putative acyl-acceptor binding pocket; other site
656519006796	D-arabinose 5-phosphate isomerase; Provisional; Region: PRK10892
656519006797	KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014
656519006798	putative active site [active]
656519006799	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with KpsF/GutQ domains in the API [A5P (D-arabinose 5-phosphate) isomerase] protein.  These APIs catalyze the conversion of the pentose pathway...; Region: CBS_pair_KpsF_GutQ_assoc; cd04604
656519006800	DAHP synthetase I family; Region: DAHP_synth_1; pfam00793
656519006801	NeuB family; Region: NeuB; cl00496
656519006802	CMP-KDO synthetase catalyzes the activation of KDO which is an essential component of the lipopolysaccharide; Region: CMP-KDO-Synthetase; cd02517
656519006803	Ligand binding site; other site
656519006804	oligomer interface; other site
656519006805	Tetraacyldisaccharide-1-P 4'-kinase [Cell envelope biogenesis, outer membrane]; Region: LpxK; COG1663
656519006806	Tetraacyldisaccharide-1-P 4'-kinase; Region: LpxK; cl03652
656519006807	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: DUF374; Region: LPLAT_DUF374-like; cd07983
656519006808	putative acyl-acceptor binding pocket; other site
656519006809	lipid A export permease/ATP-binding protein MsbA; Region: MsbA_lipidA; TIGR02203
656519006810	ABC transporter transmembrane region; Region: ABC_membrane; cl00549
656519006811	MsbA is an essential ABC transporter, closely related to eukaryotic MDR proteins.  ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars, ions, peptides, and more complex organic...; Region: ABCC_MsbA; cd03251
656519006812	Walker A/P-loop; other site
656519006813	ATP binding site [chemical binding]; other site
656519006814	Q-loop/lid; other site
656519006815	ABC transporter signature motif; other site
656519006816	Walker B; other site
656519006817	D-loop; other site
656519006818	H-loop/switch region; other site
656519006819	HutP; Region: HutP; cl07944
656519006820	ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614
656519006821	Cobalamin binding protein BtuF.  These proteins have been shown to function as initial receptors in ABC transport of vitamin B12 (cobalamin) in eubacterial and some archaeal species.  They belong to the TroA superfamily of helical backbone metal receptor...; Region: BtuF; cd01144
656519006822	cobalamin binding residues [chemical binding]; other site
656519006823	putative BtuC binding residues; other site
656519006824	dimer interface [polypeptide binding]; other site
656519006825	NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553
656519006826	homodimer interface [polypeptide binding]; other site
656519006827	NAD synthase; Region: NAD_synthase; pfam02540
656519006828	NAD binding pocket [chemical binding]; other site
656519006829	ATP binding pocket [chemical binding]; other site
656519006830	Mg binding site [ion binding]; other site
656519006831	active-site loop [active]
656519006832	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
656519006833	substrate binding site [chemical binding]; other site
656519006834	activation loop (A-loop); other site
656519006835	glucose-6-phosphate isomerase; Provisional; Region: PRK00973
656519006836	Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015
656519006837	active site
656519006838	dimer interface [polypeptide binding]; other site
656519006839	Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016
656519006840	dimer interface [polypeptide binding]; other site
656519006841	active site
656519006842	Predicted permease; Region: DUF318; pfam03773
656519006843	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
656519006844	The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709
656519006845	nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790
656519006846	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
656519006847	dimer interface [polypeptide binding]; other site
656519006848	conserved gate region; other site
656519006849	putative PBP binding loops; other site
656519006850	ABC-ATPase subunit interface; other site
656519006851	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
656519006852	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
656519006853	dimer interface [polypeptide binding]; other site
656519006854	conserved gate region; other site
656519006855	putative PBP binding loops; other site
656519006856	ABC-ATPase subunit interface; other site
656519006857	Superoxide reductase-like (SORL) domain, class II; SORL-domains are present in a family of mononuclear non-heme iron proteins that includes superoxide reductase and desulfoferrodoxin.  Superoxide reductase-like proteins scavenge superoxide anion radicals...; Region: SORL_classII; cd03172
656519006858	non-heme iron binding site [ion binding]; other site
656519006859	tetramer interface [polypeptide binding]; other site
656519006860	Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891
656519006861	GTP-binding protein TypA/BipA; Region: TypA_BipA; TIGR01394
656519006862	G1 box; other site
656519006863	putative GEF interaction site [polypeptide binding]; other site
656519006864	GTP/Mg2+ binding site [chemical binding]; other site
656519006865	Switch I region; other site
656519006866	G2 box; other site
656519006867	G3 box; other site
656519006868	Switch II region; other site
656519006869	G4 box; other site
656519006870	G5 box; other site
656519006871	BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu.  BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691
656519006872	BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants.  BipA is a highly...; Region: BipA_TypA_C; cd03710
656519006873	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box protein; Region: CSP_CDS; cd04458
656519006874	DNA-binding site [nucleotide binding]; DNA binding site
656519006875	RNA-binding motif; other site
656519006876	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box protein; Region: CSP_CDS; cd04458
656519006877	DNA-binding site [nucleotide binding]; DNA binding site
656519006878	RNA-binding motif; other site
656519006879	tryptophan synthase subunit alpha; Provisional; Region: trpA; PRK13111
656519006880	Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724
656519006881	substrate binding site [chemical binding]; other site
656519006882	active site
656519006883	catalytic residues [active]
656519006884	heterodimer interface [polypeptide binding]; other site
656519006885	Tryptophan synthase-beta:  Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446
656519006886	Pyridoxal-phosphate dependent enzyme; Region: PALP; pfam00291
656519006887	pyridoxal 5'-phosphate binding site [chemical binding]; other site
656519006888	catalytic residue [active]
656519006889	Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are monomeric; Region: PRAI; cd00405
656519006890	active site
656519006891	Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331
656519006892	active site
656519006893	ribulose/triose binding site [chemical binding]; other site
656519006894	phosphate binding site [ion binding]; other site
656519006895	substrate (anthranilate) binding pocket [chemical binding]; other site
656519006896	product (indole) binding pocket [chemical binding]; other site
656519006897	anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188
656519006898	Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885
656519006899	Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591
656519006900	para-aminobenzoate synthase component II; Provisional; Region: PRK08857
656519006901	Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743
656519006902	glutamine binding [chemical binding]; other site
656519006903	catalytic triad [active]
656519006904	anthranilate synthase component I, non-proteobacterial lineages; Region: trpE_most; TIGR00564
656519006905	Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715
656519006906	chorismate binding enzyme; Region: Chorismate_bind; cl10555
656519006907	Predicted divalent heavy-metal cations transporter [Inorganic ion transport and metabolism]; Region: COG0428; cl00437
656519006908	Predicted divalent heavy-metal cations transporter [Inorganic ion transport and metabolism]; Region: COG0428; cl00437
656519006909	Glycerol dehydrogenase and related enzymes [Energy production and conversion]; Region: GldA; COG0371
656519006910	Glycerol dehydrogenases (GlyDH) catalyzes oxidation of glycerol to dihydroxyacetone in glycerol dissmilation; Region: GlyDH; cd08170
656519006911	dimer interface [polypeptide binding]; other site
656519006912	active site
656519006913	metal binding site [ion binding]; metal-binding site
656519006914	maltose phosphorylase; Provisional; Region: PRK13807
656519006915	Glycosyl hydrolase family 65, N-terminal domain; Region: Glyco_hydro_65N; pfam03636
656519006916	Glycosyl hydrolase family 65 central catalytic domain; Region: Glyco_hydro_65m; pfam03632
656519006917	Glycosyl hydrolase family 65, C-terminal domain; Region: Glyco_hydro_65C; pfam03633
656519006918	Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419
656519006919	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
656519006920	motif II; other site
656519006921	GAF domain; Region: GAF; cl15785
656519006922	Membrane protein of unknown function (DUF340); Region: DUF340; cl01028
656519006923	Predicted amino acid racemase [Amino acid transport and metabolism]; Region: COG3457
656519006924	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261
656519006925	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
656519006926	catalytic residue [active]
656519006927	Group of bacterial proteins containing an alpha crystallin domain (ACD) similar to Lactobacillus plantarum (Lp) small heat shock proteins (sHsp) HSP 18.5, HSP 18.55 and HSP 19.3. sHsps are molecular chaperones that suppress protein aggregation and...; Region: ACD_LpsHSP_like; cd06471
656519006928	putative dimer interface [polypeptide binding]; other site
656519006929	AAA domain; Region: AAA_32; pfam13654
656519006930	lon-related putative ATP-dependent protease; Region: lon_rel; TIGR00764
656519006931	Subunit ChlI of Mg-chelatase; Region: ChlI; cl12214
656519006932	redox-sensing transcriptional repressor Rex; Provisional; Region: PRK05472
656519006933	Putative DNA-binding protein N-terminus; Region: Put_DNA-bind_N; pfam06971
656519006934	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
656519006935	phenylhydantoinase; Validated; Region: PRK08323
656519006936	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
656519006937	active site
656519006938	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410
656519006939	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
656519006940	Walker A/P-loop; other site
656519006941	ATP binding site [chemical binding]; other site
656519006942	Q-loop/lid; other site
656519006943	ABC transporter signature motif; other site
656519006944	Walker B; other site
656519006945	D-loop; other site
656519006946	H-loop/switch region; other site
656519006947	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
656519006948	dimer interface [polypeptide binding]; other site
656519006949	conserved gate region; other site
656519006950	putative PBP binding loops; other site
656519006951	ABC-ATPase subunit interface; other site
656519006952	ABC-type tungstate transport system, permease component [Coenzyme metabolism]; Region: TupB; COG2998
656519006953	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
656519006954	alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403
656519006955	Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333
656519006956	Ca binding site [ion binding]; other site
656519006957	active site
656519006958	catalytic site [active]
656519006959	Transcriptional regulators [Transcription]; Region: PurR; COG1609
656519006960	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
656519006961	DNA binding site [nucleotide binding]
656519006962	domain linker motif; other site
656519006963	Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267
656519006964	ligand binding site [chemical binding]; other site
656519006965	dimerization interface [polypeptide binding]; other site
656519006966	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
656519006967	Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416
656519006968	Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826
656519006969	Helix-turn-helix domains; Region: HTH; cl00088
656519006970	Integrase core domain; Region: rve; cl01316
656519006971	Predicted amidohydrolase [General function prediction only]; Region: COG0388
656519006972	Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cl11424
656519006973	active site
656519006974	catalytic triad [active]
656519006975	dimer interface [polypeptide binding]; other site
656519006976	Outer membrane cobalamin receptor protein [Coenzyme metabolism]; Region: BtuB; COG4206
656519006977	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
656519006978	N-terminal plug; other site
656519006979	ligand-binding site [chemical binding]; other site
656519006980	ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120
656519006981	ABC transporters, involved in the uptake of siderophores, heme, and vitamin B12, are widely conserved in bacteria and archaea.  Only very few species lack representatives of the siderophore family transporters. The E. coli BtuCD protein is an ABC...; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214
656519006982	Walker A/P-loop; other site
656519006983	ATP binding site [chemical binding]; other site
656519006984	Q-loop/lid; other site
656519006985	ABC transporter signature motif; other site
656519006986	Walker B; other site
656519006987	D-loop; other site
656519006988	H-loop/switch region; other site
656519006989	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
656519006990	ABC-ATPase subunit  interface; other site
656519006991	dimer interface [polypeptide binding]; other site
656519006992	putative PBP binding regions; other site
656519006993	Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+.  Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262
656519006994	intersubunit interface [polypeptide binding]; other site
656519006995	Cobalamin-5-phosphate synthase; Region: CobS; cl00415
656519006996	Adenosylcobinamide kinase / adenosylcobinamide phosphate guanyltransferase (CobU). CobU is bifunctional cobalbumin biosynthesis enzymes which display adenosylcobinamide kinase and adenosylcobinamide phosphate guanyltransferase activity. This enzyme is a...; Region: CobU; cd00544
656519006997	homotrimer interface [polypeptide binding]; other site
656519006998	Walker A motif; other site
656519006999	GTP binding site [chemical binding]; other site
656519007000	Walker B motif; other site
656519007001	Phosphoribosyltransferase; Region: DBI_PRT; pfam02277
656519007002	Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (DMB-PRT), also called CobT; Region: DMB-PRT_CobT; cd02439
656519007003	putative dimer interface [polypeptide binding]; other site
656519007004	active site pocket [active]
656519007005	putative cataytic base [active]
656519007006	threonine-phosphate decarboxylase; Provisional; Region: PRK06358
656519007007	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
656519007008	pyridoxal 5'-phosphate binding site [chemical binding]; other site
656519007009	homodimer interface [polypeptide binding]; other site
656519007010	catalytic residue [active]
656519007011	Protein involved in propanediol utilization, and related proteins (includes coumermycin biosynthetic protein), possible kinase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: PduX; COG4542
656519007012	GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288
656519007013	CobD/Cbib protein; Region: CobD_Cbib; cl00561
656519007014	cobyrinic acid a,c-diamide synthase; Validated; Region: PRK01077
656519007015	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
656519007016	Type 1 glutamine amidotransferase (GATase1) domain found in Cobyrinic Acid a,c-Diamide Synthase; Region: GATase1_CobB; cd03130
656519007017	catalytic triad [active]
656519007018	cobalamin biosynthesis protein CbiG; Validated; Region: PRK05788
656519007019	Cobalamin synthesis G N-terminal; Region: CbiG_N; pfam11760
656519007020	Cobalamin biosynthesis central region; Region: CbiG_mid; pfam11761
656519007021	Cobalamin synthesis G C-terminus; Region: CbiG_C; cl12133
656519007022	Precorrin-6x reductase [Coenzyme metabolism]; Region: CobK; COG2099
656519007023	Precorrin-6x reductase CbiJ/CobK; Region: CbiJ; cl00922
656519007024	Precorrin-3B methylase [Coenzyme metabolism]; Region: CobJ; cl00304
656519007025	Tetrapyrrole (Corrin/Porphyrin) Methylases; Region: TP_methylase; pfam00590
656519007026	Precorrin-3B methylase [Coenzyme metabolism]; Region: CobJ; cl00304
656519007027	Tetrapyrrole (Corrin/Porphyrin) Methylases; Region: TP_methylase; pfam00590
656519007028	Cobalt chelatase (CbiK); Region: CbiK; pfam06180
656519007029	Anaerobic cobalamin biosynthetic cobalt chelatase (CbiK), N-terminal domain. CbiK is part of the cobalt-early path for cobalamin biosynthesis. It catalyzes the insertion of cobalt into the oxidized form of precorrin-2, factor II (sirohydrochlorin), the...; Region: CbiK_N; cd03412
656519007030	active site
656519007031	C-terminal domain interface [polypeptide binding]; other site
656519007032	Anaerobic cobalamin biosynthetic cobalt chelatase (CbiK), C-terminal domain. CbiK is part of the cobalt-early path for cobalamin biosynthesis. It catalyzes the insertion of cobalt into the oxidized form of precorrin-2, factor II (sirohydrochlorin), the...; Region: CbiK_C; cd03413
656519007033	active site
656519007034	N-terminal domain interface [polypeptide binding]; other site
656519007035	Precorrin-3B methylase [Coenzyme metabolism]; Region: CobJ; cl00304
656519007036	Tetrapyrrole (Corrin/Porphyrin) Methylases; Region: TP_methylase; pfam00590
656519007037	cobalt-precorrin-6Y C(15)-methyltransferase; Validated; Region: PRK08287
656519007038	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
656519007039	S-adenosylmethionine binding site [chemical binding]; other site
656519007040	Precorrin-3B methylase [Coenzyme metabolism]; Region: CobJ; cl00304
656519007041	Tetrapyrrole (Corrin/Porphyrin) Methylases; Region: TP_methylase; pfam00590
656519007042	CbiD; Region: CbiD; cl00828
656519007043	Precorrin isomerase [Coenzyme metabolism]; Region: CobH; cl00913
656519007044	Precorrin-8X methylmutase; Region: CbiC; pfam02570
656519007045	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
656519007046	Walker A motif; other site
656519007047	ATP binding site [chemical binding]; other site
656519007048	Walker B motif; other site
656519007049	cobyric acid synthase; Provisional; Region: PRK00784
656519007050	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
656519007051	Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750
656519007052	catalytic triad [active]
656519007053	cobyric acid synthase; Provisional; Region: PRK00784
656519007054	Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750
656519007055	catalytic triad [active]
656519007056	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
656519007057	catalytic core [active]
656519007058	Escherichia coli YaeB and related proteins; Region: UPF0066; cd09281
656519007059	homodimer interaction site [polypeptide binding]; other site
656519007060	cofactor binding site; other site
656519007061	Formylmethanofuran dehydrogenase subunit E [Energy production and conversion]; Region: COG2191
656519007062	FmdE, Molybdenum formylmethanofuran dehydrogenase operon; Region: FmdE; pfam02663
656519007063	ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120
656519007064	ABC component of the metal-type transporters.  This family includes transporters involved in the uptake of various metallic cations such as iron, manganese, and zinc.  The ATPases of this group of transporters are very similar to members of...; Region: ABC_Metallic_Cations; cd03235
656519007065	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
656519007066	ABC-ATPase subunit  interface; other site
656519007067	dimer interface [polypeptide binding]; other site
656519007068	putative PBP binding regions; other site
656519007069	Metal binding protein HemV-2.  These proteins are predicted to function as initial receptors in ABC transport of metal ions.  They belong to the TroA superfamily of helical backbone metal receptor proteins that share a distinct fold and ligand binding...; Region: HemV-2; cd01147
656519007070	Periplasmic binding protein; Region: Peripla_BP_2; pfam01497
656519007071	putative metal binding site [ion binding]; other site
656519007072	nickel responsive regulator; Provisional; Region: PRK04460
656519007073	NikR C terminal nickel binding domain; Region: NikR_C; pfam08753
656519007074	NCAIR mutase (PurE)-related proteins [General function prediction only]; Region: COG1691
656519007075	AIR carboxylase; Region: AIRC; cl00310
656519007076	ATP-utilizing enzymes of the PP-loop superfamily [General function prediction only]; Region: COG1606
656519007077	This is a subfamily of Adenine nucleotide alpha hydrolases superfamily. Adenine nucleotide alpha hydrolases superfamily  includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which  binds to Adenosine group.  This subfamily; Region: Alpha_ANH_like_I; cd01990
656519007078	Ligand Binding Site [chemical binding]; other site
656519007079	B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293
656519007080	hypothetical protein; Provisional; Region: PRK00955
656519007081	Domain of unknown function (DUF3362); Region: DUF3362; pfam11842
656519007082	nylC-like family; composed of proteins with similarity to Flavobacterium endo-type 6-aminohexanoate-oligomer hydrolase (EIII), the product of the nylon oligomer degradation gene, nylC. EIII is an amide hydrolase that catalyzes the degradation of...; Region: nylC_like; cd02252
656519007083	putative active site pocket [active]
656519007084	cleavage site
656519007085	phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135
656519007086	PhoU domain; Region: PhoU; pfam01895
656519007087	PhoU domain; Region: PhoU; pfam01895
656519007088	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
656519007089	Beta-eliminating lyase; Region: Beta_elim_lyase; pfam01212
656519007090	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
656519007091	catalytic residue [active]
656519007092	Branched-chain amino acid transport protein (AzlD); Region: AzlD; cl00735
656519007093	AzlC protein; Region: AzlC; cl00570
656519007094	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173
656519007095	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
656519007096	dimer interface [polypeptide binding]; other site
656519007097	conserved gate region; other site
656519007098	putative PBP binding loops; other site
656519007099	ABC-ATPase subunit interface; other site
656519007100	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
656519007101	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
656519007102	dimer interface [polypeptide binding]; other site
656519007103	conserved gate region; other site
656519007104	putative PBP binding loops; other site
656519007105	ABC-ATPase subunit interface; other site
656519007106	The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995
656519007107	Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496
656519007108	Predicted glutamine amidotransferases [General function prediction only]; Region: COG2071
656519007109	Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745
656519007110	catalytic triad [active]
656519007111	XdhC and CoxI family; Region: XdhC_CoxI; pfam02625
656519007112	XdhC Rossmann domain; Region: XdhC_C; pfam13478
656519007113	ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120
656519007114	ABC transporters, involved in the uptake of siderophores, heme, and vitamin B12, are widely conserved in bacteria and archaea.  Only very few species lack representatives of the siderophore family transporters. The E. coli BtuCD protein is an ABC...; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214
656519007115	Walker A/P-loop; other site
656519007116	ATP binding site [chemical binding]; other site
656519007117	Q-loop/lid; other site
656519007118	ABC transporter signature motif; other site
656519007119	Walker B; other site
656519007120	D-loop; other site
656519007121	H-loop/switch region; other site
656519007122	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
656519007123	ABC-ATPase subunit  interface; other site
656519007124	dimer interface [polypeptide binding]; other site
656519007125	putative PBP binding regions; other site
656519007126	Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+.  Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262
656519007127	ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614
656519007128	intersubunit interface [polypeptide binding]; other site
656519007129	Helix-turn-helix domains; Region: HTH; cl00088
656519007130	GT_2_like_f is a subfamily of the glycosyltransferase family 2 (GT-2) with unknown function; Region: GT_2_like_f; cd04182
656519007131	Ligand binding site; other site
656519007132	metal-binding site
656519007133	cytoplasmic alpha-amylase; Reviewed; Region: PRK09441
656519007134	Alpha amylase catalytic domain found in bacterial and fungal Alpha amylases (also called 1,4-alpha-D-glucan-4-glucanohydrolase); Region: AmyAc_bac_fung_AmyA; cd11318
656519007135	active site
656519007136	Na/Ca binding site [ion binding]; other site
656519007137	catalytic site [active]
656519007138	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box protein; Region: CSP_CDS; cd04458
656519007139	DNA-binding site [nucleotide binding]; DNA binding site
656519007140	RNA-binding motif; other site
656519007141	Anaerobic ribonucleoside-triphosphate reductase; Region: NRDD; pfam13597
656519007142	anaerobic ribonucleoside-triphosphate reductase activating protein; Region: NrdG2; TIGR02495
656519007143	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
656519007144	FeS/SAM binding site; other site
656519007145	ATP cone domain; Region: ATP-cone; pfam03477
656519007146	Class III ribonucleotide reductase; Region: RNR_III; cd01675
656519007147	effector binding site; other site
656519007148	active site
656519007149	ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK08332
656519007150	Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein; Region: Hint; cl15780
656519007151	Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939
656519007152	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4399
656519007153	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4399
656519007154	Protein of unknown function (DUF541); Region: SIMPL; cl01077
656519007155	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459
656519007156	PAS domain S-box; Region: sensory_box; TIGR00229
656519007157	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
656519007158	metal binding site [ion binding]; metal-binding site
656519007159	I-site; other site
656519007160	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
656519007161	Zn2+ binding site [ion binding]; other site
656519007162	Mg2+ binding site [ion binding]; other site
656519007163	Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053
656519007164	Cation efflux family; Region: Cation_efflux; cl00316
656519007165	Transposase, Mutator family; Region: Transposase_mut; pfam00872
656519007166	MULE transposase domain; Region: MULE; pfam10551
656519007167	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
656519007168	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
656519007169	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
656519007170	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
656519007171	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
656519007172	bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881
656519007173	Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal  ATIC formylase domain that formylates...; Region: IMPCH; cd01421
656519007174	purine monophosphate binding site [chemical binding]; other site
656519007175	dimer interface [polypeptide binding]; other site
656519007176	putative catalytic residues [active]
656519007177	AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362
656519007178	AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362
656519007179	phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647
656519007180	Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645
656519007181	active site
656519007182	substrate binding site [chemical binding]; other site
656519007183	cosubstrate binding site; other site
656519007184	catalytic site [active]
656519007185	phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385
656519007186	PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196
656519007187	dimerization interface [polypeptide binding]; other site
656519007188	putative ATP binding site [chemical binding]; other site
656519007189	amidophosphoribosyltransferase; Provisional; Region: PRK05793
656519007190	Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of  glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715
656519007191	active site
656519007192	tetramer interface [polypeptide binding]; other site
656519007193	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
656519007194	active site
656519007195	phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362
656519007196	bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415
656519007197	ATP binding site [chemical binding]; other site
656519007198	active site
656519007199	substrate binding site [chemical binding]; other site
656519007200	Adenylosuccinate lyase [Nucleotide transport and metabolism]; Region: PurB; COG0015
656519007201	Adenylsuccinate lyase (ASL)_like; Region: Adenylsuccinate_lyase_like; cd01595
656519007202	active site
656519007203	tetramer interface [polypeptide binding]; other site
656519007204	Lyase class I_like superfamily: contains the lyase class I family, histidine ammonia-lyase and phenylalanine ammonia-lyase, which catalyze similar beta-elimination reactions; Region: Lyase_I_like; cl00013
656519007205	AIR carboxylase; Region: AIRC; cl00310
656519007206	phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019
656519007207	ATP-grasp domain; Region: ATP-grasp_4; cl03087
656519007208	phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885
656519007209	Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844
656519007210	ATP-grasp domain; Region: ATP-grasp_4; cl03087
656519007211	Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843
656519007212	dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606
656519007213	Glucose / Sorbosone dehydrogenase; Region: GSDH; pfam07995
656519007214	YibE/F-like protein; Region: YibE_F; cl02259
656519007215	Alkaline phosphatase [Inorganic ion transport and metabolism]; Region: PhoA; COG1785
656519007216	Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cd00016
656519007217	dimer interface [polypeptide binding]; other site
656519007218	active site
656519007219	Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cl15837
656519007220	dimer interface [polypeptide binding]; other site
656519007221	RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651
656519007222	Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078
656519007223	putative active site [active]
656519007224	putative NTP binding site [chemical binding]; other site
656519007225	putative nucleic acid binding site [nucleotide binding]; other site
656519007226	Group II intron, maturase-specific domain; Region: GIIM; pfam08388
656519007227	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
656519007228	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
656519007229	active site
656519007230	phosphorylation site [posttranslational modification]
656519007231	intermolecular recognition site; other site
656519007232	dimerization interface [polypeptide binding]; other site
656519007233	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
656519007234	Walker A motif; other site
656519007235	ATP binding site [chemical binding]; other site
656519007236	Walker B motif; other site
656519007237	arginine finger; other site
656519007238	Helix-turn-helix domains; Region: HTH; cl00088
656519007239	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
656519007240	dimer interface [polypeptide binding]; other site
656519007241	phosphorylation site [posttranslational modification]
656519007242	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
656519007243	ATP binding site [chemical binding]; other site
656519007244	Mg2+ binding site [ion binding]; other site
656519007245	G-X-G motif; other site
656519007246	NMT1-like family; Region: NMT1_2; cl15260
656519007247	ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; pfam12974
656519007248	bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase protein; Reviewed; Region: PRK02759
656519007249	Phosphoribosyl-AMP cyclohydrolase; Region: PRA-CH; cl00344
656519007250	MazG nucleotide pyrophosphohydrolase domain; Region: MazG; cl00345
656519007251	The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731
656519007252	Histidine biosynthesis protein; Region: His_biosynth; pfam00977
656519007253	substrate binding site [chemical binding]; other site
656519007254	glutamase interaction surface [polypeptide binding]; other site
656519007255	HisA.  Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732
656519007256	phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Region: TIGR00007
656519007257	catalytic residues [active]
656519007258	imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13141
656519007259	Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748
656519007260	putative active site [active]
656519007261	oxyanion strand; other site
656519007262	catalytic triad [active]
656519007263	imidazoleglycerol-phosphate dehydratase; Validated; Region: hisB; PRK00951
656519007264	Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914
656519007265	putative active site pocket [active]
656519007266	4-fold oligomerization interface [polypeptide binding]; other site
656519007267	metal binding residues [ion binding]; metal-binding site
656519007268	3-fold/trimer interface [polypeptide binding]; other site
656519007269	histidinol-phosphate aminotransferase; Region: hisC; TIGR01141
656519007270	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
656519007271	pyridoxal 5'-phosphate binding site [chemical binding]; other site
656519007272	homodimer interface [polypeptide binding]; other site
656519007273	catalytic residue [active]
656519007274	Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572
656519007275	histidinol dehydrogenase; Region: hisD; TIGR00069
656519007276	NAD binding site [chemical binding]; other site
656519007277	dimerization interface [polypeptide binding]; other site
656519007278	product binding site; other site
656519007279	substrate binding site [chemical binding]; other site
656519007280	zinc binding site [ion binding]; other site
656519007281	catalytic residues [active]
656519007282	ATP phosphoribosyltransferase; Region: HisG; cl15266
656519007283	ATP phosphoribosyltransferase regulatory subunit; Provisional; Region: hisZ; PRK12292
656519007284	Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: HisRS-like_core; cd00773
656519007285	dimer interface [polypeptide binding]; other site
656519007286	motif 1; other site
656519007287	active site
656519007288	motif 2; other site
656519007289	motif 3; other site
656519007290	histidinol phosphate phosphatase, HisJ family; Region: hisJ_fam; TIGR01856
656519007291	Trehalose-6-phosphatase [Carbohydrate transport and metabolism]; Region: OtsB; COG1877
656519007292	Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391
656519007293	Trehalose-6-Phosphate Synthase (TPS) is a glycosyltransferase that catalyses the synthesis of alpha,alpha-1,1-trehalose-6-phosphate from glucose-6-phosphate using a UDP-glucose donor. It is a key enzyme in the trehalose synthesis pathway. Trehalose is a...; Region: GT1_TPS; cd03788
656519007294	alpha,alpha-trehalose-phosphate synthase [UDP-forming]; Region: trehalose_OtsA; TIGR02400
656519007295	active site
656519007296	homotetramer interface [polypeptide binding]; other site
656519007297	Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446
656519007298	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
656519007299	dimer interface [polypeptide binding]; other site
656519007300	conserved gate region; other site
656519007301	putative PBP binding loops; other site
656519007302	ABC-ATPase subunit interface; other site
656519007303	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
656519007304	dimer interface [polypeptide binding]; other site
656519007305	conserved gate region; other site
656519007306	putative PBP binding loops; other site
656519007307	ABC-ATPase subunit interface; other site
656519007308	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
656519007309	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
656519007310	glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK05293
656519007311	ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508
656519007312	ligand binding site; other site
656519007313	oligomer interface; other site
656519007314	Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651
656519007315	dimer interface [polypeptide binding]; other site
656519007316	N-terminal domain interface [polypeptide binding]; other site
656519007317	sulfate 1 binding site; other site
656519007318	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
656519007319	phosphoglycerate transporter family protein; Region: 2A0104; TIGR00881
656519007320	putative substrate translocation pore; other site
656519007321	Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752
656519007322	Patatin-like phospholipase domain containing protein 6, protein 7, and fungal NTE1; Region: Pat_PNPLA6_PNPLA7_NTE1_like; cd07205
656519007323	active site
656519007324	nucleophile elbow; other site
656519007325	NAD-dependent deacetylase; Provisional; Region: PRK00481
656519007326	SIR2 family of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2-fam; cd01407
656519007327	NAD+ binding site [chemical binding]; other site
656519007328	substrate binding site [chemical binding]; other site
656519007329	Zn binding site [ion binding]; other site
656519007330	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
656519007331	active site
656519007332	phosphorylation site [posttranslational modification]
656519007333	Lactadehyde:propanediol oxidoreductase (LPO) catalyzes the interconversion between L-lactaldehyde and L-1,2-propanediol in Escherichia coli and other enterobacteria; Region: LPO; cd08176
656519007334	Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454
656519007335	dimer interface [polypeptide binding]; other site
656519007336	active site
656519007337	metal binding site [ion binding]; metal-binding site
656519007338	Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239
656519007339	MgtE intracellular N domain; Region: MgtE_N; cl15244
656519007340	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE.  MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606
656519007341	Divalent cation transporter; Region: MgtE; cl00786
656519007342	Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367
656519007343	dimerization domain swap beta strand [polypeptide binding]; other site
656519007344	regulatory protein interface [polypeptide binding]; other site
656519007345	active site
656519007346	regulatory phosphorylation site [posttranslational modification]; other site
656519007347	lipoate-protein ligase A; Provisional; Region: lplA; PRK03822
656519007348	Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057
656519007349	Bacterial lipoate protein ligase C-terminus; Region: Lip_prot_lig_C; pfam10437
656519007350	PTS system glucitol/sorbitol-specific IIA component; Region: PTSIIA_gutA; cl01516
656519007351	Phosphotransferase system sorbitol-specific component IIBC [Carbohydrate transport and metabolism]; Region: SrlE; COG3732
656519007352	Sorbitol phosphotransferase enzyme II N-terminus; Region: EIIBC-GUT_N; pfam03612
656519007353	Sorbitol phosphotransferase enzyme II C-terminus; Region: EIIBC-GUT_C; pfam07663
656519007354	PTS system enzyme II sorbitol-specific factor; Region: EII-GUT; cl01515
656519007355	Glucitol operon activator protein (GutM); Region: GutM; cl01890
656519007356	Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390
656519007357	Helix-turn-helix domains; Region: HTH; cl00088
656519007358	Putative sugar-binding domain; Region: Sugar-bind; pfam04198
656519007359	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
656519007360	E3 interaction surface; other site
656519007361	lipoyl attachment site [posttranslational modification]; other site
656519007362	dihydrolipoamide acetyltransferase; Reviewed; Region: PRK11857
656519007363	e3 binding domain; Region: E3_binding; pfam02817
656519007364	2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; cl02008
656519007365	Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022
656519007366	Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036
656519007367	alpha subunit interface [polypeptide binding]; other site
656519007368	TPP binding site [chemical binding]; other site
656519007369	heterodimer interface [polypeptide binding]; other site
656519007370	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
656519007371	pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_y; TIGR03182
656519007372	Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000
656519007373	tetramer interface [polypeptide binding]; other site
656519007374	TPP-binding site [chemical binding]; other site
656519007375	heterodimer interface [polypeptide binding]; other site
656519007376	phosphorylation loop region [posttranslational modification]
656519007377	Predicted homoserine dehydrogenase [Amino acid transport and metabolism]; Region: COG4091
656519007378	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
656519007379	NAD(P) binding site [chemical binding]; other site
656519007380	SAF domain; Region: SAF; cl00555
656519007381	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459
656519007382	PAS domain S-box; Region: sensory_box; TIGR00229
656519007383	PAS fold; Region: PAS_4; pfam08448
656519007384	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
656519007385	PAS domain; Region: PAS_9; pfam13426
656519007386	putative active site [active]
656519007387	heme pocket [chemical binding]; other site
656519007388	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
656519007389	metal binding site [ion binding]; metal-binding site
656519007390	active site
656519007391	I-site; other site
656519007392	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
656519007393	Zn2+ binding site [ion binding]; other site
656519007394	Mg2+ binding site [ion binding]; other site
656519007395	Escherichia coli UshA-like family, N-terminal metallophosphatase domain; Region: MPP_UshA_N_like; cd00845
656519007396	active site
656519007397	metal binding site [ion binding]; metal-binding site
656519007398	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
656519007399	5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872
656519007400	TraB family; Region: TraB; cl12050
656519007401	dihydroxyacetone kinase subunit DhaK; Provisional; Region: PRK14481; cl10557
656519007402	Dihydroxyacetone kinase [Carbohydrate transport and metabolism]; Region: DAK1; COG2376
656519007403	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167
656519007404	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
656519007405	DNA-binding site [nucleotide binding]; DNA binding site
656519007406	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
656519007407	pyridoxal 5'-phosphate binding site [chemical binding]; other site
656519007408	homodimer interface [polypeptide binding]; other site
656519007409	catalytic residue [active]
656519007410	pyridoxal 5'-phosphate synthase, synthase subunit Pdx1; Region: TIGR00343
656519007411	PdxS is a subunit of the pyridoxal 5'-phosphate (PLP) synthase, an important enzyme in deoxyxylulose 5-phosphate (DXP)-independent pathway for de novo biosynthesis of PLP,  present in some eubacteria, in archaea, fungi, plants, plasmodia, and some...; Region: pdxS; cd04727
656519007412	active site
656519007413	multimer interface [polypeptide binding]; other site
656519007414	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
656519007415	S-adenosylmethionine binding site [chemical binding]; other site
656519007416	SNARE associated Golgi protein; Region: SNARE_assoc; cl00429
656519007417	Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586
656519007418	Cysteine-rich domain; Region: CCG; pfam02754
656519007419	Cysteine-rich domain; Region: CCG; pfam02754
656519007420	putative glutamate synthase (NADPH) small subunit; Provisional; Region: PRK12771
656519007421	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
656519007422	putative inner membrane protein; Provisional; Region: PRK11099
656519007423	Sulphur transport; Region: Sulf_transp; cl01018
656519007424	SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain.  SirA (also known as UvrY,  and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291
656519007425	CPxP  motif; other site
656519007426	Sulphur transport; Region: Sulf_transp; cl01018
656519007427	Sugar diacid utilization regulator [Transcription / Signal transduction mechanisms]; Region: CdaR; COG3835
656519007428	Helix-turn-helix domains; Region: HTH; cl00088
656519007429	Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897
656519007430	Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448
656519007431	active site residue [active]
656519007432	Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449
656519007433	active site residue [active]
656519007434	Winged helix-turn helix; Region: HTH_29; pfam13551
656519007435	Helix-turn-helix domains; Region: HTH; cl00088
656519007436	Integrase core domain; Region: rve; cl01316
656519007437	DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043
656519007438	Ferritin-like domain; Region: Ferritin; pfam00210
656519007439	dimerization interface [polypeptide binding]; other site
656519007440	DPS ferroxidase diiron center [ion binding]; other site
656519007441	ion pore; other site
656519007442	Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826
656519007443	Helix-turn-helix domains; Region: HTH; cl00088
656519007444	Integrase core domain; Region: rve; cl01316
656519007445	Helix-turn-helix domains; Region: HTH; cl00088
656519007446	HTH-like domain; Region: HTH_21; pfam13276
656519007447	Integrase core domain; Region: rve; cl01316
656519007448	Integrase core domain; Region: rve_3; cl15866
656519007449	Antidote-toxin recognition MazE; Region: Antitoxin-MazE; cl00877
656519007450	Helix-turn-helix domains; Region: HTH; cl00088
656519007451	putative transposase OrfB; Reviewed; Region: PHA02517
656519007452	HTH-like domain; Region: HTH_21; pfam13276
656519007453	Integrase core domain; Region: rve; cl01316
656519007454	Integrase core domain; Region: rve_3; cl15866
656519007455	Intracellular proteinase inhibitor; Region: BsuPI; pfam12690
656519007456	Uncharacterized protein family UPF0047; Region: UPF0047; cl00439
656519007457	MgtC family; Region: MgtC; pfam02308
656519007458	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
656519007459	metal binding site [ion binding]; metal-binding site
656519007460	active site
656519007461	I-site; other site
656519007462	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
656519007463	pyruvate:ferredoxin (flavodoxin) oxidoreductase, homodimeric; Region: pyruv_ox_red; TIGR02176
656519007464	Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034
656519007465	dimer interface [polypeptide binding]; other site
656519007466	PYR/PP interface [polypeptide binding]; other site
656519007467	TPP binding site [chemical binding]; other site
656519007468	substrate binding site [chemical binding]; other site
656519007469	Pyruvate ferredoxin/flavodoxin oxidoreductase; Region: POR; cl00546
656519007470	Domain of unknown function; Region: EKR; cl11037
656519007471	4Fe-4S binding domain; Region: Fer4; cl02805
656519007472	Thiamine pyrophosphate (TPP family), PFOR_PNO subfamily, TPP-binding module; composed of proteins similar to the single subunit pyruvate ferredoxin oxidoreductase (PFOR) of Desulfovibrio Africanus, present in bacteria and amitochondriate eukaryotes. This...; Region: TPP_PFOR_PNO; cd03377
656519007473	TPP-binding site [chemical binding]; other site
656519007474	dimer interface [polypeptide binding]; other site
656519007475	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
656519007476	UDP-glucose 6-dehydrogenase; Provisional; Region: PRK15057
656519007477	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
656519007478	UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984
656519007479	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
656519007480	Glutamate-cysteine ligase family 2(GCS2); Region: GCS2; cl00954
656519007481	Membrane protein of unknown function; Region: DUF360; cl00850
656519007482	Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031
656519007483	CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561
656519007484	dimer interface [polypeptide binding]; other site
656519007485	pyridoxal 5'-phosphate binding site [chemical binding]; other site
656519007486	catalytic residue [active]
656519007487	Serine acetyltransferase, N-terminal; Region: SATase_N; cl05762
656519007488	serine O-acetyltransferase; Region: cysE; TIGR01172
656519007489	Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354
656519007490	trimer interface [polypeptide binding]; other site
656519007491	active site
656519007492	substrate binding site [chemical binding]; other site
656519007493	CoA binding site [chemical binding]; other site
656519007494	phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885
656519007495	Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844
656519007496	ATP-grasp domain; Region: ATP-grasp_4; cl03087
656519007497	Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843
656519007498	Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108
656519007499	Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788
656519007500	GDP-binding site [chemical binding]; other site
656519007501	ACT binding site; other site
656519007502	IMP binding site; other site
656519007503	adenylosuccinate lyase; Provisional; Region: PRK07380
656519007504	Adenylsuccinate lyase (ASL)_subgroup 1; Region: Adenylsuccinate_lyase_1; cd01360
656519007505	tetramer interface [polypeptide binding]; other site
656519007506	active site
656519007507	DNA replication protein DnaC; Validated; Region: PRK06835
656519007508	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
656519007509	Walker A motif; other site
656519007510	ATP binding site [chemical binding]; other site
656519007511	Walker B motif; other site
656519007512	arginine finger; other site
656519007513	replicative DNA helicase; Region: DnaB; TIGR00665
656519007514	DnaB-like helicase N terminal domain; Region: DnaB; pfam00772
656519007515	DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the  chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984
656519007516	Walker A motif; other site
656519007517	ATP binding site [chemical binding]; other site
656519007518	Walker B motif; other site
656519007519	DNA binding loops [nucleotide binding]
656519007520	PspC domain; Region: PspC; cl00864
656519007521	Negative regulator of sigma E activity [Signal transduction mechanisms]; Region: RseB; COG3026
656519007522	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
656519007523	FtsX-like permease family; Region: FtsX; cl15850
656519007524	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
656519007525	FtsX-like permease family; Region: FtsX; cl15850
656519007526	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
656519007527	This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE).  They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255
656519007528	Walker A/P-loop; other site
656519007529	ATP binding site [chemical binding]; other site
656519007530	Q-loop/lid; other site
656519007531	ABC transporter signature motif; other site
656519007532	Walker B; other site
656519007533	D-loop; other site
656519007534	H-loop/switch region; other site
656519007535	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
656519007536	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
656519007537	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
656519007538	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; cl11611
656519007539	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
656519007540	Ligand Binding Site [chemical binding]; other site
656519007541	Transcriptional regulators [Transcription]; Region: PurR; COG1609
656519007542	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
656519007543	DNA binding site [nucleotide binding]
656519007544	domain linker motif; other site
656519007545	Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267
656519007546	ligand binding site [chemical binding]; other site
656519007547	dimerization interface [polypeptide binding]; other site
656519007548	Membrane transport protein; Region: Mem_trans; cl09117
656519007549	putative D-mannonate oxidoreductase, classical (c) SDR; Region: mannonate_red_SDR_c; cd08935
656519007550	putative NAD(P) binding site [chemical binding]; other site
656519007551	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557
656519007552	active site
656519007553	mannonate dehydratase; Provisional; Region: PRK03906
656519007554	mannonate dehydratase; Region: uxuA; TIGR00695
656519007555	50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137
656519007556	Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281
656519007557	Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948
656519007558	Predicted membrane protein (DUF2232); Region: DUF2232; cl01728
656519007559	Ribosomal protein S18; Region: Ribosomal_S18; cl00373
656519007560	SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496
656519007561	dimer interface [polypeptide binding]; other site
656519007562	ssDNA binding site [nucleotide binding]; other site
656519007563	tetramer (dimer of dimers) interface [polypeptide binding]; other site
656519007564	Ribosomal protein S6; Region: Ribosomal_S6; cl00414
656519007565	PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474
656519007566	active site
656519007567	GTP-binding protein YchF; Reviewed; Region: PRK09601
656519007568	YchF GTPase; Region: YchF; cd01900
656519007569	G1 box; other site
656519007570	GTP/Mg2+ binding site [chemical binding]; other site
656519007571	Switch I region; other site
656519007572	G2 box; other site
656519007573	Switch II region; other site
656519007574	G3 box; other site
656519007575	G4 box; other site
656519007576	G5 box; other site
656519007577	TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867
656519007578	Bacterial protein of unknown function (DUF951); Region: DUF951; cl01864
656519007579	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
656519007580	binding surface
656519007581	TPR motif; other site
656519007582	TPR repeat; Region: TPR_11; pfam13414
656519007583	Tetratricopeptide repeat; Region: TPR_16; pfam13432
656519007584	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
656519007585	Glycine cleavage system protein P (pyridoxal-binding), C-terminal domain [Amino acid transport and metabolism]; Region: GcvP; COG1003
656519007586	Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613
656519007587	tetramer interface [polypeptide binding]; other site
656519007588	pyridoxal 5'-phosphate binding site [chemical binding]; other site
656519007589	catalytic residue [active]
656519007590	Glycine cleavage system protein P (pyridoxal-binding), N-terminal domain [Amino acid transport and metabolism]; Region: GcvP; COG0403
656519007591	Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613
656519007592	pyridoxal 5'-phosphate binding site [chemical binding]; other site
656519007593	tetramer interface [polypeptide binding]; other site
656519007594	catalytic residue [active]
656519007595	Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848
656519007596	lipoyl attachment site [posttranslational modification]; other site
656519007597	glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389
656519007598	Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669
656519007599	Protein of unknown function (DUF554); Region: DUF554; cl00784
656519007600	ParB-like partition proteins; Region: parB_part; TIGR00180
656519007601	ParB-like nuclease domain; Region: ParBc; cl02129
656519007602	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
656519007603	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
656519007604	P-loop; other site
656519007605	Magnesium ion binding site [ion binding]; other site
656519007606	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
656519007607	Magnesium ion binding site [ion binding]; other site
656519007608	ParB-like partition proteins; Region: parB_part; TIGR00180
656519007609	ParB-like nuclease domain; Region: ParBc; cl02129
656519007610	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl15754
656519007611	tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192
656519007612	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
656519007613	GidA associated domain 3; Region: GIDA_assoc_3; pfam13932
656519007614	tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291
656519007615	GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396
656519007616	trmE is a tRNA modification GTPase; Region: trmE; cd04164
656519007617	G1 box; other site
656519007618	GTP/Mg2+ binding site [chemical binding]; other site
656519007619	Switch I region; other site
656519007620	G2 box; other site
656519007621	Switch II region; other site
656519007622	G3 box; other site
656519007623	G4 box; other site
656519007624	G5 box; other site
656519007625	Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631
656519007626	Predicted RNA-binding protein [General function prediction only]; Region: Jag; COG1847
656519007627	jag_K homology RNA-binding domain. The KH domain is found in proteins homologous to the Bacillus subtilis protein Jag, which is associated with SpoIIIJ and is necessary for the third stage of sporulation.  The KH motif is a beta-alpha-alpha-beta-beta...; Region: jag_KH; cd02414
656519007628	G-X-X-G motif; other site
656519007629	R3H domain found in proteins homologous to Bacillus subtilus Jag, which is associated with SpoIIIJ. SpoIIIJ is necessary for the third stage of sporulation. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine...; Region: R3H_jag; cd02644
656519007630	RxxxH motif; other site
656519007631	60Kd inner membrane protein; Region: 60KD_IMP; cl00489
656519007632	Haemolytic domain; Region: Haemolytic; cl00506
656519007633	Ribonuclease P; Region: Ribonuclease_P; cl00457